Дисертації з теми "BioInorganic Chemistry, Medicinal Chemistry"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 дисертацій для дослідження на тему "BioInorganic Chemistry, Medicinal Chemistry".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Paiva, Raphael Enoque Ferraz de 1989. "Complexos metálicos com nimesulida : síntese, caracterização e aplicações em química bioinorgânica medicinal." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249124.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química
Made available in DSpace on 2018-08-25T01:00:34Z (GMT). No. of bitstreams: 1 Paiva_RaphaelEnoqueFerrazde_M.pdf: 15807547 bytes, checksum: e13f0a8a3bbde08ba558ac7cdb13c9a5 (MD5) Previous issue date: 2014
Resumo: Complexos metálicos têm sido estudados quanto as suas propriedades medicinais há décadas. Neste trabalho, dois complexos inéditos de Ag(I) e Pt(II) foram sintetizados com o anti-inflamatório nimesulida (NMS), e avaliados como agentes antibacterianos e antitumorais. O complexo Ag-NMS (AgC13H11N2O5S) apresenta o ligante em uma coordenação bidentada à prata pelos átomos de N e O do grupo sulfonamida. A estrutura proposta foi confirmada por DFT. Devido à baixa solubilidade em água, foi preparado um complexo de inclusão de Ag-NMS em b-CD, pelo método de co-evaporação. Utilizando o método de Scatchard, foi determinado o valor de Ka = 370 2 L mol. Estudos de RMN por correlação H-H através do espaço mostram que a inclusão ocorre pelo grupo fenoxi da NMS. Já o complexo Pt-NMS (PtC26H22N4O10S2) apresenta dois ligantes, coordenados pelos átomos de N e O do grupo sulfonamida, para cada Pt(II). A DFT indica que o isômero N, O trans é o mais estável. O complexo Ag-NMS apresentou valores de MIC na faixa de 15,0-120 mmol L sobre cepas de Pseudomonas aeruginosa, Escherichia col e Staphylococcus aureus. O CE-[(Ag-NMS)·b-CD], embora mais solúvel em água do que o Ag-NMS, não apresentou atividade antibacteriana nas concentrações testadas. Os complexos Ag-NMS e Pt-NMS mostraram-se citotóxicos sobre células normais (Balb/c 3T3) e tumorais (SK-Mel 103 e Panc-1), porém o Pt-NMS foi significativamente mais seletivo contra as linhagens tumorais. Os ensaios de intercalação com EtBr e a avaliação da estrutura do DNA por dicroísmo circular indicam que o DNA não é um alvo biológico para o complexo Pt-NMS, indicando um mecanismo de ação diferente da cisplatina
Abstract: Metal complexes have been studied regarding its medicinal properties for decades. In this work, novel complexes of Ag(I) and Pt(II) with the anti-inflammatory nimesulide were synthesized and evaluated regarding their antibacterial and antitumoral properties. The Ag-NMS complex (AgC13H11N2O5S) shows the ligand in a bidentate coordination mode, bound to silver through the N and O atoms of the sulfonamide group. The proposed structure was confirmed by DFT. Due to its poor solubility in water, the Ag-NMS complex was included in b-CD, by co-evaporation. The Ka = 370 2 L mol was determined using the Scatchard method. Studies by H-H NMR correlation through space shows the inclusion of NMS by the fenoxi group. The Pt-NMS complex (PtC26H22N4O10S2) contain two ligands, coordinated through the N and O atoms of the sulfonamide group, for each Pt(II). DFT studies indicate that the N,O trans isomer is the most stable. The Ag-NMS complex presents MIC values in the range 15.0-120 mmol L over Pseudomonas aeruginosa, Escherichia coli e Staphylococcus aureus. The inclusion complex CE-[(Ag-NMS)·b-CD], although more soluble in water than Ag-NMS, shows no antibacterial activity in the tested concentrations. Both complexes were cytotoxic against normal (Balb/c 3T3) and tumor (SK-Mel 103 and Panc-1) cells, but the Pt-NMS complex was significantly more selective against tumor cells. The EtBr competitive intercalation assay and the evaluation of CT-DNA structure using circular dichroism show that DNA is not a biological target for the Pt-NMS complex, indicating a mechanism of action different of the cisplatin one
Mestrado
Quimica Inorganica
Mestre em Química
Karges, Johannes. "Design, Synthèse, Caractérisation et Evaluation Biologique de Complexes Métalliques pour la Thérapie Photodynamique à un et deux Photons." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEC028.
