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Статті в журналах з теми "Backbone Modification"
Servatius, Phil, Lukas Junk, and Uli Kazmaier. "Peptide Modifications: Versatile Tools in Peptide and Natural Product Syntheses." Synlett 30, no. 11 (April 2, 2019): 1289–302. http://dx.doi.org/10.1055/s-0037-1612417.
Повний текст джерелаRehpenn, Andreas, Alexandra Walter, and Golo Storch. "Molecular Editing of Flavins for Catalysis." Synthesis 53, no. 15 (March 22, 2021): 2583–93. http://dx.doi.org/10.1055/a-1458-2419.
Повний текст джерелаSchmidtgall, Boris, Claudia Höbartner, and Christian Ducho. "NAA-modified DNA oligonucleotides with zwitterionic backbones: stereoselective synthesis of A–T phosphoramidite building blocks." Beilstein Journal of Organic Chemistry 11 (January 13, 2015): 50–60. http://dx.doi.org/10.3762/bjoc.11.8.
Повний текст джерелаMeng, Melissa, Boris Schmidtgall, and Christian Ducho. "Enhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological Media." Molecules 23, no. 11 (November 10, 2018): 2941. http://dx.doi.org/10.3390/molecules23112941.
Повний текст джерелаChang, Chi-Fon, and Micheal H. Zehfus. "Effects of backbone modification on helical peptides: The reduced carbonyl modification." Biopolymers 46, no. 3 (September 1998): 181–93. http://dx.doi.org/10.1002/(sici)1097-0282(199809)46:3<181::aid-bip5>3.0.co;2-h.
Повний текст джерелаDawson, Philip E., Gangamani Beligere, and Liang Yan. "Modification of the polypeptide backbone using chemical synthesis." Journal of Molecular Graphics and Modelling 18, no. 4-5 (2000): 550. http://dx.doi.org/10.1016/s1093-3263(00)80112-6.
Повний текст джерелаShaykhutdinova, Polina, and Martin Oestreich. "Further Structural Modification of Sulfur-Stabilized Silicon Cations with Binaphthyl Backbones." Synthesis 51, no. 10 (March 11, 2019): 2221–29. http://dx.doi.org/10.1055/s-0037-1610697.
Повний текст джерелаFan, Linmeng, Min Du, Lichun Kong, Yan Cai, and Xiaobo Hu. "Recognition Site Modifiable Macrocycle: Synthesis, Functional Group Variation and Structural Inspection." Molecules 28, no. 3 (January 31, 2023): 1338. http://dx.doi.org/10.3390/molecules28031338.
Повний текст джерелаMazo, Nuria, Claudio D. Navo, Jesús M. Peregrina, Jesús H. Busto, and Gonzalo Jiménez-Osés. "Selective modification of sulfamidate-containing peptides." Organic & Biomolecular Chemistry 18, no. 32 (2020): 6265–75. http://dx.doi.org/10.1039/d0ob01061h.
Повний текст джерелаStrąkowska, Anna, Anna Kosmalska, and Marian Zaborski. "Silsesquioxanes as Modifying Agents of Methylvinylsilicone Rubber." Materials Science Forum 714 (March 2012): 183–89. http://dx.doi.org/10.4028/www.scientific.net/msf.714.183.
Повний текст джерелаДисертації з теми "Backbone Modification"
Dysko, Anna Monika. "Synthesis and properties of oligonucleotides containing triazole backbone linkages and 2'-modifications for therapeutic applications." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:20fc1203-9751-4654-b497-5f4d97f874a1.
Повний текст джерелаMoreira, Ana Sofia Pereira. "Study of modifications induced by thermal and oxidative treatment in oligo and polysaccharides of coffee by mass spectrometry." Doctoral thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17074.
