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Статті в журналах з теми "Bioguided chemical study":
Schmitt, Marie, Abdulmagid Alabdul Magid, Jean-Marc Nuzillard, Jane Hubert, Nicolas Etique, Laurent Duca, and Laurence Voutquenne-Nazabadioko. "Investigation of Antioxidant and Elastase Inhibitory Activities of Geum urbanum Aerial Parts, Chemical Characterization of Extracts Guided by Chemical and Biological Assays." Natural Product Communications 15, no. 3 (March 1, 2020): 1934578X2091530. http://dx.doi.org/10.1177/1934578x20915307.
Hamion, Guillaume, Willy Aucher, Charles Tardif, Julie Miranda, Caroline Rouger, Christine Imbert, and Marion Girardot. "Valorization of Invasive Plant Extracts against the Bispecies Biofilm Staphylococcus aureus–Candida albicans by a Bioguided Molecular Networking Screening." Antibiotics 11, no. 11 (November 11, 2022): 1595. http://dx.doi.org/10.3390/antibiotics11111595.
Messaoudi, Radja, Abdelkrim Cheriti, and Younes Bourmita. "BIOASSAY-GUIDED ISOLATION OF THE MAJOR COMPOUND WITH ANTIOXIDANT ACTIVITY FROM THE ALGERIAN MEDICINAL PLANT BUBONIUM GRAVEOLENS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 11 (November 7, 2018): 424. http://dx.doi.org/10.22159/ajpcr.2018.v11i11.28514.
Joseph, Rhodin C., Matheus Silva da Fonseca Diniz, Viviane Magno do Nascimento, Abraão de Jesus Barbosa Muribeca, Johan Carlos Costa Santiago, Luziane da Cunha Borges, Paulo Roberto da Costa Sá, et al. "Secure and Sustainable Sourcing of Plant Tissues for the Exhaustive Exploration of Their Chemodiversity." Molecules 25, no. 24 (December 18, 2020): 5992. http://dx.doi.org/10.3390/molecules25245992.
Ismail, Amel, Leila Ktari, Yosr Ben Redjem Romdhane, Brahim Aoun, Saloua Sadok, Abdellatif Boudabous, and Monia El Bour. "Antimicrobial Fatty Acids from Green AlgaUlva rigida(Chlorophyta)." BioMed Research International 2018 (November 13, 2018): 1–12. http://dx.doi.org/10.1155/2018/3069595.
Ticona, Luis Apaza, Andreea Madalina Serban, Daly Apaza Ticona, and Karla Slowing. "Anti-inflammatory and Anti-arthritic Activities of Aqueous Extract and Flavonoids from Tripodanthus acutifolius Leaves in Mice Paw Oedema." Planta Medica International Open 8, no. 02 (May 27, 2021): e43-e55. http://dx.doi.org/10.1055/a-1471-8947.
Fechine, Ivana Maria, Karolayne da Silva Barbosa Alves, Renam Fellipe da Silveira Muniz, Caroline Leal Rodrigues Soares, Harley da Silva Alves, Teresinha Gonçalves da Silva, Carlos Arthur Gouveia Veloso, Micheline de Azevedo Lima, and Evelise Márcia Locatelli de Souza. "Evaluation of the cytotoxicity of products obtained from Calotropis procera (Apocynaceae)." Research, Society and Development 9, no. 12 (December 13, 2020): e4391210723. http://dx.doi.org/10.33448/rsd-v9i12.10723.
Yemoa, Achille, Joachim Gbenou, Dissou Affolabi, Mansourou Moudachirou, André Bigot, Séverin Anagonou, Françoise Portaels, Anandi Martin, and Joëlle Quetin-Leclercq. "Beninese Medicinal Plants as a Source of Antimycobacterial Agents: Bioguided Fractionation andIn VitroActivity of Alkaloids Isolated fromHolarrhena floribundaUsed in Traditional Treatment of Buruli Ulcer." BioMed Research International 2015 (2015): 1–5. http://dx.doi.org/10.1155/2015/835767.
Lima, Sandrine Maria Arruda, Pedro Silvino Pereira, Bruno Iraquitan Miranda da Silva, Natalie Emanuelle Ribeiro, Elizabeth Fernanda de Oliveira Borba, Cícera Datiane de Morais Oliveira Tintino, Karina Perrelli Randau, et al. "Antioxidant, antimicrobial and cytotoxic activities of secondary metabolites from Streptomyces sp. isolated of the Amazon-Brazil region." Research, Society and Development 10, no. 10 (August 14, 2021): e366101018974. http://dx.doi.org/10.33448/rsd-v10i10.18974.
