Дисертації з теми "Bac7"
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Mardirossian, Mario. "Internal targets and killing mechanism of the cathelicidin Bac7 in Gram-negative bacteria." Doctoral thesis, Università degli studi di Trieste, 2013. http://hdl.handle.net/10077/8640.
Повний текст джерелаBac7(1-35) is the smallest fragment of the proline-rich cathelicidin Bac7 that shows the same antibacterial activity as the whole natural peptide of 60 residues. In this work, we remarked that the unique gene whose deletion can confer resistance to E. coli against Bac7(1-35) is sbmA, coding for an inner membrane protein involved in the penetration of this peptide into bacterial cells. Moreover, we provided evidence that SbmA is also involved in the transmembrane transport of a fragment of another proline-rich antimicrobial peptide, arasin1(1-23), isolated from the spider crab. These findings suggest a general role of this membrane protein in the uptake of proline-rich antimicrobial peptides (PR-AMPs) into Gram-negative bacteria. We then measured the intrabacterial concentration reached by Bac7(1-35) in E. coli, and observed that this increases from micromolar in the medium to millimolar within the bacterial cell, suggesting that it may bind to cytosolic structures. For this reason, we looked for possible interactions between Bac7(1-35) and macromolecules involved in viable processes of bacteria. These studies showed that Bac7(1-35) completely inhibits in vitro the transcription/translation process starting from a concentration of 50 μM. Then we demonstrated that inhibition is: i) specific for Bac7(1-35), since it is not exerted by other cathelicidin-derived AMPs not belonging to the Prorich group, and ii) not stereo-specific, since it is exerted at the same level by the all-D isomer of Bac7(1-35). We also demonstrated the ability of Bac7(1-35) to bind DNA in vitro, but we excluded that this binding may represent the primary mechanism of bactericidal action. We also showed that the peptide does not significantly affect in vitro the transcription process, deducing that the inhibition of the transcription/translation targets primarily the translation process. We verified these data in vivo on E. coli cells measuring the incorporation of radioactive precursors of bacterial macromolecules. We observed that the exposure of bacteria to Bac7(1-35) inhibited the incorporation of radioactive leucine, but not of radioactive thymidine and uridine, indicating a specific block at the protein synthesis level and not of DNA and RNA synthesis. In the near future, a clearer definition of the intrabacterial target(s) of Bac7(1-35) would hopefully lead to the experimentation of this molecule or of its derivatives as a new generation antibiotic drug.
Bac7(1-35) è il più breve frammento del peptide Bac7, una catelicidina ricca in prolina di 60 residui, dotato della stessa attività battericida del peptide intero. In questo lavoro di tesi, abbiamo rimarcato che sbmA è l’unico gene la cui delezione conferisce ad E. coli una resistenza a Bac7(1- 35). Tale gene codifica per una proteina della membrana interna coinvolta nell’ingresso del peptide nel citoplasma della cellula batterica. Inoltre, abbiamo dimostrato che SbmA è coinvolta anche nel trasporto transmembrana di un frammento di un altro peptide antimicrobico, l’arasina1(1-23). Tali risultati suggeriscono che questa proteina giochi un ruolo generale nell’internalizzazione di peptidi antimicrobici ricchi in prolina nei batteri Gram-negativi. Abbiamo quindi misurato la concentrazione intrabatterica raggiunta da Bac7(1-35) in E. coli e abbiamo osservato che questa aumenta da valori micromolari nel terreno di coltura a millimolari nel citosol batterico, suggerendo un suo legame a strutture interne della cellula. Per questo abbiamo cercato possibili interazioni tra il peptide e macromolecole coinvolte in processi vitali del batterio. Con questi studi abbiamo appurato che Bac7(1-35) in vitro inibisce completamente il processo di trascrizione/traduzione a partire da una concentrazione di 50 μM. Successivamente abbiamo dimostrato che questa inibizione è una peculiarità di Bac7(1-35), in quanto altri AMP derivati da catelicidine ma non ricchi in prolina non hanno dimostrato un’attività comparabile. Inoltre, questa inibizione non è stereo-specifica, in quanto anche l’isomero D di Bac7(1-35) blocca tale processo esattamente come il suo isomero L. Abbiamo inoltre dimostrato la capacità di Bac7(1-35) di legare in vitro il DNA, ma abbiamo escluso che tale legame rappresenti il meccanismo primario della sua attività battericida. Abbiamo anche dimostrato che il peptide non interferisce in vitro in maniera significativa con il processo di trascrizione, deducendo che l’effetto osservato sul processo di trascrizione/traduzione fosse da attribuirsi prevalentemente all’inibizione della traduzione. Abbiamo verificato tali dati in vivo su cellule di E. coli misurando l’incorporazione di precursori radioattivi delle macromolecole batteriche. Abbiamo osservato che l’esposizione di batteri a Bac7(1-35) bloccava l’incorporazione di leucina radioattiva ma non di timidina ed uridina, indicando un blocco specifico della sintesi proteica ma non di quelle di DNA e RNA. In futuro, una definizione ancora più chiara del target intrabatterico di Bac7(1-35) potrebbe portare alla sperimentazione di tale molecola o di suoi analoghi come farmaci antibiotici di nuova generazione.
