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1
Yeoh, Francis. "Choreographers and copyright ownership: investigating an apparent dysfunction." Journal of Intellectual Property Law & Practice 10, no. 12 (November 24, 2015): 911–20. http://dx.doi.org/10.1093/jiplp/jpv172.
Повний текст джерела
2
Saunders, Peter. "Privatization, Share Ownership and Voting." British Journal of Political Science 25, no. 1 (January 1995): 131–37. http://dx.doi.org/10.1017/s0007123400007092.
Повний текст джерелаАнотація:
Popular support for the British government's privatization programme has never exceeded 40 per cent of the electorate, and by the end of the 1980s, huge public flotations of industries like water and the electricity suppliers and generators were taking place in the teeth of widespread popular opposition. The evidence on voting behaviour suggests, however, that it was the Labour party rather than the Conservatives which lost electoral support as a result of the privatization programme. This Research Note offers an explanation for this apparent paradox.
3
Dovie, Delali A. "Assessment of How House Ownership Shapes Health Outcomes in Urban Ghana." Societies 9, no. 2 (May 30, 2019): 43. http://dx.doi.org/10.3390/soc9020043.
Повний текст джерелаАнотація:
Background: This study investigates home ownership and its apparent health outcomes in Urban Ghana, utilizing both quantitative and qualitative datasets. Methods: The sample for the study consisted of 442 respondents using a multi-stage sampling technique. Results: The context in which houses are situated affects social support networks, physical and mental health outcomes. House ownership is then a precondition that enables social contact within neighborhoods. A Cramer’s V test value of 0.750 suggests a strong association between house ownership and health outcomes. Conclusion: House acquisition and ownership can potentially improve overall physical, and mental health and wellbeing.
4
Anderson, B. L. "Border Ownership as a Special Case of Contrast Ownership." Perception 25, no. 1_suppl (August 1996): 1. http://dx.doi.org/10.1068/v96l1212.
Повний текст джерелаАнотація:
The classification of boundaries as figure and ground is one of the fundamental computations performed by the visual system. This computation requires classifying one side of a boundary, as an occluding or ‘intrinsic’ contour, and the other side of the contour as occluded or ‘extrinsic’ (also described as the problem of border ownership). A recent analysis of stereoscopic contour junctions revealed that the classification of edges as intrinsic or extrinsic to a neighbouring surface depends critically on the relative depth of the contours at the image junction. Specifically, it was argued that near edges are intrinsically one-sided (ie border ownership is uniquely specified by the junction geometry), whereas far contours are inherently two-sided (ie the border ownership of the far contour cannot be determined on the basis of the local junction geometry). Here I present new stimuli that reveal that the asymmetry of near and far contours in specifying border ownership reflects a more general asymmetry in the classification of near and far contrasts. A variety of stimuli were created. In one set of patterns, an array of five circular discs was embedded on a homogeneous background (either white or black) and was filled with a texture. A uniform disparity was added to the textured region such that it appeared nearer than the outer edges of the disc. When the power spectrum of the texture was systematically varied as functions of 1/ fn, the texture did not appear as a solid surface. Rather, the discs containing the texture gradients were decomposed into two sources: a constant background colour of the discs, and transparent clouds that appeared to float in front of the discs. Remarkably, the apparent colour of the clouds and the discs could be transformed simply by changing the colour of the background of the regions that neighboured the discs; the texture itself was unchanged. Specifically, when the textured discs were placed on white backgrounds, the pattern appeared as white clouds hovering in front of dark discs; but when the textured discs were placed on black backgrounds, the percept was of black ‘smoke’ hovering in front of white discs. It is argued that these results reveal that the problem of border ownership is a special case of contrast ownership. The two-sided qualities of far contrasts determine the colour of the background, which in turn determines which side of a near gradient is considered to be more or less opaque (ie which side is more occlusive).
5
Schrire, Carmel. "What Can Archaeology Say about Capitalism?" Archaeological Dialogues 8, no. 1 (September 2001): 34–35. http://dx.doi.org/10.1017/s1380203800001847.
Повний текст джерелаАнотація:
The apparent aim of this paper is to reveal the contribution of archaeology to understanding the social relations of capitalism. The burden of this particular study of rural settlement in the Scottish Highlands is to show that archaeology helps to achieve a deeper understanding of the transition from clan ownership to individual ownership during the period of Improvement that heralded the dawn of the new commercial age in the eighteenth and nineteenth centuries.
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Cates, Christopher R. "Legal Issues within the Intellectual Property Policies of Canadian Universities." Industry and Higher Education 16, no. 6 (December 2002): 355–67. http://dx.doi.org/10.5367/000000002101296522.
Повний текст джерелаАнотація:
Several Canadian universities use their internal policies to claim some form of ownership or licence right with respect to student-created intellectual property. These policies are examined from a contract and employment law viewpoint to determine their efficacy It is concluded that a university would have significant legal issues to overcome before successfully claiming ownership of intellectual property created by its students. Specific recommendations are presented that attempt to resolve these apparent difficulties.
7
Lamb, Robert. "For and Against Ownership: William Godwin's Theory of Property." Review of Politics 71, no. 2 (2009): 275–302. http://dx.doi.org/10.1017/s0034670509000345.
Повний текст джерелаАнотація:
AbstractThis article offers an interpretation of British philosopher William Godwin's theory of property ownership, as outlined in hisEnquiry Concerning Political Justice. Godwin's work can be read as presenting an incoherent account of property rights, which, on the one hand, justifies its existence on seemingly utilitarian grounds while, on the other, impugns its legitimacy on egalitarian grounds. But the contradiction apparent in Godwin's position is actually illusory and can in fact be plausibly interpreted as comprising a coherent two-level understanding of political morality, wherein the right to own private property is best comprehended as a “right to do wrong.”
8
Choi, Paul Moon Sub, Joung Hwa Choi, Chune Young Chung, and Yun Joo An. "Corporate Governance and Capital Structure: Evidence from Sustainable Institutional Ownership." Sustainability 12, no. 10 (May 20, 2020): 4190. http://dx.doi.org/10.3390/su12104190.
Повний текст джерелаАнотація:
Because corporate sustainability enhances corporate governance principles, firms are increasing their efforts to provide transparency and public disclosure. These efforts inform the public about the relationship between corporate governance and sustainability. Well-informed shareholders know about this relationship, which is becoming more apparent over time. In this study, we empirically examined the possible bilateral relationships between institutional ownership and a firm’s capital structure. Methodologically, we used an instrumental variable approach and the two-step generalized method of moments. The implications of this study are two-fold. First, we found that a firm’s debt level was low if its institutional ownership level was high. Institutional monitoring may substitute for external debt monitoring, leading firms to employ low leverage. Second, we found that the level of institutional ownership was high if a firm’s debt level was high. This association suggests that institutional investors prefer high-leveraged firms because institutional owners decrease their monitoring costs through debt monitoring. In the long run, sustainable institutional ownership materially impacts the capital structures of firms.
9
Tan, Zhi-Xuan, Jake Brawer, and Brian Scassellati. "That’s Mine! Learning Ownership Relations and Norms for Robots." Proceedings of the AAAI Conference on Artificial Intelligence 33 (July 17, 2019): 8058–65. http://dx.doi.org/10.1609/aaai.v33i01.33018058.
Повний текст джерелаАнотація:
The ability for autonomous agents to learn and conform to human norms is crucial for their safety and effectiveness in social environments. While recent work has led to frameworks for the representation and inference of simple social rules, research into norm learning remains at an exploratory stage. Here, we present a robotic system capable of representing, learning, and inferring ownership relations and norms. Ownership is represented as a graph of probabilistic relations between objects and their owners, along with a database of predicate-based norms that constrain the actions permissible on owned objects. To learn these norms and relations, our system integrates (i) a novel incremental norm learning algorithm capable of both one-shot learning and induction from specific examples, (ii) Bayesian inference of ownership relations in response to apparent rule violations, and (iii) perceptbased prediction of an object’s likely owners. Through a series of simulated and real-world experiments, we demonstrate the competence and flexibility of the system in performing object manipulation tasks that require a variety of norms to be followed, laying the groundwork for future research into the acquisition and application of social norms.
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Barnsley, D. G. "Co-Owners' Rights to Occupy Trust Land." Cambridge Law Journal 57, no. 1 (March 1998): 123–45. http://dx.doi.org/10.1017/s0008197300134415.
Повний текст джерелаАнотація:
Few lawyers would dissent from the view, voiced by the Law Commission in 1989 in their Report on Trusts of Land, that the trust for sale mechanism, introduced in 1926 to regulate the co-ownership of land, had for long ceased to be appropriate to the conditions of modern home ownership. Every conveyancing practitioner will have experienced the difficulty of explaining to clients about to marry that the matrimonial home which they were so eagerly looking forward to occupying would by law be owned by them as trustees, subject to an immediate binding trust for sale. No doubt in practice discretion played the better part of valour. Soon after qualifying, solicitors learned to abandon any attempt to explore the mysteries of such an apparent absurdity.
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MACKINTOSH, ALAN. "Authority and ownership: the growth and wilting of medicine patenting in Georgian England." British Journal for the History of Science 49, no. 4 (November 24, 2016): 541–59. http://dx.doi.org/10.1017/s0007087416001114.
Повний текст джерелаАнотація:
AbstractSecret, owned, Georgian medicines were normally known as patent medicines, though few had a current patent. Up to 1830, just 117 medicines had been patented, whilst over 1,300 were listed for taxation as ‘patent medicines’. What were the benefits of patenting? Did medicine patenting affect consumer perception, and how was this used as a marketing tool? What were the boundaries of medical patenting? Patents for therapeutic preparations provided an apparent government guarantee on the source and composition of widely available products, while the patenting of medical devices seems to have been used to grant a temporary monopoly for the inventor's benefit.
12
Duarte, Bruno Elmôr, and Ricardo Pereira Câmara Leal. "Principal-principal conflicts leading to activism of a large government-owned investor in Brazil." Corporate Governance and Organizational Behavior Review 5, no. 1 (2021): 15–21. http://dx.doi.org/10.22495/cgobrv5i1p2.
