Дисертації з теми "Biological psychology not elsewhere classified"
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McLarnon-Riches, Christian James. "The use of lipid profiles from immobilised Selenastrum capricornutum in the biological surveillance of freshwaters." Thesis, University of Central Lancashire, 2000. http://clok.uclan.ac.uk/19764/.
Повний текст джерелаLu, Chen. "Expression profile of multidrug resistance genes and proteins in cancerous and stem cells." Thesis, University of Central Lancashire, 2008. http://clok.uclan.ac.uk/19754/.
Повний текст джерелаWoodruff, Kim Therese. "The effects of anaesthetic agents on synapses of lymnaea stagnalis (L.)." Thesis, University of Central Lancashire, 2004. http://clok.uclan.ac.uk/20248/.
Повний текст джерелаChandranath, Swaminathan Irwin. "Comparitive activities and mechanisms of action of three novel antiulcer agents." Thesis, University of Central Lancashire, 2000. http://clok.uclan.ac.uk/21028/.
Повний текст джерелаHigginson, James Matthew. "Signal transduction pathways involved in skeletal muscle fibre type regulation." Thesis, University of Central Lancashire, 2003. http://clok.uclan.ac.uk/21870/.
Повний текст джерелаPool, Ursula. "The impact of water and anthropogenic objects on implicit evaluations of natural scenes : a restorative environments perspective." Thesis, University of Central Lancashire, 2017. http://clok.uclan.ac.uk/17669/.
Повний текст джерела(10711986), Michelle E. Coverdale. "The Effect of Choice on Memory and Value for Consumer Products." Thesis, 2021.
Знайти повний текст джерела(6622427), Zhe Sun. "APPLICATION OF PHOTOCHEMICAL AND BIOLOGICAL APPROACHES FOR COST-EFFECTIVE ALGAL BIOFUEL." Thesis, 2019.
Знайти повний текст джерелаRapid growth of energy consumption and greenhouse gas emissions from fossil fuels have promoted extensive research on biofuels. Algal biofuels have been considered as a promising and environmentally friendly renewable energy source. However, several limitations have inhibited the development of cost-effective biofuel production, which includes unstable cultivation caused by invading organisms and high cost of lipid extraction. This dissertation aims to investigate photochemical approaches to prevent culture collapse caused by invading organisms and biological approaches for the development of cost-effective lipid extraction methods.
As a chemical-free water treatment technology, ultraviolet (UV) irradiation has been widely applied to inactivate pathogens but has not been used in algal cultivation to control invading organisms. To evaluate the potential of using UV irradiation to control invading algal species and minimize virus predation, Tetraselmis sp. and Paramecium bursaria Chlorella virus 1 (PBCV-1) were examined as challenge organisms to evaluate effectiveness of UV disinfection. The concentration of viable (reproductively/infectively active) cells and viruses were quantified by a most probable number (MPN) assay and a plaque assay. A low-pressure collimated-beam reactor was used to investigate UV254 dose-response behavior of both challenge organisms. A medium-pressure collimated-beam reactor equipped with a series of narrow bandpass optical filters was used to investigate the action spectra of both challenge organisms. Both challenge organisms showed roughly five log10 units of inactivation for UV254 doses over 120 mJ/cm2. the most effective wavelengths for inactivation of Tetraselmis were from 254 nm to 280 nm, in which the inactivation was mainly attributed to UV-induced DNA damage. On the contrary, the most effective wavelength for inactivation of PBCV-1 was observed at 214 nm, where the loss of infectivity was mainly attributed to protein damage. These results provide important information for design of UV reactors to minimize the impact of invading organisms in algal cultivation systems.