XXV Ciclo
1985
Chettaf, Aïssa. "Contribution à l'étude du séchage par rayonnement infrarouge : Application au séchage en couche mince d'une enduction." Valenciennes, 1994. https://ged.uphf.fr/nuxeo/site/esupversions/9a259158-201e-4807-bac7-56fdaf6a482b.
Повний текст джерелаPelillo, Chiara. "Therapeutic potential of BAC7(I-35), a Proline-rich Antimicrobial Peptide: in vitro and in vivo studies and Pegylation strategy to improve its bioavailability." Doctoral thesis, Università degli studi di Trieste, 2011. http://hdl.handle.net/10077/5978.
Повний текст джерелаThe antimicrobial peptides (AMPs) are an important component of the innate defense against invading microorganisms, are widespread in nature and may have multiple and diversified mechanisms of bactericidal action. In addition to their direct antimicrobial activity the are also involved in other biological processes. The aim of this project was to investigate the in vivo activity of Bac7(1-35), a bovine proline-rich antimicrobial peptide, having in mind its possible use as a lead compound for the development of novel anti-infective agents. Before moving to animal models of infection, the in vitro stability of the peptide in the presence of murine and human serum or plasma as well as its biodistribution in mouse were investigated. Antibacterial activity assays against Salmonella enterica showed that the presence of murine blood components largely inhibits the antibacterial activity of the peptide. On the contrary, in human serum and plasma Bac7(1-35) maintains its efficacy. This is due to the more rapid degradation by proteases of murine blood. The in vivo biodistribution of Bac7(1-35) was investigated by using a time-domain optical imaging apparatus and a fluorescently-labeled Bac7(1-35) derivative. The compound reaches the kidney and the bladder respectively 1 and 3 hours after i.p. injection. The in vivo and ex vivo analyses performed after 24 h confirm that the compound has been totally excreted. A mouse model of S. typhimurium infection was set up and used to test the therapeutic efficacy of Bac7(1-35). Treatment of infected mice with the peptide injected i.p. immediately after a lethal, intraperithoneal bacterial challenge, increased the mean survival time and reduced significantly the number of viable bacterial cells in liver and spleen of treated mice at 3 days post-inoculum. In 1/3 of the organ homogenates, the bacterial presence was undetectable and this result matches the percentage of cured animals (35%). In an attempt to improve its pharmacokinetic profile, the peptide was conjugated with polyethylene glycol (PEG), a non-toxic, non-immunogenic and FDA-approved polymer. Different strategies of pegylation have been considered to find the best method in terms of chemical yield and of maintenance of biological activity. Pegylation via a thioether ligation resulted the best strategy to obtain a slow active peptide release in human blood components with a reduced renal clearance and an increased bioavailability of Bac7(1-35), as biodistribution analyses demonstrated. Several important pathogens, such as S. enterica, cause disease by surviving and replicating within host cells. Since many AMPs have also immunomodulatory activities, we investigated the effect of Bac7(1-35) on the interaction between macrophages and Salmonella. We carried out phagocytosis assays with macrophages and the results suggest that Bac7(1-35) plays a positive modulatory effect on this function. Phagocytosis assays were also performed to determine if Bac7(1-35) could inhibit survival and replication of intracellular Salmonella. The results show that the peptide inhibits the replication of intracellular Salmonella, suggesting that it can exert its antibacterial activity within eukaryotic cells. Further studies are required to fully understand the details of the Bac7(1-35) biological activities. The results obtained provide encouraging evidence for future investigations on Bac7(1-35) and on the pegylated form Bac7(1-35)CAM-PEG20k also in other models of infection and with different intracellular pathogens.
