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Статті в журналах з теми "Bitter taster receptor"
Feeney, E., S. O'Brien, A. Scannell, A. Markey, and E. R. Gibney. "Genetic variation in taste perception: does it have a role in healthy eating?" Proceedings of the Nutrition Society 70, no. 1 (November 22, 2010): 135–43. http://dx.doi.org/10.1017/s0029665110003976.
Повний текст джерелаAbrol, Ravinder, Jun Tan, Hongxiang Hui, William A. Goddard III, and Stephen J. Pandol. "Structural basis for bitter taste receptor activation and its potential role in targeting diabetes." Functional Foods in Health and Disease 5, no. 3 (March 18, 2015): 117. http://dx.doi.org/10.31989/ffhd.v5i3.176.
Повний текст джерелаPilic, Leta, Catherine Anna-Marie Graham, Nisrin Hares, Megan Brown, Jonathan Kean, Yasmin Wehliye, Ella McGrigor, et al. "Bitter Taste Sensitivity Is Determined by TAS2R38 Haplotype, Associated with Saturated Fat Intake and Is Lower in Overweight and Obese Compared to Normal Weight UK adults." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 1271. http://dx.doi.org/10.1093/cdn/nzaa058_029.
Повний текст джерелаBiró, Barbara, Dániel Koren, Adrienn Lichthammer, Márta Veresné Bálint, Attila Gere, and Zoltán Kókai. "Relationships amongst phenyltiocarbamide sensitivity, body composition, coffee and tea consumption." Élelmiszervizsgálati Közlemények 68, no. 2 (2022): 3855–65. http://dx.doi.org/10.52091/evik-2022/2-1-eng.
Повний текст джерелаErgün, Can, and Meral Aksoy. "Relationships between the hTAS2R38 genotype, food choice, and anthropometric variables in normal-weighted and overweight adults." Genetika 45, no. 2 (2013): 381–91. http://dx.doi.org/10.2298/gensr1302381e.
Повний текст джерелаINOUE, MASASHI, XIA LI, STUART A. McCAUGHEY, GARY K. BEAUCHAMP, and ALEXANDER A. BACHMANOV. "Soa genotype selectively affects mouse gustatory neural responses to sucrose octaacetate." Physiological Genomics 5, no. 4 (April 27, 2001): 181–86. http://dx.doi.org/10.1152/physiolgenomics.2001.5.4.181.
Повний текст джерелаTaha, Mohamed A., Christian A. Hall, Colin J. Shortess, Richard F. Rathbone, and Henry P. Barham. "Treatment Protocol for COVID-19 Based on T2R Phenotype." Viruses 13, no. 3 (March 18, 2021): 503. http://dx.doi.org/10.3390/v13030503.
Повний текст джерелаDeshaware, Shweta, and Rekha Singhal. "Genetic variation in bitter taste receptor gene TAS2R38 , PROP taster status and their association with body mass index and food preferences in Indian population." Gene 627 (September 2017): 363–68. http://dx.doi.org/10.1016/j.gene.2017.06.047.
Повний текст джерелаLemon, Christian H., and David V. Smith. "Neural Representation of Bitter Taste in the Nucleus of the Solitary Tract." Journal of Neurophysiology 94, no. 6 (December 2005): 3719–29. http://dx.doi.org/10.1152/jn.00700.2005.
Повний текст джерелаSchiffman, SS. "Taste Transduction and Modulation." Physiology 3, no. 3 (June 1, 1988): 109–12. http://dx.doi.org/10.1152/physiologyonline.1988.3.3.109.
Повний текст джерелаДисертації з теми "Bitter taster receptor"
Clapp, Tod R. "Characterization of IP₃ receptors in bitter taste transduction." Access citation, abstract and download form; downloadable file 3.78 Mb, 2004. http://wwwlib.umi.com/dissertations/fullcit/3131664.
Повний текст джерелаJohnson, Claire. "Sensory and chemical analysis of the bitter-sweet taste interaction." Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262530.
Повний текст джерелаPydi, Sai Prasad. "Structural and functional characterization of bitter taste receptors, T2R1 and T2R4." American Society for Biochemistry and Molecular Biology, 2011. http://hdl.handle.net/1993/23607.
Повний текст джерелаBufe, Bernd. "Identifizierung und Charakterisierung von Bitterrezeptoren." Phd thesis, [S.l.] : [s.n.], 2003. http://pub.ub.uni-potsdam.de/2004/0013/bufe.pdf.
