Дисертації з теми "BAM 1"
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Thomson, Belinda. "A cost effective grassland management strategy to reduce the number of bird strikes at the Brisbane airport." Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/16576/1/Belinda_Thomson_Thesis.pdf.
Повний текст джерелаMatar, Gladys. "Caractérisation biophysique de peptides riches en tryptophane à l'interface air-eau : apport de l'optique non linéaire." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10249.
Повний текст джерелаMembrane proteins are extremely rich in aromatic amino acids, like tryptophan (W). This particularity is found in many antimicrobial peptides and in several virus fusion proteins. An example of these fusion proteins is the HIV-1 envelop glycoprotein, the gp41. It is clear that the W residues are implicated in membrane perturbation and pore formation. The aim of this work was the investigation of the W residue role in such activities, using the nonlinear optic. First, we determined the W hyperpolarizabilité (nonlinear potential) by the Hyper Rayleigh Scattering (HRS). Then, the evolution of the nonlinear signal of small synthetic peptides, as function of the increasing number of their W residues, was demonstrated. These results allowed us to follow the W residue involvement of two peptides, K3W4 and gp41W, in the interaction with lipids monolayer at the air-water interface, using the second harmonic generation (SHG). The influence of such interaction in the peptide structure and orientation was determined using the PM-IRRAS. In conclusion, we showed the coherence between the SHG signal variation, due to the W orientation changes, and the PMIRRAS spectra modification, due to the gp41W helix orientation changes
Moraes, Marli Leite de. "Filmes de Langmuir e vesículas multilamelares de fosfolipídios e suas interações com um peptídeo oriundo da proteína p24 do HIV-1." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-18062008-115445/.
Повний текст джерелаThe investigation of the interaction mechanisms between the viruses and the host cells brings relevant information for the identification of targets on the development of drugs to prevent the penetration and/or development of the viruses. Peptides designed from viral proteins have been developed and tested on its capacities of inhibiting the merging process of the virus with the host cell. Some of them are in clinical evaluation. Antibodies against the protein p24 of the HIV-1 have been detected in the serum of HIV-positive patients, and they are able to recognize short peptide sequences of this protein. In this work, it was analyzed the interaction between a peptide sequence corresponding to amino acids 196-224 (AAMQMLKETINEEAAEWDRVHPVHAGPIA) of the protein p24, called p24- 1, and biomimetic systems. The systems used were Langmuir films (monolayers) of dipalmitoyl phosphatidyl choline (DPPC) and dipalmitoyl phosphatidyl glycerol (DPPG) and multilamelar vesicles (MLVs) of DPPC. p24-1 is found disorganized in watery solution, but with the interaction with the MLVs of DPPC it had induced a conformation ?-helix, according to the circular dichoism spectra (CD). This characteristic was confirmed by the prediction of ?-helix followed by an unordered structure with 11 residues of p24-1. The isotherms of pressure and potential of surface of the DPPC monolayers were affected by the presence of 0,05% mo1 of p24-1, with an expansion of approximately 5%. For concentrations above 0,5% mol of p24-1 the expansion was 20%, with saturation of the concentration effect. The expansion effect was followed by a morphologic alteration of the monolayers, studied with microscopy of the Brewster angle (BAM). The incorporation of p24-1 prevents the formation of large domains of DPPC. The cooperative effect caused in the phospholipid monolayer by p24-1 suggests that this peptide has a potential in the antiviral activity, once its participates on the expansion of the host cell membrane.
Newton, Barry Edward. "Thermal profile of a near-adiabatic compression process in a cylindrical tube and establishment of critical control elements for repeatable process control." Thesis, Queensland University of Technology, 2011. https://eprints.qut.edu.au/48340/1/Barry_Newton_Thesis.pdf.
Повний текст джерелаWestblom, Jesper. "Slakthusgatan 1 : Bad i hundraårig industrihall." Thesis, KTH, Arkitektur, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-67301.
Повний текст джерелаAnger, Moris. "Expressão de proteínas da apoptose em melanoma cutâneo primário." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5158/tde-15042009-162410/.
