Дисертації з теми "Bacterial metabolism and pathogenesis"
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Haque, Md Risat Ul. "Bacterial nitric oxide metabolism in the pathogenesis of meningococcal sepsis." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/12201/.
Повний текст джерелаCordes, Frank Stephan. "Biophysical studies of bacterial pathogenesis." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404113.
Повний текст джерелаBorodina, Elena. "Bacterial metabolism of dimethylsulfone." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251998.
Повний текст джерелаGreen, Luke Richard. "The role of teraspanins in bacterial pathogenesis." Thesis, University of Sheffield, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522436.
Повний текст джерелаKaittanis, Charalambos. "Magnetic nanosensors for multiplexed bacterial pathogenesis identification." Doctoral diss., University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4610.
Повний текст джерелаID: 028916614; System requirements: World Wide Web browser and PDF reader.; Mode of access: World Wide Web.; Thesis (Ph.D.)--University of Central Florida, 2010.; Includes bibliographical references (p. 139-150).
Ph.D.
Doctorate
Burnett School of Biomedical Sciences
Medicine
Vdovikova, Svitlana. "Roles of membrane vesicles in bacterial pathogenesis." Doctoral thesis, Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138714.
Повний текст джерелаWoods, Nigel R. "The bacterial metabolism of propane." Thesis, University of Warwick, 1988. http://wrap.warwick.ac.uk/98056/.
Повний текст джерелаErdlenbruch, Barbara Nicole Susanne. "Bacterial metabolism of short chain alkanesulfonates." Thesis, University of Warwick, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250990.
Повний текст джерелаde, Klerk Nele. "Host-bacteria interactions : Host cell responses and bacterial pathogenesis." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-126425.
Повний текст джерелаAt the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Manuscript. Paper 4: Manuscript.
Gonçalves, Carla Aguiar. "The role of polyunsaturated fatty acids in bacterial pathogenesis." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13794.
Повний текст джерелаPolyunsaturated fatty acids (PUFAs) comprise a class of essential micronutrients, which are essential for normal development, cardiovascular health, and immunity. The role of lipids, including long-chain fatty acids, in the immune response is increasingly being recognized as beneficial regulators of the immune systems. However, the mechanisms by which PUFAs modulate innate immunity are yet to be fully clarified. C. elegans has been used in several recent studies as a simple animal model for the study of host-pathogen interactions, generating important insights into both bacterial pathogenesis and host innate immunity. Many of the virulence mechanisms used by bacterial pathogens to cause disease in mammalian hosts have also been shown to be important for pathogenesis in C. elegans and, similarly, important features of the host innate immunity have been evolutionarily conserved between C. elegans and mammals. This project is focused on addressing the role of polyunsaturated fatty acids in bacterial pathogenesis using C. elegans as model system. We find that knockdown of some elongase genes increase the worms’ susceptibility towards infection with the adherent-invasive Escherichia Coli LF82, isolated from a patient suffering from Crohn’s disease. Moreover, dietary supplementation with the fatty acid γ-linolenic acid rescued the enhanced pathogen susceptibility of C. elegans lacking a Δ6 desaturase. The fatty acid profile of the nematode is altered upon infection with pathogenic LF82. qRT-PCR analysis allowed to determine that stress and autophagy genes are induced in C. elegans infected with this particular type of E. coli. Autophagy was found to be increased on C. elegans challenged with LF82, as determined by fluorescence microscopy. Collectively these results suggest an important role for PUFAS in the innate immune response and indicate that autophagy may have a contribution for C. elegans response towards the pathogen E. coli LF82.
Osborn, Lucas Jerry. "MICROBIAL METABOLISM OF DIETARY INPUT IN CARDIOMETABOLICDISEASE PATHOGENESIS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1624359488777241.
Повний текст джерелаBaker, Genevieve Elizabeth. "Molecular insights into bacterial fatty acid metabolism." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715811.