Повний текст джерелаBrissard, Léa. "Mechanisms of gustatory perception of dietary lipids : cross-talk with bitter taste and endocannabinoid receptors." Thesis, Bourgogne Franche-Comté, 2018. http://www.theses.fr/2018UBFCK071/document.
Повний текст джерелаObesity is one of the major public health problems at the beginning of the 21st century. Its prevalence is increasing steadily, especially among children. This observation is not insignificant because obesity is generally associated with various serious pathologies (type 2 diabetes, hypertension and cancer, etc.). Thus, investigations into the mechanisms involved in the taste perception of dietary lipids could shed light on their roles in the incidence of obesity.Several studies have demonstrated the role of endocannabinoids and bitter foods in obesity. Thus, we studied the cross-talk of cannabinoid receptors and bitter taste with lipid taste. This thesis has two components: cannabinoid receptors (CB1R), bitter taste and their interactions with lipid receptors.In the first part, we studied the regulatory role of CB1R. In the present study, behavioral tests on CB1R-/- mice and wild-type (WT) mice showed that the invalidation of the Cb1r gene was associated with a low preference for solutions containing rapeseed oil or a long chain fatty acid (LCFA) such as linoleic acid (LA). Administration of rimonabant, a CB1R inverse agonist, in mice also resulted in a low preference for dietary fatty acids. No differences in the expression of CD36 and GPR120 proteins were observed in the taste buds cells of the WT and CB1R-/- mice. Calcium signaling via CD36 in the taste bud cells of CB1R-/- mice decreased significantly compared with those observed in the taste cells of WT mice. The taste bud cells of CB1R-/- mice also show a significant decrease in Pro-glucagon and Glp-1r mRNA and a low basal level of GLP-1. We report that CB1R is involved in the perception of fat taste via calcium signaling and secretion of GLP-1.In the second part, we first characterized the phenotype of human fungiform cells (HTC-8). Indeed, the project of my thesis includes the characterization on the molecular scale of bitter and lipid receptors and their cross-talk in these cells (collaboration BRAIN, Germany). We have demonstrated that HTC-8 cells express PLCβ2 and α-gustducin at the mRNA and protein level. They also express TAS2R16 and TAS2R38 and these same cells co-express CD36 and GPR120. Then, we studied signaling via these receptors using linoleic acid, a CD36 and GPR120 agonist, sinigrin, TAS2R16 agonist and TAS2R38, salicin, TAS2R16 receptor agonist, and phenylthiocarbamide, TAS2R38 receptor agonist. In addition, calcium signal studies have shown that downstream fatty signaling shares a common path with downstream bitter taste signaling, highlighting a cross-talk between these two taste modalities.Although we have shown the cross-talk between bitter and lipid taste modalities, we still have to study these phenomena at the level of the organism. These results, already, show that the bitter taste and the cannabinoid-1 receptor are related to the taste sensitivity of fat and must be taken into account for the management of obesity
Grau, Bové Maria Carme. "Regulation of enteroendocrine function by bioactive components through their interaction with bitter taste receptors." Doctoral thesis, Universitat Rovira i Virgili, 2021. http://hdl.handle.net/10803/672967.
Повний текст джерелаEl sistema enteroendocrino se encuentra en el tracto gastrointestinal y controla el apetito y la actividad pancreática endocrina, entre otras funciones. Los compuestos bioactivos que estimulan este sistema son candidatos terapéuticos para tratar patologías relacionadas con estas funciones. Previamente se identificó que un extracto de proantocianidinas de semillas de uva (GSPE) es antidiabético por sus capacidades de mejora de la función de las células y su capacidad saciante, como consecuencia en parte activar del sistema enteroendocrino. Nuestro grupo relacionó las secreciones enteroendocrinas inducidas por polifenoles con la estimulación de receptores del gusto amargo (TAS2R) in vitro, pero si esto se refleja en una ingesta alterada aún se desconoce. Por esto, es necesario comprender mejor este sistema para poder desarrollar mejores estrategias terapéuticas. Esta tesis aborda si las secreciones enteroendocrinas inducidas por GSPE modulan la producción de glucagón pancreático y si estas se regulan mediante la estimulación específica de TAS2R que conduce a un control diferencial de la ingesta. Esta hipótesis se ha evaluado con estudios in vivo en ratas y estudios ex vivo en muestras intestinales. Hemos identificado que el glucagón es más sensible que la insulina a GSPE, lo que se correlaciona con una secreción ileal de GLP1 mejorada.
