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Статті в журналах з теми "Bcnam"
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Diallo, Chiaka, H. Frederick W. Rattunde, Vernon Gracen, Aboubacar Touré, Baloua Nebié, Willmar Leiser, Daniel K. Dzidzienyo, et al. "Genetic Diversification and Selection Strategies for Improving Sorghum Grain Yield Under Phosphorous-Deficient Conditions in West Africa." Agronomy 9, no. 11 (November 11, 2019): 742. http://dx.doi.org/10.3390/agronomy9110742.
Повний текст джерелаАнотація:
Sorghum, a major crop for income generation and food security in West and Central Africa, is predominantly grown in low-input farming systems with serious soil phosphorus (P) deficiencies. This study (a) estimates genetic parameters needed to design selection protocols that optimize genetic gains for yield under low-phosphorus conditions and (b) examines the utility of introgressed backcross nested association mapping (BCNAM) populations for diversifying Malian breeding materials. A total of 1083 BC1F5 progenies derived from an elite hybrid restorer “Lata-3” and 13 diverse donor accessions were evaluated for yield and agronomic traits under contrasting soil P conditions in Mali in 2013. A subset of 298 progenies were further tested under low-P (LP) and high-P (HP) conditions in 2014 and 2015. Significant genetic variation for grain yield was observed under LP and HP conditions. Selection for grain yield under LP conditions was feasible and more efficient than the indirect selection under HP in all three years of testing. Several of the BCNAM populations exhibited yields under LP conditions that were superior to the elite restorer line used as a recurrent parent. The BCNAM approach appears promising for diversifying the male parent pool with introgression of diverse materials using both adapted Malian breed and unadapted landrace material from distant geographic origins as donors.
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Le Sourd, Marie. "The Bandung Center for New Media Arts: Local Commitment and International Collaboration." Leonardo 39, no. 4 (August 2006): 315–18. http://dx.doi.org/10.1162/leon.2006.39.4.315.
Повний текст джерелаАнотація:
The article focuses on the Bandung Center for New Media Arts (BCNMA), an autonomous cultural space set up in 2001 by three Indonesian artists and architects. The BCNMA aims to encourage a dialogue with circles outside the art world and to offer greater dynamic possibilities for experimental forms of expressions. The Indonesian sociopolitical context after 1998 has had a great influence on the nature, development and methodologies used by this center. The case study of the Third Asia-Europe Art Camp, coorganized in 2005 by the BCNMA and the Asia-Europe Foundation, also highlights how international projects are developed by the BCNMA while taking into consideration the local cultural networks and creative environment.
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Collec, Emmanuel, Marie-Christine Lecomte, Wassim El Nemer, Yves Colin, and Caroline Le Van Kim. "Novel role for the Lu/BCAM–spectrin interaction in actin cytoskeleton reorganization." Biochemical Journal 436, no. 3 (May 27, 2011): 699–708. http://dx.doi.org/10.1042/bj20101717.
Повний текст джерелаАнотація:
Lu/BCAM (Lutheran/basal cell-adhesion molecule) is a laminin 511/521 receptor expressed in erythroid and endothelial cells, and in epithelial tissues. The RK573–574 (Arg573-Lys574) motif of the Lu/BCAM cytoplasmic domain interacts with αI-spectrin, the main component of the membrane skeleton in red blood cells. In the present paper we report that Lu/BCAM binds to the non-erythroid αII-spectrin via the RK573–574 motif. Alanine substitution of this motif abolished the Lu/BCAM–spectrin interaction, enhanced the half-life of Lu/BCAM at the MDCK (Madin–Darby canine kidney) cell surface, and increased Lu/BCAM-mediated cell adhesion and spreading on laminin 511/521. We have shown that the Lu/BCAM–spectrin interaction mediated actin reorganization during cell adhesion and spreading on laminin 511/521. This interaction was involved in a laminin 511/521-to-actin signalling pathway leading to stress fibre formation. This skeletal rearrangement was associated with an activation of the small GTP-binding protein RhoA, which depended on the integrity of the Lu/BCAM laminin 511/521-binding site. It also required a Lu/BCAM–αII-spectrin interaction, since its disruption decreased stress fibre formation and RhoA activation. We conclude that the Lu/BCAM–spectrin interaction is required for stress fibre formation during cell spreading on laminin 511/521, and that spectrin acts as a signal relay between laminin 511/521 and actin that is involved in actin dynamics.
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Kannan, Kalpana, Cristian Coarfa, Pei-Wen Chao, Liming Luo, Yan Wang, Amy E. Brinegar, Shannon M. Hawkins, Aleksandar Milosavljevic, Martin M. Matzuk, and Laising Yen. "Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma." Proceedings of the National Academy of Sciences 112, no. 11 (March 2, 2015): E1272—E1277. http://dx.doi.org/10.1073/pnas.1501735112.
Повний текст джерелаАнотація:
High-grade serous ovarian cancer (HGSC) is among the most lethal forms of cancer in women. Excessive genomic rearrangements, which are expected to create fusion oncogenes, are the hallmark of this cancer. Here we report a cancer-specific gene fusion between BCAM, a membrane adhesion molecule, and AKT2, a key kinase in the PI3K signaling pathway. This fusion is present in 7% of the 60 patient cancers tested, a significant frequency considering the highly heterogeneous nature of this malignancy. Further, we provide direct evidence that BCAM-AKT2 is translated into an in-frame fusion protein in the patient’s tumor. The resulting AKT2 fusion kinase is membrane-associated, constitutively phosphorylated, and activated as a functional kinase in cells. Unlike endogenous AKT2, whose activity is tightly regulated by external stimuli, BCAM-AKT2 escapes the regulation from external stimuli. Moreover, a BCAM-AKT2 fusion gene generated via chromosomal translocation using the CRISPR/Cas9 system leads to focus formation in both OVCAR8 and HEK-293T cell lines, suggesting that BCAM-AKT2 is oncogenic. Together, the results indicate that BCAM-AKT2 expression is a new mechanism of AKT2 kinase activation in HGSC. BCAM-AKT2 is the only fusion gene in HGSC that is proven to translate an aberrant yet functional kinase fusion protein with oncogenic properties. This recurrent genomic alteration is a potential therapeutic target and marker of a clinically relevant subtype for tailored therapy of HGSC.