Повний текст джерелаOs polissacarídeos são os componentes maioritários dos grãos de café verde e torrado e da bebida de café. Os mais abundantes são as galactomananas, seguindo-se as arabinogalactanas. Durante o processo de torra, as galactomananas e arabinogalactanas sofrem modificações estruturais, as quais estão longe de estar completamente elucidadas devido à sua diversidade e à complexidade estrutural dos compostos formados. Durante o processo de torra, as galactomananas e arabinogalactanas reagem com proteínas, ácidos clorogénicos e sacarose, originando compostos castanhos de alto peso molecular contendo nitrogénio, designados de melanoidinas. As melanoidinas do café apresentam diversas atividades biológicas e efeitos benéficos para a saúde. No entanto, a sua estrutura exata e os mecanismos envolvidos na sua formação permanecem desconhecidos, bem como a relação estrutura-atividade biológica. A utilização de sistemas modelo e a análise por espectrometria de massa permitem obter uma visão global e, simultaneamente, detalhada das modificações estruturais nos polissacarídeos do café promovidas pela torra, contribuindo para a elucidação das estruturas e mecanismos de formação das melanoidinas. Com base nesta tese, oligossacarídeos estruturalmente relacionados com a cadeia principal das galactomananas, (β1→4)-Dmanotriose (Man3), e as cadeias laterais das arabinogalactanas, (α1→5)-Larabinotriose (Ara3), isoladamente ou em misturas com ácido 5-Ocafeoilquínico (5-CQA), o ácido clorogénico mais abundante nos grãos de café verde, e péptidos compostos por tirosina e leucina, usados como modelos das proteínas, foram sujeitos a tratamento térmico a seco, mimetizando o processo de torra. A oxidação induzida por radicais hidroxilo (HO•) foi também estudada, uma vez que estes radicais parecem estar envolvidos na modificação dos polissacarídeos durante a torra. A identificação das modificações estruturais induzidas por tratamento térmico e oxidativo dos compostos modelo foi feita por estratégias analíticas baseadas principalmente em espectrometria de massa, mas também em cromatografia líquida. A cromatografia de gás foi usada na análise de açúcares neutros e ligações glicosídicas. Para validar as conclusões obtidas com os compostos modelo, foram também analisadas amostras de polissacarídeos do café obtidas a partir de resíduo de café e café instantâneo. Os resultados obtidos a partir dos oligossacarídeos modelo quando submetidos a tratamento térmico (seco), assim como à oxidação induzida por HO• (em solução), indicam a ocorrência de despolimerização, o que está de acordo com estudos anteriores que reportam a despolimerização das galactomananas e arabinogalactanas do café durante a torra. Foram ainda identificados outros compostos resultantes da quebra do anel de açúcares formados durante o tratamento térmico e oxidativo da Ara3. Por outro lado, o tratamento térmico a seco dos oligossacarídeos modelo (individualmente ou quando misturados) promoveu a formação de oligossacarídeos com um maior grau de polimerização, e também polissacarídeos com novos tipos de ligações glicosídicas, evidenciando a ocorrência de polimerização através reações de transglicosilação não enzimática induzidas por tratamento térmico a seco. As reações de transglicosilação induzidas por tratamento térmico a seco podem ocorrer entre resíduos de açúcares provenientes da mesma origem, mas também de origens diferentes com formação de estruturas híbridas, contendo arabinose e manose como observado nos casos dos compostos modelo usados. Os resultados obtidos a partir de amostras do resíduo de café e de café instantâneo sugerem a presença de polissacarídeos híbridos nestas amostras de café processado, corroborando a ocorrência de transglicosilação durante o processo de torra. Além disso, o estudo de misturas contendo diferentes proporções de cada oligossacarídeo modelo, mimetizando regiões do grão de café com composição distinta em polissacarídeos, sujeitos a diferentes períodos de tratamento térmico, permitiu inferir que diferentes estruturas híbridas e não híbridas podem ser formadas a partir das arabinogalactanas e galactomananas, dependendo da sua distribuição nas paredes celulares do grão e das condições de torra. Estes resultados podem explicar a heterogeneidade de estruturas de melanoidinas formadas durante a torra do café. Os resultados obtidos a partir de misturas modelo contendo um oligossacarídeo (Ara3 ou Man3) e 5-CQA sujeitas a tratamento térmico a seco, assim como de amostras provenientes do resíduo de café, mostraram a formação de compostos híbridos compostos por moléculas de CQA ligadas covalentemente a um número variável de resíduos de açúcar. Além disso, os resultados obtidos a partir da mistura contendo Man3 e 5-CQA mostraram que o CQA atua como catalisador das reações de transglicosilação. Por outro lado, nas misturas modelo contendo um péptido, mesmo contendo também 5-CQA e sujeitas ao mesmo tratamento, observou-se uma diminuição na extensão das reações transglicosilação. Este resultado pode explicar a baixa extensão das reações de transglicosilação não enzimáticas durante a torra nas regiões do grão de café mais ricas em proteínas, apesar dos polissacarídeos serem os componentes maioritários dos grãos de café. A diminuição das reações de transglicosilação na presença de péptidos/proteínas pode dever-se ao facto de os resíduos de açúcares redutores reagirem preferencialmente com os grupos amina de péptidos/proteínas por reação de Maillard, diminuindo o número de resíduos de açúcares redutores disponíveis para as reações de transglicosilação. Além dos compostos já descritos, uma diversidade de outros compostos foram formados a partir dos sistemas modelo, nomeadamente derivados de desidratação formados durante o tratamento térmico a seco. Em conclusão, a tipificação das modificações estruturais promovidas pela torra nos polissacarídeos do café abre o caminho para a compreensão dos mecanismos de formação das melanoidinas e da relação estrutura-atividade destes compostos.
