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Статті в журналах з теми "Binge-like drinking"
Pozhidayeva, Dar’ya Y., Sean P. Farris, Calla M. Goeke, Evan J. Firsick, Kayla G. Townsley, Marina Guizzetti, and Angela R. Ozburn. "Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes." Brain Sciences 10, no. 2 (February 18, 2020): 109. http://dx.doi.org/10.3390/brainsci10020109.
Повний текст джерелаYOUNG, AMY M., MICHELE MORALES, SEAN ESTEBAN McCABE, CAROL J. BOYD, and HANNAH D'ARCY. "Drinking Like a Guy: Frequent Binge Drinking Among Undergraduate Women." Substance Use & Misuse 40, no. 2 (January 2005): 241–67. http://dx.doi.org/10.1081/ja-200048464.
Повний текст джерелаCzapla, Marta, Joe J. Simon, Hans-Christoph Friederich, Sabine C. Herpertz, Peter Zimmermann, and Sabine Loeber. "Is Binge Drinking in Young Adults Associated with an Alcohol-Specific Impairment of Response Inhibition?" European Addiction Research 21, no. 2 (November 22, 2014): 105–13. http://dx.doi.org/10.1159/000367939.
Повний текст джерелаGutema, Hordofa, Yamrot Debela, Bizuayehu Walle, Kidist Reba, Tebkew Shibabaw, and Tolera Disasa. "Predicting binge drinking among university students: Application of integrated behavioral model." PLOS ONE 16, no. 7 (July 9, 2021): e0254185. http://dx.doi.org/10.1371/journal.pone.0254185.
Повний текст джерелаGrigsby, Kolter, Courtney Ledford, Tanvi Batish, Snigdha Kanadibhotla, Delaney Smith, Evan Firsick, Alexander Tran, et al. "Targeting the Maladaptive Effects of Binge Drinking on Circadian Gene Expression." International Journal of Molecular Sciences 23, no. 19 (September 21, 2022): 11084. http://dx.doi.org/10.3390/ijms231911084.
Повний текст джерелаNentwig, Todd B., Colleen E. McGonigle, Diane E. Wilson, Erin M. Rhinehart, and Judith E. Grisel. "Beta-endorphin modulates binge-like ethanol drinking in mice." Alcohol 60 (May 2017): 240. http://dx.doi.org/10.1016/j.alcohol.2017.02.342.
Повний текст джерелаQueiroz, Letícia Yoshitome, Igor Gonçalves de Oliveira, Sabrina de Carvalho Cartágenes, Luanna Melo Pereira Fernandes, Sávio Monteiro dos Santos, Wallax Augusto Silva Ferreira, Fernando Augusto Rodrigues Mello Junior, et al. "Repeated Cycles of Binge-Like Ethanol Exposure Induces Neurobehavioral Changes During Short- and Long-Term Withdrawal in Adolescent Female Rats." Oxidative Medicine and Cellular Longevity 2022 (October 25, 2022): 1–11. http://dx.doi.org/10.1155/2022/7207755.
Повний текст джерелаLikashi, Danny Vumbi, Ravi Paul, and Luty Jason. "The Proportion of Binge Drinking Among Female Social Drinkers of Kalingalinga in Lusaka, Zambia: A Pilot Study." Global Psychiatry 2, no. 1 (March 25, 2019): 43–50. http://dx.doi.org/10.2478/gp-2019-0005.
Повний текст джерелаRadke, Anna K., Elizabeth A. Sneddon, Raizel M. Frasier, and Frederic W. Hopf. "Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking." International Journal of Molecular Sciences 22, no. 7 (April 6, 2021): 3788. http://dx.doi.org/10.3390/ijms22073788.
Повний текст джерелаGrigsby, Kolter B., Antonia M. Savarese, Pamela Metten, Barbara J. Mason, Yuri A. Blednov, John C. Crabbe, and Angela R. Ozburn. "Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark Mice." Neuroscience Insights 15 (January 2020): 263310552097541. http://dx.doi.org/10.1177/2633105520975412.
