Дисертації з теми "Biosensors devices"
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Tsai, Long-Fang. "Microfluidic Devices and Biosensors." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/5821.
Повний текст джерелаParra, Cabrera César Alejandro. "Microfluidic devices with integrated biosensors for biomedical applications." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/284758.
Повний текст джерелаEn años recientes, la comunidad de LOC ha enfocado todos sus esfuerzos en la investigación de nuevas aplicaciones para la biomedicina y biotecnología. Algunos países en vías de desarrollados no tienen tecnologías de diagnóstico adecuadas, además el suministro y almacenamiento de los reactivos es en muchos casos limitado, y en ocasiones cuentan con un acceso limitado al consumo de energía. Por otra parte, los países desarrollados se han encontrado con una población envejecida, y por lo tanto se ha generado la necesidad de contar con nuevas tecnologías para el diagnóstico de enfermedades las cuales sean accesibles y orientadas a una terapia más personalizada. Tanto la microfluídica como los LOC han permitido la integración de funciones de análisis complejas capaces de desarrollar herramientas de diagnostico más precisas, de bajo coste y confiables. Actualmente toda la atención se ha centrado en el diseño de aplicaciones para administración de fármacos 1, análisis celular 2 y diagnostico de enfermedades 3. La introducción de la microfluídica ha servido para mejorar el desarrollo de nuevos dispositivos point-of-care, pero todavía existen algunos problemas que han evitado la producción masiva de estos LOC. Las áreas en las que se pretende conseguir una mejora son la recolección de la muestra, mejora de la interfaz entre el chip y el usuario, tratamiento previo de la muestra, mejorar la estabilidad de los reactivos, trabajo con muestras complejas, detección múltiple de biomarcadores y simplificación del sistema de medida 4. Nuestros esfuerzos se han dedicado en desarrollar un sistema LOC con capacidad de detección electroquímica ajustable a cualquier biomarcador, dependiendo únicamente en la cantidad de muestra y los tiempos de análisis. Nuestros dispositivos microfluídicos cuentan con biosensores integrados de bajo coste con capacidad de auto-funcionalización. La funcionalización de los biosensores se realiza in-situ y selectivamente, antes de la detección, manteniendo el área de detección inerte hasta el inicio de la prueba. Los reactivos y el área de detección se almacenan por separado y entran en contacto hasta el inicio del experimento, lo cual facilita el método de fabricación. Se ha podido desarrollar este trabajo gracias a los estudios previos realizados en nuestro grupo en distintas disciplinas, tales como: microfluídica 5-8, funcionalización de superficies 9-14 y biosensores electroquímicos 15-19. Bibliografía 1. I. U. Khan, C. A. Serra, N. Anton and T. Vandamme, Journal of Controlled Release, 2013, 172, 1065-1074. 2. H. Andersson and A. Van den Berg, Sensors and Actuators B: Chemical, 2003, 92, 315-325. 3. M. J. Cima, Annual Review of Chemical and Biomolecular Engineering, 2011, 2, 355-378. 4. C. D. Chin, V. Linder and S. K. Sia, Lab on a Chip, 2012, 12, 2118-2134. 5. R. Rodriguez-Trujillo, C. A. Mills, J. Samitier and G. Gomila, Microfluidics and Nanofluidics, 2007, 3, 171-176. 6. R. Rodriguez-Trujillo, O. Castillo-Fernandez, M. Garrido, M. Arundell, A. Valencia and G. Gomila, Biosensors and Bioelectronics, 2008, 24, 290-296. 7. O. Castillo-Fernandez, R. Rodriguez-Trujillo, G. Gomila and J. Samitier, Microfluidics and Nanofluidics, 2014, 16, 91-99. 8. J. Comelles, V. Hortigüela, J. Samitier and E. Martínez, Langmuir, 2012, 28, 13688-13697. 9. E. Prats-Alfonso, F. García-Martín, N. Bayo, L. J. Cruz, M. Pla-Roca, J. Samitier, A. Errachid and F. Albericio, Tetrahedron, 2006, 62, 6876-6881. 10. J. Vidic, M. Pla-Roca, J. Grosclaude, M.-A. Persuy, R. Monnerie, D. Caballero, A. Errachid, Y. Hou, N. Jaffrezic-Renault, R. Salesse, E. Pajot-Augy and J. Samitier, Analytical Chemistry, 2007, 79, 3280-3290. 11. Y. Hou, S. Helali, A. Zhang, N. Jaffrezic-Renault, C. Martelet, J. Minic, T. Gorojankina, M.-A. Persuy, E. Pajot-Augy, R. Salesse, F. Bessueille, J. Samitier, A. Errachid, V. Akimov, L. Reggiani, C. Pennetta and E. Alfinito, Biosensors and Bioelectronics, 2006, 21, 1393-1402. 12. S. Rodríguez Seguí, M. Pla, J. Minic, E. Pajot‐Augy, R. Salesse, Y. Hou, N. Jaffrezic‐Renault, C. A. Mills, J. Samitier and A. Errachid, Analytical Letters, 2006, 39, 1735-1745. 13. A. Lagunas, J. Comelles, E. Martínez and J. Samitier, Langmuir, 2010, 26, 14154-14161. 14. A. Lagunas, J. Comelles, S. Oberhansl, V. Hortigüela, E. Martínez and J. Samitier, Nanomedicine: Nanotechnology, Biology and Medicine, 2013, 9, 694-701. 15. M. Castellarnau, N. Zine, J. Bausells, C. Madrid, A. Juárez, J. Samitier and A. Errachid, Materials Science and Engineering: C, 2008, 28, 680-685. 16. M. Castellarnau, N. Zine, J. Bausells, C. Madrid, A. Juárez, J. Samitier and A. Errachid, Sensors and Actuators B: Chemical, 2007, 120, 615-620. 17. M. Kuphal, C. A. Mills, H. Korri-Youssoufi and J. Samitier, Sensors and Actuators B: Chemical, 2012, 161, 279-284. 18. D. Caballero, E. Martinez, J. Bausells, A. Errachid and J. Samitier, Analytica Chimica Acta, 2012, 720, 43-48. 19. M. Barreiros dos Santos, J. P. Agusil, B. Prieto-Simón, C. Sporer, V. Teixeira and J. Samitier, Biosensors and Bioelectronics, 2013, 45, 174-180.
