Дисертації з теми "BBN modelling"
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Anderson, Jerone S. "A Study of Nutrient Dynamics in Old Woman Creek Using Artificial Neural Networks and Bayesian Belief Networks." Ohio University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1242921000.
Повний текст джерелаParkes, David [Verfasser], Ben [Akademischer Betreuer] Marzeion, Ben [Gutachter] Marzeion, and Olaf [Gutachter] Eisen. "Statistical glacier distribution in global- and regional-scale glacier modelling / David Parkes ; Gutachter: Ben Marzeion, Olaf Eisen ; Betreuer: Ben Marzeion." Bremen : Staats- und Universitätsbibliothek Bremen, 2018. http://d-nb.info/1189808145/34.
Повний текст джерелаHebeler, Felix. "Modelling topographic uncertainty : impacts on large scale : environmental modelling /." Zürich, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253809.
Повний текст джерелаBall, Kathryn. "Physiologically based pharmacokinetic modelling of the central nervous system : strategies for drug development." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P630.
Повний текст джерелаA critical step during drug development is the measurement or the prediction of drug concentrations in the target tissue, which can then be linked to measures of drug efficacy or toxicity. Drug concentrations cannot be directly measured in the human brain, and must be simulated or predicted using alternative modeling approaches. The objective of this thesis is to develop in silico approaches to predict BBB penetration of drugs, combining in vitro and in vivo preclinical data in a physiologically structured model, with a translational strategy to allow the simulation of total and free drug concentrations in the human brain. Physiologically based pharmacokinetic (PBPK) models were developed and evaluated for reference molecules already on the market, as well as for a drug currently under clinical development within the pharmaceutical industry. These models were developed based on both ‘bottom-up’ (model parameter values predicted from in vitro data) and ‘top-down’ (model parameters estimated from in vivo data) strategies. This thesis is comprised of 5 scientific papers which are either published or submitted to peer-reviewed journals. The first article is a review of the literature, published in the AAPS journal. This review discusses the currently published PBPK models available for the mechanistic prediction of BBB penetration of drugs, and proposes a strategy for in vitro-in vivo (IVIVE) extrapolation. The second article is an original research article published in Molecular Pharmaceutics. This article aims to show the development of a coherent pharmacokinetic modeling approach in the rat which can be adapted based on the quantity and quality of data obtained in vivo during the development of new drugs. A decision tree was constructed to enable the appropriate parameterization and model structure based on the available data. The third article is an original research article published in Journal of Pharmaceutical Sciences. This article was based on the development of a PBPK model for the mechanistic prediction of BBB penetration of drugs, in which the active and passive components of permeability were considered separately, as well as the intra-brain tissue binding parameters. An in vitro-in vivo strategy was proposed to extrapolate the active transport component using a relative activity factor (RAF) to account for in vitro-in vivo differences in transporter activity and/or abundance. Two additional articles are either submitted or under preparation. These articles extend the PBPK approaches described in the previous two published original research articles. The final part of this thesis consists of a discussion which emphasizes clearly the importance of the appropriate choice of modeling approach, or even better, a combination of approaches based on physiological knowledge, experimental data and knowledge gathered during the course of drug development. The advantage of mechanistic parameterization of PBPK models is the improved ability for inter-species extrapolation for the subsequent simulation of free or total drug concentrations within the human brain. This thesis has considerably contributed to this rapidly evolving field of CNS drug research and development, showing the importance of combining in vitro and in vivo data within a physiologically based model structure, thus providing a valuable tool for the quantitative prediction of the penetration of drugs in the human brain
Visen, Neeraj Singh. "Numerical modelling of the effects of bin inserts on stress distribution in storage bins for cohesive powder material." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0028/MQ32972.pdf.
Повний текст джерелаMünch, Manfred. "Generic modelling with graph rewriting systems paramateric polymorphism and object-oriented modelling with Progress /." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=970711239.
