Статті в журналах: "Bioabsorbable polymers"

1

Shalaby, Shalaby W. "Bioabsorbable polymers update." Journal of Applied Biomaterials 3, no. 1 (1992): 73–74. http://dx.doi.org/10.1002/jab.770030112.

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2

Sharifpanah, Fatemeh, Matthias Reinhardt, Johanna Schönleben, Claudia Meyer, Madeleine Richter, Matthias Schnabelrauch, Claudia Rode, et al. "Embryonic Stem Cells for Tissue Biocompatibility, Angiogenesis, and Inflammation Testing." Cells Tissues Organs 204, no. 1 (2017): 1–12. http://dx.doi.org/10.1159/000471794.

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Aim: To introduce embryoid bodies derived from mouse embryonic stem (ES) cells, which differentiate blood vessel-like structures and leukocytes, as a novel in vitro model system for biocompatibility, inflammation, and angiogenesis studies. Methodology/Results: Punched spherical discs of bioabsorbable polymers (ε-caprolactone and L-lactide in different compositions) with a diameter of 2 mm and a thickness of 0.2 mm were inoculated with embryoid bodies for cocultivation. As reference material for biocompatible, nonbioabsorbable, and bioincompatible materials, polymer punched discs of petriPERM (PP) membrane (polytetrafluoroethylene) as well as polyvinylchloride (PVC) were used. Tissue outgrowth on the polymer discs decreased and cell toxicity increased upon confrontation on bioabsorbable biomaterials and PVC. Bioabsorbable polymers as well as PVC decreased the branching points and total tube length of CD31-positive vascular structures in embryoid bodies. With the exception of PP, all applied materials increased the differentiation of CD68-positive macrophages and the generation of reactive oxygen species, which is indicative of proinflammatory processes upon contact of tissue with biomaterials. Consequently, cocultivation with polymers increased secretion of the cytokines interleukin-6, monocyte chemotactic protein-1, and tumor necrosis factor-α. Conclusion: Three-dimensional tissues cultivated from ES cells are well-suited for testing the biocompatibility, the vascular response, and the inflammatory reaction towards bioabsorbable and nonbioabsorbable polymers.

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3

KIMURA, Yoshiharu. "Biodegradable and Bioabsorbable Polymers." Journal of the Japan Society of Colour Material 64, no. 8 (1991): 512–22. http://dx.doi.org/10.4011/shikizai1937.64.512.

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4

TÖrmälä, P., T. Pohjonen, and P. Rokkanen. "Bioabsorbable polymers: Materials technology and surgical applications." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 212, no. 2 (February 1, 1998): 101–11. http://dx.doi.org/10.1243/0954411981533872.

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Biostable and bioabsorbable biomaterials are used to manufacture implants for supporting, replacement, augmentation and guiding of growth of tissues. Bioabsorbable implants are a better choice for applications where only the temporary presence of the implant is needed. Because of bioabsorption of such implants, there is no need for a removal operation after healing of the tissue and the risks of implant related, long-term complications are eliminated or strongly reduced. Reinforcing of bioabsorbable materials is necessary in order to develop strong and safe, small implants for fixation of bone fractures and connective tissue damage. Self-reinforced bioabsorbable polymeric implants have been used so far extensively in the treatment of traumas of the musculoskeletal system.

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5

Coe, Jeffrey D. "Instrumented transforaminal lumbar interbody fusion with bioabsorbable polymer implants and iliac crest autograft." Neurosurgical Focus 16, no. 3 (March 2004): 1–9. http://dx.doi.org/10.3171/foc.2004.16.3.12.

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Object The purpose of this study was to evaluate the clinical and radiographic results in 31 patients from one center who underwent instrumented transforaminal lumbar interbody fusion (TLIF) for primarily degenerative indications. Methods Bioabsorbable polymer spacers manufactured with a copolymer of 70:30 poly(L-lactide-co-D,L-lactide) and filled with iliac crest autograft bone were used for the TLIF procedure. In this paper the details of this procedure, intermediate (1- to 2-year) clinical and radiographic outcomes, and the basic science and rationale for the use of bioabsorbable polymers are discussed. At a mean of 18.4 months of follow up, 30 patients (96.8%) were judged to have attained solid fusions and 25 patients (81%) had good to excellent results. Three patients (9.7%) experienced complications, none of which were directly or indirectly attributable to the use of the bioabsorbable polymer implant. Only one implant in one patient (3.2%) demonstrated mechanical failure on insertion, and that patient experienced no clinical sequelae. Conclusions This is the first clinical series to be published in which the mean follow-up duration equals or exceeds the biological life expectancy of this material (12–18 months). Both the clinical and radiographic results of this study support the use of interbody devices manufactured from biodegradable polymers for structural interbody support in the TLIF procedure.