Повний текст джерелаДисертації з теми "Binge-like drinking"
Linsenbardt, David Nathaniel. "Agonism of the endocannabinoid system modulates binge-like alcohol intake in male C57BL/6J mice involvement of the posterior ventral tegmental area /." Diss., Online access via UMI:, 2008.
Знайти повний текст джерелаAli, Syed Aoun. "Sugar consumption and expression of neuronal nicotinic receptors in the Nucleus Accumbens." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/208972/1/Syed%20Aoun_Ali_Thesis.pdf.
Повний текст джерелаKasten, Chelsea Rae. "Intra-nucleus accumbens shell injections of R(+)- and S(-)- baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57Bl/6J mice." Thesis, Behavioural Brain Research (Elsevier), 2014. http://hdl.handle.net/1805/6453.
Повний текст джерелаIt has been proposed that the GABAB receptor subtype plays a role in alcoholism and alcohol use disorders (AUDs) (Cousins et al., 2002; Agabio et al., 2012). Specifically, the GABAB agonist baclofen has been looked at extensively in clinical and pre-clinical studies. In various animal models of chronic and intermittent consumption, baclofen has been shown to both increase (Petry, 1997; Smith et al., 1999; Czachowski et al., 2006; Moore et al., 2007) and decrease (Colombo et al., 2000; 2002; 2005; Stromberg, 2004; Moore et al., 2009) drinking. A critical issue in determining pharmacological effects of a drug is using the appropriate animal model. The drinking-in-the-dark (DID) model, developed by Rhodes et al. (2005, 2007), produces high levels of drinking in a binge-like paradigm and has been used to assess many pharmacological targets (e.g. Kamdar et al., 2007; Gupta et al., 2008; Moore et al., 2007; 2009). While DID produces high-levels of binge drinking, it is unclear what areas of the brain are involved in this behavior. A direct way to target areas that are believed to be involved in the circuitry of particular behaviors is through microinjection of drugs (Kiianmaa et al., 2003). Of particular recent interest involving motivated behaviors and addiction is the nucleus accumbens (Acb) (Everitt & Robbins, 2005); specifically the accumbens shell (AcbSh) (e.g. Rewal et al., 2009, 2012; Nie et al., 2011; Leriche et al., 2008). The current study aimed to investigate the role of GABAB receptors in the AcbSh by examining the ability of two different enantiomers of baclofen to alter ethanol and saccharin intake in male C57BL/6J (B6) mice. B6 mice underwent bilateral cannulation surgery targeting the AcbSh. After 48 hours of recovery time, animals began a five day Drinking-in-the-Dark (DID) procedure where they received 20% ethanol or 0.2% saccharin for two hours, three hours into the dark cycle, each day. Throughout the five drinking sessions, animals were kept in home-cage locomotor activity chambers to monitor activity throughout the drinking cycle. Day 4 drinking was immediately preceded by a mock microinjection, whereas Day 5 drinking was immediately preceded by a drug microinjection. Microinjection of one of five doses of baclofen was given in ng/side dissolved in 200 µl of aCSF (aCSF alone, 0.02 R(+)-, 0.04 R(+)-, 0.08 S(-)-, or 0,16 S(-)-). Intake was recorded every twenty minutes on Days 4 and 5. Retro-orbital sinus blood samples were taken from ethanol animals immediately following the Day 5 drinking period to determine blood ethanol concentrations (BECs). A one-way ANOVA on total Day 4 ethanol consumption revealed no baseline differences between dose groups. A one-way ANOVA on total Day 5 ethanol consumption revealed that the 0.04 R(+)- baclofen dose reduced total drinking, but the 0.16 S(-)- baclofen dose increased total drinking (p’s<0.05). This pattern was reflected in the BECs; 0.04 R(+)- baclofen reduced BECs, whereas 0.16 S(-)- baclofen increased BECs (p’s<0.05). These results were also time-dependent, with R(+)-baclofen reducing drinking in the first 20 minutes of the session and S(-)- increasing drinking in the last 40 minutes of the session. There were no effects on saccharin intake. An issue with the locomotor activity boxes led to unreliable locomotor activity counts. However, because there were no drug effects on saccharin consumption, it was concluded that locomotor effects did not contribute to the decreases or increases in ethanol consumption. These results further implicate the role of GABAB receptors in modulating ethanol intake. The bidirectional effects shown highlight the importance of considering enantioselective drug effects when interpreting data. Finally, these results also support previous conclusions that the AcbSh plays an important role in modulating use of drugs of abuse, but not other reinforcers.
