Дисертації з теми "Basi nervose"
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Ng, Tat-fong. "Molecular basis for regeneration of CNS : a possible regulatory role of growth associated protein-43 /." Hong Kong : University of Hong Kong, 1995. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17538786.
Повний текст джерела吳達方 and Tat-fong Ng. "Molecular basis for regeneration of CNS: a possible regulatory role of growth associated protein-43." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31235219.
Повний текст джерелаRoshan, Payam. "Cellular basis of inflammation in the enteric nervous system." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26759.
Повний текст джерелаJaramillo, Martinez Diana. "Epidemiology and pathogenesis of Nervous Necrosis Virus." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13088.
Повний текст джерелаCaruso, Giuseppe. "Basi Molecolari dei DCP (disoridni conformazionali proteici) a carico del sistema nervoso: condizioni microambientali e interrelazioni cellulari." Doctoral thesis, Università di Catania, 2014. http://hdl.handle.net/10761/1532.
Повний текст джерелаCARUSO, GIUSEPPE. "Basi Molecolari dei DCP (disoridni conformazionali proteici) a carico del sistema nervoso: condizioni microambientali e interrelazioni cellulari." Doctoral thesis, Università degli studi di Catania, 2014. http://hdl.handle.net/20.500.11769/490585.
Повний текст джерелаThe biological function of a protein depends on its tridimensional structure, which is determined by its amino acid sequence during the process of protein folding. Protein folding in the cell is a tightly regulated process, involving a series of proteins, from molecular chaperones to proteases that assist the folding process and monitor the quality of the final product. Several diseases have been shown to arise from protein misfolding and are grouped together under the name of protein conformational disorders (PCDs). The hallmark event in PCDs is a change in the secondary and/or tertiary structure of a normal protein without alteration of the primary structure. The conformational change may promote the disease by either gain of a toxic activity or by the lack of biological function of the natively folded protein. The PCDs includes Alzheimer's disease (AD), Huntington disease (HD), cystic fibrosis, diabetes mellitus type II (T2DM), Parkinson disease (PD), and many other diseases. In most of PCDs the misfolded protein is rich in beta-sheet conformation. Both T2DM and AD are characterized by insoluble protein aggregates with a fibrillar conformation. Amylin aggregation is associated with pancreatic beta-cell loss, whereas Abeta and tangle formation is associated with neuronal cell loss. For the two amyloidogenic molecules Amylin and Abeta, shared and separate modes of toxicity have been revealed, that are in part receptor-mediated, with the receptors, at least to some degree, being shared between the two molecules. Microenvironmental factors such as metal ions are known to interact with these amyloidogenic molecules, and make them toxic for cultured cells. In the present study, we show that amyloidogenic peptides spontaneously form amorphous or fibrillary aggregates. In presence of copper Abeta25 35 fibrillogenesis undergoes changes, tightly linked to the time of incubation, especially in the shift from one species to another. These changes may be related to the toxicity degree measured after treatment of neuroblastoma cell cultures (SH-SY5Y). Cellular toxicity increase, induced by incubation with copper, may be explained with a slowdown in the evolution toward not toxic structures, and a consequent stabilization of oligomeric aggregates, notoriously much more toxic than fibrillary species. The incubation favors the formation of beta-sheet structures by hA17-29. The state of aggregation changes as a function of incubation time. The presence of copper in solution slows the fibrillogenesis process, and favors the stabilization of oligomeric species, instead other factors such as zinc and ribose favor the formation of large aggregates. The neuroblastoma cells viability decreases in relation to incubation time of the peptide fragment. The pre-incubation in the presence of copper further increases the toxicity of the peptide. This decrease of viability could also depend on the formation of toxic free radical species produced as a result of Fenton reactions. The analysis of the conditioned medium from endothelial cells shown a connection between alphaB-cristallin production and cellular stress. The production of alphaB-crystallin has been shown directly proportional to the concentration of Abeta25-35 peptide used to treat cell cultures. This is in agreement with literature data in which increased production of HSP, necessary for the proper folding of proteins and for the cell protection, is connected to events of cellular stress.
Lloyd, Edward John, and mikewood@deakin edu au. "A common structural basis for central nervous system drug design." Deakin University. School of Biological Sciences, 1986. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050902.115505.
Повний текст джерелаShi, Huilin. "The common basis of sympathetic nervous system and neuroblastoma development." Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1244058100.