Повний текст джерелаCutaneous melanoma still constitutes the main cause of skin cancer death in developed world. Clinical behavior variability of this neoplasia has been only partially explained by clinical and histological aspects, and identification of biological variables can be important for determining specific risk groups. Sixty nine (69) patients with mild to severe primary cutaneous melanoma treated in 1990-2007 were studied aiming at (a) verifying clinical epidemiological aspects, (b) generating a Tissue microarray (TMA) for characterizing proteins expression of cutaneous melanoma > 1.0 mm, (c) analyzing the immunohistochemical expression of the apoptosis proteins Bcl2, Bax, Bak, Apaf-1, Caspase 3, Caspase 9, Caspase 8, FasL e Fas in 10 control nevi and in primary melanomas with thickness 1mm, (d) and correlating these proteins expression with the disease prognosis. Results have ratified known epidemiological date on gender, age and lesion localization as well as the correlation between the disease prognosis and the Breslow\'s indexes. Analysis of the composite scores relating to apoptosis proteins has revealed that their immunohistochemical profile seems to be not significant for determining the disease prognosis, since no differences in proteins expression were found when compared patients with and without disease dissemination. Alterations in proteins expression suggesting their role in the genesis as well as in the prognosis of primary melanoma were not evidenced. Immunohistochemical profile with pro-apoptosis trend seems to indicate other factor as responsible for the neoplasia growth and dissemination
Skeen, Victoria Rachel. "Investigating the functions of BAG-1 in colorectal tumorigenesis : implications of BAG-1-mediated suppression of TGF-B1 production." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535479.
Повний текст джерелаRockvam, Margaux. "Caractérisation de microstructures de joints brasés avec les alliages BCu-1, BAg-13a, BAu-4, BAu-6, BNi-1a, BNi-2, BNi-3 et Palnicro 36M ayant pour métal de base un superalliage base nickel." Mémoire, École de technologie supérieure, 2011. http://espace.etsmtl.ca/911/1/ROKVAM_Margaux.pdf.
Повний текст джерелаYang, Xiaolong. "Molecular cloning and characterization of human BAG-1." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0016/NQ47506.pdf.
Повний текст джерелаCutress, Ramsey Ian. "BAG 1 expression and function in breast cancer." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289513.
Повний текст джерелаGagnon, Josée. "Étude des gènes Bax inhibitor-1 du peuplier." Mémoire, Université de Sherbrooke, 2006. http://savoirs.usherbrooke.ca/handle/11143/4726.
Повний текст джерелаGagnon, Josée. "Étude des gènes Bax inhibitor-1 du peuplier." [S.l. : s.n.], 2006.
Знайти повний текст джерелаFerreira, Paula Irusta. "Estudo de respostas fibróticas e apoptóticas em rins de ratos tratados com aldosterona." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/74/74135/tde-16032017-103812/.
Повний текст джерелаIn order to understand the aldosterone (Aldo) involvement in renal injury, the objective of this project was to evaluate the effect of Aldo chronic treatment on renal function and renal arterioles histology, trying to correlate the findings with the regulatory genes of fibrosis and apoptosis. Aldo did not change the physiological parameters, BP, glomerular filtration rate (estimated by creatinina clearance), proteinuria and cortical arterioles morphology. However, Aldo increased mRNA expression for TGF-β1, PAI-1 and BAX in renal tissue, as well as TUNEL-positive cell count in glomeruli. MR receptor antagonism (by spironolactone) abolished only the hormonal effect on the mRNA expression for BAX and degraded DNA labeling (TUNEL); whereas GR antagonism (by RU 486) reduced or abolished all Aldo effects. The results indicated that Aldo can induce early responses on renal tissue remodeling, without altering renal function or BP. These responses were salt independent and involved MR and GR receptors.
Yang, Ling. "Bcl-2-associated athanogene-1 (BAG-1) Modulates the Endoplasmic Reticulum Stress Response in Chondrocytes." Kent State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=kent1175103480.
Повний текст джерелаGallegos, María Isabel, and Osiris Melo. "Técnicas de Servicio y Bar (HO24), ciclo 2013-1." Universidad Peruana de Ciencias Aplicadas - UPC, 2013. http://hdl.handle.net/10757/271337.
