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Статті в журналах з теми "Astronaut group"
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Bimm, Jordan. "Andean Man & the Astronaut." Historical Studies in the Natural Sciences 51, no. 3 (June 1, 2021): 285–329. http://dx.doi.org/10.1525/hsns.2021.51.3.285.
Повний текст джерелаАнотація:
In 1958, Bruno Balke, a former German Luftwaffe doctor working for the United States Air Force (USAF), led a team of airmen up Colorado’s Mount Evans. Could acclimatization to the thin mountain air boost the oxygen efficiency of future astronauts living in artificial low-pressure spacecraft environments? To judge their improvement, Balke, an expert in the nascent field of space medicine, compared their performance not with military test-pilots, but with high-altitude Indigenous people he had studied in the Peruvian Andes. This article expands discussions of race in space history beyond Black scientists, mathematicians, and pilots in the Civil Rights era to this earlier case of the permanent residents of Morococha, Peru, who participated in efforts to define an ideal spacefaring body. More than recovering the story of a nearly forgotten group of astronaut-adjacent test-subjects, this article shows how racial discrimination in space medicine functioned by inclusion. Balke studied and even celebrated the bodies of Morocochans, but never considered them potential astronauts. This article begins with Balke’s participation in the 1938 Nazi-funded expedition to summit Nanga Parbat in the Himalayas, and his follow-on work acclimatizing Luftwaffe pilots during World War Two. Then it focuses on his USAF work in the 1950s studying miners living and working in Morococha, Peru, and his attempt to replicate their altitude tolerance in American airmen on Mount Evans. Recovering Balke’s work places the high-altitude Indigenous person and the mountaineer alongside the familiar figure of the pilot in the genealogy of the early American astronaut.
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Stewart, Rod. "Psychology of Spaceflight: II. Suggested Bases of Space Motion Sickness: Perceptual Disorientation and Elevated Stomach pH." Perceptual and Motor Skills 60, no. 1 (February 1985): 189–90. http://dx.doi.org/10.2466/pms.1985.60.1.189.
Повний текст джерелаАнотація:
Suggested causes of space-motion sickness are inferred from the experiences of a group of astronaut candidates and from the vomit pH values of nonastronauts. Both groups experienced simulated weightlessness in an airplane.
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Glasser, Leanne, Emily Young, and Pauline Sameshima. "The Supermodel Astronaut Challenge: traversing frames of mind." Qualitative Research Journal 19, no. 4 (November 11, 2019): 415–25. http://dx.doi.org/10.1108/qrj-02-2019-0023.
Повний текст джерелаАнотація:
Purpose The Supermodel Astronaut (SMA) Challenge began with a group of women in a graduate class who joined together to take the pledge “I Am Enough.” The goals of the pledge are to practice positive affirmative actions of self-acceptance, self-grace, self-improvement and positive encouragement of oneself and others. The paper aims to discuss this issue. Design/methodology/approach The SMA Challenge involves an online video pledge to encourage women and girls to demonstrate their opposition to the promotion of singular ideals of body perpetuated through media. Various individuals and groups have created music videos titled SMA to the soundtrack created by Ellen Tift (the originator of the project). Findings Here, framed by Daignault’s (1983) theories on curriculum construction, the authors critically reflect on their support of the idea of the video, but also their apprehension and insecurities in participating in the video production. Originality/value From reflections, writings and dialogic discussions, they determined five embodied frames of mind that supported them in traversing the liminal space of new learning: imagining the possible, learning in doing, settling in vulnerability, journeying through empowerment and heightening self-reflection.
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Ireland-Piper, Danielle, and Steven Freeland. "Human Rights and Space: Reflections on the Implications of Human Activity in Outer Space on Human Rights Law." Groningen Journal of International Law 9, no. 1 (September 28, 2021): 101–27. http://dx.doi.org/10.21827/grojil.9.1.101-127.
