Дисертації з теми "Automated cell to signal"
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Taylor, Harriet Beverly. "Functional analysis of zebrafish innate immune responses to inflammatory signals." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4825.
Повний текст джерелаO'Neill, Kieran. "Automated analysis of single cell leukemia data." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50867.
Повний текст джерелаScience, Faculty of
Graduate
Martin, Bailey-Van Kuren Michael. "Automated cell supervisory control for product disassembly." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/20158.
Повний текст джерелаBalraj, Navaneethakrishnan. "AUTOMATED ACCIDENT DETECTION IN INTERSECTIONS VIA DIGITAL AUDIO SIGNAL PROCESSING." MSSTATE, 2003. http://sun.library.msstate.edu/ETD-db/theses/available/etd-10212003-102715/.
Повний текст джерелаSameeuddin, Sameeuddin. "Automated Ultrasonic Signal Classification of Carbon Fiber Reinforced Plastic Laminates." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/theses/1497.
Повний текст джерелаBala, Divya Chandrakant. "Cell Phenotype Analyzer: Automated Techniques for Cell Phenotyping using Contactless Dielectrophoresis." Thesis, Virginia Tech, 2016. http://hdl.handle.net/10919/71428.
Повний текст джерелаMaster of Science
Sundström, Magnus. "Signal Transduction in Mast Cell Migration." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1474.
Повний текст джерелаMast cells are essential effector cells in the immune system as they release several inflammatory mediators. An accumulation of mast cells has been described in inflammatory conditions such as asthma and allergic rhinitis. Increased mast cell number, in the skin and other organs, is also a characteristic in mastocytosis, a disease without an effective treatment. One explanation for the increase in mast cell number is migration of mast cells in the tissue. In our studies we utilised mast cell lines, including HMC-1; cell lines transfected with the c-kit gene; and in vitro developed mast cells.
Our aim was to characterise, two variants of the HMC-1 cell line; the signalling pathways essential for mast cell migration towards TGF-β and SCF; and the mechanism regulating mast cell accumulation in mastocytosis.
Our results help to explain inconsistent findings regarding mast cell biology when HMC-1 cells have been used as a model system. The two variants, which we name HMC-1560 and HMC-1560, 816, are used in different laboratories around the world. HMC-1560 and HMC-1560, 816 exhibited different characteristics regarding their karyotype, phenotype as well as their set of activating point mutations in the Kit receptor. Furthermore, divergent signalling pathways are of importance for mast cell migration towards TGF-β and SCF. The classical MAP kinase-signalling cascade was found to be of major relevance for TGF-β-induced migration. In contrast, this pathway had a modest impact on SCF-induced migration, which instead was highly dependent on p38 MAP kinase signalling. Finally, one mechanism for mast cell accumulation in mastocytosis appeared to be an activating point mutation in the gene for the Kit receptor. This mutation appeared to prone transfected cells and mast cell progenitors to a higher rate of migration towards SCF if compared with cells expressing wt Kit receptor.
In conclusion, our results show the importance of two different MAP kinase signalling pathways and mutations in the Kit receptor for mast cell migration induced by various types of stimuli. This knowledge helps us to understand the mechanism
Lennartsson, Johan. "Stem Cell Factor Induced Signal Transduction." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5291-4/.
Повний текст джерелаSundström, Magnus. "Signal transduction in mast cell migration /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5130-6/.
Повний текст джерелаZou, Rui Ghosh Avijit. "Automated sensitivity analysis on spatio-temporal biochemical systems /." Philadelphia, Pa. : Drexel University, 2007. http://hdl.handle.net/1860/1565.
Повний текст джерелаMagnusson, Klas. "Cell tracking for automated analysis of timelapse microscopy." Thesis, KTH, Signalbehandling, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-53772.
Повний текст джерелаFernyhough, Emma Nicole. "Automated segmentation of structures essential to cell movement." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/13484/.
Повний текст джерелаRazban, Ali. "Intelligent control of an automated adhesive dispensing cell." Thesis, Imperial College London, 1993. http://hdl.handle.net/10044/1/7246.
Повний текст джерелаGuo, Shuman. "A Novel Method for Automated Cell Image Selection." Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/math_theses/119.
