Дисертації з теми "Binding and catalysis"
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DeChancie, Jason M. "Computational design of new enzyme catalysts and investigations of biological catalysis and binding." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1619413221&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Повний текст джерелаBrackett, David Michael. "Ligand binding and catalysis in an RNA aptamer /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2005. http://uclibs.org/PID/11984.
Повний текст джерелаDervan, Joe Jude. "Substrate binding and catalysis by T5 5' nuclease." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392925.
Повний текст джерелаYu, Junru. "Ligand Binding and Catalysis in Selected Sirtuin Isozymes." Diss., North Dakota State University, 2016. http://hdl.handle.net/10365/25733.
Повний текст джерелаNIH (GM110367)
NSF (DMR1306154)
Kelly, Bernard Thomas. "Development of In vitro selections for binding and catalysis." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621351.
Повний текст джерелаZhang, Hu. "Engaging Chiral Cationic Intermediates by Anion-Binding in Asymmetric Catalysis." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718738.
Повний текст джерелаChemistry and Chemical Biology
Xu, Chongsong. "Development of functionalized spiroligomers for metal-binding and asymmetric catalysis." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/595512.
Повний текст джерелаPh.D.
This thesis describes the synthesis of functionalized spiroligomers and their applications in metal binding, metal-mediated catalysis, and organocatalysis. By synthesizing a family of functionalized bis-amino acids achieved from reductive alkylation, the Schafmeister group has developed access to highly functionalized and shape programmable structures named “spiroligomers.” The rigid backbones of spiroligomers are good at organizing the orientations of functional groups on their side chains. This property enables them as promising candidates for catalysts. Firstly we synthesized a few spiroligomer dimers presenting metal-binding groups such as terpys and bipys. With the right orientation of metal binding groups controlled by adjusting the stereocenter of the spiroligomer, macrocyclic “square” complexes with metals were obtained. The crystal structures of these intriguing complexes were solved. This work rendered the first structurally, spectroscopically and electronically characterized metal-spiroligomer complexes as well as the first crystal structure of spiroligomer. Secondly, the question of whether metal-binding spiroligomers are able to catalyze certain reactions became our major concern. We developed a binuclear copper catalyst that could accelerate a phosphate ester rearrangement, and that demonstrated that when the two copper binding terpyridine groups were best able to approach each other, they accelerated the rearrangement more than 1,000 times faster than the background reaction. Other molecules that did not properly organize the two copper atoms demonstrate considerably slower reaction rates. At last, catalysts based on spiroligomers without metals are also of interests. By displaying two hydrophobic groups in various directions on a monomeric spiroligomer (also can be regarded as a proline derivative), we observed variable activities and enantioselectivities in the catalysis of asymmetric Michael addition (up to 94% ee at -40 °C for one organocatalyst).
Temple University--Theses
Keffer-Wilkes, Laura Carole. "Substrate binding and catalysis by the pseudouridine synthases RluA and TruB." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistry, c2012, 2012. http://hdl.handle.net/10133/3253.
Повний текст джерелаxi, 122 leaves : ill. (some col.) ; 29 cm
Zhou, Min. "Understanding non-covalent interactions : cooperativity in ligand binding and enzyme catalysis." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615013.
Повний текст джерелаKimani, Serah. "Catalysis, substrate binding and specificity in the amidase from Nesterenkonia species." Doctoral thesis, University of Cape Town, 2011. http://hdl.handle.net/11427/10837.
Повний текст джерелаLuisi, Immacolata. "Identification of novel protein scaffolds for small molecules binding and for catalysis." Doctoral thesis, Università degli studi di Trieste, 2012. http://hdl.handle.net/10077/7364.
Повний текст джерелаProtein scaffolds are stable structures capable to recognize and bind, in different conditions, small guest molecules. They are proteins with known conformation which can be used and modified for the construction of variants. The goal of this work is the identification of peptide-based artificial receptors or catalysts. To this purpose, we have considered two different protein motifs to generate new scaffolds: a synthetic E/K coiled-coil domain, and one of the binding sites of the natural protein Human serum albumin. In order to generate stable peptide hosts, we developed peptide libraries to be selected for both properties, adopting two different approaches: RANDOM mutagenesis and SITE-DIRECTED mutagenesis.
XXIV Ciclo
1985
McGrath, Jacqueline. "Advances in Supramolecular Catalysis: Studies of Bifurcated Hamilton Receptors." Thesis, University of Oregon, 2016. http://hdl.handle.net/1794/19691.
