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Статті в журналах з теми "BAF47"

Автор: Grafiati

Опубліковано: 21 грудня 2024

Оновлено: 31 липня 2025

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1

Arafah, Maria A., and Muna I. Aljuboury. "Primary Vulval Rhabdoid Tumor in an Adult: A Case Report, Immunohistochemical Profile and Literature Review." Case Reports in Medicine 2011 (2011): 1–4. http://dx.doi.org/10.1155/2011/162709.

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We report a rare case of primary vulval rhabdoid tumor in an adult. The diagnosis was confirmed using the recently emerging INI1/BAF47 immunostain. We also demonstrate the expression of ER and PR hormonal receptors by the tumor cells.

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2

Yan, Li, Si Xie, Yongming Du, and Chengmin Qian. "Structural Insights into BAF47 and BAF155 Complex Formation." Journal of Molecular Biology 429, no. 11 (2017): 1650–60. http://dx.doi.org/10.1016/j.jmb.2017.04.008.

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3

Harada, Akihito, Masayasu Hayashi, Yuuki Kuniyoshi, et al. "Generation of a Monoclonal Antibody for INI1/hSNF5/BAF47." Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 33, no. 1 (2014): 49–51. http://dx.doi.org/10.1089/mab.2013.0065.

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4

Cui, Kairong, Prafullakumar Tailor, Hong Liu, Xin Chen, Keiko Ozato, and Keji Zhao. "The Chromatin-Remodeling BAF Complex Mediates Cellular Antiviral Activities by Promoter Priming." Molecular and Cellular Biology 24, no. 10 (2004): 4476–86. http://dx.doi.org/10.1128/mcb.24.10.4476-4486.2004.

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ABSTRACT The elicitation of cellular antiviral activities is dependent on the rapid transcriptional activation of interferon (IFN) target genes. It is not clear how the interferon target promoters, which are organized into chromatin structures in cells, rapidly respond to interferon or viral stimulation. In this report, we show that alpha IFN (IFN-α) treatment of HeLa cells induced hundreds of genes. The induction of the majority of these genes was inhibited when one critical subunit of the chromatin-remodeling SWI/SNF-like BAF complexes, BAF47, was knocked down via RNA interference. Inhibitio

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5

Kimura, Noriko, Masaru Hasegawa, and Kenzo Hiroshima. "SMARCB1/INI1/BAF47- deficient pleural malignant mesothelioma with rhabdoid features." Pathology International 68, no. 2 (2018): 128–32. http://dx.doi.org/10.1111/pin.12623.

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6

Numata, Masakatsu, Soichiro Morinaga, Takuo Watanabe, et al. "The clinical significance of SWI/SNF complex in pancreatic cancer." Journal of Clinical Oncology 31, no. 4_suppl (2013): 149. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.149.

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149 Background: Chromatin remodeling factors have been the subject of great interest in oncology. However, little is known about their role in pancreatic cancer. The objective of this study is to clarify the clinical significance of SWI/SNF complex, one of the major chromatin remodeling machineries, in patients with pancreatic cancer. Methods: 68 cases with pancreatic cancer who underwent R0, 1 resection were enrolled. Cancer tissues were processed to tissue microarray, then stained immunohistochemically by using antibody of SWI/SNF components; BRM, BRG1, BAF250a, BAF180, and BAF47. The correl

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7

Hoffman, Lindsey M., Elizabeth Anne Richardson, Ben Ho, et al. "Advancing biology-based therapeutic approaches for atypical teratoid rhabdoid tumors." Neuro-Oncology 22, no. 7 (2020): 944–54. http://dx.doi.org/10.1093/neuonc/noaa046.

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Abstract Atypical teratoid rhabdoid tumor (ATRT) is a rare, highly malignant central nervous system cancer arising in infants and younger children, historically considered to be homogeneous, monogenic, and incurable. Recent use of intensified therapies has modestly improved survival for ATRT; however, a majority of patients will still succumb to their disease. While ATRTs almost universally exhibit loss of SMARCB1 (BAF47/INI1/SNF5), recent whole genome, transcriptome, and epigenomic analyses of large cohorts reveal previously underappreciated molecular heterogeneity. These discoveries provide

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8

Pan, Xuefang, Lei Zhai, Ru Sun, Xiaoyun Li, and Xianlu Zeng. "INI1/hSNF5/BAF47 represses c-fos transcription via a histone deacetylase-dependent manner." Biochemical and Biophysical Research Communications 337, no. 4 (2005): 1052–58. http://dx.doi.org/10.1016/j.bbrc.2005.09.155.