Повний текст джерелаLambert, Russell. "Signal processing and shielding of ultrasonic echoes for automated welding control." Thesis, Georgia Institute of Technology, 1987. http://hdl.handle.net/1853/16000.
Повний текст джерелаMcAllister, Christine Joan. "Automated design of high performance digital filter chips." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318797.
Повний текст джерелаValdimarsdóttir, Gudrun. "TGFβ Signal Transduction in Endothelial Cells". Doctoral thesis, Uppsala University, Ludwig Institute for Cancer Research, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4284.
Повний текст джерелаTransforming growth factor β (TGFβ) is a multifunctional cytokine that is involved in many biological effects, such as proliferation, migration, differentiation and cell survival. TGFβ regulates cellular responses by binding to a heteromeric complex of type I and type II serine/threonine kinase receptors. The type I receptor, termed activin receptor-like kinase (ALK), acts downstream of the type II receptor and propagates the signal to the nucleus by phosphorylating receptor regulated Smads (R-Smads). The activated R-Smads can associate with the common partner Smad, Smad4, and this complex translocates to the nucleus where it participates in transcriptional regulation of target genes. TGFβ plays an important role in vascular morphogenesis. The aim of this study was to obtain more insight into the mechanisms by which TGFβ can act as an inhibitor or stimulator of angiogenesis Our findings show that in endothelial cells (ECs), TGFβ can activate two distinct type I receptor/Smad signalling pathways with opposite cellular responses. In most cell types, TGFβ signals via the TGFβ type I receptor, ALK5. However, ECs express a predominant endothelial type I receptor, named ALK1. Whereas the TGFβ/ALK1 signalling leads to activation, the TGFβ/ALK5 pathway results in an inhibition of the activation state. This suggests that TGFβ regulates the activation state of the endothelium via a fine balance between these two pathways. We identified genes that are specifically induced by TGFβ mediated ALK1 or ALK5 activation. Id1 was found to be the target gene of the ALK1/Smad1/5 pathway while induction of plasminogen activator inhibitor-1 was activated only by ALK5/Smad2 pathway. Furthermore, ALK1 activated ECs are highly invasive but this property is lost if Id1 expression is specifically knocked-down. ECs invasiveness is highly dependent on αv integrin binding to its extracellular matrix (ECM) protein partner and the invasion requires proteolytic cleavage of the ECM by metalloproteases (MMPs). Hence, TGFβ/ALK1/Id1 pathway may promote invasion by modulating the expression or activity of integrins and MMPs that are well known components of the ECM. Timing and duration of TGFβ signalling are important specificity determinants for its effect on cellular behaviour. After binding to ALK1, TGFβ induces a transient phosphorylation of Smad1/5 but a stable phosphorylation of Smad2 via ALK5. Our studies indicate that Smad7 is potently induced by ALK1 signalling and may recruit a PP1α/TIMAP phosphatase complex to ALK1 to dephosphorylate the receptor and thereby turning off phosphorylation resulting in a temporal activation of TGFβ/ALK1-induced Smad1/5 pathway. This mechanism enables an efficient and tightly temporally controlled activation resulting in the dominance of ALK5 upon prolonged exposure to TGFβ. Bone morphogenetic protein (BMP) is a member of the TGFβ superfamily and signals through Smad1/5. The BMP/Smad1/5 pathway was found to potently activate the endothelium. Id1 was identified as an important BMP target gene in ECs and was sufficient and necessary for BMP-induced EC migration. These studies not only provide new insights into possible molecular mechanisms that underlie activation and quiescence of ECs during physiological angiogenesis but may also explain the vascular phenotypes observed in mice and humans with perturbed TGFβ signalling pathways.
Gong, Yunchen 1965. "Analyses of alternative cell signal transduction pathways." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85552.