Polysaccharides are the major components of green and roasted coffee beans, and coffee brew. The most abundant ones are galactomannans, followed by arabinogalactans. During the roasting process, galactomannans and arabinogalactans undergo structural modifications that are far to be completely elucidated due to their diversity and complexity of the compounds formed. During the roasting process, galactomannans and arabinogalactans react with proteins, chlorogenic acids, and sucrose, originating high molecular weight brown compounds containing nitrogen, known as melanoidins. Several biological activities and beneficial health effects have been attributed to coffee melanoidins. However, their exact structures and the mechanisms involved in their formation remain unknown, as well as the structure-biological activity relationship. The use of model systems and mass spectrometry analysis allow to obtain an overall view and, simultaneously, detailed, of the structural modifications in coffee polysaccharides promoted by roasting, contributing to the elucidation of the structures and formation mechanisms of melanoidins. Based on this thesis, oligosaccharides structurally related to the backbone of galactomannans, (β1→4)-D-mannotriose, and the side chains of arabinogalactans, (α1→5)-Larabinotriose, alone or in mixtures with 5-O-caffeoylquinic acid, the most abundant chlorogenic acid in green coffee beans, and dipeptides composed by tyrosine and leucine, used as models of proteins, were submitted to dry thermal treatments, mimicking the coffee roasting process. The oxidation induced by hydroxyl radicals (HO•) was also studied, since these radicals seem to be involved in the modification of the polysaccharides during roasting. The identification of the structural modifications induced by thermal and oxidative treatment of the model compounds was performed mostly by mass spectrometry-based analytical strategies, but also using liquid chromatography. Gas chromatography was used in the analysis of neutral sugars and glycosidic linkages. To validate the conclusions achieved with the model compounds, coffee polysaccharide samples obtained from spent coffee grounds and instant coffee were also analysed. The results obtained from the model oligosaccharides when submitted to thermal treatment (dry) or oxidation induced by HO• (in solution) indicate the occurrence of depolymerization, which is in line with previous studies reporting the depolymerization of coffee galactomannans and arabinogalactans during roasting. Compounds resulting from sugar ring cleavage were also formed during thermal treatment and oxidative treatment of Ara3. On the other hand, the dry thermal treatment of the model oligosaccharides (alone or when mixed) promoted the formation of oligosaccharides with a higher degree of polymerization, and also polysaccharides with new type of glycosidic linkages, evidencing the occurrence of polymerization via non-enzymatic transglycosylation reactions induced by dry thermal treatment. The transglycosylation reactions induced by dry thermal treatment can occur between sugar residues from the same origin, but also of different origins, with formation of hybrid structures, containing arabinose and mannose in the case of the model compounds used. The results obtained from spent coffee grounds and instant coffee samples suggest the presence of hybrid polysaccharides in these processed coffee samples, corroborating the occurrence of transglycosylation during the roasting process. Furthermore, the study of mixtures containing different proportions of each model oligosaccharide, mimicking coffee bean regions with distinct polysaccharide composition, subjected to different periods of thermal treatment, allowed to infer that different hybrid and non-hybrid structures may be formed from arabinogalactans and galactomannans, depending on their distribution in the bean cell walls and on roasting conditions. These results may explain the heterogeneity of melanoidins structures formed during coffee roasting. The results obtained from model mixtures containing an oligosaccharide (Ara3 or Man3) and 5-CQA and subjected to dry thermal treatment, as well as samples