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6

Vert, Michel. "Bioabsorbable polymers in medicine: an overview." EuroIntervention 5, F (December 2009): F9—F14. http://dx.doi.org/10.4244/eijv5ifa2.

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7

Ebisawa, Mizue. "Optical Measurement of Bioabsorbable Crystalline Polymers." IEEJ Transactions on Fundamentals and Materials 132, no. 6 (2012): 458–59. http://dx.doi.org/10.1541/ieejfms.132.458.

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8

Sinha, Vivek R., and Lara Khosla. "Bioabsorbable Polymers for Implantable Therapeutic Systems." Drug Development and Industrial Pharmacy 24, no. 12 (January 1998): 1129–38. http://dx.doi.org/10.3109/03639049809108572.

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9

Vaccaro, Alexander R., and Luke Madigan. "Spinal applications of bioabsorbable implants." Journal of Neurosurgery: Spine 97, no. 4 (November 2002): 407–12. http://dx.doi.org/10.3171/spi.2002.97.4.0407.

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✓ With the increasing use of bioabsorbable implants in a variety of clinical conditions, potential advantages in selected spinal applications are now being realized. Newer polymers with biomechanical properties relevant to the requirements of specific spinal implants and resorption rates appropriate for specific spinal applications are being developed. These new materials offer the necessary biomechanical stability of conventional spinal implants without the sequelae associated with metallic implants such as long-term loosening, implant migration, and imaging interference. At this time, the majority of clinical applications for these new polymers have involved tension band plating in the lumbar and anterior cervical spine, anterior spinal interbody reconstruction, posterior bone graft containment, and bone graft harvest site reconstruction.

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10

Giardino, Roberto, Milena Fini, Nicolo Nicoli Aldini, Gianluca Giavaresi, and Michele Rocca. "Polylactide Bioabsorbable Polymers for Guided Tissue Regeneration." Journal of Trauma: Injury, Infection, and Critical Care 47, no. 2 (August 1999): 303–8. http://dx.doi.org/10.1097/00005373-199908000-00014.

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11

TAKASAWA, HIROAKI. "Development of Medical Devices Using Bioabsorbable Polymers." Sen'i Gakkaishi 52, no. 7 (1996): P270—P278. http://dx.doi.org/10.2115/fiber.52.7_p270.

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12

Alfonso, Fernando. "New Drug-eluting Stents: Polymer-free, Biodegradable Polymers or Bioabsorbable Scaffolds?" Revista Española de Cardiología (English Edition) 66, no. 6 (June 2013): 423–26. http://dx.doi.org/10.1016/j.rec.2013.02.005.

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13

Alexy, Ryan D., and Daniel S. Levi. "Materials and Manufacturing Technologies Available for Production of a Pediatric Bioabsorbable Stent." BioMed Research International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/137985.

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Transcatheter treatment of children with congenital heart disease such as coarctation of the aorta and pulmonary artery stenosis currently involves the use of metal stents. While these provide good short term results, there are long term complications with their use. Children outgrow metal stents, obligating them to future transcatheter dilations and eventual surgical removal. A bioabsorbable stent, or a stent that goes away with time, would solve this problem. Bioabsorbable stents are being developed for use in coronary arteries, however these are too small for use in pediatric congenital heart disease. A bioabsorbable stent for use in pediatric congenital heart disease needs to be low profile, expandable to a diameter 8 mm, provide sufficient radial strength, and absorb quickly enough to allow vessel growth. Development of absorbable coronary stents has led to a great understanding of the available production techniques and materials such as bioabsorbable polymers and biocorrodable metals. Children with congenital heart disease will hopefully soon benefit from the current generation of bioabsorbable and biocorrodable materials and devices.

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14

Yamada, Keisuke, Susumu Miyamoto, Izumi Nagata, Haruhiko Kikuchi, Yoshito Ikada, Hiroo Iwata, and Kazuo Yamamoto. "Development of a dural substitute from synthetic bioabsorbable polymers." Journal of Neurosurgery 86, no. 6 (June 1997): 1012–17. http://dx.doi.org/10.3171/jns.1997.86.6.1012.