Повний текст джерелаАнотація:
What are the implications of human activity in outer space for international human rights law? In this article, we reflect on these questions with a view to advancing dialogue on the intersection between space law and human rights. We do so by considering the impact of extra-terrestrial human activities such as access to space and remote-sensing activities, space debris, space mining, the weaponisation and militarization of space, and the assertion of criminal jurisdiction extra-terrestrially. Ultimately, we conclude that human activity in space has significant consequences for the advancement of human rights. While, in our view, existing legal frameworks on international human rights law apply extra-terrestrially, there is still scope for specialist frameworks guarding human rights law in the context of human activity in outer space.
"To confine our attention to terrestrial matters would be to limit the human spirit."
~ Stephen Hawking, Astrophysicist
"Space is for everybody. It's not just for a few people in science or math, or for a select group of astronauts. That's our new frontier out there, and it's everybody's business to know about space."
~ Christa McAuliffe, Teacher and Challenger Astronaut
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Truchon, Laurence, Catherine Lacombe, Myriam Doyon, Jean-Sébastien Tremblay-Roy, Claude Cyr, Ghassan Choker, Sébastien Roulier, Yves Patenaude, and Miriam Santschi. "46 Preparation for MRI through imaginary visualization of an astronaut’s rocket journey to space for children 3 to 7 years old." Paediatrics & Child Health 25, Supplement_2 (August 2020): e19-e20. http://dx.doi.org/10.1093/pch/pxaa068.045.
Повний текст джерелаАнотація:
Abstract Background Medical imaging by magnetic resonance imaging (MRI) is now frequently used in the pediatric population. Up to now, sedation is used almost systematically to provide adequate immobilization during the exam. However, sedation is not without risks. Objectives The objective of this study is to evaluate whether a prior familiarization to MRI procedures with a video staging the imaginary world of an astronaut’s rocket journey into space will decrease the number of required sedations for an MRI for children aged 3 to 7 years old. Design/Methods A total of 136 children between 3 and 8 years of age, referred for an MRI between April 2016 and October 2019, were recruited for this prospective non-randomized quasi-experimental study. The control group (April 2016 to August 2017, n=73) received the usual sedation protocol for MRI used in our center. A pictorial step-by-step brochure and a three-minute video explaining the parallel between the MRI reality and the imaginary world of an astronaut was developed and shown to the intervention group (July 2018 to October 2019, n=63) before the MRI. Compared to the control group, any MRI in the intervention group was first attempted without sedation. Results A significant decrease in the number of sedations was observed in the intervention group (n=18; 28.6%) compared to the control group (n=47; 64.4%) (odds ratio: 0.22; p <0.001). The effect of the intervention was even stronger for younger children (3 and 4 years old) (odds ratio: 0.03) compared to older children (5 years old and above) (odds ratio: 0.3). After logistic regression, age remained the sole other significant factor to influence the need for sedation, even in the intervention group. Conclusion A video and a brochure staging the imaginary world of an astronaut’s rocket journey into space showed just before a MRI significantly reduces the rate of sedation in children aged 3 to 7 years, especially for young children. We believe the implementation of interventions using imaginary visualization in this age group should be widely used to limit the necessity of sedation.
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Patel, Rutulkumar, Scott Welford, and Stanton L. Gerson. "The Effects of Galactic Cosmic Radiation Exposure on Hematopoietic Stem Cell Dysfunction and Oncogenesis." Blood 128, no. 22 (December 2, 2016): 5297. http://dx.doi.org/10.1182/blood.v128.22.5297.5297.
