Дисертації з теми "Applications in life sciences"
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Shrestha, Tej Bahadur. "Heterocycles for life-sciences applications and information storage." Diss., Kansas State University, 2010. http://hdl.handle.net/2097/13540.
Повний текст джерелаDepartment of Chemistry
Stefan H. Bossmann
The photochromic spirodihydroindolizine/betaine (DHI/B) system has been reinvestigated applying picosecond, microsecond, stationary absorption measurements, and NMR-kinetics. The first surprise was that the electronic structure of the betaines is quite different than commonly assumed. The photochemical ring-opening of DHIs to betaines is a conrotatory 1,5 electrocyclic reaction, as picosecond absorption spectroscopy confirms. The (disrotatory) thermal ring-closing occurs from the cisoid betaine. The lifetime of the transoid betaine is 60 s at 300 K, whereas the lifetime of the cisoid isomer is of the order of 250 microseconds. According to these results, the electrocyclic back reaction of the betaines to the DHI is NOT rate determining, as previously thought, but the cisoid-transoid-isomerization of the betaine. Although the presence of a second nitrogen atom increases the photostability of the spirodihydroindolizine-pyridazine/betaine-system remarkably, the photochemical reaction mechanism appears to be exactly the same for spirodihydroindolizine-pyridazine/betaine-system. A nondestructive photoswitch or an information recording systems has been explored using styryl-quinolyldihydroindolizines. Both isomers DHI and betaine are fluorescent. When the blue betaine is stabilized in a thin polymethyl methacrylate (PMMA) matrix, it is stable for several hours even in room temperature and very stable at 77K. Although irradiation of visible light = 532 nm allows the photo-induced reaction of the Betaine back to the DHI, a nondestructive read-out can be performed at λ = 645 nm upon excitation with λ = 580 nm. Image recording (write) and read-out, as well as information storage (at 77K) have been demonstrated. Charged and maleimide-functionalized DHI/B systems have beed synthesized for use as photochemical gates of the mycobacterial channel porin MspA. Positively charged and maleimide functionalized DHI groups that were attached to the DHI/B-system permit the binding of the photoswitch to selective positions in the channel proteins due to the presence of a cysteine moiety. An inexpensive new method for the large scale synthesis of coelenterazine is developed. A modified Negishi coupling reaction is used to make pyrazine intermediates from aminopyrazine as an economical starting material. This method permits the use of up to 1g coelenterazine per kg body weight and day, which turns the renilla transfected stem cells into powerful light sources.
Elliott, Victoria Louise. "Novel applications of ICP-MS in the life sciences." Thesis, University of Sheffield, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427243.
Повний текст джерелаDargatz, Christiane. "Bayesian Inference for Diffusion Processes with Applications in Life Sciences." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-121361.
Повний текст джерелаThorne, David. "A semantic architecture for visualisation applications in the life sciences." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.705542.
Повний текст джерелаSingh, Gurpreet. "Nanodevices for applications in life sciences and engineering; Fabrication and mechanical characterization." Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3288721.
Повний текст джерелаSource: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7629. Advisers: Roop L. Mahajan; J Richard McIntosh. Includes supplementary digital materials.
Kupferschmidt, Natalia. "Toxicological and Immunomodulatory Properties of Mesoporous Silica Particles : Applications in Life Sciences." Doctoral thesis, Uppsala universitet, Nanoteknologi och funktionella material, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-195904.
Повний текст джерелаLin, Jing [Verfasser]. "Electrochemical microbiosensors and improved immobilization strategies for life sciences applications / Jing Lin." Ulm : Universität Ulm, 2019. http://d-nb.info/1200994477/34.
Повний текст джерелаNilsson, Roland. "Statistical Feature Selection : With Applications in Life Science." Doctoral thesis, Linköping : Department of Physcis, Chemistry and Biology, Linköping University, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/tek1090s.pdf.
Повний текст джерелаSudirman, Azizahalhakim. "Increased Functionality of Optical Fibers for Life-Science Applications." Doctoral thesis, KTH, Kvantelektronik och -optik, QEO, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-145319.
Повний текст джерелаQC 20140516
Ghosh, Arindam [Verfasser]. "Single Molecule Fluorescence Spectroscopy and Imaging: Advanced Methods and Applications in Life Sciences / Arindam Ghosh." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2021. http://d-nb.info/1235222748/34.
Повний текст джерелаPocheville, Arnaud. "LA NICHE ÉCOLOGIQUE: CONCEPTS, MODÈLES, APPLICATIONS." Phd thesis, Ecole Normale Supérieure de Paris - ENS Paris, 2010. http://tel.archives-ouvertes.fr/tel-00715471.