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✓ A new bioabsorbable composite sheet was developed to provide a substitute for the dura mater and was evaluated histologically and biomechanically using rats and rabbits. This composite, composed of two l-lactic acid-ϵ-caprolactone (50% l-lactic acid, 50% ϵ-caprolactone) copolymer films and a poly(glycolic acid) nonwoven fabric, displayed good mechanical properties and was completely absorbed 24 weeks after implantation in the back of rats. Histological evaluation of the composite sheet was undertaken by implanting it in 31 rabbits with dural defects and examining the sites of implantation 2 weeks to 26 months later. No infection, cerebrospinal fluid leakage, evidence of convulsive disorders, significant adhesion to underlying cortex, or calcification was noticed in any cases. In addition, the regenerated duralike tissue had a high pressure-resistant strength 2 weeks after implantation. The authors conclude that this new bioabsorbable composite sheet can be successfully used as a dural substitute.

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15

Takasawa, H. "Application to the Medical Device Using Bioabsorbable Polymers." Sen'i Kikai Gakkaishi (Journal of the Textile Machinery Society of Japan) 49, no. 2 (1996): P111—P121. http://dx.doi.org/10.4188/transjtmsj.49.p111.

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16

Siparsky, Patrick N., Paul Gramenz, Kenneth Gall, Robert D'Ambrosia, and Reed L. Bartz. "Bioabsorbable Polymers Used in Knee Arthroscopy, Part 1." Techniques in Knee Surgery 5, no. 3 (September 2006): 193–98. http://dx.doi.org/10.1097/01.btk.0000221928.66783.28.

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17

Gramenz, Paul, Patrick N. Siparsky, Kenneth Gall, Robert D'Ambrosia, and Reed L. Bartz. "Bioabsorbable Polymers Used in Knee Arthroscopy, Part 2." Techniques in Knee Surgery 5, no. 3 (September 2006): 199–204. http://dx.doi.org/10.1097/01.btk.0000221929.66783.61.

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18

Shalaby, Shalaby W., and Karen J. L. Burg. "Bioabsorbable polymers update: Degradation mechanisms, safety, and application." Journal of Applied Biomaterials 6, no. 3 (1995): 219–21. http://dx.doi.org/10.1002/jab.770060313.

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19

Sakuma, Kei, Atsushi Iguchi, Yoshito Ikada, and Koichi Tabayashi. "Closure of the Pericardium Using Synthetic Bioabsorbable Polymers." Annals of Thoracic Surgery 80, no. 5 (November 2005): 1835–40. http://dx.doi.org/10.1016/j.athoracsur.2005.04.078.

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20

On, Sung-Woon, Seoung-Won Cho, Soo-Hwan Byun, and Byoung-Eun Yang. "Bioabsorbable Osteofixation Materials for Maxillofacial Bone Surgery: A Review on Polymers and Magnesium-Based Materials." Biomedicines 8, no. 9 (August 21, 2020): 300. http://dx.doi.org/10.3390/biomedicines8090300.

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Clinical application of osteofixation materials is essential in performing maxillofacial surgeries requiring rigid fixation of bone such as trauma surgery, orthognathic surgery, and skeletal reconstruction. In addition to the use of titanium plates and screws, clinical applications and attempts using bioabsorbable materials for osteofixation surgery are increasing with demands to avoid secondary surgery for the removal of plates and screws. Synthetic polymeric plates and screws were developed, reaching satisfactory physical properties comparable to those made with titanium. Although these polymeric materials are actively used in clinical practice, there remain some limitations to be improved. Due to questionable physical strength and cumbersome molding procedures, interests in resorbable metal materials for osteofixation emerged. Magnesium (Mg) gained attention again in the last decade as a new metallic alternative, and numerous animal studies to evaluate the possibility of clinical application of Mg-based materials are being conducted. Thanks to these researches and studies, vascular application of Mg-based biomaterials was successful; however, further studies are required for the clinical application of Mg-based biomaterials for osteofixation, especially in the facial skeleton. The review provides an overview of bioabsorbable osteofixation materials in maxillofacial bone surgery from polymer to Mg.

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21

Rusa, C. C., X. Shuai, I. D. Shin, T. A. Bullions, M. Wei, F. E. Porbeni, J. Lu, L. Huang, J. Fox, and A. E. Tonelli. "Controlling the Behaviors of Biodegradable/Bioabsorbable Polymers with Cyclodextrins." Journal of Polymers and the Environment 12, no. 3 (July 2004): 157–63. http://dx.doi.org/10.1023/b:jooe.0000038547.36750.78.

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22

Vacanti, Joseph P., Martin A. Morse, W. Mark Saltzman, Abraham J. Domb, Antonio Perez-Atayde, and Robert Langer. "Selective cell transplantation using bioabsorbable artificial polymers as matrices." Journal of Pediatric Surgery 23, no. 1 (January 1988): 3–9. http://dx.doi.org/10.1016/s0022-3468(88)80529-3.