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9

McLendon, Roger E., Adesina Adekunle, Veena Rajaram, Mehmet Koçak, and Susan M. Blaney. "Embryonal Central Nervous System Neoplasms Arising in Infants and Young Children: A Pediatric Brain Tumor Consortium Study." Archives of Pathology & Laboratory Medicine 135, no. 8 (2011): 984–93. http://dx.doi.org/10.5858/2010-0515-oar1.

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Context.—Medulloblastomas (MBs) and atypical teratoid/rhabdoid tumors (AT/RTs) arising in infants and children can be difficult to distinguish; however, histologic characterization is prognostically important. Objective.—To determine histologic and phenotypic markers associated with utility with progression-free survival (PFS) and overall survival (OS) in children younger than 3 years with MBs and AT/RTs. Design.—We undertook a histologic and immunophenotypic study of MBs and AT/RTs arising in infants and children younger than 3 years treated in a Pediatric Brain Tumor Consortium study. The 41

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10

Rekhi, Bharat, and Ulrich Vogel. "Utility of characteristic ‘Weak to Absent’ INI1/SMARCB1/BAF47 expression in diagnosis of synovial sarcomas." APMIS 123, no. 7 (2015): 618–28. http://dx.doi.org/10.1111/apm.12395.

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11

Rekhi, Bharat, and Ulrich Vogel. "Value of characteristic ‘weak to absent’ INI1/SMARCB1/BAF47 expression in diagnosis of synovial sarcomas." Pathology 48 (February 2016): S152. http://dx.doi.org/10.1016/j.pathol.2015.12.415.

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12

Ye, Youpi, Hao Wu, Kangjing Chen, et al. "Structure of the RSC complex bound to the nucleosome." Science 366, no. 6467 (2019): 838–43. http://dx.doi.org/10.1126/science.aay0033.

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The RSC complex remodels chromatin structure and regulates gene transcription. We used cryo–electron microscopy to determine the structure of yeast RSC bound to the nucleosome. RSC is delineated into the adenosine triphosphatase motor, the actin-related protein module, and the substrate recruitment module (SRM). RSC binds the nucleosome mainly through the motor, with the auxiliary subunit Sfh1 engaging the H2A-H2B acidic patch to enable nucleosome ejection. SRM is organized into three substrate-binding lobes poised to bind their respective nucleosomal epitopes. The relative orientations of the

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13

Stevens, E. Andrew, Constance A. Stanton, Kyle Nichols, and Thomas L. Ellis. "Rare intraparenchymal choroid plexus carcinoma resembling atypical teratoid/rhabdoid tumor diagnosed by immunostaining for INI1 protein." Journal of Neurosurgery: Pediatrics 4, no. 4 (2009): 368–71. http://dx.doi.org/10.3171/2009.5.peds0955.

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The authors present the case of a rare extraventricular, intraparenchymal choroid plexus carcinoma (CPC). This 6-year-old girl presented to the emergency department with a 1-week history of headaches, nausea, and vomiting. Imaging studies revealed an intraaxial cystic and solid mass located in the right frontal lobe with central nodular enhancement and minimally enhancing cyst walls. Gross-total resection was accomplished via craniotomy without complications. The initial pathological diagnosis was atypical teratoid/rhabdoid tumor (AT/RT); however, immunostaining for INI1 protein (using the BAF

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14

DeCristofaro, Marc F., Bryan L. Betz, Weidong Wang, and Bernard E. Weissman. "Alteration of hSNF5/INI1/BAF47 detected in rhabdoid cell lines and primary rhabdomyosarcomas but not Wilms' tumors." Oncogene 18, no. 52 (1999): 7559–65. http://dx.doi.org/10.1038/sj.onc.1203168.