Повний текст джерела"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences (Cancer Biology)." Title at OhioLINK ETD site: Investigation of common bases of sympathetic nervous system and neuroblastoma development. Title from title page of PDF document. Includes bibliographical references (p. 72-75, 119-125, 152-192).
Nazer, Manoel Brandes. "Sistematização das artérias da base do encéfalo de avestruz (struthio camelus)." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/16335.
Повний текст джерелаThe ostrich (Struthio camelus) is a bird from the Struthionidae family, originated from Africa. Although the irrigation of the base of the brain of other birds has already been the source of study by some researchers, the pattern, variations, distribution and the behavior of the arteries that promote the blood irrigation in the base of ostrich's brain are not known. In this work, 30 specimens, in which the arterial system was filled with red colored latex in the common carotid arteries left and right. We systematized the arteries of the ventral face of the brain, to the right and to the left, with their respective occurrence percentage. The carotid artery (a.) of the brain, a thick caliber vase, was predominant in the right (43.3%), left (36.7%) and equivalents (20%). The intercarotid anastomosis presented a medium caliber (46.7%), thick (43.3%) and thin (10%), with flux inclination to the left (53.3%) and right (46.7%). The inner right ophthalmic a. presented, to the right, medium caliber (43.3%), thin (33.3%) and thick (23.3%); to the left, medium caliber (60%), thin (26.7%) and thick (13.3%). The caudal branch of the carotid a. of the brain was, to the right, developed (53.3%) and vestigial (33.3%). The midbrain ventral tectal a. was the collateral branch of the caudal branch of the carotid a. of the brain to the right (53.3%) and to the left (66.7%), right branch of the carotid a. of the brain to the right (43.3%) and to the left (30%) and, right branch of the basilar a. (3.3%) in both antimeres. The basilar a. was an unpaired vase (80%), double in almost the entire caliber extension (13.3%) and, presented the "island" formation in its segment of thick caliber (6.7%). The caudal ventral cerebellar a. was single (96.7%) and double (3.3% to the right and, single (93.3%) and double (6.7%) to the left. The dorsal spinal a. was a collateral branch of the caudal ventral cerebellar a. to the right (96.7%) and to the left (93.3%), which was also a branch of the thin portion of the basilar a. to the right (3.3%) and to the left (6.7%). The ventral spinal a., always a branch of the basilar a., was double (90%) and single (10%). The rostral branch of the carotid a. of the brain, a vase of thick caliber, presented, to the right, a standard path (86.7%) and a rostral displacement (13.3%) and, to the left, a standard path (83.3%) and a rostral displacement (16.7%). The caudal brain a., to the right, was double (90%) and single (10%); to the left, it was double (53.3%) and single (46.7%). The medium cerebral a., in both antimeres, was a single vase (100%) and of thick caliber, being that the second collateral branch of the rostal branch of the brain carotid a. The brain ethmoidal a. foi single (100%), of medium to thick caliber, in both antimeres. The rostral brain a. was single (90%) and double (10%) to the right and single (96.7%) and double (3.3%) to the left. The ethmoidal a. was single (100%), of medium to thick caliber, being the natural continuity of the brain ethmoidal, after the emission of the rostral brain a.. The brain artery circle was rostrally open (100%) and, caudally, open (80%) and closed (20%).
Hayden, James Timothy. "The molecular basis for central nervous system primitive neuroectodermal tumour development." Thesis, University of Newcastle upon Tyne, 2012. http://hdl.handle.net/10443/1598.
Повний текст джерелаEichhorn, Klaus-Gregor. "Entwicklung eines Fragebogens zur Diagnostik von Essstörungen auf Basis von Daten etablierter diagnostischer Verfahren." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-192711.
Повний текст джерелаSilva, Carlos Eduardo da. "Uso de fluoresceína sódica em meningeomas da base do crânio." Pontifícia Universidade Católica do Rio Grande do Sul, 2013. http://hdl.handle.net/10923/5568.