Olubi, Omotunde Eniola. "Electroactive polymeric materials for electronic devices and biosensors." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2014. http://digitalcommons.auctr.edu/dissertations/2262.
Повний текст джерелаWang, Ting. "Effect of surface conditions on DNA detection sensitivity by silicon based bio-sensing devices /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?ECED%202007%20WANGT.
Повний текст джерелаRuano-Lopez, Jesus M. "Optical devices for biochemical sensing in flame hydrolysis deposited glass." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368575.
Повний текст джерелаCastaing, Ambroise. "An investigation of epitaxial graphene growth and devices for biosensor applications." Thesis, Swansea University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678418.
Повний текст джерелаYoon, Sang Hoon Kim Dong Joo. "Growth and characterization of ZNO and PZT films for micromachined acoustic wave devices." Auburn, Ala, 2009. http://hdl.handle.net/10415/1719.
Повний текст джерелаPeláez, Gutiérrez Enelia Cristina. "Nanoplasmonic biosensors for clinical diagnosis, drug monitoring and therapeutic follow-up." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/672028.
Повний текст джерелаEsta Tesis Doctoral tiene como objetivo el desarrollo de diversos biosensores que operan sin necesidad de marcaje adicional basados en dispositivos plasmónicos ópticos para la detección directa de medicamentos o biomarcadores relacionados con diferentes enfermedades y que son analizados directamente en muestras humanas como plasma, suero, orina o esputo. Estos dispositivos biosensores ofrecen un sinnúmero de beneficios como es su alta sensibilidad, facilidad de operación, la obtención de datos cuantitativos, detección sin marcaje en tiempo real, y comúnmente sólo necesitan de un pequeño volumen de muestra. Todo esto convierte a los biosensores plasmónicos en herramientas analíticas muy adecuadas para el diagnóstico de enfermedades, el control de la medicación o el seguimiento de terapias personalizadas. Nuestro grupo de investigación ha demostrado exitosamente la implementación de biosensores ópticos basados en plasmónica y en fotónica de silicio, incluido el desarrollo completo de bioaplicaciones, lo que ha allanado el camino de su futura transferencia tecnológica para su implementación como dispositivos Point-of-Care (POC). Los biosensores desarrollados en esta Tesis incluyen su optimización y validación completa con muestras reales, ejemplificando algunos desafíos clínicos en los que dichos biosensores plasmónicos pueden superar importantes limitaciones de las técnicas de análisis convencionales actuales, mostrando su potencial y versatilidad como futuros dispositivos POC para ser usados en las unidades de atención primaria en salud o incluso en el entorno doméstico para el propio autocontrol por parte de los pacientes. La tesis está organizada en seis capítulos. El Capítulo 1 contiene la introducción de los conceptos básicos y el estado del arte sobre los avances actuales en las técnicas de diagnóstico y control de enfermedades y/o terapias y el papel que desempeñan los biosensores para mejorarlos. El Capítulo 2 incluye una descripción detallada de las plataformas biosensoras empleadas y una descripción general de los procesos metodológicos. El Capítulo 3 describe el desarrollo de un dispositivo nanoplasmónico para el control terapéutico del medicamento acenocumarol, un anticoagulante comúnmente administrado directamente en plasma humano. El Capítulo 4 se centra en el desarrollo de un biosensor plasmónico que sirva como control de la dieta libre de gluten que deben llevar los pacientes celíacos. El Capítulo 5 describe las estrategias desarrolladas para la detección de dos biomarcadores para el diagnóstico temprano de tuberculosis en muestras de esputo. Finalmente, el Capítulo 6 explora la detección de cuatro autoanticuerpos específicos asociados con la aparición del tumor directamente en el suero humano como biomarcadores potenciales para el diagnóstico temprano del cáncer colorrectal.
This Doctoral Thesis aims to the development of several label-free biosensing analytical strategies integrated within optical plasmonic devices for the direct detection of drugs or biomarkers related to different diseases in biological samples such as plasma, serum, urine, and sputum. These biosensor devices offer several benefits like their high sensitivity, ease of operation, quantitative data, label-free operation, and real-time detection, and commonly require a small sample volume. All this turn plasmonic biosensors into well-suited analytical tools for diagnosing diseases, monitoring medication, or for personalized therapies follow-up. Our research group has extensively demonstrated the successful conjunction of novel in-house optical biosensor configurations (like plasmonic and photonic-based designs) with the full demonstrations of bioapplications, which has paved the way for their potential technological transfer as Point-of-Care devices (POC) for clinical diagnostics. The biosensor assays here implemented, which include their full optimization and validation with real samples, exemplify clinical challenges where such biosensors can overcome limitations of current conventional analytical techniques. The results show the potential and versatility that plasmonic biosensors can offer as future POC devices placed in primary healthcare units or even in the household environment for patients’ self-monitoring. This thesis is organized into six chapters. Chapter 1 is the introductory one, which explains the basic concepts and the state of the art of the current advances in diagnosis and monitoring techniques of diseases and/or therapies and the role of biosensors to improve them. Chapter 2 includes a detailed description of the biosensor platforms employed and a general description of the methodological processes. Chapter 3 is related to the development of a nanoplasmonic device for the therapeutic monitoring of the drug acenocoumarol, a commonly administered anticoagulant, directly in human plasma. Chapter 4 focuses on the implementation of a plasmonic biosensor that monitors the gluten-free diet in urine in celiac patients. Chapter 5 describes the biosensing strategies developed for the detection of two biomarkers for the early diagnosis of tuberculosis in sputum samples. Finally, Chapter 6 explores the detection of four specific autoantibodies associated with the tumor onset directly in human serum as potential biomarkers for the early detection of colorectal cancer.
