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Статті в журналах з теми "Biomolecular Devices"

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Автор: Grafiati

Опубліковано: 7 вересня 2023

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1

Dey, D., and T. Goswami. "Optical Biosensors: A Revolution Towards Quantum Nanoscale Electronics Device Fabrication." Journal of Biomedicine and Biotechnology 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/348218.

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The dimension of biomolecules is of few nanometers, so the biomolecular devices ought to be of that range so a better understanding about the performance of the electronic biomolecular devices can be obtained at nanoscale. Development of optical biomolecular device is a new move towards revolution of nano-bioelectronics. Optical biosensor is one of such nano-biomolecular devices that has a potential to pave a new dimension of research and device fabrication in the field of optical and biomedical fields. This paper is a very small report about optical biosensor and its development and importance in various fields.

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2

Miró, Jesús M., and Alfonso Rodríguez-Patón. "Biomolecular Computing Devices in Synthetic Biology." International Journal of Nanotechnology and Molecular Computation 2, no. 2 (April 2010): 47–64. http://dx.doi.org/10.4018/978-1-59904-996-0.ch014.

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Synthetic biology and biomolecular computation are disciplines that fuse when it comes to designing and building information processing devices. In this chapter, we study several devices that are representative of this fusion. These are three gene circuits implementing logic gates, a DNA nanodevice and a biomolecular automaton. The operation of these devices is based on gene expression regulation, the so-called competitive hybridization and the workings of certain biomolecules like restriction enzymes or regulatory proteins. Synthetic biology, biomolecular computation, systems biology and standard molecular biology concepts are also defined to give a better understanding of the chapter. The aim is to acquaint readers with these biomolecular devices born of the marriage between synthetic biology and biomolecular computation.

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3

Yoshimine, Hiroshi, Kai Sasaki, and Hiroyuki Furusawa. "Pocketable Biosensor Based on Quartz-Crystal Microbalance and Its Application to DNA Detection." Sensors 23, no. 1 (December 27, 2022): 281. http://dx.doi.org/10.3390/s23010281.

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Quartz-crystal microbalance (QCM) is a technique that can measure nanogram-order masses. When a receptor is immobilized on the sensor surface of a QCM device, the device can detect chemical molecules captured by the mass change. Although QCM devices have been applied to biosensors that detect biomolecules without labels for biomolecular interaction analysis, most highly sensitive QCM devices are benchtop devices. We considered the fabrication of an IC card-sized QCM device that is both portable and battery-powered. Its miniaturization was achieved by repurposing electronic components and film batteries from smartphones and wearable devices. To demonstrate the applicability of the card-sized QCM device as a biosensor, DNA-detection experiments were performed. The card-sized QCM device could detect specific 10-mer DNA chains while discerning single-base differences with a sensitivity similar to that of a conventional benchtop device. The card-sized QCM device can be used in laboratories and in various other fields as a mass sensor.

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4

Malhotra, B. D., and Rahul Singhal. "Conducting polymer based biomolecular electronic devices." Pramana 61, no. 2 (August 2003): 331–43. http://dx.doi.org/10.1007/bf02708313.

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5

Montemagno, Carlo, and George Bachand. "Constructing nanomechanical devices powered by biomolecular motors." Nanotechnology 10, no. 3 (August 12, 1999): 225–31. http://dx.doi.org/10.1088/0957-4484/10/3/301.

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6

Alam, Sadaf R., Pratul K. Agarwal, Melissa C. Smith, Jeffrey S. Vetter, and David Caliga. "Using FPGA Devices to Accelerate Biomolecular Simulations." Computer 40, no. 3 (March 2007): 66–73. http://dx.doi.org/10.1109/mc.2007.108.

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7

Espinosa, Francisco, Manuel Uhlig, and Ricardo Garcia. "Molecular Recognition by Silicon Nanowire Field-Effect Transistor and Single-Molecule Force Spectroscopy." Micromachines 13, no. 1 (January 8, 2022): 97. http://dx.doi.org/10.3390/mi13010097.

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Silicon nanowire (SiNW) field-effect transistors (FETs) have been developed as very sensitive and label-free biomolecular sensors. The detection principle operating in a SiNW biosensor is indirect. The biomolecules are detected by measuring the changes in the current through the transistor. Those changes are produced by the electrical field created by the biomolecule. Here, we have combined nanolithography, chemical functionalization, electrical measurements and molecular recognition methods to correlate the current measured by the SiNW transistor with the presence of specific molecular recognition events on the surface of the SiNW. Oxidation scanning probe lithography (o-SPL) was applied to fabricate sub-12 nm SiNW field-effect transistors. The devices were applied to detect very small concentrations of proteins (500 pM). Atomic force microscopy (AFM) single-molecule force spectroscopy (SMFS) experiments allowed the identification of the protein adsorption sites on the surface of the nanowire. We detected specific interactions between the biotin-functionalized AFM tip and individual avidin molecules adsorbed to the SiNW. The measurements confirmed that electrical current changes measured by the device were associated with the deposition of avidin molecules.