Повний текст джерелаАнотація:
Abstract Natural sources of radiation in space include galactic cosmic rays (GCR), solar energetic particles (SPE) and trapped energetic particles in a planetary magnetic field. These different sources of space radiation consist of protons of various energies, particle nuclei of high energy and charge (HZE) and neutrons of different energies. These sources are difficult to shield because of their high energies and dense ionization patterns, thus posing significant health risks to astronauts on long term inter-planetary missions. Efforts to protect astronauts from harmful cosmic radiation require a deeper understanding of the effects of GCR on human health. In particular, very little is known about the effects of GCR exposure on the hematopoietic stem cell (HSC) population and whether disruptions in genetic stability in HSCs could result in the development of hematopoietic malignancies in astronauts on deep space missions. The average age of shuttle crew has risen above 46 years, and our work and others have shown that HSCs display diminished function with age. Recent data from our group has demonstrated that middle-aged individuals show frequent defects in DNA mismatch repair (MMR) in HSCs. MMR corrects DNA mismatches generated by DNA polymerase during replication which prevents mutations from becoming permanent in dividing cells. Thus, MMR plays a crucial role in the DNA damage response pathway to prevent short-term mutagenesis and long-term tumorigenesis. Several human MMR proteins have been identified as MutS and MutL homologues consisting of MSH2 and MLH1 heterodimers that functions in DNA mismatch/damage recognition, endonuclease activity and termination of mismatch-provoked excision. Our group has shown that humans accumulate microsatellite instability (MSI) with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age. Therefore, we employed a DNA mismatch repair deficient mouse model (MLH1+/- and MLH1-/-) to study the effects of different radiation sources including 56Fe, 28Si, 4He, 1H and ᵞ-rays on HSCs to examine HSCs of potential astronaut population under GCR conditions. The complete blood count (CBC) data after 5 months and 9 months of whole body irradiation with different ions showed a slight dose-dependent decrease in all blood counts but absence of any significant difference in CBC of MLH1+/+ vs MLH1+/- mice. In addition, CFU and competitive repopulation data demonstrated a radiation quality effects on HSC function, but not an MLH1 effect. These results demonstrate that hematopoietic stem cell function is normal and that a MLH1 defect does not differentiate progenitor and mature effector cells following HZE radiation. To study long term effects of different ions on the potential for disease progression in a MLH1 dependent manner, we performed whole body irradiation with 56Fe, 28Si, 1H and ᵞ-rays on MLH1+/+ and MLH1+/- mice and followed them up to 18 months post exposure. We observed that MLH1+/- mice show dramatic increases in lymphomagenesis 10-12 months after 56Fe irradiation compared to wild type mice, with greater than 60 % of MLH1+/- mice developed lymphomas at doses 10 cGy and 100 cGy compared to less than 10 % of wild type. For comparison, roughly 10 % of MLH1+/- mice developed lymphomas when mice were treated with whole body sparsely ionizing ᵞ-rays at 100 cGy compared to none of the control. Thus the date show that MMR defects in HSCs lead to sensitization to radiation induced hematopoietic malignancy and that radiation quality effects exacerbate the sensitivity. The findings could have profound effects on astronaut screening, as well as lead to important questions regarding safety of ion therapy and development of second malignancies for cancer patients who remain on Earth. Disclosures No relevant conflicts of interest to declare.
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LIU, HAOTING, FENGGANG XU, QIANXIANG ZHOU, ZHIZHEN LIU, FAN LI, CHUNHUI WANG, and SHANGUANG CHEN. "HEALTHY STATE MONITOR OF UPPER LIMB FOR SPACE FLIGHT TASK BASED ON SIGNAL ANALYSES OF MULTIPLE MUSCLE FORCES." Journal of Mechanics in Medicine and Biology 17, no. 04 (December 14, 2016): 1750061. http://dx.doi.org/10.1142/s0219519417500610.