Повний текст джерелаVeitch, Dallas P. "Characterisation of the catalytic domain of CTP:phosphocholine cytidylyltransferase, the role of the HXGH motif in catalysis and substrate binding." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ37764.pdf.
Повний текст джерелаQamar, Seema. "Substrate binding and catalysis in the Class II FBP-aldolase from Escherichia coli." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627079.
Повний текст джерелаStovold, Caroline P. "An ion-binding approach to asymmetric allylation reactions." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:1dc96ffb-f079-4b7a-847e-5d2fb792caf9.
Повний текст джерелаNotenboom, Valerie. "Crystallographic studies of carbohydrate modifying proteins, mechanisms of action in polysaccharide binding and catalysis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0023/NQ49935.pdf.
Повний текст джерелаLee, Hyelee. "Site-Selective Reactions Via Scaffolding Catalysis & Synthesis and Binding Study of 1,2-Azaborines." Thesis, Boston College, 2017. http://hdl.handle.net/2345/bc-ir:107562.
Повний текст джерелаThesis advisor: Shih-Yuan Liu
Chapter 1. In the Tan laboratory, we developed synthetic methods to control reaction selectivity (regio-, stereo-, and site-selectivity) using scaffolding catalysis. Our strategy utilizes directing groups that induce intramolecularity through the formation of a labile covalent bond between the substrate and a binding site in a catalytic system. In the first part, we described site-selective functionalization of various carbohydrates and complex polyhydroxylated molecules which contain cis-1,2-diol motif using a chiral organic scaffold. In the second part, meta-selective C–H functionalization of arenes was demonstrated. High meta-selectivity was achieved by the use of a nitrile-based silyl tether which is cleavable and recyclable. Chapter 2. In the Liu laboratory, we focuses on studies of boron-nitrogen containing heterocycles. In this chapter, synthesis of 1,2-azaborines and their binding study with T4 lysozyme mutants were described. Specifically, we directly compared binding of NH-containing 1,2-azaborines and their carbonaceous analogs to probe hydrogen bonding interaction between the NH group of azaborine and a carbonyl oxygen of protein residue. Structural and thermodynamic analysis provided us the first evidence of H-bonding of azaborines with a biological macromolecule. Chapter 3. Described are the synthesis of regioisomers of ethyl-substituted 1,2-azaborines and their binding thermodynamics to T4 lysozyme mutants. To access the azaborine ligands used in the binding study, we developed synthetic methods for regioselective functionalization of six positions of 1,2-azaborines. Isothermal titration calorimetry experiments showed differences in binding free energy for regioisomers to the L99A T4 lysozyme. This result could originate from electronic differences of the isosteric ligands inducing dipole-dipole interaction between ligand and surrounding protein residues or it may be from local dipolar interactions. Chapter 4. A general method for late-stage N-functionalization of 1,2-azaborines is described to afford libraries of BN-containing complex molecules. The chemical transformations include electrophilic substitution reactions, N–C(sp2) bond forming reactions under Buchwald-Hartwig amination conditions, and N–C(sp) bond forming reactions using copper-catalyzed N-alkynylation. As applications in materials science and medicinal chemistry, synthesis of the first parental BN isostere of trans-stilbene and lisdexamfetamine derivative is described utilizing the methodology developed in this work
Thesis (PhD) — Boston College, 2017
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Chemistry
Zhu, Genhai. "Rubisco: Characteristics of misfire during catalysis and the properties of the substrate binding sites." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185734.
Повний текст джерелаSakipov, Serzhan, Olga Rafikova, Maria G. Kurnikova, and Ruslan Rafikov. "Molecular mechanisms of bio-catalysis of heme extraction from hemoglobin." ELSEVIER SCIENCE BV, 2017. http://hdl.handle.net/10150/624355.
Повний текст джерелаFischer, Theresa [Verfasser], and Mancheño Olga [Akademischer Betreuer] García. "Enantioselective Nucleophilic Dearomatization of Heteroarenes by Anion-Binding-Catalysis / Theresa Fischer ; Betreuer: Olga García Mancheño." Regensburg : Universitätsbibliothek Regensburg, 2019. http://d-nb.info/1180719484/34.