Повний текст джерелаObjective: The authors present a study with the use of sodium fluorescein (SF) to enhance skull base meningiomas and perform a quantitative digital analysis of the tumors enhancement. The study intends to observe the grade of cranial base meningiomas enhancement by SF. Methods: A prospective within-subjects study was performed including twelve patients with skull base meningiomas. Digital pictures were obtained before and after the SF systemic injection, using the same light-source of the microsurgical field. The pictures were analyzed by Image Pro Plus 4. 5. 1 software, which calculated the wavelength of the sodium fluorescein pre and post injection. Results: The group of meningiomas was composed as it follows: one cavernous sinus, one olfactory groove, three petroclival, one tuberculum sellae, three sphnoid wing, one anterior clinoid and two temporal floor. The SF enhancement in all tumors was strongly positive. The digital analysis of the pictures, considering the SF wavelength pre and post injection, presented p=0. 002 (Wilcoxon T test).Conclusions: The enhancement of the skull base meningiomas by SF was consistent. The introductory results suggest the possibility of using SF as an adjuvant tool for the skull base meningioma surgery. Further studies should test the clinical application of the SF in skull base tumors.
Objetivo: Apresenta-se o primeiro estudo com o uso de Fluoresceína Sódica (FS) para contrastar meningeomas localizados na base do crânio e realiza-se uma análise quantitativa digital do contraste tumoral. O estudo tem por objetivo observar o grau de captação de FS pelos meningeomas da base do crânio.Métodos: Estudo descritivo com observação intragrupo (antes e depois), incluindo 12 pacientes com lesões da base do crânio. Fotografias digitais foram realizadas antes e após a administração sistêmica de FS, utilizando-se a mesma fonte de iluminação do campo microcirúrgico. As fotografias pré e pós-injeção de FS foram analisadas usando-se o software Image Pro Plus 4. 5. 1, que calculou o comprimento de onda da FS nas respectivas imagens. Resultados: O grupo de meningeomas foi distribuído topograficamente da seguinte forma: um do seio cavernoso, um da goteira olfatória, três petroclivais, um do tubérculo selar, três da asa do esfenóide, um da clinóide anterior e dois do assoalho temporal. O contraste dos tumores pela FS foi fortemente positivo. A análise digital das fotografias, considerando a presença do comprimento de onda da FS nas imagens obtidas pré e pós-injeção de FS, apresentou uma diferença significativa, com p=0,002 (Teste T de Wilcoxon).Conclusões: A captação da FS pelos meningeomas foi consistente. Os resultados introdutórios sugerem a possibilidade de uso da FS como uma ferramenta adjuvante para a cirurgia dos meningeomas de base de crânio. Estudos complementares são necessários para definir aplicação clínica da FS em tumores da base do crânio.
Mapes, Richard John. "The biophysical basis of accommodation in human peripheral nerve fibres." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397992.
Повний текст джерелаVermeren, Matthieu M. "Molecular basis of peripheral nerve segmentation in the chick embryo." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621857.
Повний текст джерелаUe, Hidetoshi. "Non-Invasive Assessment of Human Cardiac Autonomic Nervous System : Basic and Clinical Applications." Kyoto University, 2001. http://hdl.handle.net/2433/150745.
Повний текст джерела0048
新制・課程博士
博士(人間・環境学)
甲第9030号
人博第123号
12||125(吉田南総合図書館)
新制||人||30(附属図書館)
UT51-2001-F360
京都大学大学院人間・環境学研究科文化・地域環境学専攻
(主査)教授 森谷 敏夫, 教授 家森 幸男, 教授 津田 謹輔
学位規則第4条第1項該当
Thompson, Samantha Lee. "A genetic basis for the development of prognostic indication in childhood primitive neuroectodermal tumours." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324697.
Повний текст джерелаMedrado, Andreone Teles. "An Atlas of catfish brain - Steindachneridion parahybae (Teleostei: Siluriformes): a detailed cytoarchitectonic study of the different brain areas and nuclei as a basis for further morphological and functional studies." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-04112015-150105/.