Повний текст джерелаАнотація:
A novel healthy state monitor method of upper limb for space flight task is proposed. Without taking other complex diagnosis equipment in orbit, this method only uses the ordinary exercise instruments to collect and analyze the multiple muscle forces of astronauts, and deduces where the serious muscle atrophy occurs in their muscle groups of upper limb. First, the typical multiple muscle forces data of upper limb are accumulated. A 45-day 6-degree head-down tilt bed rest experiment together with a multiple muscle forces test experiment are carried out to collect the corresponding data. These data include both the muscle force data of healthy state and the related data of unhealthy state. Second, the Wavelet Packet Transform (WPT) and the Empirical Mode Decomposition (EMD) methods are used to compute the signal features of these data above. Third, a Support Vector Machine (SVM) classifier is trained by the related signal features. Finally, the trained SVM can be utilized to evaluate the healthy state of upper limb in orbit for astronaut. If the output of SVM is negative, the C-means method and the Euclidean distance can be used to locate the abnormal muscle forces and muscle groups. The concept of typical muscle group health state evaluation for upper limb is emphasized in this paper. The comparisons among the traditional diagnosis-based method, the electromyogram (EMG)-based muscle forces analysis method, and the proposed method are made. Many experiment results on ground have verified the effectiveness of proposed method.
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Ogunyemi, Dotun. "Defeating Unconscious Bias: The Role of a Structured, Reflective, and Interactive Workshop." Journal of Graduate Medical Education 13, no. 2 (February 25, 2021): 189–94. http://dx.doi.org/10.4300/jgme-d-20-00722.1.
Повний текст джерелаАнотація:
ABSTRACT Background Unconscious or implicit biases are universal and detrimental to health care and the learning environment but can be corrected. Historical interventions used the Implicit Association Test (IAT), which may have limitations. Objective We determined the efficacy of an implicit bias training without using the IAT. Methods From April 2019 to June 2020, a 90-minute educational workshop was attended by students, residents, and faculty. The curriculum included an interactive unconscious biases presentation, videoclips using vignettes to demonstrate workplace impact of unconscious biases with strategies to counter, and reflective group discussions. The evaluation included pre- and postintervention surveys. Participants were shown images of 5 individuals and recorded first impressions regarding trustworthiness and presumed profession to unmask implicit bias. Results Of approximately 273 participants, 181 were given the survey, of which 103 (57%) completed it with significant increases from pre- to postintervention assessments for perception scores (28.87 [SEM 0.585] vs 32.73 [0.576], P < .001) and knowledge scores (5.68 [0.191] vs 7.22 [0.157], P < .001). For a White male physician covered in tattoos, only 2% correctly identified him as a physician, and 60% felt he was untrustworthy. For a smiling Black female astronaut, only 13% correctly identified her as an astronaut. For a brooding White male serial killer, 50% found him trustworthy. Conclusions An interactive unconscious bias workshop, performed without the use of an IAT, was associated with increases in perceptions and knowledge regarding implicit biases. The findings also confirmed inaccurate first impression stereotypical assumptions based on ethnicity, outward appearances, couture, and media influences.
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Malašauskienė, Dovilė, Ramūnas Antanaitis, Vida Juozaitiene, Mindaugas Televičius, Mingaudas Urbutis, Arūnas Rutkauskas, Agnė Šimkutė, and Giedrius Palubinskas. "Trends in Changes of Automatic Milking System Biomarkers and Their Relations with Blood Biochemical Parameters in Fresh Dairy Cows." Veterinary Sciences 8, no. 3 (March 9, 2021): 45. http://dx.doi.org/10.3390/vetsci8030045.
Повний текст джерелаАнотація:
The aim or this study was to determine the relationship between non-esterified fatty acids and biomarkers from an automatic milking system (AMS). Fresh dairy cows (n = 102) were selected and milked in Lely Astronaut® A3 milking robots. The rumination time (RT), body weight (BW), milk content and composition parameters, milk fat/protein ratio (F/P), and milk electrical conductivity were registered by the same milking robots. For examining non-esterified fatty acids (NEFAs), blood samples were acquired from cows in the dry period. According to the NEFA concentrations, all cows were divided into two groups: Group I, with <0.300 mEq/L (n = 66), and Group II, with ≥0.300 mEq/L (n = 36). Albumin (ALB), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), and cortisol concentrations were also analyzed once a week up to 30 days in milking. The study revealed that the cows in Group I had higher concentrations of ALB, cortisol, and GGT, but the average concentration of AST was lower. In Group 1, the milk F/P was higher, but the milk yield was lower. We hypothesize that biomarkers from AMS could help in the early diagnosis of metabolic diseases after calving or to control negative energy balance before calving.