derived from spent coffee grounds, showed the formation of hybrid compounds composed by CQA molecules covalently linked to a variable number of sugar residues. Moreover, the results obtained from the mixture containing Man3 and 5-CQA showed that CQA acts as catalyst of transglycosylation reactions. On the other hand, in the model mixtures containing a peptide, even if containing 5-CQA and subjected to the same treatment, it was observed a decrease in the extent of transglycosylation reactions. This outcome can explain the low extent of non-enzymatic transglycosylation reactions during roasting in coffee bean regions enriched in proteins, although polysaccharides are the major components of the coffee beans. The decrease of transglycosylation reactions in the presence of peptides/proteins can be related with the preferential reactivity of reducing residues with the amino groups of peptides/proteins by Maillard reaction, decreasing the number of reducing residues available to be directly involved in the transglycosylation reactions. In addition to the compounds already described, a diversity of other compounds were formed from model systems, namely dehydrated derivatives formed during dry thermal treatment. In conclusion, the identification of the structural modifications in coffee polysaccharides promoted by roasting pave the way to the understanding of the mechanisms of formation of melanoidins and structure-activity relationship of these compounds.
Ghosh, Pritha. "Insights into the conformational stability & pharmacology of peptides through side chain and backbone modification." Thesis, 2022. https://etd.iisc.ac.in/handle/2005/5888.
Повний текст джерелаMoE
Boersma, Melissa D. "Engineering the affinity and selectivity of peptide-based inhibitors of protein-protein interactions through side chain and backbone modification." 2008. http://www.library.wisc.edu/databases/connect/dissertations.html.
Повний текст джерелаKhatri, Bhavesh. "Exploring Nature's Inventory: Investigating the Role of Amide to Thioamide Substitution on Protein Stability." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/5635.
Повний текст джерелаVamadevan, Varatharajan. "Organization of Glucan Chains in Starch Granules as Revealed by Hydrothermal Treatment." Thesis, 2013. http://hdl.handle.net/10214/7240.
Повний текст джерелаКниги з теми "Backbone Modification"
Synthetic and Enzymatic Modifications of the Peptide Backbone. Elsevier, 2021. http://dx.doi.org/10.1016/s0076-6879(21)x0012-2.
Повний текст джерелаPetersson, E. James. Synthetic and Enzymatic Modifications of the Peptide Backbone. Academic Press, 2021.
Знайти повний текст джерелаPetersson, E. James. Synthetic and Enzymatic Modifications of the Peptide Backbone. Elsevier Science & Technology Books, 2021.
Знайти повний текст джерелаde Bruijne, Arnoud, Joop van Buren, Anton Kösters, and Hans van der Marel. Geodetic reference frames in the Netherlands. Nederlandse Commissie voor Geodesie, 2005. http://dx.doi.org/10.54419/vy3c94.
Повний текст джерелаЧастини книг з теми "Backbone Modification"
Gait, Michael J., and Sudhir Agrawal. "Introduction and History of the Chemistry of Nucleic Acids Therapeutics." In Methods in Molecular Biology, 3–31. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_1.
Повний текст джерелаKohn, Joachim, and Robert Langer. "Backbone modification of synthetic poly-α-L-amino acids." In Peptides, 658–61. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-010-9595-2_198.
Повний текст джерелаHuang, Dong-Liang, Ying Li, and Ji-Shen Zheng. "Removable Backbone Modification (RBM) Strategy for the Chemical Synthesis of Hydrophobic Peptides/Proteins." In Methods in Molecular Biology, 241–56. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2489-0_16.
Повний текст джерелаRozners, Eriks. "Amides and Other Nonionic Backbone Modifications in RNA." In Handbook of Chemical Biology of Nucleic Acids, 2339–59. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-9776-1_76.
Повний текст джерелаRozners, Eriks. "Amides and Other Nonionic Backbone Modifications in RNA." In Handbook of Chemical Biology of Nucleic Acids, 1–21. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-16-1313-5_76-1.