Повний текст джерелаWoods, Nicholas Taylor. "Regulation of bax activation and apoptosis by src and acetylated mutant p53." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002641.
Повний текст джерелаNayak, Soumya Sambit. "Continuum Analytical Shape Sensitivity Analysis of 1-D Elastic Bar." Thesis, Virginia Tech, 2021. http://hdl.handle.net/10919/101764.
Повний текст джерелаMaster of Science
When solving an optimization problem, the extreme value of the performance metric of interest is calculated by tuning the values of the design variables. Some optimization problems involve shape change as one of the design variables. Change in shape leads to change in the boundary locations. This leads to a change in the domain definition and the boundary conditions. We consider a 1-D structural element, an elastic bar, for this study. Subsequently, we demonstrate a method for calculating the sensitivity of solution (e.g. displacement at a point) to change in the shape (length for 1-D case) of the elastic bar. These sensitivities, known as shape sensitivities, are critical for design optimization problems. We make use of continuum analytical shape sensitivity analysis to derive three variational formulations to compute these shape sensitivities. The accuracy and convergence of solutions is verified using a finite element analysis code. In future, the approach can be extended to multi-dimensional structural and fluid domain problems.
Coldwell, Mark J. "Identification and functional analysis of internal ribosome entry segments in Apaf-1 and BAG-1 mRNAs." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29645.
Повний текст джерелаAbdel-Magied, Midhat. "Bar fractures in induction machines." Thesis, Imperial College London, 1986. http://hdl.handle.net/10044/1/37911.
Повний текст джерелаWood, Jemma Claire. "The function of Bag-1 proteins in epidermal squamous cell carcinoma." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550326.
Повний текст джерелаGlanville, Julie M. "Cytotoxic T-cells in HIV-1 : "the good" and "the bad"." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:5426d2c2-5a59-47da-a615-105aa2a6e9e8.
Повний текст джерелаFox, Helen Mary. "Toca-1 driven actin polymerisation at membranes." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275610.
Повний текст джерелаLim, Bao Tung Michelle. "Performing morality : a framework for assessing the moral significance of selected works of postdramatic performance." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/76539/1/Bao%20Tung%20Michelle_Lim_Thesis.pdf.
Повний текст джерелаPage, Charlotte Anne Margaret. "Consequences of BAG-1 isoform over-expression on keratinocyte motility and stratification." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441319.
Повний текст джерелаPagé, Viviane. "Évaluation du rôle de la protéine BAG-1 dans le cancer ovarien." Mémoire, Université de Sherbrooke, 2003. http://savoirs.usherbrooke.ca/handle/11143/3354.
Повний текст джерелаChaîné, Marie-Andrée. "Étude de l'expression d'AtBI-1 lors de la mort cellulaire programmée causée par les UV-C." Mémoire, Université de Sherbrooke, 2011. http://savoirs.usherbrooke.ca/handle/11143/4908.
Повний текст джерелаPing, Alistair C. "Why good people do bad things in business." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/114002/1/Alistair_Ping_Thesis.pdf.
Повний текст джерелаPickering, Becky M. "Structural, functional and mechanistic analysis of the Bag-1 internal ribosome entry site." Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/29686.
Повний текст джерелаWitcher, Michael. "Interaction of the anti-apoptotic protein BAG-1 with the vitamin D receptor." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0010/MQ52698.pdf.
Повний текст джерелаBrunn, Jonathan. "Investigation of Possible Novel Peptide Inhibitors to BAG-1 Based On Peptidyl-Biomimetics." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2942.
Повний текст джерелаMouchel, Myckael. "Développement de jonctions tunnel magnétiques bas bruit pour les capteurs de champ magnétique." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAY104.
