Дисертації з теми "Biological and Biomedical Applications"
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Beyeler, Felix Martin. "Capacitive micro force sensing for biological and biomedical applications /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18100.
Повний текст джерелаPareta, Rajesh. "Electrohydrodynamic processing and forming of biological systems for biomedical applications." Thesis, Queen Mary, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430795.
Повний текст джерелаTsafnat, Guy Computer Science & Engineering Faculty of Engineering UNSW. "Abstraction and representation of fields and their applications in biomedical modelling." Awarded by:University of New South Wales. School of Computer Science and Engineering, 2006. http://handle.unsw.edu.au/1959.4/24207.
Повний текст джерелаAmbardar, Sharad. "Combining Thermo-plasmonics with Microfluidics for Biological Applications." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7600.
Повний текст джерелаRieter, William J. Lin Wenbin. "Development of inorganic-organic hybrid nanomaterials for biological and biomedical applications." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1979.
Повний текст джерелаTitle from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry." Discipline: Chemistry; Department/School: Chemistry.
Register, Joseph. "SiC For Advanced Biological Applications." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5113.
Повний текст джерелаJia, Xinghua. "Physical Origin of Biological Propulsion and Inspiration for Underwater Robotic Applications." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1483681387845279.
Повний текст джерелаFerrell, Nicholas Jay. "Polymer Microelectromechanical Systems: Fabrication and Applications in Biology and Biological Force Measurements." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1204824627.
Повний текст джерелаRajaraman, Swaminathan. "Silicon MEMS-Based Development and Characterization of Batch Fabricated Microneedles for Biomedical Applications." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin978636001.
Повний текст джерелаChoi, Sungmoon. "Fluorescent noble metal nanodots for biological applications." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37195.
Повний текст джерелаYang, Yaqin. "Surface treated cp-titanium for biomedical applications : a combined corrosion, tribocorrosion and biological approach." Thesis, Châtenay-Malabry, Ecole centrale de Paris, 2014. http://www.theses.fr/2014ECAP0050/document.
Повний текст джерелаTribocorrosion is defined as the study of the interplay between chemical, electrochemical and mechanical processes that leads to a degradation of passivating materials in a corrosive environment. Due to the low density, excellent mechanical properties, high corrosion resistance and good biocompatibility, titanium and its alloys are widely used as dental and orthopedic implants. However, the poor wear resistant and bio-Inert properties limit their further development as more efficient and economic biomedical implants. To improve the corrosion-Wear resistance and even bioactivity of metallic implants, different surface modification methods are imposed in the past decades.The aim of this work is to provide a deep insight in the area of corrosion and tribocorrosion behavior of commercially pure titanium (cp Ti) under the guidance of a tribocorrosion protocol for passivating materials. And then three different surface modification treatments, as:- one-Step thermal oxidation at 650 °C for 48 h in air atmosphere to form a titania (TiO2) film on the surface of cp Ti.- one-Step electrochemical deposition of calcium phosphate (CaP) bioactive film on the surface of cp Ti.- electrochemical deposition of CaP bioactive film followed by thermal oxidation at 650 °C for 6 h in air atmosphere to form a CaP/TiO2 bioceramic film on cp Ti surface.The crystalline phases of the modified films were identified by X-Ray diffraction (XRD). Scanning electron microscopy (SEM) combined with energy dispersive spectroscopy (EDS) was used to characterize the morphology and composition of these films on cp Ti surface. In situ electrochemical measurements, like open circuit potential (OCP), electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization are used to characterize the corrosion behavior of cp Ti samples without or with surface modification. The tribocorrosion behavior was investigated in an aqueous environment by combining a pin-On-Disc tribometer with the in situ electrochemical equipment. The classical tribological parameters could be also recorded under mechanical loaded condition. Surface characterization and analysis (like chemical composition, morphology, roughness...) are carried out before and after each corrosion and tribocorrosion test. A protocol for the culture of cells on the surface of titanium was validated, basing on the preliminary experimental results
Mushonga, Paul. "Fabrication of type-I indium-based near-infrared emitting quantum dots for biological imaging applications." University of the Western Cape, 2013. http://hdl.handle.net/11394/8271.
