Дисертації з теми "Atopic dermatitis Treatment Malaysia"
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Devillers, A. C. A. "Diagnostic work-up and treatment of severe and/or refractory atopic dermatitis." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2009. http://hdl.handle.net/1765/14802.
Повний текст джерелаSchmitt, Jochen, Michael Meurer, Uta Schwanebeck, Xina Grählert, and Knut Schäkel. "Treatment Following an Evidence-Based Algorithm versus Individualised Symptom-Oriented Treatment for Atopic Eczema." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135477.
Повний текст джерелаDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
Dalton, Sarah J. "Controlled studies of emollient ointments and creams in the treatment of atopic dermatitis in childhood." Thesis, University of Manchester, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.545915.
Повний текст джерелаChang, Chen J. B. "A hexa-herbal Chinese formula for treatment of atopic dermatitis : phytochemical analysis and selected anti-inflammatory activities." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1560129/.
Повний текст джерелаSchmitt, Jochen, Michael Meurer, Uta Schwanebeck, Xina Grählert, and Knut Schäkel. "Treatment Following an Evidence-Based Algorithm versus Individualised Symptom-Oriented Treatment for Atopic Eczema: A Randomised Controlled Trial." Karger, 2008. https://tud.qucosa.de/id/qucosa%3A27651.
Повний текст джерелаDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Zook, Tiffany Anne Crawford, and Tiffany Anne Crawford Zook. "Development and Evaluation of a Clinical Practice Guideline to Promote Evidence-Based Treatment of Childhood Atopic Dermatitis in Primary Care." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621743.
Повний текст джерелаFinberg, Marike Johanna. "A comparative study for the topical treatment of atopic dermatitis with Aloe ferox and Aloe vera in Balb/c mice." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/40699.
Повний текст джерелаDissertation (MSc)--University of Pretoria, 2013.
gm2014
Pharmacology
unrestricted
Schmitt, Jochen, Elisabeth Heese, Gottfried Wozel, and Michael Meurer. "Effectiveness of Inpatient Treatment on Quality of Life and Clinical Disease Severity in Atopic Dermatitis and Psoriasis Vulgaris – A Prospective Study." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135494.
Повний текст джерелаDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
Schmitt, Jochen, Elisabeth Heese, Gottfried Wozel, and Michael Meurer. "Effectiveness of Inpatient Treatment on Quality of Life and Clinical Disease Severity in Atopic Dermatitis and Psoriasis Vulgaris – A Prospective Study." Karger, 2007. https://tud.qucosa.de/id/qucosa%3A27655.
Повний текст джерелаDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Sturesdotter, Hoppe Torborg. "Skin Barrier Function and mRNA Expression Profiles in Patients with Atopic Dermatitis, Ichthyosis Vulgaris, and X-linked Recessive Ichthyosis : Aetiopathogenic Differences and the Impact of Moisturizing Treatment." Doctoral thesis, Uppsala universitet, Dermatologi och venereologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-192396.
Повний текст джерелаSolomon, Michael William. "Behavioural intervention in atopic dermatitis." Thesis, 2014. http://hdl.handle.net/10210/9600.
Повний текст джерелаThe purpose of this study was to determine whether a behavioural intervention could reduce scratching behaviour in atopic dermatitis. The literature dealing with the psychological aspects, and existing approaches to the treatment of atopic dermatitis and related dermatoses was reviewed. It was hypothesized that if subjects with atopic dermatitis were able to reduce their scratching behaviour they would show a corresponding reduction in size of identified lesions. In order to test these hypotheses, SUbjects with atopic dermatitis participated in a self-control programme lasting between eight and ten weeks. Of the seven subj ects that originally started the programme, four completed it. SUbjects' self-monitoring details reflected changes in scratching behaviour, and a specially designed grid was used to measure changes in lesion size. Inspection of the data showed that two SUbjects eliminated their scratching behaviour and lesions entirely; the other two showed marked reduction. The results of this study indicate that self-control procedures could be usefully applied as adjuncts to the conventional dermatological management of atopic dermatitis.
