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1

McGregor, Juliette Elizabeth. "Imaging dynamic biological processes." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609205.

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2

Reichenbach, Tobias. "Dynamic patterns of biological systems." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-84101.

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3

Magi, Ross. "Dynamic behavior of biological membranes." Thesis, The University of Utah, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3680576.

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Анотація:
<p> Biological membranes are important structural units in the cell. Composed of a lipid bilayer with embedded proteins, most exploration of membranes has focused on the proteins. While proteins play a vital role in membrane function, the lipids themselves can behave in dynamic ways which affect membrane structure and function. Furthermore, the dynamic behavior of the lipids can affect and be affected by membrane geometry. A novel fluid membrane model is developed in which two different types of lipids flow in a deforming membrane, modelled as a two-dimensional Riemannian manifold that resists
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4

Waheed, Qaiser. "Molecular Dynamic Simulations of Biological Membranes." Doctoral thesis, KTH, Teoretisk biologisk fysik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-102268.

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Biological membranes mainly constituent lipid molecules along with some proteins and steroles. The properties of the pure lipid bilayers as well as in the presence of other constituents (in case of two or three component systems) are very important to be studied carefully to model these systems and compare them with the realistic systems. Molecular dynamic simulations provide a good opportunity to model such systems and to study them at microscopic level where experiments fail to do. In this thesis we study the structural and dynamic properties of the pure phospholipid bilayers and the phase b
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5

Jones, E. Y. "Structural and dynamic studies on biological macromolecules." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371551.

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6

Abul-Haija, Yousef Mustafa Yousef. "Dynamic supramolecular hydrogels with adaptive biological functionality." Thesis, University of Strathclyde, 2015. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=25997.

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7

Bunyapaiboonsri, Taridaporn. "Dynamic combinatorial chemistry : Exploration using biological receptors." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. http://www.theses.fr/2003STR13065.

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La chimie combinatoire dynamique a été récemment introduite comme une approche nouvelle et attractive pour générer et cribler un grand nombre de bibliothèques de composés en une seule étape. Basé sur l'interconnexion réversible entre les composés de la bibliothèque, le processus d'auto-ajustement donne accès à la sélection et à l'amplification du meilleur inhibiteur en présence d'une cible. Au cours de cette thèse, nous avons choisi deux cibles biologiques qui nous ont permis d'explorer l'approche de la chimie combinatoire dynamique. La réversibilité du système a été rendue possible en utilisa
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8

Romanel, Alessandro. "Dynamic Biological Modelling: a language-based approach." Doctoral thesis, Università degli studi di Trento, 2010. https://hdl.handle.net/11572/368272.

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Systems biology investigates the interactions and relationships among the components of biological systems to understand how they globally work. The metaphor “cells as computations†, introduced by Regev and Shapiro, opened the realm of biological modelling to concurrent languages. Their peculiar characteristics led to the development of many different bio-inspired languages that allow to abstract and study specific aspects of biological systems. In this thesis we present a language based on the process calculi paradigm and specifically designed to account for the complexity of signalling n
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9

Cavallo, Antonio. "Four dimensional particle tracking in biological dynamic processes." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964904667.

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10

Lewis, Mark A. "Analysis of dynamic and stationary biological pattern formation." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276976.

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11

Tomazou, Marios. "Towards light based dynamic control of synthetic biological systems." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/44243.

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Анотація:
For the field of synthetic biology, the adaptation of principles, from the well established traditional engineering disciplines, like mechanical and electrical engineering, in order to realise complex synthetic biological circuits, is an intriguing prospect. These principles can enable a forward engineering, rational design and implementation approach, where a system's properties can be predicted or designed in silico followed by the manufacturing of the in vivo system, that can be tested, used or redesigned in the most efficient possible way. Achieving control over these circuits, is one of t
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12

Lindell, Per Ingemar. "Dynamic operation of mammalian cell fed-batch bioreactors." Thesis, Massachusetts Institute of Technology, 1992. http://hdl.handle.net/1721.1/16509.

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13

Hall, Dennis A. (Dennis Alan) 1970. "Dynamic nuclear polarization of biological systems at high magnetic fields." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/9635.

