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Статті в журналах з теми "Base fragment of oscillogram"
Shuker, Sabri T. "Base-of-Skull/Infratemporal Fossa Shell Fragment Retrieval." Journal of Oral and Maxillofacial Surgery 68, no. 11 (November 2010): 2668–74. http://dx.doi.org/10.1016/j.joms.2010.05.069.
Повний текст джерелаMartínez-Salvador, Sonia, Babil Menjón, Juan Forniés, Antonio Martín, and Isabel Usón. "Trapping a Difluorocarbene-Platinum Fragment by Base Coordination." Angewandte Chemie International Edition 49, no. 25 (May 6, 2010): 4286–89. http://dx.doi.org/10.1002/anie.200907031.
Повний текст джерелаMartínez-Salvador, Sonia, Babil Menjón, Juan Forniés, Antonio Martín, and Isabel Usón. "Trapping a Difluorocarbene-Platinum Fragment by Base Coordination." Angewandte Chemie 122, no. 25 (May 6, 2010): 4382–85. http://dx.doi.org/10.1002/ange.200907031.
Повний текст джерелаCross, Simon S. J. "Improved FlexX Docking Using FlexS-Determined Base Fragment Placement." Journal of Chemical Information and Modeling 45, no. 4 (July 2005): 993–1001. http://dx.doi.org/10.1021/ci050026f.
Повний текст джерелаSechi, Leonardo A., Ilaria Duprè, Guido Leori, Giovanni Fadda, and Stefania Zanetti. "Distribution of a Specific 500-Base-Pair Fragment in Mycobacterium bovis Isolates from Sardinian Cattle." Journal of Clinical Microbiology 38, no. 10 (2000): 3837–39. http://dx.doi.org/10.1128/jcm.38.10.3837-3839.2000.
Повний текст джерелаLiverneaux, P. A., S. Ichihara, S. Hendriks, S. Facca, and F. Bodin. "Fractures and dislocation of the base of the thumb metacarpal." Journal of Hand Surgery (European Volume) 40, no. 1 (October 13, 2014): 42–50. http://dx.doi.org/10.1177/1753193414554357.
Повний текст джерелаWei, Ting-Chi. "Fragment answers in Mandarin Chinese." International Journal of Chinese Linguistics 3, no. 1 (June 7, 2016): 100–131. http://dx.doi.org/10.1075/ijchl.3.1.04wei.
Повний текст джерелаKikuchi, Hideaki, Takao Sekiya, Susumu Nishimura, and Minro Watanabe. "Rat repetitive sequence: consensus sequence ofTag1–298 base pairs fragment." Nucleic Acids Research 15, no. 19 (1987): 8107–8. http://dx.doi.org/10.1093/nar/15.19.8107.
Повний текст джерелаLin, Wei, and Ming Xu. "A Microsoft Word Documents Carving Method Base on Interior Virtual Streams." Advanced Materials Research 433-440 (January 2012): 3028–32. http://dx.doi.org/10.4028/www.scientific.net/amr.433-440.3028.
Повний текст джерелаKe, Song-Hua, and Roger M. Wartell. "Influence of Neighboring Base Pairs on the Stability of Single Base Bulges and Base Pairs in a DNA Fragment." Biochemistry 34, no. 14 (April 11, 1995): 4593–600. http://dx.doi.org/10.1021/bi00014a012.
Повний текст джерелаДисертації з теми "Base fragment of oscillogram"
Козлова, Елена Борисовна. "Подавление регенеративных автоколебаний при фрезеровании тонкостенного элемента детали концевыми цилиндрическими фрезами". Thesis, Запорожский национальный технический университет, 2016. http://repository.kpi.kharkov.ua/handle/KhPI-Press/25652.