Universitat Autònoma de Barcelona. Programa de Doctorat en Química
McGovern, John-Paul Shih Wan Y. Shih Wei-Heng. "Flow-enhanced detection of biological pathogens using piezoelectric microcantilever arrays /." Philadelphia, Pa. : Drexel University, 2008. http://hdl.handle.net/1860/2910.
Повний текст джерелаdeSa, Johann Lec Ryszard. "Manipulation of microparticles using a piezoelectric actuator /." Philadelphia, Pa. : Drexel University, 2009. http://hdl.handle.net/1860/3197.
Повний текст джерелаGurazada, Saroja. "Use of yeast species as the biocomponent for priority environmental contaminants biosensor devices." Click here to access this resource online, 2008. http://hdl.handle.net/10292/430.
Повний текст джерелаHänisch, Jessica. "Synthesis, tailoring and passivation of Si nanowires towards hybrid devices." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19234.
Повний текст джерелаWithin this work, the “metal assisted chemical etching” (MACE) technique was combined with shadow nanosphere lithography to fabricate nanowire structured Si surfaces with different wire lengths and diameters. Electropolishing procedures subsequent to the wire growth resulted in a reduction of the surface defect density (DSS). The electropolishing procedure was directly monitored with the help of in situ photoluminescence spectroscopy. Previous works already observed a full and air stable surface passivation of flat Si surfaces by methylation. Also in the present work, the nanowire surfaces were methylated after the electropolishing procedure to preserve the reduced DSS. To determine the impact of this method on the solar cell performance, the electropolished and methylated surfaces were combined with the conductive polymer PEDOT:PSS. It revealed that the cells with the electropolished substrates exhibit a higher efficiency and an increased short circuit current (JSC). Different electrochemical procedures to change the wire morphology after the structuring have been investigated as well. To use the Si substrates for applications such as biosensing, different passivation/functionalization techniques besides the methylation are required. In this thesis, a new functionalization procedure was developed to obtain air stable hydroxyl groups that are directly bound to the Si substrate without an intervening oxide layer. To demonstrate the possibility to use these hydroxyl groups in the same way as the hydroxyl groups present on a Si oxide layer, further modifications with different silane species, such as APTES and AMMS, were conducted. In order to generate a more selective anchor group, the bound APTES molecules were further modified by a maleimide derivative, which allow for the selective binding of thiol-containing molecules.
Green, Eric C. Jean B. Randall. "Design of a microwave sensor for non-invasive determination of blood-glucose concentration." Waco, Tex. : Baylor University, 2005. http://hdl.handle.net/2104/3000.
Повний текст джерелаMcClung, Melanie J. Jean B. Randall. "Calibration methodology for a microwave non-invasive glucose sensor." Waco, Tex. : Baylor University, 2008. http://hdl.handle.net/2104/5164.
Повний текст джерелаYetisen, Ali Kemal. "Holographic point-of-care diagnostic devices." Thesis, University of Cambridge, 2014. https://www.repository.cam.ac.uk/handle/1810/246754.
Повний текст джерелаVenkatraman, Vishak. "Optical and Power Source Integrated Paper Microfluidic Devices for Point of Care Systems." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505206620429159.
Повний текст джерелаDerakhshani, Reza. "Determination of vitality from a non-invasive biomedical measurement for use in integrated biometric devices." Morgantown, W. Va. : [West Virginia University Libraries], 1999. http://etd.wvu.edu/templates/showETD.cfm?recnum=1035.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains x, 126 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. [72]-75).
Heitz, Benjamin Arthur. "Characterization of Novel Poly(lipid) BLMs for Long-Term Ion Channel Scaffolds Towards the Development of High-Throughput Screening Devices." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/196024.
Повний текст джерелаJoshi, Saumya [Verfasser], Paolo [Akademischer Betreuer] Lugli, Oliver [Gutachter] Hayden, and Paolo [Gutachter] Lugli. "Flexible biosensors using solution processable devices / Saumya Joshi ; Gutachter: Oliver Hayden, Paolo Lugli ; Betreuer: Paolo Lugli." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1201481619/34.
Повний текст джерелаGonzález, Flo Eva 1993. "Engineering living biomedical devices : Mathematical and experimental tools for the rational design of cellular devices." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2020. http://hdl.handle.net/10803/670358.
Повний текст джерелаL’aplicació de principis d’enginyeria en biologia permet somniar en l’ús de dispositius biològics per abordar problemes de la societat. Concretament, en aquesta tesi doctoral, s’ha abordat el disseny de dispositius biològics per aplicacions biomèdiques mitjançant la combinació d’eines experimentals i computacionals. La creació d’aquests dispositius demana d’un disseny racional que ofereixi respostes robustes i fiables. L’estudi de la creació de dispositius biològics s’ha fet seguint una aproximació modular, on s’ha analitzat com es poden re-enginyeritzar components cel·lulars per obtenir una resposta que s’adeqüi a l’aplicació requerida. Hem demostrat com podem modular el rang de detecció de la capa sensora a través de la modulació de l’element receptor de sensors bastats en dos components. Hem analitzat com integrar informació de diferents fonts de manera sistemàtica i robusta introduint com a nou element de computació l’espai i la divisió de tasques; tot desenvolupant un marc teòric i validant experimentalment per un seguit de funcions lògiques. Finalment, hem desenvolupat dispositius biològics que responen a molècules fisiològiques. Concretament, hem abordat el disseny de dispositius biològics pel tractament de la Diabetes Mellitus. Una primera validació experimental ens ha permès establir l’ús d’aquests dispositius in vitro. Seguidament, hem aprofundit en l’estudi de la seva aplicació mitjançant l’ús d’un simulador de pacient diabètic que ens ha permès el seu tractament virtual i l’anàlisi de les característiques del dispositiu per la regulació de la glicèmia. Finalment, hem explorat com la combinació dels dispositius cel·lulars amb la regulació del patró d’ingestes introdueix millores en els nivells de glucosa en sang. Posant de manifest el potencial que ofereix la creació d’una plataforma hibrida pel disseny de dispositius cel·lulars per una determinada aplicació.