Повний текст джерелаEsta Dissertação de Mestrado, apresenta-se estruturalmente como um Atlas, em que é apresentado um detalhado estudo citoarquitetônico do encéfalo de catfish- Steindachneridion parahybae. Para a realização deste, foram utilizados 7 juvenis de 100 dias após a eclosão, analisados por técnicas rotineiras de histologia, cujas secções coronais(transversais) - 5&um;m de espessura-, foram obtidas utilizando-se de um micrótomo rotativo, coradas com violeta de cresil e examinadas a partir de sistema digital de análise. Alguns critérios foram utilizados para classificar as diferentes massas de células do cérebro catfish, tais como: (i) o tamanho característico, forma e intensidade da coloração do pericário; (ii) padrão de densidade de agrupamento e distribuição dos corpos celulares; (iii) a presença de neurópilos ao redor dos desses agrupamentos celulares e (iv) a consistência/coerência destes agrupamentos em ambos os hemisférios dos diferentes encéfalos, então analisados. Dessa forma, são descritos aproximadamente130 massas celulares para o encéfalo de S. parahybae, as quais estão distribuídas em quatro principais regiões que, da parte rostral para caudal, são: telencéfalo, diencéfalo, mesencéfalo e rombencéfalo. Embora são observadas semelhanças entre o cérebro de S. parahybae e de outros teleósteos, nota-se, também, certas diferenças quanto às características e/ou localização das massas celulares em relação ao encéfalo de outros teleósteos, ou mesmo quando comparado com o cérebro de espécies da mesma ordem, Siluriformes. Algumas destas diferenças pode estar relacionada com a idade dos animais estudados, no entanto,também podem representar diferenças espécie-específicas, uma vez que o encéfalo adultos de S. parahybae apresentam grande similaridade citoarquitetônica, além da organização geral do encéfalo, previamente observadas em animais acima dos 100 dias após a eclosão. Portanto, como resultado deste estudo tem-se a disponibilidade de um Atlas completo do encéfalo de S. parahybae, o qual representa uma ferramenta valiosa para o estudo das conexões neurais entre diferentes áreas do encéfalo, bem como para futuras análises endócrinas, permitindo o mapeamento preciso de neuro-hormônios nesta espécie, como demonstrado ao longo deste estudo, para o hormônio liberador de gonadotropinas
Beaudoin, Danelle Rae. "T-cell signaling in response to altered myelin basic protein peptides /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8535.
Повний текст джерелаDombrowski, Mary A. "Sciatic nerve remyelination and nodal formation following olfactory ensheathing cell transplantation." Yale University, 2008. http://ymtdl.med.yale.edu/theses/available/etd-08092007-114648/.
Повний текст джерелаCarvalho, Michelle Figueiredo. "Dieta Experimental com Base nos Alimentos da Pesquisa de Orçamento Familiar (POF)- 2002/2003 Durante Gestação e Lactação: Repercussões Sobre Desempenho Reprodutivo, Dimensões Corporais e Perfil Bioquímico de Filhotes." Universidade Federal de Pernambuco, 2012. https://repositorio.ufpe.br/handle/123456789/12071.
Повний текст джерелаMade available in DSpace on 2015-03-11T19:15:50Z (GMT). No. of bitstreams: 2 Tese Michelle Carvalho Nutrição 2012.pdf: 2269037 bytes, checksum: fcecb05acf122ab934ca168e509e7260 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2012-04-11
O presente estudo avaliou os efeitos de uma dieta experimental baseada nos alimentos adquiridos para consumo pelos brasileiros segundo a Pesquisa de Orçamento Familiar (POF) 2002/2003 durante a gestação e lactação e/ou pós-desmame sobre os desempenhos maternos crescimento, desenvolvimento, adiposidade, dimensões corporais e perfil bioquímico na prole. Ratas Wistar (n= 12), alimentadas ad libitum com dieta comercial Labina®, Brasil ou dieta experimental na gestação e lactação formaram os grupos GC e GPOF. Do desmame aos 120 dias novos subgrupos foram formados: Controle-controle (GCC); controle-POF (GCP); POF-controle (GPC) e POF-POF (GPP). A significância adotada em todas as análises foi de 5%. A dieta POF aumentou a duração da gestação [GC:21,00(21,00-21,00); GPOF: 22,00(21,25-22,00)] e provocou nas mães perda de peso ao final da lactação (GC: 27,92±18,47g; GPOF: -15,66±16,90g), menor consumo alimentar, energético e de nutrientes, exceto de lipídeos. A prole GPOF apresentou menor peso ao desmame e menor comprimento naso-anal. No entanto, não diferiu nos eixos cranianos, na maioria dos reflexos e caracteres físicos e até adiantou alguns desses parâmetros: colocação pelas vibrissas [GC: 12,00 (9,00-15,00); GPOF: 9,50 (9,00-14,00)] e queda livre [GC: 18,00 (17,00-20,00); GPOF: 16,00 (13,00-18,00)] e da característica física de abertura do pavilhão auditivo [GC: 3,00 (3,00-3,00); GPOF: 2,00 (2,00-3,00)]. A dieta POF oferecida na fase perinatal e/ ou pós-desmame incrementou o ganho de peso (%) ao final do estudo (GPP=878,2±93,5%;GPC=871,7±102,9%; GCP=682,6±98,4%; GCC=678,28±91,69%), mas reduziu o peso do fígado (GPP=2,59±0,13g; GPC=2,94±0,31g; GCP=2,67±0,28g; GCC= 2,80±0,08g) e rins (GPP=0,31±0,02g; GPC=0,33±0,04g; GCP=0,30±0,01g; GCC=0,38±0,03g). Alteração na gordura visceral foi evidenciada em todos os grupos com dieta POF (GPP=16,06±1,57g; GPC=16,82±3,44g; GCP= 20,65±3,68g; GCC= 12,46±3,24g) e o GPP mostrou maior glicemia de jejum. A dieta POF causou maior agressão ao crescimento somático que ao desenvolvimento do sistema nervoso da prole e demonstrou aumento no depósito de gordura visceral, e, da glicemia se ingerida continuamente.
