Дисертації з теми "Biodegradable polymeric nanoparticles"
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Jo, Ami. "The Design of Biodegradable Polyester Nanocarriers for Image-guided Therapeutic Delivery." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/97220.
Повний текст джерелаPh. D.
Heffernan, Michael John. "Biodegradable polymeric delivery systems for protein subunit vaccines." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24787.
Повний текст джерелаCommittee Chair: Dr. Niren Murthy; Committee Member: Dr. Carson Meredith; Committee Member: Dr. Julia Babensee; Committee Member: Dr. Mark Prausnitz; Committee Member: Dr. Ravi Bellamkonda.
COLOMBO, FEDERICO. "Innovative approach for the treatment and the diagnosis of rheumatoid arthritis exploiting polymeric biodegradable nanoparticles targeting synovial endothelium." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2917682.
Повний текст джерелаCella, C. "Development of biodegradable nanoparticles for targeting Tumor Associated Macrophages: synthesis, investigation of the role of the surfactant and surface decoration in complex media." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/366594.
Повний текст джерелаYilgor, Pinar. "Sequential Growth Factor Delivery From Polymeric Scaffolds For Bone Tissue Engineering." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12611188/index.pdf.
Повний текст джерелаhowever, the control of the cell organization and cell behavior to create fully functional 3-D constructs has not yet been achieved. To overcome these, activities have been concentrated on the development of multi-functional tissue engineering scaffolds capable of delivering the required bioactive agents to initiate and control cellular activities. The aim of this study was to prepare tissue engineered constructs composed of polymeric scaffolds seeded with mesenchymal stem cells (MSCs) carrying a nanoparticulate growth factor delivery system that would sequentially deliver the growth factors in order to mimic the natural bone healing process. To achieve this, BMP-2 and BMP-7, the osteogenic growth factors, were encapsulated in different polymeric nanocapsules (poly(lactic acid-co-glycolic acid) (PLGA) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)) with different properties (degradation rates, crystallinity) and, therefore, different release rates to achieve the early release of BMP-2 followed by the release of BMP-7, as it is in nature. Initially, these nanoparticulate delivery systems were characterized and then the effect of single, simultaneous and sequential delivery of BMP-2 and BMP-7 from these delivery systems was studied in vitro using rat bone marrow MSCs. The effect of using these two growth factors in a sequential manner by mimicking their natural bioavailability timing was shown with maximized osteogenic activity results. BMP-2 loaded PLGA nanocapsules were subcutaneously implanted into Wistar rats and according to initial results, their biocompatibility as well as the positive effect of BMP-2 release on the formation of osteoclast-like cells was shown. To complete the construction of the bioactive scaffold, this nanoparticulate sequential delivery system was incorporated into two different types of polymeric systems
natural (chitosan) and synthetic (poly(&
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-caprolactone) (PCL)). 3-D fibrous scaffolds were produced using these materials by wet spinning and 3-D plotting. Incorporation of nanocapsules into 3-D chitosan scaffolds was studied by two different methods: incorporation within and onto chitosan fibers. Incorporation into 3-D PCL scaffolds was achieved by coating the nanocapsules onto the fibers of the scaffolds in an alginate layer. With both scaffold systems, incorporation of nanocapsule populations capable of delivering BMP-2 and BMP-7 in single, simultaneous and sequential fashion was achieved. As with free nanocapsules, the positive effect of sequential delivery on the osteogenic differentiation of MSCs was shown with both scaffold systems, creating multi-functional scaffolds capable of inducing bone healing.
Quintanar-Guerrero, David. "Étude de nouvelles techniques d'obtention de suspensions de nanoparticules à partir de polymères préformés." Lyon 1, 1997. http://www.theses.fr/1997LYO1T270.
Повний текст джерелаKaur, Jasmeet. "Properties of biologically relevant nanocomposites: effects of calcium phosphate nanoparticle attributes and biodegradable polymer morphology." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/33981.
Повний текст джерелаLi, Yonghui. "Biodegradable poly(lactic acid) nanocomposites: synthesis and characterization." Diss., Kansas State University, 2011. http://hdl.handle.net/2097/8543.