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Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.<br>Includes bibliographical references.<br>Dynamic nuclear polarization methods were studied at high magnetic field strength and were applied to improve the sensitivity of the nuclear magnetic resonance spectroscopy of biological solids. Studies of the dynamics of electron-nuclear polarization transfer via the solid effect and thermal mixing at 5 Tesla are described for two systems: the free radical BDPA doped into polystyrene and the nitroxide TEMPO in a water:glycerol matrix. A model for thermal mixing at high m
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14

You, Chang Hun. "Learning patterns in dynamic graphs with application to biological networks." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Dissertations/Summer2009/c_you_072309.pdf.

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Thesis (Ph. D.)--Washington State University, August 2009.<br>Title from PDF title page (viewed on Aug. 19, 2009). "School of Electrical Engineering and Computer Science." Includes bibliographical references (p. 114-117).
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15

O'Neill, George C. "Dynamic electrophysiological connectomics." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33502/.

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The human brain can be divided into multiple areas, each responsible for different aspects of behaviour. For a century we have been developing techniques to non-invasively map these areas and their associated functions, a discipline now known as neuroimaging. In recent years the field has undergone a paradigm shift to investigate how the brain communicates with itself; it is widely regarded that healthy brain function relies upon efficient connectivity between different functional areas, and the neuroimaging field has been revolutionised by our ability to estimate this connectivity. Studies in
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16

Gupta, Apoorv. "Dynamic regulation of bacterial metabolic pathways using autonomous, pathway-independent control strategies." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/112511.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 86-91).<br>Metabolic engineering efforts have so far focused on strain optimization through careful metabolic modeling and tinkering with host genomes, through gene knockouts or knockins, to direct flux in desired channels. These efforts have borne fruit with the development of large manufacturing processes for numerous chemicals. The next challenge for metabolic engineering, however, lies in tackling issues as
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17

Valtorta, Davide. "Dynamic torsion test for the mechanical characterization of soft biological tissues." kostenfrei, 2007. http://e-collection.ethbib.ethz.ch/view/eth:29354.

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18

Maksym, Geoffrey N. "Computer controlled oscillator for dynamic testing of biological soft tissue strips." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69742.

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A computer controlled tissue strip oscillator has been constructed for the advanced study of lung parenchyma mechanics. The data acquisition and control are facilitated on a 486 personal computer. The tissue is maintained by a continuously circulating bath of Krebs-Ringer solution at 37$ sp circ$C bubbled with a 95% O$ sb2$ and 5% CO$ sb2$ gas mixture. The oscillator has a useful bandwidth to 20 Hz at 0.5 cm amplitude and step response with no overshoot at all amplitudes. The movement range of the motor is 5 cm with resolution 13.6 $ mu$m. The force resolution is 66 $ mu$N with a range of 0.25
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19

Berry, Richard M. "Possible dynamic roles for the electrostatic force in biological membrane systems." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316866.

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20

Winkler, Pamina M. "Novel planar photonic antennas to address the dynamic nanoarchitecture of biological membranes." Doctoral thesis, Universitat Politècnica de Catalunya, 2020. http://hdl.handle.net/10803/670293.

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The cell membrane is the encompassing protective shield of every cell and it is composed of a multitude of proteins, lipids and other molecules. The organization of the cell membrane is inextricably intertwined with its function, and sensitive to perturbations from the underlying actin cytoskeleton and the extracellular environment at the nano- and the mesoscale. Elucidating the dynamic interplay between lipids and proteins diffusing on the cell membrane, forming transient domains and (re)organizing them according to signals from the juxtaposed inner and outer meshwork, is of paramount interes
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21

Li, Yang Ph D. Massachusetts Institute of Technology. "In vitro model of injury/cytokine-induced cartilage catabolism modulated by dynamic compression, growth factors, and glucocorticoids." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/81669.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The degradation of articular cartilage is the hallmark in the pathogenesis of osteoarthritis (OA). It still remains largely unknown which precise mechanisms initiate cartilage degradation. However, risks factors include traumatic joint injury that results in immediate upregulation of inflammatory cytokines within the joint, as well as direct mechanical damage to the cartilage, factors known to contribute to the onset
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22

R, Kyvik Adriana. "Self-assembled monolayers for biological applications: design, processing, characterization and biological studies." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/666882.