XXIII Ciclo
1981
Runti, Giulia. "New insights into the architecture and function of SbmA, an unusual transporter of the inner membrane of E. coli." Doctoral thesis, Università degli studi di Trieste, 2012. http://hdl.handle.net/10077/7409.
Повний текст джерелаSbmA/BacA è una proteina della membrana interna presente nei batteri Gram negativi e caratterizzata da omologia di sequenza con i domini transmembrana (TMDs) dei sistemi di trasporto di tipo ABC. Ceppi di E. coli con una delezione completa del gene sbmA mostrano un’aumentata resistenza al peptide antimicrobico Bac7 e ad altri peptidi ricchi in prolina a seguito di una loro ridotta internalizzazione. Gli omologhi di SbmA in altre specie sono essenziali per instaurare un’infezione cronica sia in ospiti di origine vegetale che animale. Lo scopo del presente lavoro è stato caratterizzare l’organizzazione e la funzione del sistema di trasporto rappresentato da SbmA in E. coli. Mediante saggi di cromatografia di affinità e di anisotropia a fluorescenza, è stato mostrato come SbmA sia in grado di legare Bac7 senza la necessità di una proteina di legame del substrato (SBP). Inoltre, mediante la tecnica del doppio ibrido in batterio e saggi di crosslinking in vitro, è stato mostrato come SbmA formi dimeri sia in vivo sia in vitro. Saggi di citofluorimetria in presenza di diversi inibitori metabolici indicano come la presenza di un gradiente protonico sia essenziale per garantire il trasporto del peptide attraverso la membrana batterica, trasporto che sembra essere indipendente dall’energia derivata dall’idrolisi dell’ATP. Allo scopo di identificare possibili interattori di SbmA, è stato analizzato il locus genomico di sbmA ed è stato dimostrato che il gene yaiW, localizzato a valle di sbmA, forma con quest’ultimo un’unica unità trascrizionale. Sebbene i due geni siano cotrascritti, le corrispondenti proteine non sembrano interagire né a livello citoplasmatico né di membrana interna. Tuttavia, l’interazione tra queste due proteine a livello periplasmico non può essere esclusa ed il coinvolgimento di YaiW nell’internalizzazione di Bac7 mediata da SbmA può essere ipotizzato sulla base dell’aumentata resistenza al peptide mostrata dal ceppo con una delezione completa del gene yaiW. Dal vaglio in vivo dell’intero proteoma di E. coli versus SbmA mediante il sistema BACTH non è stato identificato alcun dominio di legame dell’ATP, rafforzando quindi l’ipotesi che il sistema di trasporto rappresentato da SbmA non richieda l’idrolisi dell’ATP come fonte di energia. Questo studio ha permesso di identificare 9 possibili interattori di SbmA, tra i quali la proteina della membrana interna FieF, coinvolta nell’efflusso di ioni Zn(II) dalla cellula batterica. E’ stato mostrato come FieF sia coinvolta nell’internalizzazione di Bac7 mediata da SbmA e come l’espressione di sbmA sia modulata dagli ioni Zn(II) in maniera complessa, suggerendo un possibile ruolo per questa proteina nella risposta allo stress da parte del batterio. Questi risultati suggeriscono come SbmA sia un insolito trasportatore di peptidi derivato dalla famiglia dei trasportatori ABC, che ha successivamente perso e/o cambiato nel corso dell’evoluzione alcune caratteristiche, come ad esempio la necessità di una proteina di legame del substrato o la fonte di energia richiesta per il trasporto dei substrati. Inoltre, l’interazione osservata tra le due proteine SbmA e FieF potrebbe suggerire un possibile ruolo della prima nel processo di detossificazione dello zinco, attività che potrebbe essere modulata dal legame di un substrato di natura peptidica a SbmA. Infine, la regolazione dell’espressione di sbmA mediata dagli ioni Zn(II) potrebbe avere un ruolo fisiologico nell’ospite in quanto promuove una maggiore suscettibilità dei batteri ai peptidi antimicrobici ed è in grado di attivare effettori cellulari come i neutrofili.