Повний текст джерелаKimmitt, Patrick Thomas. "Expression of Shiga toxin genes in Escherichia coli." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299614.
Повний текст джерелаO'Sullivan, A. M. "Microbial factors influencing the pathogenesis of Campylobacter infections." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378924.
Повний текст джерелаMatts, Paul Jonathan. "Bacterial metabolism of short-chain alkyl sulphate esters." Thesis, Cardiff University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304974.
Повний текст джерелаFerreira, Patrícia Daniela Oliveira. "Regulation of iron metabolism in different bacterial infections." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14598.
Повний текст джерелаIron is found in almost all living organisms, playing a central role in host-pathogen interactions and being crucial for both host and pathogens. In the host, iron is a crucial element, since it plays a key role in biological processes such as oxygen transport, biosynthesis of DNA, energy production and regulation of gene expression. However, high concentrations of iron can also be toxic to cells due to the ability to generate hydroxyl radicals. Thus, vertebrates developed proteins to transport and store iron: transferrin and ferritin, respectivetly. Hepcidin is a key protein of iron metabolism, since it binds to ferroportin, the iron exporter, regulating the release of iron to the serum. On the other hand, iron is also fundamental for pathogens that required it to its growth and proliferation, to the expression of virulence factors and to metabolic processes. Thereby, during infection, the host and the pathogen compete by this metal. Pathogens developed multiple strategies to acquire iron from the host during infection. Thus, making iron unavailable for microorganisms is a central mechanism in host defense. In this work, we investigated the regulation of iron metabolism in host during infection with Listeria monocytogenes, a gram-positive bacterium and Salmonella Typhimurium, a gram-negative bacterium in order to verify whether there are alterations in host iron metabolism depending of infection type and if hepcidin have a central role in these alterations. C57BL6 male mice were infected with 104 CFU of L. monocytogenes, S. Typhimurium, or an equivalent volume of vehicle and sacrificed at different time points. Bacterial load quantification, non-heme iron determination in liver, evaluation of iron distribution in tissue, histopathologic analyses and the expression of genes related with iron metabolism were analyzed. Our results show that in both infections with L. monocytogenes and S. Typhimurium the host immune system are not able to irradiate the infection and, thus, the bacterial load increases during the experiment. Regarding the hematological and serological parameters, a reduction of red blood cells and hematocrit is observed, as well as, of serum iron levels. The levels of interleukin-6 and hepcidin increase at different time points in each infection. Additionally, non-heme iron concentration increases in liver during infection with both pathogens. Histopathological alterations were also detected during infection with L monocytogenes and S. Typhimurium. Our data suggests that both infections induce alterations in host iron metabolism. However, the infection with S. Typhimurium appears to have earlier and more severe effects in the host than infection with L. monocytogenes.
O ferro é encontrado em quase todos os seres vivos, desempenhando um papel central nas interacções entre o hospedeiro e o patógeno e sendo essencial para ambos. Para o hospedeiro, o ferro é um elemento crucial, uma vez que desempenha um papel chave em processos biológicos como o transporte de oxigénio, a biossíntese de DNA, produção de energia e regulação da expressão génica. No entanto, elevadas concentrações de ferro também podem ser tóxicas para as células devido à capacidade de gerarem radicais hidroxilo. Assim, os vertebrados possuem proteínas para transportar e armazenar o ferro, a transferrina e a ferritina respetivamente. A hepcidina é uma proteína chave do metabolismo do ferro, uma vez que se liga à ferroportina, o exportador do ferro, regulando a libertação de ferro para o soro. Por outro lado, o ferro é também fundamental para os patógenos, que o requerem para o seu crescimento e proliferação, para a expressão de factores de virulência e para vários processos metabólicos. Assim, durante a infecção, o hospedeiro e o patógeno competem por este metal. Os patógenos desenvolveram múltiplas estratégias para adquirir o ferro a partir do hospedeiro durante a infeção. Deste modo, tornar o ferro indisponível para os microrganismos é um mecanismo central na defesa do hospedeiro. Neste trabalho, investigámos a regulação