Повний текст джерелаThe thesis for the degree of candidate of technical sciences, specialty 05.03.01 – machining processes, machines and tools. National Technical University "Kharkiv Polytechnic Institute", Kharkiv, 2016. The thesis is sanctified to the exposure of basic conformities to law of influence of oblique–angledness and differently inclined points of end–capping cylindrical milling cutter on the increase of her vibration stability and quality of a treat surface at milling of the thin–walled element of detail. Construction of measuring stand and system of evaluation of results, and also the worked out construction of experimental end–capping cylindrical milling cutter with the managed angle of slope of every tooth allowed to define influence of oblique–angledness and differently inclined points on the oscillation processes excited at milling. On results the conducted experiments qualificatory correlation is set forth distinguished speed zones of vibrations of the thin–walled element of detail. It is set that increase of angle of slope of cutting edge w from 30° to 45° promotes vibrofirmness of process of the cylindrical milling. The turn of axis of rotation of milling cutter positively influences on the regenerative oscillation damping and reduces the parameter Ra of rejection of profile of a treat surface. A flat ribbon on a back surface renders substantial influence on the decline of parameter of scope of self–excited oscillations R2. Sharpening of ribbon on the back surface of differently inclined points allows additionally to decrease the scope of self–excited oscillations. At high–speeds of milling, when self–excited oscillations degenerate, application of milling cutters with differently inclined points is not effective.
Козлова, Олена Борисівна. "Пригнічення регенеративних автоколивань при фрезеруванні тонкостінного елемента деталі кінцевими циліндричними фрезами". Thesis, НТУ "ХПІ", 2016. http://repository.kpi.kharkov.ua/handle/KhPI-Press/25648.
Повний текст джерелаThe thesis for the degree of candidate of technical sciences, specialty 05.03.01 – machining processes, machines and tools. National Technical University "Kharkiv Polytechnic Institute", Kharkiv, 2016. The thesis is sanctified to the exposure of basic conformities to law of influence of oblique–angledness and differently inclined points of end–capping cylindrical milling cutter on the increase of her vibration stability and quality of a treat surface at milling of the thin–walled element of detail. Construction of measuring stand and system of evaluation of results, and also the worked out construction of experimental end–capping cylindrical milling cutter with the managed angle of slope of every tooth allowed to define influence of oblique–angledness and differently inclined points on the oscillation processes excited at milling. On results the conducted experiments qualificatory correlation is set forth distinguished speed zones of vibrations of the thin–walled element of detail. It is set that increase of angle of slope of cutting edge w from 30° to 45° promotes vibrofirmness of process of the cylindrical milling. The turn of axis of rotation of milling cutter positively influences on the regenerative oscillation damping and reduces the parameter Ra of rejection of profile of a treat surface. A flat ribbon on a back surface renders substantial influence on the decline of parameter of scope of self–excited oscillations R2. Sharpening of ribbon on the back surface of differently inclined points allows additionally to decrease the scope of self–excited oscillations. At high–speeds of milling, when self–excited oscillations degenerate, application of milling cutters with differently inclined points is not effective.
Gorugantula, Sobha Priyadarshini. "Syntheses of fused pyrroloheterocycles, isatins, approach towards the indole fragment of nosiheptide and a base-mediated formation of 3-hydroxycarbazoles." Morgantown, W. Va. : [West Virginia University Libraries], 2009. http://hdl.handle.net/10450/10483.
Повний текст джерелаTitle from document title page. Document formatted into pages; contains xx, 242 p. : ill. Includes abstract. Includes bibliographical references (p. 137-145).
Yongsiriwit, Karn. "Modeling and mining business process variants in cloud environments." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLL002/document.