Повний текст джерелаEngle, Keary Mark. "Ligand-accelerated catalysis in palladium(II)-mediated C-H functionalisation ; Hydrogen bonding effects on the reactivity of fluoride anion." Thesis, University of Oxford, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711664.
Повний текст джерелаLin, Song. "Elucidation of the Cation−π Interaction in Small-Molecule Asymmetric Catalysis." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11132.
Повний текст джерелаChemistry and Chemical Biology
Gupta, Ruchi. "Characterizing the Roles of Exit Tunnel Residues in Ligand Binding and Catalysis of Histone Deacetylase-8." Thesis, North Dakota State University, 2014. https://hdl.handle.net/10365/27513.
Повний текст джерелаSoebbing, Samantha Lynn. "Incorporation of histidine-rich metal-binding sites onto small protein scaffolds implications for imaging, therapeutics, and catalysis /." Diss., University of Iowa, 2008. http://ir.uiowa.edu/etd/37.
Повний текст джерелаAl-Khatib, Haifa Yousef. "Site Directed Mutagenesis of Dienelactone Hydrolase." Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc277940/.
Повний текст джерелаMarolt, Marija [Verfasser], and Steffen [Akademischer Betreuer] Lüdeke. "The role of NAD(P)H cofactor binding in alcohol dehydrogenase catalysis = Die Rolle der Bindung des Cofaktors NAD(P)H für die Alkoholdehydrogenase-Katalyse." Freiburg : Universität, 2018. http://d-nb.info/1185438718/34.
Повний текст джерелаOwens, Samuel Britt. "Transition metal complexes of bis(phosphorus) donor ligands derived from multifunctional diols synthesis, isomerization, cation binding, and catalysis /." Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/owens.pdf.
Повний текст джерелаAdditional advisors: Houston Byrd, Chris Lawson, Sadanandan Velu, Charles Watkins. Description based on contents viewed Feb. 9, 2009; title from PDF t.p. Includes bibliographical references.
Herdendorf, Timothy J. Miziorko Henry M. "Phosphomevalonate kinase investigation of the recombinant human enzyme and identification of key residues involved in substrate binding and catalysis /." Diss., UMK access, 2007.
Знайти повний текст джерела"A dissertation in molecular biology and biochemistry and cell biology and biophysics." Advisor: Henry M. Miziorko. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed Sept. 12, 2008. Includes bibliographical references (leaves 109-126). Online version of the print edition.
Okafor, Chiamaka Denise. "Metallobiochemistry of RNA: Mg(II) and Fe(II) in divalent binding sites." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/53904.
Повний текст джерелаVisco, Michael David. "Chiral Silanediols Designed for Enantioselective Heterocycle Functionalization." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492438099945523.
Повний текст джерелаErat, Michèle Christine. "Two domains of branching and catalysis act as specific metal ion binding platforms within the group II intron ribozyme core /." Zürich, 2007. http://opac.nebis.ch/cgi-bin/showAbstract.pl?u20=9783952338100.
Повний текст джерелаParry, Damian. "Restriction endonuclease EcoRV : use of base analogues to investigate catalysis and binding employing single turn-over kinetics and fluorescent techniques." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263130.
Повний текст джерелаBirrell, James Andrew. "I. Enantioselective Acylation of Silyl Ketene Acetals through Fluoride Anion-Binding Catalysis II. Development of a Practical Method for the Synthesis of Highly Enantioenriched Trans-1,2-Amino Alcohols." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11037.
Повний текст джерелаChemistry and Chemical Biology
Sanders, Charles Ray. "Examination of the relationship of substrate dynamics to enzymic structure, binding energy, and catalysis: NMR studies of adenosine 5'-triphosphate and adenylate kinase /." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487597424137198.
Повний текст джерелаSubramaniam, Srisunder. "Studies of conformational changes and dynamics accompanying substrate recognition, allostery and catalysis in bacteriophage lambda integrase." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1111655332.
Повний текст джерелаCastellani, Michela [Verfasser], Bernd [Akademischer Betreuer] Ludwig, and Klaas Martinus [Akademischer Betreuer] Pos. "Substrate binding does not only mean catalysis: internal regulation in the cytochrome bc1 complex from Paracoccus denitrificans / Michela Castellani. Gutachter: Bernd Ludwig ; Klaas Martinus Pos." Frankfurt am Main : Univ.-Bibliothek Frankfurt am Main, 2011. http://d-nb.info/104419510X/34.
