Готові списки джерел за темами / Biomedical Device Fabrication

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Автор: Grafiati
Опубліковано: 7 вересня 2023

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Статті в журналах з теми "Biomedical Device Fabrication"

1

Shin, Yoo-Kyum, Yujin Shin, Jung Woo Lee, and Min-Ho Seo. "Micro-/Nano-Structured Biodegradable Pressure Sensors for Biomedical Applications." Biosensors 12, no. 11 (November 1, 2022): 952. http://dx.doi.org/10.3390/bios12110952.

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The interest in biodegradable pressure sensors in the biomedical field is growing because of their temporary existence in wearable and implantable applications without any biocompatibility issues. In contrast to the limited sensing performance and biocompatibility of initially developed biodegradable pressure sensors, device performances and functionalities have drastically improved owing to the recent developments in micro-/nano-technologies including device structures and materials. Thus, there is greater possibility of their use in diagnosis and healthcare applications. This review article summarizes the recent advances in micro-/nano-structured biodegradable pressure sensor devices. In particular, we focus on the considerable improvement in performance and functionality at the device-level that has been achieved by adapting the geometrical design parameters in the micro- and nano-meter range. First, the material choices and sensing mechanisms available for fabricating micro-/nano-structured biodegradable pressure sensor devices are discussed. Then, this is followed by a historical development in the biodegradable pressure sensors. In particular, we highlight not only the fabrication methods and performances of the sensor device, but also their biocompatibility. Finally, we intoduce the recent examples of the micro/nano-structured biodegradable pressure sensor for biomedical applications.
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2

Bais, Ashish Singh, Lokendra Singh Chouhan, and Joseph Thomas Andrews. "All Optical Integrated MOEMS Optical Coherence Tomography System." Journal of Physics: Conference Series 2426, no. 1 (February 1, 2023): 012024. http://dx.doi.org/10.1088/1742-6596/2426/1/012024.

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Abstract Integrating all optical components of an optical coherence tomography (OCT) device into a single chip is non-trivial and a challenging job. The design and development of such a lab-on-a chip is possible only via Micro-Opto-Electro-Mechanical System (MOEMS) technology. The reproducible and integrated optical device fabrication would reduce cost and size many folds as compared to bulk or fiber optic OCT system. A miniaturized OCT of size less than 5mm2 area is designed, simulated, and optimized. The successful fabrication of this device would help in point-of-contact devices as well as embedded biomedical sensor applications. Also, the design promises the possibility of fabrication of all optical components of OCT integrated into a single chip.
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3

Dey, D., and T. Goswami. "Optical Biosensors: A Revolution Towards Quantum Nanoscale Electronics Device Fabrication." Journal of Biomedicine and Biotechnology 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/348218.

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The dimension of biomolecules is of few nanometers, so the biomolecular devices ought to be of that range so a better understanding about the performance of the electronic biomolecular devices can be obtained at nanoscale. Development of optical biomolecular device is a new move towards revolution of nano-bioelectronics. Optical biosensor is one of such nano-biomolecular devices that has a potential to pave a new dimension of research and device fabrication in the field of optical and biomedical fields. This paper is a very small report about optical biosensor and its development and importance in various fields.
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4

Giorleo, L., E. Ceretti, and C. Giardini. "Optimization of laser micromachining process for biomedical device fabrication." International Journal of Advanced Manufacturing Technology 82, no. 5-8 (June 27, 2015): 901–7. http://dx.doi.org/10.1007/s00170-015-7450-2.

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Li, Qiushi, Zhaoduo Tong, and Hongju Mao. "Microfluidic Based Organ-on-Chips and Biomedical Application." Biosensors 13, no. 4 (March 29, 2023): 436. http://dx.doi.org/10.3390/bios13040436.

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6

Garcia-Rey, Sandra, Jacob B. Nielsen, Gregory P. Nordin, Adam T. Woolley, Lourdes Basabe-Desmonts, and Fernando Benito-Lopez. "High-Resolution 3D Printing Fabrication of a Microfluidic Platform for Blood Plasma Separation." Polymers 14, no. 13 (June 22, 2022): 2537. http://dx.doi.org/10.3390/polym14132537.