Повний текст джерелаHinneburg, Alexander [Verfasser], Stefan [Akademischer Betreuer] Brass, Thomas [Akademischer Betreuer] Seidl, and Myra [Akademischer Betreuer] Spiliopoulou. "Text mining and applications in life sciences / Alexander Hinneburg. Betreuer: Stefan Brass ; Thomas Seidl ; Myra Spiliopoulou." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2011. http://d-nb.info/1025303172/34.
Повний текст джерелаBorghi, Francesco <1984>. "Flow Field–Flow Fractionation for size analysis and characterization of nanoparticles for applications in Life Sciences." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6446/.
Повний текст джерелаHinneburg, Alexander [Verfasser], Stefan Akademischer Betreuer] Brass, Thomas [Akademischer Betreuer] Seidl, and Myra [Akademischer Betreuer] [Spiliopoulou. "Text mining and applications in life sciences / Alexander Hinneburg. Betreuer: Stefan Brass ; Thomas Seidl ; Myra Spiliopoulou." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2011. http://nbn-resolving.de/urn:nbn:de:gbv:3:4-7603.
Повний текст джерелаFournier, I. "Développements en Imagerie par Spectrométrie de Masse MALDI et Applications aux Problématiques Biologiques." Habilitation à diriger des recherches, Université des Sciences et Technologie de Lille - Lille I, 2005. http://tel.archives-ouvertes.fr/tel-00167305.
Повний текст джерелаCependant, afin d'augmenter encore la potentialité de cette technologie, des développements restent encore à effectuer. Les recherches menées ont donc plus particulièrement portées sur ces développements.
En particulier, la recherche et l'étude de nouvelles matrices plus adaptées à l'analyse directe de tissu en MALDI sont particulièrement importantes. Dans ce contexte, certaines matrices ioniques se sont révélées particulièrement adaptées aux tissus en permettant d'obtenir une plus grande intensité du signal, un plus grand nombre de composés détectés, de bonnes performances en mode négatif, une grande homogénéité de cristallisation, une grande stabilité sous vide et une faible ablation de matériel consécutivement à l'irradiation laser. Dans un autre aspect, le traitement préalable des tissus permet également une amélioration de la qualité spectrale et des performances d'études structurales en mode MS/MS. Se sont révélés particulièrement intéressants les traitements des tissus aux solvants organiques et les digestions enzymatiques et en particulier pour les tissus conservés en blocs de paraffine après fixation.
D'autre part l'étude de la répartition des ARNm au sein des tissus est un développement crucial afin d'obtenir des images de colocalisation transcriptome/protéome. Est proposé dans ce travail un nouveau concept permettant de réaliser ces images, basé sur une analyse indirecte des ARNm, au travers de l'utilisation d'un groupement photoclivable relié à un peptide marqueur de séquence connue qui sera détecté.
Enfin, l'ensemble de ces développements trouve de nombreuses applications dans le domaine de la biologie et notamment dans le cadre de pathologies tel que le cancer de l'ovaire.
Dell'Aguzzo, Paolo. "The secret life of software applications." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amslaurea.unibo.it/7405/.
Повний текст джерелаWollweber, Merve [Verfasser]. "Multimodal spectroscopy for application in the life sciences / Merve Wollweber." Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2018. http://d-nb.info/1192440471/34.
Повний текст джерелаSmus, Justyna Paulina. "Application of enhanced Raman techniques in life sciences and biomedicine." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/409721/.
Повний текст джерелаVestberg, Robert. "Dendron decorated chromophores for optical power limiting applications." Doctoral thesis, Stockholm, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-78.
Повний текст джерелаBylesjö, Max. "Latent variable based computational methods for applications in life sciences : Analysis and integration of omics data sets." Doctoral thesis, Umeå universitet, Kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1616.