Повний текст джерелаАнотація:
This article analyzes conflicts between principals that led to activism by one large Brazilian government-owned investor as a minority shareholder and verifies the antecedents, means employed, apparent motivations, and effectiveness of its reactions (Goranova & Ryan, 2014). It examines the cases of three large high ownership concentration listed companies using solely public sources. Poor performance was a frequent conflict antecedent. No evident trade-off between activism and corporate governance (CG) practices emerged. High ownership concentration influenced the way the investor reacted and its success because opposition through internal CG mechanisms was usually not successful and led to legal proceedings. The limitations of the regulatory framework became evident from the mixed outcomes of these proceedings. The investor was not exclusively financially motivated and it occasionally opposed the interests of other minority shareholders to follow government policy. These findings illustrated how high ownership concentration rendered difficult the mitigation of principal-principal conflicts even for a large government-owned investor and help explain the failure of previous econometric studies to relate activism, quality of CG practices and performance (Young, Peng, Ahlstrom, Bruton, & Jiang, 2008)
13
Yang, Di, Chenfeng Xiong, Arefeh Nasri, and Lei Zhang. "Hidden Markov Approach to Dynamically Modeling Car Ownership Behavior." Transportation Research Record: Journal of the Transportation Research Board 2645, no. 1 (January 2017): 123–30. http://dx.doi.org/10.3141/2645-14.
Повний текст джерелаАнотація:
It has become apparent to researchers in various domains that choice behavior occurs in a dynamic context and decision making involves strong temporal dependency, especially when it comes to car ownership decisions, because of consumers’ forward-looking behavior. However, a substantial portion of the literature focuses on static model formulations, and limitations exist, particularly in long-term travel demand forecasting. This study proposed a hidden Markov modeling (HMM) framework to analyze car ownership behavior dynamically. The dynamic model framework was applied to the 10-wave Puget Sound (Washington) Transportation Panel data. Two hidden states were identified in this study: State 1 tended to be land use entropy sensitive and vice versa for State 2. Empirical results reveal that households with preschool-age children are more likely to live in urbanized areas where they have easy access to various facilities. Also, one more licensed driver would lead to a 13.33% increase in owning two cars for State 1 households and a 28.45% increase in owning three or more cars for State 2 households. The comparison with both the multinomial logit model and the latent class model favors the study’s dynamic model framework with respect to model performance. The HMM approach offers insights on policy development for a target population and provides more accurate forecasting for long-term planning and policy analysis.
14
Jahnke, Patrick. "Ownership concentration and institutional investors’ governance through voice and exit." Business and Politics 21, no. 3 (May 8, 2019): 327–50. http://dx.doi.org/10.1017/bap.2019.2.
Повний текст джерелаАнотація:
AbstractDrawing on data collected in interviews with investors and corporates in the United States and Europe, this paper sheds light on the motives behind shareholder engagement. It explains why index funds engage in corporate governance, despite their apparent lack of financial incentive to do so. Applying Hirschman's concepts of exit and loyalty to the investment management industry, this paper suggests that for many institutional shareholders today, voice is more feasible than exit. For the largest index investors, the cost of engagement has fallen to a level where it is today negligible. The immense concentration amongst index funds, with the three largest fund managers controlling over 90 percent of assets, ensures sufficient return on their governance investments. Furthermore, interviews with activist investors suggest that they have learned to work with index investors and that index funds do not present barriers to successful campaigns. This paper therefore advocates against restricting index funds’ voting rights. Doing so would muzzle those shareholders with the deepest pockets and the greatest potential for corporate oversight. Instead what is needed is regulation to ensure greater disclosure of engagement efforts by the largest fund companies enabling greater academic and public oversight of asset managers’ engagement activities.
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Oliver-Hall, Holly, Elena Ratschen, Christopher R. Tench, Helen Brooks, Cris S. Constantinescu, and Laura Edwards. "Pet Ownership and Multiple Sclerosis during COVID-19." International Journal of Environmental Research and Public Health 18, no. 23 (December 1, 2021): 12683. http://dx.doi.org/10.3390/ijerph182312683.
Повний текст джерелаАнотація:
Background: Multiple sclerosis (MS) is associated with lower quality of life, reduced social participation, and decreased self-efficacy. The COVID-19 pandemic has had documented effects on the health and wellbeing of people with and without MS. Previous research has demonstrated the positive impact pets can have for people living with long-term conditions. Objectives: To explore the rates of pet ownership and pet attachment in people living with MS and pet ownership associations with quality of life, satisfaction with social roles, and self-efficacy scores; and to explore the effects of the COVID-19 outbreak on people’s perceived relationships with their pets. Materials and Methods: A postal questionnaire was distributed to members of a local MS Register and a control group of people without MS. The questionnaire assessed quality of life, satisfaction with social roles, self-efficacy, the perceived roles of pets, and pet-related concerns experienced during the COVID-19 pandemic. Results: No apparent difference in attachment to pets was found between the patient and control groups. Pet ownership and level of attachment were not associated with differences in quality of life or self-efficacy scores in people living with MS. Using multiple regression analysis, pet ownership was associated with a decrease in satisfaction with participation in social roles, but with the estimated effect being small compared to having a diagnosis of MS or being unemployed. Most participants reported that pets had positive roles during the pandemic, and the most reported pet-related concern was access to veterinary treatment. Conclusion: Pet owners both with and without MS reported subjective benefits to their wellbeing from pet ownership during COVID-19, although analysis suggested that pet ownership was associated with a reduction in satisfaction with social roles. The study had several limitations and suggestions are made for future work.
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Small, Garrick R. "Property, Commerce, and Living God's Will." Journal of Interdisciplinary Studies 16, no. 1 (2004): 157–72. http://dx.doi.org/10.5840/jis2004161/29.
Повний текст джерелаАнотація:
Market capitalism requires absolute private property, and both institutions appeared at about the same time in history. The morality of the market rests on the morality of property, which may be argued both from Scripture and secular perspectives. Both approaches yield a theory of property that supports private ownership conditional on obligations to the community. Apparent contradictions in Scripture regarding property are resolved by this approach. Property ownership confers economic power on its holder. Modernity assumes that this power must be controlled by external forces-either by the market, or the state-but both limit freedom. True moral action must be free. The moral opportunity of the market is to avoid using economic power to exploit others, especially the weak and needy. Christian thought supplies the outline principles for moral guidance for ethical market action that revolve about self-restraint.
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Munugalavadla, Veerendra, Leanne Berry, Yung-Hsiang Chen, Gauri Deshmukh, Jake Drummond, Changchun Du, Michael Eby, et al. "A Selective PIM Kinase Inhibitor Is Highly Active In Multiple Myeloma: Mechanism of Action and Signal Transduction Studies." Blood 116, no. 21 (November 19, 2010): 4084. http://dx.doi.org/10.1182/blood.v116.21.4084.4084.
Повний текст джерелаАнотація:
Abstract Abstract 4084 Related work from our group has shown the therapeutic utility of PIM inhibition in multiple myeloma cell lines, xenografts, and primary patient samples (Ebens A. et al., ASH 2010 submitted abstr.). In this study we provide detailed mechanistic findings to show that PIM kinase inhibition co-regulates several important elements of the PI3K/AKT/mTOR pathway, resulting in significant synergy for combination drug treatments. The PIM kinases are a family of 3 ser/thr growth factor- & cytokine-induced proteins hypothesized to have redundant survival and growth functions. GNE-652 is a pan-PIM kinase inhibitor with picomolar biochemical potencies and an excellent kinase selectivity profile. Myeloma cell lines exhibit sensitivity to single agent PIM inhibition and a striking synergy in combination with the PI3K inhibitor GDC-0941. Cells respond to this combination with cell cycle arrest and marked apoptosis in vitro. We tested a panel of selective PI3K/AKT/mTOR inhibitors and found PI3K and AKT inhibitors showed the greatest extent of synergy with GNE-652, whereas mTOR inhibitors were synergistic to a lesser extent. These results suggest that PIM signaling converges on both TORC1 and AKT to generate these differential synergies. BAD is a negative regulator of both Bcl-2 and Bcl-XL, and we were able to confirm previous reports that AKT and PIM cooperate to inactivate BAD (Datt et al., 1997; Yan et al., 2003). Pim has been shown to potentially inactivate PRAS40, a negative regulator of TORC1 (Zhang et al., 2009). We demonstrate that PIM or PI3K inhibition caused a loss of phosphorylation on PRAS40 and results in a physical association of PRAS40 and TORC1 and a decrease in phosphorylated p70S6K and S6RP. These reductions were apparent in 7 of 7 cell lines assayed and enhanced by the combination of PI3K and PIM inhibition in these cell lines. Consistent with prior reports (Hammerman et al., 2005), we show that a second node of convergence between PIM and TORC1 is 4E-BP1. Both GDC-0941 and GNE-652 treatments reduced phosphorylation of 4E-BP1 in 7 of 7 myeloma cell lines. Since dephosphorylated 4E-BP1 competes with eIF4G for the mRNA cap binding factor eIF4E, we assayed immunoprecipitates of eIF4E for the presence of eIF4G and 4E-BP1 and observed increased BP1 and decreased 4G. The combination treatment significantly enhanced the loss of 4G relative to either single agent, and importantly, even at 5× the IC50 concentrations for single agents, combination drug treatment achieved greater extent of effect than single agent treatment. Thus PI3K and PIM pathways are redundant at the level of cap-dependent translational initiation mediated by eIF4E. It has been hypothesized a subset of mRNAs are particularly sensitive to inhibition of cap-dependent translation, and that this includes a number of oncogenes such as cyclin D1. We assayed global protein synthesis in MM1.s cells using 35S-methionine and as expected we observed only a modest ≂∼f20% decrease caused by either GNE-652 or GDC-0941 and this decrease was not enhanced by combination treatment. However, we noted across 7 different myeloma cell lines, strong decreases in levels of cyclin D1 that were enhanced by combination treatment. In summary, we have identified several points at which PIM and PI3K/AKT/mTOR converge to provide synergistic apoptosis in multiple myeloma cell lines. These results provide the rationale for further preclinical development of PIM inhibitors and provide the basis for a possible clinical development plan in multiple myeloma. Disclosures: Munugalavadla: Genentech: Employment, Equity Ownership. Berry:Genentech: Employment, Equity Ownership. Chen:Genentech: Employment, Equity Ownership. Deshmukh:Genentech: Employment, Equity Ownership. Drummond:Genentech: Employment, Equity Ownership. Du:Genentech: Employment, Equity Ownership. Eby:Genentech: Employment, Equity Ownership. Fitzgerald:Genentech: Employment, Equity Ownership. S.Friedman:Genentech: Employment, Equity Ownership. E.Gould:Genentech: Employment, Equity Ownership. Kenny:Genentech: Employment, Equity Ownership. Maecker:Genentech: Employment, Equity Ownership. Moffat:Genentech: Employment, Equity Ownership. Moskalenko:Genentech: Employment, Equity Ownership. Pacheco:Genentech: Employment, Equity Ownership. Saadat:Genentech: Employment, Equity Ownership. Slaga:Genentech: Employment, Equity Ownership. Sun:Genentech: Employment, Equity Ownership. Wang:Genentech: Employment, Equity Ownership. Yang:Genentech: Employment, Equity Ownership. Ebens:Genentech Inc: Employment, Equity Ownership.