Повний текст джерелаCazzolaro, Alessandro. "Monostrati organici supportati su nanoparticelle d'oro per catalisi e riconoscimento molecolare." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423809.
Повний текст джерелаNel corso dei decenni le nanoparticelle dâ'oro si sono dimostrate supporti estremamente attraenti per la realizzazione di sistemi ibridi inorganici-organici, sfruttando l'interazione stabile che si crea tra superfici d'oro e particolari classi di molecole organiche (come ammine, fosfonati o tioli) per formare monostrati autoassemblati.[1] Questo tipo di sistemi è stato sfruttato ampiamente per una vasta gamma di applicazioni, tra cui spicca la realizzazione di catalizzatori organici nano-supportati. La motivazione dietro lâinteresse verso le nanoparticelle d'oro per applicazioni catalitiche risiede nella versatilità della realizzazione del monostrato, virtualmente applicabile ad ogni tipo di reazione catalizzata da molecole organiche, e dall'enorme rapporto superficie/volume dei colloidi d'oro.[2] In un recente lavoro di Prins et al.[3], impiegando un sistema catalitico ideato da Scrimin et al. per lâidrolisi di fosfodiesteri[4], si utilizzano nanoparticelle d'oro di 2 nm di diametro che espongono complessi di 1,4,7-triazaciclononano-Zn(II) come effettori di uno strumento di sensing per enzimi proteolitici. Tale sistema si basa sullâinibizione della reazione di transfosforilazione di HPNP (2-idrossipropil-4-nitrofenil fosfato) promossa dalle nanoparticelle ed osservabile per via spettrofotometrica seguendo la liberazione della molecola reporter p-nitrofenato, dovuta all'interazione tra la nanoparticella d'oro e oligopeptidi carichi negativamente. L'oligopeptide agisce nel doppio ruolo di inibitore della nanoparticella e di substrato enzimatico, regolando il sistema dipendentemente dalla presenza o meno di un enzima in grado di degradarlo in frammenti a carica inferiore che non inibiscono efficacemente la nanoparticella. Lâinteresse verso il perfezionamento di tale sistema ha spinto allo studio discusso in questo elaborato di tesi, utilizzando la catalisi della transfosforilazione di HPNP e la capacità di interazione con oligoanioni come strumenti diagnostici di monostrati organici analoghi. Lo studio ha portato alla sintesi di tre building blocks organici, in cui il residuo tiolico e il macrociclo sono separati da catene alchiliche di diverse lunghezze (6, 9, 12 atomi di carbonio). In prima analisi viene discussa la sintesi e caratterizzazione di nanoparticelle dâoro passivate con i tre tioli (C6TACN, C9TACN, C12TACN), in cui si evidenziano poche differenze in termini qualitativi tra Au NPs C9TACN e Au NPs C12TACN. Au NPs C6TACN dimostrano un monostrato più¹ densamente popolato, probabilmente dovuto ad interazione laterali reciproche più efficenti tra i tioli all'interno del monostrato. La valutazione della catalisi dei tre sistemi sulla reazione modello ha evidenziato una similitudine tra Au NPs C9TACN e Au NPs C12TACN in termini di attività catalitica (kcat) ed interazione con il substrato (KM), senza discostarsi in maniera rilevante dai sistemi studiati nei lavori precedenti, dotati di un tiolo più lungo.[5] Au NPs C6TACN, nonostante mantenga pressochè inalterato kcat rispetto ai due sistemi analoghi, presenta un KM di circa tre volte più elevato, indice di interazione più debole del sistema col substrato. Al fine di studiare il processo di binding tra nanoparticella e oligoanione in maniera più ampia si è ricorso allo studio dell'interazione delle nanoparticelle sintetizzate con oligoanioni fluorescenti, sfruttando il peculiare quenching della luminescenza mediato dai core d'oro per determinare la concentrazione di saturazione del monostrato.[6] L'utilizzo di un primo probe fluorescente (fATP), in cui l'interazione con la nanoparticella è mediato in larga misura da carica elettrostatica, ha evidenziato differenze minime tra i tre diversi campioni. Utilizzando un probe (MANT-AMP) in cui vi è un bilancio tra interazione elettrostatica (con la superfice del monostrato) ed idrofobica[7] (con la parte alchilica interna del monostrato) si sono evidenziate differenze sostanziali tra Au NPs C6TACN e Au NPs C9TACN. Tale esperimento è risultato in una assenza di quenching per Au NPs C12TACN, verificando l'avvenuto binding con un esperimento di displacement indipendente. Il fenomeno è ritenuto imputabile ad un orientamento sfavorevole al quenching del probe nel monostrato. Lavorando in assenza di Zn(II) e a pH nettamente basico al fine di mantenere il monostrato privo di carica, si