Повний текст джерелаCancer is and remains a major health problem all around the world. Statistics over the last decades of GLOBOCAN and WHO shows that it is the leading cause of death in developed countries and the second most lethal disease in non-developed countries. It is suggested that the increasing impact of cancer on the life expectation and life quality in developed countries is a result of population aging and growth and adoption of an unhealthy life style such as for example smoking or physical inactivity. While the number of reported patients diagnosed with cancer is from year to year rising, significant improvements in the treatment and life expectations of patients were made. To date, cancer is commonly treated by surgery, chemotherapy, immunotherapy, radiotherapy or a combination of these to overcome the limitations of a single treatment. To attenuate the side effects of such treatments and to increase the overall survival of the patient, much research efforts are currently devoted towards the development of new therapeutic strategies and drugs. Recently, photodynamic therapy (PDT) has received increasing attention as a complementary technique for the treatment of a variety of cancers. During a therapeutic session, a photoactivable drug is administered to a patient. Afterward, this drug is locally activated upon light exposure. Despite the success of the currently approved drugs, the ability of these are limited, among others, due to their poor biological stability, solubility and cancer selectivity. To overcome these limitations, in this work, different types of new metal complexes were investigated as potential drug candidates
Keter, Frankline Kiplangat. "Pyrazole and pyrazolyl palladium(II) and platinum(II) complexes: synthesis and in vitro evaluation as anticancer agents." Thesis, University of the Western Cape, 2004. http://etd.uwc.ac.za/index.php?module=etd&.
Повний текст джерелаPettenuzzo, Nicolò. "Steps forwards to a new type of oncotherapy: from the solution chemistry of Au(III)-dithiocarbamato complexes to the design and development of innovative Au(III)- and Cu(II)-based cancer-targeting agents." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426685.
Повний текст джерелаAl fine di superare gli effetti collaterali della chemioterapia, ma rimanendo fortemente convinti del ruolo potente che può svolgere la chimica inorganica applicata alla medicina, la Prof.ssa Fregona e i suoi collaboratori si sono occupati, fin dai primi anni 2000, dello sviluppo di una serie di molecole a base metallica con leganti ditiocarbammici, in particolare contenenti centri metalli quali Au(III), Ru(III) e Cu(II). Queste si sono rivelate altamente attive in vitro verso un gran numero di linee cellulari tumorali umane e meno tossiche, in vivo, rispetto ad altri chemioterapici di uso clinico. Benchè negli ultimi anni siano stati condotti diversi studi approfonditi sulla chimica di questi potenti composti di coordinazione, alcuni aspetti rimangono ancora da spiegare. Nella prima parte di questo lavoro, si presenta uno studio completo sulla sintesi, la caratterizzazione e sulla chimica in soluzione di otto complessi ditiocarbammici di Au(III), che hanno rivelato una reattivià peculiare ed affascinante. Inoltre, sette di essi hanno dimostrato interessanti proprietà biologiche in vitro verso una linea cellulare tumorale del cancro colon-rettale. Nella seconda parte del progetto di dottorato, il lavoro si è focalizzato sulla sintesi, la caratterizzazione e la valutazione biologica di nuovi complessi ditiocarbammici di Au(III) e Cu(II), bioconiugati con una funzione molecolare targettante, con l'obiettivo di migliorare l’accumulo di questa classe di molecole all’interno delle cellule cancerose. Al fine di raggiungere questo obiettivo, sono stati scelti tre differenti agenti di targeting, che sfruttano il diverso metabolismo delle cellule neoplastiche rispetto a quelle sane. Nel complesso, sono stati sintetizzati nove diversi composti di coordinazione che sono stati testati come agenti antitumorali in vitro. Fra questi, uno di loro ha dimostrato un'elevata attività citotossica contro una linea cellulare tumorale, aprendo la strada a futuri studi che indagheranno il ruolo della funzionalizzazione targettante nel delivery selettivo del complesso verso i tessuti cancerosi.