do metabolismo do ferro no hospedeiro durante a infecção com Listeria monocytogenes, uma bactéria gram-positiva e com Salmonella Typhimurium, uma bactéria gram-negativa, de modo a verificar se existem alterações no metabolismo do ferro do hospedeiro dependendo do tipo de infeção e se a hepcidina tem um papel preponderante nestas alterações. Murganhos machos C57BL6 foram infectados com 104 CFU de L. monocytogenes, S. Typhimurium, ou um volume equivalente de veículo e sacrificados a diferentes tempos experimentais. A quantificação da carga bacteriana, determinação do ferro não hémico no fígado, avaliação da distribuição de ferro no tecido, análise histopatológica e a expressão de genes relacionados com o metabolismo do ferro foram analisados. Os nossos resultados mostram que tanto na infeção com L. monocytogenes como na infeção com S. Typhimurium, o sistema imunitário do hospedeiro não é capaz de irradiar a infeção e, assim, a carga bacteriana aumenta durante a experiência. Em relação aos parâmetros hematológicos e serológicos, é observada a redução da quantidade de eritrócitos e do hematócrito, bem como dos níveis de ferro no soro. Os níveis de interleucina-6 e de hepcidina aumentam em diferentes tempos experimentais em cada infeção. Adicionalmente, a concentração de ferro não hémico aumenta no fígado durante a infeção com ambos os patógenos. Foram também detetadas alterações histopatológicas aquando da infeção com L monocytogenes e S. Typhimurium. Os nossos dados sugerem que ambas as infeções induzem alterações no metabolismo do ferro do hospedeiro. Contudo, a infeção com S. Typhimurium parece ter efeitos mais precoces e mais severos no hospedeiro do que a infeção com L. monocytogenes.
Wiskur, Brandt Justin. "Pathogenesis of Klebsiella pneumoniae endophthalmitis." Oklahoma City : [s.n.], 2008.
Знайти повний текст джерелаGarza-Mayers, Anna Cristina. "Characterization of host and bacterial factors critical for Shigella flexneri pathogenesis." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13064818.
Повний текст джерелаRosario, Sarah. "Bacterial Selenoproteins: A Role in Pathogenesis and Targets for Antimicrobial Development." Doctoral diss., University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2655.
Повний текст джерелаPh.D.
Department of Biomolecular Science
Burnett College of Biomedical Sciences
Biomedical Sciences PhD
Edwards, Kelly Katherine. "Bacterial factors contributing to the pathogenesis of the hemolytic uremic syndrome." MU has:, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3060096.
Повний текст джерелаRoberts, Daniel Paul. "Molecular mechanisms of pathogenesis incited by Erwinia carotovora subsp. carotovora." Diss., Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/71251.
Повний текст джерелаPh. D.
Leiby, Nicholas. "Adaptation and Specialization in the Evolution of Bacterial Metabolism." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11364.
Повний текст джерелаFunk, Michael A. (Michael Andrew). "Structural studies of radical enzymes in bacterial central metabolism." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98816.
Повний текст джерелаVita. Cataloged from PDF version of thesis.
Includes bibliographical references.
Anaerobic bacteria play a crucial role in cycling of nutrients in diverse ecosystems, degradation of organic compounds, and as key members of the human gut microbiome. The absence of oxygen limits the chemistry that bacteria can perform; however, these organisms do make use of organic radical cofactors that are oxygen sensitive. This thesis presents a structural analysis of three enzymes that utilize a glycyl radical cofactor to perform difficult, radical-based chemistry. Benzylsuccinate synthase catalyzes the first step in the anaerobic degradation of toluene, a major component of gasoline and an environmental pollutant. Choline trimethylamine-lyase is used by gut bacteria to degrade choline, producing a byproduct, trimethylamine, which is linked to human diseases. These two enzymes share a common protein fold and also utilize a similar series of steps to initiate chemistry on their substrates. However, once they have generated a radical intermediate, the enzyme active site guides very different chemical steps in these two enzymes. Class III ribonucleotide reductases catalyze the same chemical reaction as observed in aerobic or oxygen independent systems, but utilize a glycyl radical cofactor to initiate chemistry. X-ray crystal structures have given us snapshots of these enzymes in action and accompanying biochemical experiments are help reveal the mechanisms they use to control radical chemistry. These structures have highlighted the potential diversity of chemical reactions available to anaerobic organisms through the use of a conserved enzyme fold.
