Дисертації з теми "Biochemistry and Cell Biology N.E.C"
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Buchanan, Fritz G. "Endogenous Alkylglycerol Functions As a Mediator of Protein Kinase C Activity and Cell Proliferation." Digital Commons @ East Tennessee State University, 1997. https://dc.etsu.edu/etd/2885.
Повний текст джерелаWilliams, Kendra Allana. "Phosphorylation of Histone Deacetylase 6 within its C-terminal Region by Extracellular Signal Regulated Kinase 1." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4792.
Повний текст джерелаGu, Cong. "Superoxide Dismutase C Modulates Macropinocytosis and Phagocytosis in Dictyostelium Discoideum." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3887.
Повний текст джерелаUnsworth, Amanda J. "The role of protein kinase C in platelet activation." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:114582b8-185a-41f5-958c-77038fb185df.
Повний текст джерелаHiyama, Jun. "Isolation and characterisation of N-glycans of ovine and human luteinizing hormones." Thesis, University of Auckland, 1991. http://hdl.handle.net/2292/1989.
Повний текст джерелаLumngwena, Evelyn Ngwa. "The impact of HIV-1 subtype C Envelope N-glycosylation on DC-SIGN meditated modulation of DC function to facilitate transmission or enhance viral pathogenesis." Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/27096.
Повний текст джерелаDagälv, Anders. "Role of Heparan Sulfate N-sulfation in Mouse Embryonic Development." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-123474.
Повний текст джерелаde, Jesus Tristan J. "Novel Mechanisms of Immune Regulation by NF-kappaB c-Rel." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1576176282590614.
Повний текст джерелаGiblin, Sean. "Investigating cell lineage specific biosynthesis of tenascin-C during inflammation." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:8c7306d8-53cf-4131-a134-f74885e37cc9.
Повний текст джерелаSmith, Abigail O. "Defining the Role of c-Jun N-terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1141.
Повний текст джерелаDesai, Shraddha R. "Role of Protein Kinase C-iota in Glioblastoma." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3070.
Повний текст джерелаPillai, Prajit P. "Role of Protein Kinase C-iota in Neuroblastoma and the Effect of ICA-1, a Novel Protein Kinase C-iota Inhibitor on the Proliferation and Apoptosis of Neuroblastoma Cells." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3292.
Повний текст джерелаJohnston, Alyssa N. "A Ternary Drug Delivery Complex to Target CD44 Over Expressing Cancerous Cell Lines." Kent State University Honors College / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1335737666.
Повний текст джерелаFarley, Brian M. "Sequence and Target Specificity of the C. elegans Cell Fate Specification Factor POS-1: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/629.
Повний текст джерелаSutherland, Ashley B. "Fabrication of Responsive Polymer Brushes for Patterned Cell Growth and Detachment." Wright State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1376981495.
Повний текст джерелаAnderson, Ryan L. "Fatty Acid Amides and Their Biosynthetic Enzymes Found in Insect Model Systems." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7467.
Повний текст джерелаBarnard, Sandra H. "Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis." UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/20.
Повний текст джерелаPeters, Jeffery. "Effects of Nicotinamide Riboside and Beta-hydroxybutyrate on C. elegans Lifespan." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/honors/531.
Повний текст джерелаDahl, Göran. "Kinetic studies of NS3 and NS5B from Hepatitis C virus : Implications and applications for drug discovery." Doctoral thesis, Uppsala universitet, Institutionen för biokemi och organisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98868.
Повний текст джерелаWu, Sijia. "Novel Mechanisms Regulating Dopamine Transporter Endocytic Trafficking: Ack1-Controlled Endocytosis And Retromer-Mediated Recycling." eScholarship@UMMS, 2001. http://escholarship.umassmed.edu/gsbs_diss/887.
Повний текст джерелаWu, Sijia. "Novel Mechanisms Regulating Dopamine Transporter Endocytic Trafficking: Ack1-Controlled Endocytosis And Retromer-Mediated Recycling." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/887.
Повний текст джерелаGao, Xin D. "Combining CRISPR-Cas9 and Proximity Labeling to Illuminate Chromatin Composition, Organization, and Regulation." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1053.
Повний текст джерелаFagan, Rita R. "Rit2-Dependent Dopamine Transporter Endocytosis: Intrinsic Mechanism and In Vivo Impact." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1086.
Повний текст джерелаCarr, Michael I. "The Role of MDM2 Phosphorylation in P53 Responses to DNA Damage and Tumor Suppression: A Dissertation." eScholarship@UMMS, 2016. http://escholarship.umassmed.edu/gsbs_diss/847.
Повний текст джерелаHaines, Ricci. "The Role of Argininosuccinate Synthase Serine 328 Phosphorylation in Nitric Oxide Production." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4061.
Повний текст джерелаGruber, Claudia. "Investigation into the regulatory mechanism of BRCA2 stability." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:e69ab649-f955-48d2-a7c5-48b65f15df45.
Повний текст джерелаPeterneva, Ksenia. "Determining the mechanism of pathogenesis of mucolipidosis type IV and related lysosomal storage disorders for development of novel therapies." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:321b1da6-0033-4230-b047-b643e5ea3e60.
Повний текст джерелаHu, Yu-Jie. "Roles of Protein Arginine Methyltransferase 7 and Jumonji Domain-Containing Protein 6 in Adipocyte Differentiation: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/797.
Повний текст джерелаHu, Yu-Jie. "Roles of Protein Arginine Methyltransferase 7 and Jumonji Domain-Containing Protein 6 in Adipocyte Differentiation: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/797.
Повний текст джерелаFogeron, Marie-Laure. "Development of a wheat germ cell-free expression system for the production, the purification and the structural and functional characterization of eukaryotic membrane proteins : application to the preparation of hepatitis C viral proteins." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10081/document.