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Self-assembled monolayers (SAMs) on gold surfaces have been designed, processed, characterized and used for specific biological studies. The studies performed include the control of lipid bilayer diffusion, cell adhesion and vascularization studies and also the creation of antimicrobial surfaces. More specifically, dynamic SAMs on surfaces whose properties can be modified with an electrochemical external stimulus have been developed and used to interrogate biological systems. The developed platform has been applied to two different applications to overcome present challenges when perfor
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23

Kisiday, John D. (John David) 1970. "In vitro culture of a chondrocyte-seeded peptide hydrogel and the effects of dynamic compression." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29614.

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Thesis (Ph. D. in Bioengineering)--Massachusetts Institute of Technology, Biological Engineering Division, 2003.<br>Includes bibliographical references.<br>Emerging medical technologies for effective and lasting repair of articular cartilage include delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue regeneration. Biocompatible scaffolds assist in providing a template for cell distribution and extracellular matrix accumulation in a three-dimensional geometry. In these studies, a self-assembling peptide hydrogel is evaluated as a potential scaffold for cartila
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24

Al-Atar, Eman. "Dynamic modeling and process design of a membrane enhanced biological phosphorus removal process." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31205.

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The design and operation of the membrane enhanced biological phosphorus removal (MEBPR) process was studied in the current research to utilize the utmost capacity of the membrane system for operating the process under high influent loads. The study was conducted in two parts. In the first part, a dynamic model was calibrated to predict data collected from the UBC MEBPR pilot plant. Then the calibrated model was utilized in simulation studies to develop guidelines for the design and operation of a UCT-type MEBPR process under high flowrates without jeopardizing the effluent quality. The Technic
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25

Li, Song. "Integrate qualitative biological knowledge for gene regulatory network reconstruction with dynamic Bayesian networks." [Ames, Iowa : Iowa State University], 2007.

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26

Martin, Misfeld. "The influence of biological mediators on the dynamic function of the aortic root." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411045.

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27

Kästner, Claudia [Verfasser]. "Ultra-Small Silver Nanoparticles - Dynamic Behavior in Aqueous and Biological Environments / Claudia Kästner." Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1196805822/34.

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28

Cardillo, Giulia. "Fluid Dynamic Modeling of Biological Fluids : From the Cerebrospinal Fluid to Blood Thrombosis." Thesis, Institut polytechnique de Paris, 2020. http://www.theses.fr/2020IPPAX110.

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Dans cette thèse, trois modèles mathématiques ont été proposés, avec l’objectif de modéliser autant d’aspects complexes de la biomédecine, dans lesquels la dynamique des fluides du système joue un rôle fondamental: i) les interactions fluide-structure entre la pulsatilité du liquide céphalo-rachidien et la moelle épinière (modélisation analytique); ii) dispersion efficace d’un médicament dans l’espace sous-arachnoïdien (modélisation numérique); et iii) la formation et l’évolution d’un thrombus au sein du système cardiovasculaire (modélisation numérique).Le liquide céphalorachidien est un fluid
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29

Swensen, Adam Clayton. "Investigation of Dynamic Biological Systems Using Direct Injection and Liquid Chromatography Mass Spectrometry." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6574.

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In biological systems, small changes can have significant impacts. It is, therefore, very important to be able to identify these changes in order to understand what is occurring in the organism. In many cases, this is not an easy task. Mass spectrometry has proven to be a very useful tool in elucidating biological changes even at a very small scale. Several different mass spectrometry based techniques have been developed to discover and investigate complex biological changes. Some of these techniques, such as proteomics, have been through years of development and have advanced to the point tha
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30

Guner, Ugur. "Identification of topological and dynamic properties of biological networks through diverse types of data." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41116.

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It is becoming increasingly important to understand biological networks in order to understand complex diseases, identify novel, safer protein targets for therapies and design efficient drugs. 'Systems biology' has emerged as a discipline to uncover biological networks through genomic data. Computational methods for identifying these networks become immensely important and have been growing in number in parallel to increasing amount of genomic data under the discipline of 'Systems Biology'. In this thesis we introduced novel computational methods for identifying topological and dynamic propert
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31

Loya, Adil. "Large scale dynamic molecular modelling of metal oxide nanoparticles in engineering and biological fluids." Thesis, University of Hertfordshire, 2015. http://hdl.handle.net/2299/15336.