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15

Pan, Xuefang, Zhaoxia Song, Lei Zhai, Xiaoyun Li, and Xianlu Zeng. "Chromatin-remodeling Factor INI1/hSNF5/BAF47 Is Involved in Activation of the Colony Stimulating Factor 1 Promoter." Molecules and Cells 20, no. 2 (2005): 183–88. http://dx.doi.org/10.1016/s1016-8478(23)25244-9.

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16

Edgar, Mark A., and Marc K. Rosenblum. "The Differential Diagnosis of Central Nervous System Tumors: A Critical Examination of Some Recent Immunohistochemical Applications." Archives of Pathology & Laboratory Medicine 132, no. 3 (2008): 500–509. http://dx.doi.org/10.5858/2008-132-500-tddocn.

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Abstract Context.—As we write, novel antibodies that may well alter the routine practice of surgical neuropathology are in development, characterization, and the early stages of clinical use. These will be used for purposes of tumor subclassification, as prognostic markers, as identifiers of potential therapeutic targets, and as predictors of treatment response. Objective.—To provide for nonspecialists a critical assessment of the peer-reviewed literature (necessarily colored by our own experience) as it pertains to several immunohistochemical reagents that have been recently forwarded as adju

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17

Ohba, Shigeo, Kazunari Yoshida, Yuichi Hirose, Eiji Ikeda, Yoichi Nakazato, and Takeshi Kawase. "Cerebral tumor with extensive rhabdoid features and a favorable prognosis." Journal of Neurosurgery 111, no. 3 (2009): 492–96. http://dx.doi.org/10.3171/2008.11.jns08776.

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This 32-year-old woman, 27 weeks pregnant, harbored a cystic mass with a solid component in the left frontal lobe. Histologically, the lesion was hypercellular and contained a diffuse sheet of eosinophilic cells of various sizes. The cells were almost round and had a few prominent, eccentrically placed, hyperchromatic nuclei of various sizes. Immunohistochemically, the tumor was reactive for vimentin, epithelial membrane antigen, cytokeratin AE1/AE3, smooth muscle actin, and BAF47/INI-1, and negative for glial fibrillary acidic protein, neurofilament protein, S100 protein, CK7, CK20, HMB-45, M

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18

Joliot, Véronique, Ouardia Ait-Mohamed, Valentine Battisti, et al. "The SWI/SNF Subunit/Tumor Suppressor BAF47/INI1 Is Essential in Cell Cycle Arrest upon Skeletal Muscle Terminal Differentiation." PLoS ONE 9, no. 10 (2014): e108858. http://dx.doi.org/10.1371/journal.pone.0108858.

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19

Bourgo, Ryan J., Hasan Siddiqui, Sejal Fox, et al. "SWI/SNF Deficiency Results in Aberrant Chromatin Organization, Mitotic Failure, and Diminished Proliferative Capacity." Molecular Biology of the Cell 20, no. 14 (2009): 3192–99. http://dx.doi.org/10.1091/mbc.e08-12-1224.

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Switch (SWI)/sucrose nonfermentable (SNF) is an evolutionarily conserved complex with ATPase function, capable of regulating nucleosome position to alter transcriptional programs within the cell. It is known that the SWI/SNF complex is responsible for regulation of many genes involved in cell cycle control and proliferation, and it has recently been implicated in cancer development. The ATPase action of SWI/SNF is conferred through either the brahma-related gene 1 (Brg1) or brahma (Brm) subunit of the complex, and it is of central importance to the modification of nucleosome position. In this

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20

Sarkar, Koustav, Sanjoy Sadhukhan, Seong-Su Han, and Yatin Vyas. "Nucleosomal remodeling defects at gene promoters underlie cross-phenotype effects in X-linked thrombocytopenia/Wiskott-Aldrich syndrome (IRM6P.655)." Journal of Immunology 194, no. 1_Supplement (2015): 60.5. http://dx.doi.org/10.4049/jimmunol.194.supp.60.5.