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8

Fujimoto, Keiji. "Design and Synthesis of Biomolecular Devices Using Liposomes." MEMBRANE 30, no. 6 (2005): 293–97. http://dx.doi.org/10.5360/membrane.30.293.

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9

Bachand, George D., Nathan F. Bouxsein, Virginia VanDelinder, and Marlene Bachand. "Biomolecular motors in nanoscale materials, devices, and systems." Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 6, no. 2 (December 11, 2013): 163–77. http://dx.doi.org/10.1002/wnan.1252.

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10

Lara, Sandra, and André Perez-Potti. "Applications of Nanomaterials for Immunosensing." Biosensors 8, no. 4 (November 1, 2018): 104. http://dx.doi.org/10.3390/bios8040104.

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In biomedical science among several other growing fields, the detection of specific biological agents or biomolecular markers, from biological samples is crucial for early diagnosis and decision-making in terms of appropriate treatment, influencing survival rates. In this regard, immunosensors are based on specific antibody-antigen interactions, forming a stable immune complex. The antigen-specific detection antibodies (i.e., biomolecular recognition element) are generally immobilized on the nanomaterial surfaces and their interaction with the biomolecular markers or antigens produces a physico-chemical response that modulates the signal readout. Lowering the detection limits for particular biomolecules is one of the key parameters when designing immunosensors. Thus, their design by combining the specificity and versatility of antibodies with the intrinsic properties of nanomaterials offers a plethora of opportunities for clinical diagnosis. In this review, we show a comprehensive set of recent developments in the field of nanoimmunosensors and how they are progressing the detection and validation for a wide range of different biomarkers in multiple diseases and what are some drawbacks and considerations of the uses of such devices and their expansion.

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11

Bollinger, Terry. "Biomolecular Quantum Computation." Terry's Archive Online 2020, no. 10 (October 22, 2020): 1007. http://dx.doi.org/10.48034/20201007.

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In terms of leveraging the total power of quantum computing, the prevalent current (2020) model of designing quantum computation devices to follow the von Neuman model of abstraction is highly unlikely to be making full use of the full range of computational assistance possible at the atomic and molecular level. This is particularly the case for molecular modeling, in using computational models that more directly leverage the quantum effects of one set of molecules to estimate the behavior of some other set of molecules would remove the bottleneck of insisting that modeling first be converted to the virtual binary or digital format of quantum von Neuman machines. It is argued that even though this possibility of “fighting molecular quantum dynamics with molecular quantum dynamics” was recognized by early quantum computing founders such as Yuri Manin and Richard Feynman, the idea was quickly overlooked in favor of the more computer-compatible model that later developed into qubits and qubit processing.

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12

Palma, Matteo. "(Invited) Controlling CNT-Biomolecule Interfaces -and Their Orientation- to Tune Electrostatic Gating in CNT-Based Biosensing Devices." ECS Meeting Abstracts MA2022-01, no. 8 (July 7, 2022): 679. http://dx.doi.org/10.1149/ma2022-018679mtgabs.

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The development of novel bioelectronics interfaces via the bottom-up assembly of platforms capable of monitoring and exploiting biomolecular interactions with nanoscale control is a central challenge in nanobiotechnology. Biomolecular interactions can be used to electrostatically gate conductance in nanomaterials-based field effect transistors (FETs), but this can be exploited far more effectively than currently done by defining the interface between the biomolecule and the transducer. This strategy forms the basis of greatly improved electrical-based biosensors and offers great potential for building next generation biosensing devices. We will first present different approaches to control the assembly of carbon nanotube (CNT)-protein interfaces towards the fabrication of bioelectronic devices, with a particular focus on the development of real-time biosensors with engineered protein interfacing. We will report the construction of nanoscale protein-based sensing devices designed to present proteins in defined orientations; this allowed us to control the local electrostatic surface presented within the Debye length, and thus modulate the conductance gating effect upon binding incoming protein targets.[1] We systematically tested how protein orientation dictates current response through a CNT-FET device by defining the interface site on the capture protein. Presentation of different protein-protein electrostatic surfaces within the Debye length led either to increase or decrease in conductance: defined and homogenous attachment allows distinctive conductance profiles to be sampled based on the unique electrostatic features of individual proteins, and can support the identification of preferred proteins orientations for optimal sensing. In our case this was done for the detection of a range of concentrations of a class b-lactamase enzymes, that degrade antibiotics, in the context of investigating antimicrobial resistance (AMR). Additionally, we will present the controlled assembly of CNT–GFP hybrids employing DNA as a linker, with protein attachment occurring predominantly at the terminal ends of the nanotubes, as designed.[2] The electronic coupling of the proteins to the nanotubes was confirmed via in-solution fluorescence spectroscopy, that revealed an increase in the emission intensity of GFP when linked to the CNTs. The strategies presented here are of general applicability for the controlled assembly of CNT-protein interfaces toward biosensing and optoelectronics applications. Finally, we will report the tuning of electrostatically gated conductance changes in CNT-aptamer biosensing FETs. We have developed diverse strategies for the construction of such nanoscale devices via in-solution assembly and (self)organization on surfaces. We will discuss how this can lead to distinct conformational changes of the CNT-bound aptamers upon biomarker recognition , leading to opposite electrical response of our biosensors , i.e. increase or decrease in current.[3] These studies highlight the need to define CNT-biomolecule interfaces in order to control and tune by design the electrostatic gating in CNT-based devices, toward the construction of optimized biosensors. [1] Angew. Chem. Int. Ed. 2021, 60, 20184 –20189 [2] Biomolecules 2021, 11(7), 955 [3] in preparation