by Michael A. Funk.
Ph. D. in Biological Chemistry
Gohil, Amit. "Bacterial oxidoreductase-catalysed metabolism of phenol and aniline substrates." Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706684.
Повний текст джерелаRogers, Sarah Victoria. "The biosynthesis of some bacterial and fungal polyketide metabolites." Thesis, Durham University, 1994. http://etheses.dur.ac.uk/5112/.
Повний текст джерелаWard, Philip Nicholas. "Characterisation of an essential c-terminal region of the Pasteurella multiocida toxin." Thesis, University of Hertfordshire, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245402.
Повний текст джерелаCurtis, Richard Nigel. "The role of bacterial superantigen toxins in the pathogenesis of Kawasaki disease." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299621.
Повний текст джерелаRussell, Brandon S. (Brandon Skylur). "Nucleic acid modifications in bacterial pathogens - impact on pathogenesis, diagnosis, and therapy." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/90151.
Повний текст джерелаCataloged from PDF version of thesis.
Includes bibliographical references.
Nucleic acids are subject to extensive chemical modification by all organisms. These modifications display incredible structural diversity, and some are essential for survival. Intriguingly, several of these modifications are unique to bacteria, including many human pathogens. Given the enormous global disease burden due to bacterial infections, and the rapidly increasing rates of antibiotic resistance reported across the world, the need for research to address mechanisms of bacterial survival is more pressing than ever. The goal of this thesis was to determine the function of nucleic acid modifications in pathogenic bacteria, and to evaluate their impact on the three major stages of the infectious disease process: pathogenesis, diagnosis, and therapy. We first used quantitative profiling of tRNA modifications to identify novel stress responses that help mediate host invasion in the world's most common pathogen, Helicobacter pylori. This work uncovered potentially novel targets for the development of new compounds that inhibit pathogenesis. We then developed a new animal model of mycobacterial lung infection that enables drug development and biomarker screening studies in standard laboratories without high-containment facilities. We showed that infection with Mycobacterium bovis bacille Calmette-Guérin produces a granulomatous lung disease in rats that recapitulates many of the important pathological features of human tuberculosis. This model also allowed us to test the utility of nucleic acid modifications as diagnostic biomarkers. Finally, we investigated the effect of the common, transferable bacterial DNA modification phosphorothioation on oxidative and antibiotic stress responses in several pathogens. We showed that phosphorothioation can reduce the effectiveness of antibiotic therapy, which may make it an environmental source of acquired antibiotic resistance. These studies show that nucleic acid modifications play diverse roles in pathogenic bacteria, and that their modulation may be a promising target for developing new tools that can disrupt pathogenesis, improve diagnosis, and strengthen therapy.
by Brandon S. Russell.
Ph. D.
Manoharan, B. "The use of transposon libraries to investigate the evolution of bacterial pathogenesis." Thesis, University of the West of England, Bristol, 2014. http://eprints.uwe.ac.uk/22349/.
Повний текст джерелаMcLaughlin, Simon D. "Clinical and laboratory studies of the bacterial pathogenesis and management of pouchitis." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5713.
Повний текст джерелаClough, Richard R. "The role of energy metabolism in the pathogenesis of Alzheimer's disease." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0004/MQ45034.pdf.
Повний текст джерелаLisanby, Mark W. "Examination of the capacity of cathelicidins to control Bacillus anthracis pathogenesis." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/lisanby.pdf.