Additionally, a virus-assisted cell disruption method was developed for cost-effective lipid extraction from algal biomass. Detailed mechanistic studies were conducted to evaluate infection behavior of Chlorovirus PBCV-1 on Chlorella sp., impact of infection on mechanical strength of algal cell wall, lipid yield, and lipid distribution. Viral disruption with multiplicity of infection (MOI) of 10-8 completely disrupted concentrated algal biomass in six days. Viral disruption significantly reduced the mechanical strength of algal cells for lipid extraction. Lipid yield with viral disruption increased more than three times compared with no disruption control and was similar to that of ultrasonic disruption. Moreover, lipid composition analysis showed that the quality of extracted lipids was not affected by viral infection. The results showed that viral infection is a cost-effective process for lipid extraction from algal cells as extensive energy input and chemicals required by existing disruption methods are no longer needed.
Overall, this dissertation provides innovative approaches for the development of cost-efficient algal biofuels. Application of UV disinfection and viral disruption significantly reduces chemical consumption and improves sustainability of algal biofuel production.
(11186220), Julianna Gesun. "Beyond Surviving: Developing and Testing a Model of Thriving for Engineering Students." Thesis, 2021.
Знайти повний текст джерела(6594272), Katherine E. Adams. "Implicit Gratitude Theories." Thesis, 2019.
Знайти повний текст джерела(8815928), Samantha Jurecki. "APPLICATION AND VALIDATION OF THE EDNA-METABARCODED MIFISH/MITOFISH PIPELINE FOR ASSESSMENT OF NATIVE AND NON-NATIVE FISH COMMUNITIES OF LAKE MICHIGAN." Thesis, 2020.
Знайти повний текст джерела(9757040), Lina M. Aboulmouna. "Towards cybernetic modeling of biological processes in mammalian systems—lipid metabolism in the murine macrophage." Thesis, 2020.
Знайти повний текст джерелаRegulation of metabolism in mammalian cells is achieved through a complex interplay between cellular signaling, metabolic reactions, and transcriptional changes. The modeling of metabolic fluxes in a cell requires the knowledge of all these mechanisms, some of which may be unknown. A cybernetic approach provides a framework to model these complex interactions through the implicit accounting of such regulatory mechanisms, assuming a biological “goal”. The goal-oriented control policies of cybernetic models have been used to predict metabolic phenomena ranging from complex substrate uptake patterns and dynamic metabolic flux distributions to the behavior of gene knockout strains. The premise underlying the cybernetic framework is that the regulatory processes affecting metabolism can be mathematically formulated as a cybernetic objective through variables that constrain the network to achieve a specified biological “goal”.
Cybernetic theory builds on the perspective that regulation is organized towards achieving goals relevant to an organism’s survival or displaying a specific phenotype in response to a stimulus. While cybernetic models have been established by prior work carried out in bacterial systems, we show its applicability to more complex biological systems with a predefined goal. We have modeled eicosanoid, a well-characterized set of inflammatory lipids derived from arachidonic acid, metabolism in mouse bone marrow derived macrophage (BMDM) cells stimulated by Kdo2-Lipid A (KLA, a chemical analogue of Lipopolysaccharide found on the surface of bacterial cells) and adenosine triphosphate (ATP, a danger signal released in response to surrounding cell death) using cybernetic control variables. Here, the cybernetic goal is inflammation; the hallmark of inflammation is the expression of cytokines which act as autocrine signals to stimulate a pro-inflammatory response. Tumor necrosis factor (TNF)-α is an exemplary pro-inflammatory marker and can be designated as a cybernetic objective for modeling eicosanoid—prostaglandin (PG) and leukotriene (LK)—metabolism. Transcriptomic and lipidomic data for eicosanoid biosynthesis and conversion were obtained from the LIPID Maps database. We show that the cybernetic model captures the complex regulation of PG metabolism and provides a reliable description of PG formation using the treatment ATP stimulation. We then validated our model by predicting an independent data set, the PG response of KLA primed ATP stimulated BMDM cells.