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13

Bhattacharjee, Abhiroop, Thanh Chien Nguyen, Vivek Pachauri, Sven Ingebrandt, and Xuan Thang Vu. "Comprehensive Understanding of Silicon-Nanowire Field-Effect Transistor Impedimetric Readout for Biomolecular Sensing." Micromachines 12, no. 1 (December 31, 2020): 39. http://dx.doi.org/10.3390/mi12010039.

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Impedance sensing with silicon nanowire field-effect transistors (SiNW-FETs) shows considerable potential for label-free detection of biomolecules. With this technique, it might be possible to overcome the Debye-screening limitation, a major problem of the classical potentiometric readout. We employed an electronic circuit model in Simulation Program with Integrated Circuit Emphasis (SPICE) for SiNW-FETs to perform impedimetric measurements through SPICE simulations and quantitatively evaluate influences of various device parameters to the transfer function of the devices. Furthermore, we investigated how biomolecule binding to the surface of SiNW-FETs is influencing the impedance spectra. Based on mathematical analysis and simulation results, we proposed methods that could improve the impedimetric readout of SiNW-FET biosensors and make it more explicable.

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14

Akbulut, Ozge, Arum Amy Yu, and Francesco Stellacci. "Fabrication of biomolecular devices via supramolecular contact-based approaches." Chem. Soc. Rev. 39, no. 1 (2010): 30–37. http://dx.doi.org/10.1039/b915558a.

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15

RINALDI, ROSS, EMANUELA BRANCA, ROBERTO CINGOLANI, ROSA FELICE, ARRIGO CALZOLARI, ELISA MOLINARI, SALVATORE MASIERO, GIANPIERO SPADA, GIOVANNI GOTTARELLI, and ANNA GARBESI. "Biomolecular Electronic Devices Based on Self-Organized Deoxyguanosine Nanocrystals." Annals of the New York Academy of Sciences 960, no. 1 (January 24, 2006): 184–92. http://dx.doi.org/10.1111/j.1749-6632.2002.tb03033.x.

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16

Reif, John H., and Thomas H. LaBean. "Autonomous programmable biomolecular devices using self-assembled DNA nanostructures." Communications of the ACM 50, no. 9 (September 2007): 46–53. http://dx.doi.org/10.1145/1284621.1284647.

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17

Hess, H. "MATERIALS SCIENCE: Enhanced: Toward Devices Powered by Biomolecular Motors." Science 312, no. 5775 (May 12, 2006): 860–61. http://dx.doi.org/10.1126/science.1126399.

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18

Miller, Benjamin S., Claudio Parolo, Valérian Turbé, Candice E. Keane, Eleanor R. Gray, and Rachel A. McKendry. "Quantifying Biomolecular Binding Constants using Video Paper Analytical Devices." Chemistry - A European Journal 24, no. 39 (June 8, 2018): 9783–87. http://dx.doi.org/10.1002/chem.201802394.

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19

BYON, HYE RYUNG, SUPHIL KIM, and HEE CHEUL CHOI. "LABEL-FREE BIOMOLECULAR DETECTION USING CARBON NANOTUBE FIELD EFFECT TRANSISTORS." Nano 03, no. 06 (December 2008): 415–31. http://dx.doi.org/10.1142/s1793292008001404.