The enteroendocrine system is located in the gastrointestinal tract and controls appetite and endocrine pancreatic activity, among other functions. Thus, bioactive compounds that stimulate the enteroendocrine system are therapeutic candidates for treating pathologies related to these functions. Previous research has identified a grape-seed proanthocyanidin extract (GSPE) as antidiabetic for its -cell function enhancement abilities and its appetitesuppressing activity at least partly through activating the enteroendocrine system. Moreover, our group has linked the polyphenol-induced enteroendocrine secretions to the stimulation of some bitter taste receptors (TAS2R) in vitro, but whether it results in an altered food intake has not been studied yet. Since little is known of the mechanisms used by polyphenols to stimulate secretory mechanisms of the enteroendocrine system, there is a need to fully comprehend this system to specifically target it with a therapeutic strategy. For this reason, this thesis addressed whether GSPE-induced enterohormone secretions modulate pancreatic glucagon production, and whether these secretions are regulated through the specific stimulation of TAS2R leading to a differential control of food intake. This hypothesis was assessed with in vivo studies in rats and ex vivo studies in intestinal samples.
Larsen, James D. "Nicotinic Acetylcholine Receptor Dependent Effects of Nicotine on HEK293T and HBO Cells." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5701.
Повний текст джерелаGous, Andries Gustav Stefanus. "Perceptions and acceptance of grapefruit-like model beverages that vary in taste colour and aroma sensory properties : effects of sensitivity to bitter taste and TAS2R38 and TAS2R19 bitter receptor genes." Thesis, University of Pretoria, 2019. http://hdl.handle.net/2263/77821.
Повний текст джерелаThesis (PhD)--University of Pretoria, 2019.
Food Science
PhD
Unrestricted
Loßow, Kristina. "Erzeugung und Charakterisierung von Mausmodellen mit lichtsensitivem Geschmackssystem zur Aufklärung der neuronalen Geschmackskodierung." Phd thesis, Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2012/5805/.
Повний текст джерелаTaste impression is based on the interaction of taste, smell and touch. To evaluate the nutritious content of food mammals possess five distinct taste qualities: sweet, bitter, umami (taste of amino acids), sour and salty. For bitter, sweet, and umami compounds taste signaling is initiated by binding of tastants to G protein-coupled receptors. The interactions of taste stimuli, usually watersoluble chemicals, with their cognate receptors lead to the activation of the G protein gustducin, which, in turn, initiates a signal resulting in the activation of gustatory afferents. However, details of gustatory signal transmission and processing as well as neural coding are only incompletely understood. This is partly due to the property of some tastants to elicit several sensations simultaneously, unspecific effects caused by the temperature, viscosity, osmolarity, and pH of the solvents, as well as by mechanical stimulation of the tongue during stimulus application. The analysis of gustatory processing of taste information are mainly based on mouse models after stimulation with bitter taste stimuli. Even though it is known that the mouse genome codes for 35 bitter taste receptor genes only few of them had been analysed so far. For better understanding and interpretation of animal experiments 16 mouse bitter receptors had been analysed by Calcium Imaging experiments with HEK293T cells. The data reveal that mouse bitter taste receptors are more narrow tuned than human bitter taste receptors, proving that the ligand spectra of murine and human orthologous receptors are not complient. In order to avoid the disturbing effects of solvents and stimulus application on the analysis of gustatory information transfer and processing, I employ an optogenetical approach to address this problem. For this purpose I generated three strains of gene-targeted mice in which the coding regions of the genes for the umami receptor subunit Tas1r1, the sweet receptor subunit Tas1r2 or the bitter taste receptor Tas2r114 have been replaced by the coding sequences of different opsins (photoreceptors of visual transduction) that are sensitive to light of various wavelengths. In these animals I should be able to activate sweet, bitter, or umami signalling by light avoiding any solvent effects. In initial experiments of this project I demonstrated that the various visual opsins indeed functionally couple to taste signal transduction pathway in oocyte expression system, generating basic knowledge and foundation for the generation of the gene-targeted animals. The knockout-knockin strategies have been successfully realized in the case of all three mouse models, revealed by RT-PCR, in situ hybridization and immunohistochemical analysis of taste papillae. All data confirm that the particular taste receptors have been replaced by the different opsins in taste cells. Further analysis concerning the functional consequences of opsin knockin and taste receptor knockout are part of prospective work.