è potuto osservare una totale assenza di interazione tra MANT-AMP e Au NPs C6TACN, confermando come la differente natura del monostrato giochi un ruolo nell'interazione con molecole organiche che va al di là dell'interazione elettrostatica, riscontrabile anche nell'interazione con il substrato catalitico. Questo effetto, seppur sicuramente attribuibile a differenze nella struttura del building block componente il monostrato, può essere dovuto sia al diverso spessore del monostrato sia alla particolare densità del monostrato stesso per Au NPs C6TACN. Le performances catalitiche e di binding per oligoanioni dei tre sistemi sono state testate in un arco di tempo di 4 mesi per stabilire quale sistema mantenesse tali parametri nel tempo, allo scopo di ottenere informazioni sulla stabilità dei tre sistemi. Tutti i sistemi si sono rivelati relativamente ben stabili nel tempo, senza dimostrare aggregazione o deterioramento consistente dei parametri osservati. Au NPs C9TACN, contrariamente ai sistemi analoghi, non ha dimostrato alcuna variazione apprezzabile nei valori osservati, confermandosi il sistema più robusto. In ultima analisi è stato preso in considerazione il ruolo delle dimensioni della nanoparticella nell'evento catalitico. La sintesi e caratterizzazione di un sistema composto da nanoparticelle di 13 nm di diametro e passivato da tiolo C9TACN ha permesso di confrontarne le performance catalitiche con quelle del sistema analogo utilizzato nello studio precedente. I risultati dimostrano come il sistema sia ancora cataliticamente attivo, con un netto peggioramento dell'attività catalitica e del binding del substrato rispetto all'analogo supportato su nanoparticelle di diametro 2 nm. Questi risultati possono essere imputati alla mancanza di "hot spot" catalitici presenti in nanoparticelle piccole e con curvature accentuate.
Sperandio, Céline. "Développement de nouvelles plateformes polyols halogénés et étude de leurs propriétés supramoléculaires." Electronic Thesis or Diss., Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0556.
Повний текст джерелаIn the actual context of green chemistry, it is of prime importance for organic chemists to develop new eco-compatible synthetic methodologies. These new approaches are fundamental to be able to modulate the molecular properties enabling the design of new materials, drugs or chemical processes. In Nature, 1,3-polyols are essential motifs for the biological activity of many natural products. During this PhD, we have thoroughly studied the influence of halogen insertion in polyols over supramolecular properties.The first part of our work has consisted in the synthesis of polyols possessing two different halogenohydrin motifs. We have then been able to highlight the importance of this motif triggering considerable increase of their supramolecular properties based on H-bonding networks (anion coordination, self-assembly, catalysis). In a second part, we have further strengthen the central H-bonding framework through insertion of lateral perfluorinated chains. The preparation of these new 1,3,5-triols scaffolds was possible thanks to the development of an original copper catalyzed bi-directional aldolization. These new perfluorinated triols were excellent platforms for selective anion binding notably chiral recognition as well as catalysis and for the elaboration of non-covalent materials such as organogelators
Ciardi, Moira. "Design, synthesis and binding studies of calix(4)pyrrole based receptors suitable for ion-pair complexation and n-oxide recognition. Synthesis of resorcin(4) arene derivatives as potential ligands for supramolecular catalysis." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/90244.
Повний текст джерелаThe work developed during the PhD thesis deals mainly with the design and synthesis ofSupramolecular Hosts. In particular, we present new aryl-extended calix[4]pyrroleswith two or four phosphonate groups as heteroditopic receptors for the complexation of ion-pairs and that result important for the extraction of salts and for the transportof ions through membranes. Likewise, derivativesofcalix[4]pyrroles have been prepared for the selective inclusionofN-oxides in high energy conformation.The importance of the inclusion has been demonstrated by the change of the reactivity of the N-oxide in reactions in which it is commonly used as co-catalyst. Finally, we present derivatives ofresorcin[4]arenes with ethyl groups at the lower rim of thereceptor and a mobile wall in the upper rim as potential ligands for Supramolecular catalysis.