Повний текст джерелаDepartment of Grain Science and Industry
X. Susan Sun
Biobased polymers derived from renewable resources are increasingly important due to acute concerns about the environmental issues and limited petroleum resources. Poly(lactic acid) (PLA) is such a polymer that has shown great potential to produce biodegradable plastics. However, low glass transition temperature (Tg), low thermal stability, slow biodegradation rate, and high cost limit its broad applications. This dissertation seeks to overcome these limitations by reinforcing PLA with inorganic nanoparticles and low-cost agricultural residues. We first synthesized PLA nanocomposites by in situ melt polycondensation of L-lactic acid and surface-hydroxylized nanoparticles (MgO nanocrystals and TiO2 nanowires) and investigated the structure-property relationships. PLA grafted nanoparticles (PLA-g-MgO, PLA-g-TiO2) were isolated from the bulk nanocomposites via repeated dispersion/centrifugation processes. The covalent grafting of PLA chains onto nanoparticle surface was confirmed by Fourier transform infrared spectroscopy and thermalgravimetric analysis (TGA). Transmission electron microscopy and differential scanning calorimetry (DSC) results also sustained the presence of the third phase. Morphological images showed uniform dispersion of nanoparticles in the PLA matrix and demonstrated a strong interfacial interaction between them. Calculation based on TGA revealed that more than 42.5% PLA was successfully grafted into PLA-g-MgO and more than 30% was grafted into PLA-g-TiO2. Those grafted PLA chains exhibited significantly increased thermal stability. The Tg of PLA-g-TiO2 was improved by 7 °C compared with that of pure PLA. We also reinforced PLA with low-value agricultural residues, including wood flour (WF), soy flour (SF), and distillers dried grains with solubles (DDGS) by thermal blending. Tensile measurements and morphological images indicated that methylene diphenyl diisocyanate (MDI) was an effective coupling agent for PLA/WF and PLA/DDGS systems. MDI compatibilized PLA/WF and PLA/DDGS composites showed comparable tensile strength and elongation at break as pure PLA, with obviously increased Young’s modulus. Increased crystallinity was observed for PLA composites with SF and DDGS. Such PLA composites have similar or superior properties compared with pure PLA, especially at a lower cost and higher biodegradation rate than pure PLA. The results from this study are promising. These novel PLA thermoplastic composites with enhanced properties have potential for many applications, such as packaging materials, textiles, appliance components, autoparts, and medical implants.
Nastiti, Christofori Maria Ratna Rini. "Development and evaluation of polymeric nanoparticle formulations for triamcinolone acetonide delivery." Thesis, Curtin University, 2007. http://hdl.handle.net/20.500.11937/613.
Повний текст джерелаHawkins, Ashley Marie. "BIODEGRADABLE HYDROGELS AND NANOCOMPOSITE POLYMERS: SYNTHESIS AND CHARACTERIZATION FOR BIOMEDICAL APPLICATIONS." UKnowledge, 2012. http://uknowledge.uky.edu/cme_etds/10.
Повний текст джерелаPancani, Elisabetta. "Development and advanced characterisation of antibiotic-loaded nanoparticles to fight intracellular bacteria." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS513/document.