Повний текст джерелаMore and more organizations are adopting cloud-based Process-Aware Information Systems (PAIS) to manage and execute processes in the cloud as an environment to optimally share and deploy their applications. This is especially true for large organizations having branches operating in different regions with a considerable amount of similar processes. Such organizations need to support many variants of the same process due to their branches' local culture, regulations, etc. However, developing new process variant from scratch is error-prone and time consuming. Motivated by the "Design by Reuse" paradigm, branches may collaborate to develop new process variants by learning from their similar processes. These processes are often heterogeneous which prevents an easy and dynamic interoperability between different branches. A process variant is an adjustment of a process model in order to flexibly adapt to specific needs. Many researches in both academics and industry are aiming to facilitate the design of process variants. Several approaches have been developed to assist process designers by searching for similar business process models or using reference models. However, these approaches are cumbersome, time-consuming and error-prone. Likewise, such approaches recommend entire process models which are not handy for process designers who need to adjust a specific part of a process model. In fact, process designers can better develop process variants having an approach that recommends a well-selected set of activities from a process model, referred to as process fragment. Large organizations with multiple branches execute BP variants in the cloud as environment to optimally deploy and share common resources. However, these cloud resources may be described using different cloud resources description standards which prevent the interoperability between different branches. In this thesis, we address the above shortcomings by proposing an ontology-based approach to semantically populate a common knowledge base of processes and cloud resources and thus enable interoperability between organization's branches. We construct our knowledge base built by extending existing ontologies. We thereafter propose an approach to mine such knowledge base to assist the development of BP variants. Furthermore, we adopt a genetic algorithm to optimally allocate cloud resources to BPs. To validate our approach, we develop two proof of concepts and perform experiments on real datasets. Experimental results show that our approach is feasible and accurate in real use-cases
Yan, Xuan. "Structural analysis of the potential therapeutic targets from specific genes in Methicillin-resistant Staphylococcus aureus (MRSA)." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2613.
Повний текст джерелаKo, Chin-Yu, and 柯清瑀. "Classifying protein fragment of unknown structure base on amino acid sequence pattern." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/31339708471796649433.
Повний текст джерела國立臺灣大學
醫學工程學研究所
93
Protein structure prediction plays a major role in clinical research of biomedical science in the 21st century. In the past, protein structures were obtained by X-ray diffraction or nuclear magnetic resonance but both methods have technical limitation. If a fragmented protein sequence can be correctly matched to its structure, it would be more effective to infer the unknown functions of a protein with less expense and numerous problems in biomedical area may be resolved naturally. The major difficulty in developing the method of protein structure prediction lies in the selection of the protein backbone template especially when there is no homology protein to refer to, which leads to the deviation of backbone structure even though it is a local optimal structure. In this study, we proposed a new method to classify protein fragment, which not only discovered the possible structures of each protein fragment but also opened up varieties of possibilities to predict the whole protein structure. The primary idea of the proposed method is based on pattern mining of protein fragment sequences. It is motivated by the observation that there exist a finite number of specific sequence patterns in each class of protein fragments and these patterns may imply not only sequence information but possible molecular interaction. Once we found out these patterns, we could assign appropriate class to each fragment of protein and match fragments to the possible structures. If two proteins are similar in structures, it does not imply that their sequences be similar as well but using the classes characterizing different protein fragment structures to annotate that two protein sequences should be similar. Theoretically, it can reduce the structural deviation caused by slight sequence difference. Recognizing the potential drawbacks of depending on the existence of homologous proteins commonly found in conventional secondary and tertiary protein structure predictions, in the proposed method, we deliberately dropped the step of finding homologous proteins but still kept the concepts of homology modeling. The prediction accuracy in test data is about 78% and in whole sequence cases is more than 77%.
Cunha, Andreia Espírito Santo. "Towards the discovery of novel anti-Influenza agents using a reverse virtual fragment screening approach." Master's thesis, 2017. http://hdl.handle.net/10316/83182.