FRAUSIN, G., R. B. S. LIMA, A. F. HIDALGO, L. C. MING, and A. M. POHLIT. "Plants of the Araceae family for malaria and related diseases: a review." Revista Brasileira de Plantas Medicinais 17, no. 4 (December 2015): 657–66. http://dx.doi.org/10.1590/1983-084x/14_024.
Дисертації з теми "Bioguided chemical study":
Montenegro, Tasso Gabriel Coelho. "Chemoenzymatic synthesis of chloramphenicol and thiamphenicol derivatives and bioguided chemical study of fungi associated with ascidian eudistoma vannamei." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7062.
Este trabalho descreve: 1) sÃntese quimioenzimÃtica de Ãsteres do cloranfenicol (1) e tianfenicol (2), utilizando lipases como fonte biocatalÃtica; 2) avaliaÃÃo do potencial atitumoral de fungos marinhos isolados da ascÃdia Eudistoma vannamei. Na primeira parte, realizou-se a sÃntese enzimÃtica de dois derivados monoacilados do cloranfenicol (1), atravÃs de reaÃÃes de hidrÃlise de derivados diacilados, e oito derivados monoacilados do tianfenicol (2), pela acilaÃÃo e hidrÃlise enzimÃtica do tianfenicol e derivados diacilados, respectivamente. Os seguintes parÃmetros foram variados: enzima, solvente, temperatura, pH e proporÃÃo entre solvente e agente hidrolÃtico e, na hidrÃlise enzimÃtica dos derivados de cloranfenicol diacilados, os melhores resultados foram com a mistura de CH3CN:tampÃo fosfato (pH 7) na proporÃÃo de 20:80, CAL-B como biocatalisador, temperatura de 20 ÂC, agitaÃÃo de 250 rpm e tempo reacional de 24 h. A reaÃÃo de acilaÃÃo enzimÃtica do tianfenicol (2), utilizando CAL-B como biocatalisador e Ãsteres vinÃlicos como doadores de grupos acila, se mostrou bastante eficiente, com altos Ãndices de conversÃo e seletividade. Os processos forneceram unicamente os produtos de acilaÃÃo da hidroxila menos impedida (3â-OH). A eficiÃncia da enzima CAL-B reciclada na reaÃÃo de acilaÃÃo do tianfenicol (2) foi investigada, sendo possÃvel concluir que esta se mantÃm ativa durante os cinco processos reacionais testados. A hidrÃlise enzimÃtica dos derivados diacilados do tianfenicol forneceu, majoritariamente, os produtos de hidrÃlise na posiÃÃo 3. Na segunda parte do trabalho, foram isoladas 11 cepas fÃngicas (EV1 a EV11) da ascÃdia E. vannamei, as quais foram cultivadas em meio lÃquido BD (batata-dextrose) com objetivo de realizar um estudo bioguiado atravÃs da avaliaÃÃo da atividade citotÃxica de seus extratos e fraÃÃes. Foram ensaiados os extratos acetoetÃlico do meio lÃquido e metanÃlico do micÃlio, previamente separados. Os extratos mais ativos foram os oriundos de EV10 e EV11, os quais foram identificados como Aspergillus sp. por anÃlise molecular. O fungo EV10 foi cultivado em grande escala para fracionamento bioguiado e isolamento dos metabÃlitos secundÃrios bioativos. Foi possÃvel isolar quatro micotoxinas: meleÃna, cis-4-hidroximeleÃna, trans-4-hidroximeleÃna e Ãcido penicÃlico, dentre as quais, somente o Ãcido penicÃlico foi identificado como responsÃvel pela atividade do extrato.
