Дисертації з теми "Arthriti"
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Bellan, Mattia. "Vitamin D in Rheumatoid Arthritis: potential implications for disease control and comorbidities management." Doctoral thesis, Università del Piemonte Orientale, 2018. http://hdl.handle.net/11579/102686.
Повний текст джерелаRAVANI, Annalisa. "Pharmacological characterization of adenosine receptors in chronic inflammatory rheumatic diseases." Doctoral thesis, Università degli studi di Ferrara, 2018. http://hdl.handle.net/11392/2478762.
Повний текст джерелаRheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are chronic inflammatory rheumatic diseases that affect joints, causing debilitating pain and disability. Adenosine receptors (ARs) play a key role in the mechanism of inflammation, and the activation of A2A and A3AR subtypes is often associated with a reduction of the inflammatory status. The first aim of this study was to investigate the involvement of ARs in patients suffering from early-RA (ERA), RA, AS and PsA. Messenger RNA (mRNA) analysis and saturation binding experiments indicated an upregulation of A2A and A3ARs in lymphocytes obtained from patients when compared with healthy subjects. A2A and A3AR agonists inhibited nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) activation and reduced inflammatory cytokines release, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6. Moreover, A2A and A3AR activation mediated a reduction of metalloproteinases (MMP)-1 and MMP-3. The effect of the agonists was abrogated by selective antagonists demonstrating the direct involvement of these receptor subtypes. These data confirmed the involvement of ARs in chronic autoimmune rheumatic diseases highlighting the possibility to exploit A2A and A3ARs as therapeutic targets, with the aim to limit the inflammatory responses usually associated with RA, AS and PsA. The purpose of the second chapter of this thesis, was to evaluate the modulation of A2A and A3ARs in patients suffering from RA, AS and PsA after different pharmacological treatments. We investigated A2A and A3AR density and functionality in pathologies progression by using a longitudinal study in RA, AS and PsA patients before and after methotrexate (MTX), anti-TNFa agents or rituximab treatments. A2A and A3ARs were analyzed by saturation binding assays in lymphocytes from patients throughout the 24-month study timeframe. In lymphocytes obtained from RA patients, the A2A and A3AR up-regulation was gradually reduced in function of the treatment time. Taken together, these data confirmed the involvement of A2A and A3ARs in chronic inflammatory rheumatic disease progression and highlighted that A2A and A3AR agonists could represent a physiological-like therapeutic alternative for RA treatment.
SILVAGNI, ETTORE. "Tofacitinib improves mitochondrial function in psoriatic arthritis fibroblast-like synoviocytes via autophagy modulation." Doctoral thesis, Università degli studi di Ferrara, 2022. http://hdl.handle.net/11392/2482880.
Повний текст джерелаInnala, Lena. "Early rheumatoid arthritis aspects of severity and co-morbidity." Doctoral thesis, Umeå universitet, Reumatologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88477.
Повний текст джерелаBASSI, ANDREASI Rita. "MULTIDISCIPLINARY APPROACHES AND INTERACTION NETWORK IN THE DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITIS." Doctoral thesis, Università degli studi di Ferrara, 2018. http://hdl.handle.net/11392/2488115.
Повний текст джерелаI differenti approcci multidisciplinari affrontati e descritti nella presente tesi sono stati effettuati con l'intento di arricchire le conoscenze in ambito di Artrite Reumatoide (AR), patologia a eziologia multifattoriale, progressiva ed autoimmune. Lo studio caso-controllo, focalizzato sull'individuazione di un profilo genetico di rischio in pazienti italiani con diagnosi di AR, ha riportato la variante HLA-DQA2 rs9275595 T>C significativamente associata ad insorgenza. L'analisi delle interazioni SNP × SNP ha rivelato un significativo effetto sinergico della combinazione fra le varianti HLA-DQA2 rs9275595 e HLA-DRB1 rs660895 A>G, suggerendo che, oltre al singolo effetto, il risultato maggiore si ha dall'interazione fra varianti appartenenti al complesso HLA. L'identificazione di biomarkers predittivi di suscettibilità, di progressione e di efficacia del trattamento impiegato è stata condotta in pazienti con Artrite Indifferenziata/Artrite Reumatoide Precoce (UA/ERA). Il follow-up a 6 mesi ha consentito la stratificazione dei soggetti UA in base all'insorgenza o meno della patologia, mentre per i pazienti ERA in base alla variazione del DAS28 (Disease Activity Score). I risultati delle interazioni genetiche e sierologiche relativamente alla progressione di AR, hanno individuato un algoritmo predittivo di efficacia terapeutica, evidenziando una relazione sinergica fra il Fattore Reumatoide (RF), la Resistina e la variante HLA-DRB1 rs6910071 A>G. Focalizzandosi sullo studio del dimorfismo sessuale, è stato riportato un significativo effetto genere-dipendente nel contesto della farmacogenetica del Methotrexate (MTX): infatti la variante HLA-G 14bp D>I costituisce un fattore predittivo dell'inefficacia del MTX solo nelle pazienti femmine. Approfondendo l'indagine su peculiari caratteristiche del genere femminile che possano interagire con il genotipo HLA-G, è risultata una forte associazione fra la presenza di precedenti gravidanze accertate, il genotipo HLA-G 14bp D/I e l'inefficacia al MTX. Considerando l'elevata espressione di HLA-G a livello del trofoblasto e il suo coinvolgimento nelle poliabortività, è stato indagato il microchimerismo fetale (fMC), già noto per essere presente nel sangue di donne affette da patologie autoimmuni, come AR e Lupus Eritematoso Sistemico (LES), anche dopo molti anni dalla gravidanza o dall'evento abortivo. Lo studio caso-controllo ha rilevato