Повний текст джерелаThe treatment of intracellular infections is very challenging given the ability of bacteria to “hide” inside the cells of the host, especially the ones of the immune system, thus hampering the action of many antimicrobial agents. The battle against these bacteria has been further exacerbated by the increasing diffusion of antimicrobial resistant strains. In this frame, nanoparticles (NPs) are a very promising strategy to overcome the limitations of free antimicrobial agents by administering them in an optimized manner.This PhD work, performed as part of the European Project ITN Cyclon Hit, aimed at the development and advanced characterisation of antibiotic-loaded biodegradable and biocompatible NPs made of poly (lactic acid) (PLA), poly (lactic-co-glycolic) (PLGA) and polycaprolactone (PCL) or of polymerised cyclodextrins (pCDs).The first two chapters are dedicated to the encapsulation of powerful but challenging drugs in polymeric NPs. Firstly, these carriers were employed for the simultaneous delivery of a potent drug combination recently discovered, ethionamide (ETH) and its booster, for tuberculosis therapy. Secondly, they were used to address the challenges related to the incorporation of a first-generation quinolone, pipemidic acid (PIP), with the aim of optimising its intracellular delivery in infections such as salmonellosis.The efficient co-incorporation of ETH and booster had to overcome several technological barriers. These drugs presented solubility, crystallisation and bioavailability-related problems which were overcome thanks to the developed NPs. Our engineered PLA and pCD NPs were both able to efficiently co-encapsulate the two molecules. Among the in depth-characterised formulations, pCDs NPs displayed the best physico-chemical properties and were shown to host the drugs both in the CD cavities and in confined spaces inside NPs crosslinked polymer. The pCD NPs were administered in vivo by endotracheal route directly to the infection site. Empty NPs were shown non-toxic after repeated pulmonary administration of high doses. Moreover, loaded pCD NPs led to a 3-log decrease in the pulmonary bacterial load of infected animals after only 6 administrations. Similarly, the incorporation of PIP faced challenges mainly related to PIP crystallization and burst release. Unfortunately, PIP displayed poor affinity for all the studied polymeric materials and its physical encapsulation was unsuccessful. Thus, an alternative approach was developed by coupling PIP to PCL by using an original catalyst-free drug-initiated reaction. The PCL-PIP conjugate self-assembled in NPs with up to 27 wt% PIP which were thoroughly characterised. However, the conjugate couldn’t be enzymatically degraded. With the design of novel PCL-PIP conjugates, this self-assembly approach could represent a promising strategy.The deep understanding of the structure and composition of complex core-corona nanocarriers containing one or two active molecules is crucial for their optimisation. The last two chapters are devoted to the innovative application of AFM-IR, an original nanospectroscopic method combining atomic force microscopy (AFM) with infrared (IR) spectroscopy, to the chemical analysis of PLGA NPs or to their label-free detection after cell internalisation.AFM-IR is able to provide chemical characterisation at the nanometer scale (resolution ~10nm). One main breakthrough here is the application of the recently developed tapping mode allowing the investigation of single polymeric NPs. The specific IR signal of NPs constituents was used to unravel the chemical composition of their core and corona as well as to precisely locate the drug. Moreover, the AFM-IR in contact mode enabled for the first time the label-free localisation and unambiguous chemical identification of NPs inside cells using the polymer IR specific response as a fingerprint. This work paves the way for countless application of this technique in the field of drug delivery
Robishaw, Nikki K. "Encapsulating N-heterocyclic carbene complexes into biodegradable nanoparticles and the antimicrobial and antitumor effects." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1530222031725709.
Повний текст джерелаSeif, Sylvain S. "Temporally Programmed Stretching of Polymer Films: Influence of Nanoparticles." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1248047899.
Повний текст джерелаCano, Embuena Amalia Isabel. "Different strategies to improve the functionality of biodegradable films based on starch and other polymers." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/55383.