Повний текст джерелаSemiconductor nanocrystals or quantum dots (QDs) are fluorescent nanometer-sized particles which have physical dimensions that are smaller than the excitonic Bohr radius, large surface area-to-volume ratios, broad absorption spectra and very large molar extinction coefficients. Biomedical applications of QDs are mainly based on II-VI QDs containing cadmium, such as CdSe/ZnS. These cadmium-based systems are associated with high toxicity due to cadmium. As a result, potential replacements of cadmium-based QDs in biological applications are needed. In this study, InP/ZnSe QDs were synthesized for the first time using a one-pot hot injection method. Furthermore, a growth-doping method was used for silver, cobalt and iron incorporation into the InP core. Water compatibility was achieved through ligand exchange with 3- mercaptopropionic acid. In vitro cytotoxicity and imaging/internalization of the as-prepared MP A-InP/ZnSe and MP A-capped CdTe/ZnS QDs were evaluated. InP/ZnSe QDs were successfully synthesized with ZnSe shell causing a 1.4 times reduction in trap-related emission.
Maurer, Elizabeth Irene. "SURFACE MODIFICATION OF CARBON STRUCTURES FOR BIOLOGICAL APPLICATIONS." Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1292621438.
Повний текст джерелаKu, Geng. "Photoacoustic and thermoacoustic tomography: system development for biomedical applications." Texas A&M University, 2004. http://hdl.handle.net/1969.1/3181.
Повний текст джерелаThakkar, Amit. "Combinatorial Synthesis, Sequencing, and Biological Applications of Peptide and Peptidomimetic Libraries." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1259775104.
Повний текст джерелаReed, Stephen. "Synthesis and characterisation of novel glycosidase substrates and evaluation of applications in biomedical science." Thesis, Northumbria University, 2010. http://nrl.northumbria.ac.uk/1101/.
Повний текст джерелаBatra, Sumit. "Innovative Purification Protocol for Heparin Binding Proteins: Relevance in Biopharmaceutical and Biomedical Applications." TopSCHOLAR®, 2011. http://digitalcommons.wku.edu/theses/1062.
Повний текст джерелаBillade, Nilesh S. "Mechanical Characterization, Computational Modeling and Biological Considerations for Carbon Nanomaterial-Agarose Composites for Tissue Engineering Applications." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1250519199.
Повний текст джерелаEhrensberger, Mark T. "The in-vitro biological and electrochemical interactions of electrically polarized commercially pure titanium used for orthopedic and dental applications." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available, full text:, 2008. http://wwwlib.umi.com/cr/syr/main.
Повний текст джерелаSmith, Kathryn Elizabeth. "Tailoring the toughness and biological response of photopolymerizable networks for orthopaedic applications." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37300.
Повний текст джерелаAmengual-Rigo, Pep. "In silico design of antibodies for biomedical applications." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672944.
Повний текст джерелаBracewell, Daniel Gilbert. "The use of an optical biosensor for the real-time monitoring of product and product variants in biological process streams and applications for control." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314156.
Повний текст джерелаHsu, Shu-hao. "The Biological Functions of miR-122 and its Therapeutic Application in Liver Cancer." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338316658.
Повний текст джерелаLee, Jin-Hwan. "MEMS Needle-Type Multi-Analyte Microelectrode Array Sensors for In Situ Biological Applications." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1212146149.
Повний текст джерелаHuang, Regina. "Red-emitting carbon dots and their biological application as antifungal/anti-biofilm agent." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/745.
Повний текст джерелаAntonelli, Maria Rosaria. "Biomedical applications of polarimetric imaging contrast. Initial studies for scattering media and human tissues." Phd thesis, Ecole Polytechnique X, 2011. http://pastel.archives-ouvertes.fr/pastel-00652201.
Повний текст джерелаYudina, Tetyana. "Synthesis, kinetic control and properties engineering of cerium oxide nanoparticles for biomedical applications." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/386525.