Pappa, Anna maria. "Metabolite detection using organic electronic devices for point-of-care diagnostics." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEM020/document.
Повний текст джерелаRapid and early diagnosis of disease plays a major role in preventative healthcare. Undoubtedly, technological evolutions, particularly in microelectronics and materials science, have made the hitherto utopian scenario of portable, point-of-care personalized diagnostics a reality. Organic electronic materials, having already demonstrated a significant technological maturity with the development of high tech products such as displays for smartphones or portable solar cells, have emerged as especially promising candidates for biomedical applications. Their soft and fuzzy nature allows for an almost seamless interface with the biological milieu rendering these materials ideally capable of bridging the gap between electronics and biology. The aim of this thesis is to explore and validate the capabilities of organic electronic materials and devices in real-world biological sensing applications focusing on metabolite sensing, by combining both the right materials and device engineering. We show proof-of-concept studies including microfluidic integrated organic electronic platforms for multiple metabolite detection in bodily fluids, as well as more complex organic transistor circuits for detection in tumor cell cultures. We finally show the versatility of organic electronic materials and devices by demonstrating other sensing strategies such as nucleic acid detection using a simple biofunctionalization approach. Although the focus is on in vitro metabolite monitoring, the findings generated throughout this work can be extended to a variety of other sensing strategies as well as to applications including on body (wearable) or even in vivo sensing
García, Castelló Javier. "A Novel Approach to Label-Free Biosensors Based on Photonic Bandgap Structures." Doctoral thesis, Universitat Politècnica de València, 2014. http://hdl.handle.net/10251/35398.
Повний текст джерелаGarcía Castelló, J. (2014). A Novel Approach to Label-Free Biosensors Based on Photonic Bandgap Structures [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/35398
TESIS
Corso, Christopher David. "Theoretical and experimental development of a ZnO-based laterally excited thickness shear mode acoustic wave immunosensor for cancer biomarker detection." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24728.
Повний текст джерелаCommittee Chair: William D Hunt; Committee Member: Bruno Frazier; Committee Member: Dale Edmondson; Committee Member: Marie Csete; Committee Member: Peter Edmonson; Committee Member: Ruth O'Regan
Madiyar, Foram Ranjeet. "Nanoelectrode based devices for rapid pathogen detection and identification." Diss., Kansas State University, 2015. http://hdl.handle.net/2097/19782.
Повний текст джерелаDepartment of Chemistry
Jun Li
Developing new and rapid methods for pathogen detection with enhanced sensitivity and temporal resolution is critical for protecting general public health and implementing the food and water safety standards. In this research vertically aligned carbon nanofiber nanoelectrode arrays (VACNF NEAs) have been explored as a sample manipulation tool and coupled with fluorescence, surface enhanced Raman scattering (SERS) and impedance techniques for pathogen detection and identification. The key objective for employing a nanoelectrode array is that the nano-Dielectrophoresis (nano-DEP) at the tip of a carbon nanofiber (CNF) acts as a potential trap to capture pathogens. A microfluidic device was fabricated where nanofibers (~ 100 nm in diameter) were placed at the bottom of a fluidic channel to serve as a ‘point array’ while an indium tin oxide coated glass slide acted as a macroscale counter electrode. The electric field gradient was highly enhanced at the tips of the CNFs when an AC voltage was applied. The first study focused on the capture of the viral particles (Bacteriophage T4r) by employing a frequency of 10.0 kHz, a flow velocity of 0.73 mm/sec, and a voltage of 10.0 Vpp. A Lithenburg type of phenomenon was observed, that were drastically different from the isolated spots of bacteria captured on VACNF tips in previous study. At the lowest employed virus concentration (1 × 10[superscript]4 pfu/mL), a capture efficiency of 60% was observed with a fluorescence microscope. The motivation of the second study was to incorporate the SERS detection for specific pathogen identification. Gold-coated iron-oxide nanoovals labeled with Raman Tags (QSY 21), and antibodies that specifically bound with E.coli cells were utilized. The optimum capture was observed at a frequency of 100.0 kHz, a flow velocity of 0.40 mm/sec, and a voltage of 10.0 Vpp. The detection limit was ~210 CFU/mL for a portable Raman system with a capture time of 50 seconds. In the final study, a real-time impedance method was employed to detect Vaccinia virus (human virus) in the nano-DEP device at 1.0 kHz and 8.0 Vpp giving a detection limit of 2.51 × 10[superscript]3 pfu/mL.
Pasha, Syed Khalid. "Thin Film Based Biosensors for Point of Care Diagnosis of Cortisol." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3892.
Повний текст джерелаChamanzar, Maysamreza. "Hybrid nanoplasmonic-nanophotonic devices for on-chip biochemical sensing and spectroscopy." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/50145.
Повний текст джерелаGao, Puxian. "Piezoelectric Nanostructures of Zinc Oxide: Synthesis, Characterization and Devices." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/7564.
Повний текст джерелаSanders, Jeff T. "Spin polarization measurements and sensor applications in thin films and carbon nanotube-based devices." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001711.
Повний текст джерелаVadde, Venkatesh. "Phase Sensitive Estimation Of Fluorescence Lifetime For Fiber Optic Biosensors." Thesis, Indian Institute of Science, 1995. http://hdl.handle.net/2005/150.
Повний текст джерелаCastillo, Fernández Óscar. "Analysis and characterisation of biological samples in nano and microfluidic devices using AC and DC electric fields." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/97158.