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23

Manson, Joanne, and Dorian Dixon. "The Influence of Solvent Processing on Polyester Bioabsorbable Polymers." Journal of Biomaterials Applications 26, no. 5 (July 21, 2010): 623–34. http://dx.doi.org/10.1177/0885328210376997.

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24

Saberi, Abbas, Hamid Reza Bakhsheshi-Rad, Somayeh Abazari, Ahmad Fauzi Ismail, Safian Sharif, Seeram Ramakrishna, Mohammadreza Daroonparvar, and Filippo Berto. "A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges." Coatings 11, no. 7 (June 22, 2021): 747. http://dx.doi.org/10.3390/coatings11070747.

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The development of biodegradable implants is certainly intriguing, and magnesium and its alloys are considered significant among the various biodegradable materials. Nevertheless, the fast degradation, the generation of a significant amount of hydrogen gas, and the escalation in the pH value of the body solution are significant barriers to their use as an implant material. The appropriate approach is able to solve this issue, resulting in a decrease the rate of Mg degradation, which can be accomplished by alloying, surface adjustment, and mechanical treatment. Surface modification is a practical option because it not only improves corrosion resistance but also prepares a treated surface to improve bone regeneration and cell attachment. Metal coatings, ceramic coatings, and permanent polymers were shown to minimize degradation rates, but inflammation and foreign body responses were also suggested. In contrast to permanent materials, the bioabsorbable polymers normally show the desired biocompatibility. In order to improve the performance of drugs, they are generally encapsulated in biodegradable polymers. This study summarized the most recent advancements in manufacturing polymeric coatings on Mg alloys. The related corrosion resistance enhancement strategies and future potentials are discussed. Ultimately, the major challenges and difficulties are presented with aim of the development of polymer-coated Mg-based implant materials.

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25

Kobo, Ofer, and Ariel Roguin. "Orsiro: ultrathin bioabsorbable polymer sirolimus-eluting stent." Future Cardiology 15, no. 4 (July 2019): 295–300. http://dx.doi.org/10.2217/fca-2019-0001.

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Recent stent developments aimed to reduce and eliminate the long-term inflammatory response include thinner struts, modifications to stent design and the development of bioresorbable polymers (BP). We aimed to summarize the main findings and to discuss the established and the potential benefits of the Orsiro BP sirolimus-eluting stents in everyday clinical use. We have reviewed the available evidence on the clinical performance of the Orsiro BP drug-eluting stents. Orsiro BP sirolimus-eluting stents is clinically proven and showed noninferiority against major drug-eluting stents and provides high safety and efficacy profile at long-term follow-up. Furthermore, it may be the preferred treatment option in specific subgroups as acute coronary syndrome, as shown in the BIOFLOW V trial.

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26

Gradwohl, Marion, Feng Chai, Julien Payen, Pierre Guerreschi, Philippe Marchetti, and Nicolas Blanchemain. "Effects of Two Melt Extrusion Based Additive Manufacturing Technologies and Common Sterilization Methods on the Properties of a Medical Grade PLGA Copolymer." Polymers 13, no. 4 (February 14, 2021): 572. http://dx.doi.org/10.3390/polym13040572.

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Although bioabsorbable polymers have garnered increasing attention because of their potential in tissue engineering applications, to our knowledge there are only a few bioabsorbable 3D printed medical devices on the market thus far. In this study, we assessed the processability of medical grade Poly(lactic-co-glycolic) Acid (PLGA)85:15 via two additive manufacturing technologies: Fused Filament Fabrication (FFF) and Direct Pellet Printing (DPP) to highlight the least destructive technology towards PLGA. To quantify PLGA degradation, its molecular weight (gel permeation chromatography (GPC)) as well as its thermal properties (differential scanning calorimetry (DSC)) were evaluated at each processing step, including sterilization with conventional methods (ethylene oxide, gamma, and beta irradiation). Results show that 3D printing of PLGA on a DPP printer significantly decreased the number-average molecular weight (Mn) to the greatest extent (26% Mn loss, p < 0.0001) as it applies a longer residence time and higher shear stress compared to classic FFF (19% Mn loss, p < 0.0001). Among all sterilization methods tested, ethylene oxide seems to be the most appropriate, as it leads to no significant changes in PLGA properties. After sterilization, all samples were considered to be non-toxic, as cell viability was above 70% compared to the control, indicating that this manufacturing route could be used for the development of bioabsorbable medical devices. Based on our observations, we recommend using FFF printing and ethylene oxide sterilization to produce PLGA medical devices.

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27

Qureshi, Ammar T., W. Todd Monroe, Mandi J. Lopez, Marlene E. Janes, Vinod Dasa, Sunggook Park, Alborz Amirsadeghi, and Daniel J. Hayes. "Biocompatible/bioabsorbable silver nanocomposite coatings." Journal of Applied Polymer Science 120, no. 5 (January 12, 2011): 3042–53. http://dx.doi.org/10.1002/app.33481.

