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Дисертації з теми "ApoE-"

Автор: Grafiati
Опубліковано: 4 червня 2021
Оновлено: 25 липня 2025

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1

Dinkel, Regina Elke. "In-vivo Metabolismus der VLDL-Apolipoproteine ApoB, ApoCIII und ApoE." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-3562.

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2

Reverté, Soler Ingrid. "Neurobehavioural effects associated with postnatal exposure to decabromodiphenyl ether in apoe2, apoe3 and apoe4 transgenic mice." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/76782.

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Анотація:
El Decabromodifenil èter (BDE-209) és un retardant de la flama àmpliament utilitzat i font de preocupació a causa de la toxicitat mostrada per altres Difenil Èters Polibromats (PBDEs). La presència de PBDEs en la llet materna fa preocupant la seva exposició durant el desenvolupament. Pensem que l’exposició primerenca a BDE-209 pot produir efectes a llarg termini i interactuar amb factors genètics, com el genotip de l’ApolipoproteinaE. Ratolins portadors de les diferents isoformeshumanes de l’ApoE foren tractats amb una dosi oral aguda de 0, 10 o 30 mg / kg de BDE-209 en el dia postnatal 10 i
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3

Cambon, Karine. "Influence of ApoE polymorphism on synaptic morphometry during aging in the dentate gyrus of ApoE knockout and human ApoE transgenic mice." Thesis, [n.p.], 2000. http://oro.open.ac.uk/19118/.

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4

Lundbäck, Daniel. "Alkoholkonsumtion och episodiskt minne.Kan APOE genen vid olika konsumtionsnivåer ha betydelse?" Thesis, Stockholms universitet, Psykologiska institutionen, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-88448.

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Анотація:
I denna studie undersöktes om relationen mellan alkoholkonsumtion och episodiskt minne skiljer sig beroende på vilken allele av APOE genen en person har. Undersökningsdeltagarna delades upp i fyra grupper, medelålders män, medelålders kvinnor, äldre män och äldre kvinnor. Utbildningsnivå och ålder inom varje åldersgrupp användes som kovariat. APOE delades upp på 4 bärare och icke bärare. Några signifikanta interaktionseffekter mellan alkoholkonsumtion och APOE framkom inte i någon grupp. I gruppen medelåldersmän hittades en signifikant huvudeffekt av alkoholkonsumtion, där de som avstod från
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5

Hua, Jennifer. "Rôle des récepteurs P2X4 dans la dégradation d’ApoE : implication dans la maladie d’Alzheimer." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT021/document.

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Анотація:
Les récepteurs purinergiques P2X4 (P2X4R) sont des récepteurs canaux exprimés par lesneurones et les microglies du système nerveux central et sont impliqués dans de nombreuxprocessus physiologiques et pathologiques. Des études préliminaires, menées au sein dulaboratoire, ont permis de mettre en évidence une interaction entre P2X4R etl’Apolipoprotéine E (ApoE), ainsi qu’une augmentation d’ApoE dans les macrophages et lesmicroglies provenant de souris déficientes pour P2X4R. Basée sur ces observations, lapremière partie de cette thèse a cherché à caractériser les mécanismes impliquant P2X4R dans
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6

Wassef, Hanny. "Synthesis and secretion of apoC-I and apoE by human SW872 liposarcoma cells." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82447.

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Анотація:
Apolipoprotein C-I (apoC-I) plays an important role in the metabolism of plasma triglyceride levels and cholesterol metabolism. Little is known about the regulation of apoC-I production by human adipocytes. Aim. To investigate the effect of different tissue culture conditions on the synthesis and secretion of apoC-I and apoE in human SW872 liposarcoma cells and to study the effects of apoC-I overexpression in these same cells. Methods. SW872 cells were grown in DMEM/F-12 (3:1, v/v). QPCR was used to quantify mRNA synthesis. ELISAs were used to quantify intracellular and extracellular pr
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7

Sleiman, Lyne. "The Role of cIAP2 in Early and Late Atherosclerosis Lesion Development." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20226.