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Buck, Glenn H., Edward A. Polloway, Amy Smith-Thomas, and Kelly Wilcox Cook. "Prereferral Intervention Processes: A Survey of State Practices." Exceptional Children 69, no. 3 (April 2003): 349–60. http://dx.doi.org/10.1177/001440290306900306.
Повний текст джерелаАнотація:
Without a federal mandate providing clear guidelines for specific practices, prereferral intervention practices are implemented in varied ways within and between the states. The current study focused on practices across all states as a replication of the research reported in 1989 by Carter and Sugai. Significant findings included the status of prereferral practices within the respective states, the pattern of terminology used, the professional ownership of the process, and the patterns of participation. The results are discussed in terms of changes noted since the Carter and Sugai research, apparent trends in the field, and directions for effective professional practice.
19
Tsang, Eric W. K. "In Search of Legitimacy: The Private Entrepreneur in China." Entrepreneurship Theory and Practice 21, no. 1 (October 1996): 21–30. http://dx.doi.org/10.1177/104225879602100102.
Повний текст джерелаАнотація:
Private business is booming in China and the entrepreneurial spirit sweeps through the country. However, the apparent contradiction between Marxist ideology and private ownership has not been satisfactorily resolved. The ideological problems of labor exploitation and income polarization associated with private business have serious repercussions on policy implementation and have constrained the entrepreneurial development. Operating in a hostile institutional environment, many private entrepreneurs in China demonstrate some peculiar behavior seldom found In other countries. By using the concept of legitimacy, it is argued here that the entrepreneurs behavior is the result of their strategic responses to their less-than-legitimate status.
20
Cherlet, Jan, and Jean-Philippe Venot. "Structure and agency: understanding water policy changes in West Africa." Water Policy 15, no. 3 (February 14, 2013): 479–95. http://dx.doi.org/10.2166/wp.2013.086.
Повний текст джерелаАнотація:
Ownership of development processes has been high on the international agenda since the Paris Declaration of 2005. There is, however, much discussion about whether highly aid-dependent governments can really ‘own’ policy reforms in their countries. In this paper, we argue that the ownership of policy reforms is the outcome of an interaction between individual agency and structural conditions. Taking the implementation of Integrated Water Resources Management (IWRM) in Burkina Faso (since 1996) and Mali (since 2004) as an entry point, the paper describes the interplay between national policy makers, international organizations and dominant development discourses in the shaping of water policy reforms in both countries over the past 15 years. Despite the apparent uniformity of the global IWRM paradigm, a qualitative comparison of water policy changes in the two countries shows that policy reforms, as well as the extent to which they are ‘owned’ by national policy makers, are significantly distinct. This can be explained by different forms of individual agency and diverse structural conditions at a national level.
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Le, Kha, Russ Wada, David Dai, Bin Fan, Guowen Liu, Hua Liu, Eyal C. Attar, Samuel V. Agresta, and Hua Yang. "Population Pharmacokinetics of Ivosidenib (AG-120) in Patients with IDH1-Mutant Advanced Hematologic Malignancies." Blood 132, Supplement 1 (November 29, 2018): 1394. http://dx.doi.org/10.1182/blood-2018-99-109863.
Повний текст джерелаАнотація:
Abstract BACKGROUND: Ivosidenib, a potent mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor, is being assessed in a phase 1 study of mIDH1 advanced hematologic malignancies (NCT02074839). We characterized the pharmacokinetics (PK) of ivosidenib in this population, and the effects of patient/disease characteristics and concomitant medications. METHODS: Ivosidenib was given in continuous 28-day cycles at 100 mg twice daily and 300 mg, 500 mg, 800 mg, and 1200 mg once daily (QD). Enrollment is complete; 258 patients received ≥1 ivosidenib dose (78 in escalation, 180 in expansion); samples were available from 253 patients (223 received ivosidenib 500 mg QD). Ivosidenib concentrations were determined using validated liquid chromatography with tandem mass spectrometry (LC-MS/MS)-based methods. Population PK modeling was conducted using NONMEM software. The impact of demographics, renal and hepatic function, disease type, Eastern Cooperative Oncology Group (ECOG) performance status, and concomitant cytochrome P450 3A4 (CYP3A4) inhibitors/inducers and gastric acid reducers on ivosidenib PK was explored. RESULTS: Ivosidenib PK were best described using a 2-compartment model with first-order absorption, dose-dependent bioavailability, and a time-dependent change in relative bioavailability and clearance between Day 1 and steady state. Mean steady-state apparent clearance (CL/F) was 5.39 L/h (between-patient variability ~35%) and mean central volume of distribution (Vc/F) was 234 L (~47%). Less than dose-proportional bioavailability was observed, with a dose doubling translating to a ~40% increase in exposure. The moderate/strong CYP3A4 inhibitors voriconazole, fluconazole, and posaconazole were associated with 36%, 41%, and 35% reductions in CL/F, and hence 57%, 69%, and 53% increases in area under the plasma ivosidenib concentration-time curve (AUC), respectively (Figure 1). Baseline body weight had a significant impact on Vc/F. Low albumin at baseline and during treatment correlated with decreased CL/F and Vc/F. However, the effects of body weight and albumin did not appear to be clinically relevant. No effects of creatinine clearance or measures of liver function (alanine aminotransferase, aspartate aminotransferase, bilirubin, within the range studied) on ivosidenib CL/F were detected. Concomitant use of pantoprazole or famotidine did not affect ivosidenib CL/F. CONCLUSION: This population PK model of ivosidenib suggests that no dose adjustments are needed based on the range of patient and disease characteristics analyzed. Disclosures Le: Millennium: Patents & Royalties; Agios: Employment, Equity Ownership. Wada:Certara: Employment; Agios: Consultancy. Dai:Agios: Employment, Equity Ownership. Fan:Agios: Employment, Equity Ownership. Liu:Agios: Employment, Equity Ownership. Liu:Agios: Employment, Equity Ownership. Attar:Agios: Employment, Equity Ownership. Agresta:Agios: Employment, Equity Ownership. Yang:Agios: Employment, Equity Ownership.
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Tan, Siyuan, Joe Salas, Kai Chen, Tamera Ashworth, Sarah Smith, Elena Kistanova, Nancy Moore, et al. "Enhancing the Acute Hemostatic Efficacy in Cynomolgus Monkeys By Targeting Activated Coagulation Factor VII to Platelets." Blood 124, no. 21 (December 6, 2014): 1488. http://dx.doi.org/10.1182/blood.v124.21.1488.1488.
Повний текст джерелаАнотація:
Abstract Recombinant activated factor VII (rFVIIa) is used for controlling bleeds in hemophilia A and B patients with inhibitory antibodies against factor VIII or factor IX. The hemostatic effect of rFVIIa at pharmacological doses is believed to be mediated by activating the tenase complex on platelets directly at the site of injury to promote thrombin generation. To increase the hemostatic activity of rFVIIa, we sought to target rFVIIa to platelets by fusing a single chain variable region of a monoclonal antibody against human platelet receptor αIIbβ3. The resulting fusion protein, FVII-189, displays higher affinity to human platelets and about 50-fold higher hemostatic activity than that of rFVIIa in whole blood from hemophilia A patients by rotational thromboelastometry (ROTEM). Here we investigated the safety, pharmacokinetics, and pharmacodynamics of FVII-189 in cynomolgus monkeys. First, we confirmed that FVII-189 cross-reacted to platelets from cynomolgus monkeys. When spiked in the monkey whole blood, FVII-189 could bind platelets in a dose-dependent manner, as measured by flow cytometry using fluorescently labeled antibodies against FVII, whereas platelet-binding by rFVIIa was not detectable in the same assay. More importantly, increased hemostatic activity of FVII-189 was observed by ROTEM in acquired hemophilic monkey blood where factor VIII activity was neutralized by the inhibitory antibodies. We then evaluated FVII-189 in cynomolgus monkeys following a bolus intravenous administration (n=3) at an equal molar dose to the pharmacological dose of rFVIIa (~2 nmol/kg). rFVIIa was included as a comparator. Both FVII-189 and rFVIIa appeared to be well tolerated with no abnormal clinical observations that could be attributed to the dosing. No apparent effects on platelet count in whole blood, as well as other hematology and coagulation parameters except for a temporary decrease in prothrombin time over a few hours, which was an expected pharmacological effect of rFVIIa and FVII-189. Compared to rFVIIa, FVII-189 cleared more rapidly in plasma, and distributed more to the platelets. The half-life of FVII-189 antigen on platelets was found to be several fold longer than that of rFVIIa antigen in plasma, as measured by ELISA of the platelet-rich plasma, or by flow cytometry of platelet-associated FVII-189 antigen. Despite the lower initial recovery and faster clearance of FVII-189 in plasma, directing FVII-189 to platelets resulted in much higher hemostatic activity of the whole blood 5 minute and 1 hour after dosing, as measured by ex vivo ROTEM assay. In conclusion, these results indicate that in cynomolgus monkeys, 1) FVII-189 is safe and does not affect the platelet clearance, 2) FVII-189 protein is targeted to platelets with fast clearance in plasma and prolonged half-life on platelets and 3) FVII-189 could be more efficacious in controlling acute bleeds than rFVIIa. Disclosures Tan: Biogen Idec: Employment, Equity Ownership. Salas:Biogen Idec: Employment, Equity Ownership. Chen:Biogen Idec: Employment, Equity Ownership. Ashworth:Biogen Idec: Employment, Equity Ownership. Smith:Biogen Idec: Employment, Equity Ownership. Kistanova:Biogen Idec: Employment, Equity Ownership. Moore:Biogen Idec: Employment, Equity Ownership. Acosta:Biogen Idec: Employment, Equity Ownership. Kole:Biogen Idec: Employment, Equity Ownership. Light:Biogen Idec: Employment, Equity Ownership. Peters:Biogen Idec: Employment. Jiang:Biogen Idec: Employment, Equity Ownership.