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Анотація:
Additive manufacturing technology is an emerging method for rapid prototyping, which enables the creation of complex geometries by one-step fabrication processes through a layer-by-layer approach. The simplified fabrication achieved with this methodology opens the way towards a more efficient industrial production, with applications in a great number of fields such as biomedical devices. In biomedicine, blood is the gold-standard biofluid for clinical analysis. However, blood cells generate analytical interferences in many test procedures; hence, it is important to separate plasma from blood cells before analytical testing of blood samples. In this research, a custom-made resin formulation combined with a high-resolution 3D printing methodology were used to achieve a methodology for the fast prototype optimization of an operative plasma separation modular device. Through an iterative process, 17 different prototypes were designed and fabricated with printing times ranging from 5 to 12 min. The final device was evaluated through colorimetric analysis, validating this fabrication approach for the qualitative assessment of plasma separation from whole blood. The 3D printing method used here demonstrates the great contribution that this microfluidic technology will bring to the plasma separation biomedical devices market.
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Wu, Zhen-Lin, Ya-Nan Qi, Xiao-Jie Yin, Xin Yang, Chang-Ming Chen, Jing-Ying Yu, Jia-Chen Yu, et al. "Polymer-Based Device Fabrication and Applications Using Direct Laser Writing Technology." Polymers 11, no. 3 (March 22, 2019): 553. http://dx.doi.org/10.3390/polym11030553.

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Polymer materials exhibit unique properties in the fabrication of optical waveguide devices, electromagnetic devices, and bio-devices. Direct laser writing (DLW) technology is widely used for micro-structure fabrication due to its high processing precision, low cost, and no need for mask exposure. This paper reviews the latest research progresses of polymer-based micro/nano-devices fabricated using the DLW technique as well as their applications. In order to realize various device structures and functions, different manufacture parameters of DLW systems are adopted, which are also investigated in this work. The flexible use of the DLW process in various polymer-based microstructures, including optical, electronic, magnetic, and biomedical devices are reviewed together with their applications. In addition, polymer materials which are developed with unique properties for the use of DLW technology are also discussed.
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Butkutė, Agnė, Tomas Jurkšas, Tomas Baravykas, Bettina Leber, Greta Merkininkaitė, Rugilė Žilėnaitė, Deividas Čereška, et al. "Combined Femtosecond Laser Glass Microprocessing for Liver-on-Chip Device Fabrication." Materials 16, no. 6 (March 8, 2023): 2174. http://dx.doi.org/10.3390/ma16062174.

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Nowadays, lab-on-chip (LOC) devices are attracting more and more attention since they show vast prospects for various biomedical applications. Usually, an LOC is a small device that serves a single laboratory function. LOCs show massive potential for organ-on-chip (OOC) device manufacturing since they could allow for research on the avoidance of various diseases or the avoidance of drug testing on animals or humans. However, this technology is still under development. The dominant technique for the fabrication of such devices is molding, which is very attractive and efficient for mass production, but has many drawbacks for prototyping. This article suggests a femtosecond laser microprocessing technique for the prototyping of an OOC-type device—a liver-on-chip. We demonstrate the production of liver-on-chip devices out of glass by using femtosecond laser-based selective laser etching (SLE) and laser welding techniques. The fabricated device was tested with HepG2(GS) liver cancer cells. During the test, HepG2(GS) cells proliferated in the chip, thus showing the potential of the suggested technique for further OOC development.
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Elvira, Katherine S., Fabrice Gielen, Scott S. H. Tsai, and Adrian M. Nightingale. "Materials and methods for droplet microfluidic device fabrication." Lab on a Chip 22, no. 5 (2022): 859–75. http://dx.doi.org/10.1039/d1lc00836f.

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When making a droplet flow device what material should you use? What fabrication methods are available and will surface treatments be required? This review offers a guide, with examples, to making robust droplet flow devices.
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Perumal, Veeradasan, U. Hashim, and Tijjani Adam. "Mask Design and Simulation: Computer Aided Design for Lab-on-Chip Application." Advanced Materials Research 832 (November 2013): 84–88. http://dx.doi.org/10.4028/www.scientific.net/amr.832.84.

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A simple design and simulation of microwire, contact pad and microfluidic channel on computer aided design (CAD) for chrome mask fabrication are described.The integration of microfluidic and nanotechnology for miniaturized lab-on-chip device has received a large research attention due to its undisputable and widespread biomedical applications. For the development of a micro-total analytical system, the integration of an appropriate fluid delivery system to a biosensing apparatus is required. In this study, we had presented the new Lab-On-Chip design for biomedical application. AutoCAD software was used to present the initial design/prototype of this Lab-On-Chip device. The microfluidic is design in such a way, that fluid flow was passively driven by capillary effect. Eventually, the prototype of the microfluidics was simulated using Comsol Multiphysics software for design validation.The complete design upon simulation is then used for mask fabrication. Hence, three mask is fabricated which consist of microwire, contact pad and microfluidics for device fabrication using photolithography process.
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Дисертації з теми "Biomedical Device Fabrication"

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Chopra, Pooja. "Fabrication of Multi-Parallel Microfluidic Devices for Investigating MechanicalProperties of Cancer Cells." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1466594229.

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Ung, Ryan. "The Design, Fabrication, and Testing of a Point of Care Device for Diagnosing Sickle Cell Disease and Other Hemoglobin Disorders." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1459188452.

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Shah, Pratikkumar. "Development of a Lab-on-a-Chip Device for Rapid Nanotoxicity Assessment In Vitro." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1834.