PAIOTTA, ALICE. "Synthesis of Glycoderivatives as Molecular Tools in Medicinal Chemistry and Nano-Medicinal Chemistry." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/199137.
Повний текст джерелаThe project carried out during the 3 years-Ph.D. has had the objective to identify and synthesize new glycomimetics as molecular tools to study the Hexosamine Biosynthetic Pathway (HBP), which role is to regulate the proliferation and survival of cancer cells. The project has been funded by AIRC and the principal aim was to identify the Adenocarcinoma of the Pancreatic Duct (PDAC) as the target of research. The synthesis of innovative chemical tools helps the understanding of the HBP pathway and its response in PDAC: new potential inhibitors, which are similar to the natural substrate of enzyme, can be recognized but trick the enzyme and block its activity in order to decrease the UDP-GlcNAc production and consequently modify the protein glycosylation. Due to the important role of the HBP in the cells, alteration of this pathway can bring to alteration of N- and O- glycosylation and activate the Unfolded Protein Response (UPR) during the Endoplasmic Reticulum (ER) stress. The description of the research target helps the understanding of the design of molecular tools: the focus point is the inhibition of the enzyme N-acetylglucosamine-phosphate mutase (AGM1): its inhibition could represent the way to induce apoptosis in cancer cells. Through the Molecular Design, a rational design of potential inhibitors has been done. This design is based on the similarity with the structures of the natural substrate of enzyme AGM1, with some modifications. All of the drawn structures have been used for Molecular Docking in order to get a first virtual screening on the compounds library. Starting from preliminary results of theoretical approach, the synthesis of compounds have been done following three different synthetic strategies. All the steps and reaction condition are described in details and are shown the characterization (1H, 13C NMR spectra, m/z) of all the synthetized compound. The optimization of the analytical method on High Performance Liquid Chromatography is necessary in order to achieve experimental data on the ability of the designed compounds to inhibit the target enzyme, data to be compared to those obtained through a computational theoretical approach. To this aim an HPLC method has been set-up for the quantification of UDP-GlcNAc produced using the cellular extract as enzyme source, and carrying out the reaction with the natural substrates GlcNAc-6P, UTP in the presence or not of the test molecules. Using 10 and 30 µL of extract, three compounds lead to a decrease of production of UDP-GlcNAc. The computational data ”describes” the interaction between the enzyme and the molecules. The calculation of C LogP has confirmed the most apolar character of compound 3B in the acetylated form. Some preliminary evaluation of the effect of compound 2B in a Triple Negative Breast Cancer (TNBC) cell model has been carried out. In conclusion, the study of the target of this research, the HBP pathway, and the focus on the inhibition of AGM1 are the starting point for a complete project, that includes at first the design of a library of compound based on the structural properties of the natural substrate. the “in silico” evaluation of their interaction with the target enzyme, the synthesis and the screening through an enzymatic assay.. The tuning of the strategy of synthesis is important to obtain the compound for the in vitro test. The analytical method with HPLC gives results comparable to the docking scores, and then, after a calculation of C LogP, the test on cells gives the final results of potency of compound 3B (2B the acetylated form). The last part describes the collaboration with CycloLab (Budapest): some compounds of the library possess chemical-physical characteristics that make their passage through cell membrane very harsh: they are very polar and some of them possess negative charges (sulphate, sulphonates, phosphoramidate). This preliminary work is still in progress.
Brophy, Megan Brunjes. "Bioinorganic Chemistry of the Human Host-Defense Protein Calprotectin." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98823.
Повний текст джерелаVita. Cataloged from PDF version of thesis.