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28

Yamada, Keisuke, Susumu Miyamoto, Motohiro Takayama, Izumi Nagata, Nobuo Hashimoto, Yoshito Ikada, and Haruhiko Kikuchi. "Clinical application of a new bioabsorbable artificial dura mater." Journal of Neurosurgery 96, no. 4 (April 2002): 731–35. http://dx.doi.org/10.3171/jns.2002.96.4.0731.

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Object. In their pursuit of a better substitute for dura mater in neurosurgical procedures, the authors review their experience with GM972. Methods. A newly developed synthetic dural substitute composed of bioabsorbable polymers (GM972) was placed in 53 patients during neurosurgical procedures. The handling properties of the material, surgical wound features, and findings of hematological, computerized tomography, and/or magnetic resonance imaging examinations were evaluated. The average follow-up period was 35.5 months. The handling properties and biocompatibility of this new dural substitute were highly satisfactory, and no significant complication was observed. In patients who underwent a second surgery performed more than 18 months after the initial operation, this new dural substitute was found to have been replaced by autologous collagenous tissue. Because of its bioabsorbability, chronic foreign body reactions to this synthetic dural substitute were negligible. Conclusions. In this report the authors support the effectiveness and safety of this bioabsorbable artificial dural substitute that provides a reduced risk of transmission of latent infection.

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29

Aldini, N. Nicoli, M. Fini, M. Rocca, L. Martini, R. Giardino, P. Caliceti, F. M. Veronese, S. Lora, and M. C. Maltarello. "Peripheral Nerve Reconstruction with Bioabsorbable Polyphosphazene Conduits." Journal of Bioactive and Compatible Polymers 12, no. 1 (January 1997): 3–13. http://dx.doi.org/10.1177/088391159701200101.

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30

Lungu, Ramona, Maria-Alexandra Paun, Dragos Peptanariu, Daniela Ailincai, Luminita Marin, Mihai-Virgil Nichita, Vladimir-Alexandru Paun, and Viorel-Puiu Paun. "Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings." Gels 8, no. 2 (February 10, 2022): 107. http://dx.doi.org/10.3390/gels8020107.

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Supramolecular hydrogels based on chitosan and monoaldehydes are biomaterials with high potential for a multitude of bioapplications. This is due to the proper choice of the monoaldehyde that can tune the hydrogel properties for specific practices. In this conceptual framework, the present paper deals with the investigation of a hydrogel as bioabsorbable wound dressing. To this aim, chitosan was cross-linked with 2-formylphenylboronic acid to yield a hydrogel with antimicrobial activity. FTIR, NMR, and POM procedures have characterized the hydrogel from a structural and supramolecular point of view. At the same time, its biocompatibility and antimicrobial properties were also determined in vitro. Furthermore, in order to assess the bioabsorbable character, its biodegradation was investigated in vitro in the presence of lysosome in media of different pH, mimicking the wound exudate at different stages of healing. The biodegradation was monitored by gravimetrical measurements, SEM microscopy and fractal analyses of the images. The fractal dimension values and the lacunarity of SEM pictures were accurately calculated. All these successful investigations led to the conclusion that the tested materials are at the expected high standards.

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31

Hasson, Jonathan E. "Adult Human Vascular Endothelial Cell Attachment and Migration on Novel Bioabsorbable Polymers." Archives of Surgery 122, no. 4 (April 1, 1987): 428. http://dx.doi.org/10.1001/archsurg.1987.01400160054007.

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32

Carroll, P. A., S. A. Bell, A. S. Maxwell, and P. E. Tomlins. "Non-destructive Moisture Content Measurement of Bioabsorbable Polymers Used in Medical Implants." International Journal of Thermophysics 33, no. 8-9 (May 1, 2011): 1650–60. http://dx.doi.org/10.1007/s10765-011-0981-3.

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33

Ashammakhi, Nureddin, Minna Veiranto, Sanna-Mari Niemelä, J. Tiainen, S. Leinonen, Esa Suokas, and Pertti Törmälä. "Development of Multifunctional Materials (MFM): Bioabsorbable Drug-Releasing Hard Tissue Fixation Screws." Materials Science Forum 492-493 (August 2005): 195–200. http://dx.doi.org/10.4028/www.scientific.net/msf.492-493.195.