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Yu, Hyunkyung, Nathalie Bellocq, Youngeun Ha, Hyunuk Kim, Yunyeon Kim, Bu-Nam Jeon, Léo Marx, et al. "Abstract 1760: The antibody-drug conjugate GENA-111 conjugated to auristatin F shows therapeutic potency in BCAM positive epithelial cancer." Cancer Research 82, no. 12_Supplement (June 15, 2022): 1760. http://dx.doi.org/10.1158/1538-7445.am2022-1760.
Повний текст джерелаАнотація:
Abstract Antibody-drug conjugates (ADCs) are considered as promising cancer treatment modalities that combine the selectivity of antibodies and the cytotoxic properties of payloads using chemical linkers. However, despite their success, ADCs still suffer from drawbacks, e.g., systemic toxicity, which limit their potential clinical applications. The systemic toxicity of an ADC is mainly related to the stability of its linker, and to the selectivity of its antibody towards the targeted antigen expressed on cancer cells. Lu/BCAM (Lutheran/basal cell adhesion molecule) is a member of the immunoglobulin superfamily and is a receptor for laminin, a protein that facilitates cell adhesion, migration, and invasion. A growing number of studies show that BCAM plays an essential role in tumor progression and is overexpressed on epithelial cancers e.g., skin cancer. Here we describe GENA-111, a human monoclonal anti-BCAM IgG4 (S228P) antibody that binds to human BCAM with high affinity, and that is significantly internalized by BCAM-positive tumor cells. We also describe the GENA-111-auristatin F ADC, wherein the GENA-111 antibody has been armed with an auristatin F derivative using a new linker technology and a stabilized thiol maleimide conjugation. This new linker technology comprises a cleavable peptidic sequence that facilitates multidrug attachment and the production of ADCs with tailored drug-to-antibody ratios (DARs). Cytotoxic drugs are rapidly and selectively released from the linker by the carboxypeptidase activity of Cathepsin B. In vitro cytotoxicity examination showed the potent cytotoxic effects of this GENA-111-auristatin F ADC on BCAM-expressing tumor cells, with a positive correlation between cytotoxicity and BCAM expression. Moreover, this ADC was also shown to significantly reduce the growth of tumor cells, including A431, T47D, and Huh7. The GENA-111-auristatin F ADC was evaluated in a xenograft mouse model established by subcutaneous injection of A431 cells, a BCAM positive human skin cancer cell line. The results of this study will be presented and discussed. Taken together, our data suggest that an ADC targeting BCAM e.g., GENA-111-auristatin F, might be a promising treatment strategy for BCAM positive epithelial cancer patients. Citation Format: Hyunkyung Yu, Nathalie Bellocq, Youngeun Ha, Hyunuk Kim, Yunyeon Kim, Bu-Nam Jeon, Léo Marx, Mathilde Pantin, Hyunjin Yoo, Seungmin Byun, Joo-Yeon Chung, Mi Young Cha, Patrick Garrouste, Frédéric Lévy. The antibody-drug conjugate GENA-111 conjugated to auristatin F shows therapeutic potency in BCAM positive epithelial cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1760.
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Rahuel, Cécile, Anne Filipe, Léa Ritie, Wassim El Nemer, Natacha Patey-Mariaud, Dominique Eladari, Jean-Pierre Cartron, Patricia Simon-Assmann, Caroline Le Van Kim та Yves Colin. "Genetic inactivation of the laminin α5chain receptor Lu/BCAM leads to kidney and intestinal abnormalities in the mouse". American Journal of Physiology-Renal Physiology 294, № 2 (лютий 2008): F393—F406. http://dx.doi.org/10.1152/ajprenal.00315.2007.
Повний текст джерелаАнотація:
Lutheran blood group and basal cell adhesion molecule (Lu/BCAM) has been recognized as a unique receptor for laminin α5chain in human red blood cells and as a coreceptor in epithelial, endothelial, and smooth muscle cells. Because limited information is available regarding the function of this adhesion glycoprotein in vivo, we generated Lu/BCAM-null mice and looked for abnormalities in red blood cells as well as in kidney and intestine, two tissues showing alteration in laminin α5chain-deficient mice. We first showed that, in contrast to humans, wild-type murine red blood cells failed to express Lu/BCAM. Lu/BCAM-null mice were healthy and developed normally. However, although no alteration of the renal function was evidenced, up to 90% of the glomeruli from mutant kidneys exhibited abnormalities characterized by a reduced number of visible capillary lumens and irregular thickening of the glomerular basement membrane. Similarly, intestine analysis of mutant mice revealed smooth muscle coat thickening and disorganization. Because glomerular basement membrane and smooth muscle coat express laminin α5chain and are in contact with cell types expressing Lu/BCAM in wild-type mice, these results provide evidence that Lu/BCAM, as a laminin receptor, is involved in vivo in the maintenance of normal basement membrane organization in the kidney and intestine.
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Karabay, Onder, Mustafa Hasbahceci, and Huseyin Kadioglu. "Impact of breast cancer awareness month on detection of breast cancer in a private hospital." Journal of International Medical Research 46, no. 2 (March 29, 2017): 619–25. http://dx.doi.org/10.1177/0300060517699988.
Повний текст джерелаАнотація:
Objective Breast cancer awareness month increases public awareness in association with increased rates of screening and new diagnoses. This study aimed to evaluate the effect of breast cancer awareness month on primary diagnosis of breast cancer. Methods Asymptomatic women with the intention of breast cancer screening were included. The non-BCAM (Breast cancer awareness month) group were screened from February to September 2016 and the BCAM group during October 2016. Ultrasound and mammography were performed in all women and in those aged ≥ 40 years, respectively. A BIRADS (Breast Imaging Reporting And Data Systems) score of ≥4 and solid palpable masses without features suggestive of malignancy and/or the physician’s preference were regarded as indications for histopathological analysis. Requirement for histopathological analysis and detection of breast cancer were identified as the main variables. Results There were 198 women with a mean age of 49.3 ± 9.5 years. Sixty-nine and 129 women were in the non-BCAM and BCAM groups, respectively. Percutaneous biopsy was performed in seven (10.1%) and three patients (2.3%) in the non-BCAM and BCAM groups, respectively ( P = 0.035). Pathological examinations were benign. Conclusion Although public awareness campaigns lead to increased rates of screening, they may lose their impact on detecting breast cancer because of widespread use of routine screening programs.