Повний текст джерелаIn this thesis, apoptosis of bovine mammary gland epithelial cells was demonstrated to be induced when fibronectin, one of the major components of ECM, was degraded by overexpressed tPA via two potential ways: deprivation of attachment and the effects of fibronectin fragments. Secondly, a mathematical model for EGFR activation of the MAPK cascade, in which alternative pathways exist, was explored and it was found that the Shc-dependent pathway is both redundant and dominant. We hypothesize that the Shc-dependent pathway is important for EGFR to compete with other receptors, which need Shc to transduce cell signals; and this pathway is not aimed to increase the robustness of the EGFR cascade. Finally, for the general importance of alternative pathways to the network topology and robustness, several concepts have been proposed to decompose and quantitatively characterize the networks. We demonstrate that the pathnet score is a better assessment for robustness than the molecular connectivity.
Grundström, Tobias. "Automated Measurements of Liver Fat Using Machine Learning." Thesis, Linköpings universitet, Datorseende, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-151286.
Повний текст джерелаAnsin, Rasmus, and Didrik Lundberg. "Automated Inference of Excitable Cell Models as Hybrid Automata." Thesis, KTH, Skolan för teknikvetenskap (SCI), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-154065.
Повний текст джерелаI denna uppsats undersöker vi från en experimentell synvinkel möjligheter och begränsningar i den nya inlärningsalgoritmen HYCGE för hybridautomater. Som ett exempel på en praktisk tillämpning, studerar vi algoritmens förmåga att lära sig aktionspotentialens beteende i retbara celler, specifikt Hodgkin-Huxleymodellen av en bläckfisks jätteaxon, Luo-Rudymodellen av en ventrikulärcell i marsvin, och Entchevas modell av en ventrikulär cell i nyfödd råtta .Giltigheten och noggrannheten hos algoritmen visualiseras även genom grafiskamedel.
Ait-Boudaoud, Djamel. "Novel cell architectures for systolic signal processing arrays." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334976.
Повний текст джерелаInterdonato, Giovanni. "Signal Processing Aspects of Cell-Free Massive MIMO." Licentiate thesis, Linköpings universitet, Kommunikationssystem, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-151026.
Повний текст джерелаYeroshenko, O. A., and I. V. Prasol. "Automated determination of the parameters electric miographic signalsfor diagnostics and rehabilitation." Thesis, ХНУРЕ, 2018. http://openarchive.nure.ua/handle/document/7609.
Повний текст джерелаStefansson, Anne. "Mechanisms of Integrin Signal Transduction." Doctoral thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8221.
Повний текст джерелаIntegrins are a protein family of cell surface receptors, expressed in all cell types in the human body, except the red blood cells. Besides their importance in mediating physical connections with the surrounding environment, the integrin family members are also vital signalling mediators. They have no intrinsic kinase activity; instead the signals are transduced through conformational changes.
In this thesis, work is presented which is focused on molecular mechanisms of integrin signal transduction. The signal transduction was first studied from a structural point of view, determining the transmembrane domain borders of a few selected integrin family members and ruling out a signalling model involving a “piston-like” movement.
Then, downstream signalling events involved in the beta1 integrin-induced activation of Akt via the PI3kinase family were characterized. Our results identify a novel pathway for PI3K/Akt activation by beta1 integrins, which is independent of focal adhesion kinase (FAK), Src and EGF receptor. Furthermore, both beta1 integrins and EGF receptors induced phosphorylation of Akt at the regulatory sites Thr308 and Ser473, but only EGF receptor stimulation induced tyrosine phosphorylation of Akt.
Finally, signals from beta1 integrins underlying the morphologic changes during cell spreading were studied. A rapid integrin-induced cell spreading dependent on actin polymerisation was observed by using total internal reflection fluorescence (TIRF) microscopy. This integrin-induced actin polymerisation was shown to be dependent on PI3K p110alpha catalytic subunit and to involve the conserved Lys756 in the beta1-integrin membrane proximal part.
Settipalli, Praveen. "AUTOMATED CLASSIFICATION OF POWER QUALITY DISTURBANCES USING SIGNAL PROCESSING TECHNIQUES AND NEURAL NETWORKS." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_theses/430.
Повний текст джерелаRandolph, Tyler W. "Development of automated method of optimizing strength of signal received by laser interferometer." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/29686.
Повний текст джерелаCommittee Chair: Ume, I. Charles; Committee Member: Mayor, J. Rhett; Committee Member: Sadegh, Nader. Part of the SMARTech Electronic Thesis and Dissertation Collection.