Повний текст джерелаThe current Doctoral Thesis is the fruit of collaboration between the Catalan Institute of Nanoscience and Nanotechnology (ICN2) and the Hospital Clinic of Barcelona, involved in the project “Marató TV3 2012”, with the objective to apply Cerium oxide nanoparticles (CeO2 NPs) as a new therapeutic tool for tissue regeneration in liver diseases. CeO2NPs is a fascinating inorganic material with many applications and more to come. What makes nanoceria very appealing is its high capacity to buffer electrons from an oxidant/reducing environment due to the unfilled 4f electronic structure. This is due to its easy ability of being oxidized and reduced, followed by the capture or release of oxygen or reactive oxygen species (ROS and free radicals as OH·). As a result, nanoceria behaves as a natural electron sponge. Note that ROS disbalance takes place in an enormous number of human diseases. Also, the overproduction of ROS is critical in neurodegeneration. Despite the appealing redox catalytic capacity of CeO2 NPs, an important controversy upon biological effects of CeO2 has been numerously reported. During this Thesis, the existent methods of nanoceria preparation have been analyzed in detail, as well as the quality of the obtained products and the toxicological aspects of both (the processes and the products). This Doctoral research has been focused in overtaking the existent problematics of the nanoceria toxicity (due to aggregation of NPs, toxic surfactant or solvent, or contamination with endotoxin) and offering suitable solutions, in order to take full advantage of the antioxidant CeO2NPs properties in biomedical research and applications. Thus, the current work has been focused on the study of physicochemical and biochemical properties of CeO2 NPs, to optimize the preparation methods and the obtained product, in an environmentally-friendly way (Chapter 2, Annex 2). The optimization of the NPs size and monodispersity (Chapter 2); as well as the evaluation of the correspondent antioxidant activity (Chapter 3) were also performed. Finally, the in-vivo biodistribution study of CeO2 NPs, as well as their effects on inflammatory and fibrogenic mediators were evaluated at molecular and cellular level, demonstrating that administration of CeO2 NPs could be of therapeutic value in liver diseases (Annex 3).
Vivo, Llorca Gema. "Mesoporous silica and gold-based nanodevices: new controlled delivery platforms for biomedical applications." Doctoral thesis, Universitat Politècnica de València, 2021. http://hdl.handle.net/10251/172713.
Повний текст джерела[CA] La present tesi doctoral titulada "Mesoporous silica and gold-based nanodevices: new controlled delivery platforms for biomedical applications" se centra en el disseny, síntesi, caracterització i avaluació de diferents nanodispositius híbrids orgànic-inorgànics. En concret, s'utilitzen com a suport nanopartícules mesoporoses de sílice i nanopartícules d'or per a la seua aplicació biomèdica, en concret en el camp del càncer de mama. En el primer capítol s'introdueix el marc general en el qual s'engloben els estudis realitzats. Es presenten els conceptes relacionats amb la nanotecnologia i nanomedicina, així com la interacció de les nanopartícules a nivell biològic amb l'organisme i les cèl·lules. Finalment, s'introdueixen conceptes bàsics del càncer de mama i l'aplicació de nanomaterials com a teràpia. A continuació, en el segon capítol, s'exposen els objectius de la present tesi doctoral que són abordats en els següents capítols experimentals. En el tercer capítol es descriu el primer nanomaterial utilitzat per a l'alliberament controlat de dos inhibidors (navitoclax i S63845) de les proteïnes anti-apoptòtiques de la família Bcl-2. Aquest sistema s'ha dissenyat amb l'objectiu de superar la resistència a navitoclax en un model cel·lular de càncer de mama triple negatiu. En concret, s'han preparat nanopartícules mesoporoses de sílice carregades amb navitoclax i S63845, i funcionalitzades amb un aptàmer dirigit a la proteïna de superfície MUC1, que actua com a porta molecular. En aquest treball hem demostrat que les nanopartícules dissenyades són internalitzades preferentment per cèl·lules tumorals de càncer de mama. També hem demostrat la capacitat de les nanopartícules de revertir la resistència a navitoclax en un model cel·lular de càncer de mama triple negatiu. A més, posem de manifest la disminució del principal efecte advers (trombocitopènia) associat a l'administració del navitoclax en la seua formulació lliure, gràcies a l'encapsulació en les nanopartícules. En el capítol quatre es presenta un sistema sensible a pH per a l'alliberament controlat d'una càrrega fluorescent i la maquinària d'edició gènica basada en el sistema CRISPR/Cas9, dirigit a l'edició gènica del gen codificant de la proteïna fluorescent verda (GFP, del anglés gren fluorescent protein). El nanodispositiu està constituït per nanopartícules mesoporoses de sílice