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Krishnan, V., B. V. Jay Dhwarak, N. Nithyanandan, and I. Paul Theophilus Rajakumar. "Activated Carbon, Lithium Hydroxide, Calcium Hydroxide Scrubber for Carbon-Di-Oxide Capture from Exhausts of Vehicles." Applied Mechanics and Materials 812 (November 2015): 64–69. http://dx.doi.org/10.4028/www.scientific.net/amm.812.64.
Повний текст джерелаАнотація:
Vehicular pollution is one of the main reasons for air pollution in many cities. According to Industrial Environment Carbon, every gallon of gasoline produces 14% total volume of carbon dioxide, this will ultimately lead to air pollution and global warming [10]. To minimize the emission level, physical adsorption [4] can be used for the removal of organic molecule from exhaust gas stream by impulse collision. So our proposed system consists of a filter matrix bed, made of activated carbon, calcium hydroxide, lithium hydroxide [8,9]. Activated carbon is the most widely used adsorbent. It can adsorb a wide range of pollutants with varying dimensions by its broad pore distribution, micro and mesophores. Calcium group can naturally adsorb carbon component and get transformed into lime. Lithium hydroxide is widely used as carbon capturing material in space craft for adsorbing carbon dioxide exhaled by astronaut as a breathing scrubber. So collectively these three carbon sequestrating material can efficiently remove the pollutant by chemisorptions [2].
Дисертації з теми "Astronaut group"
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Adeolu, Ayano. "Leonid Kadenyuk – the first ukrainian cosmonaut." Thesis, НТУ "ХПІ", 2016. http://repository.kpi.kharkov.ua/handle/KhPI-Press/21763.
Повний текст джерелаКниги з теми "Astronaut group"
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Brady, Joseph V. Behavioral and biological interactions with small groups in confined microsocieties. Baltimore, Md: The Johns Hopkins University, 1986.
Знайти повний текст джерелаЧастини книг з теми "Astronaut group"
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Seedhouse, Erik. "Space Radiation Analysis Group." In Space Radiation and Astronaut Safety, 37–47. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-74615-9_4.
Повний текст джерела
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Mezzacappa, Elizabeth. "Astronaut Crew Selection: Group Cohesiveness, Deviation, Stress, and Conformity." In Advances in Intelligent Systems and Computing, 195–206. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-93885-1_18.
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DiBiase, Warren James, Judith R. McDonald, and Kellan Strong. "Constructing a Marshmallow Catapult." In Cases on STEAM Education in Practice, 260–76. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-2334-5.ch013.
Повний текст джерелаАнотація:
This case will present a project-based scenario where students will take the place of an astronaut stranded on Mars. Like the character in the Disney film The Martian, the astronaut only has a small collection of “spare parts” at his disposal to ensure survival. In this scenario, our astronauts meet predators and in an effort to fend them off, they must design and construct a catapult. During this deep dive process the astronauts working in groups of four, will take an inventory of spare parts available, design and draw a plan for building, build the catapult, test the catapult, and then go through a series of revisions, retesting and sharing their redesigns.
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Delmarco, Gustavo, Thais Russomano, Alyson Calder, Felipe Falcão, Dario F. G. Azevedo, Subhajit Sarkar, Simon Evetts, and Samuel Moniz. "Evaluation of External Cardiac Massage Performance During Hypogravity Simulation." In Encyclopedia of Healthcare Information Systems, 551–60. IGI Global, 2008. http://dx.doi.org/10.4018/978-1-59904-889-5.ch070.