SbmA/BacA is a protein of the inner membrane of many Gram negative bacteria, predicted to be the transmembrane domain of an ABC transport system. sbmA-deleted E. coli strain shows an increased resistance to the antimicrobial peptide Bac7 and other proline-rich peptides due to their reduced uptake. In addition, BacA of some Gram negative species is essential to establish chronic infection in animal and plant hosts. The aim of this study was to characterize the architecture and function of the SbmA transport system in E. coli. By affinity chromatography and fluorescence anisotropy assays we showed that SbmA is able to bind Bac7 also without the requirement of a substrate-binding protein. By using a bacterial two-hybrid BACTH system and in vitro crosslinking assay we showed that SbmA forms dimers both in vivo and in vitro. Flow cytometry analysis using different metabolic inhibitors indicate that the proton motive force rather than ATP hydrolysis may represent the driving force for the translocation of peptide substrates. Searching for possible interactors of SbmA, we showed that the yaiW gene, located downstream of sbmA, is part of the same operon. Even if the two genes are cotranscribed, the corresponding proteins do not seem to interact neither at the cytoplasmic nor at the inner membrane level. However, ΔyaiW strain showed an increased resistance to Bac7 suggesting the involvement of this protein in the SbmA-mediated uptake of the peptide. An in vivo screening of the whole proteome of E. coli against SbmA by the BACTH system did not identify any nucleotide-binding domain of the transporter, strengthening the hypothesis that the transport system is energized by a mechanism different from ATP hydrolysis. Two-hybrid analysis allowed us to fish out 9 potential interactors and among those our attention was focused on FieF, an inner membrane protein involved in zinc efflux from the bacterial cell. We demonstrated that FieF is involved in the SbmA-mediated uptake of Bac7 and that the expression of sbmA is modulated by zinc ions in a complex manner, suggesting a stress role for this protein in bacteria. Overall, these findings suggest that SbmA is an unusual peptide transporter likely derived from the widespread ABC transporters, which has evolutionary lost/changed some typical features of this transport systems, such as the request of a substrate-binding protein and the ATP binding domain. The interaction between SbmA and FieF points to a possible involvement of the former in zinc detoxification, a function which may be modulated by the binding of an unidentified peptide substrate. The regulation of the expression of SbmA by zinc ions might have a physiological relevance in the host because it makes the target bacteria more susceptible to the AMPs and activates cellular effectors such as the neutrophils.
XXIV Ciclo
1984
Mawson, Mark. "Interactive fluid-structure interaction with many-core accelerators." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/interactive-fluidstructure-interaction-with-manycore-accelerators(a4fc2068-bac7-4511-960d-41d2560a0ea1).html.
Повний текст джерелаSaunders, Catherine. "Asymptotic methods applied to problems of steady-streaming flows and acoustic radiation forces." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/asymptotic-methods-applied-to-problems-of-steadystreaming-flows-and-acoustic-radiation-forces(7c4856bd-5d9d-44b5-bac7-d2aed745f258).html.