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Abstract Loss-of-function mutations in Wiskott-Aldrich-Syndrome (WAS) gene associate with either X-linked thrombocytopenia (XLT) or XLT that progresses to immunodeficiency, yet the biological basis for gene-pleiotropy remains unknown. WASp, the protein deficient in WAS, generates F-actin in the cytosol via VCA-domain and supports transcription in the nucleus, the latter by an unknown mechanism. We report that nuclear-WASp, independently of its VCA-domain, is required for the recruitment of BAF47, BAF170, and EP400 to IFNG and TBX21 promoters during TH1-differentiation, but not to IL4 or GATA3

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21

Andreeva, N. A., E. I. Lyudovskikh, D. M. Konovalov, et al. "SMARCA4-associated malignant rhabdoid tumors: case report and literature review." Russian Journal of Pediatric Hematology and Oncology 9, no. 2 (2022): 75–84. http://dx.doi.org/10.21682/2311-1267-2022-9-2-75-84.

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Malignant rhabdoid tumor (MRT) is a rare malignant neoplasm of childhood, characterized by an aggressive course and an extremely unfavorable prognosis. The frequency of MRT outside the central nervous system (extracranial MRT) is 0.02–0.03 per 100,000 children. In most cases, MRT is based on an inactivating mutations of the tumor suppressor gene SMARCB1, which leads to the absence of expression of the SMARCB1 ((INI1/hSNF5/BAF47) protein in tumor cells. Aberrations of the SMARCA4 gene, which is an extremely rare molecular event, have been described among the MRTs expressing SMARCB1 (INI1). Few

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22

McKenna, Elizabeth S., Courtney G. Sansam, Yoon-Jae Cho, et al. "Loss of the Epigenetic Tumor Suppressor SNF5 Leads to Cancer without Genomic Instability." Molecular and Cellular Biology 28, no. 20 (2008): 6223–33. http://dx.doi.org/10.1128/mcb.00658-08.

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ABSTRACT There is a growing appreciation of the role that epigenetic alterations can play in oncogenesis. However, given the large number of genetic anomalies present in most cancers, it has been difficult to evaluate the extent to which epigenetic changes contribute to cancer. SNF5 (INI1/SMARCB1/BAF47) is a tumor suppressor that regulates the epigenome as a core member of the SWI/SNF chromatin remodeling complex. While the SWI/SNF complex displays potent tumor suppressor activity, it is unknown whether this activity is exerted genetically via maintenance of genome integrity or epigenetically

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23

Betz, Bryan L., Matthew W. Strobeck, David N. Reisman, Erik S. Knudsen, and Bernard E. Weissman. "Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1arrest associated with induction of p16ink4a and activation of RB." Oncogene 21, no. 34 (2002): 5193–203. http://dx.doi.org/10.1038/sj.onc.1205706.

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24

Boese, Annette, Peter Sommer, Daniela Holzer, Reinhard Maier, and Ulf Nehrbass. "Integrase interactor 1 (Ini1/hSNF5) is a repressor of basal human immunodeficiency virus type 1 promoter activity." Journal of General Virology 90, no. 10 (2009): 2503–12. http://dx.doi.org/10.1099/vir.0.013656-0.

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Integrase interactor 1 (Ini1/hSNF5/BAF47/SMARCB1), the core subunit of the ATP-dependent chromatin-remodelling complex SWI/SNF, is a cellular interaction partner of the human immunodeficiency virus type 1 (HIV-1) integrase. Ini1/hSNF5 is recruited to HIV-1 pre-integration complexes before nuclear migration, suggesting a function in the integration process itself or a contribution to the preferential selection of transcriptionally active genes as integration sites of HIV-1. More recent evidence indicates, however, that, whilst Ini1/hSNF5 is dispensable for HIV-1 transduction per se, it may have

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25

Roberts, Charles W. M. "Abstract IA006: Synthetic lethalities for SWI/SNF mutant cancers." Molecular Cancer Therapeutics 23, no. 6_Supplement (2024): IA006. http://dx.doi.org/10.1158/1538-8514.synthleth24-ia006.