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Анотація:
Increasing useof nanomaterials in consumer products and biomedical applications creates the possibilities of intentional/unintentional exposure to humans and the environment. Beyond the physiological limit, the nanomaterialexposure to humans can induce toxicity. It is difficult to define toxicity of nanoparticles on humans as it varies by nanomaterialcomposition, size, surface properties and the target organ/cell line. Traditional tests for nanomaterialtoxicity assessment are mostly based on bulk-colorimetric assays. In many studies, nanomaterials have found to interfere with assay-dye to produce false results and usually require several hours or days to collect results. Therefore, there is a clear need for alternative tools that can provide accurate, rapid, and sensitive measure of initial nanomaterialscreening. Recent advancement in single cell studies has suggested discovering cell properties not found earlier in traditional bulk assays. A complex phenomenon, like nanotoxicity, may become clearer when studied at the single cell level, including with small colonies of cells. Advances in lab-on-a-chip techniques have played a significant role in drug discoveries and biosensor applications, however, rarely explored for nanomaterialtoxicity assessment. We presented such cell-integrated chip-based approach that provided quantitative and rapid response of cellhealth, through electrochemical measurements. Moreover, the novel design of the device presented in this study was capable of capturing and analyzing the cells at a single cell and small cell-population level. We examined the change in exocytosis (i.e. neurotransmitterrelease) properties of a single PC12 cell, when exposed to CuOand TiO2 nanoparticles. We found both nanomaterials to interfere with the cell exocytosis function. We also studied the whole-cell response of a single-cell and a small cell-population simultaneously in real-time for the first time. The presented study can be a reference to the future research in the direction of nanotoxicity assessment to develop miniature, simple, and cost-effective tool for fast, quantitative measurements at high throughput level. The designed lab-on-a-chip device and measurement techniques utilized in the present work can be applied for the assessment of othernanoparticles' toxicity, as well.
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4

Kong, Tiantian, and 孔湉湉. "Microfluidic fabrication of polymer-based microparticles for biomedical applications." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196008.

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Delivery vehicles that can encapsulate and release active ingredients of pre-determined volumes at the target site on-demand present a challenge in biomedical field. Due to their tunable physiochemical properties and degradation rate, polymeric particles are one of the most extensively employed delivery vehicles. Generally they are fabricated from emulsion templates. Conventional bulk emulsification technique provides little control over the characteristics of droplets generated. Thus the properties of the subsequent particles cannot be controlled. The advance of droplet microfluidics enables the generation and manipulation of designer single, double or higher-order emulsion droplets with customizable structure. These droplets are powerful and versatile templates for fabricating polymeric delivery vehicles with pre-determined properties. Due to the monodispersity of droplet templates by microfluidics, the relationship between size, size distribution, shape, architecture, elastic responses and release kinetics can be systematically studied. These understandings are of key importance for the design and fabrication of the next generation polymeric delivery vehicles with custom-made functions for specific applications. In the present work, we engineer the droplet templates generated from microfluidics to fabricate designer polymeric microparticles as delivery vehicles. We investigate and obtain the relationship between the particle size, size distribution, structure of microparticles and their release kinetics. Moreover, we also identify an innovative route to tune the particle shape that enables the investigation of the relationship between particle shape and release kinetics. We take advantage of the dewetting phenomena driving by interfacial tensions of different liquid phases to vary the droplet shape. We find that the phase-separation-induced shape variation of polymeric composite particles can be engineered by manipulating the kinetic barriers during droplet shape evolution. To predict the performance of our advanced polymer particles in practical applications, for instance, in narrow blood vessels in vivo, we also develop a novel capillary micromechanics technique to characterize the linear and non-linear elastic response of our polymer particles on single particle level. The knowledge of the mechanical properties enables the prediction as well as the design of the mechanical aspects of polymer particles in different applications. The ability to control and design the physical, chemical, mechanical properties of the delivery vehicles, and the understanding between these properties and the biological functionalities of delivery vehicles, such as the release kinetics, lead towards tailor-designed delivery vehicles with finely-designed functionalities for various biomedical applications. Our proposed electro-microfluidic platform potentially enables generation of submicron droplet templates with a narrow size distribution and nanoscaled delivery vehicles with well-controlled properties, leading to a next generation of intracellular delivery vehicles. Microfluidic-based technique has the potential to be scaled up by parallel operation. Therefore, we are well-equipped for the massive production of custom-made droplet templates of both micron-size and nanosized, and we can design the physiochemical properties and biological functionalities of the delivery vehicles. These abilities enable us to provide solutions for applications and fundamental topics where encapsulation, preservation and transportation of active ingredients are needed.
published_or_final_version
Mechanical Engineering
Doctoral
Doctor of Philosophy
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5

PIGNATELLI, CATALDO. "Fabrication of biomedical devices through electro-fluid-dynamic-based techniques." Doctoral thesis, Università degli studi di Genova, 2018. http://hdl.handle.net/11567/929355.