Повний текст джерелаOs vírus influenza são agentes patogénicos responsáveis por doenças respiratórias – gripe - que afetam a população mundial e caracterizadas por elevada morbilidade e significativa mortalidade. As infeções provocadas pelo vírus da gripe podem ser controladas através de vacinação e medicamentos antivirais. No entanto, as vacinas precisam de reformulação e administração anuais e oferecem proteção limitada. O rápido aparecimento de estirpes de influenza resistentes aos fármacos atualmente comercializados contra o vírus influenza A realça a necessidade de desenvolver novas classes de antivirais.Vários estudos funcionais e estruturais demonstraram que a proteína não-estrutural 1 (NS1) do vírus Influenza é um potencial alvo terapêutico. A NS1 tem um papel principal na replicação do vírus e na supressão do sistema. Esta proteína multifuncional, que participa em interações proteína-RNA e proteína-proteína, e altamente conservada é constituída por dois domínios: o domínio N-terminal constituído por 73 aminoácidos que interage com o ácido ribonucleico (RNA) de dupla cadeia (RBD) e o domínio C-terminal denominado de domínio efetor (ED). Com o intuito de descobrir compostos orgânicos com capacidade de inibir a função da NS1, no presente projeto foi desenvolvido e implementado um protocolo que combina abordagens computacionais e experimentais. Primeiro, e para permitir a validação experimental de novos inibidores, caracterizou-se os domínios RBD e ED da NS1 através de várias técnicas experimentais, incluindo Calorimetria de Varrimento Diferencial (DSC), Dicroísmo Circular (CD), Cromatografia de Exclusão Molecular acoplada a um detetor multiangular de dispersão de luz (SEC-MALS) e Ressonância Magnética Nuclear (RMN). Os dados experimentais mostram que, em solução, o ED encontra-se em estado monomérico e o RBD em dímero. O espectro de RMN HSQC 1H-15N do RBD-NS1 revela uma grande dispersão de desvios químicos, demonstrando o alto potencial desta técnica para o rastreio de compostos ligantes através da análise da perturbação dos desvios químicos.A componente computacional deste protocolo assenta na identificação de regiões à superfície da NS1 propensos à interação com moléculas com características semelhantes às de fármacos, seguida do rastreio de pequenas moléculas orgânicas (fragmentos) associados a locais de ligação com elevada similaridade química e topológica de uma biblioteca de estruturas proteicas. As potenciais interações dos fragmentos assim identificados com a NS1 são analisadas mediante acoplagem (docking) dos mesmos aos locais de ligação previstos para esta proteína. Num passo final, e após a seleção e obtenção dos fragmentos mais promissores a partir de fornecedores à volta do mundo, realizou-se a validação experimental das interações por RMN. Na fase final deste projeto já foram testados dois fragmentos e é possível concluir a partir destes resultados preliminares o sucesso do protocolo.
Influenza viruses are major human pathogens responsible for respiratory diseases affecting millions of people worldwide and characterized by high morbidity and significant mortality. Influenza infections can be controlled by vaccination and antiviral drugs. However, vaccines need annual reformulation and administration, and provide limited protection. The rapid emergence of influenza virus strains resistant to current antiviral drugs directed against influenza A highlights the need for the development of new classes of antivirals. Toward this end, several structural and functional studies of influenza non-structural protein 1 (NS1) have identified this protein as a potential therapeutic target. This highly conserved and multifunctional protein is composed of two distinctive structural domains, a 73-residue N-terminal double stranded RNA-binding domain (RBD) and a C-terminal effector domain (ED).With the purpose of discover organic compounds with the ability to inhibit NS1, a protocol combining computational and experimental approaches was designed. First, and to allow the experimental validation of new inhibitors, we have characterized the RBD and ED domains of NS1 with several experimental techniques, such as Differential Scanning Calorimetry (DSC), Circular Dichroism (CD), Size-Exclusion Chromatography coupled with Multi-Angle Light Scattering (SEC-MALS) and Nuclear Magnetic Resonance (NMR). The experimental data shows that in solution the ED is in a monomeric state and RBD is a dimer. The 1H-15N HSQC spectrum of RBD-NS1 shows large chemical shift dispersion and thus presents high potential to be used in compound screening based on chemical shift perturbation experiments. The core of the computational protocol is based on the identification of regions in the NS1 surface with molecules with similar features to drugs, followed by screening of small organic molecules (fragments) associated with binding sites with high chemical similarity from a protein database. The possible interactions of the fragments with NS1 are analyzed using docking of the fragments with the binding site of NS1. In the final step, after the selection of the most promising fragments we proceed to the experimental validation using NMR experiments. We tested two fragments and the preliminary results show the success of the protocol.