Melo, Amélia do Céu Vicente Fontes e. "Baricitinib for the treatment of Atopic Dermatitis." Master's thesis, 2021. https://hdl.handle.net/10216/134610.
Повний текст джерелаMelo, Amélia do Céu Vicente Fontes e. "Baricitinib for the treatment of Atopic Dermatitis." Dissertação, 2021. https://hdl.handle.net/10216/134610.
Повний текст джерелаFrey, Matthew. "The treatment of atopic dermatitis (eczema) with traditional Chinese herbs." 2007. http://www.ocomlibrary.org/images/PDF/studentpapers/matthewfrey.pdf.
Повний текст джерелаColes, Nona Diane. "Effectiveness of stress inoculation training in the treatment of atopic dermatitis." Thesis, 1996. http://hdl.handle.net/2429/6019.
Повний текст джерелаOlivier, Yolande. "The effect of a homoeopathic complex on atopic dermatitis in children." Thesis, 2013. http://hdl.handle.net/10210/8324.
Повний текст джерелаAtopic dermatitis (atopic eczema) is a chronic, relapsing, allergic inflammatory skin disease (Hauk, 2008). The prevalence of atopic dermatitis has increased significantly over the past few decades, with highest rates of 45 – 64% occurring amongst preschool children (Butler, 2009), and 40% amongst older children and adults (Manjra, 2005). This increase in prevalence is attributed to environmental factors such as microbial exposure and poor nutrition, which can all lead to atopic dermatitis (Schnopp, 2006). The quality of life of patients suffering from atopic dermatitis and their family members are significantly affected (Manjra, 2005). Atopic dermatitis is characterized by active skin lesions that are red, flaky, dry and itchy and in children commonly occurs in the flexural areas of the body (Fölster-Hols et al., 2007, Schnopp, 2006). Conventional treatment potions for atopic dermatitis are associated with adverse effects in children (Kalicharan et al., 2005). Homoeopathic remedies may offer an alternative option for this condition. This study aimed to assess the effect of a homoeopathic complex consisting of Graphites 6cH, Histaminum 9cH, Psorinum 6cH and Sulphur 6cH, on atopic dermatitis in children. All the participants of the study received the homoeopathic complex. The atopic dermatitis was evaluated using the SCORAD index (Scoring of Atopic Dermatitis) (Appendix F) and the Children’s Dermatology Life Quality Index (CDLQI) (Appendix E). Thirty four participants who met the inclusion and exclusion criteria were recruited to participate in this pre-test – post-test single group study by means of advertisements (Appendix A) placed in and around primary schools in the Gauteng area (with relevant permission given) and in the local newspaper. Participants were also recruited via word of mouth. Once participants were accepted into the study they were allocated into the treatment group which received the homoeopathic complex containing Graphites 6cH, Histaminum 9cH, Psorinum 6cH and Sulphur 6cH. The study was completed over a four week period. The percentage of the area affected, the intensity of the symptoms, the pruritus and the loss of sleep as well as the quality of life of the participants suffering from atopic dermatitis were aspects of the condition evaluated on a weekly basis. The results for the CDLQI showed improvements in the participant’s perception of itching/ pain of the affected area, as well as their quality of sleep. These improvements were shown to have occurred gradually over the study period. There were however no statistically significant changes noted in the mental and emotional quality of life of the participants.
Kalicharan, Gavna A. "The efficacy of a homoeopathic complex in the treatment of atopic eczema." Thesis, 2008. http://hdl.handle.net/10210/925.
Повний текст джерелаDr. M. R. A. Moiloa Dr. D. Naude Dr. C. Hall
Steagall, Rebecca. "A topical herbal wash for the treatment of atopic dermatitis in felines : a pilot study." 2006. http://www.ocomlibrary.org/images/PDF/studentpapers/rebeccasteagall.pdf.
Повний текст джерела"Investigation of Selected Chinese Medicines for the Treatment of Atopic Dermatitis: Biological and Mechanistic Studies." 2016. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292146.