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Whiting, Kezia. "What Bertha Knows: Proprietary Narration in Katherine Mansfield’s “Bliss”." Twentieth-Century Literature 68, no. 4 (December 1, 2022): 437–65. http://dx.doi.org/10.1215/0041462x-10237795.
Повний текст джерелаАнотація:
How do we know what a character knows? What assumptions do we make about a character and their awareness when we read a text? How, in fact, does a text codify and construct knowledge, character, and thought? This essay addresses these questions in relation to Katherine Mansfield’s short story, “Bliss.” Most readers of “Bliss” assume that the protagonist, Bertha, knows nothing of her husband’s apparent affair with a guest at their dinner party and even that she is unaware of her own burgeoning homosexual desire for this same guest. And yet the persistent ambiguity of Mansfield’s free indirect style, at the least, allows Bertha to be read as knowing, deliberate, and complicit in her apparent ignorance. In conjunction with the text’s critique of gender roles and expectations, Mansfield’s free indirect style implicitly criticizes her reader’s willingness to sideline Bertha’s self-awareness. Mansfield’s demonstration of the fungibility of the ownership of thoughts is underscored by her critique of Bertha’s largely privileged lifestyle filled with possessions she is ultimately unable to fully possess.
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Masri, Mawar. "Towards Prevalence of Negeri Sembilan Malay Traditional Architecture for Future Communities: Misconceptions." Asian Journal of Environment-Behaviour Studies 3, no. 8 (May 23, 2018): 187–204. http://dx.doi.org/10.21834/aje-bs.v3i8.289.
Повний текст джерелаАнотація:
Negeri Sembilan’s unique identity is facing gradual disappearance endangering future generation’s identity’s ownership as well as cultural and built environment quality due to such misconception. This paper seek to present the findings of a comprehensive literature reviews which then tested by a perception survey. The literature review is part of the research activities aimed in unravelling the authenticity of Negeri Sembilan traditional houses. The research methodology was qualitative. This paper enables understanding of apparent misconception and an important milestone on an on-going research towards preserving the Negeri Sembilan architectural identity for our future communities in facing environmental challenges.
Keywords: Negeri Sembilan traditional architecture; misconception; identity ownership; future communities.
eISSN 2514-751X © 2018. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
https://doi.org/10.21834/aje-bs.v3i8.289
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Valtysson, Bjarki. "Facebook as a Digital Public Sphere: Processes of Colonization and Emancipation." tripleC: Communication, Capitalism & Critique. Open Access Journal for a Global Sustainable Information Society 10, no. 1 (January 30, 2012): 77–91. http://dx.doi.org/10.31269/triplec.v10i1.312.
Повний текст джерелаАнотація:
In this article, Facebook, as a communicative space, is treated as a public sphere in order to identify processes of colonization and emancipation. The analysis focuses on Facebook’s communicative-structural contexts, in particular from the viewpoint of user terms, user manoeuvre, privacy/data use policy, and ownership and use of uploaded material. The analysis is also based on qualitative data from Danish Facebook users, where the focus was on the users’ motivation and use, their perceptions of ownership and consumerism, as well as their views on the public/private distinction that Facebook allows for/commands for. Theoretically, the article is grounded in Jürgen Habermas’ various writings on the public sphere, as well as ‘digital adaptations’ to his theory. When looked upon from the communicative-structural contexts, processes of colonization are apparent, particularly in the various grey zones identified in Facebook’s privacy/data use policy, its state-ments of rights and responsibilities and in the fashion in which users are treated as consumers. Even though the Danish Facebook users identified with this, they still conceive of Facebook as being an emancipative communicative space, as they prioritize different features of Facebook, namely networking, practical organisation, maintaining friendships, and leisure.
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Valtysson, Bjarki. "Facebook as a Digital Public Sphere: Processes of Colonization and Emancipation." tripleC: Communication, Capitalism & Critique. Open Access Journal for a Global Sustainable Information Society 10, no. 1 (January 30, 2012): 77–91. http://dx.doi.org/10.31269/vol10iss1pp77-91.
Повний текст джерелаАнотація:
In this article, Facebook, as a communicative space, is treated as a public sphere in order to identify processes of colonization and emancipation. The analysis focuses on Facebook’s communicative-structural contexts, in particular from the viewpoint of user terms, user manoeuvre, privacy/data use policy, and ownership and use of uploaded material. The analysis is also based on qualitative data from Danish Facebook users, where the focus was on the users’ motivation and use, their perceptions of ownership and consumerism, as well as their views on the public/private distinction that Facebook allows for/commands for. Theoretically, the article is grounded in Jürgen Habermas’ various writings on the public sphere, as well as ‘digital adaptations’ to his theory. When looked upon from the communicative-structural contexts, processes of colonization are apparent, particularly in the various grey zones identified in Facebook’s privacy/data use policy, its state-ments of rights and responsibilities and in the fashion in which users are treated as consumers. Even though the Danish Facebook users identified with this, they still conceive of Facebook as being an emancipative communicative space, as they prioritize different features of Facebook, namely networking, practical organisation, maintaining friendships, and leisure.
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Sattaur, Jen. "COMMODITIES, OWNERSHIP, AND THE EUSTACE DIAMONDS: THE VALUE OF FEMININITY." Victorian Literature and Culture 38, no. 1 (February 23, 2010): 39–52. http://dx.doi.org/10.1017/s1060150309990301.
Повний текст джерелаАнотація:
In an 1867 treatise on diamonds and precious stones, Harry Emanuel writes the following: [I]n the process of cutting, flaws and imperfections are often laid bare, which go much deeper than the appearance of the rough diamond would predict; and, on the other hand, the colour, apparent in the rough stone, is sometimes found to arise from the presence of flaws or specks, which are removed in cutting, thus leaving the stone white. (70) From such a description, it is easy to see the parallel to the female condition, and particularly the female condition, as it is popularly portrayed in the mid-nineteenth century. With the emphasis on purity and hidden flaws, it is not difficult to understand why the diamond could hold such symbolic significance for the female wearer, by functioning as an indicator not only of personal wealth, but of moral worth. Trollope's The Eustace Diamonds (1871), a novel which can be said to revolve around this metaphor, is essentially a novel about worth: absolute vs. transitory worth, actual vs. symbolic worth, and especially monetary vs. moral worth. Lizzie's character, the legal issues surrounding the diamonds, and the convoluted marriage arrangements which are perpetuated by or affected by the presence of the diamonds are all, in one way or another, concerned with the different types of value – moral, symbolic, monetary, etc. – placed upon commodity objects: objects which, by their very nature, can never be permanently owned, as their value lies in their exchangeability. I will return later to a discussion of the diamonds themselves. There has been considerable recent commentary on the role of commodities – whatever their worth – and of commodity culture within Trollope's novel; such readings, however, concentrate on the purely symbolic role played by commodity objects – and primarily the diamonds – in the novel; it is worth, by contrast, examining how Trollope utilizes the discourses and associations of actual commodity objects as he deploys them within his fictional world. This paper will examine the ways in which Trollope uses four commodity objects in particular – books of poetry, hunting horses, the safe box, and finally, the Eustace diamonds themselves – and the contemporary discourses surrounding them to defend the essentially mercenary character of Lizzie as a woman shaped by the demands that a commodity-driven society places upon her.
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Tan, Siyuan, Kai-Hsin Chang, Sarah Smith, Kai Chen, Timonthy Sullivan, Qianhe Zhou, Andreas Reik, et al. "Genome Editing of the Bcl11A Erythroid Specific Enhancer in Bone Marrow Derived Hematopoietic Stem and Progenitor Cells for the Treatment of Sickle Cell Disease." Blood 126, no. 23 (December 3, 2015): 203. http://dx.doi.org/10.1182/blood.v126.23.203.203.
Повний текст джерелаАнотація:
Abstract Ablation of Bcl11A could be a viable approach for the treatment of β-hemoglobinopathies such as β-thalassemia and sickle cell disease (SCD), since patients with Bcl11A haploinsufficiency have persistently high levels of fetal hemoglobin (HbF) (up to 30%), which are associated with development of minimal to no disease symptoms. Genome editing by engineered zinc-finger nucleases that target either the exon 2 (exon ZFN) or the GATA motif of the erythroid specific enhancer (enhancer ZFN) of Bcl11A has been shown to increase HbF level in erythroid progeny from mobilized peripheral hematopoietic stem and progenitor cells (PB-CD34+ HSPCs). However, peripheral mobilization of CD34+ cells is associated with high risk and currently is not an option for SCD patients. Therefore, we investigated the efficacy of genome editing of Bcl11A in bone marrow derived CD34+ cells (BM-CD34+ HSPCs). We first established a clinically compatible large-scale process to isolate CD34+ HSPCs from human bone marrow aspirates and to transiently express the ZFN protein by mRNA electroporation. The CD34+ isolation process resulted in ~ 95% pure CD34+ cells with greater than 90% viability. Both the exon and the enhancer ZFN drove 50-60% Bcl11A gene editing, resulting in a robust elevation of HbF in the erythroid progeny. Notably, the BM-CD34+ HSPCs were found to contain a small population (10 to 25%) of CD34+CD19+ pro-B cells that were refractory to ZFN transfection under our current electroporation condition. Since CD34+CD19+ pro-B cells are not expected to contribute to reconstituting the hematopoietic system other than B-cell lineage, the Bcl11A editing efficiency in the multipotent BM-CD34+ HSPC could be even higher. The engraftment abilities of Bcl11A edited BM-CD34+ cells were then investigated in an immunodeficient NOD/scid/gamma (NSG) mouse model. At a dose of 1 million cells per mouse, treatment with either the exon ZFN or the enhancer ZFN did not detectably impact engraftment or multi-lineage reconstitution compared with untreated cells. However, Bcl11A marking in engrafted human cells was found to be markedly higher in the mice treated by the enhancer ZFN than that by the exon ZFN. The exon ZFN resulted in a strong bias towards in-frame mutations across multi-lineages with the strongest effect observed in the B-cell lineage, suggesting that a threshold level of Bcl11A is required for efficient hematopoietic reconstitution and that cells fully lacking it due to disruption of the coding sequence are at a disadvantage. In contrast, the enhancer ZFN resulted in comparable Bcl11A marking across all lineages with no apparent selection for cells with a functional GATA sequence. Collectively, these data indicate that genome editing of the erythroid specific enhancer of Bcl11A in BM-CD34+ promotes HbF reactivation in the erythroid progeny while maintaining the engraftment and multi-lineage repopulating activities of edited BM-CD34+ HSPCs, which supports further clinical development of this approach for the treatment of SCD. Disclosures Tan: Biogen: Employment, Equity Ownership. Chang:Biogen: Employment, Equity Ownership. Smith:Biogen: Employment, Equity Ownership. Chen:Biogen: Employment, Equity Ownership. Sullivan:Biogen: Employment, Equity Ownership. Zhou:Biogen: Employment, Equity Ownership. Reik:Sangamo BioSciences: Employment, Equity Ownership, Patents & Royalties: Patent applications have been filed based on this work. Urnov:Sangamo BioSciences: Employment, Equity Ownership, Patents & Royalties: Patent applications have been filed based on this work. Rebar:Sangamo BioSciences: Employment. Danos:Biogen: Employment, Equity Ownership. Jiang:Biogen: Employment, Equity Ownership.