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To develop a successful bone fixation device that can also release therapeutic agents such as antibiotics one has to consider mechanical, drug release, and biocompatibility properties. We have used bioabsorbable polymers (PLGA 80/20 or PLDLA 70/30) as the matrix and ciprofloxacin (CF) as antibiotic to develop such an implant. Initial shear strengths of the studied ciprofloxacinreleasing screws were 152 MPa (P/L/DL)LA) and 172 MPa (PLGA). Studied screws retained their mechanical properties for least 12 weeks (P(L/DL)LA) and 9 weeks (PLGA) in vitro at the level that ensures their fixation properties. Pull-out tests indicated that the early version of screws have lower values as compared to controls. CF was found to be released after 44 weeks (P/L/DL)LA) and 23 weeks (PLGA) in vitro. It remained in the range of 0.06 – 8.7 µg/ml/day (for P(L/DL)LA) and 0.6 - 11.6 µg/ml/day (for PLGA) after the jump start. Release CF was demonstrated to significantly inhibit S. epidermides growth, attachment and biofilm formation different than controls. Histology showed no difference from plain polymer screws, except for increased giant cells at the implantation site. Accordingly, SR-P(L/DL)LA and SR-PLGA MF implants were considered appropriate to proceed to pilot clinical application.

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34

Sonawane, Vratika C., Mahesh P. More, Abhijeet P. Pandey, Pravin O. Patil, and Prashant K. Deshmukh. "Fabrication and characterization of shape memory polymers based bioabsorbable biomedical drug eluting stent." Artificial Cells, Nanomedicine, and Biotechnology 45, no. 8 (January 31, 2017): 1740–50. http://dx.doi.org/10.1080/21691401.2017.1282867.

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35

Ma, Jianbiao, Haihui Cao, Yanhong Li, and Youxin Li. "Synthesis and characterization of poly(DL-lactide)-grafted gelatins as bioabsorbable amphiphilic polymers." Journal of Biomaterials Science, Polymer Edition 13, no. 1 (January 2002): 67–80. http://dx.doi.org/10.1163/156856202753525945.

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36

Stock, Ulrich A., Takahiko Sakamoto, Shinichi Hatsuoka, David P. Martin, Mitsugi Nagashima, Adrian M. Moran, Marsha A. Moses, et al. "Patch augmentation of the pulmonary artery with bioabsorbable polymers and autologous cell seeding." Journal of Thoracic and Cardiovascular Surgery 120, no. 6 (December 2000): 1158–67. http://dx.doi.org/10.1067/mtc.2000.109539.

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37

Kortaberria, Galder, Amaia Jimeno, Puy Arruti, Koro de la Caba, Pedro Remiro, Arantxa Eceiza, and Iñaki Mondragon. "Molecular Dynamics of PGA Bioabsorbable Polymer During Isothermal Cold Crystallization." Macromolecular Symposia 239, no. 1 (June 2006): 152–58. http://dx.doi.org/10.1002/masy.200690092.

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38

Li, Jun, Xu Li, Xiping Ni, Xin Wang, Hongzhe Li, and Zhi Han Zhou. "Injectable Supramolecular Hydrogels Self-Assembled by Polymers and Cyclodextrins for Controlled Drug Delivery." Key Engineering Materials 288-289 (June 2005): 117–20. http://dx.doi.org/10.4028/www.scientific.net/kem.288-289.117.

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Of many polymeric biomaterials, hydrogels are of special importance because of their favorable biocompatibility and pertinence in delivering delicate bioactive agents such as proteins. Physical hydrogels have attracted much attention for controlled drug delivery because of the mild and aqueous conditions involved in trapping bioactive agents. This paper reviews our recent progress on developing a new class of physical hydrogels based on the supramolecular self-assembly between cyclodextrins and bioabsorbable poly(ethylene oxide) (PEO) or its copolymers. Being thixotropic, the hydrogels can be injected through needles and applied as injectable drug delivery systems. The properties of the hydrogels also can be fine-tuned with triblock copolymers where PEO segments flank hydrophobic or biodegradable segments in the middle.

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Mushtaq, Muhammad, Muhammad Wasim, Muhammad Naeem, Muhammad Khan, Sun Yue, Hina Saba, Tanveer Hussain, Muhammad Siddiqui, Amjad Farooq, and Qufu Wei. "Composite of PLA Nanofiber and Hexadecyl Trimethyl-Ammonium Chloride-Modified Montmorillonite Clay: Fabrication and Morphology." Coatings 10, no. 5 (May 18, 2020): 484. http://dx.doi.org/10.3390/coatings10050484.