Повний текст джерелаАнотація:
Preservation of astronaut crew health during an exploration mission to the Moon or Mars will be crucial to mission success. The likelihood of a life-threatening medical condition occuring during a mission to Mars has been estimated by NASA to be 1% per year (Johnston, 1998; Johnston, Campbell, Billica, & Gilmore, 2004). Since basic life support is a vital skill in critical care medicine, plans must be in place for cardiopulmonary resuscitation in both microgravity and hypogravity (i.e., on the surface of the Moon or Mars). Following the design of a body suspension device to simulate a hypogravity environment, subjects performed external chest compressions in 1G, 0.17G (Lunar), 0.38G (Mars), and 0.7G (Planet X). Chest compression adequacy was assessed by means of rate and depth. Heart rate immediately before and after three minutes of chest compression gave a measure of rescuer fatigue. Elbow flexion was measured using an electrogoniometer in order to assess the use of arm muscles to achieve chest compressions. This study found that the mean depth (Lunar and Mars) and rate (Mars) of chest compression was below American Heart Association recommendations during hypogravity simulation in the female group. Furthermore, elbow flexion proved to be significantly greater during Lunar and Mars hypogravity simulation than that of the 1G control condition, suggesting that upper arm force may be used to counter the loss of body weight in an attempt to maintain adequate chest compression under these conditions.
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Vargas-Bernal, Rafael. "Advances in Electromagnetic Environmental Shielding for Aeronautics and Space Applications." In Recent Trends on Electromagnetic Environmental Effects for Aeronautics and Space Applications, 80–96. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-4879-0.ch003.
Повний текст джерелаАнотація:
Electromagnetic environmental shielding is one of the main research topics for the development of aeronautical and space applications. Numerous research groups around the world study the problems that space systems and astronauts experience when these are subjected to space radiation. Despite the progress made so far, different proposals of advanced materials have been continuously proposed throughout the history of space career to protect space systems and astronauts against the solar particle events (SPE), cosmic rays galactic (GCRs), and proton-electron radiation (PERs). This chapter presents the recent advances made about space environmental shielding and that have been reported so far to visualize the future perspectives that this type of research must carry out so that future space voyage is completely reliable for space systems and astronauts. This research area is fully current, and its experimental success will depend on the work done by all space researchers and professionals.
Тези доповідей конференцій з теми "Astronaut group"
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Maynard, Jacqueline A., Ahmad S. Arabiyat, Anna Elefante, Lucas Shearer, Eoin King, and Andrea Kwaczala. "Using Acoustic Waves to Modulate Stem Cell Growth and Differentiation." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-71341.
Повний текст джерелаАнотація:
During spaceflight, the loss of mechanical loads due to microgravity leads to rapid bone loss, where bone deteriorates at a rate of 1–2% per month, where some astronauts can lose as much as 20% of their skeletal mass in a single expedition [NASA, 2001]. In order to prevent muscle and bone loss, long-term space flight exercise regimes are strictly implemented [Shackleford, 2004]. Current research has demonstrated that mechanical vibrations can help to maintain or improve bone mass [Chan, 2013] and reduce adiposity [Chen, 2015, Sen, 2011] when signals are applied at the appropriate frequency and amplitude. We have developed an acoustic sound chamber that can apply sound waves to stem cells grown in vitro. Characterization of the culture conditions inside the vibration chamber showed considerable variance across the culture plates where an applied acceleration of 0.6g varied at different spots in a 12-well tissue culture plate from as low as 0.47g to 0.78g. We believe the variance is caused by differences in the rigidity of the culture plates that makes the waves transmit inconsistently through the plastic. We hypothesized acoustic waves would induce osteogenic differentiation when applied to stem cells. We utilized pre-osteoblastic stem cells (MC3T3-E1-Subclone 4) to observe the effects of acoustic waves when applied at 0.3g and 0.6g, compared to non-vibrated controls. Cells were vibrated for 30 minutes a day for either 6 days (n = 24/group) or 12 days (n = 12/group). Cellular changes were characterized by assessing well-by-well cell number by a manual cell count and mineral content by Alizarin Red S staining. Differences between groups were determined using One-Way ANOVA with a post hoc test: Student’s t-test. To assess the effects of the variance across the culture plates, correlative analysis was conducted for well-by-well variation using Regression Analysis. Acoustically vibrated wells had 10x more cells after 6 days and showed more mineralization than non-vibrated wells at both 6 and 12 days. Acoustic waves have the ability to increase cell proliferation and can drive stem cell differentiation towards an osteoblastic lineage, this could lead to therapies that prevent bone loss during spaceflight.