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Carbon nanotube field effect transistor (FET) type biosensors have been widely investigated as one of the promising platforms for highly sensitive personalized disease-monitoring electronic devices. Combined with high level cutting edge information technology (IT) infra systems, carbon nanotube transistor biosensors afford a great opportunity to contribute to human disease care by providing early diagnostic capability. Several key prerequisites that should be clarified for the real application include sensitivity, reliability, reproducibility, and expandability to multiplex detection systems. In this brief review, we introduce the types, fabrication, and detection methods of single-walled carbon nanotube FET (SWNT-FET) devices. As surface functionalization of the devices by which nonspecific bindings (NSBs) are efficiently prohibited is also another important issue regarding reliable biosensors, we discuss several key strategies about surface passivation along with examples of various biomolecules such as proteins, DNA, small molecules, aptamers, viruses, and cancer and neurodegenerative disease markers which have been successfully sensed by SWNT-FET devices. Finally, we discuss proposed detection mechanisms, according to which strategies for fabricating sensor devices having high sensitivity are determined. Two main mechanisms — charge transfer (or electrostatic gate effect) and Schottky barrier effect, depending on the place where biomolecules are adsorbed — will be covered.

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20

Han, Aoze, Liwei Zhang, Miaocheng Zhang, Cheng Liu, Rongrong Wu, Yixin Wei, Ronghui Dan, et al. "Amyloid–Gold Nanoparticle Hybrids for Biocompatible Memristive Devices." Materials 16, no. 5 (February 24, 2023): 1884. http://dx.doi.org/10.3390/ma16051884.

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Biomolecular materials offer tremendous potential for the development of memristive devices due to their low cost of production, environmental friendliness, and, most notably, biocompatibility. Herein, biocompatible memristive devices based on amyloid–gold nanoparticle hybrids have been investigated. These memristors demonstrate excellent electrical performance, featuring an ultrahigh Roff/Ron ratio (>107), a low switching voltage (<0.8 V), and reliable reproducibility. Additionally, the reversible transition from threshold switching to resistive switching mode was achieved in this work. The arrangement of peptides in amyloid fibrils endows the surface polarity and phenylalanine packing, which provides channels for the migration of Ag ions in the memristors. By modulating voltage pulse signals, the study successfully imitates the synaptic behavior of excitatory postsynaptic current (EPSC), paired-pulse facilitation (PPF), and the transition from short-term plasticity (STP) to long-term plasticity (LTP). More interestingly, Boolean logic standard cells were designed and simulated using the memristive devices. The fundamental and experimental results of this study thus offer insights into the utilization of biomolecular materials for advanced memristive devices.

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21

Katz, Evgeny, and Sergiy Minko. "Enzyme-based logic systems interfaced with signal-responsive materials and electrodes." Chemical Communications 51, no. 17 (2015): 3493–500. http://dx.doi.org/10.1039/c4cc09851j.

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22

Danelon, Christophe, Martin G. Jenke, Christoph Schreiter, Gyu Man Kim, Jean-Baptiste Perez, Christian Santschi, Jürgen Brugger, and Horst Vogel. "Micro- and Nanostructured Devices for the Investigation of Biomolecular Interactions." CHIMIA International Journal for Chemistry 60, no. 11 (November 29, 2006): 754–60. http://dx.doi.org/10.2533/chimia.2006.754.

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23

Grove, T. J., K. A. Puckett, N. M. Brunet, G. Mihajlovic, L. A. McFadden, Peng Xiong, S. von Molnar, T. S. Moerland, and P. B. Chase. "Packaging actomyosin-based biomolecular motor-driven devices for nanoactuator applications." IEEE Transactions on Advanced Packaging 28, no. 4 (November 2005): 556–63. http://dx.doi.org/10.1109/tadvp.2005.858341.

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24

Arya, Sunil K., Pratima R. Solanki, Monika Datta, and Bansi D. Malhotra. "Recent advances in self-assembled monolayers based biomolecular electronic devices." Biosensors and Bioelectronics 24, no. 9 (May 2009): 2810–17. http://dx.doi.org/10.1016/j.bios.2009.02.008.

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25

Lin, Chih-Ting, Ming-Tse Kao, Katsuo Kurabayashi, and Edgar Meyhöfer. "Efficient Designs for Powering Microscale Devices with Nanoscale Biomolecular Motors." Small 2, no. 2 (February 2006): 281–87. http://dx.doi.org/10.1002/smll.200500153.

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26

Osborn Popp, Thomas M., Brandon T. Matchett, Rashawn G. Green, Insha Chhabra, Smriti Mumudi, Ashley D. Bernstein, Jacqueline R. Perodeau, and Andrew J. Nieuwkoop. "3D-Printable centrifugal devices for biomolecular solid state NMR rotors." Journal of Magnetic Resonance 354 (September 2023): 107524. http://dx.doi.org/10.1016/j.jmr.2023.107524.