Повний текст джерелаEsta tesis titulada “Analysis and characterisation of biological samples in nano and microfluidic devices using AC and DC electric fields” tiene como objetivo el estudiar los efectos que tienen los campos eléctricos sobre muestras biológicas con el fin de desarrollar herramientas microfluídicas (lab-on-a-chip) para la manipulación y detección de las muestras biológicas. El trabajo está dividido en tres ámbitos orientados a desarrollar dispositivos o módulos en un dispositivo para diagnóstico. En el primer bloque estudiamos el movimiento de moléculas de ADN (-DNA) en el interior de nanocanales de 20 nm de alto bajo la influencia de campos DC y AC. El objetivo es determinar el mecanismo que hay detrás de la separación por tamaño de esta molécula en ausencia de geles y matrices. En el segundo bloque desarrollamos un nuevo sistema dielectroforético de separación celular por tamaño, basado en la competencia entre la fuerza dielectroforética y las fuerzas fluídicas de arrastre. El sistema se utiliza para separar glóbulos rojos de monocitos en condiciones fisiológicas (alta conductividad) y en flujo continuo. En el tercer bloque desarrollamos una instrumentación para un microcitómetro de flujo basado en medidas de impedancia. El sistema electrónico se valida mediante la utilización de un sistema de óptico sincronizado que nos permite relacionar la señal obtenida con el paso de las células sobre el área de detección. Mediante este sistema se ponen aprueba las capacidades de detección, así como la capacidad de distinguir células por tamaño. Finalmente utilizamos el efecto de la focalización hidrodinámica para mejorar las prestaciones de sensibilidad de un sistema de electrodos coplanares.
Murdock, Richard C. "Development of Microfluidic Paper-based Analytical Devices for Point-of-Care Human Physiological and Performance Monitoring." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439308025.
Повний текст джерелаWathen, Adam Daniel. "Acoustic wave biosensor arrays for the simultaneous detection of multiple cancer biomarkers." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42717.
Повний текст джерелаVeliev, Farida. "Interfacing neurons with nanoelectronics : from silicon nanowires to carbon devices." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAI001/document.
Повний текст джерелаIn line with the technological progress of last decades a variety of adapted bioelectrical interfaces was developed to record electrical activity from the nervous system reaching from whole brain activity to single neuron signaling. Although neural interfaces have reached clinical utility and are commonly used in fundamental neuroscience, their performance is still limited. In this work we investigated alternative materials and techniques, which could improve the monitoring of neuronal activity of cultured networks, and the long-term performance of prospective neuroprosthetics. While silicon nanowire transistor arrays and diamond based microelectrodes are proposed for improving the spatial resolution and the electrode stability in biological environment respectively, the main focus of this thesis is set on the evaluation of graphene based field effect transistor arrays for bioelectronics. Due to its outstanding electrical, mechanical and chemical properties graphene appears as a promising candidate for the realization of chemically stable flexible electronics required for long-term neural interfacing. Here we demonstrate the outstanding neural affinity of pristine graphene and the realization of highly sensitive fast graphene transistors for neural interfaces
Bihar, Eloïse. "Réalisation de dispositifs biomédicaux par impression jet d’encre." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSEM036/document.
Повний текст джерелаWith the evolution of microelectronics industry and their direct implementation in the biomedical arena, innovative tools and technologies have come to the fore enabling more reliable and cost-effective treatment. In this thesis I focus on the integration of the conducting polymer PEDOT:PSS with printing technologies toward the realization of performant biomedical devices. In the first part, I focus on the optimization of the conducting ink formulation. Following, I emphasize on the fabrication of inkjet printed PEDOT:PSS based biopotential electrodes on a wide variety of substrates (i.e., paper, textiles, tattoo paper) for use in electrophysiological applications such as electrocardiography (ECG) and electromyography (EMG). Printed electrodes on paper and printed wearable electrodes were fabricated and investigated for long-term ECG recordings. Then, conformable printed tattoo electrodes were fabricated to detect the biceps activity during muscle contraction and the conventional wiring was replaced by a simple contact between the tattoo and a similarly ink-jet printed textile electrode.In the last part, I present the potentiality of inkjet printing method for the realization of organic electrochemical transistor (OECTs) as high performing biomedical devices. A disposable breathalyzer comprised of a printed OECT and modified with alcohol dehydrogenase was used for the direct alcohol detection in breath, enabling future integration with wearable devices for real-time health monitoring. Their compatibility with printing technologies allows the realization of low-cost and large area electronic devices, toward next-generation fully integrated smart biomedical devices
Ben, Aissa Soler Alejandra. "Rapid diagnostic test for the detection of communicable diseases." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2020. http://hdl.handle.net/10803/670392.