Повний текст джерела[ES] En la Tesis Doctoral, se han analizado diferentes estrategias para mejorar las propiedades funcionales de películas de almidón para aplicaciones de envasado de alimentos: el estudio del ratio amilosa:amilopectina, mezclas con otros polímeros (alcohol de polivinilo-PVA), y la incorporación de diferentes refuerzos (salvado de arroz y nanocristales de celulose-CNCs) y agentes antimicrobianos (aceite de neem-N, aceite esencial de orégano-O y nanopartículas de plata-AgNPs). También se realizó un estudio de biodegradación de las películas observando el efecto de los antimicrobianos. Entre los diferentes almidones con distinto ratio amilosa:amilopectina, se seleccionó el almidón de guisante con altos valores de amilosa. El alto contenido en amilosa dio lugar a películas más rígidas y resistentes a la fractura, con baja permeabilidad al oxígeno, la cual disminuyó durante el almacenamiento. Las películas de mezcla de almidón-PVA (S-PVA) representaron una buena estrategia para mejorar las propiedades de las películas sin incrementar notablemente el precio. La adición de PVA dio lugar a películas menos solubles en agua, menos sensibles a su absorción y más extensible y resistentes que las de almidón puro, mientras mantuvieron alta barrera al oxígeno y dieron estabilidad a la matriz durante el envejecimiento. Son recomendables los ratios de S-PVA cercanos a 1:1. El salvado de arroz con menor tamaño de partícula, mejoró el modulo elástico de las películas, pero su extensibilidad y propiedades barrera empeoraron debido a la mejor capacidad de retención de agua y a las discontinuidades introducidas. La incorporación de CNCs en las películas de S-PVA incrementó la separación de fases de los polímeros, sin cambios en la permeabilidad al vapor de agua, y mejoró las prestaciones mecánicas: películas más rígidas y extensibles, mientras que inhibió parcialmente la cristalización del PVA. Las películas de S-PVA con partículas de plata exhibieron actividad antimicrobiana contra dos hongos y dos bacterias, dependiendo de la concentración de plata. Las AgNPs provocaron cambios en el color de las películas así como en su transparencia. La plata fue completamente liberada en los primeros 60 minutos en contacto con simulantes acuosos, sin embargo la liberación disminuyó en simulantes no polares, donde se cumple el límite de migración global. Por lo tanto, el uso de las películas desarrolladas para envasado de alimentos debe ser restringido a productos alimenticios ricos en grasas. La incorporación de O en la matriz de S-PVA dio lugar a películas activas contra bacterias y hongos, mientras que las películas con N no fueron efectivas. Se necesitaron concentraciones más altas de O en las películas para observar un efecto antifúngico respecto a la actividad bactericida. Los aceites no afectaron notablemente la sensibilidad ni las propiedades barreras al agua de las películas, aunque la mayor proporción de aceite dio lugar a películas con una red más débil, afectando sus prestaciones mecánicas. La mezcla de S con PVA mejoró significativamente el comportamiento de biodegradación y desintegración de las películas. La incorporación de AgNPs a películas de S-PVA disminuyó su cinética de biodegradación mientras aumentó su ratio de degradación. La adición de O no presentó efecto significativo en el índice de biodegradación a pesar de la actividad antimicrobiana detectada. El N incluso mejoró la biodegradación de las películas. Finalmente, se realizó una aplicación de recubrimientos basados en biopolímeros, usando quitosano-CH y aceite esencial de orégano o romero para evitar la pérdida de peso y el desarrollo de hongos en quesos de cabra semicurados. Los recubrimientos fueron efectivos en la reducción del crecimiento fúngico y la pérdida de peso de los quesos, mientras que la actividad lipolítica y proteolítica ligeramente disminuyó. El análisis sensorial reveló q
[CAT] S'han analitzat diferents estratègies per a millorar les propietats funcionals de pel·lícules de midó per a aplicacions d'envasat d'aliments: l'estudi de la ràtio amilosa:amilopectina, mescles amb altres polímers (alcohol polivinílic-PVA), i la incorporació de diferents reforços (segó d'arròs i nanocristalls de celulosa-CNCs) i agents antimicrobians (oli de neem-N, oli essencial d'orenga-O i nanopartícules de plata). També es va fer un estudi de biodegradació de les pel·lícules per observar l'efecte dels antimicrobians. Entre els diferents midons amb distint ràtio amilosa:amilopectina, es va seleccionar el midó de pèsol amb alts valors d'amilosa. L'alt contingut en amilosa va donar lloc a pel·lícules més rígides i resistents a la fractura, amb baixa permeabilitat a l'oxigen, la