Lim, S. P. "Electrical basis for inhibition and excitation in non-propulsive autonomically innervated smooth muscle." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377171.
Повний текст джерелаAggarwal, Anuradha 1964. "Basis for a sympatholytic approach in the treatment of human heart failure." Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/8091.
Повний текст джерелаKharrazian, Datis. "Association between Immunological Reactivity with Tetrabromobisphenol-A and Autoimmune Target Sites of the Nervous System." Diss., NSUWorks, 2018. https://nsuworks.nova.edu/hpd_hs_stuetd/12.
Повний текст джерелаSilva, Carlos Eduardo da. "Uso de fluoresce?na s?dica em meningeomas da base do cr?nio." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2013. http://tede2.pucrs.br/tede2/handle/tede/1746.
Повний текст джерелаObjective: The authors present a study with the use of sodium fluorescein (SF) to enhance skull base meningiomas and perform a quantitative digital analysis of the tumors enhancement. The study intends to observe the grade of cranial base meningiomas enhancement by SF. Methods: A prospective within-subjects study was performed including twelve patients with skull base meningiomas. Digital pictures were obtained before and after the SF systemic injection, using the same light-source of the microsurgical field. The pictures were analyzed by Image Pro Plus 4.5.1 software, which calculated the wavelength of the sodium fluorescein pre and post injection. Results: The group of meningiomas was composed as it follows: one cavernous sinus, one olfactory groove, three petroclival, one tuberculum sellae, three sphnoid wing, one anterior clinoid and two temporal floor. The SF enhancement in all tumors was strongly positive. The digital analysis of the pictures, considering the SF wavelength pre and post injection, presented p=0.002 (Wilcoxon T test). Conclusions: The enhancement of the skull base meningiomas by SF was consistent. The introductory results suggest the possibility of using SF as an adjuvant tool for the skull base meningioma surgery. Further studies should test the clinical application of the SF in skull base tumors.
Objetivo: Apresenta-se o primeiro estudo com o uso de Fluoresce?na S?dica (FS) para contrastar meningeomas localizados na base do cr?nio e realiza-se uma an?lise quantitativa digital do contraste tumoral. O estudo tem por objetivo observar o grau de capta??o de FS pelos meningeomas da base do cr?nio. M?todos: Estudo descritivo com observa??o intragrupo (antes e depois), incluindo 12 pacientes com les?es da base do cr?nio. Fotografias digitais foram realizadas antes e ap?s a administra??o sist?mica de FS, utilizando-se a mesma fonte de ilumina??o do campo microcir?rgico. As fotografias pr? e p?s-inje??o de FS foram analisadas usando-se o software Image Pro Plus 4.5.1, que calculou o comprimento de onda da FS nas respectivas imagens. Resultados: O grupo de meningeomas foi distribu?do topograficamente da seguinte forma: um do seio cavernoso, um da goteira olfat?ria, tr?s petroclivais, um do tub?rculo selar, tr?s da asa do esfen?ide,um da clin?ide anterior e dois do assoalho temporal. O contraste dos tumores pela FS foi fortemente positivo. A an?lise digital das fotografias, considerando a presen?a do comprimento de onda da FS nas imagens obtidas pr? e p?s-inje??o de FS, apresentou uma diferen?a significativa, com p=0,002 (Teste T de Wilcoxon). Conclus?es: A capta??o da FS pelos meningeomas foi consistente. Os resultados introdut?rios sugerem a possibilidade de uso da FS como uma ferramenta adjuvante para a cirurgia dos meningeomas de base de cr?nio. Estudos complementares s?o necess?rios para definir aplica??o cl?nica da FS em tumores da base do cr?nio.