Mickey, Katherine Morgan. "Cell-cell interactions and the specification of cell fates during C. elegans embryogenesis /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/5043.
Повний текст джерелаZhang, Hao. "T cell antigen receptor binding and initial signal transduction." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669994.
Повний текст джерелаChoudhuri, Kaushik. "The mechanism of T cell receptor-mediated signal transduction." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433379.
Повний текст джерелаNoble, Jane Mary. "Cell membrane dynamics and signal transduction in human ageing." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324872.
Повний текст джерелаEllison, Cara Jane. "Sphingomyelin as a danger signal in cell-autonomous immunity." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267993.
Повний текст джерелаHumphrey, Peter Saah. "Signal transduction mechanisms for stem cell differentation into cardiomyocytes." Thesis, University of Hertfordshire, 2009. http://hdl.handle.net/2299/3760.
Повний текст джерелаManyam, Venkata Narasimha. "Mixed-signal predistortion for small-cell 5G wireless nodes." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLT015/document.
Повний текст джерелаSmall-cell base stations (picocells and femtocells) handling high bandwidths (> 100 MHz) will play a vital role in realizing the 1000X network capacity objective of the future 5G wireless networks. Power Amplifier (PA) consumes the majority of the base station power, whose linearity comes at the cost of efficiency. With the increase in bandwidths, PA also suffers from increased memory effects. Digital predistortion (DPD) and analog RF predistortion (ARFPD) tries to solve the linearity/efficiency trade-off. In the context of 5G small-cell base stations, the use of conventional predistorters becomes prohibitively power-hungry.Memory polynomial (MP) model is one of the most attractive predistortion models, providing significant performance with very few coefficients. We propose a novel FIR memory polynomial (FIR-MP) model which significantly augments the performance of the conventional memory polynomial predistorter. Simulations with models extracted on ADL5606 which is a 1 W GaAs HBT PA show improvements in adjacent channel leakage ratio (ACLR) of 7.2 dB and 15.6 dB, respectively, for 20 MHz and 80 MHz signals, in comparison with MP predistorter. Digital implementation of the proposed FIR-MP model has been carried out in 28 nm FDSOI CMOS technology. With a fraction of the power and die area of that of the MP a huge improvement in ACLR is attained.An overall estimated power consumption of 9.18 mW and 116.2 mW, respectively, for 20 MHz and 80 MHz signals is obtained.Based on the proposed FIR-MP model a novel low-power mixed-signal approach to linearize RF power amplifiers (PAs) is presented. The digital FIR filter improves the memory correction performance without any bandwidth expansion and the MP predistorter in analog baseband provides superior linearization. MSPD avoids 5X bandwidth requirement for the DAC and reconstruction filters of the transmitter and the power-hungry RF components when compared to DPD and ARFPD, respectively.The impact of various non-idealities is simulated with ADL5606 (1 W GaAs HBT PA) MP PA model using 80 MHz modulated signal to derive the requirements for the integrated circuit implementation. A resolution of 8 bits for the coefficients and a signal path SNR of 60 dB is required to achieve ACLR1 above 45 dBc, with as little as 9 coefficients in the analog domain. Discussion on the potential circuit architectures of subsystems is provided. It results that an analog implementation is feasible. It will be worth in the future to continue the design of this architecture up to a silicon prototype to evaluate its performance and power consumption
Sharma, Saurabh. "Automated pulsed signal reflectometer for time-domain RF-MEMS characterization in the UHF band." abstract and full text PDF (free order & download UNR users only), 2008. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1460777.
Повний текст джерелаSanders, Teresa H. "Multimodal assessment of Parkinson's disease using electrophysiology and automated motor scoring." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51970.
Повний текст джерелаTibbitt, Christopher Andrew. "The role of T cell receptor signal intensity in T helper 17 cell development." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/2885.
Повний текст джерелаBell, Andrea Dorothy Lee. "Insulin and TSH signal transduction pathways in human preadipocytes." Thesis, University of Ottawa (Canada), 2000. http://hdl.handle.net/10393/8646.
Повний текст джерелаD'Souza, Aswin Cletus. "Automated counting of cell bodies using Nissl stained cross-sectional images." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2035.