Повний текст джерелаMagnetic tunnel junctions based magnetic field sensors are one of the most promising solutions in the framework of electronic components miniaturization. Crocus Technology, the industrial stakeholder of this thesis, has been designing some of the market smallest TMR sensors for several years. Despite their good sensitivity, they exhibit a large 1/f noise, deteriorating their capability to detect low magnetic fields. This thesis falls within a context of noise reduction and detection improvement of the sensors. In-depth noise studies of existing sensors have been performed in order to better apprehend the origins of such noise. These studies have been carried out thanks to a specifically designed experimental bench allowing simultaneous noise and magneto-electrical characterizations of the devices. Thereby, we have been able to link the observed noise to the response of the sensors under specific magnetic field conditions by developing an illustrative model based on “magnetic-to-noise fingerprint of the sensors”. This thesis was further completed by a 6-sigma project, led by the author, which allowed us to implement the needful solutions to answer an ambitious objective of noise reduction. The detectivity has been improved by nearly two orders of magnitude, thus reaching 13 nT/√Hz at 10 Hz in a few months, without deteriorating the integrability of the sensors while satisfying industrial constraints
Dzabic, Miran. "Water Circulation And Yacht Carrying Capacity Of Fethiye Bay." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614948/index.pdf.
Повний текст джерелаCombes, Alexis. "Caractérisation du rôle de BAD-LAMP comme chaperonne des "Toll like receptors" au sein des cellules dendritiques plasmacytoïdes humaines." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4057.
Повний текст джерелаHuman plasmacytoïd dendritic cells (pDCs) have been shown to be the principal producer of type-I interferons (IFNs) following intracellular TLRs stimulation. Upon activation, pDCs tightly control TLRs sub-cellular localization in specialized endosomes, leading to sequential programs of cytokines production: a first rapid wave of type-I IFN, due to IRF signalling from early endosomes, followed by pro-inflammatory cytokines production, dependent on NfκB signalling from late endosomal compartments. BAD-LAMP/LAMP5, an atypical member of the LAMP protein family, is brain specific in mice. In Human, BAD-LAMP is also expressed in pDCs. We reveal here a novel step of TLR regulation mediated by BAD-LAMP, that controls TLR9 access to, and signalling from, specialized subsets of endosomes in human pDCs. Upon CpG stimulation, BAD-LAMP and TLR9 follow a common endocytic sorting step, in order to reach early, IRF-signalling, VAMP3+ endosomes. BAD-LAMP silencing alters TLR9 traffic and promotes its retention in VAMP3+ endosomes, while ectopic BAD-LAMP expression triggers accelerated TLR9 transport to LAMP1+ lysosomes. Retention in VAMP3+ endosomes impacts directly on TLR9 signalling by increasing IFN production and decreasing TNFα. Importantly, we found that BAD-LAMP expression is down-regulated by IFN exposure. Conversely, pDCs treated with tumour supernatants or pDCs infiltrating human breast tumors, present both sustained BAD-LAMP expression, and defect in IFN production. BAD-LAMP is therefore an essential regulator of TLR9 transport in human pDCs and a marker of TLR9 signalling efficiency under pathological conditions
Lehmkuhl-Dakhwe, K. Virginia. "Regulation of p53, p21, ARF, BIM, and BAX by the Transcription Factor Trip-Br1." Ohio University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1194549826.
Повний текст джерелаHenriques, Mariana Nogueira. "IDENTIDADE FEMININA GAÚCHA: REPRESENTAÇÕES DE GÊNERO NOS PROGRAMAS REGIONAIS BAH!" Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/6370.
Повний текст джерелаThis research discusses which senses about the identity of the gaucha women are mobilized by RBS TV, from the special programs "Bah! A very gaucho program", Bah! I Am from the South" and "Bah! A very special fandango", shown on September 20th 2013 and 2014 and on September 19th 2015, respectively. The main objective is to analyze the ways in which the senses about the gaucha women are produced, which contribute to the construction and representation of this identity. The specific objectives are: to verify the production conditions that contribute to build this identity in the programs; recognize the elements used by RBS TV to represent the female characters of the program; identify the discourses used by RBS TV in Bah! for the representation of the gaucho identity, particularly the identity of the woman; and characterize the identity processes that update the representation of contemporary gaucho from the identity of the woman. For this purpose, by developing an own methodological model, from the perspective of the cultural studies, we conducted a cultural media analysis to observe our object through three main instances: television making, textual products and the context in which it appears. From the research we infer that the three main senses: concealment, objectification and masculinization form a stereotypical female identity. Also, we realize that the special programs follow the intention of perpetuating a hegemonic masculine identity transmitting a false idea of female empowerment, seeking to generate audience and recognition.