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Анотація:
Cellular Inhibitor of Apoptosis 2 (cIAP2) belongs to the IAP family, a group of endogenous proteins that inhibit apoptosis. However, the physiological role of cIAP2 remains poorly defined. Knock-out (KO) and wild type (WT) mice were used to examine the effect of cIAP2 protein on the progression of atherosclerosis in apoE -/- mice. Following the high-fat diet period of 4 and 12 wks, tissues were harvested and analysis focused on the aortic root, the aortic arch, the descending aorta, and the blood. Ex vivo results show a significant decrease in aortic arch lesion area in KO vs. WT in both study
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8

D'EUGENIO, Ottavio. "VALUTAZIONE DI FATTORI DI RISCHIO GENETICI SU BASE POLIMORFICA NELLA MALATTIA DI ALZHEIMER." Doctoral thesis, La Sapienza, 2006. http://hdl.handle.net/11573/917163.

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9

Evans, Vanessa. "Intramuscular gene transfer of apolipoprotein E (ApoE) to reverse hyperlipidaemia and atherosclerosis in ApoE-deficient mice." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444704/.

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Анотація:
Plasma ApoE has multiple atheroprotective actions, including clearance of cholesterol-rich remnant lipoproteins, and is an attractive gene therapy candidate to treat atherosclerosis. Here, I focus on the single intramuscular injection of an ApoE-expressing vector, non-viral DNA (plasmid) or adeno-associated virus (AAV), as a safe and effective treatment to alleviate hypercholesterolaemia and atherosclerosis in ApoE-deficient (ApoE" ") mice. Firstly, I constructed expression plasmids harbouring human ApoE3 cDNA, driven by two muscle-specific (CK6 and C512) and one ubiquitous (CAG) promoter. The
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10

Rantsi, P. (Petra). "Apoe 4-alleelien rooli saamelaisväestön muistisairauksissa." University of Oulu, 2017. http://urn.fi/URN:NBN:fi:oulu-201711083079.

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Анотація:
Alzheimerin tauti (AT) on yleisin etenevä muistisairaus. Eteneviin muistisairauksiin luetaan myös aivoverenkiertosairauden muistisairaus, Lewyn kappale- patologiaan liittyvät aivoja rappeuttavat sairaudet ja otsa-ohimolohkorappeumat. Elimistön rasva- aineenvaihduntaan liittyvän apolipoproteiini E4- (ApoE4) alleelin on todettu olevan sydän- ja verisuonisairauksien, kuten myös AT:n myöhemmällä iällä alkavan muodon geneettinen riskitekijä. ApoE4-alleelin yhteyttä muihin eteneviin muistisairauksiin ei ole osoitettu. Vaikka ApoE4:n roolia muistisairauksien ja etenkin AT:n riskitekijänä on tutkittu
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11

Carvalho, Liliana Patrícia Rodrigues de. "Genetic profiling of ApoE in dementia." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10720.

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Mestrado em Biomedicina Molecular<br>A demência é uma das principais causas de incapacidade entre os idosos, afetando mais de 36 milhões de pessoas em todo o mundo. É caracterizada pela deterioração progressiva das funções cognitivas, resultando em dificuldades no desempenho das atividades diárias do indivíduo. A idade de aparecimento dos sintomas, bem como a sua taxa de progressão, são variáveis entre a maior parte das demências, sendo estas geralmente caracterizadas por uma natureza progressiva, aumentando de gravidade ao longo do tempo. Entre os tipos mais frequentes de demência enco
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12

Wong, Clement Cheuk Man. "Plasma Apolipoprotein E Concentration In Type 2 Diabetes." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20997.

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Анотація:
As one of the most important proteins in human lipid metabolism, apolipoprotein E (apoE) is also one of the most well studied apolipoproteins. ApoE has an undisputable role in the plasma clearance of atherogenic triglyceride-rich lipoproteins via receptor-mediated hepatic uptake. For years, apoE has been touted to play a protective role in atherosclerosis. Both quantitative and qualitative changes of apoE are well-known to cause a number of rare dyslipidaemia syndromes. Until recent times, research efforts have mainly focused on the discovery of the differential risk of atherosclerotic vascul
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13

ROSSI, K. B. "Participação da Apolipoproteína-e na Atividade Microbicida in Vitro Contra o Mycobacterium Tuberculosis." Universidade Federal do Espírito Santo, 2014. http://repositorio.ufes.br/handle/10/4582.