Kvarnström, Maria. "Mechanisms in inflammatory demyelinating diseases of the nervous system : immunological and methodological aspects /." Linköping : Linköpings universitet, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med892s.pdf.
Повний текст джерелаNEAL, MARY ELIZABETH. "DIAGNOSTIC PREDICTION OF EATING DISORDER PATIENTS ON THE BASIS OF MEASURES OF PERSONAL EFFECTIVENESS, FAMILY DYNAMICS AND TRADITIONAL SEX-ROLE BELIEFS (ANOREXIA NERVOSA, BULIMIA)." Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183900.
Повний текст джерелаLekholm, Emilia. "Solute Carriers in Metabolism : Regulation of known and putative solute carriers in the central nervous system." Doctoral thesis, Uppsala universitet, Funktionell farmakologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-331328.
Повний текст джерелаZibetti, C. "ALTERNATIVE SPLICING AND PHOSPHORYLATION PROVIDE A MECHANISTIC BASIS FOR FUNCTIONAL SPECIALIZATION OF LSD1/KDM1 HISTONE DEMETHYLASE IN THE CENTRAL NERVOUS SYSTEM." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150261.
Повний текст джерелаChénard, Carol Anne. "Ribonucleoprotein complexes and protein arginine methylation : a role in diseases of the central nervous sytem." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115894.
Повний текст джерелаQKI's involvement in all of these processes, lead us to examine both the protein partners and the mRNA targets of the QKI complex in order to identify potentially new pathways regulated by QKI. In doing so, we identified a novel direct protein-protein interaction with PABP and for the first time described the relocalization of QKI to cytoplasmic granules following oxidative stress. In addition, in vivo mRNA interaction studies were performed and allowed the identification of approximately 100 new mRNA targets in human glioblastoma cells. One of the targets identified was VEGF mRNA.
Another QKI target mRNA is MBP, a major protein component of the myelin sheath and the candidate auto-antigen in multiple sclerosis (MS). In vivo MBP is symmetrically dimethylated on a single arginine residue. To further establish the role of the methylation of MBP in myelination, a methyl-specific antibody and an adenovirus expressing a recombinant protein arginine methyltransferase 5 (PRMT5) was generated. We show that methylated MBP is found in areas of mature myelin and that overexpression of the PRTM5 blocked the differentiation of oligodendrocytes.
Taken together these datas implicate QKI for the first time in the process of human cancer angiogenesis and could explain the vascularization defects observed in some of the qkI mutant mice. In addition, arginine methylation of MBP may prove to have an important role in the process of myelination and in the pathogenesis of demyelination and the autoimmune reaction in diseases such as MS.
Silvas, Tania V. "Investigating the Structural Basis for Human Disease: APOBEC3A and Profilin." eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/955.
Повний текст джерелаHead, David John. "Molecular basis of nerve insensitivity resistance to pyrethroid insecticides in Heliothis virescens (Fabricius) and Helicoverpa armigera (Hübner) (Lepidoptera:Noctuidae)." Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393841.
Повний текст джерелаMorgan, H. M. C. "Developmental expression of the KCa2.3 channel subunit in the central nervous system and unravelling the molecular basis of the sAHP current regulation." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19392/.
Повний текст джерелаBaer, Matthew L. "Elucidating the Role of Endogenous Electric Fields in Regulating the Astrocytic Response to Injury in the Mammalian Central Nervous System." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4007.
Повний текст джерелаFERRARI, BEATRICE. "Un nuovo profarmaco a base di platino: il suo effetto antitumorale e nuovi approcci in vitro per comprendere nuovi target per il trattamento di tumori del sistema nervoso." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1301306.
Повний текст джерелаJacquesson, Timothée. "Tractographie des nerfs crâniens : état de l'art, développement et application en chirurgie des tumeurs de la base du crâne." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1309/document.