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27

Varade, Vaibhav, Tal Markus, Kiran Vankayala, Noga Friedman, Mordechai Sheves, David H. Waldeck, and Ron Naaman. "Bacteriorhodopsin based non-magnetic spin filters for biomolecular spintronics." Physical Chemistry Chemical Physics 20, no. 2 (2018): 1091–97. http://dx.doi.org/10.1039/c7cp06771b.

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We discuss spin injection and spin valves, which are based on organic and biomolecules, that offer the possibility to overcome some of the limitations of solid-state devices, which are based on ferromagnetic metal electrodes.

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28

Hejazian, Majid, Eugeniu Balaur, and Brian Abbey. "Recent Advances and Future Perspectives on Microfluidic Mix-and-Jet Sample Delivery Devices." Micromachines 12, no. 5 (May 7, 2021): 531. http://dx.doi.org/10.3390/mi12050531.

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The integration of the Gas Dynamic Virtual Nozzle (GDVN) and microfluidic technologies has proven to be a promising sample delivery solution for biomolecular imaging studies and has the potential to be transformative for a range of applications in physics, biology, and chemistry. Here, we review the recent advances in the emerging field of microfluidic mix-and-jet sample delivery devices for the study of biomolecular reaction dynamics. First, we introduce the key parameters and dimensionless numbers involved in their design and characterisation. Then we critically review the techniques used to fabricate these integrated devices and discuss their advantages and disadvantages. We then summarise the most common experimental methods used for the characterisation of both the mixing and jetting components. Finally, we discuss future perspectives on the emerging field of microfluidic mix-and-jet sample delivery devices. In summary, this review aims to introduce this exciting new topic to the wider microfluidics community and to help guide future research in the field.

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29

Costantini, Francesca, Nicola Lovecchio, Manasa Nandimandalam, Ariana Manglli, Francesco Faggioli, Mara Biasin, Cesare Manetti, et al. "Biomolecular Monitoring Tool Based on Lab-on-Chip for Virus Detection." Biosensors 13, no. 5 (May 12, 2023): 544. http://dx.doi.org/10.3390/bios13050544.

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Lab-on-Chip (LoC) devices for performing real-time PCR are advantageous compared to standard equipment since these systems allow to conduct in-field quick analysis. The development of LoCs, where the components for performing the nucleic acid amplification are all integrated, can be an issue. In this work, we present a LoC-PCR device where thermalization, temperature control and detection elements are all integrated on a single glass substrate named System-on-Glass (SoG) obtained using metal thin-film deposition. By using a microwell plate optically coupled with the SoG, real-time reverse transcriptase PCR of RNA extracted from both a plant and human virus has been carried out in the developed LoC-PCR device. The limit of detection and time of analysis for the detection of the two viruses by using the LoC-PCR were compared with those achieved by standard equipment. The results showed that the two systems can detect the same concentration of RNA; however, the LoC-PCR performs the analysis in half of the time compared to the standard thermocycler, with the advantage of the portability, leading to a point-of-care device for several diagnostic applications.

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30

Loos, Remco, and Bendek Nagy. "On the Concepts of Parallelism in Biomolecular Computing." Triangle, no. 6 (June 28, 2018): 109. http://dx.doi.org/10.17345/triangle6.109-118.

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In this paper we consider DNA and membrane computing, both as theoretical models and as problem solving devices. The basic motivation behind these models of natural computing is using parallelism to make hard problems tractable. In this paper we analyze the concept of parallelism. We will show that parallelism has very different meanings in these models.We introduce the terms ’or-parallelism’ and ’and-parallelism’ for these two basic types of parallelism.

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31

Smutok, Oleh, and Evgeny Katz. "Biosensors: Electrochemical Devices—General Concepts and Performance." Biosensors 13, no. 1 (December 28, 2022): 44. http://dx.doi.org/10.3390/bios13010044.

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This review provides a general overview of different biosensors, mostly concentrating on electrochemical analytical devices, while briefly explaining general approaches to various kinds of biosensors, their construction and performance. A discussion on how all required components of biosensors are brought together to perform analytical work is offered. Different signal-transducing mechanisms are discussed, particularly addressing the immobilization of biomolecular components in the vicinity of a transducer interface and their functional integration with electronic devices. The review is mostly addressing general concepts of the biosensing processes rather than specific modern achievements in the area.

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32

SASAKI, Naoki. "Recent Applications of AC Electrokinetics in Biomolecular Analysis on Microfluidic Devices." Analytical Sciences 28, no. 1 (2012): 3. http://dx.doi.org/10.2116/analsci.28.3.

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33

Kang, Di, Ryan J. White, Fan Xia, Xiaolei Zuo, Alexis Vallée-Bélisle, and Kevin W. Plaxco. "DNA biomolecular-electronic encoder and decoder devices constructed by multiplex biosensors." NPG Asia Materials 4, no. 1 (January 2012): e1-e1. http://dx.doi.org/10.1038/am.2012.1.