Повний текст джерелаWhile 30% of the genome encodes for membrane proteins, less than 3% of protein structures in the Protein Data Bank correspond to such proteins. Due to their hydrophobic nature, membrane proteins are indeed notoriously difficult to express in classical cell-based protein expression systems. The structural study of the membrane proteins of hepatitis C virus (HCV) in their full-length and native form has therefore been for long time hampered. HCV is a positive-strand RNA virus building its replication complex on a specific membrane rearrangement (membranous web), which serves as a scaffold for the HCV replicase, and is induced by the concerted action of several HCV non-structural proteins including NS2, NS4B and NSSA. The knowledge of the three- dimensional structure of these proteins and their role in virus replication is still limited. To overcome the limitations that prevent the structural and functional studies of these proteins, a wheat germ cell-free protein expression system has been developed. A production protocol was designed which allows us to directly obtain membrane proteins in a soluble form by adding detergent during the in vitro protein synthesis. A large number of mainly viral proteins were successfully expressed, and full protocols were developed for the full-length NS2, NS4B and NSSA proteins. These membrane proteins were produced and purified by affinity chromatography using a Strep-tag II in the milligram range. These protein samples are homogenous, as shown by gel filtration analysis. Moreover, structural analyses by circular dichroism showed that the proteins produced in the wheat germ cell-free system are well folded. Reconstitution of these proteins in lipids is currently under optimization. The ultimate goal is to determine their structure by solid-state NMR in a native-like membrane lipids environment
Chen, Hsiuyi V. "Systematic Dissection of Roles for Chromatin Regulators in Dynamics of Transcriptional Response to Stress in Yeast: A Dissertation." eScholarship@UMMS, 2015. http://escholarship.umassmed.edu/gsbs_diss/808.
Повний текст джерелаHuang, Nai-Jia. "The role of TRIM39 in cell cycle and apoptosis." Diss., 2013. http://hdl.handle.net/10161/8245.
Повний текст джерелаWithin individual cells, the opposing processes of proliferation and apoptosis are precisely regulated. When this regulatory balance is interrupted, cells may become abnormal or even transformed. Understanding how to reverse or avoid these detrimental transformative processes begins with an intimate knowledge of the processes governing the cell cycle and apoptosis. Cell proliferation is governed by the cell cycle machinery. The cell cycle is driven by Cyclin-dependent kinase (Cdk) activity, which is dependent on the availability of specific Cyclin binding partners. The amount of available Cyclin is tightly controlled by a ubiquitin ligase protein complex called the anaphase promoting complex/cyclosome (APC/C.) This complex mediates the timely ubiquitylation and degradation of cell cycle regulators in order to control mitotic exit, the G1/S transition and to respond to signals emanating from spindle assembly checkpoint.
Given the importance of the APC/C, cells develop many ways to regulate APC/C activity. Post-translational modifications of the APC/C have been shown to alter its functionality, and many pseudosubstrate-based inhibitors have been discovered. Moreover, inhibitors such as Emi1 and Emi2, have been showed to inhibit the APC/C through their own intrinsic ubiquitin E3 ligase activities. Utilizing the
To extend our observations regarding the role for TRIM39 in APC/C regulation, we investigated effects on the cell cycle via real-time imaging microscopy. We found cells arrest at G1/S in TRIM39 depleted RPE cells, a cell line which is commonly used for cell cycle analysis. This arrest phenotype is not observed in 293T, PC3 and H1299 cells which bear mutant p53 alleles. Further analysis showed that TRIM39 depleted RPE cells upregulate many genes that function downstream of p53 activity, such as the cdk inhibitor p21--thus, arresting cells at G1/S and reducing proliferation. The reduced growth can be rescued by p53 knockdown. Mechanistically, TRIM39 interacts with p53 and promotes destruction of p53 by ubiquitylation. This ubiquitylation is independent of the activity of the most intensively studied p53-directed E3 ligase, MDM2; depletion of both MDM2 and TRIM39 has a synergistic effect on p53 accumulation. This elevated p53 leads to more apoptosis in cancer cells bearing wildtype p53. Consequently, TRIM39 depletion might be employed as a combination treatment with MDM2 inhibitor, such as nutlin-3a, to stimulate tumor cell death.
In the thesis, we have found TRIM39 inhibits both the APC/C and p53. Both are essential regulators of cell cycle and apoptosis. Moreover, we have determined that the inhibitory activity of TRIM39 requires its E3 ligase activity. Future experiments will be directed towards investigating how TRIM39 protein stability and ligase activity are regulated to understand more fully the physiological situations in which TRIM39 is able to exert its ability to modulate the cell cycle and apoptosis. I will also discuss some preliminary data regarding changes in TRIM39 ligase activity induced by Chk1 and changes in TRIM39 protein abundance regulated by polo-like kinase 1(Plk1). Chk1 and Plk1 are essential kinases for cell cycle checkpoint and progression. Connecting Chk1 and Plk1 to TRIM39 may provide a more thorough understanding of TRIM39's ability to control the APC/C inhibition and p53 ubiquitylation in response to cell cycle or cell damage cues. Since the APC/C and p53 both can regulate cell cycle and apoptosis, further investigations into the involvement of TRIM39 in the life-or-death decision will be of great interest.
Dissertation
O'Connell, Brett. "A study of rat skeletal muscle Troponin C isoforms." Thesis, 2005. https://vuir.vu.edu.au/15657/.
Повний текст джерелаBarker, Megan. "Structural Investigation of Processing α-Glucosidase I from Saccharomyces cerevisiae". Thesis, 2010. http://hdl.handle.net/1807/32660.
Повний текст джерела