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Nanoparticles (NP) offer great merits over controlling thermal, chemical and physical properties when compared to their micro-sized counterparts. The effectiveness of the dispersion of the NP is the key aspect of the applications in nanotechnology. The project studies the characterization and modification of functional NPs aided by the means of large scale molecular thermal dynamic computerized dispersing simulations, in the level of Nanoclusters (NC). Carrying out NP functionality characterisation in fluids can be enhanced, and analysed through computational simulation based on their interact
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32

Zhang, Bai. "Modeling and Characterization of Dynamic Changes in Biological Systems from Multi-platform Genomic Data." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/29111.

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Анотація:
Biological systems constantly evolve and adapt in response to changed environment and external stimuli at the molecular and genomic levels. Building statistical models that characterize such dynamic changes in biological systems is one of the key objectives in bioinformatics and computational biology. Recent advances in high-throughput genomic and molecular profiling technologies such as gene expression and and copy number microarrays provide ample opportunities to study cellular activities at the individual gene and network levels. The aim of this dissertation is to formulate mathematically d
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33

Sundaraj, Kenneth. "Real-time dynamic simulation and 3D interaction of biological tissue : application to medical simulators." Grenoble INPG, 2004. http://www.theses.fr/2004INPG0012.

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L'avènement de l'imagerie médicale et de nouvelles techniques opératoires a bouleversé les méthodes de travail des médecins. Mais ce changement nécessitera une formation renforcée des praticiens et chirurgiens. C'est pourquoi le dévelopment d'outils appropriés comme les simulateurs médico-chirurgicaux se fait de plus en plus ressentir. Dans ce cadre, nous nous sommes intéressés au problème de la modélisation des phénomènes de déformation de tissu biologique et à la détection des collisions dans un environment virtuel. Dans un premier temps, nous présentons les différents modèles physiques exis
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34

Tesson, Karen Jane. "Dynamic networks : an interdisciplinary study of network organization in biological and human social systems." Thesis, University of Bath, 2006. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434065.

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35

Jumpathong, Watthanachai. "The dynamic interplay between DNA damage and metabolism : the metabolic fate and transport of DNA lesions and novel DNA damage derived from intermediary metabolism." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/93772.

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Анотація:
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2014.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>The work presented in this thesis explores two novel and complementary facets of endogenous DNA damage: the development of biomarkers of inflammation based on metabolites of DNA damage products and the formation of DNA adducts by electrophilic produ
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36

Abuzayan, Khaled Jebril. "Physical and neurophysiological factors influencing dynamic balance." Thesis, Liverpool John Moores University, 2010. http://researchonline.ljmu.ac.uk/5965/.

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Анотація:
Static and dynamic balance are essential in daily and sports life. Many factors have been identified as influencing static balance control, two of which are carrying additional weight and localized muscle fatigue but their influence on dynamic balance in sport activities has not been fully established. Therefore, the aim of this thesis was to investigate the characteristics of dynamic balance in sport related activities, with specific reference to the influence of body mass changes and muscular fatigue. Study one: The objectives of study one (methodological study, n = 5) were to apply the extr
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37

Jang, Seunghee Shelly. "Parameter estimation of stochastic nonlinear dynamic processes using multiple experimental data sets : with biological applications." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/7294.

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Анотація:
The dynamic behavior of many chemical and biological processes is defined by a set of nonlinear differential equations that constitute a model. These models typically contain parameters that need to be estimated using experimental data. A number of factors such as sampling intervals, number of measurements and noise level characterize the quality of data, and have a direct effect on the quality of estimated parameters. The quality of experimental data is rather poor in many processes due to instrument limitations or other physical and economical constraints. Traditional parameter estimation me
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38

Zehraoui, Abderrahman. "ENHANCED BIOLOGICAL OXIDATION OF HYDROPHOBIC COMPOUNDS UNDER DYNAMIC LOAD IN A TRICKLE BED AIR BIOFILTER." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384849490.

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39

Goel, Gautam. "Dynamic flux estimation a novel framework for metabolic pathway analysis /." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31769.

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Анотація:
Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2010.<br>Committee Chair: Voit, Eberhard O.; Committee Member: Butera, Robert; Committee Member: Chen, Rachel; Committee Member: Kemp, Melissa; Committee Member: Neves, Ana Rute. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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40

Vester, Diana [Verfasser], and Udo [Verfasser] Reichl. "Molecular biological analysis of dynamic interactions between influenza viruses and host cells : host cell proteomes and viral replication dynamics / Diana Vester ; Udo Reichl." Magdeburg : Universitätsbibliothek, 2011. http://d-nb.info/1047202816/34.