Bauer, Meredith R. "A Single Alcohol Pre-exposure Alters Dorsolateral Striatal AMPA Receptor Dependent Binge and Compulsive-like Drinking." Thesis, 2020. http://hdl.handle.net/1805/24766.
Повний текст джерелаBackground Compulsive alcohol drinking is a defining characteristic of alcohol use disorder and the dorsolateral striatum (DLS) is implicated in regulating this inflexible behavior. AMPA receptors have been implicated in both goal-directed (dorsomedial striatal dependent) and DLS dependent inflexible behaviors with antagonism in the DLS and general DLS inhibition altering inflexible behavior including habit and compulsion. Discrepancies exist in the preclinical models used to investigate compulsive-like alcohol. The purpose of these experiments was to establish a robust model of compulsive-like quinine adulterated alcohol (QuA) drinking in C57BL/6J male and female mice, assess associated AMPA receptor protein expression in the dorsal striatum, and to antagonize DLS AMPA receptors during compulsive-like QuA drinking using a model of binge-like alcohol drinking, Drinking-in-the-Dark (DID). Methods In aim 1, C57BL/6J mice were allowed free access to 20% (v/v) alcohol (alcohol history), or water (water history) for two hours each day beginning three hours into the dark cycle for 23 days. On days 15 and 22 mice were given QuA to test for compulsive-like QuA drinking. 24-hours following the last DID session brain slices were taking for DLS and DMS AMPA receptor western blot. In aim 2, C57BL/6J mice were given a total of 21 days alcohol history, to establish a compulsive-like phenotype, or water history, prior to infusion. On days 22 and 24 mice were given a bilateral infusion of one of three concentrations of NBQX, an AMPA receptor antagonist, into the DLS, immediately prior to DID where the DID solution was either alcohol or QuA. Results We found that three weeks, not two, is sufficient to produce robust compulsive-like QuA drinking in C57BL/6J mice. We failed to replicate our compulsive-like DID model in aim 2 and found that infusion of NBQX reduced 2-hour alcohol drinking and reduced 2-hour QuA drinking when QuA was the second solution presented on infusion days in male water history mice only. We also found that NBQX reduced 20-minute front-loading in female alcohol history mice on alcohol intake and trended toward QuA intake. Overall locomotor activity was affected by drug infusions. Conclusions Together, these data suggest that compulsive-like alcohol drinking can be achieved following three-weeks DID and DLS infusion of NBQX reduces both alcohol and QuA drinking in a sex and drinking history dependent way, and these effects may be reliant on an initial single QuA or alcohol exposure.
Ângelo, Alexandra Antunes. "Study of neuroinflammation markers in the hippocampus of adolescent rats after binge-like ethanol exposure." Master's thesis, 2017. http://hdl.handle.net/10451/35902.