Повний текст джерелаOonthonpan, Lalita. "Two human Mitochondrial Pyruvate Carrier mutations reveal distinct mechanisms of molecular pathogenesis." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/7006.
Повний текст джерелаAlday-Sanz, Victoria. "Studies on the pathogenesis of Vibrio spp infection in Penaeus monodon Fabricius." Thesis, University of Stirling, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261671.
Повний текст джерелаAuger, Graham Anthony. "Genetic manipulation of bacterial metabolism by altering a global regulator." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265798.
Повний текст джерелаWinkler, Jonathan Alexander. "Improving antibiotic activity by manipulating bacterial reactive oxygen species metabolism." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12675.
Повний текст джерелаThe discovery of antibiotics was one of the most important medical breakthroughs of the twentieth century, having a broad impact on overall life expectancy and public health. Unfortunately, antibiotic discovery has slowed significantly in recent times and has failed to match the rising incidence of antibiotic-resistant pathogens. Gram-negative pathogens are a particularly troublesome threat, primarily because these bacteria possess an outer membrane that prevents many antibiotics from accessing their primary cellular targets. While the discovery of novel antibiotics could help to address these issues, alternative strategies, such as improving the activity of preexisting antibiotics, are also needed. Bactericidal antibiotics have recently been shown to share a common mechanism of cell death, despite having different primary, cellular targets. This shared mechanism involves the metabolic production of reactive oxygen species (ROS), which can damage proteins, lipids, and nucleic acids, and can ultimately result in bacterial cell death. The body of work described here shows that this common mechanism can be exploited to improve antibiotic activity, regardless of the antibiotic's primary mode of action. First, I will describe how bacterial metabolism can be predictably perturbed to increase endogenous ROS production, and that increasing endogenous ROS is sufficient to enhance bacterial sensitivity to treatments with ROS-generating biocides, antibiotics, and immune cell attack. I will then describe work indicating that an ancient antimicrobial agent, silver salts, can also increase endogenous ROS production and potentiate the activity of multiple antibiotic classes. Furthermore, I show that silver salts can increase the outer membrane permeability of a Gram-negative organism. This property is exploited to enable vancomycin, an antibiotic that is specific for Gram-positive bacteria, to work against a Gram-negative organism. Together, this body of work demonstrates that bacterial ROS metabolism can be exploited effectively to enhance. antibiotic activity, which ultimately could result in the discovery and development of novel antimicrobial agents.
Keerthisingam, Carmel Beulin. "Role of prostaglandin Eâ‚‚ in the pathogenesis of pulmonary fibrosis." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325631.
Повний текст джерелаThalme, Anders. "Infectious endocarditis, aspects on pathogenesis, diagnosis and prognosis /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-361-2/.
Повний текст джерелаPurdy, Shona Thomson. "The biochemistry and genetics of sorbitol metabolism in clostridium pasteurianum." Thesis, Heriot-Watt University, 1991. http://hdl.handle.net/10399/870.
Повний текст джерелаBröms, Jeanette. "Type III secretion- the various functions of the translocon operon in bacterial pathogenesis." Doctoral thesis, Umeå University, Molecular Biology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-331.
Повний текст джерелаIn order to establish colonisation of a human host, pathogenic Yersinia use a type III protein secretion system to directly intoxicate host immune cells. Activation of this system requires target cell contact and is a highly regulated process. Both the intoxication and regulation events depend on the lcrGVHyopBD translocon operon, which is highly conserved in many bacterial pathogens. In this study, the role of individual operon members was analysed and functional domains identified by using the highly homologous pcrGVHpopBD operon of P. aeruginosa as a comparative tool.
Yersinia spp. and P. aeruginosa were shown to form translocation pores of a similar size that promoted equally efficient protein delivery. A strong dependency on interactions between native translocator(s) in protein delivery was revealed, suggesting that each pathogen has delicately fine-tuned this process to suit its own infection niche. In particular, the C-terminus of YopD was shown to possess functional specificity for effector delivery in Yersinia that could not be conferred by the comparable region in homologous PopD. Moreover, a role for LcrV and PcrV in substrate recognition during the protein delivery process was excluded.