Повний текст джерела在中醫中,特應性皮炎常備表述為四彎風、奶癬,主要由風、濕、熱等相關。常用的中藥主要分為:清熱藥、祛濕藥、祛風藥等,如黃連解毒湯、四心導赤飲、培土清心方等。許多中藥複方和單味中藥對特應性皮炎具有很好的治療效果,但是其中的絕大多數仍然缺少足夠的實驗性證據來證明其有效性,也缺乏相應的治療機制研究。
本研究選取一些具有代表性的複方和單味中藥進行提取,並以NO和肥大細胞脫顆粒為指標,對這些提取物分別進行抗炎和抗過敏篩選,最終確定對黃連解毒湯和白鮮皮具有良好的抗炎、抗過敏作用,並對其進行深入研究。
在質量控制方面,我們運用HLPC技術分別對黃連解毒湯和白鮮皮的乙醇提取物中特徵性成分進行定性、定量分析。梔子苷、小檗堿、黃芩素、漢黃芩素、黃芩苷這5種指標性成分用於黃連解毒湯醇提物的品質控制;梣酮和黃柏酮這個2中指標性成分用於白鮮皮醇提物的品質控制。
在體外抗炎、抗過敏實驗中,我們分別選取了RAW264.6和RBL-2H3細胞作為體外研究模型。黃連解毒湯提取物具有很強體外抗炎作用,能有通過抑制MAPKs和NF-κB的啟動抑制炎症性介質的釋放,包括IL-4、GM-CSF、IL-1β和MCP-1。同時還有非常明顯的抑制肥大細胞脫顆粒的作用。在DNP-BSA誘導的RBL-2H3細胞上,黃連解毒湯提取物能夠有效地抑制炎症、過敏介質的釋放(IL-4,TNF-α和MCP-1),並且能抑制其MAPKs、Syk和Lyn的表達。而白鮮皮同樣具有強大的抗肥大細胞脫顆粒作用,且能明顯的阻滯鈣離子內流,抑制PLC1/2,Syk和Lyn激活,從而的降低IL-4,TNF-α和MCP-1的分泌。
為了進一步探索黃連解毒湯和白鮮皮,我們選取DNCB誘導的BALB/c小鼠作用體內研究模型來評價其治療效果。在口服黃連解毒湯提取物(150、300、600mg/kg/d)和白鮮皮提取物(600、1200、2400mg/kg/d)治療2周後,小鼠皮膚所表現出的皮損得到明顯改善,皮膚肥大細胞和嗜酸性粒細胞浸潤減少;同時血清和皮膚中炎症介質的也明顯減少。黃連解毒湯提取物和白鮮皮提取物最大的不同在於對血清IgE和組胺的影響。 白鮮皮提取物能有效地抑制血清IgE和組胺的升高,但是黃連解毒湯對此毫無作用。 兩者
總而言之,本研究對黃連解毒湯和白鮮皮治療特應性皮炎的機制進行初步探索,為其在臨床上的運用提供實驗性的證據。
Atopic dermatitis (AD) is a common relapsing chronic inflammatory skin disease characterized by erythema, pruritus, excoriation, edema, exodus and thickening of the skin. It usually presents during early infancy and childhood, but can persist into adulthood. It has been reported that AD affects 15%-30% of children and 2%-10% of adult worldwide and has high familial occurrence. The exact pathophysiology of AD is still unclear, therefore, the major clinical therapy of AD is through symptom management, usually involving long-term use of topical corticosteroids and calcineurin inhibitors, some alternative anti-inflammatory treatment (e.g. UV light therapy), protection of skin barrier and education. However, conventional therapy usually comes with potential adverse events and the development of drug resistance. For these reasons, patients frequently seek other alternative therapeutic options, such as Chinese herbal medicine. Some Chinese herbs and formulas (oral or topical treatment) are applied to AD patients for years in clinical practice, such as Huang-Lian-Jie-Du Extract (HLJDE黃連解毒湯), Sixindaochi Yin (四心導赤飲), Qingxinpeitu Fang (清心培土方). However, the efficacy and potential mechanism are still lacking.