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Wautier, Marie-Paule, Wassim El Nemer, Pierre Gane, Jean-Didier Rain, Jean-Pierre Cartron, Yves Colin, Caroline Le Van Kim та Jean-Luc Wautier. "Increased adhesion to endothelial cells of erythrocytes from patients with polycythemia vera is mediated by laminin α5 chain and Lu/BCAM". Blood 110, № 3 (1 серпня 2007): 894–901. http://dx.doi.org/10.1182/blood-2006-10-048298.
Повний текст джерелаАнотація:
Abstract Patients with polycythemia vera (PV) have a JAK2 (a cytosolic tyrosine kinase) mutation and an increased risk of vascular thrombosis related to red blood cell (RBC) mass and platelet activation. We investigated functional RBC abnormalities that could be involved in thrombosis. RBC adhesion to human umbilical vein endothelial cells (HUVECs) was measured by a radiometric technique and in a flow system by video microscopy, and adhesion molecule expression was determined using specific antibodies (against CD36, CD49d, ICAM-4, Lu/BCAM, CD147, and CD47) and flow cytometry in a group of 38 patients with PV and a group of 36 healthy volunteers. Adhesion of PV RBCs was 3.7-fold higher than that of normal RBCs (P < .001). Adhesion was inhibited when PV RBCs were incubated with anti-Lutheran blood group/basal cell adhesion molecule (Lu/BCAM) or when HUVECs were treated with anti-laminin α5 and to a lesser extent with anti-α3 integrin. Lu/BCAM was constitutively phosphorylated in PV RBCs. Transfection of K562 cells with JAK2 617V>F resulted in increased expression and phosphorylation of Lu/BCAM. Phosphorylation of Lu/BCAM increases RBC adhesion. Our results indicate that JAK2 mutation might be linked to Lu/BCAM modification and increased RBC adhesiveness, which may be a factor favoring thrombosis in PV.
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Andrei, Graciela, Rebecca Sienaert, Chris McGuigan, Erik De Clercq, Jan Balzarini, and Robert Snoeck. "Susceptibilities of Several Clinical Varicella-Zoster Virus (VZV) Isolates and Drug-Resistant VZV Strains to Bicyclic Furano Pyrimidine Nucleosides." Antimicrobial Agents and Chemotherapy 49, no. 3 (March 2005): 1081–86. http://dx.doi.org/10.1128/aac.49.3.1081-1086.2005.
Повний текст джерелаАнотація:
ABSTRACT Varicella-zoster virus (VZV) is responsible for primary infections as well as reactivations after latency in the dorsal root ganglia. The treatment of such infections is mandatory for immunocompromised patients and highly recommended for elderly patients with herpes zoster infections (also called zona or shingles). The treatment of choice is presently based on four molecules, acyclovir (ACV), valaciclovir, famciclovir, and (in Europe) brivudine (BVDU). We present here our data on the antiviral activity of a new class of potent and selective anti-VZV compounds, bicylic pyrimidine nucleoside analogues (BCNAs), against a broad variety of clinical isolates and different drug-resistant virus strains. The results show that the BCNAs are far more potent inhibitors than ACV and BVDU against clinical VZV isolates as well as the VZV reference strains Oka and YS. The BCNAs were not active against ACV- and BVDU-resistant VZV strains bearing mutations in the viral thymidine kinase gene but kept their inhibitory potential against virus strains with mutations in the VZV DNA polymerase gene. Mutant virus strains selected in the presence of the BCNAs were solely cross-resistant to drugs, such as ACV and BVDU, that depend for their antiviral action on metabolic activation by the viral thymidine kinase.
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Klei, T. R. L., D. Z. de Back, P. J. Asif, P. J. J. H. Verkuijlen, M. Veldthuis, P. C. Ligthart, J. Berghuis, et al. "Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging." Blood Advances 2, no. 1 (January 3, 2018): 14–24. http://dx.doi.org/10.1182/bloodadvances.2017013094.
Повний текст джерелаАнотація:
Key Points The Lu/BCAM adhesion molecule is gradually activated during erythrocyte aging due to loss of sialic acid on glycophorin-C. Upon activation, Lu/BCAM engages a sialic acid–dependent interaction with the extracellular matrix protein laminin-α5.
Дисертації з теми "Bcnam"
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Thera, Korotimi. "Analyse des déterminants génétiques contrôlant la production et la composition de la tige chez le sorgho (Sorghum bicolor [L.] Moench). Intégration des approches bi-et multi-parentales." Electronic Thesis or Diss., Montpellier, SupAgro, 2017. http://www.theses.fr/2017NSAM0030.