The N-terminus of LcrH was recognized as a unique regulatory domain, mediating formation of LcrH-YscY regulatory complexes in Yersinia, while equivalent complexes with analogous proteins were not formed in P. aeruginosa. These results compliment the idea that a negative regulatory pathway involving LcrH, YopD, LcrQ and YscY is unique to Yersinia.
Finally, PcrH was identified as a new member of the translocator class of chaperones, being essential for assembly of a functional PopB/PopD mediated translocon in P. aeruginosa. However, in contrast to the other members of this family, PcrH was dispensable for type III regulation. Moreover, both LcrH and PcrH were shown to possess tetratricopeptide repeats crucial for their chaperone function. One tetratricopeptide repeat mutant in LcrH was even isolated that failed to secrete both YopB and YopD substrates, even though stability was maintained. This demonstrates for the first time that LcrH has a role in substrate secretion in addition to its critical role in promoting substrate stability.
Sze, Marc Alexander. "The bacterial lung tissue microbiome in the pathogenesis of chronic obstructive pulmonary disease." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54530.
Повний текст джерелаMedicine, Faculty of
Medicine, Department of
Experimental Medicine, Division of
Graduate
Bröms, Jeanette. "Type III secretion- the various functions of the translocon operon in bacterial pathogenesis /." Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-331.
Повний текст джерелаKumar, Prashant. "CyclicAMP-PKA signaling in pathogen host interplay role in pathogenesis and bacterial invasion." Berlin mbv, 2009. http://d-nb.info/998089265/04.
Повний текст джерелаCowie, Danielle. "Iron and Tuberculosis pathogenesis." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86566.
Повний текст джерелаENGLISH ABSTRACT: Iron is an essential element that plays a role in the process of respiration, oxygen transport and as a principle cofactor to several enzymes. Iron homeostasis is a finely regulated process since excess levels become toxic to healthy cells via the production of reactive oxygen species. A plethora of genes that control several key points throughout this regulatory process have been identified. Research focusing on changes in expression levels and downstream functional effects of these genes has become increasingly important over the past decade. One area of particular interest has emerged since a link between iron status and host response to Mycobacterium tuberculosis infection was discovered. Although the prevalence of Tuberculosis has decreased across the globe with the exception of Africa and parts of Europe, the mortality rate remains high. Therefore, research that focuses on understanding an individual’s predetermined susceptibility to TB infection at the genetic level could provide health care practitioners with the tools required to identify and educate at-risk individuals prior to TB infection. RT-qPCR was utilised to determine expression profiles for eight iron genes (CP, CYBRD1, FTH, FTL, LTF, HFE, HMOX1, and SCL40A1) normalised to three reference genes (ACTB, GUSB, and RPL37A1). Up-regulation is demonstrated in the TB group for transcript levels recorded for CYBRD1, HFE, HMOX1, and SLC40A1. Several measured serum parameters including conjugated, unconjugated, total bilirubin, and total protein were increased in the TB group while albumin was significantly lower in this group. Correlation analysis demonstrated that a positive correlation exists between transferrin saturation and iron and a negative correlation exists between transferrin and ferritin levels. Individuals categorised with low serum iron levels demonstrated lower CP/GUSB levels and higher HMOX1/GUSB levels. Individuals categorised with low transferrin saturation levels demonstrated higher FTL/GUSB and SLC40A1/GUSB levels and lower CP/GUSB. Results from this study provide further evidence for the relationship between iron status and TB infection rates, although protein studies are required to confirm these results. The data obtained illustrate the important role that these profiles and iron parameters may play in the clinical field when identifying at-risk individuals. Further investigation that focuses on which gene profile and parameter combinations show the most distinctive utility in the clinical setting is warranted.