Повний текст джерелаAbdi, Tadesse. "Towards material modelling within continuum-atomistics." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=979984173.
Повний текст джерелаAugustine, Robin. "Electromagnetic modelling of human tissues and its application on the interaction between antenna and human body in the BAN context." Phd thesis, Université Paris-Est, 2009. http://tel.archives-ouvertes.fr/tel-00499255.
Повний текст джерелаAussavy, Delphine. "Processing characterization and modeling of thermomechanical properties of threee abradable coatings : NiCrAl-bentonite, CoNiCrAlY-BN-polyester, and YSZ-polyester." Thesis, Belfort-Montbéliard, 2016. http://www.theses.fr/2016BELF0311/document.
Повний текст джерелаThe objective of this work was to estimate apparent thermomechanical properties of abradable coating. Abradablematerials are strongly heterogeneous structures and the aim was to consider their detailed microstructure. Theinterest of this work is to overstep one difficulty when manufacturing abradable coating which is their dimensioning.Three abradable coatings having different nature and different microstructures have been studied. Theirmicrostructure complexity was different one from each other. Their properties were determined by a 2D modelingmethod which was applied directly pixel by pixel to take account of all the microstructural details. To validate themodeling method, the results calculated were coupled and compared to experimental ones. Two modeling methodhave been applied, a conventional one, with coating image representing coating microstructural details as well asthe global coating microstructural distribution and a 2-scale modeling method, with one scale representing themicrostructural details of the matrix and a second on representing the global coating coarse pores distribution. Onemain conclusion of this work is the following one: If the material complexity increases, the number of scalemandatory to describe the real microstructure increases. The 2-scales modeling method has been validated throughcomparison of the calculated values with those obtained experimentally. This work helps to provide a tool for digitallyselect the most promising abradable layers with the effect of reducing the number of experimental tests, which arelonger and more expensive to implement. It is a tool for decision support in the abradable coating development
Bräuer, Lars. "Modelling- und Mutationsstudien an ausgewählten prenylierenden Enzymen." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=984732004.
Повний текст джерелаDehn, Matthias. "Self-consistent dust modelling in brown dwarfs." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=983790078.
Повний текст джерелаBlumenau, Alexander Thorsten. "The modelling of dislocations in semiconductor crystals." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967384788.
Повний текст джерелаScheubert, Peter. "Modelling and diagnostics of low pressure plasma discharges." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966327535.
Повний текст джерелаVan, Loon Jasper. "Functional and stochastic modelling of satellite gravity data /." Delft : NCG Nederlandse Commissie voor Geodesie, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?u20=9789061323075.
Повний текст джерелаMenche, Gerd. "Molecular modelling Untersuchungen zur Enantiomerentrennung in der HPLC." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=97430476X.
Повний текст джерелаSchulze, Carsten. "Modelling and evaluating the aquatic fate of detergents." Doctoral thesis, [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=961702001.
Повний текст джерелаRöhrig, Manfred. "Modelling the light competition between crops and weeds." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=956719619.
Повний текст джерелаEtzmuss, Olaf. "Animation of surfaces with applications to cloth modelling." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964263211.
Повний текст джерелаRexfort, Claudia. "A contribution to fire detection modelling and simulation." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971472572.
Повний текст джерелаNa, Yong-Su. "Modelling of current profile control in tokamak plasmas." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=970018460.
Повний текст джерелаMaier, Uli. "Modelling of natural attenuation in soil and groundwater." Tübingen : Universität Tübingen, 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11759436.
Повний текст джерелаVinueza-Peter, Lorena. "Empirical modelling of environmental risks." Berlin Logos-Verl, 2004. http://deposit.ddb.de/cgi-bin/dokserv?id=2619713&prov=M&dok_var=1&dok_ext=htm.
Повний текст джерелаMenzel, Andreas. "Modelling and computation of geometrically nonlinear anisotropic inelasticity." Kaiserlautern : Univ., Lehrstuhl für Techn. Mechanik, 2002. http://deposit.d-nb.de/cgi-bin/dokserv?idn=967985978.