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34

Ottova-Leitmannova, A., and H. Ti Tien. "Bilayer lipid membranes: An experimental system for biomolecular electronic devices development." Progress in Surface Science 41, no. 4 (December 1992): 337–445. http://dx.doi.org/10.1016/0079-6816(92)90012-7.

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35

Romera, David, Pierre Couleaud, Sara H. Mejias, Antonio Aires, and Aitziber L. Cortajarena. "Biomolecular templating of functional hybrid nanostructures using repeat protein scaffolds." Biochemical Society Transactions 43, no. 5 (October 1, 2015): 825–31. http://dx.doi.org/10.1042/bst20150077.

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The precise synthesis of materials and devices with tailored complex structures and properties is a requisite for the development of the next generation of products based on nanotechnology. Nowadays, the technology for the generation of this type of devices lacks the precision to determine their properties and is accomplished mostly by ‘trial and error’ experimental approaches. The use of bottom-up approaches that rely on highly specific biomolecular interactions of small and simple components is an attractive approach for the templating of nanoscale elements. In nature, protein assemblies define complex structures and functions. Engineering novel bio-inspired assemblies by exploiting the same rules and interactions that encode the natural diversity is an emerging field that opens the door to create nanostructures with numerous potential applications in synthetic biology and nanotechnology. Self-assembly of biological molecules into defined functional structures has a tremendous potential in nano-patterning and the design of novel materials and functional devices. Molecular self-assembly is a process by which complex 3D structures with specified functions are constructed from simple molecular building blocks. Here we discuss the basis of biomolecular templating, the great potential of repeat proteins as building blocks for biomolecular templating and nano-patterning. In particular, we focus on the designed consensus tetratricopeptide repeats (CTPRs), the control on the assembly of these proteins into higher order structures and their potential as building blocks in order to generate functional nanostructures and materials.

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Digiacomo, Luca, Sara Palchetti, Francesca Giulimondi, Daniela Pozzi, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Aldo Laganà, and Giulio Caracciolo. "The biomolecular corona of gold nanoparticles in a controlled microfluidic environment." Lab on a Chip 19, no. 15 (2019): 2557–67. http://dx.doi.org/10.1039/c9lc00341j.

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ABADIR, G. B., K. WALUS, R. F. B. TURNER, and D. L. PULFREY. "BIOMOLECULAR SENSING USING CARBON NANOTUBES: A SIMULATION STUDY." International Journal of High Speed Electronics and Systems 18, no. 04 (December 2008): 879–87. http://dx.doi.org/10.1142/s0129156408005849.

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A simulation study using molecular dynamics and the density-functional-theory/non-equilibrium-Green's-function approach has been carried out to investigate the potential of carbon nanotubes (CNT) as molecular-scale biosensors. Single molecules of each of two amino acids (isoleucine and asparagine) were used as the target molecules in two separate simulations. The results show a significant suppression of the local density of states (LDOS) in both cases, with a distinct response for each molecule. This is promising for the prospect of CNT-based single-molecule sensors that might depend on the LDOS, e.g., devices that respond to changes in either conductance or electroluminescence.

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Ben-Jacob, E., Z. Hermon, and S. Caspi. "DNA transistor and quantum bit element: Realization of nano-biomolecular logical devices." Physics Letters A 263, no. 3 (November 1999): 199–202. http://dx.doi.org/10.1016/s0375-9601(99)00734-3.

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Humayun, Q., and U. Hashim. "A Brief Review of the Current Technologies Used for the Fabrication of Metal-Molecule-Metal Junction Electrodes." Advanced Materials Research 626 (December 2012): 867–77. http://dx.doi.org/10.4028/www.scientific.net/amr.626.867.

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Fabrication techniques for Metal-molecule-metal junction electrodes suitable to study electron tunneling through metal junctions are reviewed. The applications of current technologies such as mechanical break junction, electromigration, shadow mask lithography, focused ion beam deposition, chemical and electrochemical plating, electron-beam lithography, in fabricating vacant junction electrodes are briefly described. For biomolecular sensing applications, the size of the junction electrodes must be small enough to allow the biomolecule inserted into the junction space to connect both leads to keep the molecules in a relaxed and undistorted state. A significant advantage of using Metal-molecule-metal junction electrodes devices is that the junction can be characterized with and without the molecule in place. Any electrical artifacts introduced by the electrode fabrication process are more easily deconvoluted from the intrinsic properties of the molecule.