AFRIKAANSE OPSOMMING: Yster is ‘n noodsaaklike element wat ‘n rol speel in die proses van respirasie en die vervoer van suurstof en ook ‘n belangrike ko-faktor vir verskeie ensieme is. Yster homeostase is op ‘n fyn manier gereguleer omdat oormatige vlakke toksies kan wees vir gesonde selle wanneer reaktiewe suurstofspesies geproduseer word. ‘n Magdom gene wat verskeie sleutelpunte in hierdie proses kontroleer is voorheen identifiseer. Navorsing wat fokus op die veranderinge in geenuitdrukkingsvlakke en die funksionele gevolge daarvan het oor die afgelope dekade toenemend belangrik geword. Een gebied van spesifieke belang het na vore gekom nadat ‘n verband tussen ystervlakke en die manier waarop die immuunstelsel reageer op Mycobacterium tuberculosis infeksie, ontdek is. Alhoewel die voorkoms van Tuberkulose wêreldwyd, behalwe in Afrika en sekere dele van Europa, afgeneem het, bly die sterftesyfer hoog. Daarom kan navorsing wat daarop fokus om ‘n individu se voorafbepaalde vatbaarheid vir TB-infeksie op die genetiese vlak te verstaan dalk aan gesondheidswerkers die regte instrumente verskaf om hoë-risiko individue te identifiseer en op te voed voordat hulle TB ontwikkel. RT-qPKR is gebruik om die geenuitdrukkingsvlakke van agt ystergene, wat met drie verwysings-gene (ACTB, GUSB, en RPL37A1) genormaliseer is, te bepaal. ‘n Toename in die uitdrukkingsvlakke van CYBRD1, HFE, HMOX1, en SLC40A1 is in die TB-groep waargeneem. Die bloedvlakke van verskeie parameters insluitend gekonjugeerde, ongekonjugeerde, totale bilirubin, en totale proteïen was hoër in die TB-groep, terwyl albuminvlakke laer was in hierdie groep. Korrelasie-analise het ‘n positiewe korrelasie tussen transferrin-versadiging en yster getoon, terwyl daar ‘n negatiewe korrelasie tussen transferrin- en ferritinvlakke gevind is. Individue met lae ystervlakke het laer CP/GUSB-vlakke en hoër HMOX1/GUSB-vlakke getoon. Individue met lae transferrin-versadiging het hoër FTL/GUSB- en SLC40A1/GUSB-vlakke en laer CP/GUSB-vlakke getoon. Resultate uit hierdie studie verskaf verdere getuienis dat daar ‘n verwantskap tussen ystervlakke en TB-infeksiekoerse bestaan, alhoewel proteïenstudies nodig is om hierdie resultate te bevestig. Die data dui op die belangrike rol wat hierdie profiele en ystervlakke in die kliniese veld mag speel in die identifisering van hoë-risiko individue. Verdere ondersoek, gefokus op watter geenprofiel en parameterkombinasies die grootste nut in die kliniese omgewing bied, is geregverdig.
Bian, Zhao. "Nucleator-driven assembly of curli organelles and their pathophysiological role in E. coli septic shock /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3688-9/.
Повний текст джерелаDunstan, R. H. "A GC-MS approach to carbon and nitrogen metabolism in Paracoccus denitrificans." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370248.
Повний текст джерелаOberbeck, Nina. "The role of intrauterine aldehyde catabolism in the pathogenesis of Fanconi anaemia." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708527.
Повний текст джерелаIsmaili, Arif. "Signal transduction and cytoskeletal responses in the pathogenesis of attaching and effacing bacterial infection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ33906.pdf.
Повний текст джерелаScott, Euan. "Probing the bacterial pathogenesis of ESKAPE species utilising C. elegans as a model system." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/422278/.
Повний текст джерелаDarby, Creg Burns. "Paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa : a genetically tractable model for bacterial pathogenesis /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/10304.
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