significativa presenza di fMC maschile nel campione ematico periferico di pazienti lupiche. La sintomatologia sistemica di LES potrebbe giustificare l'elevata presenza di fMC maschile nelle pazienti lupiche rispetto alle pazienti AR. Indagando le biopsie sinoviali di donne affette da AR, non è stata rivelata presenza di fMC maschile, suggerendo il possibile ruolo delle cellule microchimeriche come elementi di supporto e di rescue nel miglioramento della patologia. Sarebbe, dunque, possibile individuare cellule fMC solo nei casi di pazienti con AR stabile o in fase di remissione. Infine, è stata esplorato il profilo epigenetico attraverso analisi di metilazione di LINE-1 e dei geni HLA-G e MTHFR, su soggetti sani di controllo, su pazienti con artrite agli esordi e su pazienti con diagnosi accertata di AR. HLA-G ha evidenziato una significativa ipermetilazione nelle pazienti donne con AR rispetto agli uomini; mentre MTHFR ha rivelato una significativa ipometilazione, gradualmente maggiore a seconda della progressione di AR. In conclusione, i risultati esposti nella presente tesi hanno evidenziato il network di interazioni come importante elemento causativo di insorgenza e risposta terapeutica di AR. Inoltre, il focus sulle pazienti donne affette da AR ha enfatizzato l'applicazione della medicina di genere; infine, lo studio di epigenetica è il primo ad indagare lo stato di metilazione e la progressione di AR, sottolineando l'importanza del contributo ambientale e consentendo una nuova direzione esplorativa.
Riding, S. Barbara. "The arthritic pain experience of children with juvenile rheumatoid arthritis." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27731.
Повний текст джерелаApplied Science, Faculty of
Nursing, School of
Graduate
MAZZONI, MARTA. "VALORE PREDITTIVO DELL’ECOGRAFIA MUSCOLOSCHELETRICA NEI PAZIENTI AFFETTI DA ARTRITE IDIOPATICA GIOVANILE IN REMISSIONE CLINICA." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1046998.
Повний текст джерелаSoula, P. Ch Eugène. "Contribution à l'étude de la migraine." Paris : BIUM, 2004. http://www.bium.univ-paris5.fr/histmed/medica/cote?TPAR1884x035.
Повний текст джерелаZANETTI, ANNA. "The management of patients with rheumatoid arthritis: an overview of obstacles and improvement strategies." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/365542.
Повний текст джерелаRheumatoid arthritis (RA) is, in Italy, the most widespread autoimmune disease with high associated costs for the National Health Service. This disease affects about 0.5-1% of the adult population, mainly of the female gender. Being a degenerative disease, whose damages are frequently irreversible, an early diagnosis as well as an adequate treatment and a high level treatment compliance of the patient, could slow down the worsening of the disease. Furthermore, the possible effects of RA and its treatment on pregnancies and subsequent pregnancy outcomes are not well known. The main objectives of the thesis are therefore: i) to evaluate the adherence to guidelines for the treatment of RA, ii) to evaluate the patient's adherence to RA treatment, iii) to estimate the cost and effectiveness of care provided in specialized clinics for the treatment of RA patients, iv) to analyze pregnancy outcomes and the likelihood of achieving pregnancy in women with RA treated with methotrexate (MTX). The first issue concerned the assessment of how the guidelines of the European Alliance of Associations for Rheumatology (EULAR) for the treatment of RA have been implemented, and the impact of adherence to these guidelines on the probability of hospitalization. The main results of this study showed that patients with excellent adherence to guidelines, when compared with those with low adherence, have a 24% lower risk of hospitalization. The second topic concerned the evaluation of the impact of adherence to treatment with Disease-Modifying Anti-Rheumatic Drugs (DMARDs), the therapy suggested by EULAR, on the achievement of disease clinical remission (defined as a substantial decrease or absence of symptoms). The ELECTRA database, which contains clinical information and information from administrative databases of RA patients treated at the IRCCS Policlinico San Matteo (Pavia), was considered for the analysis. The main finding showed that a 10-unit percentage increase in proportion of days covered by DMARDs is associated with a 10% increase in the likelihood of clinical remission. These results show the importance of monitoring patients in clinical practice to maintain high levels of treatment compliance. The objective of the third theme focused on a cost-effectiveness evaluation, comparing RA patients treated in specialized clinics ("Early Arthritis Clinic" - EAC), with RA patients treated in non-specialized clinics. Two cohorts were recruited, the first one included patients treated in the EAC of the IRCCS Policlinico San Matteo and the other one with patients with RA extracted from the administrative databases of Lombardy region. The main results of this third phase showed that a moderate increase in costs is associated with a very high increase in effectiveness, especially if calculated as length of hospitalizations and as adherence to the EULAR guidelines. These findings could open up new scenarios in RA patient management. The fourth and final topic concerned the impact of treatment with MTX (DMARD suggested by EULAR as the first line of treatment) in RA women, on the likelihood of achieving pregnancy and on pregnancy outcomes. Three cohorts were recruited: women with RA with incident MTX exposure, women with RA without MTX treatment, and women without RA. The main results of this analysis showed that women with RA, especially when treated with MTX, have a lower frequency of pregnancies than women without RA. Furthermore, women treated with MTX have a higher risk of spontaneous abortion (about twice as high) than the other two cohorts.