Повний текст джерелаO início do consumo de álcool ocorre tipicamente durante a adolescência e os modos de consumo produzem efeitos visíveis a nível social e de saúde. A adolescência é um período de vida durante o qual ocorrem importantes processos do desenvolvimento cerebral, tendo sido previamente demonstrado que o cérebro adolescente é mais susceptível ao comprometimento da memória e danos cerebrais induzidos pelo etanol, pelo que o consumo excessivo de álcool pode gerar níveis neurotóxicos de intoxicação e ao desenvolvimento de efeitos profundos no sistema nervoso central. Estudos previamente realizados no laboratório GRAP demonstraram que uma exposição ao álcool do tipo binge-drinking através da administração de duas injecções consecutivas de etanol (3g/kg i.p.) em ratos foi suficiente para originar a abolição da plasticidade sináptica na região CA1 do hipocampo, bem como perdas nas habilidades de aprendizagem. Dada a relação recentemente descoberta entre a plasticidade sináptica e neuroinflamação, pretende-se agora investigar se este protocolo de exposição do tipo binge-drinking será capaz de provocar eventos neuroinflamatórios nas subregiões CA1 e Dentate Gyrus do hipocampo, utilizando dois marcadores de neuroinflamação, HMGB1 (High-mobility group box 1 protein) e TLR4 (Toll-like receptor). Os resultados do protocolo de imunohistoquímica realizado para HMGB1 revelaram que não existe diferenças estatisticamente significativas da expressão de HMGB1 entre o grupo de ratos submetidos à exposição do tipo binge-drinking e o grupo de controlo, o que sugere que a exposição excessiva ao etanol não altera a expressão de HMGB1, nem induz a ocorrência de fenómenos inflamatórios nas células neuronais, em nenhuma das subregiões do hipocampo em estudo. O estudo de imunofluorescência realizado revelou a ocorrência de um aumento da expressão de TLR4 nas duas subregiões do hipocampo em estudo dos ratos sujeitos à administração de álcool. Estes resultados sugerem que este protocolo do tipo binge-drinking parece ser suficiente para induzir fenómenos de neuroinflamação no hipocampo dos ratos.
The initiation of alcohol consumption typically occurs during adolescence and the patterns of drinking have an effect on health and social outcomes. The adolescence is a period of life, during which strong processes of brain development take place, having been previously demonstrated that adolescent brain is more susceptible to ethanol-induced memory impairment or brain damage, whereby excessive alcohol consumption may drive to neurotoxic levels of intoxication and to the development of profound effects on the central nervous system. Previous studies performed in GRAP laboratory demonstrated that binge-like ethanol exposure with two close injections of ethanol (3g/kg i.p.) in rat was enough to produce synaptic plasticity abolition in the CA1 of hippocampus, together with losses in learning abilities. Given the recently discovered relation between synaptic plasticity and neuroinflammation, we intended in this work to investigate whether this binge-like exposure protocol would be able to produce neuroinflammatory events in the CA1 field and Dentate Gyrus of the hippocampus, using two neuroinflammation markers, HMGB1 (High-mobility group box 1 protein) and TLR4 (Toll-like receptor). The results of the immunohistochemistry experiment performed for HMGB1 revealed that there are no statistically significant differences between the HMGB1 expression in group of rats exposed to the binge-drinking and the control group, which suggest that the binge-like ethanol exposure doesn't alter the HMGB1 expression and it doesn’t induce inflammatory phenomena in neurons, neither in CA1 nor Dentate Gyrus. The immunofluorescent study performed revealed an increase of TLR4 expression in both hippocampus subregions of binged rats, which suggests that this binge-like ethanol exposure protocol seems to be sufficient to induce neuroinflammation in the hippocampus of rats.
Melón, Laverne C. "Does binge drinking induce PMDD-like dysfunction for female C57BL/6J mice? : implications for sex differences in addiction vulnerability." Thesis, 2014. http://hdl.handle.net/1805/6019.