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Renner, Julie N. "(Invited) Biomolecular Engineering for Electrochemical Applications in Fuel Cells/Electrolyzers and Beyond." ECS Meeting Abstracts MA2022-02, no. 46 (October 9, 2022): 1713. http://dx.doi.org/10.1149/ma2022-02461713mtgabs.

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Control of ionomer thin film structures on metal surfaces is pivotal for efficient performance in electrochemical devices such as fuel cells and electrolyzers. Unfortunately, the assembly of these thin film structures is difficult to control using conventional methods and ideal arrangements remain unknown. Engineered polypeptides have emerged as powerful biomolecular tools in electrode assembly because binding sites and polypeptide structures can be easily modulated by changing the amino acid sequence. However, no studies have been conducted showing polypeptides can be engineered to interact with ionomers, attach them to metal surfaces, and control their arrangement. Our lab has recently developed this technology, using an elastin-like polypeptide to bind to metals, and bind to acidic and basic ionomer via ionic interactions. We use a quartz crystal microbalance with dissipation to provide detailed information about the loading, thickness, and binding behavior of the polypeptide and ionomer layers. We also use atomic force microscopy and grazing-incidence small-angle X-ray scattering to understand the impact of the biomolecules on ionomer phase separation. Finally, we have analyzed the performance (ionic conductivity) of the assembled films using interdigitated electrodes and electrochemical impedance spectroscopy. Through these techniques, we show that 1) our biomolecular system is highly flexible, easily adapting to different materials, 2) the polypeptide sequence can dictate ionomer phase separated structures, and 3) this system can be used to improve the performance of ionomer thin films and gain structure-function understanding. Generally, our results demonstrate that engineered polypeptides are promising tools for ionomer control in electrode engineering for fuel cells/electrolyzers and beyond. Furthermore, this work demonstrates that the creative combination of applied electrochemistry and biomolecular engineering supported and encouraged by leaders in each field can lead to unique research pathways that benefit heath, energy and the environment.

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Nguyen, Dang Du, Seho Lee, and Inki Kim. "Recent Advances in Metaphotonic Biosensors." Biosensors 13, no. 6 (June 7, 2023): 631. http://dx.doi.org/10.3390/bios13060631.

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Metaphotonic devices, which enable light manipulation at a subwavelength scale and enhance light–matter interactions, have been emerging as a critical pillar in biosensing. Researchers have been attracted to metaphotonic biosensors, as they solve the limitations of the existing bioanalytical techniques, including the sensitivity, selectivity, and detection limit. Here, we briefly introduce types of metasurfaces utilized in various metaphotonic biomolecular sensing domains such as refractometry, surface-enhanced fluorescence, vibrational spectroscopy, and chiral sensing. Further, we list the prevalent working mechanisms of those metaphotonic bio-detection schemes. Furthermore, we summarize the recent progress in chip integration for metaphotonic biosensing to enable innovative point-of-care devices in healthcare. Finally, we discuss the impediments in metaphotonic biosensing, such as its cost effectiveness and treatment for intricate biospecimens, and present a prospect for potential directions for materializing these device strategies, significantly influencing clinical diagnostics in health and safety.

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Spillmann, Christopher M., and Igor L. Medintz. "Use of biomolecular scaffolds for assembling multistep light harvesting and energy transfer devices." Journal of Photochemistry and Photobiology C: Photochemistry Reviews 23 (June 2015): 1–24. http://dx.doi.org/10.1016/j.jphotochemrev.2014.12.002.

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Park, Seung-min, Yun Suk Huh, Harold G. Craighead, and David Erickson. "A method for nanofluidic device prototyping using elastomeric collapse." Proceedings of the National Academy of Sciences 106, no. 37 (August 27, 2009): 15549–54. http://dx.doi.org/10.1073/pnas.0904004106.

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Nanofluidics represents a promising solution to problems in fields ranging from biomolecular analysis to optical property tuning. Recently a number of simple nanofluidic fabrication techniques have been introduced that exploit the deformability of elastomeric materials like polydimethylsiloxane (PDMS). These techniques are limited by the complexity of the devices that can be fabricated, which can only create straight or irregular channels normal to the direction of an applied strain. Here, we report a technique for nanofluidic fabrication based on the controlled collapse of microchannel structures. As is demonstrated, this method converts the easy to control vertical dimension of a PDMS mold to the lateral dimension of a nanochannel. We demonstrate here the creation of complex nanochannel structures as small as 60 nm and provide simple design rules for determining the conditions under which nanochannel formation will occur. The applicability of the technique to biomolecular analysis is demonstrated by showing DNA elongation in a nanochannel and a technique for optofluidic surface enhanced Raman detection of nucleic acids.

