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Готові списки джерел за темами / Apoptotic Photocytotoxicity

Добірка наукової літератури з теми "Apoptotic Photocytotoxicity"

Автор: Grafiati

Опубліковано: 6 вересня 2023

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Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Apoptotic Photocytotoxicity".

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Статті в журналах з теми "Apoptotic Photocytotoxicity"

1

Musib, Dulal, Mrityunjoy Pal, Md Kausar Raza, and Mithun Roy. "Photo-physical, theoretical and photo-cytotoxic evaluation of a new class of lanthanide(iii)–curcumin/diketone complexes for PDT application." Dalton Transactions 49, no. 31 (2020): 10786–98. http://dx.doi.org/10.1039/d0dt02082f.

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Анотація:

Improved ISC in La(iii) complex of curcumin, on activation with visible light, has resulted in high yield of ¹O₂ in HeLa/MCF-7 cells, leading to the oxidative stress which was responsible for remarkable caspase 3/7-dependent apoptotic photocytotoxicity.

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2

Panzarini, Elisa, Valentina Inguscio, and Luciana Dini. "Overview of Cell Death Mechanisms Induced by Rose Bengal Acetate-Photodynamic Therapy." International Journal of Photoenergy 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/713726.

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Photodynamic Therapy (PDT) is a non-invasive treatment for different pathologies, cancer included, using three key components: non-toxic light-activated drug (Photosensitizer, PS), visible light, and oxygen. Their interaction triggers photochemical reactions leading to Reactive Oxygen Species (ROS) generation, that mediate cytotoxicity and cell death. In the present paper, the most important findings about the synthetic dye Rose Bengal Acetate (RBAc), an emerging photosensitizer for its efficient induction of cell death, will be reported with the aim to integrate RBAc phototoxicity to novel therapeutic PDT strategies against tumour cells. After its perinuclear intracellular localization, RBAc causes multiple subcellular organelles damage, that is, mitochondria, Endoplasmic Reticulum (ER), lysosomes, and Golgi complex. Indeed, RBAc exerts long-term phototoxicity through activation of both caspase-independent and- dependent apoptotic pathways and autophagic cell death. In particular, this latter cell death type may promote cell demise when apoptotic machinery is defective. The deep knowledge of RBAc photocytotoxicity will allow to better understand its potential photomedicine application in cancer.

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3

Wu, Ricky W. K., Ellie S. M. Chu, Zheng Huang, Malini C. Olivo, David C. W. Ip, and Christine M. N. Yow. "An in vitro investigation of photodynamic efficacy of FosPegⓇ on human colon cancer cells." Journal of Innovative Optical Health Sciences 08, no. 05 (August 21, 2015): 1550027. http://dx.doi.org/10.1142/s1793545815500273.

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Photodynamic therapy (PDT) is a novel therapeutic approach for combating various cancers. PDT involves the administration of a photosensitizer which generates singlet oxygen after light activation. FosPegⓇ is the liposomal formulation of mTHPC. In this in vitro study, the photodynamic efficacy of FosPegⓇ on a human colon cancer cell line (HT29) was investigated via studying the cellular uptake of FosPegⓇ, FosPegⓇ PDT mediated photocytotoxicity and the cell death mechanism were triggered. FosPegⓇ PDT demonstrated its antitumor effect in a drug and light dose-dependent manner in HT-29 cells. Lethal dose (LD50) was achieved with 0.4 μg/mL of drug and 3 J/cm-2 of light dose. FosPegⓇ PDT triggered apoptotic cell death via activating caspase cascade and regulating cell cycle progression. In conclusion, FosPegⓇ-PDT is an effective measure to combat human colon cancer cells.

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4

Banerjee, Samya, Ila Pant, Imran Khan, Puja Prasad, Akhtar Hussain, Paturu Kondaiah, and Akhil R. Chakravarty. "Remarkable enhancement in photocytotoxicity and hydrolytic stability of curcumin on binding to an oxovanadium(iv) moiety." Dalton Transactions 44, no. 9 (2015): 4108–22. http://dx.doi.org/10.1039/c4dt02165g.

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5

Banerjee, Samya, Akanksha Dixit, Anjali A. Karande, and Akhil R. Chakravarty. "Endoplasmic reticulum targeting tumour selective photocytotoxic oxovanadium(iv) complexes having vitamin-B6 and acridinyl moieties." Dalton Transactions 45, no. 2 (2016): 783–96. http://dx.doi.org/10.1039/c5dt03412d.

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Анотація:

Vitamin-B6 Schiff base complexes of oxovanadium(iv) having (acridinyl)dipyridophenazine show tumor selective visible light-induced photocytotoxicity by endoplasmic reticulum targeting¹O₂-mediated apoptosis.

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6

Mukherjee, Nandini, Santosh Podder, Koushambi Mitra, Shamik Majumdar, Dipankar Nandi, and Akhil R. Chakravarty. "Targeted photodynamic therapy in visible light using BODIPY-appended copper(ii) complexes of a vitamin B6Schiff base." Dalton Transactions 47, no. 3 (2018): 823–35. http://dx.doi.org/10.1039/c7dt03976j.