Cavaciocchi, F. "T CELL SUBTYPES IN MANAGEMENT OF OSTEOPOROSIS WITH BISPHOSPHONATES AND THE AUTOIMMUNE REACTION TO THE COLLAGEN IN RHEUMATOID ARTHRITIS." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/251417.
Повний текст джерелаLO, MONACO Marika. "Relationship between clinical variables and Patient-Reported Outcomes in patients with psoriatic disease." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/499644.
Повний текст джерелаCassone, Giulia. "Caratteristiche cliniche e nuovi orizzonti diagnostico-terapeutici delle vasculiti dei grandi vasi e della interstiziopatia polmonare secondaria ad artrite reumatoide." Doctoral thesis, Università degli studi di Modena e Reggio Emilia, 2022. http://hdl.handle.net/11380/1288753.
Повний текст джерелаAutoimmune rheumatic diseases are chronic diseases with a major health impact worldwide. Their economic and social burden results from a decreased quality of life, lost productivity, and increased costs of health care. Without appropriate approaches to patient management and control of these diseases, this impact can be expected to increase as the population ages. Challenges in studying rheumatic diseases lie in achieving accurate epidemiological data and making efforts to obtain significant progress in terms of early diagnosis, treatment, and management of patients. Section A: Giant-cell arteritis (GCA) is the most common form of vasculitis in patients over 50 years old. Extra-cranic large vessel involvement (LVI) has emerged in recent decades, especially with the development of new imaging tools such as PET-TC, MR-Angiography (MRA) and CT-Angiography (CTA). It is unknown, however, how effective these methods are for assessing disease activity while patients are under treatment. GCA treatment is mainly based on long term use of corticosteroids (GCs). Tocilizumab has recently been approved for the treatment of GCA. However, it is often use in combination with GCs, with subsequent high risk of side effects. Starting from these considerations, we underwent a monocentric observational study to evaluate clinical and functional/morphological imaging variations in a series of patients with GCA treated with ultra-short corticosteroids (GCs) and tocilizumab (TCZ) s.c. We also evaluated effectiveness and safety of TCZ monotherapy as a maintenance treatment in GCA. In our preliminary results, radiologic tools seem to be useful methods for assessing disease activity in GCA patients during treatment. TCZ demonstrated a good safety profile in patients with GCA, however its potential effect in stabilize or resolve large vessels inflammation without the concomitant use of GCs has yet to be demonstrated in large randomized clinical trials. Section B: Rheumatoid arthritis (RA) is the most common chronic inflammatory disease, affecting 0.5%-1% of the population worldwide. Interstitial lung disease (ILD) is the most common and serious complication of lung involvement in RA. All the available studies about the prevalence of ILD in AR are retrospective, with small series of patients and numerous biases, and therefore not reliable. Moreover, this complication is often underrated, particularly in its earliest stages. An early diagnosis is challenging, and the increase of the opportunities to diagnose ILD could improve the quality of life of patients and decrease the mortality and the high utilization of healthcare resources. Although lung involvement represents the second cause of death in RA patients, there are no randomized screening approaches or management guidelines. Several therapeutic agents have been suggested for the treatment of RA-ILD, but nowadays there are no randomized controlled clinical trials to support therapeutic guidelines and treatment of RA-ILD is still based on empirical approaches. In this background, aims of this study project were: -to review the current literature on the treatment of ILD in RA patients and discuss the unsolved problems regarding this challenging patient cohort, even suggesting a framework for their management and analyzing the evolution of RA-ILD in patients treated with tocilizumab and abatacept; -to investigate the usefulness of detecting velcro crackle in lung sounds by analyze them using a suitably developed algorithm, as an early screening of RA-ILD; -to perform an international prospective multicenter observational study to evaluate incidence and prevalence of ILD in patients with RA.
Guillot, Xavier. "Effets thérapeutiques et anti-inflammatoires de la cryothérapie dans les rhumatismes inflammatoires." Thesis, Besançon, 2016. http://www.theses.fr/2016BESA3009/document.