Повний текст джерелаFunktionsgenomik är ett forskningsområde med det slutgiltiga målet att karakterisera alla gener i ett genom hos en organism. Detta inkluderar studier av hur DNA transkriberas till mRNA, hur det sedan translateras till proteiner och hur dessa proteiner interagerar och påverkar organismens biokemiska processer. Den traditionella ansatsen har varit att studera funktionen, regleringen och translateringen av en gen i taget. Ny teknik inom fältet har dock möjliggjort studier av hur tusentals transkript, proteiner och små molekyler uppträder gemensamt i en organism vid ett givet tillfälle eller över tid. Konkret innebär detta även att stora mängder data genereras även från små, isolerade experiment. Att hitta globala trender och att utvinna användbar information från liknande data-mängder är ett icke-trivialt beräkningsmässigt problem som kräver avancerade och tolkningsbara matematiska modeller. Denna avhandling beskriver utvecklingen och tillämpningen av olika beräkningsmässiga metoder för att klassificera och integrera stora mängder empiriskt (uppmätt) data. Gemensamt för alla metoder är att de baseras på latenta variabler: variabler som inte uppmätts direkt utan som beräknats från andra, observerade variabler. Detta koncept är väl anpassat till studier av komplexa system som kan beskrivas av ett fåtal, oberoende faktorer som karakteriserar de huvudsakliga egenskaperna hos systemet, vilket är kännetecknande för många kemiska och biologiska system. Metoderna som beskrivs i avhandlingen är generella men i huvudsak utvecklade för och tillämpade på data från biologiska experiment. I avhandlingen demonstreras hur dessa metoder kan användas för att hitta komplexa samband mellan uppmätt data och andra faktorer av intresse, utan att förlora de egenskaper hos metoden som är kritiska för att tolka resultaten. Metoderna tillämpas för att hitta gemensamma och unika egenskaper hos regleringen av transkript och hur dessa påverkas av och påverkar små molekyler i trädet poppel. Utöver detta beskrivs ett större experiment i poppel där relationen mellan nivåer av transkript, proteiner och små molekyler undersöks med de utvecklade metoderna.
Bylesjö, Max. "Latent variable based computational methods for applications in life sciences : Analysis and integration of omics data sets /." Umeå : Chemistry Kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1616.
Повний текст джерелаVishwanathan, S. V. N. "Kernel Methods Fast Algorithms and real life applications." Thesis, Indian Institute of Science, 2003. http://hdl.handle.net/2005/49.
Повний текст джерелаSrilatha, Rondla, and Gande Someshwar. "Security Testing for Web Applications in SDLC." Thesis, Blekinge Tekniska Högskola, Sektionen för datavetenskap och kommunikation, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-2903.
Повний текст джерела+91 8977404640
Cox, Tyler L. "Development of ETSU Student Life Android Application." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/honors/231.
Повний текст джерелаAraiza, Roberto. "The use of interval-related expert knowledge in processing 2-D and 3-D data with an emphasis on applications to geosciences and biosciences /." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2007. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.
Повний текст джерелаAmeli, Reza. "An optogenetic headstage for optical stimulation and neural recording in life science applications." Master's thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26055.
Повний текст джерелаOptogenetics is a new method for controlling the neural activity where light is used to activate or silence, with high spatial and temporal resolution, genetically light-sensitized neurons. In optogenetics, a light source such as a LED, targets light-sensitized neurons. In this work, a light-weight wireless animal optogenetic headstage has been designed that allows multi-channel simultaneous real-time optical stimulation and neural recording. This system has two optogenetic stimulation channels and two electrophysiological reading channels. The optogenetic stimulation channels benefit from high-power LEDs (sinking 150 milliamps) with flexible stimulation patterns and the recorded neural data is wirelessly sent to a computer. The dimensions of the headstage are almost 20×20×15 mm3 and it weighs less than 7 grams. This headstage is suitable for tests on small freely-moving rodents. To the best of our knowledge, this is the first reported fully wireless headstage to offer simultaneous multichannel optical stimulation along with multichannel neural recording capability.
Grant, Joshua Ford. "Electrospun Blends of Polydioxanone and Fibrinogen for Urological Applications." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd/891.
Повний текст джерелаZhang, Qian [Verfasser], and Wolfgang [Akademischer Betreuer] Parak. "Polymer-Coated Inorganic Nanoparticles: Nanotools for Life Science Applications / Qian Zhang. Betreuer: Wolfgang Parak." Marburg : Philipps-Universität Marburg, 2016. http://d-nb.info/1099594251/34.
Повний текст джерелаStankovski, Tomislav. "Tackling the inverse problem for non-autonomous systems : application to the life sciences." Thesis, Lancaster University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654941.
Повний текст джерелаFlantua, Elise. "Applications to enhance participation in everyday life for children/adolescents with ID and ASD : A systematic literature review." Thesis, Jönköping University, HLK, CHILD, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-53663.
Повний текст джерелаDerrien, Thomas. "L'analyse comparée des génomes : applications à l'identification de nouveaux gènes canins." Phd thesis, Université Rennes 1, 2007. http://tel.archives-ouvertes.fr/tel-00656330.