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Lee, Ann, Sandra Kennett, Sheny Khera, and Shelley Ross. "Perceptions, practice, and “ownership:” experiences in continuity of the patient-doctor relationship in a family medicine residency." Canadian Medical Education Journal 8, no. 4 (December 16, 2017): e74-85. http://dx.doi.org/10.36834/cmej.42288.
Повний текст джерелаАнотація:
Background: The objective of this mixed-methods study was to determine interpersonal continuity (the ongoing therapeutic relationship between patient and health care provider) experiences of family medicine residents and preceptors, and explore their perceptions of interpersonal continuity.Methods: Quantitative data on resident and preceptor encounters were extracted from the electronic medical record (EMR). Opportunities for developing interpersonal continuity were determined using the Usual Provider Continuity (UPC) Index. A qualitative descriptive research method was used for the qualitative portion. Semi-structured interviews were conducted and constant comparative analysis was used to determine emerging themes.Results: Residents were found to have low UPC rates; preceptor rates were higher. Qualitative findings showed variable experiences with interpersonal continuity not apparent from UPC rates. Both preceptors and residents expressed perception of “ownership” of patients as a significant barrier to interpersonal continuity. Conclusion: This study suggests that a perceived lack of individual “ownership” of a patient panel was a significant barrier to developing interpersonal continuity. This might conflict with current changes towards team-based health care delivery. Understanding perceptions and changing them through a multi-faceted approach including resident teaching and faculty development might help improve interpersonal continuity which are core to both family medicine curricula and current models of health care delivery.
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Falter, Michelle M. "A Re-Vision of To Kill a Mockingbird and Roll of Thunder, Hear My Cry." Study and Scrutiny: Research on Young Adult Literature 1, no. 1 (May 31, 2015): 125. http://dx.doi.org/10.15763/issn.2376-5275.2015.1.1.125-155.
Повний текст джерелаАнотація:
In this paper the author argues for a “re-visioning” of two young adult literature texts by examine the ways in which race is constructed/deconstructed within <em>To Kill a Mockingbird</em> and <em>Roll of Thunder, Hear My Cry. </em>The piece begins by examining how the books are perceived in mass culture, then leads into an analysis of how race is (de)constructed through key scenes related to family, history and land ownership. By examining the two pieces of literature in tandem, differing ideologies become apparent. Implications for the teaching of these texts in light of these ideologies, the selective tradition, and authenticity in the selection of multicultural texts conclude this piece.
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Qadeer, M., Shabnam Gul, and Muhammad Faizan Asghar. "Money Laundering and Power Politics in Pakistan." Global Legal Studies Review VI, no. I (March 30, 2021): 27–34. http://dx.doi.org/10.31703/glsr.2021(vi-i).04.
Повний текст джерелаАнотація:
Tax avoidance practices are considered by the show of offenders restricting them as apparent sources and ownership. This is unlawful Mon, that is, illegal Mon. If not, Mon will lose his one-of-a-kind character. The importance of Interpol was gotten by UNO on General get together 1995. May convey a huge load of learning results. Cheats, insider trades, pay off and different fakes will impact counterfeit plan and may in like manner produce immense advantages. At the point when type exercises is redesigned, individual individuals will contain should track down the same method to sort out control these assets by will crumble assets into any little pieces, and character will be brought when personality is put into use.
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Rossi, Ann Marie, Anna Bunin, Lawrence Iben, Matthew Welsch, Tanya Berbasova, Caterina Riillo, Marco Rossi, et al. "A Novel Class of Bifunctional Immunotherapeutic That Exploit a Universal Antibody Binding Terminus (uABT) to Recruit Endogenous Antibodies to Cells Expressing CD38 Demonstrates Anti-Multiple Myeloma Activity in Vitro and Ex Vivo against Patient Tumor Cells." Blood 134, Supplement_1 (November 13, 2019): 4411. http://dx.doi.org/10.1182/blood-2019-131794.
Повний текст джерелаАнотація:
Background: Antibody recruiting molecules (ARM) are novel, immunotherapeutic bifunctional molecules composed of two active termini connected by a linker. One of the termini binds to a target molecule on a cancer cell. The other terminus, called universal antibody binding terminus (uABT), recruit all endogenous IgG antibodies independent of their antigen binding specificity. As a result, the target cell is "opsonized" by antibodies which then bring the immune effector cells to eliminate the target through various antibody-dependent destruction mechanisms. Kleo Pharmaceuticals has developed a series of CD38-ARM mlecules which target human CD38 highly expressed by multiple myeloma cells. CD38-ARM compounds are able to mediate ADCC without depleting CD38 expressing immune effector cells like existing therapeutic antibodies such as Daratumumab. Methods: Cyclized peptides containing natural and non-natural amino-acid that selectively bind to human CD38 were identified using Peptidream Flexizyme-based, cell free Peptide Discovery Translation System. These peptides were linked to uABT antibody binder via a linker to generate the final CD38-ARM molecules Binding of CD38-ARM was tested by ternary complex formation between CD38 expressing cells, CD38-ARM and labelled human IgG1. To confirm the activity of CD38-ARM, surrogate CD16a binding and signaling assays were performed using the NFAT Promega system. Antibody dependent cellular cytotoxicity (ADCC) assays using purified NK cells from multiple donors with polymorphism variants (V/V, F/F, and V/F) of CD16a were performed to confirm activity. Live cell imaging was utilized to assess the dynamics of NK-RAJI cell interactions mediated by CD38-ARM +/- IgG. We evaluated the ability of compounds to mediate complement dependent cytotoxicity (CDC). We tested the effect of CD38-ARM on human immune cell populations within PBMC and whole bone marrow (WBM) by flow cytometry. Lastly, ex vivo samples from WBM of MM patients at diagnosis or relapse were used to evaluate CD38-ARM anti-tumor activity as well as off-target effects, without the addition of external source of IgG, through multiparametric flow-cytometry (CD45, CD19, CD38, CD138, CD56, CD27, CD8, CD117). Results: The CD38-ARM were shown to have the ability to bind to CD38 with a 7nM affinity and to human IgG1 and IgG2 with affinity of 15nM and 11nM by SPR. Activity of KP compounds was observed in all assays except for CDC. In ternary assay, KP-6 had an apparent EC50 of 16nM while KP-7's EC50 was 6nM. Both KP-6 and 7 had comparable EC50s in the single digit nanamolar range in the NFAT activation assay induced by CD16a binding was confirmed using human IgG to induce, while Daratumumab had an apparent EC50 of 0.04nM. In the ADCC assay, both KP-6 & KP-7 had EC50s of 7 & 6nM respectively, while Daratumumab had an EC50 of 0.1nM. In addition, no NK cell depletion was observed when PBMC were treated with KP compounds, whereas a profound reduction in both percentages and absolute numbers in this cell subset was observed with Daratumumab treatment. Increasing dose of CD38-ARM (range 0.1uM- 25uM) were tested in ex vivo WBM samples from MM patients together with a negative control and Daratumumab. At concentrations of 10uM and 25uM, CD38-ARM induced a significant reduction of MM cells achieving results comparable to those of Daratumumab activity (p >0.05 in both cases), while sparing all other CD38+ normal cells such as NK, T lymphocytes, monocytes and granulocytes, which are always reduced in the presence of Daratumumab. Conclusions: CD38-ARMs are able to kill MM cells by ADCC without depleting CD38 expressing immune cells contrary to existing antibodies such as Daratumumab. CD38-ARMs do not activate complement, which might be involved in the infusion reaction seen with Daratumumab. Most importantly, CD38-ARMs kill multiple myeloma cells ex vivo in patient bone marrow samples as well as plasma cell leukemia in patient blood. Combined with the in vivo efficacy data presented elsewhere, this data establishes the therapeutic potential of CD38-ARM. They also represent the first demonstration of the ARM platform ability to generate therapeutic agents tailored to a specific indication, by varying target binding moiety of the molecule. Disclosures Rossi: Kleo pharmaceuticals: Employment, Equity Ownership. Bunin:Kleo pharmaceuticals: Employment, Equity Ownership. Iben:Kleo Pharmaceuticals: Employment, Equity Ownership. Welsch:Kleo pharmaceuticals: Employment, Equity Ownership. Berbasova:Kleo Pharmaceuticals: Employment, Equity Ownership. Riillo:Kleo Pharmaceuticals: Research Funding. Ohuchi:Peptidream Inc.: Employment. Alvarez:Kleo pharmaceuticals: Employment, Equity Ownership. Kawakami:Peptidream Inc.: Employment. Nagasawa:Peptidream Inc.: Employment. Spiegel:Kleo pharmaceuticals: Equity Ownership. Rastelli:Kleo pharmaceuticals: Employment, Equity Ownership.
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Stinson, Shane R., and Robert C. Ricketts. "Shifts in Ownership Composition and Changes in the Implied Cost of Equity Capital for Dividend and Non-Dividend Stocks Following JGTRRA03." Journal of the American Taxation Association 38, no. 1 (October 1, 2015): 103–24. http://dx.doi.org/10.2308/atax-51302.