Повний текст джерелаNigh, Gordon Donald. "A process oriented approach to modelling forest tree mortality /." Toronto, 1994. http://opac.nebis.ch/cgi-bin/showAbstract.pl?u20=0315927828.
Повний текст джерелаÓrfão, Sandra Maria da Cunha. "Mathematical approaches to modelling and controlling blood thrombin formation." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=984084673.
Повний текст джерелаHoffmann, Thomas. "Modelling the holocene sediment budget of the Rhine system." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=984664793.
Повний текст джерелаWelzel, Udo Siegfried. "Diffraction analysis of residual stress modelling elastic grain interaction /." Stuttgart : Univ, 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10221702.
Повний текст джерелаLudwig, Alexander. "The Macroeconomics of Demographic Change - Essays on Economic Modelling." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11947808.
Повний текст джерелаWiese, Bernd Ulrich. "Spatially and temporally scaled inverse hydraulic modelling, multi tracer transport modelling and interaction with geochemical processes at a highly transient bank filtration site." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=983980969.
Повний текст джерелаBouzoubaa, Yahya. "Méthodes exactes et heuristiques pour l’optimisation de l’agencement d’un logement : application aux situations de handicap." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0369/document.
Повний текст джерелаAt an application level, this thesis deals with the layout of an accommodation intended for a disabled person. Determining the layout means choosing the position, shape and dimensions of rooms, doors and corridors. It is usually an architect's job but the complexity is such that it is very unlikely that he succeeds in optimally fulfilling all the constraints: first, there are architectural constraints: no room overlapping, sufficient width for the corridors, accessibility to and from any point, mandatory positioning of some rooms on some areas (e.g. water supply and outlet) … Then, there are constraints imposed by disabilities: enlarged corridors (wheelchairs), mandatory daily amount of efforts (fight against aging), reducing the number of steps (severe asthma), moving a room away from shared walls (deafness)... Finally, there are the wishes expressed by the future occupant, such as minimizing some journeys, maximizing the distance between two rooms or fixing a room's orientation. From a formal point of view, our work has consisted, firstly, in developing mathematical models and algorithmic methods to deal with all these constraints and, secondly, in realizing software prototypes applying these concepts. The tools we propose aim either at optimizing a layout previously designed by an architect or at synthesising a layout without any initial suggestions from the architect. Synthesis has been tackled as bin-packing-type problem (known to be NP-hard) but with additional constraints: the objects to be placed (the rooms) have variable sizes and they are submitted to functional constraints. The resolution is based on a first, initially quadratic and then linearized, mixed integer mathematical model. It has been successfully applied to position and dimension the rooms of an accommodation, to determine corridors allowing a full accessibility to all the rooms and to take into account a number of constraints coming from the disabilities of the future occupant. A second mathematical model has been formulated for the positioning of the doors and, finally, a heuristic method has been designed to assign the space used by useless corridors to adjacent rooms. The whole process has been embedded in a fully operational software. The second set of contributions is about the optimization of an existing layout. This task has been tackled through an iterative process, looping on evaluation and modification (improvement) of an accommodation. It has been implemented in four different ways: a metaheuristic (simulated annealing) and three local-search-type methods, which traverse the solution space by using specific definitions of the neighbourhood. This approach has firstly underlined the multicriteria feature of our problem and, secondly, has required the development of many computational geometry algorithms. All this work is integrated in another functional prototype software. To understand the expectations of the scientific, social and professional worlds, this project has implied to take part to various manifestations which were national or regional, in the computer science domain or in others, scientific or non-scientific, organised by various political or non-political organisations working in the field of disabilities and accessibility. This phase has resulted in many reports which have directly fed into the bibliography of this thesis
Grandpré, Jean de. "Climate modelling of the ozone layer processes and interactions /." access full-text online access from Digital Dissertation Consortium, 2006. http://libweb.cityu.edu.hk/cgi-bin/er/db/ddcdiss.pl?NR19832.