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Abstract Genes that encode subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in over 20% of cancers. These include recurrent mutations of ARID1A (BAF250a) in ovarian, endometrioid, bladder, stomach, colorectal and pancreatic cancers and neuroblastoma; of the SMARCA4 (BRG1) subunit in medulloblastomas and non-small cell lung cancers; of the PBRM1 subunit in renal carcinomas; of the ARID2 subunit in hepatocellular, lung, and pancreas carcinomas as well as melanomas; of the BRD7 subunit in breast cancers. The SWI/SNF complex includes both core and lineage-specific subunits and

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26

Link, Kevin A., Craig J. Burd, Erin Williams, et al. "BAF57 Governs Androgen Receptor Action and Androgen-Dependent Proliferation through SWI/SNF." Molecular and Cellular Biology 25, no. 6 (2005): 2200–2215. http://dx.doi.org/10.1128/mcb.25.6.2200-2215.2005.

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ABSTRACT Androgen receptor (AR) activity is required for prostate cancer development and progression. Thus, there is a major impetus to understand the regulation of AR action. We and others have previously shown that AR transactivation potential is dependent on the presence of an active SWI/SNF chromatin remodeling complex. However, the mechanisms underlying SWI/SNF regulation of the AR remained unsolved. We show here that the BAF57 subunit, an accessory component of the remodeling complex, is a critical regulator of AR function. We show that BAF57 is expressed in the luminal epithelia of the

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27

Pawel, Bruce R. "SMARCB1-deficient Tumors of Childhood: A Practical Guide." Pediatric and Developmental Pathology 21, no. 1 (2017): 6–28. http://dx.doi.org/10.1177/1093526617749671.

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The SMARCB1 gene ( INI1, BAF47) is a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex, involved in the epigenetic regulation of gene transcription. SMARCB1 acts as a tumor suppressor gene, and loss of function of both alleles gives rise to SMARCB1-deficient tumors. The prototypical SMARCB1-deficient tumor is the malignant rhabdoid tumor (MRT) which was first described in the kidney but also occurs in soft tissue, viscera, and the brain (where it is referred to as atypical teratoid rhabdoid tumor or AT/RT). These are overwhelmingly tumors of the very young, an

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28

Kadoch, Cigall, and Gerald R. Crabtree. "Reversing the oncogenic roles of misdirected chromatin remodeling: Mechanistic insights into the SS18-SSX fusion protein in synovial sarcoma." Journal of Clinical Oncology 31, no. 15_suppl (2013): 10515. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.10515.

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10515 Background: Synovial sarcoma (SS) accounts for ~10% of soft-tissue malignancies and is generally resistant to chemotherapy-based approaches, underscoring the need for a mechanistic understanding of its pathogenesis and the development of disease-specific biologic agents. The hallmark molecular feature is a precise and uniform translocation, t(X;18), which results in the fusion of exactly 78 amino acids of SSX to the SS18 C-terminus. Because the SS18-SSX genetic lesion is observed in 100% of cases, it is likely the driving oncogenic event in these tumors; however, the molecular basis for

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29

Patel, Krutika, Sara Avalos Hernandez, S. Shawn Liu, J. Elliot Carter, and Elizabeth Manci. "Tubular Entrapment May Be Inconspicuous in Clear Cell Sarcoma of the Kidney in Early Infancy, Compared to Childhood: An In-Depth Case Comparison." American Journal of Clinical Pathology 152, Supplement_1 (2019): S59—S60. http://dx.doi.org/10.1093/ajcp/aqz113.056.

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Abstract Introduction Clear cell sarcoma of kidney (CCSK) is a rare malignancy accounting for <0.5% of all primary renal tumors, commonly diagnosed between 2 and 4 years of age and rarely occurring in early infancy. The challenging differentiation between CCSK and blastemal Wilms tumor is important because of the distinct clinical pattern of CCSK to recur and metastasize to bone and brain. The aim of this study is to discern subtle features that could assist pathologists in diagnosing CCSK in infancy. Method In-depth comparison of clinical, histological, and immunohistochemical findings in

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30

Wang, Li, Robert A. Baiocchi, Sharmistha Pal, George Mosialos, Michael Caligiuri, and Saïd Sif. "The BRG1- and hBRM-Associated Factor BAF57 Induces Apoptosis by Stimulating Expression of the Cylindromatosis Tumor Suppressor Gene." Molecular and Cellular Biology 25, no. 18 (2005): 7953–65. http://dx.doi.org/10.1128/mcb.25.18.7953-7965.2005.