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Shao, Guangbin, Longqiu Li, Hongtao Zhang, Xinrong Zhou, Tingting Li, and Hualei Dong. "Experimental and Numerical Investigation of Vision Impairment in Long-Term Exposure to Microgravity." In ASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/detc2016-59433.
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Recently researches have reported the ocular structural and functional changes observed in astronauts after long-duration space flight, which includes optic disk edema, globe flattening, choroidal folds, hyperopic shifts and reduction of near visual acuity. This syndrome, which is called the Visual Impairment/Intracranial Pressure (VIIP) Syndrome, is reported due to the alterations of translaminar pressure and some other factors (concentration of CO2, genotype, B-vitamin status, androgens, etc.) in microgravity or in space station. On account of the shortage of measurement and limit of sample size in space experiments, the study of VIIP Syndrome was difficult to make progress. In this research, numerical analysis combined with animal experiment were performed. In the animal experiment, hindlimb suspension (HLS) model was used to simulate the cephalic liquid shifts of Sprague-Dawley (SD) rats in microgravity, as well as fundus photography and optical coherence tomography (OCT) were executed to detect the ocular structural changes. For both the experimental group and the control group, the illumination, temperature and feeding were strictly controlled, well the watering was unrestricted, during the long-term hinlimb suspension. The ocular structural changes and the physiological index including weight and intraocular pressure (IOP) were evaluated. A numerical model of eye was established, then finite element analysis was performed to study the biomechanical response of ocular structure due to the changes of translaminar pressure. We observed that the changes of the ocular structure in rats after the long-term hindlimb suspension were consistent with the finite element simulation results. The findings in this research showed the significance of animal experiment and numerical analysis for the study of VIIP Syndrome.
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Hu, M., R. Yeh, M. Lien, and Y. X. Qin. "In Vivo Mesenchymal Stem Cell Proliferation in Response to Dynamic Fluid Flow Stimulation." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80586.
Повний текст джерелаАнотація:
Osteoporosis is a debilitating disease characterized as decreased bone mass and structural deterioration of bone tissue. Osteoporotic bone tissue turns itself into altered structure, which leads to weaker bones that are more susceptible for fractures. While often happening in elderly, long-term bed-rest patients, e.g. spinal cord injury, and astronauts who participate in long-duration spaceflights, osteoporosis has been considered as a major public health thread and causes great medical cost impacts to the society. Mechanobiology and novel stimulation on regulating bone health have long been recognized. Loading induced bone fluid flow, as a critical mechanotransductive promoter, has been demonstrated to regulate cellular signaling, osteogenesis, and bone adaptation [4]. As one of the factors that mediate bone fluid flow, intromedullary pressure (ImP) creates a pressure gradient that further influence the magnitude of mechanotransductory signals [5]. As for a potential translational development of ImP, our group has recently introduced a novel, non-invasive dynamic hydraulic stimulation (DHS) on bone structural enhancement. Its promising effects on inhibition of disuse bone loss has been shown with 2 Hz loading through a 4-week hindlimb suspension rat study followed by microCT analysis. At the cellular level, mesenchymal stem cells (MSCs) are defined by their self-renewal ability and that to potentially differentiate into the cells that form tissues such as bone [1]. To further elucidate the cellular effects of DHS and its potential mechanism on bone quality enhancement, the objective of this study was to measure MSC quantification in response to the in vivo mechanical signals driven by DHS.