Повний текст джерелаLa prevención y el control de las enfermedades transmisibles dependen, en gran medida, de la detección rápida y eficaz. Los métodos convencionales para la detección de un patógeno, como el cultivo microbiológico, generalmente requieren mucho tiempo, son laboriosos, necesitan personal cualificado y no son aptos como herramientas de diagnóstico en el punto de atención. El desarrollo de métodos de diagnóstico rápido en el marco de los criterios ASSURED, del inglés (A) Affordable, (SS) Sensitive and Specific, (U) User-friendly, (R) Rapid and Robust, (E) Equipment free, and (D) Deliverable to those who need it, Affordable, descritos por la Organización Mundial de la Salud (OMS), se encuentran en la actualidad bajo intenso estudio. Por lo tanto, la presente tesis aborda el diseño y desarrollo de estrategias, métodos y materiales para mejorar las prestaciones analíticas y simplificar el procedimiento en pruebas de diagnóstico rápido, incluidas nuevas estrategias de preconcentración en fase sólida, métodos de amplificación y materiales avanzados, así como su integración en diferentes plataformas (principalmente biosensores basados en detección electroquímica y pruebas en papel con lectura óptica). En todos los casos, las aplicaciones seleccionadas se centran en enfermedades transmisibles, incluidos los patógenos transmitidas por los alimentos y las micobacterias. Con este fin, se comparan dos plataformas basadas en papel en diferentes configuraciones (flujo lateral y vertical) en términos del rendimiento analítico para la detección de Mycobacterium. Para lograr una mejora adicional en el límite de detección, se estudia la preconcentración previa de las bacterias por separación inmunomagnética. En segundo lugar, se evalúan y se comparan en términos de su rendimiento analítico la detección simultánea de Salmonella y E. coli mediante flujo lateral de ácido nucleico con lectura visual y genosensores electroquímicos. Si bien estos métodos requieren PCR de doble etiquetado para la amplificación, se pueden adaptar fácilmente a termocicladores portátiles que funcionan con baterías para poder ser realizados en entornos con recursos limitados para satisfacer las demandas de diagnóstico ASSURED. Además, también se presenta en esta disertación la síntesis de polímeros magnéticos impresos molecularmente, con el objeto de reemplazar las partículas magnéticas biológicamente modificadas, y tomando como modelo la detección de biotina y moléculas biotiniladas. Además, se realiza la caracterización del material mediante diferentes técnicas analíticas y se compara, en todos los casos, con el polímero no impreso. Este material biomimético muestra un gran potencial para la preconcentración y detección de una amplia gama de analitos. A pesar de todo este progreso, las técnicas de amplificación de ácido nucleico siguen siendo necesarias para alcanzar los límites de detección requeridos en algunas enfermedades transmisibles. Las técnicas de amplificación isotérmica son buenos candidatos para llevar pruebas de diagnóstico en entornos donde la PCR puede ser una barrera. En concreto, se describe en esta disertación la detección de E. coli mediante un genosensor electroquímico basada en la amplificación isotérmica. En este caso, se optimiza la lectura electroquímica por voltamperometría de onda cuadrada en electrodos desechables comparando dos estrategias de marcaje del producto amplificado. Es importante resaltar que todas estas estrategias apuntan a ser utilizadas como herramientas para mejorar las pruebas de diagnóstico rápido en entornos de bajos recursos, para interrumpir la cadena de infección de enfermedades transmisibles y permitir, por tanto, un tratamiento precoz.
The prevention and control of communicable disease rely, to a large extent, on effective and early detection approaches. Conventional methods for the detection of a pathogen, such as microbiological culture, are usually time-consuming, laborious, need skilled personnel and are non-amenable to point-of-care diagnostic tools. The development of rapid diagnostic methods in the framework of the ASSURED criteria as (A) Affordable, (SS) Sensitive and Specific, (U) User-friendly, (R) Rapid and Robust, (E) Equipment free, and (D) Deliverable to those who need it, outlined by the World Health Organization (WHO), are under intensive study. Therefore, the present dissertation addresses the design and development of strategies, methods and materials to improve the analytical performance and to simplify the analytical procedure in rapid diagnostic tests, including novel solid-phase preconcentration strategies, amplification methods and advanced materials, as well as their integration in different platforms (mainly biosensors based on electrochemical detection and paper-based strips for optical readout). In all instances, the applications selected are focused on communicable diseases, including foodborne pathogens and mycobacteria. Therefore, two paper-based platforms in different configurations (nucleic acid lateral and vertical flow) are compared in terms of the analytical performance for the detection of Mycobacterium. In order to achieve a further improvement in the limit of detection, the preconcentration of the bacteria is performed by immunomagnetic separation. Secondly, the simultaneous detection of Salmonella and E. coli by nucleic acid lateral flow with visual readout and electrochemical genosensing are evaluated and compared in terms of their analytical performance. Although these methods required double-tagging PCR for amplification, portable, battery-powered thermocyclers can easily be adapted for resource-constrained settings to meet the demands for ASSURED diagnosis. Furthermore, the synthesis of Magnetic Molecularly Imprinted Polymers, in order to replace biological-modified magnetic particles is also presented in this dissertation, taking as a model the detection of biotin and biotinylated molecules with outstanding performance. Moreover, the characterization of the material is performed by different analytical techniques and compared, in all instances, with the non-imprinted polymer. This biomimetic material shows a great potential for the preconcentration and detection of a huge range of analytes. Despite all these progress, nucleic acid amplification techniques are still necessary to reach the challenging limits of detection required in some communicable disease. Isothermal amplification techniques are good candidates to bring sensitive diagnostic tests in places where the PCR can be a barrier. In detail, the electrochemical genosensing of E. coli based on isothermal amplification is also described in this dissertation. In this approach, the electrochemical readout by square-wave voltammetry on disposable electrodes is optimized comparing two different labelling approaches. It is important to highlight that all these strategies aim to be used as tools for the improvement of rapid diagnostic test in low resource settings, to interrupt the chain of infection of communicable diseases and enabling the rapid treatment.
Bernat, Ubiaga Ivan. "Development of a Complete Optical Microsystem for Particle Flow Detection." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/133079.
Повний текст джерелаThis thesis summarizes the work developed in the Department of Electronics, Faculty of Physics, at the University of Barcelona. This work is focused on the design and fabrication of an optical microsystem based on hybrid integration of commercial components and silicon micromachining processes, in order to the optical detection of microparticles in microfluidic chips. Main goals are the miniaturization and integration of all components to obtain a robust system, portable, and oriented to "Point of care" applications. The optical detection system includes two commercial components. First, the chosen light sources, VCSEL lasers in "die " format from ULM Photonics, and second, an array of microlenses manufactured by SUSS microoptics. The microlens array fits the existing pitch between lasers (250 microns), therefore it is fully compatible in terms of optical alignment. To determine the optimal positions of these components, two scenarios are analyzed by using a ray tracing simulator (ZEMAX Radiance ®): the first, based on collimated light beams, the second based on obtaining focused light beams. The commercial components are assembled in a robust structure, consisting of two pieces of silicon (base and optical spacer), and passive alignment of the microlenses. The pieces of silicon are fabricated in wafers at the clean room of the IBM-CNM, according to the defined processes. Using soft lithography techniques, various chips for the microfluidic block are designed and fabricated: passive focusing channels and channels with hydrodynamic focusing. These chips contain microfluidic channels where particles to be detected will flow in liquid suspension. The optical detection system requires an optical sensor to detect the variations in the levels of light intensity caused by the particles circulation. In this thesis, an image sensor based on CMOS technology and a full-custom design is presented. The sensor includes a double linear array structure with 256 pixels and other electronics. To validate the functionality of the proposed system, we performed a battery of tests. Several aqueous suspensions were prepared in deionized water and isopropanol with particles of different sizes (diameters) materials and manufacturers in the range of 10 to 90micras diameter. The results were satisfactory in all cases.