Includes bibliographical references.
The human innate immune system responds to bacterial and fungal pathogens by releasing the metal-chelating protein calprotectin (CP) at sites of infection and in the upper layers of the epidermis. CP is a Mn(II)- and Zn(ll)-binding protein. The work described in this thesis elucidates the metal-binding properties of CP, and correlates these properties with in vitro growth inhibition of bacteria and fungi. We report that the metal-binding properties of CP are modulated by Ca(ll), and we propose a working model in which CP responds to physiological Ca(Il)-ion gradients to become a potent Zn(ll)- and Mn(Il)-chelating agent in the extracellular space. Individual chapter summaries follow. Chapter 1: Bioinorganic Chemistry of the Host Pathogen Interaction. Transition metal ions are required for all forms of life. During the course of infection, pathogenic microorganisms must acquire transition metals from the host. Three metals of interest from this standpoint are iron, zinc, and manganese. This chapter describes bacterial metal-ion homeostasis machineries, and metal-requiring processes with a focus on Zn(II) and Mn(II). This chapter then highlights the S100 family of Ca(ll)-binding proteins and discuses the Zn(Il)-, Cu(ll)-, and Mn(Il)-binding properties of S100B, S100A12, S100A7, S10OA15, and S100A8/S100A9. Finally, an overview of the scope of this thesis is presented. Chapter 2: Calcium Ion Gradients Modulate the Zinc(Il) Affinity and Antibacterial Activity of Human Calprotectin. Calprotectin (CP) is a human neutrophil protein that is produced and released by neutrophils at sites of infection, where it prevents the growth of microorganisms by sequestering bioavailable zinc(II) and manganese(II). In this chapter, we present metalbinding studies to elucidate the Zn(ll)-binding properties of CP. We report unique optical absorption and EPR spectroscopic signatures for the interfacial His 3Asp and His 4 sites of human CP by using Co(II) as a spectroscopic probe. Zinc competition titrations employing colorimetric and fluorimetric Zn(II) sensors establish that CP coordinates two Zn(II) ions / CP heterodimer. The Ca(ll)-insensitive Zn(ll) sensor ZP4 is used to determine the Kd of CP for Zn(II) in Ca(Il)-deplete and Ca(Il)-replete conditions. These competition titrations afford apparent Kdsitel = 133 58 pM and Kdsite2 = 185 219 nM in the absence of Ca(II). In the presence of excess Ca(Il) these values decrease to Kd,sitel 5 10 pM and Kd,site2 : 240 pM. In vitro antibacterial assays indicate that the metal-binding sites and Ca(ll)-replete conditions are required to inhibit the growth of Gram-negative and Gram-positive bacteria. We propose a model in which Ca(II) ion gradients modulate the antibacterial activity and Zn(Il)-binding properties of human CP. Chapter 3: High-Affinity Manganese Coordination by Human Calprotectin Is Calcium- Dependent and Requires the Histidine-Rich Site at the Dimer Interface. In this chapter, we report that the His 4 motif at the S10OA8/S100A9 dimer interface of CP is required for high-affinity Mn(II) coordination. We identify a low-temperature EPR spectroscopic signal for this site that is consistent with high-spin Mn(II) in an octahedral coordination sphere. This site could be simulated with zero-field splitting parameters D = 270 MHz and EID = 0.30 (E = 81 MHz). This analysis, combined with studies of mutant proteins, suggests that (A8)Hisl7, (A8)His27, (A9)His9l, (A9)His95 and two as-yet unidentified ligands coordinate Mn(ll) at site 2. These studies support a model in which CP responds to Ca(ll) ion gradients to become a potent metal-ion chelator in the extracellular space. Chapter 4: Contributions of the C-terminal Tail of S100A9 to High-Affinity Manganese Binding by Human Calprotectin. This chapter examines the role of the S100A9 C-terminal tail to high-affinity Mn(ll) coordination by human CP. We present a 16-member mutant family with mutations in the S100A9 C-terminal tail (residues 96-114), which houses three histidine and four acidic residues, to evaluate its contribution to Mn(ll) sequestration. These studies confirm that two His residues at positions 103 and 105 complete the octahedral coordination sphere of CP in solution. Appendix 1: Sequence