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Shikata, Tetsuo, Toshihiko Shiraishi, Kumiko Tanaka, Shin Morishita, and Ryohei Takeuchi. "Effects of Amplitude and Frequency of Vibration Stimulation on Cultured Osteoblasts." In ASME 2007 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/detc2007-34949.
Повний текст джерелаАнотація:
Mechanical stimulation to bones affects osteogenesis such as decrease of bone mass of astronauts under zero gravity, walking rehabilitation to bone fracture and fracture repair with ultrasound devices. Bone cells have been reported to sense and response to mechanical stimulation at cellular level morphologically and metabolically. In the view of mechanical vibrations, bone cells are deformed according to mechanical stimulation and their mechanical characteristics. Recently, it was reported that viscoelasticity of cells was measured using tensile and creep tests and that there was likely natural frequency and nonlinearity of cells in the sense of structural dynamics. It suggests that there is effective frequency and amplitude of mechanical stimulation on osteogenesis by bone cells. In this study, sinusoidal inertia force was applied to cultured osteoblasts, MC3T3-E1, and effects of frequency and acceleration amplitude of mechanical vibration on the cells were investigated in respect of cell proliferation, cell morphology, bone matrix generation and alkaline phosphatase (ALP) gene expression. After the cells were cultured in culture plates in a CO2 incubator for one day and adhered on the cultured plane, vibrating groups of the culture plates were set on an aluminum plate attached to a exciter and cultured under sinusoidal excitation in another incubator separated from non-vibrating groups of the culture plates. Acceleration amplitude and frequency were set to several kinds of conditions. The time evolution of cell density was obtained by counting the number of cells with a hemocytometer. The cell morphology was observed with a phase contrast microscope. Calcium salts generated by the cells were observed by being stained with alizarin red S solution and their images were captured with a CCD camera. The vibrating groups for the cell proliferation and the calcium salts staining were sinusoidally excited for 24 hours a day during 28-day cultivation. Gene expression of ALP was measured by a real-time RT-PCR method. After the vibrating groups for the PCR were excited for 6 hours, the total RNAs were extracted. After reverse transcription, real-time RT-PCR was performed. Gene expression for ALP and a housekeeping gene were determined simultaneously for each sample. Gene levels in each sample were normalized to the measured housekeeping gene levels. As a result, it is shown that saturate cell density becomes high and bone matrix generation is promoted by applying mechanical vibration and that there may be some peaks to frequency and a certain threshold value to acceleration amplitude of mechanical vibration for saturation cell density and bone matrix generation.
Звіти організацій з теми "Astronaut group"
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Styugina, Anastasia. Internet game "Sign me up as an astronaut" for the formation of the social and psychological experience of younger adolescents with disabilities by means of game psychocorrection. Science and Innovation Center Publishing House, December 2020. http://dx.doi.org/10.12731/sign_me_up_as_an_astronaut.
Повний текст джерелаАнотація:
In the practice of a teacher-psychologist at the School of Distance Education, the game “Sign me up as an astronaut”, developed by the author, was tested, aimed at developing the skills of social and psychological interaction in younger adolescents with disabilities through the awareness and strengthening of personal resources by means of game psychocorrection. The specifics of the work of a psychologist at the School of Distance Education are determined by the following circumstances: - students have a severe disability and the corresponding psychophysical characteristics: instability of the emotional-volitional sphere, lack of motivation, severe physical and mental fatigue, low level of social skills, etc. - the use of distance educational technologies in psychocorrectional work; - lack of methodological recommendations for psychocorrectional work in conditions of distance technologies with school-age children. Such recommendations are available mainly for adults, they relate to the educational process, but they do not cover the correctional process. There is enough scientific and methodological literature on psychological and pedagogical correction, which is the basis for ensuring the work of a practicing psychologist, but there are difficulties in transferring these techniques, games, etc. - to the remote mode of correctional and developmental work, especially in the form of group work. During the game, various social and psychological situations are solved, which are selected strictly according to the characteristics of the social experience of the participants.