The process of inflammation is mediated by the production of multiple cytokines, chemokines, and lipid mediators each of which contribute to specific individual objectives. For such complex processes in mammalian systems, a cybernetic objective based on a single protein/component may not be sufficient to capture all the biological processes thereby necessitating the use of multiple objectives. The choice of the objective function has been made by intuitive considerations in this thesis. If objectives are conjectured, an argument can be made for numerous alternatives. Since regulatory effects are estimated from unregulated kinetics, one encounters the risk of multiplicity in this regard giving rise to multiple models. The best model is of course that which is able to predict a comprehensive set of perturbations. Here, we have extended our above model to also capture the dynamics of LKs. We have used migration as a biological goal for LK using the chemoattractant CCL2 as a key representative molecule describing cell activation leading to an inflammatory response where a goal composed of multiple cybernetic objectives is warranted. Alternative model objectives included relating both branches of the eicosanoid metabolic network to the inflammatory cytokine TNF-α, as well as the simple maximization of all metabolic products such that each equally contributes to the inflammatory system outcome. We were again able to show that all three cybernetic objectives describing the LK and PG branches for eicosanoid metabolism capture the complex regulation and provide a reliable description of eicosanoid formation. We performed simulated drug and gene perturbation analyses on the system to identify differences between the models and propose additional experiments to select the best cybernetic model.
The advantage to using cybernetic modeling is in its ability to capture system behavior without the same level of detail required for these interactions as standard kinetic modeling. Given the complexity of mammalian systems, the cybernetic goal for mammalian cells may not be based solely on survival or growth but on specific context dependent cellular responses. In this thesis, we have laid the groundwork for the application of cybernetic modeling in complex mammalian systems through a specific example case of eicosanoid metabolism in BMDM cells, illustrated the case for multiple objectives, and highlighted the extensibility of the cybernetic framework to other complex biological systems.
(5931173), Jessica Merkling. "Development of an Environmental DNA Assay for Eastern Massasauga." Thesis, 2019.
Знайти повний текст джерела(8102609), Kara A. Negrini. "Novel Extrinsic and Intrinsic Factors Mediating Osteoarthritis." Thesis, 2020.
Знайти повний текст джерелаOsteoarthritis (OA) is a leading cause of disability globally, with higher incidence in older people and lower socioeconomic status populations. The challenges health care systems face with management of the disease highlights the importance of OA research. Many studies examine possible risk factors of knee and hip OA including obesity, smoking, and alcohol consumption. Findings support that while obesity increases risk of knee OA, smoking is not a major risk factor. These extrinsic factors are, however, associated with lower socioeconomic status, and also with anxiety and depression disorders. Up to 30% of patients with chronic knee OA have described psychological stress and decreased quality of life due to debilitating pain, but the effects of psychological stress on development of knee OA has not been described.
At the cellular level, mechanosensitive cation channels in cartilage and bone, are involved with OA, but studies looking specifically at synovium and joint capsule are limited. Transient receptor potential (TRP) channels are upregulated in joint capsule in end-stage primary shoulder OA. We were unable to identify any previous studies evaluating Piezo channel expression in musculoskeletal soft tissues, but Piezo channel antagonism reduces chondrocyte death after mechanical injury. These findings suggest channels may help regulate joint responses to repetitive loading during training or work while also contributing to protective mechanisms within the musculoskeletal system. The overall objective of this research was to investigate factors that impact OA development or the disease phenotype. Two studies evaluated the following aims: 1) demonstrate the influence of chronic psychological stress on knee OA and overall systemic health, and 2) characterize the role of mechanosensitive channels in the joint capsule in OA. The first study used a mouse chronic social defeat model paired with destabilization of the medial meniscus (DMM) surgery to create a social stress scenario during OA development. We hypothesized chronic social defeat would exacerbate knee OA structural changes and systemic inflammation. The second study aimed to explore the role of mechanosensitive channels in joint capsule during OA development in the equine. Immunohistochemistry was performed on forelimb fetlock joint capsule from horses with varying degrees of lameness to first identify TRP and Piezo channel expression. Next, fibroblasts were isolated from the tissue to determine channel activity. We hypothesized that TRP and Piezo channels are required for normal homeostasis, but are dysregulated in OA and dysregulation contributes to fibrosis of the joint capsule. Joint capsule fibrosis leads to joint stiffening and reduced range of motion, two of the cardinal signs of OA.