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Mukerjee, Erik Vivek. "Design, fabrication and testing of silicon microneedle-based microfabricated biomedical devices /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.

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Ferrell, Nicholas Jay. "Polymer Microelectromechanical Systems: Fabrication and Applications in Biology and Biological Force Measurements." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1204824627.

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Leon, Errol Heradio. "Design and Fabrication Techniques of Devices for Embedded Power Active Contact Lens." DigitalCommons@CalPoly, 2015. https://digitalcommons.calpoly.edu/theses/1387.

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This thesis designed and fabricated various devices that were interfaced to an IC for an active contact lens that notifies the user of an event by detection of an external wireless signal. The contact lens consisted of an embedded antenna providing communication with a 2.4GHz system, as well as inductive charging at an operating frequency of 13.56 MHz. The lens utilized a CBC005 5µAh thin film battery by Cymbet and a manufactured graphene super capacitor as a power source. The custom integrated circuit (IC) was designed using the On Semiconductor CMOS C5 0.6 µm process to manage the battery and drive the display. A transparent, flexible, single cell display was developed utilizing electrochromic ink to indicate to the user of an event. Assembly of the components, encapsulation, and molding were implemented to create the final product. The material properties of the chosen substrate were analyzed for their clearness, flexibility, and biocompatibility to determine its suitability as a contact lens material. Finally, the two different fabrication techniques (microfabrication and screen printing) that were employed to make the devices are compared to determine the favorable process for each part of the system.
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Vasudev, Abhay. "Electrochemical Immunosensing of Cortisol in an Automated Microfluidic System Towards Point-of-Care Applications." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/956.

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This dissertation describes the development of a label-free, electrochemical immunosensing platform integrated into a low-cost microfluidic system for the sensitive, selective and accurate detection of cortisol, a steroid hormone co-related with many physiological disorders. Abnormal levels of cortisol is indicative of conditions such as Cushing’s syndrome, Addison’s disease, adrenal insufficiencies and more recently post-traumatic stress disorder (PTSD). Electrochemical detection of immuno-complex formation is utilized for the sensitive detection of Cortisol using Anti-Cortisol antibodies immobilized on sensing electrodes. Electrochemical detection techniques such as cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) have been utilized for the characterization and sensing of the label-free detection of Cortisol. The utilization of nanomaterial’s as the immobilizing matrix for Anti-cortisol antibodies that leads to improved sensor response has been explored. A hybrid nano-composite of Polyanaline-Ag/AgO film has been fabricated onto Au substrate using electrophoretic deposition for the preparation of electrochemical immunosening of cortisol. Using a conventional 3-electrode electrochemical cell, a linear sensing range of 1pM to 1µM at a sensitivity of 66µA/M and detection limit of 0.64pg/mL has been demonstrated for detection of cortisol. Alternately, a self-assembled monolayer (SAM) of dithiobis(succinimidylpropionte) (DTSP) has been fabricated for the modification of sensing electrode to immobilize with Anti-Cortisol antibodies. To increase the sensitivity at lower detection limit and to develop a point-of-care sensing platform, the DTSP-SAM has been fabricated on micromachined interdigitated microelectrodes (µIDE). Detection of cortisol is demonstrated at a sensitivity of 20.7µA/M and detection limit of 10pg/mL for a linear sensing range of 10pM to 200nM using the µIDE’s. A simple, low-cost microfluidic system is designed using low-temperature co-fired ceramics (LTCC) technology for the integration of the electrochemical cortisol immunosensor and automation of the immunoassay. For the first time, the non-specific adsorption of analyte on LTCC has been characterized for microfluidic applications. The design, fabrication technique and fluidic characterization of the immunoassay are presented. The DTSP-SAM based electrochemical immunosensor on µIDE is integrated into the LTCC microfluidic system and cortisol detection is achieved in the microfluidic system in a fully automated assay. The fully automated microfluidic immunosensor hold great promise for accurate, sensitive detection of cortisol in point-of-care applications.
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Battistelli, Elisa. "Microfluidic microbial fuel cell fabrication and rapid screening of electrochemically microbes." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7301/.