carregades amb rodamina B, funcionalitzades amb polietilenimina i revestides amb el plàsmid codificant del sistema CRISPR/Cas9. En aquest treball s'ha demostrat la fuga lisosomal de les nanopartícules, mediat per l'efecte esponja de protons de la PEI. Així mateix, vam mostrar un nanodispositiu pioner en el seu camp, basat en nanopartícules mesoporoses de sílice, capaç de realitzar la doble funció de dur a terme l'edició del gen codificant de la GFP i l'alliberament exitós de la càrrega fluorescent. En el cinqué i últim capítol experimental es proposa una nova aproximació per a realitzar una teràpia enzimàtica prodroga emprant nanopartícules d'or com a transportadors enzimàtics. En aquest cas, s'aborda la funcionalització de nanopartícules d'or amb l'enzim peroxidasa de rave (HRP, del anglés horseradish peroxidase), capaç de transformar la prodroga innòcua àcid indol-3-acètic en espècies radicals que resulten tòxiques per a les cèl·lules tumorals. En aquest capítol s'ha demostrat l'efecte terapèutic del nanodispositiu en combinació amb la prodroga en models cel·lulars de càncer de mama dels subtipus luminal A i triple negatiu. A més, s'ha confirmat l'eficàcia terapèutica del sistema en esferoides tumorals formats per cèl·lules de càncer de mama triple negatiu. Finalment, en el capítol sis es presenten les conclusions extretes del desenvolupament d'aquesta tesi doctoral. Els resultats obtinguts en aquesta tesi contriburan al desenvolupament de nous nanomaterials intel·ligents amb aplicació en diverses àrees de la nanomedicina.
[EN] This Ph.D. thesis entitled "Mesoporous silica and gold-based nanodevices: new controlled delivery platforms for biomedical applications" is focused on the design, synthesis, characterisation, and evaluation of several hybrid organic-inorganic nanomaterials. We have developed mesoporous silica nanoparticles and gold nanoparticles for biomedical applications, specifically in the breast cancer area. The first chapter includes an overview of the concepts related to the research performed. Introductory notions about nanotechnology and biomedicine are presented, as well as the basis of the interactions of nanoparticles with biological systems. Finally, breast cancer disease and the application of nanomaterials as therapy are described. Next, in the second chapter, the objectives addressed in the following experimental chapters are displayed. In the third chapter, we present the first nanomaterial for the controlled delivery of two inhibitors (navitoclax and S63845) of the Bcl-2 anti-apoptotic proteins. This nanosystem has been designed to overcome navitoclax resistance in a triple-negative breast cancer cellular model. We have prepared mesoporous silica nanoparticles loaded with navitoclax and S63845 and functionalised with an aptamer targeting MUC1 surface protein as a molecular gate. In this work, the specific targeting of the nanodevice to breast cancer cells has been demonstrated. The ability to overcome navitoclax resistance has been shown in navitoclax-resistant triple-negative breast cancer cells. Furthermore, navitoclax encapsulation in the nanoparticles has proved to reduce the main adverse effect (thrombocytopenia) associated with free formulated drug administration. In the fourth chapter, we describe a pH-responsive nanosystem for the controlled co-delivery of a fluorescent cargo and the genome-editing machinery based on CRISPR/Cas9, which targets the green fluorescent protein (GFP) coding gene. The nanodevice consists of mesoporous silica nanoparticles loaded with rhodamine B, functionalised with polyethyleneimine, and capped with the CRISPR/Cas9 plasmid. In the present work, we have shown the lysosomal scape capacity of the nanodevice enhanced by the proton sponge effect of PEI. We have also demonstrated a pioneering mesoporous silica-based nanodevice efficient in the simultaneous genome editing of the GFP gene (as a model gene) and the successful release of a fluorescent cargo (as a model drug). In the fifth and last experimental chapter, we propose a new approximation to develop enzyme prodrug therapy using gold nanoparticles as enzyme carriers. In this case, we use gold nanoparticles functionalised with the enzyme horseradish peroxidase (HRP), which transforms the non-toxic prodrug indol-3-acetic acid into radical species toxic to tumour cells. In this chapter, the therapeutic effect of the nanodevice in combination with the prodrug has been demonstrated in two breast cancer cell subtypes (luminal A and triple-negative breast cancers). Also, the therapeutic effect of the material has been corroborated in multicellular tumour spheroid-like cultures formed by triple-negative breast cancer cells. Finally, in the sixth chapter, the conclusions derived from the presented studies and the general conclusions of this Ph.D. thesis are released. The obtained results will promote the development of new smart nanomaterials with diverse biomedical applications.