Alignments of Transition-Metal Binding S100 Proteins. Sequence alignments of S100A7, S100A8, S100A9, S100A12, S100A15, and S100B proteins from multiple organisms are presented. Appendix 2: Characterization of CP Mutant Proteins by Circular Dichroism and Analytical Size Exclusion Chromatography. Additional characterization of CP and mutant proteins employed in Chapters 2-4 is presented. Appendix 3: Structures of Sensors Used In this Work. The structures of Zincon, MagFura-2, Zinpyr-1, and Zinpyr-4 are presented. Appendix 4: Manganese Binding Properties of Human Calprotectin under Conditions of High and Low Calcium. This appendix represents a collaborative work with the Drennan Lab (MIT) and Britt Lab (UC Davis) to study the Mn(Il)-CP complex in low- and high-Ca(II) conditions. We report a crystal structure of Mn(Il)-, Ca(Il)-, and Na(l)-bound CP with Mn(II) exclusively coordinated to the His6 motif. Electron spin-echo envelope modulation and electron-nuclear double resonance experiments demonstrate that the six coordinating histidine residues are spectroscopically equivalent. The observed 15N ( = %/h)y perfine couplings (A) arise from two distinct classes of nitrogen atoms: the coordinating E-nitrogen of the imidazole ring of each histidine (A = [3.45, 3.71, 5.91] MHz) and the distal 6-nitrogen (A = [0.11, 0.18, 0.42] MHz). In the absence of Ca(II), the affinity of CP for Mn(II) drops by two to three orders of magnitude, and Mn(II) coordinates to the His6 site as well as other sites on the protein.
by Megan Brunjes Brophy.
Ph. D. in Biological Chemistry
Uchiyama, Mayara Klimuk. "Estudo de nanopartículas de ouro e de magnetita voltadas para medicina diagnóstica." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-18092015-104822/.
Повний текст джерелаTheranostics has been intensively pursued in recent years using hybrid materials based on nanoparticles conjugated with biomolecules. This is an interesting strategy to increase the selectivity and sensitivity, as well as to improve the currently used methods facilitating their use or creating new ones. Among the various types of nanomaterials, those based on gold and magnetic nanoparticles exhibit interesting chemical and physical properties in the biological environment, differing from that of free drugs or current explored in assay methods. For example, superparamagnetic nanoparticles are excellent contrast agents for magnetic resonance image (MRI) diagnostics because they are safer, present a better contrast efficiency for imaging and can be magnetically accumulated in tissues or tumors using a magnetic field. Numerous in vitro and in vivo toxicity assays were performed to ensure the safety for medical applications. Clearly, these type of applications only will be realized if nanomaterials prove to be nontoxic and biocompatible. This imply an strict control on their structure and composition. However, despite the significant advances in the development of such nanomaterials, there were not found in the literature model systems explaining or that can be used to predict by which sites the protein-nanoparticle binding should take place. In addition, no systematic studies on the factors determining the stability and the functionality of nanobioconjugates (NBC) were found. Thus, this thesis is focused in unveiling the factors responsible for binding/adsorption of proteins on gold nanoparticles and their influence on the colloidal stability of hybrid nanoparticles suspensions while keeping the functionality of biomolecules. In fact, NBC with enhanced properties suitable for the development of diagnostic methods and even for treatment of diseases were obtained. These nanomaterials can improve the ELISA immunoassay, or other diagnosis methods can be developed by using the gold nanoparticles plasmonic properties in association with SERS, SPR and confocal Raman microscopy techniques.
Rajarathinam, Kayathri. "Nutraceuticals based computational medicinal chemistry." Licentiate thesis, KTH, Teoretisk kemi och biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-122681.
Повний текст джерелаQC 20130531
Pujar, P. P. "Chemistry of Indian medicinal plants." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1999. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3410.