Bastien, Dominic. "Découverte d'inhibiteurs de la dihydrofolate réductase R67 impliquée dans la résistance au triméthoprime." Thèse, 2012. http://hdl.handle.net/1866/8917.
Повний текст джерелаTrimethoprim (TMP) is a common antibiotic which is used since the 60's. TMP is an inhibitor of the bacterial chromosomal dihydrofolate reductase (DHFR). This enzyme catalyses the reduction of the dihydrofolate (DHF) to tetrahydrofolate (THF) which is essential to the biosynthesis of purines thus to cellular proliferation. Bacterial TMP resistance is documented since about 30 years. One of the cause of this resistance comes from the fact that certain bacteria express a plasmidic DHFR, the R67 DHFR, which confers TMP resistance. The R67 DHFR is not inhibited by TMP and can replace the chromosomal DHFR when the latter is inhibited by TMP. The discovery of R67 DHFR inhibitors would allow to break the trimethoprim resistance granted by R67 DHFR. In order to discover R67 DHFR inhibitors, fragment based design and virtual screening approaches were selected. By fragment based design, seven simple compounds with a low molecular mass which inhibited weakly R67 DHFR (fragments) were identified. From these fragments, more complex and symmetrical compounds inhibiting R67 DHFR in the micromolar range were identified. Kinetic studies showed these inhibitors were competitive and at least two molecules bind simultaneously to the active site of the R67 DHFR. Test of the micromolar inhibitors analog showed that the presence of carboxylate, benzimidazole and the length of the molecule all have an effect on the potency of the inhibitors. Molecular docking of the inhibitors, supported by in vitro data, were used to develop a model which suggest that residue like Lys32, Gln67 and Ile68 would be involved in the binding of the inhibitors to the R67 DHFR. Virtual screening of the 80 000 compound Maybridge library with Moldock software, followed by in vitro test of the best candidate, identified four micromolar inhibitors which are chemically distinct from the inhibitor beforehand identified. A second virtual screening of a 6 million compounds bank identified three micromolar inhibitors which are also distinct from the inhibitor beforehand identified. vi These results offer a basis which will allow further development of more potent inhibitors with more acceptable pharmacologic properties in order to develop an antibiotic which would break the TMP resistance granted by the R67 DHFR.
Casu, Bastien. "Caractérisation biochimique, structurale et inhibition du système de sécrétion de type IV par l’étude des protéines VirB8." Thèse, 2018. http://hdl.handle.net/1866/20745.
Повний текст джерелаЧастини книг з теми "Base fragment of oscillogram"
Zhang, Jing, Honglei Zhuang, Yanglei Song, Jiawei Han, Yutao Zhang, Jie Tang, and Juanzi Li. "Knowledge Fragment Enrichment Using Domain Knowledge Base." In Communications in Computer and Information Science, 274–86. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-2993-6_24.
Повний текст джерелаHaase, Christoph, and Jakub Różycki. "On the Expressiveness of Büchi Arithmetic." In Lecture Notes in Computer Science, 310–23. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-71995-1_16.
Повний текст джерелаKao, Chien-Hsiang, and Fang-Yie Leu. "Prediction of the Fragment of Video Streamed to Mobile Phones Under a 5G Network Base Station." In Innovative Mobile and Internet Services in Ubiquitous Computing, 493–501. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-61542-4_47.
Повний текст джерелаBoelens, R., R. M. Scheek, R. M. J. N. Lamerichs, J. de Vlieg, J. H. van Boom, and R. Kaptein. "A Two-Dimensional NMR Study of the Complex of lac Repressor Headpiece with a 14 Base Pair lac Operator Fragment." In DNA—Ligand Interactions, 191–215. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5383-6_14.
Повний текст джерела"Analysis Techniques." In DNA Fingerprinting, edited by Lorne t. Kirby. Oxford University Press, 1993. http://dx.doi.org/10.1093/oso/9780716770015.003.0009.