A presente pesquisa problematiza quais os sentidos sobre a identidade da mulher gaúcha são mobilizados pela RBS TV, a partir dos especiais Bah! Um programa muito gaúcho , Bah! Eu Sou do Sul e Bah! Um fandango muito especial , exibidos em 20 de setembro de 2013 e 2014 e 19 de setembro de 2015, respectivamente. O objetivo central é o de analisar os modos como são produzidos os sentidos sobre a mulher gaúcha, que contribuem para a construção e representação desta identidade. Como objetivos específicos temos: verificar as condições de produção que contribuem para a configuração desta identidade nos programas; reconhecer os elementos utilizados pela RBS TV para representar as personagens femininas do programa; identificar os discursos utilizados pela RBS TV, em Bah! para a representação da identidade gaúcha, em especial da identidade da mulher; e caracterizar os processos identitários que atualizam a representação do gaúcho contemporâneo a partir da identidade da mulher. Para isso, através da elaboração de um modelo metodológico próprio, com base na perspectiva dos estudos culturais, realizamos uma análise cultural-midiática para observar nosso objeto através de três grandes instâncias: o fazer televisivo, os produtos textuais e o contexto em que está inserido. Da pesquisa inferimos que os três principais sentidos: ocultamento, objetificação e masculinização formam uma identidade feminina estereotipada. Além disso, percebemos que os especiais atuam na intenção de perpetuar uma identidade hegemônica e masculina transmitindo uma falsa ideia de empoderamento feminino, na busca por gerar audiência e reconhecimento.
Larsen, Genevieve Ruth. "Modelling hydrodynamic processes within Pumicestone Passage, Northern Moreton Bay, Queensland." Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/16634/1/Genevieve_Larsen_Thesis.pdf.
Повний текст джерелаMartinez, Sandrine. "Palaeoecology of the Mount Etna bat fauna, coastal Eastern Queensland." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/40979/1/Sandrine_Martinez_Thesis.pdf.
Повний текст джерелаBach, Robert [Verfasser]. "Die Abwägung gemäß § 1 Abs. 7 BauGB nach Erlass des EAG Bau / Robert Bach." Frankfurt : Peter Lang GmbH, Internationaler Verlag der Wissenschaften, 2012. http://d-nb.info/1042422680/34.
Повний текст джерелаClemo, Nadine Kathryn. "The role of the anti-apoptotic protein BAG-1 in colorectal tumour cell survival." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441659.
Повний текст джерелаDearing, Kathryn Margaret. "Low-calcium pyroxene-melt equilibria at 1 bar : an experimental study in natural systems." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/14762.
Повний текст джерелаCulshaw, Abigail. "Immunodominant CD8+ T cell responses to HIV-1 infection : 'the good and the bad'." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:ec9381fc-c732-4977-a33c-290b06e45def.
Повний текст джерелаInamdar, Kaushik. "Role of I-BAR proteins and membrane curvature in HIV-1 assembly and release." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT032.