Ali, Agha Moutaz. "Physiologie des récepteurs gustatifs chez la mouche de vinaigre (Drosophila melanogaster)." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLA037/document.
Повний текст джерелаIn most animals including insects, ingestion is preceded by a close examination of the food, for example in order to detect the presence of potentially noxious chemicals. This detection involves specialized gustatory cells, which are generally described as sensitive to “bitter” tastes. Using electrophysiology and behavioral observations, we studied how a model insect, Drosophila melanogaster, can detect potentially toxic substances (described here as “bitter”) when mixed with sugar molecules, with their gustatory neurons. In a first part, we studied how L-canavanine is detected. Lcanavanine is a pseudo amino acid, which is confounded with L-arginine by the metabolism. Proteins which include Lcanavanine are non-functional and this compound is toxic for animals including insects. Using genetic constructions based on the UAS-Gal4 expression system, we showed that Lcanavanine is detected by gustatory cells expressing a receptor protein, GR66a, which is specific to most cells capable of detecting bitter substances. We also showed that, contrary to caffeine, the detection of L-canavanine requires functional Gαo proteins. Then, we studied some aspects of the detection of mixtures of sweet and bitter molecules. In a first approach, we contributed to establish that L-canavanine does not impact sugar detection, while other chemicals like strychnine completely inhibit sugar detection. By using the UAS-Gal4 system to ablate bitter-sensitive cells, we could demonstrate that such inhibition is a specific property of sugar- sensitive cells. These cells should have thus receptors for bitter substances which have not been identified yet. We also examined the reverse interaction, which is a possible role of sweet molecules to inhibit the detection of bitter substances. We examined the detection of denatonium, berberine, caffeine and umbelliferone in the presence of 12 different sugars, using behavioral and electrophysiology observations. By using genetic construction to ablate sugar-sensitive cells, we found that the sugar inhibitory action is not due to the presence of sugar-sensitive cells. It should be noted, however that in our experimental conditions, this inhibitory action is less efficient than the inhibition of bitter upon sugar detection. In a last part, we examined the modulation of gustatory perception by analogs of leucokinine, which is a neuropeptide involved in the diuresis of insects. We show that these analogs, when mixed with sugars in solution, can inhibit sugar detection by gustatory sensilla, both in Aedes aegypti mosquitoes and in Drosophila. The detection of bitter molecules by gustatory neurons in Drosophila thus involves two main coding channels: one is specific, and involves gustatory cells dedicated to the detection of bitter molecules; the second one, less specific, is affecting cells which are dedicated to the detection of sugar molecules. Gustatory coding is thus a more complex phenomenon than previously thought on the basis of examining responses to single molecules, thus urging to study the responses of gustatory receptors to more complex and natural mixtures
Частини книг з теми "Bitter taster receptor"
Martin, Louis T. P., and Denis J. Dupré. "Bitter Taste Receptors." In Encyclopedia of Signaling Molecules, 553–59. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101498.
Повний текст джерелаMartin, Louis T. P., and Denis J. Dupré. "Bitter Taste Receptors." In Encyclopedia of Signaling Molecules, 1–6. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101498-1.
Повний текст джерелаShichida, Yoshinori, Takahiro Yamashita, Hiroo Imai, and Takushi Kishida. "Bitter Taste Receptors of Primates." In SpringerBriefs in Biology, 23–34. Tokyo: Springer Japan, 2013. http://dx.doi.org/10.1007/978-4-431-54222-3_2.
Повний текст джерелаUpadhyaya, Jasbir, Nisha Singh, Raj Bhullar, and Prashen Chelikani. "Biochemistry of Human Bitter Taste Receptors." In Bitterness, 1–20. Hoboken, New Jersey: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781118590263.ch1.
Повний текст джерелаBehrens, Maik, and Wolfgang Meyerhof. "Oral and Extraoral Bitter Taste Receptors." In Results and Problems in Cell Differentiation, 87–99. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-14426-4_8.
Повний текст джерелаBufe, Bernd, Ellen Schöley-Pohl, Dietmar Krautwurst, Thomas Hofmann, and Wolfgang Meyerhof. "Identification of Human Bitter Taste Receptors." In ACS Symposium Series, 45–59. Washington, DC: American Chemical Society, 2003. http://dx.doi.org/10.1021/bk-2003-0867.ch003.