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ABSTRACT Mutation of BRG1, hBRM, and their associated factors, INI1 and BAF57, in primary human tumors has suggested that inactivation of human SWI/SNF (hSWI/SNF) complexes may be involved in neoplastic transformation. BT549 is an invasive human breast carcinoma cell line that lacks expression of BAF57, a key hSWI/SNF subunit that mediates interaction with transcriptional activators and corepressors. In this study we investigated the role of BAF57 in suppressing tumorigenesis by establishing BT549 stable cell lines that expresses full-length BAF57 protein. BT549 clones expressing BAF57 demonst

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31

Msaouel, Pavlos, Rebecca Slack-Tidwell, and Nizar M. Tannir. "Phase II trial of nivolumab (nivo) plus ipilimumab (ipi) in patients with SMARCB1-deficient kidney malignancies." Journal of Clinical Oncology 37, no. 7_suppl (2019): TPS677. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.tps677.

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TPS677 Background: The potent tumor suppressor SMARCB1 (also known as INI-1, hSNF5, or BAF47) is inactivated in all cases of renal medullary carcinoma (RMC) and renal cell carcinoma unclassified with medullary phenotype (RCCU-MP), as well as most malignant rhabdoid tumors (MRT) of the kidney. Although rare, these kidney malignancies are highly lethal and often occur in young patients. The role of immune checkpoint inhibitor therapy remains to be prospectively defined in tumors harboring SMARCB1 defects. Although a case report noted efficacy of single-agent Nivo in a patient with RMC (Beckerman

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32

Msaouel, Pavlos, Rebecca Slack-Tidwell, Giannicola Genovese, Najat C. Daw, Arlene O. Siefker-Radtke, and Nizar M. Tannir. "Phase II trial of ixazomib combined with gemcitabine and doxorubicin in patients with SMARCB1-deficient kidney malignancies." Journal of Clinical Oncology 37, no. 7_suppl (2019): TPS678. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.tps678.

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TPS678 Background: SMARCB1 (also known as INI-1, hSNF5, or BAF47) is a potent tumor suppressor inactivated in all cases of renal medullary carcinoma (RMC) and renal cell carcinoma unclassified with medullary phenotype (RCCU-MP), as well as the majority of malignant rhabdoid tumors (MRT). These highly aggressive malignancies often occur in young patients (pts) and are associated with poor prognosis. There are currently no approved therapies targeting SMARCB1 defects. We previously showed that SMARCB1 loss induces a synthetically lethal vulnerability to perturbations of the cellular proteostasis

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33

Chen, Jianguang, and Trevor K. Archer. "Regulating SWI/SNF Subunit Levels via Protein-Protein Interactions and Proteasomal Degradation: BAF155 and BAF170 Limit Expression of BAF57." Molecular and Cellular Biology 25, no. 20 (2005): 9016–27. http://dx.doi.org/10.1128/mcb.25.20.9016-9027.2005.

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ABSTRACT The mammalian SWI/SNF chromatin remodeling complex, whose function is of critical importance in transcriptional regulation, contains approximately 10 protein components. The expression levels of the core SWI/SNF subunits, including BRG1/Brm, BAF155, BAF170, BAF60, hSNF/Ini1, and BAF57, are stoichiometric, with few to no unbound molecules in the cell. Here we report that exogenous expression of the wild type or certain deletion mutants of BAF57, a key subunit that mediates the interaction between the remodeling complex and transcription factors, results in diminished expression of endo

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34

Liu, J., S. Yeon, T. Valyi-Nagy, and S. Garzon. "Uncommon Presentation of Pulmonary Adenoid Cystic Carcinoma: A Case of Brain Metastasis in a Young Smoker." American Journal of Clinical Pathology 162, Supplement_1 (2024): S140. http://dx.doi.org/10.1093/ajcp/aqae129.310.