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Анотація:
Made available in DSpace on 2016-08-29T15:34:59Z (GMT). No. of bitstreams: 1 tese_8103_Dissertação Kaymerê Final Corrigida.pdf: 1721673 bytes, checksum: 349a8b28df3024da428191034c651c47 (MD5) Previous issue date: 2014-08-29<br>A parede celular de Mycobacterium tuberculosis (Mtb) é constituída por 60% de lipídios, impedindo a passagem de uma grande quantidade de substâncias, além de desempenhar um importante papel na munopatogênese. A apresentação desses antígenos aos linfócitos se dá por meio de moléculas do tipo CD1. Por sua vez a Apolipoproteína-E (ApoE), glicoproteína amplamente distribu
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14

Stening, Eva. "The Influence of APOE ε4 on the Hippocampus and Hippocampus-Dependent Memory". Doctoral thesis, Uppsala universitet, Institutionen för psykologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-302855.

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Анотація:
APOE ε4 is the major genetic risk factor for Alzheimer’s disease, a dementia characterized by memory impairment and hippocampal atrophy. While associated with episodic impairment and reduced hippocampal volume in healthy aging, APOE ε4 has been related to increased episodic memory performance in young adults. The effect of APOE ε4 on hippocampal volume in young age is uncertain, with studies showing comparable or smaller volumes in ε4 carriers. This thesis aims to further explore the effects of APOE ε4 on episodic memory and hippocampal volume in young adults. In addition to episodic memory, s
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15

Elam, Kit. "MEMORY AND DEFAULT NETWORK ACTIVATION AS A FUNCTION OF APOE GENOTYPE." OpenSIUC, 2010. https://opensiuc.lib.siu.edu/dissertations/204.

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Анотація:
The main purpose of this dissertation project was to assess the behavioral and neural correlates of Episodic Memory as a function of the APOE genotype in a healthy young adult sample. To accomplish this, 98 subjects completed behavioral tasks assessing visual memory, working memory, episodic memory, and attention. Subjects also completed questionnaires evaluating IQ, years of education, drug use, personality, and emotional traits. These subjects were also genotyped for the APOE gene, resulting in 29 APOE-ε4 carriers (subjects who had at least one ε4 allele) and 69 Non APOE-ε4 carriers (having
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16

Damy, Sueli Blanes. "Associação entre infecção experimental por Mycoplasma pneumoniae e/ou Chlamydophila (Chlamydia) pneumoniae e a intensidade das lesões ateroscleróticas da aorta, em camundongos C57BL/6 apoE KO, com ênfase na diferença entre os sexos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-16042007-121022/.

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Анотація:
Os mecanismos pelos quais os agentes infecciosos, independentes ou não de meio ambiente permissivo, podem promover a aterogênese e as manifestações clínicas não estão completamente esclarecidos. Apesar das numerosas publicações demonstrando a presença de antígenos ou DNA de agentes infecciosos nas placas de ateroma, a questão se o agente infeccioso pode iniciar o processo aterosclerótico ou agravá-lo permanece sem resposta, possibilitando o aprofundamento das pesquisas neste assunto. Desta forma, este trabalho tem como objetivo estudar se a infecção experimental, por C.pneumoniae e/ou M.pneumo
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17

DAL, MAGRO ROBERTA. "Enhanced brain targeting of ApoE-functionalized lipid nanoparticles." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/103191.

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Анотація:
The blood-brain barrier (BBB) plays an important role in maintaining the homeostasis of the central nervous system and in protecting the brain from potentially harmful endogenous and exogenous compounds. Nevertheless, it represents also the major obstacle for the diagnosis and therapy of brain diseases. One of the most promising strategies to overcome the limited BBB penetration of drugs and contrast agents is based on nanoparticles (NP). Lipid based NP, mainly liposomes (LIP) and solid lipid nanoparticles (SLN), have several advantages in terms of biocompatibility, non-immunogenicity, non-tox
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18

Martinic, Goran (Gary), of Western Sydney Hawkesbury University, of Science Technology and Environment College, and School of Environment and Agriculture. "Cyclodextrins as potential human anti-atherosclerotic agents." THESIS_CSTE_EAG_Martinic_G.xml, 2001. http://handle.uws.edu.au:8081/1959.7/129.