Повний текст джерелаTractography is a recent imaging tool that used the diffusion signal from the magnetic resonance imaging (MRI) to detect the preferential orientation of water molecules within the tissues and particularly along white fibers of the brain. This technique has caught the attention of the scientific community describing non-invasively the in vivo white matter architecture. Nonetheless, its application to fiber crossing areas or to small-scale structures, such as cranial nerves, remains inaccurate. New methods are being developed for both the acquisition and post-processing steps to provide a higher angular and spatial resolution imaging, and improve the reconstruction of fibers. In the clinical setting, the detection of the trajectory of the cranial nerves displaced by skull base tumors could be a relevant asset for the surgical strategy and the functional outcome. After reminding the basics to understand each step involved in tractography, we present the current state-of-the-art for application to cranial nerves. From 21 selected studies, we report all parameters of acquisition and tracking, algorithms of reconstruction, the design of the regions of interest, and filtering. We then develop our tractography pipeline and show its value for the surgical management through a 62 case series of various skull base tumors and two clinical images. Finally, we propose a new full-tractography approach that could be implemented in routine, notably for presurgical planning
Gruenhagen, Jason Alan. "Bioanalytical Applications of Real-Time ATP Imaging Via Bioluminescence." Washington, D.C. : Oak Ridge, Tenn. : United States. Dept. of Energy. Office of Science ; distributed by the Office of Scientific and Technical Information, U.S. Dept. of Energy, 2003. http://www.osti.gov/servlets/purl/822057-FTilZ3/native/.
Повний текст джерелаPublished through the Information Bridge: DOE Scientific and Technical Information. "IS-T 2604" Jason Alan Gruenhagen. 12/12/2003. Report is also available in paper and microfiche from NTIS.
Brabb, Thea. "The fate of MBP-specific T cells in MBP TCR transgenic mice /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/10853.
Повний текст джерелаSaarikettu, Juha. "Calcium regulation and functions of basic Helix-Loop-Helix transcription factors." Doctoral thesis, Umeå : Department of Molecular Biology, Umeå University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-537.
Повний текст джерелаAllan, Douglas Watt. "Prenatal development of the rat phrenic nerve and diaphragm, basic embryology, role of PSA-NCAM and the pathogenesis of congenital diaphragmatic hernia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0009/NQ59925.pdf.
Повний текст джерелаFlanagan, Shawn D. "Neurological Basis of Persistent Functional Deficits after Traumatic Musculoskeletal Injury." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1469031876.
Повний текст джерелаPertici, Vincent. "Récupération induite par l'implantation d'hydrogels, à base de polymères et de copolymères à blocs, suite à un traumatisme médullaire : analyse comportementale, électrophysiologique et histologique." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4026/document.
Повний текст джерелаCurrently, there is no treatment for patients with spinal cord injury. This pessimistic statement is, in part, due to the presence of a scar that prevents tissue regrowth. In this context, biomaterials (non-toxic compounds) could be implanted in order both to reduce the scar formation and to provide a growth support for nervous fibers. Among those biomaterials, many seem to induce numerous benefic effects in the rat model. We confirmed these data by the use of electrophysiological techniques. In addition, we developed a new degradable material so as to limit any long term deleterious reactions. After having synthesized our material, combining the degradable quality of the poly(lactic acid) and the mechanical properties of the poly(hydroxyethyl methacrylate), we analyzed its different characteristics and its therapeutic effects. The obtained results are encouraging. Now, it would be interesting to couple bioactive molecules or cells with our biomaterial scaffold
Carmo, Samuel Sullivan. "Sistema de gerenciamento da informação: alterações neurológicas em chagásicos crônicos não-cardíacos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/17/17140/tde-26052010-105637/.
Повний текст джерелаThis is the development of a computer information management system to support scientific studies about the nervous system of non-cardiac chronic chagasic patients. The goal is to develop the required system, by assumption of the convenience in the analysis of research results. The method used to develop this computer system, dedicated to information management of research about the neurological disorders of their human subject research, were; compose the archetypal matrix of targets and requirements elicitation of the system variants; list the attributes, qualifications and domains of its variables; draw up the choice framework of equipment and required applications for its physical and logic implementation, and; deploying it through a data modeling, an adapted entity-relationship diagram and programmable logic algorithms. As a result the required system was developed. The analytical discussion is that the computerization makes the data processing faster and safer. The more practical information management processes are: the operations of registration, queries and fields\' validations, as well as the advanced and basic queries of records, in addition to table formatting and exporting of pre-treated for statistical analysis. The logical argument is that the reliability of the recorded computationally information is increased because is insured that bias of human error is absent from most of the steps, including several the data processing operations. As end discussion, scientific studies with reasonable amount of variables and research subjects are better managed if they have a dedicated system to managing their information.