The results of the first study showed OA was induced to a similar extent in both groups of mice that underwent DMM surgery. While anxiety- and depressive-like behaviors were exhibited by mice that underwent chronic social defeat episodes, unexpectedly, the majority of systemic inflammatory markers were not worse in mice with DMM and chronic social defeat compared to DMM alone. We were also able to show TRP and Piezo channel expression in one normal dorsal and palmar fetlock joint capsule sample, however, COVID-19 prevented further investigation. With our results we were able to conclude that while chronic social stress influences development of OA, in the current experiments, neither systemic inflammation nor structural signs of knee OA were worse with chronic social stress. We hope that exploration of OA through these two studies will help us understand how the disease contributes to overall systemic dysfunction while also providing a baseline for future development of TRP and Piezo channel modulators to prevent joint pathologies.
(6867047), Robert Michael Binkley. "BI-VARIATE GROWTH MODEL OF PICHIA PASTORIS INCLUDING OXYGEN CONSIDERATIONS AND ITS IMPORTANCE IN RECOMBINANT PROTEIN PRODUCTION." Thesis, 2019.
Знайти повний текст джерелаThe methylotrophic yeast, Pichia pastoris (recently reclassified as spp. Komagatella) has long been regarded as a useful host organism for the production of recombinant proteins, particularly when using the AOX system which utilizes methanol as both the inducing agent as well as the primary carbon source for growth and energy. Significant historical work has shown that growth rate and protein productivity can be correlated to methanol concentration. However, the relationship between oxygen and protein productivity are less consistent. While with many variations models having been developed and used for analyzing culture kinetics, these models have only been applied to methanol concentration. Furthermore, while results for methanol are fairly consistent, oxygen considerations have been far less consistent.
This work presents various bi-variate models which includes considerations for growth and inhibition for both methanol and oxygen with this expanded model showing strong alignment to previous works to both oxygen and methanol data. While more work is necessary to fully confirm and validate which form of the bivariate model is most appropriate, this work provides a framework necessary to expand analysis to include oxygen considerations. This framework has the potential to be used to further inform selection of feeding methodology as well as direct investigations into metabolic studies.
Absolon, Victor. "A comparison of biological and chemically induced leaching mechanisms of chalcopyrite." 2008. http://arrow.unisa.edu.au:8081/1959.8/48668.
Повний текст джерелаThesis (PhD)--University of South Australia, 2008.
(6859052), Jacqueline N. Williams. "DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF POTENT HIV-1 PROTEASE INHIBITORS WITH NOVEL BICYCLIC OXAZOLIDINONE AND BIS SQUARAMIDE SCAFFOLDS." Thesis, 2019.
Знайти повний текст джерелаIn 2018, the World Health Organization (WHO) reported approximately 37 million people are living with the Human Immunodeficiency Virus (HIV). Suppressing replication of the virus down to undetectable levels was achieved by combination antiretroviral therapy (cART) which effectively reduced the mortality and morbidity rates of HIV positive individuals. Despite the improvements towards combatting HIV/AIDS, no successful treatment exists to eradicate the virus from an infected individual. Treatment regimens are lifelong and prompt less than desirable side effects including but not limited to; drug-drug interactions, toxicity, systemic organ complications, central nervous system HIV triggered disorders and most importantly, drug resistance. Current therapies are becoming ineffective against highly resistant HIV strains making the ability to treat long-term viral suppression a growing issue. Therefore, potent and more effective HIV inhibitors provide the best chance for long-term successful cART.
HIV-1 protease (PR) enzyme plays a critical role in the life cycle and replication of HIV. Significant advancements were achieved through structure-based design and X-ray crystallographic analysis of protease-bound to HIV-1 and brought about several FDA protease inhibitors (PI). Highly mutated HIV-1 variants create a challenge for current and future treatment regimens. This thesis work focuses on the design, synthesis, and evaluation of two new classes of potent HIV-1 PIs that exhibit a novel bicyclic oxazolidinone feature as the P2 ligand and a novel bis squaramide scaffold as the P2/P3 ligand. Several inhibitors displayed good to excellent activity toward HIV-1 protease and significant antiviral activity in MT-4 cells. Inhibitors 1.65g and 1.65h were further evaluated against a panel of highly resistant multidrug-resistant HIV-1 variants and displayed antiviral activity similar to Darunavir. X-ray crystal structures of inhibitor 1.65a and inhibitor 1.65i were co-crystallized with wild type HIV-1 protease and solved at a 1.22 Å and 1.30 Å resolution and maintained strong hydrogen bond with the backbone of the PR enzyme.