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Our research aim is to develop a new composite material via electrospinning and dip coating methodology. Among bioabsorbable polymers, Polylactic acid (PLA) is viewed as a suitable base material for biomedical usages such as drug delivery and wound dressing. Additionally, these bioabsorbable materials can be used for filtration applications in terms of antibacterial activity the integration of hexadecyl trimethyl ammonium chloride-modified montmorillonite (CTAC-MMT) into PLA fibers would improve mechanical and absorption properties of the PLA fibers. This research aimed to investigated a new method of combining electrospun PLA with dip coating of CTAC-MMT solution. Precisely, electrospun PLA nanofibers were treated with methanol and dipped in a CTAC-MMT suspension. The resultant layer composite of PLA nanofibers and CTAC-MMT was then characterized by elemental analysis. For material characterization and morphological structure analysis, we performed FTIR, SEM-EDS, XPS, DSC, and X-ray diffraction. Through mechanical testing and contact angle measurements, it was found that CTAC-MMT shows a slight improvement in mechanical and absorption properties. Results of characterization techniques have shown that CTAC-MMT can be used as a good filler for composites processed through the dip-coating method. Moreover, results also showed that the diameter of microfibers is affected by concentrations of PLA.

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40

Xavier, Mariana, Nayla Farez, Paola Luciana Salvatierra, Andre Luiz Jardini, Paulo Kharmandayan, and Sara Feldman. "Biological performance of a bioabsorbable Poly (L-Lactic Acid) produced in polymerization unit: in vivo studies." F1000Research 10 (December 13, 2021): 1275. http://dx.doi.org/10.12688/f1000research.73754.1.

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Background: The biomaterials engineering goal is to manufacture a biocompatible scaffold that adequately supports or improves tissue regeneration after implantation of the biomaterial in the injured area. Many requirements are demanded for a biomaterial, such as biocompatibility, elasticity, degradation time, and a very important factor is its cost of importation or synthesis, making its application inaccessible to some countries. Studies about biomaterials market show that Polylactic acid (PLLA) is one of the most used polymers, but expensive to produce. It becomes important to prove the biocompatibility of the new PLLA and to find strategies to produce biocompatible biopolymers at an acceptable production cost. Methods: In this work, the polylactic acid biomaterial was synthesized by ring-opening polymerization. The polymer was submitted to initial in vivo biocompatibility studies in 12 New Zealand female rabbits, assigned to two groups: (1) Lesion and PLLA group (n = 6), (2) Lesion No PLLA group (n = 6). Each group was divided into two subgroups at six and nine months post-surgical time. Before euthanasia clinical and biochemical studies were performed and after that tomographic (CT), histological (Hematoxylin and Eosin and Masson's trichrome) and histomorphometric analyses were performed to evaluate the injury site and prove biocompatibility. The final cost of this polymer was analyzed. Results: The statistical studies of hemogram and hepatocyte enzymes, showed that there were no significant differences between the groups for any of the times studied, in any of the variables considered and the results of CT and histology showed that there was an important process of neoregeneration. The cost analysis showed the biopolymer synthesis is between R$3,06 - R$5,49 cheaper than the import cost. Conclusions: It was possible to synthesize the PLLA biopolymer by cyclic ring opening, which proved to be biocompatible, potential osteoregenerative and cheaper than other imported biopolymers.

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41

Wu, Lei, Xujian Li, Pengpeng Li, Luqi Pan, Zhixiao Ji, Yakai Feng, and Changcan Shi. "Bioabsorbable flexible elastomer of PTMC‐b‐PEG‐b‐PTMC copolymer as intestinal anastomosis scaffold." Polymers for Advanced Technologies 32, no. 9 (May 11, 2021): 3633–45. http://dx.doi.org/10.1002/pat.5371.

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42

Tanaka, Satoshi, Toshikazu Takigawa, Satoshi Ichihara, and Tatsuo Nakamura. "Mechanical properties of the bioabsorbable polyglycolic acid-collagen nerve guide tube." Polymer Engineering & Science 46, no. 10 (August 24, 2006): 1461–67. http://dx.doi.org/10.1002/pen.20600.

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43

Tunc, D. C., M. Goekbora, and P. Higham. "A new method for the estimation for the absorption time of bioabsorbable polymers in the body." Technology and Health Care 10, no. 3-4 (July 8, 2002): 237–42. http://dx.doi.org/10.3233/thc-2002-103-409.

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44

Duarte, Marcia Adriana Tomaz, Larissa Coppini, C. Lucchesi, Marcelo Macedo, and Eliana Aparecida De Rezende Duek. "The Influence of the PCL-T Concentration in PLDLA Membrane." Materials Science Forum 730-732 (November 2012): 50–55. http://dx.doi.org/10.4028/www.scientific.net/msf.730-732.50.