Kele, Olovsson Julianna M. V. "Regulation of midbrain dopaminergic neuron development by Wnts, sFRPs and bHLH proteins/." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-242-2/.
Повний текст джерелаFischer, Linda [Verfasser], Felix Christian [Akademischer Betreuer] Felmy, Anaclet [Akademischer Betreuer] Ngezahayo, and Evgeni [Akademischer Betreuer] Ponimaskin. "Input-Output Functions of Sensory Neurons in the Central Nervous System with Focus on the Physiological Basis underlying Information Transfer in the VNLL / Linda Fischer ; Felix Felmy, Anaclet Ngezahayo, Evgeni Ponimaskin." Hannover : Stiftung Tierärztliche Hochschule Hannover, 2020. http://d-nb.info/1224232968/34.
Повний текст джерелаCastelnovo, L. F. "MOLECULAR BASIS FOR THE DEVELOPMENT OF INNOVATIVE THERAPIES FOR PERIPHERAL NEUROPATHIES TREATMENT: ROLE AND CROSS-REGULATION OF THE GABAERGIC SYSTEM AND NEUROACTIVE STEROIDS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/465187.
Повний текст джерелаChan, Kara Y. "MECHANISMS OF TRINUCLEOTIDE REPEAT INSTABILITY DURING DNA SYNTHESIS." UKnowledge, 2019. https://uknowledge.uky.edu/toxicology_etds/29.
Повний текст джерелаMao, Weiming. "The role of bHLH gene ash1 in the developing chick eye." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/mao.pdf.
Повний текст джерелаGrenier, Etienne. "Evaluation des effets physiologiques, neurophysiologiques et comportementaux liés au port de bas médicaux de compression." Thesis, Lyon, INSA, 2013. http://www.theses.fr/2013ISAL0130.
Повний текст джерелаMedical compression therapy is recognized as an essential component in the treatment of venous diseases and is indispensable in the treatment of venous diseases at different stages of the disease (heavy legs, edema and ulcers). Although the benefit is recognized by the patients themselves and by physicians, there is at present little evidence to quantify this benefit. Against this background, the aim of this thesis is to provide more understanding and objectify the benefits of compression stockings (MCS) on in terms of physiology, neurophysiology and gait dynamics. Three areas of research were identified and studied. The first line of research is the study of the effect of compression on skin microcirculatory activity in the lower limbs using the Hematron ambulatory device. The results showed an improvement in skin blood flow activity for different classes of MCS and at different positions. These results would tend to challenge the widely accepted assumption that MCS improve venous return primarily by decreasing the cross-sectional area of (superficial or deep) veins. The second line of research involves the objectification of the improvement in the quality of life resulting from the wearing of MCS, usually this is expressed subjectively by people with venous disease. Preliminary results show that the analysis of heart rate variability highlights a relationship between the indicators of sympathovagal balance activity and the use of medical compression during the day. Given the wide dispersion in the results, this study should be carried out on a larger population to draw more reliable conclusions. The last line of research relates to the impact of MCS on the behavior and, in particular, the gait of the subject. Patients report that physical fatigue in the lower limbs is less prevalent at the end of the day with compression therapy. Our hypothesis is that the wearing of MCS has a direct impact on gait. To evaluate the kinetics of walking, we have designed, developed and validated an instrumentation involving accelerometers sensors. Preliminary tests have yielded relevant parameters characteristic of gait dynamics. The next step is to conduct an experimental campaign to objectify behavioral fatigue, with or without the wearing of medical compression, at the end of the afternoon
Hou, Tianfei. "MECHANISMS AND POTENTIAL THERAPY ON DISRUPTED BLOOD PRESSURE CIRCADIAN RHYTHM IN DIABETES." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacol_etds/26.
Повний текст джерелаDaval, Jean-Luc. "Les dérivés puriques au niveau du système nerveux central : Caractérisation de la libération des dérivés adenyliques par des préparations synaptosomales : implication possible des purines dans le mécanisme d'action des benzodiazepines." Nancy 1, 1986. http://www.theses.fr/1986NAN10045.
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