Повний текст джерелаАнотація:
Le sorgho est une des espèces de céréales les plus importantes au niveau mondial en termes d’alimentation humaine et animale. En outre, de nouvelles voies de valorisations liées à son haut potentiel de production de biomasse émergent (énergie, biomatériaux) avec des possibilités d’applications aux niveaux des pays du Nord et du Sud. L’identification des facteurs génétiques contrôlant la variabilité de la production et de la qualité de la biomasse est un des vecteurs de développement de variétés adaptées aux différentes utilisations. Actuellement, seule une vision partielle de l’architecture génétique de la production et de la qualité de la biomasse est disponible, pénalisant l’efficacité des programmes de sélection. Les principales raisons qui peuvent être évoquées sont : l’utilisation quasi exclusive de populations à base génétique très étroite (population biparentales correspondant à des idéotypes peu divers) et un manque de compréhension des interactions existantes entre la qualité de la biomasse et la phénologie. Dans ce contexte, cette thèse s’est articulée autour de 3 objectifs : i) apporter une meilleure compréhension du déterminisme génétique de la durée du cycle « semis - floraison » et de la hauteur des plantes dans le contexte de variétés sensibles à la photopériode, lesquelles ont été relativement peu travaillées jusqu’à présent , ii) analyser les interactions entre la qualité de la biomasse, la croissance en hauteur, la durée du cycle et la sensibilité au photopériodisme et iii) affiner notre compréhension des mécanismes moléculaires impliqués dans la variation de la qualité de la biomasse. Pour mener à bien ces analyses, deux populations de cartographie biparentales, un panel de diversité correspondant aux 35 parents d’un schéma de croisement multiparental (Backcross Nested Association Mapping) ainsi que leurs descendances (29 populations totalisant environ 1200 BC1F4) ont été caractérisés en termes de croissance, de phénologie et de qualité de la biomasse. L’analyse du déterminisme génétique de la phénologie couplée à une approche de modélisation écophysiologique a permis la mise en évidence d’une région chromosomique contrôlant une large part de la variabilité de la photopériode critique. Le gène ELF3 pour lequel plusieurs évidences fonctionnelles ont été mises en évidence chez d’autres espèces, est un candidat potentiel pour expliquer cet effet. Outre une large convergence entre les zones détectées pour la phénologie au sein de cette thèse et les études précédentes, une forte instabilité des zones détectées en fonction des conditions environnementales (dates de semis, année) a été mise en évidence. L’analyse des relations entre la qualité de la biomasse, la croissance en hauteur, la précocité et la sensibilité à la photopériode a mis en évidence des effets important du nanisme et de la date de semis sur la composition des tiges et des relations entre ses composantes. En outre, des différences de réactions à la variabilité des dates des semis ont été observées en fonction de la sensibilité à la photopériode des génotypes considérés. Enfin, la caractérisation de la composition biochimique des tiges (teneur en cellulose, en hémicellulose et en lignine des parois) au sein des 29 populations BC1F4, a mis en évidence de nombreuses zones chromosomiques pour lesquelles des gènes potentiellement causatifs ont été proposés. Ces analyses ont permis d’alimenter un répertoire de régions chromosomiques contrôlant les caractères cibles de la sélection. Les potentialités de ces résultats et des populations développées (bi- et multiparentales) dans le contexte de la sélection ainsi que de la validation des gènes sous-jacents à ces zones sont discutéesSorghum ranks fifth in terms of grain production at the worldwide level. It contributes to food security in the developing countries and provides a significant share of the animal caloric intake. In addition sorghum is expected to contribute significantly to the emerging energy and biomaterial value chains. In this context, identification of the genetic factors controlling biomass production and quality is of crucial interest to develop varieties fitting the expectations of the different uses. Currently only a partial vision of the genetic architecture of biomass production and quality is available, hampering optimal breeding efficiencies. This can be explained by a limited use of the genetic diversity pool to dissect the genetic control of the traits of interest (mainly restricted to non-photoperiod sensitive varieties until now) and a limited understanding of the relationships between biomass production (largely driven by phenology variability) and quality. In this context, this PhD aimed at i) providing a better understanding of the genetic bases of flowering and height variabilities using photoperiod sensitive genetic material ii) disentangling the interactions between biomass quality, height, cycle duration and photoperiod sensitivity and iii) refining our understanding of the molecular mechanisms involved in the variation in biomass quality. To tackle these challenges, two biparental QTL mapping populations, a diversity panel including 35 parents of a Backcross Nested Association Mapping design and a subset of their progenies (29 populations encompassing a total of 1200 BC1F4) were characterized for their phenology, growth and biomass composition. The analysis of the genetic determinism of phenology coupled with an ecophysiological modeling approach, revealed a chromosomic region controlling a large part of the variability (60%) of critical photoperiod (a component of cycle duration). The gene ELF3, for which functional evidence of impact on photoperiod sensitivity is available in other species can be proposed as a functional driver of the variability induced by this region. Although a significant proportion of the genomic regions detected in this study have already been revealed in previous studies, several new regions have been discovered, underlying the interest of multiparental based designs. Phenology analyses over different sowing dates highlighted the complexity of the genetic determinism of this trait through the detection of genomic regions with variable effects. In depth analyses of biomass quality relationships with height, precocity and photoperiod sensitivity underlined strong dwarfism and sowing dates effects on the components of biomass quality and their relationships. In addition, different behaviors of photoperidiod sensitive and insensitive genotypes to delayed sowing dates have been observed. Finally, characterization of stem biochemical composition (cellulose, hemicellulose and lignin content of the cell walls) on the 29 BC1F4 populations, revealed numerous chromosomic regions with variable effects. Putative candidate genes from these regions of interest have been opposed. These analyses enriched a library of regions impacting the breeding targets linked to biomass production and quality. The potentials of these results and of the populations developed towards optimization of breeding efficiency and gene function validation have been discussed
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Bartolucci, Pablo. "Adhérence des globules rouges dans la Drépanocytose : rôle de Lu/BCAM et action de l'hydroxycarbamide." Paris 7, 2011. http://www.theses.fr/2011PA077003.