Повний текст джерелаCryotheapy i widely and empirically used in an adjuvant setting in inflammatory rheumatic diseases, with a low level of evidence. We performed a systematic review of the literature and, by pooling data from 6 non-controlled studies, we could show that local cryotherapy (local or whole-body cryotherapy) applaied twice a day for 7-15 days significantly reduced the pain VAS and the DAS28 activity score in rheumatoid arthritis. Furthermore, local cryotherapy (ice packs or cold gas) showed significantly greater intra)class effect-sizes compared to whole-body cryotherapy. The aim of this work was to measure the effects of local cryotherapy on pain, synovial and systemic inflammation in arthrici patients and in the murine model of adjuvant-induced arthritis. First, in the CDRI and ALGGAR randomized studies, we evaluated the effects of 2 local cold applications (ice versus cold gas) on pain, power Doppler activity and intra-joint cytokine protein levels in 46 patients suffering from non-septic knee arthritides. Contralateral arthritic knee were used as control. Secondly, we studied the in vitro effects of mild hypothermia (30°C for 2 hours) on cytokine protein expression in a model of cultured arthritic rat patellae. Thidly, we studied the in vitro effects of sub-chronically applied ice or cold gas (twice a day for 14 days versus non-treated arthritic controls) on the arthritis score, the ankle diameter, pro-inflammatory cytokine gene transcription levelsin hind paws (Q-RT-PCR) and cytokine plasma protein levelx (Multiplex and ELISA) after 14 days of treatment. In the CDRI study, local cryotherapy (ice and cold gas) significantly reduced the pain VAS and the power Doppler score in treated kness, and these effects remained significant the day afetr 2 cold applicaitions. In an intermediate analysis of the ALGGAR study results, by pooling the 2 treatment groups, we could show significant decreases in IL-6 protein, IL-1β and VEGF synovial fluid protein levels after 2 cold applicatios. In arthritic rat patella explangt culture experiments, punctual hypothermia significantly reduced IL-6 protein levels. In vivon ice was more efficient on the clinical parameters and better tolerated compared to cold gas. Both techniques significantly reduced IL-6, IL-17A ans IL-1β gene transcription levels in hind paws after 14 days of treatment. Both techniques redcued IL-17A plasma protein levles, while ice also reduced IL-6 and VEGF plasma protein levels. Conversely, we observed no effect of local cryotherapy on the TNF-α pathway, neither in patients nor in our animal model. Here we demonstrate for the first time therapeutic and anti-inflammatory effet-cts of local cryothepary in arthritis. The biological effects were IL-6/IL-17-driven and TNF-α independent. Further studies will help elucidate the underlying molecular mlechanisms involved and detemrine whether local cryotherapy might be a safer alternative to NSAIDs ans corticosteroids in inflammatory rheumatic diseases
Sukubo, N. G. "NO CODING RNAs IN MACROPHAGE POLARIZATION: THE RELEVANCE OF THE "JUNK" RNA." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/365870.
Повний текст джерелаMartire, Delphine. "Potentiel thérapeutique des lymphocytes régulateurs de type 1 (Tr1) dans l'arthrite expérimentale." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON1T025.
Повний текст джерелаObjectives : Regulatory T (Treg) cells play a crucial role in preventing autoimmune diseases and are an ideal target for therapies to suppress inflammation in an antigen-specific manner. Type 1 Treg cells (Tr1) are defined by their capacity to produce high levels of IL10, which contributes to their ability to suppress pathological immune responses in several settings. The aim of my PhD was to evaluate the therapeutic potential of collagen type II-specific Tr1 (Col-Treg) cells in two models of rheumatoid arthritis (RA) in mice. Methods : Col-Treg clones were isolated and expanded from Collagen-specific TCR transgenic mice. Their cytokine secretion profile and phenotype characterization were studied. The therapeutic potential of Col-Treg cells was evaluated after adoptive transfer in collagen-antibodies- and collagen-induced arthritis models. The in vivo suppressive mechanism on effector T cell proliferation was also investigated. Results : Col-Treg clones are characterized by a cytokine profile (IL10highIL4negIFN-γint) and mediate contact-independent immune suppression. They also share with natural Tregs high expression of GITR, CD39 and Granzyme B. Single infusion of Col-Treg cells reduced incidence and clinical symptoms of arthritis both in preventive and curative settings, with a significant impact on collagen type II antibodies. Importantly, injection of antigen-specific type 1 Treg cells decreases significantly the proliferation of antigen-specific effector T cells in vivo. Conclusion : Our results demonstrate the therapeutic potential of Col-Treg cells in two models of RA, providing evidence that Col-Treg could be an efficient cell-based therapy for RA patients refractory to current treatments
Lozano, Claire. "Rôle de mir-342-3p dans l'hétérogénéité fonctionnelle des ostéoclastes et implication dans l’arthrite auto-immune." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT016.