Повний текст джерелаАнотація:
ABSTRACT Prior studies of the Jobs and Growth Tax Relief Reconciliation Act of 2003, which cut individual tax rates on both dividends and capital gains, unexpectedly find that non-dividend firms were more favorably affected by this legislation than dividend firms. We address this apparent inconsistency by extending prior research to account for significant shifts in institutional holdings for non-dividend stocks relative to dividend stocks following the tax change. These clientele shifts were especially concentrated among high-risk firms and provide a plausible explanation for the results reported in prior literature. Specifically, we find that significant increases in institutional ownership for high-risk firms led to larger reductions in the implied cost of equity capital compared to other firms that were more heavily favored by individuals following the reduction in shareholder tax rates.
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Lametti, David. "Rights of Private Property in the Civil Code of the Russian Federation and in the Civil Code of Quebec." Review of Central and East European Law 30, no. 1 (2005): 29–48. http://dx.doi.org/10.1163/1573035053683209.
Повний текст джерелаАнотація:
AbstractPrivate property entails a relationship between people through objects. The objects of property rights form a necessary part of the property equation, and provide an understanding of the rights and obligations allowed and required in the exploitation of any given object. This often comes through the civilian notion of destination: the idea that certain resources have a specifi c teleology or accepted way of being properly exploited or used finds expression in various legal rules. The manner in which the destination is determined may vary: it may be formal, legal or merely tacit. This basic theme is amplified in this comparative study of the basic structure of private property rights and obligations in the Civil Code of the Russian Federation and in the Civil Code of Quebec. Other themes also become equally apparent in the course of this study. First, the Russian code contains a very rough approximation of the general structure of civil law property rights: a fullest right of ownership and different lesser entitlements or dismemberments. The dismemberments, however, are quite unique to the Russian context. Second, both property rights and obligations are articulated much more explicitly and elaborately in the Russian code than in the Quebec counterpart. Third, this express enunciation of obligations and limitations on all entitlements in turn is founded on the idea that ownership is a limited concept. This foundation is in no way in contradiction to the theory of ownership in Western legal theory and practice. Finally, as a general observation, the continuing role of the state in the Russian private property system as articulated in the Russian code is much more pronounced. This is true both in its role as a legislator and enforcement agent of property limitations, as well as its express role as an actor in certain of the lesser entitlements.
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Duncan, Leah. "The Proxy Problem: Using Nonprofits to Solve Misaligned Incentives in the Proxy Voting Process." Michigan Business & Entrepreneurial Law Review, no. 9.2 (2020): 235. http://dx.doi.org/10.36639/mbelr.9.2.proxy.
Повний текст джерелаАнотація:
Proxy advisory firms and their influence on the proxy voting process have recently become the subject of great attention for the Securities and Exchange Commission (“SEC”) among other constituencies. A glance at recent proxy season recaps and reports, many of which devote space to discussing proxy advisory firm recommendations, reveal the significance of this influence on institutional voting. As Sagiv Edelman puts it, “proxy advisory firms exist at the nexus of some of the most high-profile corporate law discussions—most notably, the shareholder voting process, which has recently been the subject of much scholarly and legal debate.” The SEC has responded by announcing that it intends to reform the regulations, or lack thereof, surrounding proxy advisory firms. Recently, the SEC issued proposed amendments to Exchange Act Rule 14(a)-1 which would effectively codify their earlier interpretation of solicitation under this rule. The proposed amendment would “condition the availability of certain existing exemptions from the information and filing requirements . . . for proxy voting advice businesses upon compliance with additional disclosures and procedural requirements.” Furthermore, the amendments would clarify when a lack of disclosure of certain information in proxy voting advice compromises the accuracy of the advice and misleads within the meaning of the rule. The SEC believes that these extra requirements will “help ensure that investors who use proxy voting advice receive more accurate, transparent, and complete information on which to make their voting decisions.” Based on this proposal, it is apparent that the SEC is intent on rectifying some of the problems of transparency and conflicts of interest associated with proxy advisory firms. Given the increasing influence of proxy advisory firms, the misalignment of incentives between proxy firms and the institutional shareholders who use proxy firm services is troubling. This Note identifies inherent problems and concerns with proxy advisory firms and offers solutions to these issues with a focus on eliminating conflicts of interest. Using Henry Hansmann’s theory of ownership, this Note argues that nonprofit ownership of proxy advisory firms eliminates both information asymmetry and conflicts of interest inherent to the current ownership structure. Part I provides a brief overview of the problems and concerns associated with proxy advisory firms. Part II suggests two potential solutions: that Rule 206(4)-6 of the Investment Adviser Act of 1940 should be repealed or alternatively, that nonprofit ownership through investment company associations is a more effective way for investment management companies to comply with their fiduciary duties. Because profit incentive has created conflicts of interest that lead to proxy advice that may not always be in the best interest of investment manager clients, nonprofit ownership promotes transparency that allows parties who rely on the advice to make more independent decisions. Part III argues that nonprofit ownership is the most viable alternative to the status quo.
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Suzuki, Yasushi, and A. K. M. Kamrul Hasan. "An Analysis of Codified Corporate Governance Practices in the Banking Industry: The Case Study of Bangladesh." e-Finanse 14, no. 3 (September 1, 2018): 60–75. http://dx.doi.org/10.2478/fiqf-2018-0020.
Повний текст джерелаАнотація:
AbstractIntroducing a well-designed system of corporate governance is considered an effective tool to ensure the stability and resilience of a banking system. It was in 2006 when Bangladesh initiated its first corporate governance code (CG code). Despite trying to meet the code of enhancing the internal monitoring mechanisms and transparency in governance, it is apparent that the quality in bank credit portfolios continuously deteriorated. This paper aims to empirically analyze the impact of adopting the CG code on performance for eight years (2010–2017) of 21 major commercial banks of Bangladesh. In this case study, we suggest that the CG code may have given the Bangladeshi commercial banks an ill-incentive for the reduction of executive directors under the pressure of meeting a guideline to increase the ratio of independent directors. This incentive structure had a negative impact on bank performance during the period. Another finding is that the fundamental structure of ownership and control by sponsor directors remained unchanged during the period. This structure of maintaining the control of power by a group with its vested interest may have hindered the effectiveness of the CG code in Bangladesh. We suggest that the agenda of CG practices should go together with a policy for mitigating a potential bias under the ownership concentration because any attempt of adopting codified CG practices would be futile under the fundamental structure in Bangladesh.
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Jacobsmeier, Matthew L., and Daniel C. Lewis. "Barking Up the Wrong Tree: Why Bo Didn't Fetch Many Votes for Barack Obama in 2012." PS: Political Science & Politics 46, no. 01 (January 2013): 49–59. http://dx.doi.org/10.1017/s1049096512001369.
Повний текст джерелаАнотація:
AbstractIn “The Dog that Didn't Bark: The Role of Canines in the 2008 Campaign,” Diana Mutz (2010) argues that dog ownership made voters significantly less likely to vote for Barack Obama in the 2008 presidential election. We examine this claim further. Although President Obama has owned a dog since shortly after his 2008 election, we argue that Bo's presence most likely did little to improve his owner's chances of being reelected in 2012. Rather, the apparent significance of dog ownership uncovered by Mutz is due largely to key variables being omitted from the analysis. Using the same data, we show that Obama didn't so much have trouble with dog owners in 2008 as he had trouble with conservative, rural, Southern whites, who, for reasons we examine, are more likely than other Americans to own dogs. Accordingly, we suspect that Bo failed to boost Obama's vote tally in 2012. While we recognize the tongue-in-jowl tone of portions of Mutz's article, this tale is an important one, and is consistent with recent research linking racial attitudes to levels of support for Barack Obama. We also argue that while scholars are often wise to include control variables such as “South” in studies of political attitudes and behavior, it is important to consider the variety of politically relevant characteristics that such variables may be capturing.
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Studley, Thomas, Jon Drummond, Nathan Scott, and Keith Nesbitt. "Evaluating Digital Games for Competitive Music Composition." Organised Sound 25, no. 1 (March 4, 2020): 75–88. http://dx.doi.org/10.1017/s1355771819000487.
Повний текст джерелаАнотація:
Digital games are a fertile ground for exploring novel computer music applications. While the lineage of game-based compositional praxis long precedes the advent of digital computers, it flourishes now in a rich landscape of music-making apps, sound toys and playful installations that provide access to music creation through game-like interaction. Characterising these systems is the pervasive avoidance of a competitive game framework, reflecting an underlying assumption that notions of conflict and challenge are somewhat antithetical to musical creativity. As a result, the interplay between competitive gameplay and musical creativity is seldom explored. This article reports on a comparative user evaluation of two original games that frame interactive music composition as a human–computer competition. The games employ contrasting designs so that their juxtaposition can address the following research question: how are player perceptions of musical creativity shaped in competitive game environments? Significant differences were found in system usability, and also creativity and ownership of musical outcomes. The user study indicates that a high degree of musical control is widely preferred despite an apparent cost to general usability. It further reveals that players have diverse criteria for ‘games’ which can dramatically influence their perceptions of musical creativity, control and ownership. These findings offer new insights for the design of future game-based composition systems, and reflect more broadly on the complex relationship between musical creativity, games and competition.
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Jonker, Cornelius, and Sadulla Karjiker. "Copyright law in the MOBA genre: a comparative analysis of DOTA2 and League of Legends." Interactive Entertainment Law Review 5, no. 2 (December 30, 2022): 58–79. http://dx.doi.org/10.4337/ielr.2022.02.01.