Wingqvist, Gunilla. "Thin Film Electroacoustic Devices for Biosensor Applications." Doctoral thesis, Uppsala universitet, Fasta tillståndets elektronik, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89424.
Повний текст джерелаwisenet
Zhang, Han. "Micro-Biosensor Devices for Biochemical Analysis Applications." DigitalCommons@USU, 2020. https://digitalcommons.usu.edu/etd/7712.
Повний текст джерелаHan, Shu-Jen. "CMOS integrated biosensor array based on spin valve devices /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Повний текст джерелаXiao, Yuan, Yi Lu, Michael Hsieh, Joseph Liao, and Pak Kin Wong. "A Microfiltration Device for Urogenital Schistosomiasis Diagnostics." Public Library of Science, 2016. http://hdl.handle.net/10150/614655.
Повний текст джерелаCAMARA, ALEXANDRE DE RESENDE. "BIOSENSOR AND ELECTROOPTICAL DEVICE WITH SPECIAL FIBER OPTICS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2015. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=29585@1.
Повний текст джерелаCOORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
O presente trabalho investiga a utilização de fibras ópticas em biossensoriamento e na indução de uma não-linearidade de segunda ordem para a construção de dispositivos sensores. O biossensor proposto tem por finalidade diagnosticar uma das doenças com maior incidência em países tropicais: a Dengue. Foi construído um sensor a fibra óptica que potencialmente é capaz de diagnosticar, num tempo curto, a presença do vírus da Dengue no sangue de um paciente infectado. Esse sensor usa nanopartículas de ouro, depositadas na extremidade de uma fibra óptica, que foram funcionalizadas com os anticorpos da Dengue (anti-NS1). O sensor é capaz de detectar o antígeno NS1 em diferentes concentrações com um limite de quantificação de 0.074 micrograma por mililitro, podendo ser explorado para uso na fase aguda da infecção.Outra vertente do trabalho é a possibilidade de se realizar modificações estruturais nas fibras ópticas com o intuito de alterar as propriedades ópticas da fibra. Através da técnica de polarização térmica, é possível gravar campos elétricos da ordem de 108 volts por metro no núcleo da fibra óptica, sendo possível utilizar as fibras polarizadas como moduladores de fase e de amplitude, seletores de pulso, chaves ópticas, voltímetros, entre outras. O trabalho de tese aqui descrito apresenta um estudo detalhado da polarização térmica em fibras ópticas através de simulações, utilizando o software COMSOL Multiphysics, considerando-se os diversos parâmetros envolvidos e geometrias diferentes de fibras, visando a obtenção de uma alta não-linearidade de segunda ordem. Além do mais, experimentos foram realizados a fim de se entender o mecanismo presente no processo de polarização térmica face aos resultados obtidos pela simulação. Buscou-se, também, entender o papel dos portadores de cargas presentes no material no processo de geração de não-linearidade de segunda ordem realizando-se experimentos de polarização óptica.
The present work investigates the use of fiber optics in biosensing and the creation of a second order nonlinearity to be use in the development of sensor devices. The goal of the proposed biosensor is to diagnose one of the diseases with highest incidence in tropical countries: Dengue. Dengue is a dangerous disease that every year affects more and more people, despite the efforts made to deal with the transmitter, the mosquito Aedes aegypti. Furthermore, since Dengue symptoms resemble flu symptoms, wrong diagnoses are frequently made. As a consequence, wrong medicines may be prescribed, and that may lead the patient to death. Another problem in diagnosing Dengue is the long time is necessary for the laboratorial exams to give a result. In an attempt to offer a solution that could minimize these problems, an LSPR-based fiber optic sensor was adapted for antigen NS1 detection. This sensor is potentially able to perform a Dengue s virus diagnosis in a short period of time in an infected patient s blood. It uses gold nanoparticles that are functionalized with Dengue s antibodies. The antibody, anti-NS1, was immobilized in gold nanoparticles deposited at the endface of a multimode optical fiber. The LSPR sensor is able to detect different concentrations of the antigen NS1 with a limit of quantification equal to 0.074 microgram per milliliter, and may be used in the acute phase of the infection. Another part of the present work investigates the possibility of performing structural modifications in the optical fiber to change the optical properties of silica. Through the electro-thermal poling technique it is possible to record electric fields as high as 108 volts per meter in the core of the fiber, making possible the use of these modified fibers as phase and amplitude modulators, optical keys, pulse selectors, voltmeters, etc. This work also shows a very detailed study of electro-thermal poling in optical fiber through simulations, using the software Comsol Multiphysics, considering various parameters that are involved in the process in order to obtain high second order nonlinearity. Furthermore, experiments on eletro-optical poling were performed to investigate the mechanism involved in this poling process, in order to understand the role of the carriers present in the material in the generation of the second order nonlinearity.
Chen, Si. "Electronic Sensors Based on Nanostructured Field-Effect Devices." Doctoral thesis, Uppsala universitet, Fasta tillståndets elektronik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-194015.
Повний текст джерелаBonhomme, Jérémy. "Structures phononiques à ondes de Love pour la biodétection." Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0163.