Gema Vivo-Llorca thanks the Generalitat Valenciana for her fellowship ACIF/2017/072. Vicente Candela-Noguera thanks the Spanish Government for his fellowship FPU15/02753. We would like to thank Servier for the workart used in the figures of this manuscript (Servier Medical Art https://smart.servier.com/). We thank the Spanish Government (project RTI2018-100910-B-C41 (MCUI/AEI/FEDER, UE); SAF2017-84689-R-B (MCUI/AEI/FEDER, UE)) and the Generalitat Valenciana (project PROMETEO/2018/024 and PROMETEO/2019/065) for support.
Vivo Llorca, G. (2021). Mesoporous silica and gold-based nanodevices: new controlled delivery platforms for biomedical applications [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/172713
TESIS
Porret, Estelle. "Applications des nanoclusters de métaux nobles pour lediagnostic et la thérapie ciblée du cancer Hydrophobicity of Gold Nanoclusters Influences Their Interactions with Biological Barriers Metal nanoclusters for biomedical applications : toward in vivo studies." Thesis, Université Grenoble Alpes (ComUE), 2019. https://thares.univ-grenoble-alpes.fr/2019GREAV034.pdf.
Повний текст джерелаGold nanoparticles (Au NPs) have shown promising results in nanomedicine applied to oncology. They are capable of accumulating in tumor areas, inducing a therapeutic effect by delivering drugs or a photo-/radiotherapeutic effect thanks to their energy absorption properties. They also allow diagnosis by different imaging techniques. This dual activity defines them as theranostic agents. Gold nanoclusters (Au NCs) define an interesting sub-family of Au NPs. They are composed of about ten to hundred gold atoms stabilized by organic molecules. Their size smaller than ~8 nm allows them to be eliminated by the kidneys and to exhibit photoluminescence (PL) properties until infrared wavelengths, which are suitable for in vivo optical imaging. They can also induce cell death under irradiation due to the intrinsic properties of gold. Their optical features, pharmaco-kinetic and tumor accumulation are highly sensitive to size and surface chemistry modification. Currently, preclinical results are not sufficient for clinical transfer and it is necessary to improve the characterization of Au NCs and to study their behaviour in vitro and in vivo.In this context, my thesis project focused on the functionalization of Au NCs in order to improve their accumulation in tumors. The first strategy is based on the self-aggregation of Au NCs in the tumor microenvironment. For this purpose, the surface of the Au NCs was either functionalized with i) molecules promoting bioorthogonal click chemistry reactions, or ii) complementary oligonucleotides that can hybridize. The self-aggregation of Au NCs in solution confirmed the increase in PL by inter-particle energy transfer. The self-agregation of Au NCs could potentially improve the therapeutic effect, but the Au NCs still need to be characterized in vivo. The second strategy consisted in increasing the affinity of Au NCs for cells by adding controlled amounts of arginine on their surface. Indeed, arginine is known to promote electrostatic interaction with plasma membranes and cellular internalization. We have determined the maximum arginine threshold per Au NCs, allowing to increase the PL while keeping their small size with high colloidal stability. The best candidates have a high capacity for electrostatic interaction with artificial membranes even in the presence of serum, suggesting that the opsonization of Au NCs is low. Their interaction (< 5min) and internalization (<30 min) capacities are rapid, and have been confirmed on human melanoma cells in vitro, without significant toxicity. However, according to a study on irradiated spheroids performed in our team, the addition of arginines would have a "trapping" effect on the production of reactive oxygen species, reducing the radiosensitizing power of Au NCs. The presence of positive charges on Au NCs containing arginines and their internalization capacity also can serve in vitro to deliver anionic polymers and biomolecules such as siRNA. However, these Au NCs administered intravenously to tumor-bearing mice are eliminated extremely rapidly by the kidneys, thus reducing their ability to accumulate in tumors. This work showed that the functionalization of Au NCs strongly influences their optical and physicochemical properties, their interactions with cells and their theranostic effects. It would be interesting to apply these strategies to Au NCs circulating longer in the blood to demonstrate the effect of these functionalizations on tumor diagnostics and therapy
Sparks, Laura C. "Development and Characterization of Phospholipid Encapsulated Quantum Dot Constructs for Biologic Applications." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/832.