Повний текст джерелаMicroRNAs (miRNAs) are small, single-strand non-coding RNAs that negatively regulate gene expression at the post-transcriptional level in many cellular processes. They play a key role in the regulation of osteoclastogenesis, a process of cell differentiation that leads to the formation of osteoclasts (OCs). OCs are multinucleated cells located in bone tissue that derived from myeloid precursors. OCs are the only cells capable of bone resorption, which role is essential to bone homeostasis and turnover. However, they actively participate in bone erosion in rheumatoid arthritis (RA), an autoimmune disease characterized by chronic joint inflammation associated with destruction of cartilage and bone. Based on their immunological properties, two OC subsets have been identified, the so called tolerogenic OCs (t-OCs) and inflammatory OCs (i-OCs). Recent studies have shown that the i-OCs associated with arthritis exclusively derive from circulating Ly6Chigh precursors that infiltrate inflamed joints. Combining miRNome and RNA-Seq analyses of t-OC and i-OC subsets, I aimed at identifying miRNAs markers specific for each subset and associated biological pathways. Among the miRNAs associated with i-OCs, I identified miR-342-3p, neither described yet in osteoclastogenesis or in arthritis. I demonstrated that miR-342-3p has a pro-osteoclastic effect in vitro by supporting the early phase of osteoclastogenesis, through the control of survival and motility of the precursors. I optimized the delivery of miR-342-3p agonist or neutralizing molecules in the precursors of i-OCs using the mouse model of autoimmune arthritis (K/BxN serum-transfer arthritis, STA) and the cationic liposome DMAPAP/DOPE. I showed that the systemic or intra-articular administration of miR-342-3p lipoplex selectively targets blood and joint inflammatory Ly6Chigh monocytes, and that in vivo neutralization of miR-342-3p in Ly6Chigh OC precursors of STA mice increased Adam17 expression. I identified Adam17 as a novel target for miR-342-3p. Overall, my data indicate that the in vivo modulation of miR-342-3p expression in i-OC precursors could be a potential therapeutic strategy to reduce bone erosion in arthritis
Presumey, Jessy. "Cibler les monocytes inflammatoires par ARNi pour une immunothérapie innovante des maladies autoimmunes." Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON1T017/document.
Повний текст джерелаInflammatory mouse Ly6Chigh monocyte subset and its human counterpart, defined as CD14+ CD16-, play key roles in the initiation and chronicization of immune-mediated inflammatory disorders (IMID). Deleterious effects of monocytes led to the development of therapeutic strategies aiming at depleting them or preventing their recruitment to inflamed tissues. However, these methods are poorly specific with weak efficacy considering the high number of inflammatory monocytes and their marked level of activation. The need for developing new therapeutic approaches is obvious. The aim of my thesis was to characterize selective delivery of a siRNA-containing lipid formulation to the Ly-6Chigh monocyte population and at evaluating the therapeutic potential of this targeted strategy. Using the cationic lipid-based DMAPAP vehicle for in vivo RNAi-mediated gene silencing, my work allowed demonstrating, in a preclinical mouse model of arthritis, the efficacy to inhibit master genes of inflammation specifically within Ly-6Chigh monocytes upon systemic injection. Reduced disease severity in mice was associated with an overall systemic immunomodulation of the pathogenic T cell populations and led to defective mobilization of immune cells to arthritic joints. Importantly, the formulation was successfully optimized in a perspective of clinical application and the targeting of human CD14+CD16- inflammatory monocytes was validated ex vivo. Overall, my findings demonstrate that the silencing of a key gene within Ly-6Chigh monocytes is a promising strategy for future therapeutic intervention in the context of IMID and reinforces the pivotal role of Ly-6Chigh monocytes in inflammatory processes
Vugler, Alexander David. "Predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunity." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494617.
Повний текст джерелаPaquet, Joseph. "Potentialités anti-inflammatoires de l'inhibition génomique et transcriptionnelle du TNF-[alpha] par une approche de type oligonucléotidique." Thesis, Nancy 1, 2010. http://www.theses.fr/2010NAN10067/document.
Повний текст джерелаTumor necrosis factor alpha (TNF-[alpha]), a pro-inflammatory cytokine, plays a key role in the pathogenesis of many inflammatory diseases, including arthritis. Neutralization of this cytokine by anti-TNF-[alpha] antibodies has shown its efficacy in rheumatoid arthritis and is now widely used. Nevertheless, some patients currently treated with anti-TNF-[alpha] remain refractory or become non-responder to these treatments. In this context, there is a need for new or complementary therapeutic strategies. Triplex forming oligonucleotides (TFO) can inhibit gene expression with high sequence-specificity by interacting with the DNA double-strand. In this study, we investigated if an anti-TNF-[alpha] TFO had a therapeutic activity on inflammatory processes in vitro and in vivo, as judged from effects on two rat arthritis models. This TFO interacted with the TNF-[alpha] gene promoter, and its inhibitory activity was verified and compared to that of siRNA in vitro. A local intra-articular preventive injection of TFO in both acute and chronic arthritis models significantly reduced the development of the disease. Furthermore, the TFO efficiently blocked synovitis and cartilage and bone destruction in the joints. The results presented here provide the first evidence that gene targeting by anti-TNF-[alpha] TFO modulates arthritis in vivo, thus providing proof of concept that it could be used as therapeutic tool for TNF-[alpha]-dependent chronic inflammatory disorders
Hablot, Julie. "Liens entre inflammations articulaire et digestive : étude expérimentale chez la souris et contribution de l’immunité mucosale." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0095/document.