Повний текст джерелаАнотація:
Les phénomènes d'adhérence entre les globules rouges (GR) drépanocytaires et la paroi vasculaire interviennent dans la physiopathologie des accidents d'ischémie-reperfusion caractéristiques de la maladie. Parmi les molécules d'adhérence, Lu/BCAM est le seul ligand érythrocytaire de la laminine. Cependant aucune étude n'a montré son implication dans les manifestations cliniques de la drépanocytose. Enfin, l'effet de l'hydroxycarbamide (HC) sur la fonction de Lu/BCAM n'a pas été étudié. Nous avons montré que l'adhérence des GR drépanocytaires à la laminine est augmentée au cours des crises vaso-occlusives sévères et chez les patients ayant des atteintes viscérales sévères à l'état basai. Les patients traités par l'HC ont une adhérence diminuée. Il existe une augmentation paradoxale de Lu/BCAM sous HC. Cependant l'HC diminue la phosphorylation de Lu/BCAM dans les GR de façon parallèle à la diminution d'adhérence. Cette diminution de phosphorylation est liée à l'inhibition d'une voie d'activation PKA/AMPc dépendante. Nous avons confirmé cette diminution d'adhérence et de phosphorylation sous HC dans un modèle cellulaire érythroleucémique (K562). Enfin nous avons montré que la voie d'activation de Lu/BCAM par phosphorylation était presque exclusivement présente dans les réticulocytes. Ce travail montre pour la première fois que la fonction d'adhérence de Lu/BCAM à la laminine est corrélée à la gravité clinique. D'autre part il démontre l'action de l'HC sur l'inhibition de la fonction d'adhérence de Lu/BCAM, par un mécanisme distinct de l'expression de l'hémoglobine fœtale, ouvrant ainsi de nouvelles perspectives thérapeutiquesSickle cell disease is characterized by painful vaso-occlusive crises during which abnormal interactions between erythroid adhesion molecules and vesselwall proteins are thought to play a critical role. Hydroxyurea, the only drug with proven benefit in sickle cell disease, diminishes these interactions, but its mechanism of action is not fully understood. We report that, under hydroxyurea, expression of the unique erythroid laminin receptor Lu/BCAM was increased, but red blood cell adhesion to laminin decreased. Because Lu/BCAM phosphorylation is known to activate cell adhesion to laminin, it was evaluated and found to be dramatically lower in hydroxyureatreated patients. Analysis of the protein kinase A pathway showed decreased intracellular levels of the upstream effector cyclic adenosine monophosphate during hydroxyurea treatment. Using a cellular model expressing recombinant Lu/BCAM, we showed that hydroxyurea led to decreased intracellular cyclic adenosine monophosphate levels and diminished Lu/BCAM phosphorylation and cell adhesion. We provide evidence that hydroxyurea could reduce abnormal sickle red blood cell adhesion to the vascular wall by regulating the activation state of adhesion molecules independently of their expression level
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Kelle, Nicole [Verfasser], and Leticia [Akademischer Betreuer] Oliveira-Ferrer. "Einfluss von ICAM1, ICAM2 und BCAM auf die Metastasierung und die Prognose des Ovarialkarzinoms / Nicole Kelle ; Betreuer: Leticia Oliveira-Ferrer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1181328934/34.
Повний текст джерела
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Kelle, Nicole [Verfasser], and Ferrer Leticia [Akademischer Betreuer] Oliveira. "Einfluss von ICAM1, ICAM2 und BCAM auf die Metastasierung und die Prognose des Ovarialkarzinoms / Nicole Kelle ; Betreuer: Leticia Oliveira-Ferrer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://nbn-resolving.de/urn:nbn:de:gbv:18-96219.
Повний текст джерела
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Huang, Jin. "Rôle de lutheran/ Basal Cell Adhesion Molecule (Lu/BCAM) dans la permsélectivité glomérulaire et l'adhérence leucocytaire au cours des néphropaties murines." Paris 7, 2013. http://www.theses.fr/2013PA077113.
Повний текст джерелаАнотація:
La glycoprotéine Lu/BCAM, a initialement été découverte comme un antigène de groupe sanguin. Etant fortement exprimée dans l’endothélium rénal, on suggère qu'elle a un rôle majeur dans l'adhérence leucocytaire ainsi que dans le contrôle de permsélectivité glomérulaire. C'est un récepteur avec deux types moléculaire. D'une part la laminine α5 qui compose en particulier les laminines 10 et 11 de la matrice sous-endothéliale, d'autre part l'intégrine α4ß1 (VLA-4) présente à la surface leucocytaire. Les souris Lu/BCAM1' présentent de légères anomalies au niveau de la morphologie glomérulaire, telles qu'un épaississement local de la membrane basale glomérulaire (MBG) et parfois un élargissement des pieds des podocytes. Nous avons donc émis deux hypothèses : Premièrement, l'expression endothéliale de Lu/BCAM pourrait favoriser l'adhérence leucocytaire à l’endothélium via l'intégrine α4ß1 (VLA-4) ; deuxièmement, Lu/BCAM pourrait limiter la permsélectivité glomérulaire en favorisant l'ancrage des cellules endothéliales à la MBG contenant la laminine. Afin de tester notre première hypothèse, un modèle de glomérulonéphrite rapidement progressive (GNRP) a été induit par injection de sérum néphrotoxique (NTS) contenant un anticorps anti-MBG. Les souris Lu/BCAM~ NTS-traitées montrent une protection dans le contexte de protéinurfe, de la fonction rénale, de l'histologie rénale, de la formation des glomérulaires à croissant, du dépôt de fibrine, du nombre de podocyte et de l'infiltration leucocytaires (CD3, F4/80, MAC-1, MAC-3, CD68). Le test d'adhérence leucocytaire humain a confirmé que les leucocytes adhèrent sur Lu-Fc via α4ß1. Pour répondre à notre deuxième hypothèse, les souris ont été soumises au modèle d'HTA par perfusion d'angiotensine II pendant 28 jours ou par administration d'un inhibiteur de NO synthase (L-NAME) pendant 90 jours. Les deux traitements induisent une augmentation similaire de la pression artérielle chez les deux groupes de souris. Pourtant, les souris Lu/BCAM ~ présentent une augmentation plus importante de l'albuminurie avec un traitement à l'AngII et au L-NAME comparées aux souris contrôles. Une précipitation massive de l'albumine a été fréquemment observée dans la chambre urinaire chez les souris Lu/BCAM1' traitées à l'AngII. De plus, nous avons testé la permsélectivité vasculaire au niveau des carotides. La diffusion sous endothéliale de dextran (70KDa) couplé au FITC était augmentée en absence de Lu/BCAM. Enfin, les souris Lu/BCAM ~ présentent une augmentation de perméabilité au BE au niveau des reins. Cette hyperperméabilité n'est pas différente dans le cerveau, la rate ou le foie. En conclusion, nos résultats suggèrent que : 1, Lu/BCAM entraine une accumulation des leucocytes (notamment monocytes et polynucléaires neutrophiles) dans le glomérule inflammatoire. Les effets de cette Glycoprotéine sur le recrutement leucocytaire sont possibles via la liaison Lu/BCAM/VLA-4. 