Повний текст джерелаOmagano Itenge, Theopoline. "Application of PCR Technique to Detect Polymorphism of the KRTAP1.1 Gene in Three Sheep Breeds - A Review." In Analytical Chemistry - Advancement, Perspectives and Applications. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96941.
Повний текст джерелаGawlikowski, Michał. "Bagatelles épigraphiques." In Classica Orientalia. Essays presented to Wiktor Andrzej Daszewski on his 75th Birthday, 183–91. DiG Publisher, 2011. http://dx.doi.org/10.37343/pcma.uw.dig.9788371817212.pp.183-191.
Повний текст джерелаHogan, Aidan, Andreas Harth, and Axel Polleres. "Scalable Authoritative OWL Reasoning for the Web*." In Semantic Services, Interoperability and Web Applications, 131–77. IGI Global, 2011. http://dx.doi.org/10.4018/978-1-60960-593-3.ch006.
Повний текст джерела"Cutthroat Trout: Evolutionary Biology and Taxonomy." In Cutthroat Trout: Evolutionary Biology and Taxonomy, edited by Dennis K. Shiozawa, R. Paul Evans, Derek D. Houston, and Peter J. Unmack. American Fisheries Society, 2018. http://dx.doi.org/10.47886/9781934874509.ch6.
Повний текст джерелаLi, M., and T. Jiang. "Shortest Common Superstrings." In Pattern Matching Algorithms. Oxford University Press, 1997. http://dx.doi.org/10.1093/oso/9780195113679.003.0011.
Повний текст джерелаТези доповідей конференцій з теми "Base fragment of oscillogram"
Lu, Diqun, and Jiamin Zhao. "Design of High-Isolation Fragment-Type 5G Base Station Antennas with MOEA/D-GO." In 2020 International Symposium on Antennas and Propagation (ISAP). IEEE, 2021. http://dx.doi.org/10.23919/isap47053.2021.9391504.
Повний текст джерелаOkun', Dmitriy. "FORMAL REPRESENTATION OF KNOWLEDGE ABOUT MEDICAMENTAL THERAPY FOR ISCHEMIC HEART DISEASES (detail)." In XIV International Scientific Conference "System Analysis in Medicine". Far Eastern Scientific Center of Physiology and Pathology of Respiration, 2020. http://dx.doi.org/10.12737/conferencearticle_5fe01d9bce39f8.78028503.
Повний текст джерелаBednarczyk, Bartosz, and Sebastian Rudolph. "Worst-Case Optimal Querying of Very Expressive Description Logics with Path Expressions and Succinct Counting." In Twenty-Eighth International Joint Conference on Artificial Intelligence {IJCAI-19}. California: International Joint Conferences on Artificial Intelligence Organization, 2019. http://dx.doi.org/10.24963/ijcai.2019/212.
Повний текст джерелаMahfuz, Hassan, Yuehui Zhu, Wahid A. Mamun, Anwarul Haque, and Shaik Jeelani. "Failure Analysis of Hybrid Armor Under High Velocity Impact." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-1964.
Повний текст джерелаSingh, Gurjap, Nicholas Hentges, Damion Johnson, and Albert Ratner. "Experimental Investigation of Combustion Behavior of Biodiesel-Water Emulsion." In ASME 2019 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/imece2019-10917.
Повний текст джерелаKobzev, Artem. "THE FIRST INFORMATION ABOUT THE YI-JING IN RUSSIA." In 9th International Conference ISSUES OF FAR EASTERN LITERATURES. St. Petersburg State University, 2021. http://dx.doi.org/10.21638/11701/9785288062049.27.
Повний текст джерелаЗвіти організацій з теми "Base fragment of oscillogram"
Levisohn, Sharon, Maricarmen Garcia, David Yogev, and Stanley Kleven. Targeted Molecular Typing of Pathogenic Avian Mycoplasmas. United States Department of Agriculture, January 2006. http://dx.doi.org/10.32747/2006.7695853.bard.
Повний текст джерела