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7

Lin, Hong-Jhih, Jinn-Hsuan Ho, Li-Chen Tsai, Fang-Yu Yang, Ling-Ling Yang, Cheng-Deng Kuo, Lih-Geeng Chen, Yi-Wen Liu, and Jin-Yi Wu. "Synthesis and In Vitro Photocytotoxicity of 9-/13-Lipophilic Substituted Berberine Derivatives as Potential Anticancer Agents." Molecules 25, no. 3 (February 5, 2020): 677. http://dx.doi.org/10.3390/molecules25030677.

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The objective of this study was to synthesize the 9-/13-position substituted berberine derivatives and evaluate their cytotoxic and photocytotoxic effects against three human cancer cell lines. Among all the synthesized compounds, 9-O-dodecyl- (5e), 13-dodecyl- (6e), and 13-O-dodecyl-berberine (7e) exhibited stronger growth inhibition against three human cancer cell lines, (HepG2, HT-29 and BFTC905), in comparison with structurally related berberine (1). These three compounds also showed the photocytotoxicity in human cancer cells in a concentration-dependent and light dose-dependent manner. Through flow cytometry analysis, we found out a lipophilic group at the 9-/13-position of berberine may have facilitated its penetration into test cells and hence enhanced its photocytotoxicity on the human liver cancer cell HepG2. Further, in cell cycle analysis, 5e, 6e, and 7e induced HepG2 cells to arrest at the S phase and caused apoptosis upon irradiation. In addition, photodynamic treatment of berberine derivatives 5e, 6e, and 7e again showed a significant photocytotoxic effects on HepG2 cells, induced remarkable cell apoptosis, greatly increased intracellular ROS level, and the loss of mitochondrial membrane potential. These results over and again confirmed that berberine derivatives 5e, 6e, and 7e greatly enhanced photocytotoxicity. Taken together, the test data led us to conclude that berberine derivatives with a dodecyl group at the 9-/13-position could be great candidates for the anti-liver cancer medicines developments.

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8

Wu Klingler, Wenyu, Nadine Giger, Lukas Schneider, Vipin Babu, Christiane König, Patrick Spielmann, Roland H. Wenger, Stefano Ferrari, and Bernhard Spingler. "Low-Dose Near-Infrared Light-Activated Mitochondria-Targeting Photosensitizers for PDT Cancer Therapy." International Journal of Molecular Sciences 23, no. 17 (August 23, 2022): 9525. http://dx.doi.org/10.3390/ijms23179525.

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Phthalocyanines (Pcs) are promising candidates for photodynamic therapy (PDT) due to their absorption in the phototherapeutic window. However, the highly aromatic Pc core leads to undesired aggregation and decreased reactive oxygen species (ROS) production. Therefore, short PEG chain functionalized A3B type asymmetric Pc photosensitizers (PSs) were designed in order to decrease aggregation and increase the aqueous solubility. Here we report the synthesis, characterization, optical properties, cellular localization, and cytotoxicity of three novel Pc-based agents (LC31, MLC31, and DMLC31Pt). The stepwise functionalization of the peripheral moieties has a strong effect on the distribution coefficient (logP), cellular uptake, and localization, as well as photocytotoxicity. Additional experiments have revealed that the presence of the malonic ester moiety in the reported agent series is indispensable in order to induce photocytotoxicity. The best-performing agent, MLC31, showed mitochondrial targeting and an impressive phototoxic index (p.i.) of 748 in the cisplatin-resistant A2780/CP70 cell line, after a low-dose irradiation of 6.95 J/cm2. This is the result of a high photocytotoxicity (IC50 = 157 nM) upon irradiation with near-infrared (NIR) light, and virtually no toxicity in the dark (IC50 = 117 μM). Photocytotoxicity was subsequently determined under hypoxic conditions. Additionally, a preliminarily pathway investigation of the mitochondrial membrane potential (MMP) disruption and induction of apoptosis by MLC31 was carried out. Our results underline how agent design involving both hydrophilic and lipophilic peripheral groups may serve as an effective way to improve the PDT efficiency of highly aromatic PSs for NIR light-mediated cancer therapy.

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9

Banaspati, Atrayee, Vanitha Ramu, Md Kausar Raza, and Tridib K. Goswami. "Copper(ii) curcumin complexes for endoplasmic reticulum targeted photocytotoxicity." RSC Advances 12, no. 47 (2022): 30722–33. http://dx.doi.org/10.1039/d2ra04813b.

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10

Yow, Christine M. N., N. K. Mak, Albert W. N. Leung, and Zheng Huang. "Induction of early apoptosis in human nasopharyngeal carcinoma cells by mTHPC-mediated photocytotoxicity." Photodiagnosis and Photodynamic Therapy 6, no. 2 (June 2009): 122–27. http://dx.doi.org/10.1016/j.pdpdt.2009.06.003.

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