2, Lu/BCAM n'a pas d'effet sur la pression artérielle systolique induite par l'AnglI mais elle joue un rôle essentiel dans la perméabilité glomérulaire au cours de l'HTA et dans la perméabilité endothéliale extra-rénaleLu/BCAM blood group glycoprotein, due to its important expression in renal endothelium, is suggested involved in facilitating accumulation of leukocyte and maintained the glomerular permselectivity. Lu/BCAM has been recognized as a receptor for two types of molecules. On one hand, it is a receptor for laminin α5 chain which constitute in particular lamininlO and 11 in the sub-endothelial matrix; on the other hand, it is a receptor for integrin α4ß1 (VLA-4) which present on the surface of leukocyte. Lu/BCAM-/-mice exposes abnormalities characterized by an irregular thickening of the glomerular basement membrane and sometimes an abnormal enlargement of foot process of podocyte. We have made two hypotheses: firstly, Lu/BCAM could promote leukocyte adhesion on endothelium via integrin α4ß1; secondly, Lu/BCAM could limit glomerular permselectivity by maintaining EC to GBM containing laminin α5 chain. To respond our first hypothesis, a passive RPGN model has been used. In this model, Lu/BCAM-/-mice attenuated glomerular accumulation of T cells and macrophages, crescent formation, and proteinuria, correlating with reduced fibrin and platelet déposition in glomeruli. Furthermore, we found pro-adhesive interaction between human monocyte α4ß1 integrin and Lu/BCAM proteins. For proving our second hypothesis, hypertension and glomerulosclerosis were induced by high salt diet (5% NaCl) and chronic infusion of Angiotensin II (l μ g/kg/min) or PBS in an osmotic mini-pump for 28 days or by administration of a NO syntheses inhibitor L-NAME in Lu-/-mice for 90 day in Lu/BCAM-/- mice and their wild-type littermates. Despite of a similar arterial tension, Lu/BCAM-/- hypertensive mice exhibited higher albuminuria. During Dextran-FITC (70K Da) diffusion test, a vascular hyper-permeability was observed in Lu/BCAM-/- carotid compared with their WT group. Furthermore, Lu/BCAM-/- mice displayed also a renal hyper-permeability during evans bleu permeability test, but this hyperpermeability was not found in the other organs such as brain, spleen and liver. In conclusion, the results indicated that: 1, Lu/BCAM-/- mice could possess a nephroprotective function in the early stage of GNRP when the leukocyte (monocyte and macrophage in particular) attached to into inflammatory glomerulus. It's function of leukocyte recruitment was possibly accomplished via VLA-4 ; 2,Lu/BCAM has no effect on systolic blood pressure but it plays a major role in glomerular permselectivity during hypertension and it has a extra reral endotherial permeability
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Collec, Emmanuel. "Fonction de la molécule d'adhérence Lu/BCAM, récepteur de la chaine α5 de la laminine dans les cellules épithéliales rénales MDCK : régulation par interaction avec les protéines Ubc9 et spectrine". Paris 7, 2010. http://www.theses.fr/2010PA077059.
Повний текст джерелаАнотація:
Lu/BCAM est une molécule d'adhérence, récepteur de la laminine 511/521 dans les cellules érythroïdes, endothéliales ainsi que dans les tissus épithéliaux. Elle lie la spectrine dans les globules rouges. La lysine 585 présente dans son domaine cytoplasmique, interagit avec l'enzyme Ubc9 dans les cellules épithéliales rénales. Ubc9 forme un complexe avec Lu/BCAM endogène ou recombinant dans les cellules épithéliales A498 et MDCK respectivement. Les cellules MDCK transfectées avec un mutant de Lu/BCAM incapable de lier Ubc9, montrent une localisation membranaire basolatérale, une demi-vie membranaire augmentée et une adhérence et un étalement à la laminine renforcée. La spectrine-all forme un complexe avec Lu/BCAM endogène ou recombinant dans les cellules épithéliales A498 et MDCK, respectivement. Le mutants mt-Lu indique que l'absence d'interaction avec la spectrine conduit à un affaiblissement de l'interaction avec le squelette dépendant de la spectrine, comme le montre l'augmentation de son extractabilité au Triton X-100. Les cellules MDCK transfectées avec mt-Lu, incapable de lier la spectrine, montrent une localisation membranaire basolatérale, une demi-vie à la membrane augmentée et une, adhérence "et un étalement significativement renforcée à la laminine qui n'est pas corrélée à l'état de phosphorylation de Lu/BCAM. Nous montrons pour la première fois, que cette interaction est impliquée dans une signalisation allant de la laminine à Tactine conduisant à la formation de fibres de stress dans les cellules cultivées sur laminine. Ce signal est associé à l'activation de la petite GTPase RhoA qui est dépendante de l'intégrité du motif d'interaction de Lu/BCAM la laminineLu/BCAM is an adhésion molecule, receptor of laminin 511/521 in erythroïd cells as well as in epithelial tissues and endothelial cells. Lu/BCAM binds also directly to al spectrin in red blood cells. The lysine 585 present in its cytoplasmic domain interacts directly with the enzyme Ubc9 in renal epithelial MDCK cells. Ubc9 forms a complex with endogenous or recombinant Lu/BCAM in epithelial MDCK and A498 cells respectively. MDCK cells transfected with a mutant of Lu/BCAM, unable to bind Ubc9, showed a basolateral membrane localization, greater extended half-life at the membrane and enhanced adhesion and spreading on laminin. The all-spectrin forms a complex with endogenous or recombinant Lu/BCAM in epithelial MDCK and A498 cells respectively. The mutant mt-Lu indicates that the lack of interaction with all-spectrin leads to a weakening of the interaction with the cell membrane cytoskeleton of non-erythroïd cells, as shown by the increase in its extractability with Triton X-100. MDCK cells transfected with a Lu/BCAM mutant unable to bind spectrin (mt-Lu) exhibited a normal basolateral expression but enhanced half-life at the membrane. In addition, adhesion and spreading of epithelial MDCK cells on laminin were significantly reinforced in the mt-Lu and this is not related to the phosphorylation status of Lu/BCAM. We show for the first time that this interaction is involved in signaling from laminin to actin leading to the formation of stress fîbers in cells growning on laminin. This rearrangement of the actin skeleton is associated with an activation of the small GTP specifîcally -binding protein RhoA that is dependant to the laminin binding site integrity of the Lu/BCAM
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Lizarralde, Iragorri Maria. "Impact of mechanical and oxidative stress on red blood cell properties in sickle cell disease." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC324.