Повний текст джерелаXia, Dongchun. "An automated image acquisition and analysis system for cell membrane detection." Thesis, Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/17251.
Повний текст джерелаPetrak, David. "Automated, Spatio-Temporally Controlled Cell Microprinting with Polymeric Aqueous Biphasic Systems." University of Akron / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=akron1375364313.
Повний текст джерелаHur, In Ae. "Novel computer vision algorithms for automated cell event detection and analysis." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/2900.
Повний текст джерелаShewinvanakitkul, Prapan. "Automated Detection and Prediction of Sleep Apnea Events." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1486490112558014.
Повний текст джерелаVieira, Elaine. "Signal Transduction of Glucagon Secretion." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6319.
Повний текст джерелаMyjak, Mitchell John. "A two-level reconfigurable cell array for digital signal processing." Online access for everyone, 2004. http://www.dissertations.wsu.edu/Thesis/Spring2004/m%5Fmyjak%5F050504.pdf.
Повний текст джерелаLingelbach, Frank. "Path planning using probabilistic cell decomposition." Licentiate thesis, Stockholm, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-294.
Повний текст джерелаAl-Habaibeh, Amin. "Rapid design of condition monitoring systems for machining operations." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326780.
Повний текст джерелаMachiraju, Naga Kiran. "Semi Automated Bullet GroupAnalysis for Shooting Target Training." Thesis, Blekinge Tekniska Högskola, Institutionen för tillämpad signalbehandling, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-17046.
Повний текст джерелаLioubin, Mario N. "Fms signal transduction, p150S̳h̳i̳p̳ : a signal transduction molecule with inositol 5-phosphatase activity /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/6339.
Повний текст джерелаMachado, Daniel. "Improving automated redshift detection in the low signal-to-noise regime for Large Sky Surveys." Thesis, Paris 11, 2015. http://www.theses.fr/2014PA112427.
Повний текст джерелаSummary: Redshift is the primary measure by which astronomers can map the Universe in the radial direction. In order to test the assumptions of homogeneity and isotropy, accurate redshifts of galaxies are needed, and for a great many of them. Additionally different cosmological models can only be distinguished by careful observations of the large scale structure traced by these galaxies. Large sky surveys are the only mechanism by which redshifts for a large number of galaxies can be obtained. Accurate redshift estimation is additionally required for many other fields of astronomy including but not limited to: weak lensing, studies of dark matter haloes, galaxy morphology studies, chemical evolution studies, photometric calibration, and studies of large scale structure and galaxy clustering.Problems exist in all surveys at the dim limit of observation, which usually corresponds to the higher redshift objects in the survey, where noise becomes problematic. Magnitude or signal-to-noise ratio cuts are often employed in order to eliminate potentially troublesome objects; such a procedure is a blunt tool for separating good redshift candidates from ones likely to be inaccurate.In this thesis we develop an algorithm to tackle redshift estimation of galaxy spectra in the low signal-to-noise regime. The first part of this thesis introduces the concepts of denoising, particularly False Detection Rate denoising, wavelet transforms and redshift estimation algorithms. The second part details how these concepts are united into the Darth Fader (Denoised and Automatic Redshifts THresholded with a FAlse DEtection Rate) algorithm. The final parts of this thesis apply the algorithm both to idealised synthetic data generated from the COSMOS Mock Catalogue, and to a subset of real data from the WiggleZ survey.We show that Darth Fader can operate effectively at low signal-to-noise given an appropriate choice of FDR parameter for denoising, and an appropriate feature-counting criterion. We also show that Darth Fader can remove the continua of spectra effectively at low signal-to-noise for the purposes of redshift estimation by cross-correlation. Additionally we show from tests on spectra from the WiggleZ survey that our algorithm has the ability to process a substantial subset of that data without the need for visual inspection (to which the entire WiggleZ spectral survey has been subjected), and to a high degree of accuracy. We conclude that the Darth Fader algorithm has potential to be used in large-sky survey pipelines, particularly where signal-to-noise is expected to be poor
Homer, Daniel C. "Population Fit Threshold: Fully Automated Signal Map generation for Baseline Correction in NMR-based Metabolomics." Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1271689072.
Повний текст джерела