Повний текст джерелаNadrowski, Karin, Daniel Seifarth, Sophia Ratcliffe, Christian Wirth, and Lutz Maicher. "Identifiers in e-Science platforms for the ecological sciences." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-101319.
Повний текст джерелаKing, Barbara M. "A Software Development Life-Cycle Model for Web-Based Application Development." NSUWorks, 2004. http://nsuworks.nova.edu/gscis_etd/636.
Повний текст джерелаHatt, Mathieu. "Détermination automatique des volumes fonctionnels en imagerie d'émission pour les applications en oncologie." Phd thesis, Université de Bretagne occidentale - Brest, 2008. http://tel.archives-ouvertes.fr/tel-00373581.
Повний текст джерелаRoach, Necrisha. "The Development of a Novel Multi-dimensional Product for Wound Healing Applications." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2131.
Повний текст джерелаVom, Braucke Troy S., and tvombraucke@swin edu au. "Establishment of a database for tool life performance." Swinburne University of Technology, 2004. http://adt.lib.swin.edu.au./public/adt-VSWT20050914.085324.
Повний текст джерелаBertrand, Samuel. "Les sidérophores de Scedosporium apiospermum : identification, synthèse et applications." Phd thesis, Université d'Angers, 2009. http://tel.archives-ouvertes.fr/tel-00466113.
Повний текст джерелаDünnbier, Mario [Verfasser]. "Plasma jets for life science applications: characterisation and tuning of the reactive species composition / Mario Dünnbier." Greifswald : Universitätsbibliothek Greifswald, 2015. http://d-nb.info/1080060197/34.
Повний текст джерелаVenkatesan, Aravind. "Application of Semantic Web Technology to Establish Knowledge Management and Discovery in the Life Sciences." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for biologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-24074.
Повний текст джерелаSemantic Systems Biology
Seguin, Johanne. "Caractérisation de modèles de tumeurs murines et leurs applications en thérapie anti-angiogénique vectorisée." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00836310.
Повний текст джерелаKennedy, Caroline A. "Learning and Application of Range Management Innovations Among Ranchers in West-Central Colorado." DigitalCommons@USU, 2005. https://digitalcommons.usu.edu/etd/7430.
Повний текст джерелаToth, Kalman. "Fonctionnalisation d' (endo)fullerène : de la science des matériaux aux applications biomédicales." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00862768.
Повний текст джерелаVila, Roa Eva Graciela. "Evaluation of Pigments from a Purple Variety of Atriplex hortensis L. for Use in Food Applications." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7436.
Повний текст джерелаBARRA, Vincent. "Fusion d'images 3D du cerveau - Etude de modèles et applications." Phd thesis, Université d'Auvergne - Clermont-Ferrand I, 2000. http://tel.archives-ouvertes.fr/tel-00005976.
Повний текст джерелаOrtiz, Cano Hector Genaro. "Pre-Columbian Cultivation of Agave Species Through Rock Mulching: Potential for Modern Applications." BYU ScholarsArchive, 2021. https://scholarsarchive.byu.edu/etd/9174.
Повний текст джерелаBlum, Michael G. B. "Statistique bayésienne et applications en génétique des populations." Habilitation à diriger des recherches, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00766196.
Повний текст джерелаVanee, Niti. "HIGH THROUGHPUT DATA FRAMEWORK BASED CHARACTERIZATION AND EVALUATIONS OF THERMOBIFIDA FUSCA FOR INDUSTRIAL APPLICATIONS." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3274.
Повний текст джерелаRamraj, Varun. "Exploiting whole-PDB analysis in novel bioinformatics applications." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:6c59c813-2a4c-440c-940b-d334c02dd075.
Повний текст джерелаEL, Berbari Racha. "Segmentation d'images de contraction et de rehaussement tardif en IRM cardiaque. Application a l'étude de la fonction contractile et de la viabilité myocardique." Phd thesis, Télécom ParisTech, 2009. http://pastel.archives-ouvertes.fr/pastel-00006081.
Повний текст джерелаReinert, Tilo [Verfasser], Tilman [Akademischer Betreuer] Butz, Josef [Gutachter] Käs, Philippe [Gutachter] Moretto, and Günter [Gutachter] Schmahl. "Focussed MeV-Ion Micro- and Nano-Beams in the Life Sciences : Selected Applications / Tilo Reinert ; Gutachter: Josef Käs, Philippe Moretto, Günter Schmahl ; Betreuer: Tilman Butz." Leipzig : Universitätsbibliothek Leipzig, 2016. http://d-nb.info/1240396120/34.
Повний текст джерела