Повний текст джерелаGray, Imara. "Self-esteem and self-concept in individuals with 'poor me' and 'bad me' persecutory beliefs." Thesis, Bangor University, 2009. https://research.bangor.ac.uk/portal/en/theses/selfesteem-and-selfconcept-in-individuals-with-poor-me-and-bad-me-persecutory-beliefs(60be59cb-0d54-4275-bac7-823bea6cf811).html.
Повний текст джерелаLindberg, Erik, and Lukas Magnusson. "WEC Back-to-back Topology." Thesis, Uppsala universitet, Institutionen för teknikvetenskaper, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-351912.
Повний текст джерелаJohnson, Lisa Marie. "Back to back they faced each other." Thesis, University of Iowa, 2011. https://ir.uiowa.edu/etd/993.
Повний текст джерелаFluhrer, Regina. "Zwei neuartige Aspartylproteasen BACE-1 und BACE-2." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-14423.
Повний текст джерелаTan, Jiak-San. "Flexibility in MLVR-VSC back-to-back link." Thesis, University of Canterbury. Electrical and Computer Engineering, 2006. http://hdl.handle.net/10092/1119.
Повний текст джерелаViteri, Villanueva Wálter, Rosalino Vicente Rojas, Cobos Alejandro Vásquez, Wong Eduardo William Tam, and Padilla Daniel Osores. "Edificio Bach." Universidad Peruana de Ciencias Aplicadas - UPC. Escuela de Postgrado, 2009. http://hdl.handle.net/10757/273994.
Повний текст джерелаFilho, Roberto Panucci. "Lease-back." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/2/2131/tde-11022015-080815/.
Повний текст джерелаThis dissertation analyzes lease-back agreements under Brazilian law. Lease-back is a type of finance lease (arrendamento mercantil financeiro) wherein the seller of the asset and the lessee are the same legal entity. Since 1930s economic, political and legal theories have debated the importance of ownership and control in capitalism and nowadays it is commonly accepted that companies do not need to retain ownership of their assets to develop their business. In this context, lease-back transactions can be used by companies as an alternative source of financing, by disposing of the ownership of their assets without losing the right to use them. The focus of this dissertation is to analyze (i) what is a leaseback agreement; (ii) the elements of lease-back agreements; and (iii) the legality of leaseback agreements under Brazilian law especially in view of potential violation to rules prohibiting pactum commissorium in agreements involving in rem security interests (pledge, mortgage and antichresis) or chattel mortgage (alienação fiduciária em garantia).
Bäck, Leif. "The use of radiofrequency thermal ablation for the treatment of upper airway disorders." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/back/.
Повний текст джерелаFillet, Castella Sergi. "Reducció del mode comú en convertidors Back-2-Back." Doctoral thesis, Universitat Politècnica de Catalunya, 2014. http://hdl.handle.net/10803/279366.
Повний текст джерелаEl present treball aborda l'estudi dels convertidors Back-2-Back, amb especial èmfasi en els seus efectes sobre el mode comú. Per l'estudi es realitza una revisió de les diferents causes conegudes dels corrents pels coixinets, així com del mode comú aportat pels diferents mètodes de modulació, tant en VSIs com en convertidors B2B. S'estudien diversos mètodes de modulació originals que permeten reduccions importants en el mode comú aportat, i per tant, en la vida dels accionaments i càrregues. Per finalitzar, s'estudien determinades aportacions també originals que permeten aprofitar el mode comú per a obtenir efectes beneficiosos quan l'aplicació del mateix no ens causa preocupació
Blaauwbroek, Nikki [Verfasser], Wolfgang [Akademischer Betreuer] [Gutachter] Bach, and Frank [Gutachter] Lisker. "Geochemical models of Sb(-As,Au,Ag) mineralization in the Archaean and modern hydrothermal settings : Examples from the Murchison Greenstone Belt and the Manus back-arc basin / Nikki Blaauwbroek ; Gutachter: Wolfgang Bach, Frank Lisker ; Betreuer: Wolfgang Bach." Bremen : Staats- und Universitätsbibliothek Bremen, 2017. http://d-nb.info/1123194777/34.