Повний текст джерелаDeshpande, Deepak A., and Stephen B. Liggett. "Regulation of Intracellular Calcium by Bitter Taste Receptors on Airway Smooth Muscle." In Calcium Signaling In Airway Smooth Muscle Cells, 409–21. Cham: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-01312-1_23.
Повний текст джерелаNaim, M., S. Nir, A. I. Spielman, A. C. Noble, I. Peri, S. Rodin, and M. Samuelov-Zubare. "Hypothesis of Receptor-Dependent and Receptor-Independent Mechanisms for Bitter and Sweet Taste Transduction: Implications for Slow Taste Onset and Lingering Aftertaste." In ACS Symposium Series, 2–17. Washington, DC: American Chemical Society, 2002. http://dx.doi.org/10.1021/bk-2002-0825.ch001.
Повний текст джерелаFontanesi, L., F. Bertolini, E. Scotti, G. Schiavo, P. Trevisi, M. Colombo, P. L. Martelli, R. Casadio, and P. Bosi. "Bitter taste receptor genes in pigs: SNP identification by using next- generation semiconductor sequencing." In Energy and protein metabolism and nutrition in sustainable animal production, 297–98. Wageningen: Wageningen Academic Publishers, 2013. http://dx.doi.org/10.3920/978-90-8686-781-3_101.
Повний текст джерелаShepherd, Gordon M. "Taste Modalities and Wine Tasting." In Neuroenology, 106–14. Columbia University Press, 2016. http://dx.doi.org/10.7312/columbia/9780231177009.003.0012.
Повний текст джерелаТези доповідей конференцій з теми "Bitter taster receptor"
Salvator, H., S. Grassin-Delyle, N. Mantov, C. Abrial, M. Brollo, C. Faisy, E. Naline, L. J. Couderc, and P. Devillier. "Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4540.
Повний текст джерелаDang, T., A. Lokubandara, N. N. V. Nguyen, P. C. Lai, V. T. Nguyen, and C. Crasto. "User as a bitter tastant: immersive experience within the binding region of a bitter taste receptor." In The 19th International Conference on Modeling & Applied Simulation. CAL-TEK srl, 2020. http://dx.doi.org/10.46354/i3m.2020.mas.019.
Повний текст джерелаKuek, L. E., and R. J. Lee. "Expression and Function of Bitter Taste Receptors in the Human Airways." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a7478.
Повний текст джерелаXu, Wei. "Expansion of a bitter taste receptor family in a polyphagous insect herbivore." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.108651.
Повний текст джерелаRobinett, Kathryn S., Wayne C. Wang, Molly M. Malone, Demar Pitter, and Stephen B. Liggett. "Agonist-Promoted Desensitization Of Bitter Taste Receptors Expressed On Airway Smooth Muscle." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3643.
Повний текст джерелаJames, Anna, Kameran Daham, Barbro Dahlén, Gunilla Hedlin, Juha Kere, Jon Konradsen, Björn Nordlund, et al. "Expression Of Bitter Taste Receptors On Peripheral Blood Leukocytes From Asthmatic Patients." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6752.
Повний текст джерелаPulkkinen, Ville, Jesper Safholm, Martijn Manson, Mikael Adner, and Sven-Erik K. Dahlen. "Further Characterization Of Bitter Taste Receptor Agonists As Bronchodilators In Guinea Pig Trachea." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6477.
Повний текст джерелаRobinett, Kathryn S., Leann L. Silhan, Deepak A. Deshpande та Stephen B. Liggett. "Bitter Taste Receptors And β2-Adrenergic Receptors Mediate Relaxation Of Airway Smooth Muscle In An Additive Manner". У American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6272.
Повний текст джерелаGopallawa, I., and R. J. Lee. "Defining the Molecular Mechanisms of Bitter Taste Receptor Activated Nitric Oxide Production in Airway Cells." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a1270.
Повний текст джерелаDahlén, Sven-Erik, Ville Pulkkinen, Jesper Säfholm, Martijn Manson, and Mikael Adner. "Bitter Taste Receptor Agonists As A Novel Class Of Bronchodilators In Guinea-Pig And Rat Airways." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6381.
Повний текст джерелаЗвіти організацій з теми "Bitter taster receptor"
Naim, Michael, Andrew Spielman, Shlomo Nir, and Ann Noble. Bitter Taste Transduction: Cellular Pathways, Inhibition and Implications for Human Acceptance of Agricultural Food Products. United States Department of Agriculture, February 2000. http://dx.doi.org/10.32747/2000.7695839.bard.
Повний текст джерела