Повний текст джерелаNumerous type 3 immune cells (Th17 and ILC3) are physiologically located in lamina propria of the intestine. Microbial agents within the gut shape the immune system to make it efficient against threats but peaceful with commensals. Recent studies demonstrated changes in gut microbiota composition (dysbiosis) in chronic inflammatory rheumatism. These results suggest a role for mucosal immunity alteration in articular inflammation occurrence. Indeed, some type 3 immune cells once activated by microbiota, are thought to migrate to joints, involving notably chemokines receptors. Transcription factor RORγt, the master regulator of type 3 immune cells, could be negatively regulated by nuclear receptor PPARγ. Using experimental murine models, we studied the consequence of PPARγ deficiency and consequence of the chemokine receptor CCR3 inhibition on the joint-gut axis. Firstly, we demonstrated that experimental colitis induces microbiota changes, delays and reduces collagen-induced arthritis severity. Secondly, we showed that PPARγ deficient mice display spontaneous joint inflammation associated with abnormal type 3 distribution within the gut. Dysbiosis with enrichment in facultative anaerobic Enterobacteriaceae was found in these mice. Fecal microbiota transfer demonstrated this microbiota is non-arthritogenic. Finally, we demonstrated that CCR3 inhibition has profound anti-arthritic potencies associated with changes in leukocytes distribution within the joint-gut axis
Quentin, Julie. "Immunomodulation de l'arthrite expérimentale par les cellules dendritiques tolérogènes." Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON1T018/document.
Повний текст джерелаTolerogenic dendritic cells for immumodulation in experimental arthritis.Dendritic cells (DCs) are the most potent antigen-presenting cells that play critical roles in the initiation and regulation of immune responses. Based on their tolerogenic properties, DCs offer potential as therapeutic tools to ameliorate or prevent graft rejection or graft-versus-host disease, or to treat autoimmune disorders.The objectives of my PhD consisted to:- reinforce the tolerogenic potential of DCs by in vitro handling.- assess the capacity of such tolerogenic DCs to induce a protective response in experimental autoimmune arthritis- identify cellular and molecular mechanisms implied in the tolerogenic DCs-induced protectionOur results suggest that, in contrast with conventional DCs, the rapamycin-conditioned iDCs maintain their tolerogenic potential upon injection in inflammatory settings and are able to dampen an already Th1-primed immune response, conferring a protection from arthritis. The protection of the mice was associated with an expansion of the IL-10-secreting CD49b+ Treg in the spleen and liver of the injected mice and a decrease of the Th1 immune response. These results underscore the therapeutic potential of tolerogenic DCs in an established autoimmune disease as well as the anti-inflammatory potential of the CD49b+ Treg cell population induced following DC vaccination
Spilis, Angelica Abby. "Dancing With Arthritis." Master's thesis, Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/327134.
Повний текст джерелаM.A.
This Master of Arts thesis is based on research that I conducted on dancers who have the auto-immune disease of Rheumatoid Arthritis. Rheumatoid Arthritis is a long-term autoimmune disease that causes inflammation in the joints and the surrounding tissues. Dancers with arthritis feel pain the joints that can be minor or severe, depending on how they are moving their bodies. This research investigates how dancers with an arthritic body can dance without the experiencing pain in their joints. Arthritis impairs movement because it is a disease that affects the joints. In this thesis, I created movements that could enable arthritic dancers the opportunity to continue dancing. I have identified a movement vocabulary, movement methods, and strategies for arthritic dancers who want and need to move with minimal pain. Movements have been created specifically for the arthritic body. I use my own experiences and challenges as an arthritic dancer to inform this study. My experiences helped me to create movements specifically for arthritic dancers because I am an advocate for those who suffer from arthritis.
Temple University--Theses
Hermann, Kay-Geert. "Die rheumatoide Arthritis." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/14542.
Повний текст джерелаMultimedia - word of the year 1995 in Germany - is a popular term cropping up in all areas of society. Universities, too, hope to improve the quality of teaching and to cut costs by introducing computer-based forms of learning. Following initial attempts in the sixties, a new aspect introduced in the nineties was the life-like multimedia simulation of decision-making situations. In medicine, there still is a lack of German-language software packages in rheumatology. The aim of the present project was to develop a multimedia compendium on rheumatoid arthritis for teaching at the university and postgraduate level. The system was intended to serve both as an electronic work of reference and as a basis for interactive slide presentations. Using the authoring tool Macromedia Director on an Apple Macintosh computer, a CD-ROM was developed that can be run on Macintosh and Windows computers alike. The largest part of the multimedia compendium now available (31% of the screen pages) is dedicated to the description of the symptoms of rheumatoid arthritis and examination techniques. Other main areas are pathogenesis (19%), imaging modalities (14%), differential diagnoses (11%), therapy (10%), and laboratory tests (7%). Videos and animations serve to illustrate cellular processes and to summarize the clinical examination techniques. Catalogues of established criteria for electronic media were adhered to during development to assure quality. A simultaneously performed formative evaluation yielded initial results about the practicability and stability of the program but cannot replace a thorough summative evaluation. Multimedia textbooks such as the compendium presented here are ideal supplements to classical textbooks in conventional teaching, providing a rapidly accessible knowledge base for problem-oriented training. However, the results achieved with computer-based learning tools available for optional use at teaching centers have so far lagged behind expectations. It remains to be discussed to what extent the advantages of multimedia technology can save both cost and time by being selectively integrated into the curriculum at German universities.