The present research project aimed to screen some formula and Chinese herbs for AD treatment through evaluating their anti-inflammatory and anti-allergic effect. Then, we investigate the biological activities and underlying mechanisms of these products, with a particular focus on HLJDE and DCE (白鮮皮), using relevant in vitro and in vivo AD experimental models.
HLJDE and DCE was extracted with 80% aqueous ethanol. Nitric Oxide (NO) form RAW264.7 and RBL-2H3 cell degranulation were used as the biomarkers for evaluating the anti-inflammatory and anti-allergic effect of selected Chinese medicines. The related cytokines and chemokines such as IL-1β and IL-4, and the close protein pathways (NF-κB, MAPKs, Syk and Lyn) in both cell model were detected for investigating the underlying mechanisms of HLJDE and Cortex Dictamni. Female Balb/c mice were sensitized with 1-chloro-2,4-dinitrobenzene (DNCB) for three days. After sensitization, mice were challenged by DNCB every three days and orally administrated with HLJDE (150, 300 and 600 mg/kg/d) and Cortex Dictamni (600, 1200, 2400 mg/kg/d) every day from day 14-29. After mice were sacrificed, the ears and dorsal skin were collected for histopathological studies (H&E and toluidine blue staining). Serum and dorsal skin were also collected for cytokines (IL-4, TNF-α and TSLP) and antibody (IgE) determination.
HLJDE exerted significant anti-inflammatory and anti-allergic effects through suppressing the production of allergic and inflammatory mediators via the inactivation of the NF-κB, MAPKs, Syk and Lyn pathway. In vivo model, HLJDE was able to reduce inflammatory symptoms in AD-like mice by suppressing the production of Th2-associated cytokine (IL-4) and pro-inflammatory cytokines (TNF-α), thereby inhibiting eosinophil and mast cell infiltration. On the other hand, its inhibitory effect on skin TSLP also suppressed Th2-type responses and reduce the the production of pro-inflammatory cytokines such as TNF-α.
Cortex Dictamni has potent anti-allergic effect through inhibiting mast cell degranulation and inhibiting the activation of PLC1/2, Syk and Lyn, not suppressing some inflammatory pathways (MAPKs). In the meanwhile, Cortex Dictamni could improve the AD-like symptoms in AD-like mice by inhibiting the serum IgE and histamine level. The findings help provide scientific rationale for prescribing this herbal formula for AD treatment.
Chen, Yunlong.
Thesis Ph.D. Chinese University of Hong Kong 2016.
Includes bibliographical references (leaves ).
Abstracts also in Chinese.
Title from PDF title page (viewed on …).
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Detailed summary in vernacular field only.
Chia-SuiChen та 陳佳穗. "Poly-γ-glutamate Microneedles for Treatment of Atopic Dermatitis-like Skin Lesion in Nc/Nga mice". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/2r972u.
Повний текст джерелаOliveira, Jéssica Alexandra Mendes de. "Dermatite atópica: dos tratamentos farmacológicos clássicos aos novos sistemas de libertação de fármacos." Master's thesis, 2019. http://hdl.handle.net/10316/88286.