Повний текст джерелаАнотація:
Le globule rouge est une cellule simple avec l’une des fonctions les plus importantes de l’organisme : participer aux échanges gazeux et fournir l’oxygène aux tissus. C'est un disque biconcave hautement élastique grâce à un réseau de protéines du cytosquelette et de protéines membranaires spécifiques. La fonction, ainsi que la structure des globules rouges sont altérées dans plusieurs pathologies humaines telles que les hémoglobinopathies et les anomalies de membrane. La drépanocytose est une maladie héréditaire génétique caractérisée par une hémoglobine anormale qui polymérise en conditions hypoxiques provoquant la déformation des globules rouges circulants. La drépanocytose se caractérise également par une anémie hémolytique chronique et des crises vaso-occlusives douloureuses dues à l'obstruction des capillaires.Dans le but de mieux comprendre les mécanismes responsables des manifestations cliniques, nous avons étudié les propriétés mécaniques et adhésives des globules rouges de patients atteints de drépanocytose en évaluant 1) l'impact de contraintes mécaniques répétées sur la survie des globules rouges à l'aide d'un appareil microfluidique qui mime la microcirculation et 2) le rôle du stress oxydant dans l'activation des protéines d'adhérence érythroïde.Nous avons conçu une puce microfluidique et montré que le stress mécanique est un paramètre critique sous-jacent à l'hémolyse intravasculaire dans la drépanocytose et que des taux intracellulaires élevés d'hémoglobine fœtale préviennent cette lyse. Outre ces résultats, nous avons constaté que le traitement à l'hydroxyurée protège les globules rouges de la lyse lors d'un stress mécanique, même en l'absence d'expression de l'hémoglobine fœtale. D'autre part, nous avons étudié la structure et la fonction de la protéine d'adhérence érythroïde Lu/BCAM dans des conditions oxydantes en utilisant des approches biochimiques et d'imagerie. Nous avons observé que le stress oxydant active la fonction adhésive de Lu/BCAM par des modifications post-traductionnelles qui modifient sa distribution membranaire. Nous décrivons un nouveau mécanisme qui affecte les interactions en cis de Lu/BCAM à la surface cellulaire et qui pourraient expliquer l'adhérence anormale des globules rouges à la laminine en l'absence d'événements de phosphorylation.En conclusion, nous avons développé un modèle microfluidique reproduisant les dimensions physiologiques des microvaisseaux humains, permettant d’évaluer les caractéristiques cellulaires jusque-là inexplorées dans la drépanocytose. Nous montrons que le stress mécanique répété est en partie responsable de l'hémolyse chez les patients atteints d'anémie falciforme, ce qui pourrait contribuer aux niveaux élevés de stress oxydant en raison de l'hème libre dans la circulation. Nos travaux démontrent l'importance de la dimension mécanique dans l’obstruction des capillaires et la contribution critique du stress oxydant dans l'adhérence anormale des globules rouges dans cette maladie. Améliorer la déformabilité des globules rouges et cibler le stress oxydant pour inhiber l'adhérence des globules rouges serait une stratégie prometteuse pour cibler les principales caractéristiques de cette pathologie et alléger le fardeau de la maladieThe red blood cell is a simple cell with one of the most important functions in the organism, that is fulfilling the gas exchange function and delivering oxygen to the tissues. It is a highly elastic biconcave disk thanks to a network of specific skeletal and membrane proteins. The function and structure of the red cell are altered in several human pathologies like hemoglobinopathies and membrane disorders. Sickle cell disease is a genetic hereditary disorder characterized by abnormal hemoglobin that polymerizes under hypoxic conditions leading to the sickling and alteration of circulating red cells. The hallmarks of sickle cell disease are hemolytic anemia and painful vaso-occlusive crises due to the obstruction of fine capillaries.With the aim of better understanding the mechanisms behind these clinical manifestations we investigated the mechanical and adhesive properties of red blood cells from patients with sickle cell disease by assessing 1) the impact of repeated mechanical stress on red cell survival using a microfluidic device that mimic human microcirculation, and 2) the role of oxidative stress in the activation of erythroid adhesion proteins.We designed a microfluidic device that allowed us to show that mechanical stress is a critical parameter underlying intravascular hemolysis in sickle cell disease and that high intracellular levels of fetal hemoglobin protect against lysis. Furthermore, we found that treatment with hydroxyurea protects red blood cells from lysis upon mechanical stress even in the absence of fetal hemoglobin expression. On the other hand, we investigated the structure and function of the erythroid adhesion protein Lu/BCAM under oxidative conditions using biochemical and imaging approaches. We observed that oxidative stress activates the adhesive function of Lu/BCAM through post-translational modifications that alter its membrane distribution. We describe a novel mechanism that affects Lu/BCAM cis-interactions at the cell surface that might account for the abnormal adhesion of sickle red cells to laminin in the absence of phosphorylation events.In conclusion, we developed a microfluidic device replicating the physiological dimensions of human microvessels that allows assessing previously unexplored cellular characteristics in sickle cell disease. We show that repeated mechanical stress is partly responsible for hemolysis in patients with sickle cell disease, which might contribute to the high levels of oxidative stress because of free heme in the circulation. Our work demonstrates the importance of the mechanical dimension in the blockade of small capillaries and the critical contribution of oxidative stress in the abnormal adhesion of red cells in this disease. Improving red cell deformability and targeting oxidative stress to inhibit red cell adhesion would be promising strategies to target the main hallmarks of this pathology and alleviate the disease burden
Частини книг з теми "Bcnam"
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Christensen, Georg K., and Ole Bech Mogensen. "Backward form feature recognition and removal for an automatic CNC-programming system — BCAM." In Advanced CAD/CAM Systems, 205–16. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-0-387-34834-6_12.
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De Clercq, Erik. "Highly Potent and Selective Inhibition of Varicella–Zoster Virus Replication by Bicyclic Furo[2,3-d ]pyrimidine Nucleoside Analogues (BCNAs)." In Monographs in Virology, 131–42. Basel: KARGER, 2006. http://dx.doi.org/10.1159/000096267.