Повний текст джерелаDuring the HIV assembly and budding, the plasma membrane undergoes a curvature driven by HIV-1 Gag self-assembly at the assembly site towards the exterior of the cell. However, the multimerization of Gag may not be sufficient and Gag may need to recruit cell factors for inducing local membrane curvature. We recently reported that the HIV-1 Gag particle release was dependent on the activation of the signalling pathway Rac1/IRSp53/Wave2/Arp3 in Jurkat T cells and primary blood lymphocytes. This cellular complex, when activated, is recruited to the cell plasma membrane and promotes the recruitment of actin branching, actin polymerisation and membrane remodelling in lamellipodia. In particular, the protein IRSp53 contains an I-BAR domain capable of inducing membrane curvature via the recognition of the plasma membrane phospholipide PI(4,5)P2. This phospholipid is also specifically recognized by the N-terminal Matrix domain of Gag and is a lipidic cofactor of Gag targeting to the plasma membrane and of HIV-1 assembly. This research project aimed at characterizing the cellular and molecular mechanisms of IRSp53 involvement in HIV-1 Gag assembly in CD4 T cells and HEK293T cells. Our results show that IRSp53 is associated with viral particles and that its knockdown by siRNA decreases HIV-1 release in T lymphocytes and HEK293 T cells. Electron microscopy of cells knocked down for IRSp53 revealed a striking phenotype of viral buds arrested at an early stage of assembly. Immunoprecipitation of IRSp53 showed a p6 independent pulldown of HIV-1 Gag, indicating intracellular complexing of Gag and IRSp53. Cellular fractionation and membrane flotation showed that IRSp53 recruitment to cellular membrane doubles upon expression of HIV-1 Gag. Dual colour single molecule PALM/STORM microscopy and subsequent analyses showed IRSp53 in close proximity to Gag clusters. We also found specific incorporation of IRSp53 in HIV-1 Gag particles as compare to other I-BAR proteins, a phenomenon dependent on its IBAR domain. As the I-BAR domain is involved in membrane curvature, we then probed this aspect of IRSp53 involvement in HIV-1 assembly. Analysis of electron microscopy images revealed a curvature defect for buds from IRSp53 knocked out cells. Concomitant studies in cell free in vitro GUV systems also indicated a role for IRSp53 induced membrane curvature in Gag membrane binding. These results affirm the essential role of IRSp53 in the early stages of HIV-1 assembly. Finally as IRSp53 is a vital player in scaffolding actin signaling proteins, we established a role for activated Rac1 in IRSp53 membrane recruitment downstream of HIV-1 Gag, and test the involvement of the RacGEF Tiam1 in HIV-1 particle production. Super resolution microscopy also reveals the presence of actin nanostructures at HIV-1 assembly sites. All these results highlight the novel and essential role of the membrane curving I-BAR protein IRSp53, and the mobilization of cortical actin, in the late phases of HIV-1 replication
Dong, Quan. "HEMTs cryogéniques à faible puissance dissipée et à bas bruit." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112035.
Повний текст джерелаTransistors with low noise level at low frequency, low-power dissipation and operating at low temperature (≤ 4.2 K) are currently non-existent, however, they are widely required for realizing cryogenic preamplifiers which can be installed close to sensors or devices at a temperature of few tens of mK, in astrophysics, mesoscopic physics and space electronics. Research conducted over many years at LPN aims to a new generation of high-performance cryogenic HEMTs (High Electron Mobility Transistors) to meet these needs. This thesis, through the collaboration between the CNRS/LPN and the CEA/IRFU, aims for the realization of cryogenic preamplifiers for microcalorimeters at 50 mK.The work of this thesis consists of systematic characterizations of electrical and noise parameters of the HEMTs (fabricated at LPN) at low temperatures. Based on the experimental results, one of the low-frequency-noise sources in the HEMTs has been identified, i.e., the sequential tunneling part in the gate leakage current. Thanks to this result, heterostructures have been optimized to minimize the gate leakage current and the low frequency noise. During this thesis, specific methods have been developed to measure very low-gate-leakage-current values, transistor’s capacitances and the 1/f noise with a very high input impedance. Two experimental relationships have been observed, one for the 1/f noise and other for the white noise in these HEMTs at 4.2 K. Significant advances have been made, for information, the HEMTs with a gate capacitance of 92 pF and a consumption of 100 µW can reach a noise voltage of 6.3 nV/√ Hz at 1 Hz, a white noise voltage of 0.2 nV/√ Hz, and a noise current of 50 aA/√Hz at 10 Hz. Finally, a series of 400 HEMTs has been realized which fully meet the specifications required for realizing preamplifiers at CEA/IRFU. The results of this thesis will provide a solid base for a better understanding of 1/f noise and white noise in cryogenic HEMTs with the objective to improve them for various considered applications
Ay, Aysecan. "Resistance In Everyday Life: Coping With The Smoking Ban In The Case Of Nevizade." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612788/index.pdf.