Повний текст джерелаYan, Siu-cheong. "Bioinorganic chemistry of antimony : interaction of antimonial with biomolecules /." View the Table of Contents & Abstract, 2004. http://sunzi.lib.hku.hk/hkuto/record/B30575540.
Повний текст джерелаSeifert, S., and J. Van Den Hoff. "Annual Report 2004 - Institute of Bioinorganic and Radiopharmaceutical Chemistry." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-28695.
Повний текст джерелаSeifert, S., and H. Spies. "Annual Report 2003 - Institute of Bioinorganic and Radiopharmaceutical chemistry." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-28959.
Повний текст джерелаJohannsen, Bernd, and Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2002." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-29271.
Повний текст джерелаJohannsen, Bernd, and Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2001." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-29488.
Повний текст джерелаSeifert, Sepp, and Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2000." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-29716.
Повний текст джерелаJohannsen, Bernd, and Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1997." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-30891.
Повний текст джерелаSeifert, Sepp, and Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1996." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-31238.
Повний текст джерелаSeifert, Sepp, and Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1995." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-31653.
Повний текст джерелаJohannsen, Bernd. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1994." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-32143.
Повний текст джерелаJohannsen, Bernd. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1993." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-32438.
Повний текст джерелаJohannsen, Bernd. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1992." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-32587.
Повний текст джерелаYan, Siu-cheong, and 甄肇昌. "Bioinorganic chemistry of antimony: interaction of antimonial with biomolecules." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B4457017X.
Повний текст джерелаSeifert, S., and J. Van Den Hoff. "Annual Report 2004 - Institute of Bioinorganic and Radiopharmaceutical Chemistry." Forschungszentrum Rossendorf, 2005. https://hzdr.qucosa.de/id/qucosa%3A21696.
Повний текст джерелаSeifert, S., and H. Spies. "Annual Report 2003 - Institute of Bioinorganic and Radiopharmaceutical chemistry." Forschungszentrum Rossendorf, 2004. https://hzdr.qucosa.de/id/qucosa%3A21722.
Повний текст джерелаJohannsen, Bernd, and Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2002." Forschungszentrum Rossendorf, 2003. https://hzdr.qucosa.de/id/qucosa%3A21754.
Повний текст джерелаJohannsen, Bernd, and Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2001." Forschungszentrum Rossendorf, 2002. https://hzdr.qucosa.de/id/qucosa%3A21775.
Повний текст джерелаJohannsen, Bernd, and Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1997." Forschungszentrum Rossendorf, 1997. https://hzdr.qucosa.de/id/qucosa%3A21916.
Повний текст джерелаSeifert, Sepp, and Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1996." Forschungszentrum Rossendorf, 1997. https://hzdr.qucosa.de/id/qucosa%3A21950.
Повний текст джерелаSeifert, Sepp, and Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1995." Forschungszentrum Rossendorf, 1996. https://hzdr.qucosa.de/id/qucosa%3A21992.
Повний текст джерелаJohannsen, Bernd. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1994." Forschungszentrum Rossendorf, 1995. https://hzdr.qucosa.de/id/qucosa%3A22041.
Повний текст джерелаJohannsen, Bernd. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1993." Forschungszentrum Rossendorf, 1994. https://hzdr.qucosa.de/id/qucosa%3A22070.
Повний текст джерелаJohannsen, Bernd. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1992." Forschungszentrum Rossendorf, 1993. https://hzdr.qucosa.de/id/qucosa%3A22085.
Повний текст джерелаSeifert, Sepp, and Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2000." Forschungszentrum Rossendorf, 2001. https://hzdr.qucosa.de/id/qucosa%3A21798.
Повний текст джерелаJohannsen, B., and S. Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry, Report July - December 1999." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-30041.
Повний текст джерелаHowson, Suzanne E. "Self-assembly and bioinorganic chemistry of optically pure helical complexes." Thesis, University of Warwick, 2011. http://wrap.warwick.ac.uk/35728/.