Повний текст джерелаWheeler, Jeremy Nicholas. "Back-to-back converters for variable speed motor drive applications." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294550.
Повний текст джерелаSlebodnik, Mary F. "Back to Bluefield." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3269.
Повний текст джерелаDhliwayo, Mercy. "Bringing us back." Thesis, Rhodes University, 2018. http://hdl.handle.net/10962/63077.
Повний текст джерелаCandy, Elizabeth A. "Adolescent back pain." Thesis, University of East Anglia, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492968.
Повний текст джерелаChentowa, Sofia. "Bach und Schostakowitsch." Musikgeschichte in Mittel- und Osteuropa ; 5 (1999), S. 85-98, 1999. https://ul.qucosa.de/id/qucosa%3A15627.
Повний текст джерелаBudde, Elmar. "Webern und Bach." Bärenreiter Verlag, 1987. https://slub.qucosa.de/id/qucosa%3A37209.
Повний текст джерелаMota, André Freire. "Departamento "back office"." Master's thesis, FEUC, 2016. http://hdl.handle.net/10316/32503.
Повний текст джерелаO presente trabalho visa demonstrar a experiência obtida ao longo de dezanove semanas, no departamento do “Back office” Financeiro da empresa Visabeira Pro – Estudos e Investimentos, no âmbito da conclusão dos estudos no Mestrado em Gestão, pela Faculdade de Economia da Universidade de Coimbra. Neste relatório serão descritas as tarefas realizadas ao longo do período de estágio nomeadamente conferência de saldo inter-grupo, confirmação de contas correntes, saldos dos fornecedores, saldos dos clientes, confronto de saldos em diferentes programas, análise de saldos antigos e extratos bancários, assim como a importância das mesmas na atividade da empresa e a utilização do software necessário para efetuar o trabalho. Por ter feito parte do departamento do “back office” e mediante as tarefas realizadas, a revisão da literatura deste relatório centrar-se-á sobretudo em quatro ideias chaves, o back office, interações existentes, a tecnologia e por fim a globalização. A partir destas, procurar-se-á aprofundar os conhecimentos transmitidos, pelo departamento do “back office” ao estágiario, percebendo o impacto que cada uma tem sobre a outra, assim como as relações que têm sido desenvolvidas ao longo dos tempos.
Candela, Nicholas. "Beating Back Babylon." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2347.
Повний текст джерелаChentowa, Sofia. "Bach und Schostakowitsch." Universitätsbibliothek Leipzig, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-224605.
Повний текст джерелаKempen, Suzanne van. "Bach - musikpädagogisch betrachtet." Frankfurt, M. Berlin Bern Bruxelles New York, NY Oxford Wien Lang, 2008. http://d-nb.info/996278222/04.
Повний текст джерелаFundakubi, Zukile Anthony. "Back to nowhere." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/5071.
Повний текст джерелаLe ngqokelela yamabali iqulathe amabali angobomi babantu abasezilokishini nabo bahlala ezilalini. Nangona umfundi angahle awafumanisa ehlekisa amanye elusizi, injongo yombhali asikukuhlekisa nakunyanzelisa imfundiso koko ikuzoba ubomi bababantu, bephila kwezi ndawo neengxaki abajongene nazo. Imeko yaba bantu kumakhaya ngamakhaya yiyo ebangele ukuba umbhali abelane nomfundi ngokuqhubekayo ebomini.
This thesis is presented in two parts: English and isiXhosa.
Helen, Maureen. "The back flats." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2002. https://ro.ecu.edu.au/theses/851.
Повний текст джерелаShojaei, Iman. "LOWER BACK BIOMECHANICS AT NON-CHRONIC STAGE OF LOW BACK PAIN." UKnowledge, 2018. https://uknowledge.uky.edu/cbme_etds/52.
Повний текст джерелаHöjer, Tomas. "Grant back-klausuler i tekniköverföringsförordningen." Thesis, Uppsala universitet, Juridiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233293.