Повний текст джерелаThouvenin, Olivier. "Optical 3D imaging of subcellular dynamics in biological cultures and tissues : applications to ophthalmology and neuroscience." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC169/document.
Повний текст джерелаThis PhD project aims to explore the relationship that might exist between the dynamic motility and mechanical behavior of different biological systems and their biochemical activity. In particular,we were interested in detecting the electromechanical coupling that may happen in active neurons, and may assist in the propagation of the action potential. With this goal in mind, we have developed two highly sensitive optical microscopes that combine one modality that detects sub-wavelength axial displacements using optical phase imaging and another modality that uses a fluorescence path. Therefore, these multimodal microscopes can combine a motility, a mechanical,a structural and a biochemical contrast at the same time. One of this system is based ona multimodal combination of full-field optical coherence tomography (FF-OCT) and allows the observation of such contrast inside thick and scattering biological tissues. The other setup provides a higher displacement sensitivity, but is limited to measurements in cell cultures. In this manuscript, we mainly discuss the development of both systems and describe the various contrastst hey can reveal. Finally, we have largely used our systems to investigate diverse functions of the eye and to look for electromechanical waves in cell cultures. The thorough description of both biological applications is also provided in the manuscript
Nefzi, Amani. "Analysis and dosimetry of the coupling of electromagnetic waves with biological tissues : application to applicator design for biomedical and study of health effects." Thesis, Limoges, 2021. http://www.theses.fr/2021LIMO0011.
Повний текст джерелаThe evolution and increasing use of mobile communications systems was associated with laboratory investigations to study radiofrequency electromagnetic waves exposure safety. In this context, this thesis focuses on the characterization of exposure systems allowinglaboratory in vitro studies on cell models. A dual numerical and experimental approach is implemented to perform the devices dosimetry allowing to determine and control the exposure levels. One of the limitations associated with this dosimetry is due to the micrometric dimensions involved. Therefore, a microscopy technique based on a temperature-dependent fluorescent dye named Rhodamine B was set up and evaluated. This assessment recommends an optimal concentration of the dye at around 50 μM. After calibration, it is possible to estimate the specific absorption rate (SAR) from the temperature variation, even for low levels of SAR (< W / kg) with a spatial resolution of less than ten micrometers i.e. microdosimetry. The two main exposure systems studied, based on microelectrode arrays (MEA), allow the recording of neurons electrophysiological activity. Exposure to electromagnetic waves is achieved simultaneously by inserting these MEAs into TEM cells exposure systems. Dosimetry carried out at 1.8 GHz shows a higher sensitivity of one MEA to its environment. It was shown that the modifications made to the second MEA such as its aperture size and ground planes, have reduced the proximity environment influence. The microdosimetry demonstrated good homogeneity of the SAR between the electrodes with an estimated value of 7 ± 1 W / kgfor 1 W incident power. Finally, a microfluidic exposure device based on a coplanar waveguide was characterized under static conditions
Guo, Lilin. "A Biologically Plausible Supervised Learning Method for Spiking Neurons with Real-world Applications." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2982.
Повний текст джерелаAghaaminiha, Mohammadreza. "Application of Molecular Simulations and Machine Learning Methods to Study Biological and Metallic Interfaces in Aqueous Environment." Ohio University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou162818080313617.
Повний текст джерелаAghaaminiha, Mohammadreza. "Application of Molecular Simulations and Machine Learning Methods to Study Biological and Metallic Interfaces in Aqueous Environment." Ohio University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou162818080313617.
Повний текст джерелаNenot, Marie-Laure. "DIANE, un code de simulation de l'interaction des neutrons avec la matiere vivante. Applications aux faibles doses de neutrons rapides sur des cellules tumorales humaines." Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2003. http://tel.archives-ouvertes.fr/tel-00003719.
Повний текст джерелаGrimes, Logan. "DEVELOPENT OF A PHOSPHOLIPID ENCAPSULATION PROCESS FOR QUANTUM DOTS TO BE USED IN BIOLOGIC APPLICATIONS." DigitalCommons@CalPoly, 2014. https://digitalcommons.calpoly.edu/theses/1237.
Повний текст джерелаPitre, Stéphanie. "Développement d'un imageur gamma haute résolution pour la cancérologie : du traitement chirurgical du cancer à l'étude sur petits animaux." Phd thesis, Université Paris-Diderot - Paris VII, 2002. http://tel.archives-ouvertes.fr/tel-00003622.