Повний текст джерелаThe development of diodetection systems is extremely important for a large number of fields and the need to improve the sensitivity and precision of measurements is becoming an important issue for some advanced applications. Surface acoustic waves (SAW) are widely used for sensor applications, particularly for biodetection, however the theoretical limits of their sensitivity will soon be reached. At the same time, new methods of manipulating acoustic waves through periodic arrangements, called phononic crystals, have been developed. The objective is to show a proof of concept of the interaction of phononic structures coupled to a SAW Love waves device as well as their sensitivity to mass deposition in order to show their potential for biodetection applications. The work consisted of a numerical modeling step in order to design and optimize a reference phononic structure, then in an experimental phase with the development of cleanroom manufacturing processes and tests to characterize the devices and estimate a first sensitivity for this type of system
Heo, Jinseok. "Characterization and applications of microfluidic devices based on immobilized biomaterials." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4688.
Повний текст джерелаRamirez, Priego Patricia. "Low-cost point-of-care biosensor device for clinical diagnosis in developing countries." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/671902.
Повний текст джерелаActualmente el diagnóstico de Tuberculosis (TB) se realiza en laboratorios centralizados, empleando equipos voluminosos, reactivos complejos y personal capacitado, aumentando los costes y el tiempo para obtener los resultados. Por esta razón, el objetivo de esta Tesis Doctoral es el desarrollo de una plataforma point-of-care (POC) capaz de ofrecer una respuesta rápida y fiable en el diagnóstico de TB. Para llevar a cabo este objetivo, la plataforma POC integra un novedoso sensor fotónico incorporado en un cartucho de micofluídica desechable. El sensor fotónico consiste en un conjunto de interferómetros Mach-Zehnder que ofrecen una alta sensibilidad. En primer lugar, se llevó a cabo una caracterización óptica para estudiar el rendimiento de la plataforma POC y su capacidad para ser empleada en aplicaciones biosensoras. Una vez caracterizada ópticamente, se evaluaron distintas estrategias de biofuncionalización para incorporar anticuerpos específicos como bioreceptores a la superficie del sensor. Después de un estudio en profundidad, se seleccionó y empleó la estrategia de biofuncionalización óptima para el análisis de los biomarcadores de TB. Los biomarcadores de TB se evaluaron tanto en solución tampón como en muestras biológicas, particularmente en orina humana. El biomarcador más prometedor y conocido de TB es el lipoarabinomanano (LAM), un componente de la pared celular bacteriana. En concreto, la detección de este biomarcador fue validada con muestras clínicas de pacientes con TB y donantes sanos, mostrando la capacidad de nuestra plataforma POC para discriminar a aquellos pacientes con Tuberculosis activa. Además, el diseño del sensor fotónico permite la detección simultánea de seis biomarcadores distintos. Teniendo esto en cuenta, hemos llevado a cabo una prueba de concepto del empleo de la plataforma biosensora POC para la detección de un panel de biomarcadores de TB utilizando nanolitografía Dip-Pen para la deposición de cada bioreceptor en cada sensor. Nuestros resultados, validados en estudios clínicos más amplios, podrían tener importantes implicaciones diagnósticas. Además, nuestro biosensor POC ofrece una serie de ventajas en comparación con los métodos recomendados por la Organización Mundial de la Salud.
Nowadays, Tuberculosis (TB) diagnosis is carried out at centralised laboratories, employing bulky equipment, complex reagents, and trained staff, increasing costs and the time to obtain the results. For that reason, the aim of this Doctoral Thesis is to develop a point-of-care (POC) platform able to deliver a prompt and reliable response to TB diagnosis, taking advantage of a highly sensitive evanescent wave optical sensor. The POC platform integrates a novel photonic sensor consisting of a Mach-Zehnder Interferometer transducer array incorporated in a disposable microfluidic cartridge. Firstly, an optical characterisation was carried out to study the new POC performance and its ability to be employed for biosensing applications. Once the POC platform was optically characterised, diverse biofunctionalisation strategies were tested in order to incorporate specific antibodies as bioreceptors to the sensor surface. After an in-depth study, the optimal biofunctionalisation strategy was selected and employed for the analysis of the TB biomarkers. The TB biomarkers were evaluated in both buffer and biological samples, particularly human urine. The most promising and well-known TB biomarker was lipoarabinomannan (LAM), a bacterial cell wall component. In particular, this biomarker detection was validated with clinical samples from TB patients and healthy donors, showing the ability of our POC platform to discriminate those patients with active TB. Moreover, taking advantage of the photonic sensor design, which allows the simultaneous detection of six different biomarkers, we initiated the proof-of-concept of the POC platform for a TB biomarker panel detection using Dip-Pen Nanolithography for each corresponding bioreceptor deposition. Our results, if validated with larger clinical studies, could have important diagnostic implications taking into account the advantages added by our POC biosensor in comparison with the methods recommended by the World Health Organisation.
Universitat Autònoma de Barcelona. Programa de Doctorat en Biotecnologia
Wolozny, Gomez Robelo Daniel Andre. "Additive Manufacturing for Robust and Affordable Medical Devices." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/73295.
Повний текст джерелаPh. D.
Geitner, Nicholas. "A Study of Gold Nanoparticles for Application in Semiconductor CdS Nanosheet Biosensor Devices." Miami University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=miami1311893825.
Повний текст джерелаYeung, Siu Wai. "Development of electrochemistry-based DNA assay in a silicon/glass bio-device for point-of-care applications /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?CENG%202008%20YEUNG.
Повний текст джерелаBéland, Paul. "An Optical Biosensor Towards Urinary Tract Infection Diagnosis." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32881.
Повний текст джерелаBjurström, Johan. "Advanced Thin Film Electroacoustic Devices." Doctoral thesis, Uppsala universitet, Fasta tillståndets elektronik, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7672.
Повний текст джерела