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The demand for novel renewable energy sources, together with the new findings on bacterial electron transport mechanisms and the progress in microbial fuel cell design, have raised a noticeable interest in microbial power generation. Microbial fuel cell (MFC) is an electrochemical device that converts organic substrates into electricity via catalytic conversion by microorganism. It has represented a continuously growing research field during the past few years. The great advantage of this device is the direct conversion of the substrate into electricity and in the future, MFC may be linked to municipal waste streams or sources of agricultural and animal waste, providing a sustainable system for waste treatment and energy production. However, these novel green technologies have not yet been used for practical applications due to their low power outputs and challenges associated with scale-up, so in-depth studies are highly necessary to significantly improve and optimize the device working conditions. For the time being, the micro-scale MFCs show great potential in the rapid screening of electrochemically active microbes. This thesis presents how it will be possible to optimize the properties and design of the micro-size microbial fuel cell for maximum efficiency by understanding the MFC system. So it will involve designing, building and testing a miniature microbial fuel cell using a new species of microorganisms that promises high efficiency and long lifetime. The new device offer unique advantages of fast start-up, high sensitivity and superior microfluidic control over the measured microenvironment, which makes them good candidates for rapid screening of electrode materials, bacterial strains and growth media. It will be made in the Centre of Hybrid Biodevices (Faculty of Physical Sciences and Engineering, University of Southampton) from polymer materials like PDMS. The eventual aim is to develop a system with the optimum combination of microorganism, ion exchange membrane and growth medium. After fabricating the cell, different bacteria and plankton species will be grown in the device and the microbial fuel cell characterized for open circuit voltage and power. It will also use photo-sensitive organisms and characterize the power produced by the device in response to optical illumination.
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Книги з теми "Biomedical Device Fabrication"

1

Ito, Yoshihiro. Photochemistry for Biomedical Applications: From Device Fabrication to Diagnosis and Therapy. Springer, 2018.

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Ito, Yoshihiro. Photochemistry for Biomedical Applications: From Device Fabrication to Diagnosis and Therapy. Springer, 2018.

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3

Photochemistry for Biomedical Applications: From Device Fabrication to Diagnosis and Therapy. Springer, 2018.

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4

Alarcon, Emilio I., May Griffith, and Klas I. Udekwu. Silver Nanoparticle Applications: In the Fabrication and Design of Medical and Biosensing Devices. Springer, 2016.

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5

Alarcon, Emilio I., May Griffith, and Klas I. Udekwu. Silver Nanoparticle Applications: In the Fabrication and Design of Medical and Biosensing Devices. Springer, 2015.

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6

Alarcon, Emilio I., May Griffith, and Klas I. Udekwu. Silver Nanoparticle Applications: In the Fabrication and Design of Medical and Biosensing Devices. Springer International Publishing AG, 2015.

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7

Fukuda, Toshio, Masahiro Nakajima, Masaru Takeuchi, and Yasuhisa Hasegawa. Micro- and nanotechnology for living machines. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780199674923.003.0052.

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The chapter Micro- and nanotechnology for living machines describes research on new biohybrid technologies, engineered at the micro- and nano-scales, that combine some of the benefits of mechanical and electronic systems with those of biological systems. The chapter begins by reviewing some of the challenges of building devices at very small physical scales and discusses how new fabrication methodologies could impact on different classes of industrial, daily life, and biomedical products. We next explain how progress is being achieved through advances in micro- and nanomechatronics, particularly in the field of nanorobotic manipulation. Finally, we summarize recent progress towards building biohybrid living machines that combine nanomaterials with biological cells and outline the design of a micro- and nanorobotic manipulation system for cell assembly called the nanolaboratory.
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8

Porous Silicon: Biomedical and Sensor Applications. Taylor & Francis Group, 2015.

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9

Optical MEMS for Chemical Analysis and Biomedicine. Institution of Engineering & Technology, 2016.

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Optical MEMS for Chemical Analysis and Biomedicine. Institution of Engineering & Technology, 2016.

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Частини книг з теми "Biomedical Device Fabrication"

1

Srivastava, Rohit, and Jayeeta Chattopadhyay. "Design and Fabrication of Nanomaterial-Based Device for Pressure Sensorial Applications." In Advanced Nanomaterials in Biomedical, Sensor and Energy Applications, 1–14. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-5346-7_1.

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2

Mohmad, Salina bt, C. F. Chau, T. Melvin, S. Atri, and C. Kaminski. "Nano-porous Polysilicon Fabrication for Micro Electro Mechanical System (MEMS) Drug Delivery Device." In 3rd Kuala Lumpur International Conference on Biomedical Engineering 2006, 329–33. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-68017-8_84.

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3

Salih, N. M., M. Z. Sahdan, M. Morsin, and M. T. Asmah. "Fabrication and Integration of PDMS-Glass Based Microfluidic with Optical Absorbance Measurement Device for Coliform Bacteria Detection." In 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6), 75–81. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4361-1_13.

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Lascano, Sheila, and Danilo Estay. "Biomedical Devices: Materials, Fabrication and Control." In Intelligent Systems, Control and Automation: Science and Engineering, 195–219. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-319-40003-7_9.

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Sarma, Upasana, Pranjal Chandra, and Shrikrishna N. Joshi. "Advanced Microchannel Fabrication Technologies for Biomedical Devices." In Advanced Micro- and Nano-manufacturing Technologies, 127–43. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-3645-5_6.