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Li, Ali, Rui Wang, Liyuan Liu, Lei Xu, Fei Wang, Fei Chang, Lixiang Yu, Yujuan Xiang, Fei Zhou, and Zhigang Yu. "BCRAM: A Social-Network-Inspired Breast Cancer Risk Assessment Model." In Cyber-Enabled Intelligence, 171–93. Taylor & Francis, 2019. http://dx.doi.org/10.1201/9780429196621-9.
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Tang, Valerie, and H. Y. Lam. "Integration of BIoT and Artificial Intelligence for Long-Term Geriatric Care Management." In Revolutionizing Digital Healthcare Through Blockchain Technology Applications, 163–86. IGI Global, 2023. http://dx.doi.org/10.4018/978-1-6684-6509-7.ch008.
Повний текст джерелаАнотація:
The aging problem has become a global issue, which is driving an increasing demand for long-term care services for the elderly. Care planning, as an essential support to ensure a high standard of safe and responsive care, is therefore drawing attention from academia and health care providers. To handle the increasing care service demand and enhance the care service quality, a support model in care planning is needed to handle episodic visits, to integrate the care plan with all of the relevant data, and to allow all stakeholders to view and contribute to. In this study, the above described supporting model is formulated through a blockchain-internet of things (BIoT) based care planning analytics model (BCPAM). Embedding blockchain into IoT allows collecting patient's data in real time and decentralizing such data in the nursing home network to achieve effective care planning. In addition, such information is further utilized for healthcare analysis to predict the long-term needs of the elderly.
Тези доповідей конференцій з теми "Bcnam"
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Maciaszek, J. L., B. Andemariam, and G. Lykotrafitis. "Red Blood Cell Surface Receptor Expression of BCAM/Lu is Regulated by Protein Kinase A Activity." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14311.
Повний текст джерелаАнотація:
Irregular sickle red blood cells (RBCs) can contribute to the pathogenesis of vasoocclusion and other complications of sickle cell disease (SCD) via abnormal adherence to the vascular endothelium. It has previously been demonstrated that epinephrine enhances SCD RBC adhesion by activating the BCAM/Lu and ICAM-4 surface receptors [1–2]. Epinephrine acts on the RBC β2-adrenergic receptor, thereby activating Gas proteins that stimulate adenylyl cyclase (AC). This enzyme catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP), leading to protein kinase A (PKA) activation, an intermediate step in the upregulation of BCAM/Lu and ICAM-4 mediated adhesion. The interaction of BCAM/Lu with the α5 chain of laminin may contribute to vaso-occlusive events in SCD due to overexpression of BCAM on SCD RBCs.
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Maciaszek, Jamie L., Biree Andemariam, and George Lykotrafitis. "Modulation of BCAM/Lu and ICAM-4 Expression on Red Blood Cell Membranes in Physiological Stress Conditions." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-62143.
Повний текст джерелаАнотація:
Using single-molecule atomic force microscopy (AFM) experiments, we report that epinephrine, a hormone secreted during stress and strenuous exercise, increases both the frequency and strength of adhesion events of sickle cell trait erythrocytes to the endothelial extracellular matrix (ECM). The specific interactions quantified include Lutheran (BCAM/Lu) and intercellular adhesion molecule-4 (ICAM-4) on the RBC surface with ECM laminin and endothelial αvβ3, respectively. These data present significant evidence of the role of epinephrine in BCAM/Lu-laminin and ICAM-4-αvβ3 bonding, and suggest mechanisms of vaso-occlusion during physical exertion in SCT.
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Jeloka, Supreet, Naveen Akesh, Dennis Sylvester, and David Blaauw. "A configurable TCAM/BCAM/SRAM using 28nm push-rule 6T bit cell." In 2015 Symposium on VLSI Circuits. IEEE, 2015. http://dx.doi.org/10.1109/vlsic.2015.7231285.
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Koo, Jongeun, Eunhwan Kim, Seunghyun Yoo, Taesu Kim, Sungju Ryu, and Jae-Joon Kim. "Configurable BCAM/TCAM Based on 6T SRAM Bit Cell and Enhanced Match Line Clamping." In 2019 IEEE Asian Solid-State Circuits Conference (A-SSCC). IEEE, 2019. http://dx.doi.org/10.1109/a-sscc47793.2019.9056974.
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Cheng, Wei-Yi, Tai-Hsien Ou Yang, Matthew Maurer, and Dimitris Anastassiou. "Abstract 2878: BCAM (breast cancer attractor metagenes): A new tool for assessing breast cancer prognosis." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2878.
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Khazem, Hala, Dvir Reder, Shilhav Meisel Sharon, Shay Hantisteanu, Hallak Mordechai, Haim Werner, and Ilan Bruchim. "EP209/#686 BCAM-AKT2 fusion protein and the IGF1 signaling pathway in epithelial ovarian cancer." In IGCS 2022 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-igcs.300.
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Manikandan, Palanichamy, Bjørn B. Larsen, and Einar J. Aas. "Design of novel CAM core cell structures for an efficient implementation of low power BCAM system." In the 19th ACM Great Lakes symposium. New York, New York, USA: ACM Press, 2009. http://dx.doi.org/10.1145/1531542.1531559.
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Yen, Laising. "Abstract IS02: BCAM-AKT2 FUSION GENE LEADS TO A CONSTITUTIVELY ACTIVATED AKT2 FUSION KINASE IN HGSC." In Abstracts: 11th Biennial Ovarian Cancer Research Symposium; September 12-13, 2016; Seattle, WA. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3265.ovcasymp16-is02.
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Nguyen, NM, IV Krits, DK Kobayashi, CL Moulson, and JH Miner. "Lutheran/Bcam Null Mice Have an Attenuated Response to Bleomycin with Reduced Expression of CCL12 (MCP-5)." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a3439.
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Khazem, Hala, Shilhav meisel Sharon, Shay Hantisteanu, Mordechai Hallak, Haim Werner, and Ilan Bruchim. "#348 The BCAM-AKT2 fusion protein effect on the IGF1 signaling pathway in epithelial ovarian cancer cells." In ESGO 2023 Congress. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/ijgc-2023-esgo.562.
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