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Анотація:
Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides. Since it is believed that OxC blocks the removal of normal cholesterol from cells in the artery wall, it is possible that selective removal of OxC in the vessel wall in-vivo may prevent or reverse atherosclerosis.As a prelude to major studies, this research project was designed to answer two critical questions; 1/. What is the best route for delivery of CD. 2/. How do animals (apoE-/- mice) tolerate it. Pilot studies were established and results noted. These studies have provided valuable information in the apoE-/- mouse for
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19

Hussain, Aseem. "Beneficial effects of estradiol are mediated through apoE /." View online, 2008. http://repository.eiu.edu/theses/docs/32211131425346.pdf.

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20

Trachtenberg, Aaron J. "The effects of APOE genotype on brain function." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542982.

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21

Xie, Ting. "Interactions épistatiques et modifications épigénétiques pour la stratification moléculaire des maladies chroniques." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0339/document.

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Анотація:
Les maladies chroniques, comme les maladies cardiovasculaires (MCV), la maladie d'Alzheimer (AD), la dépression et l'ostéoporose, sont les principales causes de mortalité dans le monde. L'identification de facteurs de risque communs à ces maladies pourrait contribuer à un vieillissement «sain» mieux surveillé en utilisant des stratégies personnalisées de prédiction des risques, de prévention précoce et de traitement adéquat, en tenant compte des comorbidités très souvent existantes. Dans cette thèse, 8 publications ont été développées. Dans un premier temps, j'ai résumé, dans un article de rev
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22

Nielsen, Henrietta M., Kewei Chen, Wendy Lee та ін. "Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism". BIOMED CENTRAL LTD, 2017. http://hdl.handle.net/10150/622812.

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Анотація:
Background: Carriers of the APOE epsilon 4 allele are at increased risk of developing Alzheimer's disease (AD), and have been shown to have reduced cerebral metabolic rate of glucose (CMRgl) in the same brain areas frequently affected in AD. These individuals also exhibit reduced plasma levels of apolipoprotein E (apoE) attributed to a specific decrease in the apoE4 isoform as determined by quantification of individual apoE isoforms in APOE epsilon 4 heterozygotes. Whether low plasma apoE levels are associated with structural and functional brain measurements and cognitive performance remains
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23

Blanchard, Valentin. "Approches biochimique, épidémiologique et clinique du métabolisme intégré de la Lipoprotéine (a)." Thesis, La Réunion, 2020. http://www.theses.fr/2020LARE0007.

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Une personne sur cinq dans la population générale présente des niveaux plasmatiques élevés en lipoprotéine (a) [Lp(a)], une lipoprotéine extrêmement athérogène qui ressemble aux LDL. Les études physiopathologiques, épidémiologiques, et génétiques démontrent que lorsque la concentration sanguine en Lp(a) dépasse 125 nmol/L, la survenue d’événements cardiovasculaires augmente très fortement. La différence structurale majeure entre Lp(a) et LDL est que la Lp(a) contient une protéine caractéristique supplémentaire, l’apo(a), de taille très variable car elle contient entre 1 et 40 répétitions du do
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24

GARCIA, Analia Nusya de Medeiros. "Polimorfismos dos genes CYP 46 e APOE e declínio cognitivo em idosos residentes no distrito de Fernando de Noronha-PE." Universidade Federal de Pernambuco, 2011. https://repositorio.ufpe.br/handle/123456789/8317.

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Анотація:
Made available in DSpace on 2014-06-12T22:59:08Z (GMT). No. of bitstreams: 2 arquivo5593_1.pdf: 9647965 bytes, checksum: 23ac0509ddb6353a3c91975edec8f243 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2011<br>O Declínio Cognitivo Leve (DCL) é um estado mental considerado a zona de transição entre o envelhecimento normal e a fase mais inicial de demência, sendo uma fase importante para a precocidade diagnóstica. Nos últimos anos, pesquisas estão sendo desenvolvidas na busca de marcadores genéticos para esta zona de pré-demência, como os
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25

Coppens, Ryan Patrick. "ApoE4 Genotype as a Moderator of Brain Responses to Target Stimuli Prior and Subsequent to Smoking Abstinence." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/dissertations/1494.

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Анотація:
A growing body of research is targeted towards characterizing and explaining nicotine’s complex interactions with the ApoE E4 allele on brain responses underlying cognitive processes. However, when and how the ε4 allele modulates neuroelectric brain responses in the presence of nicotine versus nicotine abstinence in nicotine-dependent smokers is not well characterized. Being able to understand this modulation is potentially quite important given that recent research implies that, relative to non-ε4 carriers, young adult carriers of the ε4 allele exhibit greater cognitive benefits from the us
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26

Ferguson, Chantal M. "Modulating ApoE with Tissue Specific siRNAs in Alzheimer’s Disease." eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1132.