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Abstract Introduction/Objective Pulmonary adenoid cystic carcinoma (PACC) is a rare entity, accounting for only 0.04-0.2% lung cancers, and mainly originating from the small salivary glands in the tracheobronchial tree. Due to slow-growing pattern and unspecific symptoms, the diagnosis is often delayed. While metastasis in PACC is uncommon, reports of brain metastasis are exceedingly rare. We present a case of PACC with metastasis to the brain in a young smoker. Methods/Case Report A 29-year-old female with history of smoking presented with headache, hypersomnia, episodes of vomiting and falli

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Feng, Jianguo, Xichao Xu, Xin Fan, Qian Yi, and Liling Tang. "BAF57/SMARCE1 Interacting with Splicing Factor SRSF1 Regulates Mechanical Stress-Induced Alternative Splicing of Cyclin D1." Genes 12, no. 2 (2021): 306. http://dx.doi.org/10.3390/genes12020306.

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Background: Cyclin D1 regulates cyclin-dependent protein kinase activity of the cell cycle, and cyclin D1 alternative splicing generates a cyclin D1b isoform, acting as a mediator of aberrant cellular proliferation. As alternative splicing processes are sensitive to mechanical stimuli, whether the alternative splicing of cyclin D1 is regulated by mechanical stress and what kinds of factors may act as the regulator of mechano-induced alternative splicing remain unknown. Methods: The alternative splicing of Cyclin D1 was examined using reverse transcription polymerase chain reaction (RT-PCR) in

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La Porte, Annalena, Jennifer Cano, Xuhong Wu, Doyel Mitra, and Ganjam V. Kalpana. "An Essential Role of INI1/hSNF5 Chromatin Remodeling Protein in HIV-1 Posttranscriptional Events and Gag/Gag-Pol Stability." Journal of Virology 90, no. 21 (2016): 9889–904. http://dx.doi.org/10.1128/jvi.00323-16.

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ABSTRACTINI1/hSNF5/SMARCB1/BAF47 is an HIV-specific integrase (IN)-binding protein that influences HIV-1 transcription and particle production. INI1 binds to SAP18 (Sin3a-associated protein, 18 kDa), and both INI1 and SAP18 are incorporated into HIV-1 virions. To determine the significance of INI1 and the INI1-SAP18 interaction during HIV-1 replication, we isolated a panel ofSAP18-interaction-defective (SID)-INI1 mutants using a yeast reverse two-hybrid screen. The SID-INI1 mutants, which retained the ability to bind to IN, cMYC, and INI1 but were impaired for binding to SAP18, were tested for

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Balasubramaniam, Sucharitha, Clay E. S. Comstock, Adam Ertel, et al. "Aberrant BAF57 Signaling Facilitates Prometastatic Phenotypes." Clinical Cancer Research 19, no. 10 (2013): 2657–67. http://dx.doi.org/10.1158/1078-0432.ccr-12-3049.

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Moon, Jae-Seung, Hong-Jai Lee, Chun-Chang Ho та ін. "Immuno-suppressive function of nucleus-transducible BAF57-ΔPH in T cell activation via degradation of endogenous BAF57". International Journal of Hematology 108, № 4 (2018): 375–83. http://dx.doi.org/10.1007/s12185-018-2491-6.

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Wooff, David A. "Bayes Linear Sufficiency in Non-exchangeable Multivariate Multiple Regressions." Bayesian Analysis 9, no. 1 (2014): 77–96. http://dx.doi.org/10.1214/13-ba847.

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Carbonari, Luan Tiago dos Santos, Rita Carolina de Melo, Paulo Henrique Cerutti, Altamir Frederico Guidolin, and Jefferson Luís Meirelles Coimbra. "Análise multivariada aplicada na discriminação de genótipos em caracteres do tempo de cozimento em feijão (Phaseolus vulgaris L.)." Revista de Ciências Agroveterinárias 22, no. 3 (2023): 358–66. http://dx.doi.org/10.5965/223811712232023358.

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As avaliações rotineiras do caráter tempo de cozimento em feijão (Phaseolus vulgaris L.) podem ser efetuadas de distintas maneiras resultando em diferentes variáveis. Por vez, a análise estatística univariada não considera as interdependêcias entre as variáveis, podendo omitir importantes informações a respeito dos genótipos. Com isso, o objetivo do trabalho foi dispor uma proposta alternativa para análise do tempo de cozimento em feijão, permitindo a discriminação entre genótipos. O experimento utilizado para esta abordagem foi conduzido em condições de campo na safra agrícola do ano 2017/18

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SUZUMURA, HIROFUMI, MASASHI TSURUTA, KOJI OKABAYASHI, et al. "BAF57 Is a Potential Determinant of Colorectal Cancer Malignancy." Anticancer Research 41, no. 11 (2021): 5445–52. http://dx.doi.org/10.21873/anticanres.15356.