(5929754), Sydney E. Hollingshead. "Biological Applications of Elastin- and Mussel-Inspired Polymers." Thesis, 2019.
Знайти повний текст джерела(9182093), Elizabeth A. Wiemers. "TITRATING COGNITIVE CONTROL: TRIAL-LEVEL DYNAMIC USE OF PROACTIVE AND REACTIVE COGNITIVE CONTROL." Thesis, 2020.
Знайти повний текст джерелаCognitive control is accomplished by a set of higher-order cognitive processes that are recruited to aid in the completion of various tasks. A popular proposed mechanism is the Dual Mechanisms of Control (Braver, Gray, & Burgess, 2007), proposing proactive and reactive mechanisms. While neuroscience studies provide evidence that these are two distinct processes, it remains unclear whether the processes are competing, or whether they can be used together. That is, are the two processes able to both be enacted to some degree? Further, whether these mechanisms can be titrated to produce a gradient-like use of control on a trial-level basis is unknown. These are the two primary pursuits of this dissertation. Experiment 1 shows the titrated pattern of control use, indicating (a) sensitivity to task demands, and (b) dynamic use of proactive and reactive control at the trial level, in a new task. Further, a novel contribution is the observation of ability to titrate the use of control. Additional experiments relate performance on this task to working memory (Experiment 2), replicate the findings in an online format (Experiment 3), and differentiate performance from distance effects commonly seen in relative judgment tasks (Experiment 4). This work has implications for the understanding of how cognitive control functions and how dynamically the use of these mechanisms can be adjusted.
(9183593), Noah S. Feldman. "Does environmental variability explain male parental care in a burying beetle?" Thesis, 2020.
Знайти повний текст джерела(6996329), Garrett M. O'Day. "Improving Problem Solving with Retrieval-Based Learning." Thesis, 2019.
Знайти повний текст джерелаRecent research asserts that the mnemonic benefits gained from retrieval-based learning vanish for complex materials. Subsequently, it is recommended that students study worked examples when learning about complex, problem-centered tasks. The experiments that have evaluated the effectiveness of studying worked examples tend to overlook the mental processing that students engage in when completing retrieval-based learning activities. In contrast, theories of transfer-appropriate processing emphasize the importance of compatibility between the cognitive processing required by the test and the cognitive processing that is activated during learning. For learners to achieve optimal test performance, according to transfer-appropriate processing, they need to study in such a way that they are engaging in the same mental processing that will be required of them when tested. This idea was used to generate testable predictions that compete against the claim that the retrieval practice effect disappears for complex materials, and these competing predictions were evaluated in three experiments that required students to learn about the Poisson probability distribution.
In Experiment 1, students learned the general procedure for how to solve these problems by either repeatedly recalling the procedural steps or by simply studying them. The retrieval practice condition produced better memory for the procedure on an immediate test compared to the study only condition. In Experiment 2, students engaged in the same learning activities as Experiment 1, but the test focused on their problem- solving ability. Students who practiced retrieval of the procedural steps experienced no benefit on the problem-solving test compared to the study only condition. In Experiment 3, students learned to solve Poisson probability problems by studying four worked examples, by studying one worked example and solving three practice problems, or by studying one worked example and solving three practice problems with feedback. Students were tested on their problem-solving ability one week later. The problem- solving learning activities outperformed the worked example condition on the final problem-solving test. Taken together, the results demonstrate a pronounced retrieval practice effect but only when the retrieval-based learning activities necessitated the same mental processing that was required during the final assessment, providing support for the transfer-appropriate processing account.