Persson, Per. "Strategies for cellulose fiber modification." Doctoral thesis, KTH, Fibre and Polymer Technology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3730.
Повний текст джерелаThis thesis describes strategies for and examples ofcellulose fiber modification.The ability of an engineered biocatalyst, acellulose-binding module fused to theCandida antarcticalipase B, to catalyze ring-openingpolymerization of e-caprolactone in close proximity tocellulose fiber surfaces was explored. The water content in thesystem was found to regulate the polymer molecular weight,whereas the temperature primarily influenced the reaction rate.The hydrophobicity of the cellulose sample increased as aresult of the presence of surface-deposited polyester.
A two-step enzymatic method was also investigated. Here,Candida antarctica lipase B catalyzed the acylation ofxyloglucan oligosaccharides.The modified carbohydrates werethen incorporated into longer xyloglucan molecules through theaction of a xyloglucan endotransglycosylase. The modifiedxyloglucan chains were finally deposited on a cellulosesubstrate.
The action ofCandida antarcticalipase B was further investigated inthe copolymerization of e-caprolactone and D,L-lactide.Copolymerizations with different e-caprolactone-to-D,L-lactideratios were carried out. Initially, the polymerization wasslowed by the presence of D,L-lactide. During this stage,D,L-lactide was consumed more rapidly than ε-caprolactoneand the incorporation occurred dimer-wise with regard to thelactic acid units.
Morphological studies on wood fibers were conducted using asol-gel mineralization method. The replicas produced werestudied, without additional sample preparation, by electronmicroscopy and nitrogen adsorption. Information concerning thestructure and accessibility of the porous fiber wall wasobtained. Studies of never-dried kraft pulp casts revealedmicro-cavities and cellulose fibrils with mean widths of 4.7(±2) and 3.6 (±1) nm, respectively.
Finally, cationic catalysis by simple carboxylic acids wasstudied. L-Lactic acid was shown to catalyze the ring-openingpolymerization of ε-caprolactone in bulk at 120 °C.The reaction was initiated with methylß-D-glucopyranoside, sucrose or raffinose, which resultedin carbohydrate-functionalized polyesters. The regioselectivityof the acylation was well in agreement with the correspondinglipase-catalyzed reaction. The polymerization was alsoinitiated with a hexahydroxy-functional compound, whichresulted in a dendrimer-like star polymer. The L-lactic acidwas readily recycled, which made consecutive reactions usingthe same catalyst possible.
Keywords:Candida antarcticalipase B, cationic catalysis,cellulose-binding module, dendrimer, enzymatic polymerization,fiber modification, silica-cast replica, sol-gelmineralization, organocatalysis, xyloglucanendotransglycosylase
Bolam, David Nichol. "The functional analysis of catalytic and non-catalytic domains in glycosyl hydrolases." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297498.
Повний текст джерелаSchafer, Andrew Gerard. "Silanediols As Hydrogen Bond Donor Catalysts." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1396442513.
Повний текст джерелаMcDonald, Rhona E. "Using a binding protein as a scaffold for designer catalysts." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403419.
Повний текст джерелаRoychowdhury-Saha, Manami. "Ribonucleic acid architecture dictates its binding and catalytic properties." [Bloomington, Ind.] : Indiana University, 2005. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3204290.
Повний текст джерелаSource: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0253. Adviser: Donald H. Burke. "Title from dissertation home page (viewed Feb. 9, 2007)."
Jones, Caroline L. "Pterin biosynthesis, binding and modulation of eNOS catalytic function." Thesis, University of Surrey, 2000. http://epubs.surrey.ac.uk/843904/.
Повний текст джерелаZieleniuk, Candace A. "Anion binding and catalytic studies of metal salen complexes." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0024865.
Повний текст джерела何振華 and Chun-wah Ho. "Study on osmium and manganese complexes of chiral binaphthylic tetradentate ligands and their application to asymmetric epoxidationof alkenes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31233570.
Повний текст джерелаHo, Chun-wah. "Study on osmium and manganese complexes of chiral binaphthylic tetradentate ligands and their application to asymmetric epoxidation of alkenes /." [Hong Kong : University of Hong Kong], 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13787020.
Повний текст джерелаTorrance, James William. "The geometry and evolution of catalytic sites and metal binding sites." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612125.
Повний текст джерелаShojaee, Kambiz. "Fundamental aspects of ammonia oxidation on cobalt oxide catalysts." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/13657.
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