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Domingos, Pedro M., Tetyana V. Obukhanych, Curtis R. Altmann, and A. Hemmati-Brivanlou. "Cloning and developmental expression of Baf57 in Xenopus laevis." Mechanisms of Development 116, no. 1-2 (2002): 177–81. http://dx.doi.org/10.1016/s0925-4773(02)00129-6.

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Witzel, Maximilian, Daniel Petersheim, Yanxin Fan, et al. "SWI/SNF Protein SMARCD2 Orchestrates Transcriptional Networks Controlling Hematopoiesis and Neutrophil Granulocytes in Humans, Mice and Zebrafish." Blood 128, no. 22 (2016): 2. http://dx.doi.org/10.1182/blood.v128.22.2.2.

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Abstract Differentiation of hematopoietic stem cells follows a hierarchical program of transcriptional-regulated events. We here identify SMARCD2 (Swi/Snf-related matrix associated actin dependent regulator of chromatin, subfamily D, member 2) as critical regulator of myelopoiesis in humans, mice, and zebrafish. We studied four patients from three unrelated pedigrees presenting with a novel syndromatic phenotype comprising congenital neutropenia, specific granule deficiency, susceptibility to myelodysplasia with excess of blasts, and various skeletal anomalies. All patients had homozygous loss

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Joaquim Júnior, Carlos Zacarias, Paulo Henrique Cerutti, Luan Tiago dos Santos Carbonari, et al. "Seleção de genótipos de feijão com potencial uso no melhoramento de novas cultivares tolerantes ao S-metolachlor." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 22, no. 4 (2024): e4263. http://dx.doi.org/10.55905/oelv22n4-153.

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O feijão é uma das leguminosas mais importantes para o consumo humano e um alimento básico para milhões de pessoas em todo o mundo, devido ao seu alto valor nutricional como proteína, minerais, antioxidantes e compostos bioativos. Entretanto, vários fatores são limitantes na produtividade desta cultura, sendo um deles a interferência que é causada pelas plantas daninhas. Por isso, o uso de herbicidas vem sendo uma alternativa para o controle destas espécies no cultivo. A utilização do S-metolachlor para controle de plantas daninhas, exige que a cultura seja tolerante a este herbicida, o que as

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Dye, Collin, Sean Keenan, Brandon M. Carius, et al. "Airway Management in Prolonged Field Care." Journal of Special Operations Medicine 20, no. 3 (2020): 141. http://dx.doi.org/10.55460/baf7-3bm3.

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Yamaguchi, Takahiro, Tomoko Kurita, Kazuto Nishio, et al. "Expression of BAF57 in ovarian cancer cells and drug sensitivity." Cancer Science 106, no. 4 (2015): 359–66. http://dx.doi.org/10.1111/cas.12612.

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Kiskinis, Evangelos, Juana M. García-Pedrero, M. Angeles Villaronga, Malcolm G. Parker, and Borja Belandia. "Identification of BAF57 mutations in human breast cancer cell lines." Breast Cancer Research and Treatment 98, no. 2 (2006): 191–98. http://dx.doi.org/10.1007/s10549-005-9149-9.

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Yeh, Jeng-Hsien. "Effect of Thymol on Ca^(2+) Homeostasis and Viability in PC3 Human Prostate Cancer Cells." Chinese Journal of Physiology 60, no. 1 (2017): 32–40. http://dx.doi.org/10.4077/cjp.2017.baf447.

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Stjepanovic, Mirko. "Swimming Three Ice Miles within Fifteen Hours." Chinese Journal of Physiology 60, no. 4 (2017): 197–206. http://dx.doi.org/10.4077/cjp.2017.baf467.

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Huang, Wen-Ching. "The Modulative Effects of Microcurrent Electrical Nerve Stimulation on Diabetic Mice." Chinese Journal of Physiology 60, no. 1 (2017): 62–72. http://dx.doi.org/10.4077/cjp.2017.baf476.

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