Повний текст джерелаАнотація:
Abstract The multiplayer online battle arena (MOBA) video game genre has been plagued with copyright infringement cases. Some of the copyright challenges that face this genre stem from the fact that the progenitor to the genre, Defense of the Ancients (DotA), was a ‘mod’ created for an already-existing video game, Warcraft 3. Further, DotA was a community-based project and while there were predominantly three major ‘modders’, it is argued that many of the characters that appeared in DotA were, in themselves, copyrighted works that originated from contributors out of the playing-community, who made material contributions through forums, notice boards and the DotA Allstars website. This article delves into the copyright challenges facing the genre, with a specific focus on DotA, DOTA2 and League of Legends (LOL). An in-depth study is done on the copyright ownership of the mod, DotA, with a conclusion being drawn that the copyright ownership of characters found in DotA is of utmost importance, as most of the other elements found in MOBA games are not worth copying. As will be illustrated, copyright infringement challenges in the MOBA industry usually revolve around the copying of characters, many of whom draw inspiration from characters that appeared in the progenitor, DotA. With the focus of copyright ownership shifting to the characters found in DotA, the ownership attributed to the three modders in the Blizzard Entertainment, Inc and Valve Corporation v. Lilith Games (Shanghai) Co. Ltd. and uCool, Inc. suit will be critically evaluated. Finally, an approach is proposed for use in copyright infringement cases in the MOBA genre, specifically where the characters in contention are based on or derived from DotA characters, to try to address any potential copyright infringement claims where the alleged proprietor claiming infringement is not truly the copyright owner of the characters in question. As a practical illustration, the proposed approach will be applied to various DOTA2 and LOL characters, with a conclusion being drawn as to why there has been a lack of copyright infringement cases between Riot Games, the owner of LOL, and Valve Corporation, the owner of DOTA2, despite apparent similarities between various of their characters.
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Rhee, Catherine S., Elizabeth W. Scadden, Chea L. Phillip, Bum-Kyu Lee, Meeta Mistry, Friedrich F. Hoyer, Hiroki Kato, et al. "Functionally Distinct Subsets of Monocytes in Mouse and Human Blood." Blood 134, Supplement_1 (November 13, 2019): 438. http://dx.doi.org/10.1182/blood-2019-124054.
Повний текст джерелаАнотація:
The myeloid system has often been regarded as the 'dumb brute' side of cell-based immunity with limited specificity and variability of responses. Heterogeneity in innate immune cells is increasingly-recognized but still modest compared to other cell types and constrained by limited investigative tools. Here, we show that myeloid cells have inherent, restricted capabilities that can be defined and potentially exploited for the development of myeloid cell-based therapies. To study myeloid heterogeneity in vitro, we adapted a system for inducible clonal expansion of primary mouse granulocyte-monocyte progenitors (GMP) capable of differentiating into mature myeloid cells (Sykes et al., Cell, 2016). This system allows for the generation of large numbers of primary self-renewing GMP that can undergo progressive maturation to fully functional granulocytes or monocytes upon removal of an inducing agent (Fig. 1A). By isolating individual self-renewing GMP, clone-specific behaviors and genetic characterization can be tested and repeatedly evaluated. We isolated individual GMP that were capable of maturing into monocytes in vitro and tested whether their functional features were distinctive and reproducible on a clonal level. Functional capabilities that were quantitated include: 1. phagocytosis, 2. bacterial killing, 3. reactive oxygen species generation, 4. TNF-alpha production, 5. proliferation, and 6. cell surface marker production. Unsupervised clustering of clone-specific monocytic cells defined four different functional groups with distinctive gene expression programs (Fig. 1B). Surprisingly, this clustering is evident in chromatin accessibility at the GMP level without apparent transcriptomic alterations (Figs. 1C, D). Subgroups of monocytes injected into recipient mice, differentially trafficked to and resided in tissues such as bone marrow, spleen, and peritoneum. Furthermore, clones competent in phagocytizing E.coli (gram-negative) versus S.aureus (gram-positive) in vitro demonstrated differential functional ability to reduce peritoneal bacteria burden when adoptively transferred into animals with induced peritonitis. Molecular characterization of the functional subgroups defined novel subset-specific cell surface protein expression signatures. Antibody combinations reflecting each of these subgroups were applied to primary blood monocytes and enabled prospective isolation of endogenous cells representing each subset. Upon isolation, the mouse primary subset had specialized functional capabilities in vitro and in vivo comparable to the characteristics defined from the in vitro GMP system. Further, human monocyte populations in the blood could be isolated based on the parameters derived from our model and confirmed to have distinctive functional attributes. These data strongly suggest that diversity among monocytic subsets exists at baseline rather than monocytes transitioning between cellular states in response to particular stimuli. The subset-specific features appear to be established and epigenetically constrained by the time cells have achieved the level of GMP. By defining monocytic subsets with distinctive roles in disease settings, targeting or adoptively transferring them may be of therapeutic benefit. Disclosures Sykes: Clear Creek Bio: Equity Ownership, Other: Co-Founder. Scadden:Clear Creek Bio: Consultancy, Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Fog Pharma: Consultancy; Red Oak Medicines: Consultancy, Equity Ownership, Membership on an entity's Board of Directors or advisory committees; LifeVaultBio: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Bone Therapeutics: Consultancy; Novartis: Other: Sponsored research; Editas Medicine: Consultancy, Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Fate Therapeutics: Consultancy, Equity Ownership; Agios Pharmaceuticals: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Magenta Therapeutics: Consultancy, Equity Ownership, Membership on an entity's Board of Directors or advisory committees.
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Fatanti, Megasari Noer, Syarifatul Maulidiyah, Luhung Achmad Perguna, and Zainal Fatah. "Answering Agrarian Issues through Analysis of Employment Opportunities and Labor Shifting." Jurnal Socius: Journal of Sociology Research and Education 9, no. 2 (December 31, 2022): 98–108. http://dx.doi.org/10.24036/scs.v9i2.451.
Повний текст джерелаАнотація:
Agrarian research in Indonesia has developed with its variety of focus areas such as analysis of agrarian structure disparity, land ownership conflicts, and poverty. However, of the several research topics related to agrarian affairs, it is apparent that very few discuss how employment opportunities and types of labor shifting in the agriculture sector exist from a sociological perspective. Agrarian studies in this research have the objective to describe and analyze employment opportunities and types of labor shifting in the agriculture sector in Balearjo Village, Pagelaran Sub-District, Malang Regency. This study uses a qualitative descriptive approach with the data collection technique of participant observation and semi-structured interviews. The unit of analysis is employment opportunities and labor shifting in the agriculture sector, discussed with the Historical Materialism Theory of Karl Marx. Research results indicated that there is a variety of employment opportunities in the agriculture sector, not only limited to land ownership and land tilling. The same is true for patterns of labor shifting; the condition is not as simple as society shifting to non-agriculture sectors. Instead, shifts occur that are temporary in nature and continuous in a cycle depending on the harvest season. The existence of various employment opportunities that implicate labor shifting is certainly due to the existence of a material basis that determines a non-material basis. This is because the position of individuals in the agricultural working class will determine their consciousness and the ways they work.
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He, Huan. "Economic and legal analysis of state-owned assets management based on the global economic crisis." BCP Business & Management 18 (April 13, 2022): 206–10. http://dx.doi.org/10.54691/bcpbm.v18i.555.
Повний текст джерелаАнотація:
The traditional research on the management of state-owned assets is based on two premises: the ownership of state-owned assets by the whole people and the existence of principal-agent relationship. After in-depth analysis, it can be seen that the principal-agent relationship between citizens and the government does not exist, and the relationship between them is more in line with the elements of apparent agency or non cause management, which can be regarded as the relationship of apparent agency or non cause management. State regulation is not only to make up for market defects, but also to correct the mistakes of state regulation in the past. Economic law is the means of legalization of state regulation. Market Regulation, State Direct Investment Management and macro-guidance are the “Three ways of state regulation”, and the corresponding “Three components of economic law system”. For the use and management of state-owned assets, in addition to the managers being able to have higher ideological awareness and self-discipline, there should also be corresponding economic laws that explicitly regulate the management of state-owned assets, ensuring the use of state-owned assets is the purpose of serving the whole people. The World Financial Crisis reminds us of the urgent need to strengthen the legal system of financial supervision, including the supervision of financial innovation, credit supervision, capital liquidity supervision and supervision system.
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Deckert, Jutta, Jose F. Ponte, Jennifer A. Coccia, Leanne Lanieri, Sharon Chicklas, Yong Yi, Krystal Watkins, Rodrigo Ruiz-Soto, Angela Romanelli, and Robert J. Lutz. "Preclinical Mechanistic Studies Investigating Neutrophil and Lymphoid Cell Depletion By IMGN529, a CD37-Targeting Antibody-Drug Conjugate (ADC)." Blood 124, no. 21 (December 6, 2014): 3119. http://dx.doi.org/10.1182/blood.v124.21.3119.3119.