Nziza, Nadege. "Le rôle des cellules myéloïdes et microARNs dans l'arthrite juvénile." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT014/document.
Повний текст джерелаJuvenile idiopathic arthritis (JIA) is a heterogeneous group of chronic inflammatory rheumatism affecting children under 16 years of age. This inflammatory disorder of unknown origin is characterized by arthritis lasting more than 6 weeks in the absence of treatments.In order to highlight mechanisms involved in the pathophysiology of JIA, an inclusion of patients suffering from septic arthritis, another form of juvenile arthritis, was performed. In parallel, comparative studies between the peripheral blood (PB) and the synovial fluid (SF) of patients with JIA were carried out in order to search for mechanisms specific of joint disturbances.We focused on monocytes and dendritic cells (DCs) subsets as well as the expression patterns of microRNAs (miRNAs) in the PB and SF of patients. These different biological markers are known to play a major role both in the regulation of inflammation and the pathogenesis of inflammatory diseases.Analysis of miRNA expression by a high-throughput sequencing approach followed by RT-qPCR validation revealed specifically deregulated miRNAs in JIA compared to AS. In addition, the phenotypic characterization of myeloid cell subpopulations showed an accumulation and activation profile specific of JIA cells. Overall, this project allowed me to identify different cellular and molecular actors that might be involved in the pathophysiology of JIA
Matthee, Pierre Armand. "The quality of life of arthritis patients taking biologic arthritis medication." Diss., University of Pretoria, 2014. http://hdl.handle.net/2263/46176.
Повний текст джерелаDissertation (MSW)--University of Pretoria, 2014.
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Social Work and Criminology
MSW
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Vingsbo, Lundberg Carina. "Chronic autoimmune arthritis in rats pathogenesis and genetic factors /." Lund : Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/68945081.html.
Повний текст джерелаGibbon, Wayne William. "Imaging in inflammatory arthritis : a multidisciplinary team approach /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18870.pdf.
Повний текст джерелаGoertz, Christine [Verfasser], and Stephan [Gutachter] Meller. "Evaluation verkürzter MRT-Scores bei Patienten mit Rheumatoider Arthritis (Rheumatoid Arthritis MR Imaging Score (RAMRIS)) und Psoriasis-Arthritis (Psoriatic Arthritis MR Imaging Score (PsAMRIS)) / Christine Goertz ; Gutachter: Stephan Meller." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1233007572/34.
Повний текст джерелаCalander, Ann-Marie. "Proteases in staphylococcal arthritis /." Göteborg : Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, Göteborg University, 2007. http://hdl.handle.net/2077/2584.
Повний текст джерелаUlfgren, Ann-Kristin. "Cytokines in rheumatoid arthritis /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3823-7/.
Повний текст джерелаDeLaura, Angela. "Rheumatoid arthritis : an overview /." Online version of thesis, 1989. http://hdl.handle.net/1850/11502.
Повний текст джерелаCruwys, Simon Charles. "Neurogenic influences on arthritis." Thesis, Queen Mary, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243318.
Повний текст джерелаEdwards, Bryan Michael. "Collagen epitopes in arthritis." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265003.
Повний текст джерелаThomson, W. "Immunogenetics of rheumatoid arthritis." Thesis, University of Manchester, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383908.
Повний текст джерелаBodman, Katherine Birgitta. "IgG glycoforms in arthritis." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283129.
Повний текст джерелаKapoor, Sabrina Reenu. "Metabolomics of inflammatory arthritis." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5251/.
Повний текст джерелаOlinik, O. Yu. "Psoriatic arthritis and hyperuricemia." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19621.
Повний текст джерелаKalla, Asgar Ali. "Osteoporosis in rheumatoid arthritis." Master's thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/26297.
Повний текст джерелаToms, Tracey. "Dyslipidaemia in rheumatoid arthritis." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/dyslipidaemia-in-rheumatoid-arthritis(e7808bd7-52e6-40a0-84cb-e4aadbf7505c).html.
Повний текст джерелаCourties, Gabriel. "Développement d'Immunothérapies anti-inflammatoires de la polyarthrite rhumatoïde par ARN interférence dans un modèle murin d'arthrite." Thesis, Montpellier 1, 2010. http://www.theses.fr/2010MON1T016.