Повний текст джерелаJohannsen, B., and S. Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry, Report July - December 1999." Forschungszentrum Rossendorf, 2000. https://hzdr.qucosa.de/id/qucosa%3A21831.
Повний текст джерелаShi, Dong-Fang. "The medicinal chemistry of antitumour benzazoles." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283645.
Повний текст джерелаBrown, Stacy D., Andy Coop, Paul Trippier, and Eric Walters. "Contemporary Approaches For Teaching Medicinal Chemistry." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/5251.
Повний текст джерелаRazavet, Mathieu. "Synthetic {2Fe3S} assemblies and the active site of all-iron hydrogenases." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268566.
Повний текст джерелаWalton, Paul Howard. "The modelling of copper biosites." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276371.
Повний текст джерелаKamp, Norbert W. J. "The catalytic oxidation of phenolic substrates using manganese triazacyclononane complexes and hydrogen peroxide." Thesis, University of York, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265366.
Повний текст джерелаMars, Craig. "Small molecule models of nitrite reductase." Thesis, University of York, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270037.
Повний текст джерелаSchilter, David. "Synthesis and DNA-binding of Metallocyclic Architectures." Thesis, The University of Sydney, 2009. http://hdl.handle.net/2123/5317.
Повний текст джерелаSchilter, David. "Synthesis and DNA-binding of Metallocyclic Architectures." University of Sydney, 2009. http://hdl.handle.net/2123/5317.
Повний текст джерелаA new family of cationic N-heterocyclic ligand derivatives was prepared and characterised. Among these compounds are halide salts of the dications [Y(spacer)Y]2+, each of which comprise two N heterocyclic donor groups (Y = 4,4′-bipy, pyz, apyz, apym) linked by a conformationally flexible spacer such as (CH2)n, α,α′-xylylene, 2,6-lutidylene or thiabicyclo[3.3.1]nonane-2,6 diyl. The diquaternary halide salts were converted to NO3- and PF6- salts, and interaction of these bridging ligands with labile palladium(II) and platinum(II) precursors afforded several multinuclear complexes. Bis(4,4′-bipyridinium) dications were incorporated into the dinuclear macrocycles [M2(2,2′ bipy)2{4,4′ bipy(CH2)n4,4′-bipy}2]8+ (M = Pd, Pt; n = 4, 6), cis [Pd2Cl4{4,4′ bipy(CH2)34,4′-bipy}2]4+, [Pt2(dppp)2{4,4′-bipy(1,2-xylylene)4,4′-bipy}2]8+ and cis-[Pt2Cl4{4,4′-bipy(1,2-xylylene)4,4′-bipy}2]4+. While bis(pyrazinium) analogues were unreactive towards the palladium(II) and platinum(II) precursors, the doubly deprotonated bis(3 aminopyrazinium) and bis(2 aminopyrimidinium) derivatives served as charge-neutral quadruply-bridging ligands in the complexes [Pt4(2,2′ bipy)4{apyz(CH2)6apyz–2H}2]8+ and [Pt4(2,2′ bipy)4{apym(CH2)5apym–2H}2]8+, both of which feature Pt(II). Pt(II) interactions. Larger species formed when the diamine O,O′-bis(2-aminoethyl)octadeca(ethylene glycol) (PEGda) was treated with cis dinitratopalladium(II) and platinum(II) precursors. The resulting complexes [M(N,N)(PEGda)]2+ (M = Pd, Pt; N,N = 2,2′-bipy, en, tmeda) possessed great size (62 membered chelate rings) and aqueous solubility. DNA-binding studies were conducted with selected complexes in order to investigate the types of interactions these species might participate in. Equimolar mixtures containing either the 16mer duplex DNA D2 or the single strand D2a and palladium(II)/platinum(II) complexes were prepared and analysed by negative-ion ESI MS. Studies of D2/Pd(II) mixtures suggested extensive fragmentation was occuring, and the use of [Pd(tmeda)(PEGda)]2+ and [Pd2(2,2′-bipy)2{4,4′-bipy(CH2)44,4′-bipy}2]8+ resulted in D2 adducts of [Pd(tmeda)]2+ and [4,4′-bipy(CH2)44,4′-bipy]2+, respectively. Decomposition also occurred when D2a was used, although 1 : 1 adducts were observed with [Pd(tmeda)(PEGda)]2+, [Pd(2,2′ bipy)(PEGda)]2+ and [Pd2(2,2′-bipy)2{4,4′-bipy(CH2)44,4′-bipy}2]8+. The low intensities of these adducts indicated that they are unstable towards ESI MS. Analogous ESI-MS experiments using platinum(II) derivatives were performed and, in contrast to those with palladium(II), indicated that the complexes remained largely intact. ESI-MS analysis of D2/Pt(II) mixtures allowed for the detection of 1 : 1 D2 adducts of [Pt(en)(PEGda)]2+, [Pt(tmeda)(PEGda)]2+ and [Pt2(2,2′-bipy)2{4,4′-bipy(CH2)44,4′-bipy}2]8+. Intensities of the adduct ions suggested the greater charge and aryl surface area allow the dinuclear species to bind D2 most strongly. Both [Pt(2,2′-bipy)(Mebipy)2]4+ and [Pt(2,2′ bipy)(NH3)2]2+ gave rise to 1 : 2 adducts of D2, although the latter was found to be a weaker binder, perhaps owing to its lower charge. Data obtained using 1 : 5 (D2 : complex) mixtures were consistent with the results above and suggested that D2 can bind more molecules of daunomycin than any of the platinum(II) species. Analyses of D2a/Pt(II) mixtures gave results similar to those obtained with D2, although fragmentation was more pronounced, indicating that the nucleobases in D2a play more significant roles in mediating decomposition than those in D2, in which they are paired in a complementary manner. Investigations into the effects of selected platinum(II) complexes on the thermal denaturation of calf-thymus DNA (CT-DNA) in solution were conducted. Both [Pt2(2,2′ bipy)2{4,4′-bipy(CH2)64,4′-bipy}2]8+ and [Pt(2,2′-bipy)(Mebipy)2]4+ greatly stabilised CT-DNA, most likely by intercalation. In contrast, [Pt(tmeda)(PEGda)]2+ and [Pt(en)(PEGda)]2+ (as well as PEGda) caused negligible changes in melting temperature (∆Tm), suggesting that these interact weakly with CT-DNA. Data for [Pt(2,2′ bipy)(PEGda)]2+ and [Pt(2,2′-bipy)(NH3)2]2+ indicated that these species perhaps intercalate CT-DNA, with similar ∆Tm values for both complexes implying that PEGda does not play a major role in binding. While findings from ESI-MS experiments were similar to those from the thermal denaturation experiments, discrepancies between results from the two methods could be found. In particular, fragmentation of cyclic species during ESI-MS caused the binding strength of the species to be underestimated when this method was employed.
Golden, Melissa Lynn. "The bioinorganic chemistry of N2S2 metal complexes: reactivity and ligating ability." Diss., Texas A&M University, 2002. http://hdl.handle.net/1969.1/2198.
Повний текст джерелаJohannsen, Bernd, and S. Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Report January 1998 - Juni 1999." Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-30215.
Повний текст джерелаJohannsen, Bernd, and S. Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Report January 1998 - Juni 1999." Forschungszentrum Rossendorf, 1999. https://hzdr.qucosa.de/id/qucosa%3A21848.
Повний текст джерелаLyon, James Thomas III. "Chemical Studies on Oxomolybdenum(VI,IV) Complexes as Bioinorganic Models for the Molybdenum Oxidases." VCU Scholars Compass, 1985. https://scholarscompass.vcu.edu/etd/5227.
Повний текст джерелаRae, K. J. "The variation of some bioinorganic parameters in rheumatoid arthritis." Thesis, University of Strathclyde, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371978.
Повний текст джерелаAkay, Senol. "Diagnosis and Inhibition Tools in Medicinal Chemistry." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/chemistry_diss/41.
Повний текст джерела