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Huber, T. E., S. Johnson, K. A. Shirvani, Q. Barclif, T. Brower, A. Nikolaeva, and L. Konopko. "Fabrication of Bismuth Telluride Wire Thermoelectric Devices." In 3rd International Conference on Nanotechnologies and Biomedical Engineering, 97–100. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-287-736-9_23.

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7

Horiuchi, Toshiyuki, Shinpei Yoshino, and Jyo Miyanishi. "Simple Fabrication Method of Micro-Fluidic Devices with Thick Resist Flow Paths Designed Arbitrarily Using Versatile Computer Aided Design Tools." In Biomedical Engineering Systems and Technologies, 19–33. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-26129-4_2.

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8

Padha, B. "Fabrication Approaches for Piezoelectric Materials." In Materials Research Foundations, 37–60. Materials Research Forum LLC, 2022. http://dx.doi.org/10.21741/9781644902097-2.

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After decades of study and development, piezoelectric materials have been used in various applications. Piezoelectric material is highly acknowledged as one of the primary functional materials in precision and acoustic engineering fields. Researchers are being pushed to explore novel materials and device combinations for new applications due to increasing demand, notably from the electrical, energy, and biomedical sectors. On the other hand, engineers are always working to enhance existing technology. Since the field has such a broad reach, it is vital to present an overview of the many areas of piezoelectric materials. This chapter focuses on the fabrication of different piezoelectric materials, applications, and challenges.
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9

Padha, B. "Fabrication Approaches for Piezoelectric Materials." In Materials Research Foundations, 37–60. Materials Research Forum LLC, 2022. http://dx.doi.org/10.21741/9781644902073-2.

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After decades of study and development, piezoelectric materials have been used in various applications. Piezoelectric material is highly acknowledged as one of the primary functional materials in precision and acoustic engineering fields. Researchers are being pushed to explore novel materials and device combinations for new applications due to increasing demand, notably from the electrical, energy, and biomedical sectors. On the other hand, engineers are always working to enhance existing technology. Since the field has such a broad reach, it is vital to present an overview of the many areas of piezoelectric materials. This chapter focuses on the fabrication of different piezoelectric materials, applications, and challenges.
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10

Bag, Monojit, Jitendra Kumar, and Ramesh Kumar. "Graphene-based Nanocomposites for Electro-optic Devices." In Current and Future Developments in Nanomaterials and Carbon Nanotubes, 190–204. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815050714122030014.

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Graphene, the most exciting carbon allotrope, and its derivatives such as graphene oxide and graphene quantum dots have sparked a flurry of research and innovation owing to their unprecedented optoelectronic properties. Graphene and its nanocomposites have been widely used in a variety of opto-electronic devices such as photodetectors, transistors, actuators, biomedical aids, and membranes. Their sp2 hybridization state provides some extraordinary opto-electronic and mechanical properties. Chemical exfoliation of graphite into graphene and graphene oxide allows us to mix graphene nanocomposites into various layers of organic solar cells and other organic semiconductor-based optoelectronic devices, especially for roll-to-roll fabrication of large-area devices at a lower cost. Recently, these nanocomposites have also been utilized as charge transport layers and surface modifiers in perovskite solar cells and perovskite light-emitting diodes. Researchers have found that the presence of graphene, even at very low loading, can significantly improve the device's performance. In this chapter, we have discussed the application of graphene oxide, reduced graphene oxide, and doped graphene oxide in various combinations in perovskite solar cells and perovskite light-emitting diodes; these nanomaterials can be utilized either in transport layers of a multilayered device or directly incorporated in the active layers of these optoelectronic devices. These nanocomposites generally improve the device efficiencies by improving the band alignment at heterojunctions in a multilayered device by substantially reducing the trap states and the charge transfer resistance. These nanocomposites are found to achieve significantly improved device power conversion efficiency and stability of perovskite-based optoelectronic devices.
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Тези доповідей конференцій з теми "Biomedical Device Fabrication"

1

Kumar, G. Naga Siva, Sushanta K. Mitra, and V. Ramgopal Rao. "Fabrication of Dielectrophoretic Microfluidic Device." In ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2009. http://dx.doi.org/10.1115/icnmm2009-82170.