This work describes: 1) chemoenzymatic synthesis of chloramphenicol (1) and thiamphenicol (2) esters, using lipases as biocatalyst source; 2) investigation of the antitumor potential of fungi isolated from the marine ascidian Eudistoma vannamei. In the first part, it was carried out the enzymatic synthesis of two monoacyl derivatives of chloramphenicol (1), through the hydrolysis of the diacyl derivatives, and eight monoacyl derivatives of thiamphenicol (2), by the enzymatic acylation and hydrolysis of thiamphenicol and diacyl derivatives, respectively. The following p arameters were varied: enzyme, solvent, temperature, pH and proportion between solvent and agent hydrolytic, and in enzymatic hydrolysis of the diacyl derivatives of chloramphenicol, the best results were reached when using a mixture of CH3CN: phosphate buffer (pH 7) in the proportion 20:80, CAL-B as biocatalyst, temperature of 20 Â C, 250 rpm and reaction time of 24 h. The enzymatic acylation of thiamphenicol (2), using CAL-B as biocatalyst and vinyl esters as acyl donor groups, was very efficient, with high conversion and selectivity. The processes provided only products of the ac ylation of the less hindered hydroxyl group (3'-OH). The efficiency of the recycled CAL-B in the acylation of thiamphenicol (2) was investigated, being possible to conclude that its activity was maintained during the five tested reactions. Enzymatic hydrolysis of diacylated derivatives of thiamphenicol, provided mostly the hydrolysis products in position 3. In the second part of this work, we isolated 11 fungal strains (EV1 to EV11) associated to the ascidian E. vannamei, which were cultivated in liquid BD (potato dextrose) in order to conduct a bioguided study by evaluating the cytotoxic activity of their extracts and fractions. The ethylacetate extracts of the liquid medium and methanol extracts from the mycelium, previously separate, were assayed and the most active extracts were those from EV10 and EV11, which were identified as Aspergillus sp. by molecular analysis. EV10 was grown on a larger scale allowing the bioguided fractionation and isolation of bioactive secondary metabolites. It was possible to isolate four mycotoxins: mellein, cis-4-hydroxymellein, trans-4-hydroxymellein and penicillic acid, among which only the later compound was identified as responsible for the activity of the extract.
Ouattara, Nangouban. "Etude phytochimique et biologique des plantes médicinales antimicrobiennes de Côte d’Ivoire pour une valorisation thérapeutique contre Toxoplasma gondii et Candida auris." Electronic Thesis or Diss., Reims, 2023. http://www.theses.fr/2023REIMS059.
This work presents a bioguided phytochemical study of nine Ivorian plants pre-selected for their potential antiparasitic and/or fungicidal activity: Combretum micranthum G. Don (Combretaceae), Elaeis guineensis Jacq. (Arecaceae), Erigeron floribundus Kunth Sch.Bip (Asteraceae), Oldfieldia africana Benth. & Hook. f. (Euphorbiaceae), Octoknema borealis Hutch. & Dalziel (Olacaceae), Omphalocarpum ahia A. Chev (Sapotaceae), Omphalocarpum elatum Miers (Sapotaceae), Tristemma coronatum Benth (Melastomataceae) and Tristemma spp (Melastomataceae).Sequential extractions yielded forty-four crude extracts, which were then screened in vitro at 25 µg/ml against Toxoplasma gondii. Thirty-seven extracts were found to be non-cytotoxic against Vero cells, and ten of these inhibited parasite growth by more than 50%. On the other hand, screening of these forty-four extracts revealed that five of them inhibited more than 50% of the growth of Candida auris and other yeast strains.Three extracts that inhibited more than 90% of parasite growth were selected for the identification of the compounds present, responsible for the activity against T. gondii: the Dichloromethane extract of the bark of the trunk and the AcOEt extract of the leaves of Omphalocarpum ahia; and the hydromethanolic extract of the leaves of E. guineensis.The work carried out on the barks and leaves of O. ahia led mainly to the discovery of triterpenes, including eight new ones, for which chemosensitivity tests were carried out. This showed that an ursan-type triterpene strongly inhibits the growth of toxoplasma, while being highly selective to it. The selectivity index and IC50 allowed us to discuss the structure-activity relationship (SAR) between the isolated triterpenes. The biological target on toxoplasma was sought by reverse docking, and the results indicated that certain bioactive triterpenes form different complexes with the DNA-binding protein of the histone family, the protein containing the SET domain and the protein containing the pH domain of toxoplasma.Bioguided fractionation of the hydromethanolic extract of E. guineensis leaves did not reveal any antitoxoplasmic activity. Purification of the fractions enabled us to characterise triterpenes, sesquiterpenes (including three new ones), polyphenols (including one new one), flavonoids and alkaloids that are potentially responsible for the masked antitoxoplasmic activity.The AcOEt extract of Octoknema borealis trunk bark was the only one to show antifungal activity against all yeasts (MIC = 25 µg/ml) and over 70% to 90% growth inhibition of C. auris and other yeasts. This AcOEt extract was fractionated by CPC, and antifungal activity was found in the majority of its fractions. The chemical profiling of these fractions was carried out by 13C NMR dereplication (CaraMel) and enabled us to identify the metabolites responsible for this strong fungicidal activity