qual va disminuir durant l'emmagatzemament. Les pel·lícules de mescla de S-PVA van representar una bona estratègia per a millorar les propietats de les pel·lícules sense incrementar notablement el preu. L'addició de PVA va donar lloc a pel·lícules menys solubles en aigua, menys sensibles a la seua absorció i més extensible i resistents que les de midó pur. A més van mantenir l'alta barrera a l'oxigen i van donar estabilitat a la matriu durant l'envelliment. Son recomanables les ràtios de S- PVA pròxims a 1:1. El segó d'arròs amb menor tamany de partícula, va millorar el mòdul elàstic de les pel·lícules, però la seua extensibilitat i propietats barrera van empitjorar. La incorporació de CNCs en les pel·lícules de S-PVA, va incrementar la separació de fases dels polímers, sense implicar canvis en la permeabilitat al vapor d'aigua, però millorant les prestacions mecàniques: pel·lícules més rígides i extensibles, al mateix temps que es va inhibir parcialment la cristal·lització del PVA. Les pel·lícules de S-PVA amb partícules de plata van exhibir activitat antimicrobiana front a dos de fongs i dos bacteris, depenent de la concentració de plata. Les AgNPs van provocar canvis en el color de les pel·lícules així com en la seua transparència. La plata va ser completament alliberada en els primers 60 minuts en contacte amb simulants aquosos. La capacitat d'alliberament va disminuir en simulants no polars, on es complix el límit de migració global. Per tant, l'ús de les pel·lícules desenvolupades per a l'envasat d'aliments ha de ser restringit a productes alimentaris rics en greixos. La incorporació d'O en la matriu de S-PVA va donar lloc a pel·lícules actives front a bacteris i fongs. Pel contrari les pel·lícules amb N no van ser efectives. Van ser necessàries concentracions més elevades d'O en les pel·lícules per a observar un efecte antifúngic respecte a l'activitat bactericida. Els olis no van afectar la sensibilitat a l'aigua ni les propietats barrera a l'aigua de les pel·lícules, però la major proporció d'oli va donar lloc a pel·lícules amb una xarxa més dèbil, afectant les seues prestacions mecàniques. La mescla de S amb PVA va millorar significativament el comportament de biodegradació i desintegració. La incorporació de partícules de plata a pel·lícules de S-PVA va disminuir la seua cinètica de biodegradació mentre que va augmentar la seua ràtio de degradació. No obstant això, l'addició d'O no va presentar un efecte significatiu en els índexs de biodegradació a pesar de l'activitat antimicrobiana detectada. L'N fins i tot va millorar la biodegradació de les pel·lícules de S-PVA. Finalment, es va realitzar una aplicació de recobriments basats en biopolímers, fent ús de quistosà-CH i olis essencials de orenga i romer per evitar la pèrdua de pes i el desenvolupament de fongs en formatges de cabra semi-curats. Els recobriments van ser altament efectius en la reducció del creixement fúngic i la pèrdua de pes dels formatges. L'activitat lipolítica i proteolítica en els formatges va disminuir suaument. L'anàlisi sensorial va revelar que els form
Cano Embuena, AI. (2015). Different strategies to improve the functionality of biodegradable films based on starch and other polymers [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/55383
TESIS
Premiado
Pillai, Jonathan Devasitham. "Biodegradable Polymer Constructs for Disease-specific, Localized and Sustained Drug Delivery of a Novel Synthetic Curcumin Analog." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1217548715.
Повний текст джерелаMIGLIORINI, LORENZO. "DEVELOPMENT OF FUNCTIONAL NANOCOMPOSITE MATERIALS TOWARDS BIODEGRADABLE SOFT ROBOTICS AND FLEXIBLE ELECTRONICS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/704286.
Повний текст джерелаLetchford, Kevin John. "Development of methoxy poly(ethylene glycol)-block-poly(caprolactone) amphiphilic diblock copolymer nanoparticulate formulations for the delivery of paclitaxel." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2487.
Повний текст джерелаLong, Wei. "Designing immobilized catalysts for chemical transformations: new platforms to tune the accessibility of active sites." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/49017.
Повний текст джерелаŠkodová, Michaela. "Polymerní nanočástice s biodegradovatelným jádrem a chelatující polymery pro medicínské účely." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-322601.
Повний текст джерелаFu, Ying-Hwa, and 傅映樺. "Biodegradable Polymeric Nanoparticles Disassemble in Response to Hydrogen Peroxide and Lipase with Fluorescence Ratiometric Readout." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/09326309596225319552.