Повний текст джерелаHirsekorn, Hauke. "Bag-1- und bcl-2-Protoonkogene in normalen und neoplastischen Strukturen der Prostata immunhistochemische Untersuchungen /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975199102.
Повний текст джерелаMotamedi, Mina. "Characterization of anti-apoptotic protein family members (Bax inhibitor-1 and Lifeguard) in Hydra vulgaris." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-160446.
Повний текст джерелаCrocoll, Alexander [Verfasser]. "Expression und antiapoptotische Funktion des Bag-1 Proteins während der Embryonalentwicklung der Maus / Alexander Crocoll." Karlsruhe : KIT-Bibliothek, 2001. http://d-nb.info/1198221933/34.
Повний текст джерелаTukwayo, Philiswa P. "Temporal and spatial variability in a copepod community off St Helena Bay in 2000/1." Master's thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/6204.
Повний текст джерелаThe driving forces behind changes in copepod community structure in the Benguela upwelling region are examined. For this study, monthly changes in copepod size structure and species composition were examined at St Helena Bay in 2000/1 in relation to upwelling, phytoplankton and fish. The copepod assemblage was dominated by large species categories in the early period of recruitment (April) and smaller species categories in the late period of recruitment (August). The reappearance of large species categories and increase in copepod biomass is observed in summer months. This is attributed to both predation and upwelling intensity. Arguments are developed to suggest that the copepod size. structure is consistent with 'wasp-waist' control and 'bottom-up' control was responsible for the copepod increase.
Oliveira, Luiza Monteiro de Barros. "Os Caminhos do mal – uma análise semiótica de Breaking Bad." Niterói, 2017. https://app.uff.br/riuff/handle/1/3418.
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A presente dissertação de mestrado propõe-se a analisar, por meio do aparato da semiótica francesa, a série de televisão Breaking bad, transmitida entre 2008 e 2013 pelo canal norte-americano AMC. Parte da chamada nova “era de ouro” da televisão americana, a série criada por Vince Gilligan apresenta uma narrativa inventiva que conquistou tanto público quanto crítica, sobretudo pelo apelo de seu protagonista, Walter White. A partir do percurso gerativo de sentido de Algirdas Greimas, a análise concentrase nos níveis narrativos e discursivos para acompanhar quais estratégias são empregadas nesta obra audiovisual. Em especial, propomos um estudo sobre as paixões do protagonista e os valores que são postos em jogo por meio da articulação entre recursos verbais e visuais
This work uses french semiotics to analyse the TV series Breaking bad, transmited between 2008 and 2013 on AMC channel in the United States. Identified as part of the so called new american TV “Golden age”, the series created by Vince Gilligan features an inventive narrative that was equally accepted by the audience and TV critics, with its protagonist, Walter White, as the greatest cause of its success. In this work, the narrative and discoursive levels of Algirdas Greimas’ generative meaning trajectory are used to follow which strategies are used in this audiovisual work. In special, we propose a study about the protagonist’s passions and the values that are displayed through the articulation between verbal and visual recourses
Leddin, Mathias. "Unterschiedliche Autoregulation am PU.1 Lokus in B -Zellen und myeloischen Zellen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16546.
Повний текст джерелаThe transcription factor PU.1 occupies a central role in controlling myeloid and early B cell development and its correct lineage-specific expression is critical for the differentiation choice of hematopoietic progenitors. However, little is known of how this tissue-specific pattern is established. We previously identified an upstream regulatory cis-element (URE) whose targeted deletion in mice decreases PU.1 expression and causes leukemia. We show here that the URE alone is insufficient to confer physiological PU.1 expression, but requires the cooperation with other, previously unidentified elements. Using a combination of transgenic studies, global chromatin assays and detailed molecular analyses we present evidence that PU.1 is regulated by a novel mechanism involving cross-talk between different cis-elements together with lineage-restricted autoregulation. In this model, PU.1 regulates its expression in B cells and macrophages by differentially associating with cell-type specific transcription factors at one of its cis-regulatory elements to establish differential activity patterns at other elements.