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41

Harding, Theodor. "A prototype dynamic model for the co-treatment of a high strength simple-organic industrial effluent and coal-mine drainage." Doctoral thesis, Faculty of Engineering and the Built Environment, 2020. http://hdl.handle.net/11427/32660.

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This research study's the use of biological sulfate reduction technologies for the treatment of Sasol Secunda's coal-mine drainage (CMD) using Fischer-Tropsch Reaction Water (FTRW) as a cost-efficient carbon source. The research aims to develop a prototype dynamic model that describes this co-treatment of FTRW and CMD in both a continuously stirred tank reactor (CSTR) biological sulfate reduction (BSR) system and a BSR gas-lift (BSR-GL) integrated system. The BSR-GL system recovers elemental sulfur (S0 ) from the H2S produced and stripped from the BSR unit. Furthermore, this study aims to use
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42

Schneider, Nils [Verfasser], and Matthias [Akademischer Betreuer] Meier. "Development of microfluidic and biological technologies for quantitative and dynamic analysis of gene expression in single cells." Freiburg : Universität, 2018. http://d-nb.info/1189583208/34.

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43

Yamada, Ayako. "Dynamic self-organization of biomolecules in relation to their biological significance : single giant DNA and phospholipid molecules." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/136864.

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44

Lee, Sang-Hyun. "The dynamic nuclear transport regulation of NF-kB and IkBS." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3060116.

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45

Abdullah, Syed Zaki. "Investigation of effect of dynamic operational conditions on membrane fouling in a membrane enhanced biological phosphorus removal process." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/264.

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Анотація:
The membrane bioreactor (MBR) is becoming increasingly popular for wastewater treatment, mainly due to its capability of producing high quality effluent with a relatively small footprint. However, high plant maintenance and operating costs due to membrane fouling limit the wide spread application of MBRs. Membrane fouling generally depends on the interactions between the membrane and, the activated sludge mixed liquor, which in turn, are affected by the chosen operating conditions. The present research study aimed to explore the process performance and membrane fouling in the membrane enhanced
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46

Abdullah, Syed. "Investigation of effect of dynamic operational conditions on membrane fouling in a membrane enhanced biological phosphorus removal process." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/264.

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Анотація:
The membrane bioreactor (MBR) is becoming increasingly popular for wastewater treatment, mainly due to its capability of producing high quality effluent with a relatively small footprint. However, high plant maintenance and operating costs due to membrane fouling limit the wide spread application of MBRs. Membrane fouling generally depends on the interactions between the membrane and, the activated sludge mixed liquor, which in turn, are affected by the chosen operating conditions. The present research study aimed to explore the process performance and membrane fouling in the membrane enhanced
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47

Secrier, Maria [Verfasser], and Lars [Akademischer Betreuer] Steinmetz. "Visualization and analysis strategies for dynamic gene-phenotype relationships and their biological interpretation / Maria Secrier ; Betreuer: Lars Steinmetz." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1177249510/34.

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48

An, Ran. "Using a Combinatorial Peptide Ligand Library to Reduce the Dynamic Range of Protein Concentrations in Complicated Biological Samples." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1388765432.

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49

Figueiredo, Daniel Oliveira. "Differential dynamic logic and applications." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/16841.

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Анотація:
Mestrado em Matemática e Aplicações<br>Na área industrial e habitual usar ferramentas discretas em sistemas cuja evolução e contínua e regida pelas leis da mecânica. Estes sistemas que apresentam tanto comportamento contínuo como discreto são conhecidos como sistemas híbridos. A lógica diferencial dinâmica e uma lógica desenvolvida recentemente para trabalhar com estes sistemas. Neste trabalho, apresentamos a lógica diferencial dinâmica como uma generalização da lógica dinâmica (e, consequentemente, da lógica modal). Também são apresentadas algumas aplicações e discutida a utilidade
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50

Allen, Michael D. "Biological links between cofactors metabolism, signaling and dynamic relationships between iron, manganese, and chlorophyll in the green alga Chlamydomonas reinhardtii /." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1619423491&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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