Повний текст джерелаPrécigoux, G., Y. Barrans, S. Geoffre, P. Picard, and M. Hospital. "RENIN INHIBITORS AND SUBSTRATES: CONFORMATIONAL EFFECT OF PEPTIDE BACKBONE MODIFICATIONS." In Porto Carras, Chalkidiki, Greece, Aug. 31–Sept. 5, 1986, edited by Dimitrios Theodoropoulos, 323–26. Berlin, Boston: De Gruyter, 1987. http://dx.doi.org/10.1515/9783110864243-074.
Повний текст джерелаGoto, Yuki, and Hiroaki Suga. "Ribosomal Synthesis of Peptides Bearing Noncanonical Backbone Structures via Chemical Posttranslational Modifications." In Methods in Molecular Biology, 255–66. New York, NY: Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3214-7_13.
Повний текст джерелаTaillard, Éric D. "Local Search." In Design of Heuristic Algorithms for Hard Optimization, 103–29. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-13714-3_5.
Повний текст джерелаMa, Sougen, and Arno F. Spatola. "Compatibility studies of Ψ[CH2NH2 +] / ψ[CH2NH] backbone modifications with reverse turn structures." In Peptides, 777–78. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_313.
Повний текст джерелаWang, Xu, Jens Pfannstiel, Annick Stintzi, and Andreas Schaller. "Peptide Backbone Modifications for the Assessment of Cleavage Site Relevance in Precursors of Signaling Peptides." In Methods in Molecular Biology, 83–93. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2079-3_7.
Повний текст джерелаТези доповідей конференцій з теми "Backbone Modification"
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Повний текст джерелаYuan, Rong, Xuedong Chen, and Weihe Guan. "Nondestructive Inspection of Pressure-Bearing Equipment in China." In ASME 2008 Pressure Vessels and Piping Conference. ASMEDC, 2008. http://dx.doi.org/10.1115/pvp2008-61448.
Повний текст джерелаWilson, Gregory C., and Keith D. Wooten. "Calculation Cross-Reference Database." In 2002 International Joint Power Generation Conference. ASMEDC, 2002. http://dx.doi.org/10.1115/ijpgc2002-26120.
Повний текст джерелаEviany, Ameria, Ifani Ramadhani, Cio Mario, Anang Nugrahanto, Harris Pramana, and Anom Seto Murtani. "An Outright Success in Oil and Gas Production Arise from Surface Facility Modification – Story of Ujung Pangkah Field." In SPE/IATMI Asia Pacific Oil & Gas Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/205728-ms.
Повний текст джерелаLiu, Jen-Yu, and Yi-Hsuan Yang. "Dilated Convolution with Dilated GRU for Music Source Separation." In Twenty-Eighth International Joint Conference on Artificial Intelligence {IJCAI-19}. California: International Joint Conferences on Artificial Intelligence Organization, 2019. http://dx.doi.org/10.24963/ijcai.2019/655.
Повний текст джерелаPerminova, Irina. "Humics-Based Chemicals and Materials Designed for Ecoadaptive Chemistry and Technology." In 20TH CONFERENCE OF THE INTERNATIONAL HUMIC SUBSTANCES SOCIETY. Non-Commercial Partnership "Center for Biogenic Resources "Humus Sapiens" (NP CBR "Humus Sapiens"), 2021. http://dx.doi.org/10.36291/ihss.2021.perminova.
Повний текст джерелаPrêtre, Ph, P. G. Kaatz, A. Bohren, P. Günter, B. Zysset, M. Ahlheim, and F. Lehr. "Modified Polyimide Polymers for Electro-Optic Applications." In Organic Thin Films for Photonic Applications. Washington, D.C.: Optica Publishing Group, 1993. http://dx.doi.org/10.1364/otfa.1993.wa.7.
Повний текст джерелаG., Harold, Branden Sletteland, and Max Taylor. "Future Vertical Lift Digital Backbone, Navigating Technology and Implementation Details." In Vertical Flight Society 76th Annual Forum & Technology Display. The Vertical Flight Society, 2020. http://dx.doi.org/10.4050/f-0076-2020-16431.
Повний текст джерелаRobson, Nina, Bin Yun Chen, Jong-Seob Won, and Gim Song Soh. "Creating Robust Passive Multi-Loop Wearable Hand Devices." In ASME 2019 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/detc2019-97623.
Повний текст джерела