Повний текст джерелаLange, Bernhard. "Modelling the marine boundary layer for offshore wind power utilisation." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966278410.
Повний текст джерелаWendelstorf, Jens. "Ab initio modelling of thermal plasma gas discharges (electric arcs)." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961148527.
Повний текст джерелаGhosh, Robin. "Molecular-Modelling-Untersuchungen am Dopamin-D3-Rezeptor und seinen Liganden." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965629872.
Повний текст джерелаJonsson, Anna-Carin, and Anette Westh. "Distriktssköterskors och sjuksköterskors erfarenheter av att arbeta med behandlingen av patienter med ben- och fotsår i primärvården." Thesis, Högskolan i Gävle, Avdelningen för hälso- och vårdvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-27968.
Повний текст джерелаVisser, Saskia M. "Modelling nutrient erosion by wind and water in northern Burkina Faso /." Wageningen : Wageningen University and Research Centre, 2004. http://www.mannlib.cornell.edu/cgi-bin/toc.cgi?5046904.
Повний текст джерелаKanishchev, Konstantin. "Studies of the Higgs sector in H->ZZ->2l2q and bbH->4b semileptonic channels at CMS." Doctoral thesis, Università degli studi di Trento, 2013. https://hdl.handle.net/11572/368540.
Повний текст джерелаZagonjolli, Migena. "Dam break modelling, risk assessment and uncertainty analysis for flood mitigation /." London : Taylor & Francis, 2007. http://opac.nebis.ch/cgi-bin/showAbstract.pl?u20=9780415455947.
Повний текст джерелаKage, Henning. "Simulation modelling for improving nitrogen use efficiency in intensive cropping systems." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=977957020.
Повний текст джерелаHäfele, Martin. "Modelling and analysis of a production plant for low density polyethylene." [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=983643849.
Повний текст джерелаBuchwald-Werner, Sybille. "Theoretische Untersuchung zur Enantiomerentrennung an carbamoylierten Chininderivaten eine Molecular-Modelling-Studie /." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962886106.
Повний текст джерелаRiederer, Peter. "Thermal room modelling adapted to the test of HVAC control systems." Doctoral thesis, [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=967121663.
Повний текст джерелаSchwarte, Judith. "Modelling the earth's magnetic field of magnetospheric origin from CHAMP data." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971057001.
Повний текст джерелаLuttmann, Edgar. "Molecular-modelling-Untersuchungen auf dem Weg zum Verständnis der Alzheimer'schen Krankheit." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972386688.
Повний текст джерелаVollbrecht, Andrea. "Molecular-modelling-Untersuchungen an der Dihydropyridin-Bindungsstelle von offenen Ca2+-Kanälen." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972716904.
Повний текст джерелаWrede, Britta. "Modelling the effects of speech rate variation for automatic speech recognition." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=969765304.
Повний текст джерелаPeter, Anita. "Assessing natural attenuation at field scale by stochastic reactive transport modelling." Tübingen : Universität Tübingen, 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10236383.
Повний текст джерелаGuimarães, João Henrique Diniz. "Modelling the dynamic interactions of rolling bearings /." Berlin : Logos, 2008. http://deposit.d-nb.de/cgi-bin/dokserv?id=3160007&prov=M&dok%5Fvar=1&dok%5Fext=htm.
Повний текст джерелаKanishchev, Konstantin. "Studies of the Higgs sector in H->ZZ->2l2q and bbH->4b semileptonic channels at CMS." Doctoral thesis, University of Trento, 2013. http://eprints-phd.biblio.unitn.it/1280/1/Kanishchev_Thesis.pdf.
Повний текст джерелаJohnson, Sandra. "Integrated Bayesian network frameworks for modelling complex ecological issues." Thesis, Queensland University of Technology, 2009. https://eprints.qut.edu.au/32002/1/Sandra_Johnson_Thesis.pdf.
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