Повний текст джерелаАнотація:
Abstract CD37 is a surface antigen widely expressed on malignant B cells in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). In normal tissues, CD37 expression is restricted to lymphoid tissues and blood cells, with high levels of expression on B lymphocytes and low levels on non-B lymphoid and myeloid cells. IMGN529 is a CD37-targeting ADC currently in a Phase I clinical study in adult patients with relapsed or refractory NHL (NCT01534715). This ADC uniquely combines the intrinsic pro-apoptotic and immune effector activities of its anti-CD37 antibody component with the potent cytotoxic mechanism provided by targeted delivery of its maytansinoid payload, DM1. In the Phase I study, IMGN529 has demonstrated early evidence of clinical activity. A reduction in lymphocyte counts was also observed in the majority of patients after dosing, consistent with the proposed mechanism of action of a CD37-targeted therapy. However, in the initial dose-escalation phase, some patients experienced transient, early-onset neutropenia. To investigate the potential mechanisms of this transient neutropenia observed in patients, different pre-clinical models were considered and utilized to recapitulate clinical findings. In vitro studies with peripheral blood cells from normal human donors demonstrated that incubation with IMGN529 for 1 hour or 24 hours resulted in significant B-cell depletion with no apparent neutrophil depletion detected, similar to observations after rituximab treatment. In contrast, alemtuzumab treatment in vitro resulted in both B-cell and neutrophil depletion. This is consistent with the high level of CD37 expression on target B cells and the relatively low CD37 expression level on other blood cells. Analysis of cytokine release by normal human donor peripheral blood cells incubated with IMGN529 revealed increased levels of IL-8, CCL2 (MCP-1) and CCL4 (MIP-1β), but not IL-6 or TNF, to a similar extent as rituximab but less pronounced than alemtuzumab. An anti-murine CD37 antibody was identified to enable in vivo studies in a murine model and characterize CD37 expression on murine blood cells. Similar to the expression profile of CD37 in human peripheral blood cells, CD37 expression on murine peripheral blood cells was highest in B cells, with much lower expression seen on T cells and granulocytes. In vivo activity of the anti-muCD37 antibody and the corresponding ADC, with the same SMCC-DM1 linker-payload combination as IMGN529, was evaluated to discern antibody and payload-mediated events in comparison to the classic cytotoxic cyclophosphamide (CPA). Treatment of C57/B6 mice with 1-10 mg/kg of anti-muCD37 antibody or anti-muCD37 ADC resulted in a significant decrease in absolute lymphocyte counts (ALC) lasting greater than 7 days and a transient decrease in absolute neutrophil counts (ANC) lasting 1-2 days. A non-targeted control SMCC-DM1 ADC had no effect on ALC or ANC counts, suggesting the decrease is a CD37-mediated effect. In contrast, treatment with CPA resulted in an ALC decrease with similar kinetics but a more pronounced ANC decline. No impact on bone marrow lymphocyte, myeloid or erythroid precursor cell counts was observed in response to the anti-muCD37 antibody or anti-muCD37 ADC, whereas CPA treatment caused reduced cellularity with a decrease in the percentage of mature myeloid precursors and neutrophils in bone marrow. Elevated levels of CCL2 and CCL4 chemokines were detected in mouse plasma after anti-muCD37 ADC treatment, which may contribute to a redistribution of circulating neutrophils into peripheral tissues. Studies are currently underway to assess neutrophil distribution in murine tissues post anti-muCD37 ADC treatment. Current preclinical studies provide no clear evidence for direct IMGN529-mediated depletion of normal human neutrophils in the context of B-cell depletion in vitro. In vivo studies with an anti-muCD37 ADC recapitulate transient peripheral lymphopenia and neutropenia with no impact on bone marrow precursors observed, indicative of a different mechanism than classic chemotherapy-induced bone marrow myelosuppression. These preliminary results suggest a role for chemokine-mediated neutrophil redistribution following CD37 engagement, which is the subject of further studies. Disclosures Deckert: ImmunoGen, Inc.: Employment, Equity Ownership. Ponte:ImmunoGen, Inc.: Employment, Equity Ownership. Coccia:ImmunoGen, Inc.: Employment, Equity Ownership. Lanieri:ImmunoGen, Inc.: Employment, Equity Ownership. Chicklas:ImmunoGen, Inc.: Employment, Equity Ownership. Yi:ImmunoGen, Inc.: Employment, Equity Ownership. Watkins:ImmunoGen, Inc.: Employment, Equity Ownership. Ruiz-Soto:ImmunoGen, Inc.: Employment, Equity Ownership; sanofi: Employment. Romanelli:ImmunoGen, Inc.: Employment, Equity Ownership; sanofi: Employment. Lutz:ImmunoGen, Inc.: Employment, Equity Ownership.
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Manko, Barbara A. "Analyzing an Unconventional Success Story Chick-fil-A Fast Food Restaurants in the USA." Management 26, no. 1 (January 1, 2022): 118–43. http://dx.doi.org/10.2478/manment-2019-0087.
Повний текст джерелаАнотація:
Summary The U.S. fast-food chain Chick-fil-A, Inc. has prospered financially and scored multiple rankings at or near the top of its industry by using unconventional management practices, including some that appear to be drawbacks. This paper attempts what previous academic research has not: a thorough analysis of Chick-fil-A’s practices and policies, looking at how they might function as “success factors” and how the company has turned apparent disadvantages into advantages. The practices and policies include an unusual approach to franchising, a limited menu, private ownership, absence of global expansion, a distinctive focus on customer service and employee relations, and an explicitly Christian corporate culture. Chick-fil-A’s success, with a business model that does not fit the mold of other fast-food chains, makes the company a promising subject for further research by anyone wishing to study unconventional forms of differentiation for competitive advantage.
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Davies, Alistair, Conrad Zorn, Thomas Wilson, Liam Wotherspoon, Sarah Beavan, Tim Davies, and Matthew Hughes. "Infrastructure failure propagations and recovery strategies from an Alpine Fault earthquake scenario." Bulletin of the New Zealand Society for Earthquake Engineering 54, no. 2 (June 1, 2021): 82–96. http://dx.doi.org/10.5459/bnzsee.54.2.82-96.
Повний текст джерелаАнотація:
While it is well established that community members should participate in resilience planning, participation with genuine decision-making power remains rare. We detail an end-to-end disaster impact reduction modelling framework for infrastructure networks, embedded within a scenario-based participatory approach. Utilising the AF8+ earthquake scenario, we simulate hazard exposure, asset failure and recovery of interdependent critical infrastructure networks. Quantifying service levels temporally offers insights into possible interdependent network performance and community disconnection from national networks, not apparent when studying each infrastructure in isolation. Sequencing participation enables feedbacks between integrated modelling and participants’ impact assessments. Shared ownership of modelling outputs advances stakeholders’ understanding of resilience measures, allowing real-time implementation, increasing community resilience. Readily understood by central government, this format may increase support and resourcing, if nationally significant. Finally, this method tested integrated modelling and impacts assessments, identifying and enabling improvements for both.
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Power, Nina. "Forbrugerfeminisme – uddrag fra Den éndimensionale kvinde." Slagmark - Tidsskrift for idéhistorie, no. 63 (March 9, 2018): 135–44. http://dx.doi.org/10.7146/sl.v0i63.104074.
Повний текст джерелаАнотація:
Where have all the interesting women gone? If the contemporary portrayal of womankind were to be believed, contemporary female achievement would culminate in the ownership of expensive handbags, a vibrator, a job, a flat and a man. Of course, no one has to believe the TV shows, the magazines and adverts, and many don’t. But how has it come to this? Did the desires of twentieth-century women’s liberation achieve their fulfillment in the shopper’s paradise of ‘naughty’ self-pampering, playboy bunny pendants and bikini waxes? That the height of supposed female emancipation coincides so perfectly with consumerism is a miserable index of a politically desolate time. Much contemporary feminism, particularly in its American formulation, doesn’t seem too concerned about this coincidence. This excerpt from Nina Power’s One-dimensional woman is an attack on the apparent abdication of any systematic political thought on the part of today’s positive, up-beat feminists.
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Podshivalov, Tikhon. "Models of Actio Negatoria in the Law of Russia and European Countries." Russian Law Journal 7, no. 2 (May 30, 2019): 128–64. http://dx.doi.org/10.17589/2309-8678-2019-7-2-128-164.
Повний текст джерелаАнотація:
Actio negatoria is necessary in a situation wherein no one questions the ownership of an object by the owner, and the object remains in his possession, but someone exploits it without sufficient legal basis, treats it just as if he was endowed with the opportunity and the right to use someone else’s object. Despite the apparent simplicity of actio negatoria in the legislation of European countries, three models of this lawsuit have been developed, built according to the actio negatoria design that existed at different stages of the development of Roman private law – the common law model, the Roman model, and the German model. This study is based on the method of analysis of judicial practice and the method of comparative law. Based on the results of this study, we conclude that actio negatoria is not a universal method of protection. It is necessary to deviate from the principle of residual attention of the legislator to actio negatoria, residual, first of all, compared to rei vindicatio. Based on the analysis of the three models of actio negatoria that exist in the law of European countries, a new, fourth model of this lawsuit is proposed. Only an immovable object can be the subject of an actio negatoria dispute. Actio negatoria cannot be used to challenge the registered right to immovable objects. Actio negatoria can be used to protect the subjective right of property from a violation of ownership which is produced by interfering with possession and which does not result in dispossession.
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Lee, Sang-Dong. "Hungary’s Cultural Sector According to the Political Changes: Focusing on the Trends and Aspects of Hungarian Literature." Korea Association of World History and Culture 63 (June 30, 2022): 81–103. http://dx.doi.org/10.32961/jwhc.2022.06.63.81.
Повний текст джерелаАнотація:
This article aims to find the basis for claiming cultural homogeneity with Western Europe from a historical point of view. Additionally, by studying Hungarian literature, the article reveals characteristics of European culture during the transition to a post-socialist system such as political democratization, privatization and the establishment of the ownership system. The formation of civil society is also discussed. Social thoughts vividly shown in literature is a significant feature of Hungarian literature in the 20th century. For example, realism in the 19th century only exposed inequality and corruption in society but had no idea about initiating a revolution. However, in the 20th century, the direction of this revolution became apparent, and literature based on the socialism-based revolution emerged. Simultaneously, refusal and resistance to tradition were features of literature in the 20th century, and literature applying scientific analysis also appeared. However these tendencies captured the ideological viewpoint, and in terms of the form and style, it was more confusing and divisive than earlier days.
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Sander, Heldur, and Toivo Meikar. "About the history of conflicts over urban forestry in Estonian towns." Forestry Studies 73, no. 1 (December 1, 2020): 1–25. http://dx.doi.org/10.2478/fsmu-2020-0011.
Повний текст джерелаАнотація:
Abstract The article explores conflicts related to forests and parks of Estonian towns from the Middle Ages to the 1940s. A brief overview is first given of the development of urban forestry in Estonia. There are also cases where the loss of urban forests and the related problems that arose could have led to conflicts, but for certain reasons they did not emerge. The main focus of the research is on Tallinn and its nearby island of Naissaare and, to a lesser extent, on the town of Haapsalu. The cases with the probability of conflict are described on the example of Tallinn, Tartu and Pärnu. It is apparent that conflicts or preconditions for their emergence were caused by various reasons, both at the state and town level where local authorities and ownership relations played their role. But the causes of the conflicts can also be traced to the wider clash between military and political causes, economic development and the general public.
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Delgado, Ana, Silvio Funtowicz, and Dorothy Dankel. "Super-Computers, Evolution and the Fabrication of Life." International Journal of Social Ecology and Sustainable Development 3, no. 2 (April 2012): 11–24. http://dx.doi.org/10.4018/jsesd.2012040102.
Повний текст джерелаАнотація:
As biology moves into the digital realm, new ways of representing, manipulating, and appropriating life are emerging. In this paper, the authors examine systems and synthetic biology and map imaginaries of the making of life. The authors present how they have worked with scientists in three different laboratories in Europe and the U.S. by exploring those imaginaries with them. Focusing on scientific images, methods, and scientific traditions through a number of dialogic sessions, three imaginaries became apparent: living systems as networks, life as building blocks, and living systems as circuits. By working in this way, the authors could explore how scientists imagine their relations with nature (i.e., in terms of ownership) and their role as scientist. Exploring imaginaries of the making of life can open plural and broadly oriented and normative debates on nature, society, technology, and their relations. This kind of dynamic, interactive, and reflexive societal talk is, from the authors’ point of view, a central condition for possible sustainable futures.