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The use of bioabsorbable polymers in biomedical application has increased greatly in recent years due to their good compatibility and bio-reabsorption. To obtain a polymeric material suitable for medical applications, the obtention and characterization of copolymer poly (L-co-DL lactic acid) (PLDLA) with the addition of poly (caprolactone triol) (PCL-T) was studied. PLDLA/PCL-T membranes were prepared by solvent casting in the 100/0, 90/10 and 70/30 (w/w) compositions. The membranes were characterized by Atomic Force Microscopy (AFM), Cellular Adhesion and Energy Dispersed Spectroscopy (EDS). Using MFA it was observed that an addition of PCL-T contributes to rough morphology and greater porosity. Increased cell adhesion on 90/10 and 70/30 membranes compared to 100/0 composition and controls was observed. From these results, it was observed that PCL-T improved cellular adhesion of the PLDLA membrane when compared to membranes without PCL-T. The PLDLA/PCL-T membrane is indicated for use in medical devices which do not require long implantation time, such as support for cell culture, dressings for skin ulceration and guided regeneration in periodontics.

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45

Storey, Robson F., Jeffrey S. Wiggins, Kenneth A. Mauritz, and Aaron D. Puckett. "Bioabsorbable composites. I: Fundamental design considerations using free radically crosslinkable matrices." Polymer Composites 14, no. 1 (February 1993): 7–16. http://dx.doi.org/10.1002/pc.750140103.

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46

Storey, Robson F., and Kelly A. Shoemake. "Poly(glycolic acid) fiber-reinforced bioabsorbable composites with improved interfacial properties." Polymer Bulletin 31, no. 3 (September 1993): 331–38. http://dx.doi.org/10.1007/bf00692960.

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47

Jang, Jin-Woon, Jin Kim, Min-Suk Kook, and Ki-Young Lee. "Evaluation of Gellan Gum/Glycol Chitosan Bioabsorbable Membrane for Guided Bone Regeneration." Polymer Korea 42, no. 5 (September 30, 2018): 874–81. http://dx.doi.org/10.7317/pk.2018.42.5.874.

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48

Özcan, Mutlu, Dachamir Hotza, Márcio Celso Fredel, Ariadne Cruz, and Claudia Angela Maziero Volpato. "Materials and Manufacturing Techniques for Polymeric and Ceramic Scaffolds Used in Implant Dentistry." Journal of Composites Science 5, no. 3 (March 11, 2021): 78. http://dx.doi.org/10.3390/jcs5030078.

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Preventive and regenerative techniques have been suggested to minimize the aesthetic and functional effects caused by intraoral bone defects, enabling the installation of dental implants. Among them, porous three-dimensional structures (scaffolds) composed mainly of bioabsorbable ceramics, such as hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) stand out for reducing the use of autogenous, homogeneous, and xenogenous bone grafts and their unwanted effects. In order to stimulate bone formation, biodegradable polymers such as cellulose, collagen, glycosaminoglycans, polylactic acid (PLA), polyvinyl alcohol (PVA), poly-ε-caprolactone (PCL), polyglycolic acid (PGA), polyhydroxylbutyrate (PHB), polypropylenofumarate (PPF), polylactic-co-glycolic acid (PLGA), and poly L-co-D, L lactic acid (PLDLA) have also been studied. More recently, hybrid scaffolds can combine the tunable macro/microporosity and osteoinductive properties of ceramic materials with the chemical/physical properties of biodegradable polymers. Various methods are suggested for the manufacture of scaffolds with adequate porosity, such as conventional and additive manufacturing techniques and, more recently, 3D and 4D printing. The purpose of this manuscript is to review features concerning biomaterials, scaffolds macro and microstructure, fabrication techniques, as well as the potential interaction of the scaffolds with the human body.

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Casarin, Suzan Aline, Sônia Maria Malmonge, Marcio Kobayashi, and José Augusto Marcondes Agnelli. "Study on In-Vitro Degradation of Bioabsorbable Polymers Poly (hydroxybutyrate-co-valerate) - (PHBV) and Poly (caprolactone) - (PCL)." Journal of Biomaterials and Nanobiotechnology 02, no. 03 (2011): 207–15. http://dx.doi.org/10.4236/jbnb.2011.23026.

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Huang, Lei, Heidi Taylor, Michael Gerber, Paul E. Orndorff, John R. Horton, and Alan Tonelli. "Formation of antibiotic, biodegradable/bioabsorbable polymers by processing with neomycin sulfate and its inclusion compound with ?-cyclodextrin." Journal of Applied Polymer Science 74, no. 4 (October 24, 1999): 937–47. http://dx.doi.org/10.1002/(sici)1097-4628(19991024)74:4<937::aid-app20>3.0.co;2-k.

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