Повний текст джерелаChild, Hannah. "Nanoparticles for biomedical applications." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3583/.
Повний текст джерелаHughes-Brittain, Nanayaa Freda. "Photoembossing for biomedical applications." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8294.
Повний текст джерелаAbbas, Aiman Omar Mahmoud. "Chitosan for biomedical applications." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/771.
Повний текст джерелаMarblestone, Adam Henry. "Designing Scalable Biological Interfaces." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11381.
Повний текст джерелаGulati, Neetu Mehek. "Characterizing and Manipulating Biological Interactions of Viruses." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1505991239211632.
Повний текст джерелаKaats, Adrian. "Estimation of biological ion channel permeation properties." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110344.
Повний текст джерелаCette thèse présente des méthodes pour évaluer plus précisément le coefficient de diffusion utilisé dans les simulations fondées sur la théorie du continuum de la perméation des canaux ioniques. On établit tout d'abord un cadre mathématique pour le calcul des coefficients de diffusion d'espèces sphériques lors d'une diffusion restreinte à un contenant arbitrairement délimité. On présente ensuite des méthodes pour standardiser les coordonnées d'atomes formant des canaux ioniques biologiques. En utilisant ces coordonnées standardisées, on démontre comment on peut représenter la surface d'un pore intérieur d'un canal ionique. On utilise alors cette représentation comme contenant ainsi que le cadre mathématique présenté précédemment afin d'évaluer le coefficient de diffusion dans le pore du canal. On applique ensuite ces méthodes à la gramicidine A (GA) pour calculer le coefficient de diffusion du pore de la GA, avec des résultats comparables à ceux obtenus par des simulations de dynamique moléculaire beaucoup plus complexes et coûteuses. Finalement, à l'aide du cadre mathématique servant à calculer le coefficient de diffusion, on formule des prévisions à propos de la diffusion dans des espaces très restreints, et on considère leur incidence sur la conception appliquée aux canaux ioniques.
Ung, Warren Lloyd. "Microfluidic Methods for High-Throughput Biological Screening." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845504.
Повний текст джерелаEngineering and Applied Sciences - Engineering Sciences
Chin, Suk Fun. "Superparamagnetic nanoparticles for biomedical applications." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0128.
Повний текст джерелаCapuccini, Chiara <1979>. "Biomimetic Materials for Biomedical Applications." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1447/.
Повний текст джерелаZurutuza, Amaia. "Novel microgels for biomedical applications." Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248836.
Повний текст джерелаCantini, Eleonora. "Switchable surfaces for biomedical applications." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8040/.
Повний текст джерелаChristiansen, Michael G. (Michael Gary). "Magnetothermal multiplexing for biomedical applications." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111248.
Повний текст джерелаThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 170-176).
Research on biomedical applications of magnetic nanoparticles (MNPs) has increasingly sought to demonstrate noninvasive actuation of cellular processes and material responses using heat dissipated in the presence of an alternating magnetic field (AMF). By modeling the dependence of hysteresis losses on AMF amplitude and constraining AMF conditions to be physiologically suitable, it can be shown that MNPs exhibit uniquely optimal driving conditions that depend on controllable material properties such as magnetic anisotropy, magnetization, and particle volume. "Magnetothermal multiplexing," which relies on selecting materials with substantially distinct optimal AMF conditions, enables the selective heating of different kinds of collocated MNPs by applying different AMF parameters. This effect has the potential to extend the functionality of a variety of emerging techniques with mechanisms that rely on bulk or nanoscale heating of MNPs. Experimental investigations on methods for actuating deep brain stimulation, drug release, and shape memory polymer response are summarized, with discussion of the feasibility and utility of applying magnetothermal multiplexing to similar systems. The possibility of selective heating is motivated by a discussion of various models for heat dissipation by MNPs in AMFs, and then corroborated with experimental calorimetry measurements. A heuristic method for identifying materials and AMF conditions suitable for multiplexing is demonstrated on a set of iron oxide nanoparticles doped with various concentrations of cobalt. Design principles for producing AMFs with high amplitude and ranging in frequency from 15kHz to 2.5MHz are explained in detail, accompanied by a discussion of the outlook for scalability to clinically relevant dimensions. The thesis concludes with a discussion of the state of the field and the broader lessons that can be drawn from the work it describes.
by Michael G. Christiansen.
Ph. D.