Добірка наукової літератури з теми "Axe microbiote-Intestin-Cerveau"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Зміст
Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Axe microbiote-Intestin-Cerveau".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Статті в журналах з теми "Axe microbiote-Intestin-Cerveau"
Piguet, P. "L’axe intestin–cerveau : les pistes actuelles." Douleur et Analgésie 34, no. 2 (June 2021): 70–85. http://dx.doi.org/10.3166/dea-2021-0167.
Повний текст джерелаRabot, Sylvie. "Axe intestin-cerveau : comment le microbiote intestinal influence la réponse au stress." Bulletin de l'Académie Vétérinaire de France, no. 3 (2015): 267. http://dx.doi.org/10.4267/2042/57938.
Повний текст джерелаДисертації з теми "Axe microbiote-Intestin-Cerveau"
Jaglin, Mathilde. "Axe intestin-cerveau : effets de la production d'indole par le microbiote intestinal sur le système nerveux central." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-01057811.
Повний текст джерелаJaglin, Mathilde. "Axe intestin-cerveau : effets de la production d’indole par le microbiote intestinal sur le système nerveux central." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112312/document.
Повний текст джерелаThe gastro-intestinal tract hosts a complex microbial community, the gut microbiota, whose collective genome coding capacity vastly exceeds that of the host genome. The involvement of the gut microbiota in various aspects of the host physiology, such as the nutritional metabolism and the immunity, has long been studied. In contrast, the possible action of the gut microbiota on brain development and functioning is a new line of research, still poorly explored. In this context, we performed a first general study of the effect of gut microbiota on the brain by comparing the sensory-motor functions, the anxiety-like behaviour, the activation of the hypothalamic-pituitary-adrenal axis and the brain monoamine profile in germ-free and conventional F344 rats. The results show that, in this particularly stress-sensitive strain, absence of gut microbiota exacerbates the anxiety-like behaviour and neuroendocrine response to stress, and reduces brain dopamine metabolism. To investigate the means by which the microbiota can affect the brain, a second study was conducted, targeting a specific bacterial metabolite, indole, whose oxidative derivatives, produced by the liver, are known to have neuroactive properties. Indole is a natural metabolite of the gut microbiota, whoseoverproduction could occur during a microbiota dysbiosis. Two conditions of overproduction, namely chronic and acute, were modelled. In both cases, significant changes in the behaviour of the host were observed. In chronic overproduction, indole promotes anxiety- and depressive-like behaviours, while acute overproduction has a marked sedative effect. From a mechanistic point of view, we confirm that indole can act on the central nervous system through its oxidized derivatives and show for the first time that it can also act by activating the brain nuclei of the vagus nerve
Charton, Elise. "Lait humain vs. préparation pour nourrissons : digestibilité des protéines et impact sur l’axe microbiote-intestin-cerveau." Electronic Thesis or Diss., Rennes, Agrocampus Ouest, 2023. http://www.theses.fr/2023NSARB368.
Повний текст джерелаNowadays, a high rate of infants is still being fed infant formulas (IF) based on cow milk and subjected to several technological treatments. These substitutes aim to mimic as close as possible the human milk (HM). Despite of IF improvement, differences still exist between HM and IF in terms of composition and structure, and effects on health in infancy, and later on in adulthood. The objective of this work was to understand how the infant food modulated the dietary nitrogen digestibility and, in overall, how it shaped the microbiota-gut-brain axis. Two infant models were used and compared, the 16 to 21-day-old mini-piglet Yucatan and an in vitro dynamic digestion model parametered with term infant digestive conditions. Digestive contents and tissues were then analyzed using metagenomic (microbiota), histological and ex vivo permeability (intestinal physiology) approaches, gene expression and targeted-metabolomic approaches (intestine, brain and plasma). The results showed that the digestibility of nitrogen and at least extent, that of a few amino acids (Lys, Phe, Thr, Val, Ala, Pro and Ser) were different between HM and IF. The two digestion models (in vivo and in vitro) led to similar observations in terms of meal deconstruction and proteolysis, showing that the in vitro dynamic digestion model is a good proxy of the in vivo digestion regarding digestion kinetics. The microbiota-gut-brain axis, notably regarding the colonic microbial composition and the tryptophan metabolism, which digestibility was similar between infant foods, were differently modulated by HM and IF. The increase of the intestinal permeability, though moderately, was associated with a boost of the intestinal immune system and changes in gene expression (barrier and endocrine functions, volatile fatty acids receptors) at hypothalamic and striatal levels and with changes in hippocampal and plasma metabolomic profiles. Some components present in HM (e.g.: oligosaccharides, non-protein nitrogen such as urea, bacteria consortia) and absent in IF can explain the discrepancies observed. IF-supplementation with these bioactive components and/or with the modulation of the protein profile would be of interest for further investigation
Gabriel, Tristan. "Rôle du système immunitaire intestinal au sein de l’axe microbiote-intestin-cerveau dans les symptômes psycho-comportementaux." Electronic Thesis or Diss., Saint-Etienne, 2023. http://www.theses.fr/2023STET0035.
Повний текст джерелаGrowing knowledge of the association between microbiota and immune system abnormalities in patients with psychiatric disorders makes the microbiota-gut-brain axis an indispensable player to study. This thesis aims to explore the role of the intestinal immune system in psychobehavioral diseases. The first objective of characterizing the intestinal mucosal immune system was achieved through a clinical study of female patients suffering from anorexia. A surprising absence of inflammatory markers and a higher frequency of circulating regulatory T lymphocytes were demonstrated. Our second objective was to study the impact of microbiota on behavior. The fecal microbiota of patients with severe anorexia nervosa has been shown to cause inflammation in animals and abnormalities in test anxiety behavior. We initiated a microarray project linking immune cells and neurons to study inflammatory signal transduction, constituting the first proof-of-concept for modeling the in vitro neural pathway of the microbiota-gut-brain axis. Our third objective was to characterize the psycho behavioral effects of immuno-pathological phenomena in chronic inflammatory bowel disease. They identify a very high prevalence of the symptom abulia in patients experiencing persistent fatigue. However, quiescent bowel disease indicates abnormalities in brain structures involved in positive valence (motivation) domains. These elements have been studied in an animal model of inflammatory colitis induced by DSS, whose behavioral study still needs to be improved. These elements support the hypothesis that the microbiota and the intestinal immune system are strongly implicated as a unit capable of pathologically modifying cerebral functioning and translating into psycho-behavioral effects in subjects. The richness of the microbiota-gut-brain axis raises hopes of a revolution in psychiatry regarding diagnosis, prognosis, and treatment
De, Vadder Filipe. "Détection portale des nutriments et contrôle de l'homéostasie énergétique par l'axe nerveux intestin-cerveau." Phd thesis, Université Claude Bernard - Lyon I, 2014. http://tel.archives-ouvertes.fr/tel-01058661.
Повний текст джерела