Повний текст джерелаLinsley, Dennis Edward. "Melodic inversion in J. S. Bach's keyboard suites / by Dennis Edward Linsley." Connect to title online (Scholars' Bank), 2008. http://hdl.handle.net/1794/7770.
Повний текст джерелаChung, Erin H. "The Well-tempered clavier by J.S. Bach : a performance guide to twelve selected preludes and fugues arranged in order of ascending difficulty /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/11280.
Повний текст джерелаMahony, Christopher. "International crimes prosecution case selection : the ICC, ICTR, and SCSL." Thesis, University of Oxford, 2013. https://ora.ox.ac.uk/objects/uuid:a390aead-46cb-42bb-baa7-431540692d9d.
Повний текст джерелаFry, Andrew E. "Genome mapping of malaria resistance genes : the host ligands of PfEMP1." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:df1ffe4b-ba67-4fc6-9024-b278b887d4f9.
Повний текст джерелаMoore, Katie Louise. "High resolution secondary ion mass spectrometry analysis of trace elements in cereal grain and roots." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:ab4f4a19-baca-48a7-af54-b9c5d87f3b7a.
Повний текст джерелаPaksoy, H. B. "Alpamysh." Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:d83d772b-baca-4336-bff6-2cf0d1c096a6.
Повний текст джерелаHeley, Jesse. "Rurality, class, aspiration and the emergence of the 'New Squierarchy'." Thesis, Aberystwyth University, 2008. http://hdl.handle.net/2160/157bb0ca-63ba-44cc-ba87-b260990d05d1.
Повний текст джерелаKeogh, Mary. "Energy and regional power in advanced developing states : a Turkish case study." Thesis, Aberystwyth University, 2018. http://hdl.handle.net/2160/cbafba78-fa5c-4993-ba17-fa1f460dc276.
Повний текст джерелаLane, Tyler J. "Health and responsibility : the relationship between parental illness and children's work in South Africa." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:d5e4439b-bac8-45fb-a124-cf3e43d65a3a.
Повний текст джерелаLiang, Kun. "A novel linear electromagnetic-drive oil-free refrigeration compressor." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:a6b61f49-895d-4587-baa7-91d5d1feff14.
Повний текст джерелаNnoaham, Kelechi Ebere. "A multi-centre study of the impact of endometriosis on health-related quality of life and work productivity." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:b514d4e4-f001-4f73-ba57-72f69d742c64.
Повний текст джерелаBilton, Matthew. "Activation of MAIT cells, and their role in Mycobacterium tuberculosis infection." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:f6838397-c300-4d00-bac6-60914bc5a69c.
Повний текст джерелаVaughan, Nancy. "Partitioning of foraging habitat resources among bats (Chiroptera) in Great Britain." Thesis, University of Bristol, 1996. http://hdl.handle.net/1983/5dae8611-bacc-4ff5-a3dc-49f7e3d1131f.
Повний текст джерелаCore, Bryony A. "New main group and rare earth ring-opening polymerisation catalysts." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:dc881fbc-bac2-4419-a991-ffc863977701.
Повний текст джерелаKylänpää-Bäck, Marja-Leena. "Acute pancreatitis : diagnosis and assessment of severity with markers of inflammation." Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/kylanpaa-back/.
Повний текст джерелаHiltunen-Back, Eija. "Epidemiology of syphilis, gonorrhoea and chlamydia trachomatis infection in Finland in the 1990s." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/hiltunen-back/.
Повний текст джерелаChaouche, Sabine. "Young men at Oxford (1830-80) : routes into consumption and debt." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:e83c1570-5f6e-41a4-ba57-587ad3ff443f.
Повний текст джерелаSantos, Guilherme Vianna. "Sistemas de controle aplicados a aerogeradores síncronos com conversores Back-to-Back." Universidade Federal de Minas Gerais, 2015. http://hdl.handle.net/1843/BUBD-A3HGQF.