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44

Hattori, Mitsuru, Sumito Shirane, Tomoki Matsuda, Kuniaki Nagayama, and Takeharu Nagai. "Smartphone-Based Portable Bioluminescence Imaging System Enabling Observation at Various Scales from Whole Mouse Body to Organelle." Sensors 20, no. 24 (December 14, 2020): 7166. http://dx.doi.org/10.3390/s20247166.

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Current smartphones equipped with high-sensitivity and high-resolution sensors in the camera can respond to the needs of low-light imaging, streaming acquisition, targets of various scales, etc. Therefore, a smartphone has great potential as an imaging device even in the scientific field and has already been introduced into biomolecular imaging using fluorescence tags. However, owing to the necessity of an excitation light source, fluorescence methods impair its mobility. Bioluminescence does not require illumination; therefore, imaging with a smartphone camera is compact and requires minimal devices, thus making it suitable for personal and portable imaging devices. Here, we report smartphone-based methods to observe biological targets in various scales using bioluminescence. In particular, we demonstrate, for the first time, that bioluminescence can be observed in an organelle in a single living cell using a smartphone camera by attaching a detachable objective lens. Through capturing color changes with the camera, changes in the amount of target molecules was detected using bioluminescent indicators. The combination of bioluminescence and a mobile phone makes possible a compact imaging system without an external light source and expands the potential of portable devices.

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Jeon, Won Jin, Chee Burm Shin, and Jong Heop Yi. "Fabrication of a Microfluidic Device for the Detection of a Specific Biomolecule." Advances in Science and Technology 57 (September 2008): 105–10. http://dx.doi.org/10.4028/www.scientific.net/ast.57.105.

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Mutation and aggregation of superoxide dismutase (SOD) are reported as one of the causes of amyotrophic lateral sclerosis (ALS). To detect SOD1 protein from the motor neuron, surface plasmon resonance (SPR) analysis was adopted due to its advantages in the in-situ biomolecular recognition by surface analysis without labeling. For the patterning of protein antigens at Au surface for use in SPR imaging experiments, microfluidic devices were fabricated with polydimethylsiloxane (PDMS) by replica molding method. They were designed for the solution to flow by capillary force only without using any additional pumping equipments or flow controllers. Performance of microfluidic devices was verified by the simple microfluidic experiments, and multiple protein-patterned sensor surfaces were constructed by using these microfluidic devices.

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46

Xu, Yujie, Hang Zhou, Pengyi Duan, Baojie Shan, Wenjing Xu, Jian Wang, Mei Liu, Fujun Zhang, and Qianqian Sun. "Improving the Efficiency of Organic Solar Cells with Methionine as Electron Transport Layer." Molecules 27, no. 19 (September 27, 2022): 6363. http://dx.doi.org/10.3390/molecules27196363.

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Interface modification is an important way to get better performance from organic solar cells (OSCs). A natural biomolecular material methionine was successfully applied as the electron transport layer (ETL) to the inverted OSCs in this work. A series of optical, morphological, and electrical characterizations of thin films and devices were used to analyze the surface modification effects of methionine on zinc oxide (ZnO). The analysis results show that the surface modification of ZnO with methionine can cause significantly reduced surface defects for ZnO, optimized surface morphology of ZnO, improved compatibility between ETL and the active layer, better-matched energy levels between ETL and the acceptor, reduced interface resistance, reduced charge recombination, and enhanced charge transport and collection. The power conversion efficiency (PCE) of OSCs based on PM6:BTP-ec9 was improved to 15.34% from 14.25% by modifying ZnO with methionine. This work shows the great application potential of natural biomolecule methionine in OSCs.

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Soong, Ricky, and Carlo Montemagno. "Engineering hybrid nano-devices powered by the F_{1-ATPase biomolecular motor}." International Journal of Nanotechnology 2, no. 4 (2005): 371. http://dx.doi.org/10.1504/ijnt.2005.008075.

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Arata, Hideyuki F., Hiroyuki Noji, and Hiroyuki Fujita. "Motion control of single F1-ATPase rotary biomolecular motor using microfabricated local heating devices." Applied Physics Letters 88, no. 8 (February 20, 2006): 083902. http://dx.doi.org/10.1063/1.2177374.

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Arata, Hideyuki F., and Hiroyuki Fujita. "Miniaturized thermocontrol devices enable analysis of biomolecular behavior on their timescales, second to millisecond." Integrative Biology 1, no. 5-6 (2009): 363. http://dx.doi.org/10.1039/b901902b.

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Biasco, A., G. Maruccio, P. Visconti, A. Bramanti, P. Calogiuri, R. Cingolani, and R. Rinaldi. "Self-chemisorption of azurin on functionalized oxide surfaces for the implementation of biomolecular devices." Materials Science and Engineering: C 24, no. 4 (June 2004): 563–67. http://dx.doi.org/10.1016/j.msec.2004.02.006.

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