Повний текст джерелаRheumatoid arthritis (RA) is the most frequent chronic inflammatory systemicautoimmune disease that remains a major medical challenge as the exact causes of the disease are not completely elucidated. The principal treatment strategies arebased on the inhibition of TNF-α, one of the major inflammatory cytokine in RA.Although risk and benefit analyses are in favour of the use of monoclonal antibodiesagainst TNF-α, the most currently used biotherapy, they are not devoid from multipleside effects. The search for new therapeutic targets is essential to proposealternative approaches to non responders to such biotherapies. The possibility to interfere in the mechanisms responsible for regulating mRNA stability andeffectiveness of the translational machinery also present a therapeutic benefitsuperior to current biologic therapies based on inhibition secreted proteins(antibodies or soluble receptors). Such approach however requires developingvectors that efficiently transduced the specific cell type producing the targeted gene.Projects of my PhD fellowship have included both the development of gene therapyvehicles for RNAi-based intervention in experimental mouse models of arthritis andevaluation of novel candidate genes for alternative anti-inflammatory therapy in RA
Holm, Barbro. "Pathogenetic studies of adjuvant-induced arthritis /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-347-3/.
Повний текст джерелаRoy, Josée. "Stratégies d'adaptation à l'arthrite chronique chez les octogénaires." Sherbrooke : Université de Sherbrooke, 2002.
Знайти повний текст джерелаHawtree, Sarah. "Investigation of the roles of histone deacetylases in rheumatoid arthritis and collagen-induced arthritis." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/10169/.
Повний текст джерелаCourbon, Guillaume. "Etudes cinétiques de la perte osseuse au cours de l'inflammation articulaire chronique." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSES053.
Повний текст джерелаRheumatoid arthritis is a chronic inflammatory joint disease which is accompanied by synovial inflammation and subchondral bone loss. This thesis focused on early bone loss in arthritis and bone-associated inflammatory mechanisms. The preclinical stages of arthritis have been investigated through animal models. Systemic bone loss was studied and correlated to local bone loss. Proof of concept for early bone loss was obtained in several studies. This loss predicted arthritis severity and started before clinical observation of joint inflammation. Early bone loss was associated with cortical and trabecular bone microarchitecture changes. Associated mechanisms involved at the same time the activation of bone resorption and the inhibition of bone formation. A systemic bone loss was also detected, correlating with the local loss. In the mouse model with chronic expression of tumor necrosis factor (TNF), axial bone loss resulted from an increase in bone resorption without affecting osteoclast activity, suggesting that inhibition of TNF explain the re-ossification in axial forms of SpA. Oral infection with Porphyromonas gingivalis induced systemic arthritis in rats over eight months, increasing citrullinated anti-peptide antibodies levels and bone resorption. In a translational approach, two therapeutic candidates for arthritis treatment have shown regulatory effects on joint destruction associated with a protective effect on the subchondral bone. These results reinforced the concept of early bone loss in arthritis, with the involvement of osteoimmune signalling. Blockade strategies of bone resorption and bone formation inhibition might be developed in the chronic inflammatory joint diseases, and their use might be considered in the early stages of disease
Koufany, Meriem. "Étude de la contribution des récepteurs activés par les proliférateurs de peroxysomes en physiopathologie articulaire." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0230/document.
Повний текст джерелаPeroxisome proliferator-activated receptors (PPARs) are transcription factors implicated in lipid metabolism and glucose tolerance. Once activated by specific agonists, PPARs control inflammation associated with numerous diseases, notably Rheumatoid arthritis. The first study presented here aim to compare the anti-arthritic potency of two high-affinity synthetic agonists for PPARα and PPARγ in an experimental model. Then we focused on the effect of pioglitazone, a high-affinity synthetic agonists for PPARγ, and demonstrated that a per os treatment with this agonist not only reduced experimental arthritis but also inhibited partly inflammation-related bone loss by preserving bone microarchitecture. We pointed out that PPARγ, on one hand, regulated local and systemic expression of interleukine-17 (IL-17) and RANKL and on the other hand, inhibited expression of transcription factor RORγt, a main regulator of IL-17/Th17 pathway. Study of mice deficient for PPARγ confirmed its major role in the development of the arthritic process since these mice developed spontaneously arthritis. Of interest arthritis in these mice is associated with increased number of synovial mast cells able to produce IL-17 and their own differenciation factor, the SCF. Finally, we discussed the possible link between inflammatory arthritis and mastocytosis in a case report of a patient suffering from rheumatoid arthritis concomitant to systemic mastocytosis
Iaquinta, Monica L. "The phenomenological lived experience of rheumatoid arthritis." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=1842.
Повний текст джерелаde, Souza Patricia Regina Soares. "GPR40 expression and function in immune cells and experimental arthritis." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25975.
Повний текст джерелаFabre, Annie-Claude. "Notre expérience sur les arthrites septiques des membres : à propos de 58 observations." Bordeaux 2, 1992. http://www.theses.fr/1992BOR2M171.
Повний текст джерелаSchumann, Frank. "Autoantigene bei der rheumatoiden Arthritis." [S.l.] : [s.n.], 2004. http://www.diss.fu-berlin.de/2004/199/index.html.
Повний текст джерелаSchnez, Amelie. "Standardisierte Gelenkuntersuchung bei rheumatoider Arthritis." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-142212.
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