Повний текст джерелаO trabalho de dissertação apresenta as principais conceitos do sistema de geração eólica e a tecnologia de aerogerador baseada no geradores síncronos conectados á rede elétrica através de um conversor Back-to-Back. Uma modelagem matemática dos principais componentes do sistema de geração é desenvolvida neste trabalho assim como o projeto dos controladores utilizados para comandar o sistema. O sistema de geração eólica proposto é construído em laboratório assim como a nova plataforma de controle baseado em uma hardware de ponto utuante para permitir a realização de teste experimentais. A turbina eólica é representada por um motor de indução mecanicamente acoplado ao gerador síncrono. Neste trabalho são utilizadas técnicas de controle clássicas do tipo PI no referencial síncrono e n~ao-linear baseado em passividade. Um estudo téorico sobre as leis de controle Interconnection and Damping Assignment Passivity-based Control IDA-PBC no contexto da aplicação é realizado e o projeto dos controlador é apresentado e a in u^encia dos parâmetros do controlador IDA-PBC é discutida. Técnicas de rastreamento de máxima potência do gerador eólico são desenvolvidas para o sistema simulado e prático. Por m os resultados simulados e experimentais para o sistema desenvolvido são apresentados e discutidos.
Crespo, Herrera Tedy Alain. "Control de orden fraccionario pi en convertidores de potencia back-to-back." Tesis, Universidad de Chile, 2017. http://repositorio.uchile.cl/handle/2250/146594.
Повний текст джерелаEn esta Tesis se presenta el uso de un control fraccionario proporcional-integral (FOPI) para convertidores de potencia, el cual es comparado con un control de orden entero proporcional-integral (PI), utilizado dentro del algoritmo de control vectorial, aplicadas a generadores síncronos de imanes permanentes (GSIP), operando con una red a frecuencia constante, interconectados mediante dos convertidores de potencia en una topología Back-To-Back (BTB). La idea de esta estrategia es transformar corrientes y voltajes en un marco de referencia giratorio (dq), donde las corrientes controladas son constantes en estado estacionario y posteriormente transformar las salidas de los controladores (FOPI y PI) en marco de referencia fijo (αβ) entregadas a un algoritmo de Modulación de Espacio Vectorial (SVM) que se encarga de generar los ciclos de trabajo necesarios para la conmutación de los elementos semiconductores que conforman los convertidores. El control del convertidor del lado GSIP tiene como objetivo principal el control de velocidad de la maquina eléctrica, mientras que el convertidor en lado de la red es, mantener el nivel de voltaje en el enlace de corriente continua (Dc-Link) que interconecta ambos convertidores. El sistema de control es tratado en el contexto de recuperación de energía en un mineroducto, pensado en que el sistema de control pueda tener la capacidad de realizar el mismo trabajo de las estaciones de choque, encargadas de mantener la velocidad de la pulpa mineral que transporta, sin embargo con este tipo de sistemas propuesto se podría recuperar parte del potencial energético disponible en el sistema y, emplearla de alguna manera más eficiente, proponiendo en este trabajo que sea conectada a una red eléctrica, buscando de esta manera que el sistema propuesto pueda ser una alternativa que cumpla la función de las estaciones disipadoras y además la recuperación de energía, aprovechando las ventajas de los controladores de orden fraccionario. Cabe mencionar que en este documento solo trata lo correspondiente a la parte de control del sistema eléctrico. El estudio de comparación se realiza a nivel de simulación mediante el uso de programas computacionales Matlab-Simulink y Plecs, para los sistemas de control y los sistemas eléctricos respectivamente. Para determinar los escenarios de simulación del sistema se toma en cuenta los posibles escenarios que pueda presentarse en el mineroducto, siendo estos, una prueba sin posibles cambios en el torque de entrada, dos más cuando sufre cambios de +15% y -15% de la entrada nominal, una más cuando la entrada del sistema se torna de forma oscilante entre ±15%, en la última de las simulaciones se realizan combinación de controladores FOPI y PI dentro del algoritmo de control.
au, S. Tampalini@murdoch edu, and Sergio Tampalini. "Affective space (looking back)." Murdoch University, 2006. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20071116.144247.
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