Повний текст джерела國立臺灣大學
化學研究所
101
Amphiphilic block polycarbonates have received significant attention in designing a variety of therapeutics and diagnosis owing to their biocompatibility, and tunable mechanical properties. Herein we demonstrate a biodegradable amphiphilic polycarbonate (MTC-MPA-3HF) bearing ROS-reactive pendent groups as a new biomaterial to sense ROS in physiological environment. Before the treatment of stimuli, MTC-MPA-3HF assembles into a stable nanoparticle in aqueous solution resulting ESIPT-dominated green fluorescence in hydrophobic milieu, whereas MTC-MPA-3HF may disassemble upon the treatment of ozone- or hydrogen peroxide emitting ESICT-dominated blue fluorescence (Figure A). Correspondingly, two polymeric structures decorating with different reactive triggers in more hydrophobic block to sense ozone and hydrogen peroxide were designed and synthesized. O3-responsive polymer (MTC-MPA-3HF-O3) employs MTC-Obutene to serve as the ozone-reactive moiety as well as to confer the required hydrophobicity, while H2O2-responsive polymer (MTC-MPA-3HF-H2O2) having MTC-O3dCHBE or MTC-OArBE to serve as the H2O2-reactive group (Figure B). Both polymers feature the same hydrophilic unit, MTC-OmDEG, and the environmentally-sensitive bis-MPA-3HF fluorophore as an initiator. The fluorescence behaviors and the morphology of the particles were studied by fluorescence spectroscopy and transmission electron microscope, respectively, before and after the treatment of stimuli. The results showed that in the case of MTC-MPA-3HF-O3, ozone seems to react with bis-MPA-3HF much faster than MTC-Obutene resulting in fluorescence quenching without manifesting size change. However, MTC-MPA-3HF-O3 displayed an excellent specificity to the lipase from Candida Antarctica. Either the skeleton or the pendent of the polymer was presumably hydrolyzed to give the fluorescence color change, rendering the application of MTC-MPA-3HF-O3 in antibacterial therapy quite feasible. In the case of MTC-MPA-3HF-H2O2 with alkyl boronic ester, nanoparticles became 500-fold larger with ratiometric fluorescence readout upon reacting with hydrogen peroxide. It is worthwhile to note that replacing alkyl boronic ester with aryl boronic ester gave even better ratiometric fluorescence signals. In conclusion, we have successfully developed a series of biodegradable amphiphilic polycarbonates bearing ozone- or hydrogen peroxide-reactive groups that may disassemble upon exposure to each targeted stimuli with concomitant fluorescence color change. Furthermore, taking advantages of ester-rich MTC-MPA-3HF, it is feasible to detect the bacterial lipase by monitoring the ratiometric fluorescent readout. These materials can be potentially used in delivering therapeutics or serve as diagnostic agents.
Yu, Shi, and Gan-Moog Chow. "Synthesis and Characterization of a Magnetically Responsive Polymeric Drug Delivery System." 2003. http://hdl.handle.net/1721.1/3795.
Повний текст джерелаSingapore-MIT Alliance (SMA)
King, S. L., V. X. Truong, C. Kirchhoefer, Anaïs Pitto-Barry, and A. P. Dove. "Synthetic strategies, sustainability and biological applications of malic acid-based polymers." 2014. http://hdl.handle.net/10454/15343.
Повний текст джерелаThis review summarises the recent developments in the synthesis and applications of polymers derived from malic acid. There has been an increased interest in the design of sustainable and biodegradable polymers as a result of the drive to use renewable feedstocks as an alternative to petrochemicals in addition to their significant potential in biomedical applications. Synthetic strategies to access polymers from malic acid based on both condensation and ring-opening polymerization, across a broad range of conditions, are reviewed along with their advantages and limits. The role that such materials are studied for in biomedical applications is discussed, and their environmental impact based on the biodegradability of the malic polymer backbone is outlined.
The Royal Society, EPSRC, BBSRC
Staňková, Petra. "Farmaceutické aplikace polyesterů jako nanonosičů léčiv." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-382764.
Повний текст джерелаBacskaiová, Silvia. "Příprava biodegradovatelných polymerních nanočástic." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-388093.
Повний текст джерелаCai, Cuifang [Verfasser]. "Biodegradable polymer micro- and nanoparticles as protein delivery systems : influence of microparticle morphology and improvement of protein loading capacity of nanoparticles / vorgelegt von Cuifang Cai." 2007. http://d-nb.info/985950331/34.
Повний текст джерелаBárta, Michal. "Příprava polymerních farmaceutických nanočástic: optimalizace procesu." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-382798.
Повний текст джерелаJäger, Eliézer. "Srovnání polymerních nanoléčiv odpovídajících a neodpovídajících na vnější podněty pro biomedicinální aplikace." Doctoral thesis, 2015. http://www.nusl.cz/ntk/nusl-350097.
Повний текст джерела