Повний текст джерелаA dermatite atópica é a inflamação crónica dermatológica mais prevalente, caracterizando-se por um forte prurido e lesões eczematosas em diversas partes do corpo. Esta doença afeta crianças e adultos numa proporção de 20 % em diferentes partes do mundo. A fisiopatologia da dermatite atópica envolve uma mistura de fatores tais como os de foro ambiental, genético,imunológico e disfunção ao nível da barreira da pele. A base da prevenção consiste no uso diário de hidratantes para o restauro da função de barreira epidérmica. As terapias convencionais envolvem o uso de corticosteroides tópicos (terapia de primeira linha),inibidores de calcineurina, anti-histamínicos, antibióticos, fototerapia e fármacos imunossupressores sistémicos (em casos de dermatite atópica refratária). No entanto, a aplicação tópica é um mecanismo difícil devido à barreira natural da pele que limita a penetração dos fármacos. Decorrente de tal, os investigadores procuram desenvolver alternativas para as terapias convencionais. Os sistemas inovadores de libertação de fármacos têm vindo a ganhar uma atenção crescente devido à sua capacidade de melhorar a solubilidade,a biodisponibilidade, a penetração, a atuação nas células-alvo e reduzir os efeitos secundários dos fármacos usados no tratamento da dermatite atópica. Não obstante, estudos adicionais são necessários para se compreenderem os aspetos toxicológicos e a segurança a longo prazo das nanopartículas. Esta revisão aborda o potencial tratamento da dermatite atópica recorrendo a sistemas de libertação de nanopartículas assim como as limitações de foro toxicológico inerentes às mesmas.
Atopic dermatitis (AD) is the most prevalent relapsing chronic inflammation of the skin, characterized by strong itching and eczematous lesions in different parts of the body. This disease affects both children and adults in a ratio of 20 % in different parts of the world. The pathophysiology of AD concerns a mixture of factors, such as environmental, genetic,immunological and dysfunctions of the epidermal barrier. The base of prevention is the daily use of moisturizers to aid in the repair of the epidermal barrier function. The conventional therapies involve the use of topical corticosteroids (TCSs) (first-line therapy), calcineurininhibitors (TCIs), antihistamines, antibiotics, phototherapy and systemic immunosuppressantdrugs (in severe refractory cases of AD). However, topical delivery to the skin is a difficult task to achieve due to the natural barrier of skin which limits the penetration of drugs.Therefore, researchers have sought to develop alternatives to conventional therapies.Innovative delivery systems have achieved increasing attention due to their capacity to enhance solubility, bioavailability, penetration, targeting specific types of cells and reduce the secondary effects of the drugs employed in the treatment of AD. Nonetheless, additional studies are needed to understand the toxicological aspects and long-term safety of nanoparticles (NPs).This review includes the potential treatment of AD with nanoparticle skin delivery systemsand their toxicologic concerns.
"Use of diluted bleach baths for the treatment of Staphylococcus aureus colonization/infection in atopic dermatitis: 漂沐浴對濕疹金黃葡萄球菌感染的治療情況". 2015. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292121.
Повний текст джерелаThesis M.Phil. Chinese University of Hong Kong 2015.
Includes bibliographical references (leaves 128-143).
Abstracts also in Chinese; appendix in Chinese.
Title from PDF title page (viewed on 04, January, 2017).
Tsang, Yin Ching.
Machado, Carlos Filipe Rodrigues. "Novas abordagens terapêuticas na dermatite atópica." Master's thesis, 2018. http://hdl.handle.net/10284/7338.
Повний текст джерелаAtopic dermatitis is a chronic inflammatory skin disease that affects all age groups with the highest incidence at younger ages. Is characterized by cutaneous xerosis, and eczematous, erythematous, exudative, and crusty lesions with characteristic morphology and distribution. The dysfunction of the skin barrier and the immune system are the main factors that present greater magnitude when associated to colonization and frequent infection by the pathogenic bacteria Staphylococcus aureus. The prevention of clinical manifestations is the main focus of treatment of the disease and it is in this perspective that the interest in the use of pre and probiotics appears with either topical or intestinal level performance. Preliminary studies are optimistic for its use, but further studies are needed to determine the full effect that pre or probiotics have on the skin, indicating that there are considerable challenges ahead, but also many opportunities. In the first part of this work the description of atopic dermatitis, its characteristics and complications is made. The following is a review of the cutaneous microbiota and the importance of maintaining a balanced and functional commensal microbiota. Then the different possible treatments for the disease and its order of choice are presented and finally the possible use of pre and probiotics in the prevention and attenuation of the atopic symptoms is explored with a bibliographical revision to different clinical studies and future possibilities for the implementation of these new therapies in clinical practice.