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Technological needs of the recent times require the improvement in micro-scale devices that manipulate the bioparticles like cells, bacteria, viruses, DNA, proteins, etc. Such devices have diverse and widespread applications in biomedical, drug delivery and diagnostics for separating, trapping, sorting and mixing of particles. Dielectrophoresis (DEP) is one of the techniques used for manipulating the particles in a nonuniform electric field. In the present study, fabrication and characterization of microfluidic device for DEP is analyzed and experimented. An overview of fabrication techniques which can be used for making of DEP device is provided with experimental details. DEP microfluidic device is fabricated by preparing channels and microelectrodes on PDMS and glass materials respectively. Oxygen plasma treatment has been used for bonding the PDMS channel and micro-electrode patterned glass substrate. Further experiments are conducted to demonstrate the DEP principle with polystyrene microbeads. The movement of microbeads towards the high electric field strengths at 12Vpp and 10 MHz frequency is observed. Characterizing equipments like ellipsometer, profilometer, scanning electron microscopy, contact angle measurement systems were used for measuring oxide layer thickness, width and depth of the channels, surface characteristics etc., during fabrication.
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2

Choi, Jeongkeun, Bumkyoo Choi, and Hoyoung Lee. "Fabrication and experiment of the hemodialysis unit device." In 2013 6th Biomedical Engineering International Conference (BMEiCON). IEEE, 2013. http://dx.doi.org/10.1109/bmeicon.2013.6687647.

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3

Salehipour, Saeed, Nabiollah Abolfathi, and Ataallah Hashemi. "Design and fabrication of cell adhesion measuring device." In 2014 21th Iranian Conference on Biomedical Engineering (ICBME). IEEE, 2014. http://dx.doi.org/10.1109/icbme.2014.7043943.

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Heller, Michael J., Dieter Dehlinger, Sadik Esener, and Benjamin Sullivan. "Electric Field Directed Fabrication of Biosensor Devices From Biomolecule Derivatized Nanoparticles." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38093.

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An electronic microarray has been used to carry out directed self-assembly of higher order 3D structures from Biotin/Streptavidin and DNA derivatized nanoparticles. Structures with more than forty layers of alternating biotin and streptavidin and DNA nanoparticles were fabricated using a 400 site CMOS microarray system. In this process, reconfigurable electric fields produced by the microarray device have been used to rapidly transport, concentrate and accelerate the binding of 40 and 200 nanometer biotin, streptavidin, DNA and peroxidase derivatized nanoparticles to selected sites on the microarray. The nanoparticle layering process takes less than one minute per layer (10–20 seconds for addressing and binding nanoparticles, 40 seconds for washing). The nanoparticle addressing/binding process can be monitored by changes in fluorescence intensity as each nanoparticle layer is deposited. The final multilayered 3-D structures are about two microns in thickness and 50 microns in diameter. Work is now focused on assembling “micron size” biosensor devices from bio-molecule derivatized luminescent and fluorescent nanoparticles. The proposed structure for a nanolayered glucose sensor device includes a base layer of biotin/streptavidin nanoparticles, a layer of glucose oxidase derivatized nanoparticles, a layer of peroxidase derivatized nanoparticles, a layer of quantum dots, and a final layer of biotin/streptavidin nanoparticles. Such a device will serve as a prototype for a wide variety of applications which includes other biosensor devices, lab-on a-chip devices, in-vivo drug delivery systems and “micron size” dispersible bio/chem sensors for environmental, military and homeland security applications.
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5

Yan, Karen Chang, John Sperduto, Michael Rossini, and Michael Sebok. "Multi-Layer Construction Process for Fabricating Electrospun Fiber Embedded Microfluidic Devices." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-52086.

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Microfluidic devices are widely used in biomedical applications owing to their inherent advantages. Microfabrication techniques are common methods for fabricating microfluidic devices, which require specialized equipment. This paper presents a multi-layer construction process for producing microfluidic devices via integrating two accessible fabrication techniques — hydrogel molding, a microfabrication-free method, and electrospinning (ES). The formed microchannels were examined via analyzing micrographs. Preliminary results demonstrate the feasibility of the method and potential for incorporating complex channels and device optimization.
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Ravi, Prashanth, Panos S. Shiakolas, Jacob C. Oberg, Shahid Faizee, and Ankit K. Batra. "On the Development of a Modular 3D Bioprinter for Research in Biomedical Device Fabrication." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-51555.

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Biomanufacturing research involving solid freeform fabrication techniques has become fairly widespread in recent times. The layer-by-layer building concept provides an opportunity towards the development of a modular 3D printer to broaden the scope of biomanufacturing research. This research discusses the features of a Custom Multi-Modality 3D Bioprinter (CMMB) developed in the MARS lab at the University of Texas at Arlington (http://mars.uta.edu/). The CMMB currently includes a number of printing modules; two Fused Filament Fabrication (FFF), one Photo Polymerization (PP), one Viscous Extrusion (VE) and one Inkjet (IJ). The development of the custom bioprinter and each module are discussed; focusing on the advantages of a modular design, and on the unique features present in each individual module. Select constructs fabricated using individual or a combination of modules are presented and discussed. Design of Experiments (DOE) principles employing statistical software were used to characterize the CMMB; interactions between fabrication process parameters and their effect on deposited strand characteristics were analyzed. These results were employed to improve the quality of subsequently fabricated constructs. Initial experiments and fabricated constructs demonstrate that the custom bioprinter is a novel CAD-CAM biomanufacturing platform for research in methodologies, materials and processes for the fabrication of biomedical devices.
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Moita, A. S., F. Jacinto, and A. L. N. Moreira. "Design, Test and Fabrication of a Droplet based Microfluidic Device for Clinical Diagnostics." In 11th International Conference on Biomedical Electronics and Devices. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0006656600880095.