Повний текст джерелаIt has traditionally been posited that women show a "telescoped" development of alcohol use disorders (Kuhn, 2011). In particular, a number of clinical studies support striking sex differences in the progression from initial use of alcohol to dependence on the compound; with women showing a faster progression through landmark events associated with the development of alcohol addiction (Randall et al., 1999). However, recent studies have challenged this tenet (Keyes et al., 2010). The work presented herein was designed to determine whether females are indeed more vulnerable to the development of behavioral maladaptations following binge drinking and whether sex differences in GABA(A) receptor regulation might underlie this vulnerability. Using a mouse model of binge drinking this dissertation established that, compared to males, females escalate their binge drinking at a faster rate and maintain altered responsivity to the locomotor effects of alcohol after extended abstinence from binge drinking. Female mice also displayed significant increases in ethanol preference and intake in a continuous, two-bottle choice protocol following a shorter history of binge drinking than males. The final goal was to determine if binge drinking results in unique patterns of anxiety- or depressive-like symptoms in males and females and whether these behaviors would be associated with the dimorphic regulation of GABAA receptor subunits across the prefrontal cortex and hippocampus. Male binge drinkers displayed anxiety-like behavior during early withdrawal that dissipated after 2 weeks of abstinence. There were no significant changes in the expression of delta or gamma2 GABAA receptor subunit mRNA at this time point in the regions analyzed. Females also showed temporary anxiety-like behavior during early withdrawal from binge drinking. Additionally, females displayed significant depressive-like behavior after 2 weeks of abstinence from binge drinking. In particular, diestrus-phase females displayed significantly greater immobility in the forced-swim test after ethanol exposure and no longer maintained the reduced swim-time behavior associated with this phase of the cycle at baseline (when compared to the estrus-phase). qPCR analysis of hippocampal tissues from diestrus females supported a significant reduction in expression of gamma2 GABA(A) subunit mRNA after binge drinking. This effect was not noted for RNA isolated from hippocampal tissues taken during the estrus phase of bingers. These final data suggest possible interaction of estrous-cycle and binge drinking history that may result in the unique expression of deficits following binge drinking for females. Taken together, this work supports sex and estrous dependent effects of binge drinking on behavior and gene regulation.
Fritz, Brandon Michael. "Investigating the role of extrasynaptic GABAA receptors located in the infralimbic cortex in the binge-like alcohol intake of male C57BL/6J mice." Thesis, 2013. http://hdl.handle.net/1805/3694.
Повний текст джерелаExtrasynaptic GABAA receptors, often identified as those containing both α4 and δ subunits, appear to be a target for the actions of alcohol (ethanol) at relatively low concentrations, perhaps suppressing the activity of GABAergic interneurons which regulate activity in the mesolimbocortical circuit. Pharmacological studies in rodents using the δ-subunit selective agonist Gaboxadol (THIP) have found both promotional and inhibitory effects on alcohol consumption. The goal of this project was to determine the role of extrasynaptic GABAA receptors located in the infralimbic cortex (ILC) in the binge-like alcohol intake of male C57BL/6J (B6) mice. The ILC is of interest due to its demonstrated involvement in stress reactivity and alcohol exposure has been shown to interfere with extinction learning; impairments of which may be related to inflexible behavior (i.e. problematic alcohol consumption). Adult male B6 mice were bilaterally implanted with stainless steel guide cannulae aimed at the ILC and were offered limited access to 20% ethanol or 5% sucrose for 6 days. On day 7, mice were bilaterally injected with 50 or 100 ng THIP (25 or 50 ng per side respectively) or saline vehicle into the ILC. It was found that the highest dose of THIP (100 ng/mouse) increased alcohol intake relative to vehicle controls, although control animals consumed relatively little ethanol following infusion. Furthermore, THIP had no effect on sucrose consumption (p > 0.05), suggesting that the effect of THIP was selective for ethanol consumption. Together, these findings suggest that the mice that consumed ethanol may have been particularly reactive to the microinfusion process relative to animals that consumed sucrose, perhaps because ethanol consumption was not as reinforcing as sucrose consumption. In addition, the observation that THIP effectively prevented the decrease in ethanol intake on day 7 induced by the microinjection process may be related to a role for the ILC in adaptive learning processes, which in turn, promote behavioral flexibility.
Частини книг з теми "Binge-like drinking"
Krieg, Dana B., and Anna K. Krause. "Drinking Like a Man: How Gender Norms Influence College Students’ Perceptions of Binge Drinkers." In Discourses on Gender and Sexual Inequality, 91–113. Emerald Publishing Limited, 2017. http://dx.doi.org/10.1108/s1529-212620170000023005.
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