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8

Komirisetty, Archana, Frances Williams, Aswini Pradhan, and Meric Arslan. "Integrating Sensors With Nanostructures for Biomedical Applications." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93121.

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This paper presents the fabrication of sensors that are integrated with nanostructures and bio-functionalized to create novel devices for biomedical applications. Biosensors are in great demand for various applications including for the agriculture and food industries, environmental monitoring, and medical diagnostics. Much research is being focused on the use of nanostructures (nanowires, nanotubes, nanoparticles, etc.) to provide for miniaturization and improved performance of these devices. The use of nanostructures is favorable for such applications since their sizes are closer to that of biological and chemical species and therefore, improve the signal generated. Moreover, their high surface-to-volume ratio results in devices with very high sensitivity. The use of nanotechnology leads to smaller, lower-power smart devices. Thus, this paper presents the integration of sensors with nanostructures for biomedical applications, specifically, glucose sensing. In the work presented, a glucose biosensor and its fabrication process flow are described. The device is based on electrochemical sensing using a working electrode with bio-functionalized zinc oxide (ZnO) nano-rods. Among all metal oxide nanostructures, ZnO nano-materials play a significant role as a sensing element in biosensors due to their properties such as high isoelectric point (IEP), fast electron transfer, non-toxicity, biocompatibility, and chemical stability which are very crucial parameters to achieve high sensitivity. Amperometric enzyme electrodes based on glucose oxidase (GOx) are used due to their stability and high selectivity to glucose. The device also consists of silicon dioxide and titanium layers as well as platinum working and counter electrodes and a silver/silver chloride reference electrode. The chlorination process on the reference electrode was optimized for various times using field emission scanning electron microscope (FESEM) and energy-dispersive X-ray spectroscopy (EDS or EDX) measurements. The ZnO nanorods were grown using the hydrothermal method and will be bio-functionalized with GOx for electrochemical sensing. Once completed, the sensors will be tested to characterize their performance, including their sensitivity and stability.
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Ren, Jing, and Sriram Sundararajan. "Microfluidic Channel Fabrication With Tailored Wall Roughness." In ASME 2012 International Manufacturing Science and Engineering Conference collocated with the 40th North American Manufacturing Research Conference and in participation with the International Conference on Tribology Materials and Processing. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/msec2012-7328.

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Realistic random roughness of channel surfaces is known to affect the fluid flow behavior in microscale fluidic devices. This has relevance particularly for applications involving non-Newtonian fluids, such as biomedical lab-on-chip devices. In this study, a surface texturing process was developed and integrated into microfluidic channel fabrication. The process combines colloidal masking and Reactive Ion Etching (RIE) for generating random surfaces with desired roughness parameters on the micro/nanoscale. The surface texturing process was shown to be able to tailor the random surface roughness on quartz. A Large range of particle coverage (around 6% to 67%) was achieved using dip coating and drop casting methods using a polystyrene colloidal solution. A relation between the amplitude roughness, autocorrelation length, etch depth and particle coverage of the processed surface was built. Experimental results agreed reasonably well with model predictions. The processed substrate was further incorporated into microchannel fabrication. Final device with designed wall roughness was tested and proved a satisfying sealing performance.
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10

Dawoud, Abdulilah A. "Fabrication of Fully Integrated Microfluidic Device With Carbon Sensing Electrode for the Detection of Forensic and Biomedical Targets." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-41454.

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Fabrication of fully integrated capillary electrophoresis (CE)-based microfluidic device with integrated carbon sensing electrode is described in this paper. A combination of microfabrication protocols were employed for fabricating the hybrid PDMS/glass microfluidic device including chemical wet etching, soft lithography, and micromolding techniques. The microdevice is comprised of glass substrate with integrated gold electrodes and carbon sensing electrode, and polydimethyl siloxane (PDMS) slab that encompasses the microchannels network. The carbon sensing electrode was physically characterized via atomic force microscopy (AFM) and Raman spectrometry. In addition, its quality was evaluated electrochemically and compared to commercial glassy carbon electrodes upon performing cyclic voltammetric analysis of two illicit drugs, morphine and codeine. The analytical performance of the stand-alone microdevice was evaluated upon testing the injection, separation and amperometric detection on the carbon sensing electrode. The carbon sensing electrode provides stable background current during applying high sensing potential, which is of particular necessity for sensing molecules that can be only detected at high potentials including morphine and codeine.
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