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Анотація:
Among many putative genetic risk variations reported to date, the ApoE4 allele remains the most common genetic risk factor for late-onset AD, and is associated with both an increase in incidence and a decrease in age of clinical onset. The majority of ApoE is produced in the: 1) central nervous system (CNS) by astrocytes to transport lipids between cells and modulate the inflammatory response; and 2) liver, where it facilitates lipid uptake into peripheral tissues via low-density lipoprotein (LDL) receptors. Consistent with its dual roles, genetic knockout of ApoE increases the risk for athero
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27

Sinclair, Lindsey Isla. "Molecular and life-course aspects of APOE in cognition." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701968.

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Анотація:
Dementia has a devastating effect on patients and those around them. Alzheimer's disease (AD) is the most common form of dementia. There is no cure and the prevalence may increase as much as fourfold by 2050. Variation in the APOE gene is the best-known genetic risk factor for AD. There is evidence to suggest that changes are evident in those with the high-risk Ɛ4 variant decades before AD develops. The exact nature of these changes, timing and their effect on brain structure and function is not clear. Another variant, the Ɛ2 variant seems to protect against AD but again the mechanism is uncle
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28

Szostak, Justyna. "Activité physique et prévention de l'arthérosclérose : Mise en évidence de l’implication des PPAR (Peroxisome Prolife- raor-Activated Receptor) dans la cardioprotection induite par l’exercice physique soumis ou volontaire chez la souris ApoE-/- mice." Thesis, Besançon, 2012. http://www.theses.fr/2012BESA3006/document.

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L‟athérosclérose est un processus inflammatoire chronique à l‟origine des accidents cardiovasculaires quiconstitue l‟une des premières causes de mortalité en France. L‟inflammation est le facteur essentiel dansl‟initiation, la progression et l'instabilité des lésions athéromateuses à l‟origine des accidents aigus. Lesdonnées récentes suggèrent que l‟activation des récepteurs nucléaires PPAR (Peroxysome-ProliferatorActivated Receptor) par des ligands pharmacologiques prévient le développement et la progression del‟athérosclérose et diminue de manière importante la mortalité cardiovasculaire. À
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29

Cieslak, Stephen Gerard. "The Effects of L-Cysteine on Alzheimer's Disease Pathology in APOE2, APOE3, and APOE4 Homozygous Mice." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6585.

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Анотація:
The APOE gene is of profound importance regarding the onset of Alzheimer's disease (AD). From the small physical differences among the protein products of the isoforms of this gene arises a profound difference in their physiologies. For example, the APOE2 isoform confers resistance to AD, the APOE3 isoform confers neutral susceptibility to AD, and the APOE4 isoform confers proneness to AD. L-cysteine is an amino acid that has several anti-AD properties, among which are its ability to sequester iron and form glutathione – a powerful antioxidant – and therefore may be a promising potential dieta
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30

Bouchareychas, Laura. "Implication des phagocytes mononuclées dans l'évolution de la plaque d'athérosclérose et relation avec l'homéostasie du cholestérol et des lipoprotéines." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066282/document.

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Анотація:
L'athérosclérose est un processus physiopathologique chronique impliqué dans la majorité des maladies cardio-vasculaires. Le développement des lésions d'athérosclérose est caractérisé par l'accumulation de lipides extra et intracellulaires dans la paroi artérielle à l'origine d'une forte réponse inflammatoire impliquant notamment les macrophages. Les macrophages sont considérés comme des acteurs clés dans le développement des plaques d'athérosclérose. En effet, de par leur capacité à métaboliser le cholestérol (captation, stockage, efflux), à réguler l'inflammation et à phagocyter les cellules
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31

McCorkindale, Andrew Neil. "Investigating the pathogenesis of Alzheimer’s disease with machine learning." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29764.

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Анотація:
Alzheimer’s disease (AD) affects millions worldwide, but there are no effective treatments. AD is defined by the initial accumulation of amyloid plaques before the formation of neurofibrillary tangles of tau protein leads to neurodegeneration. Multiple clinical trials directed at amyloid have not shown clinical benefits. Further research into the mechanisms of AD is necessary to identify other potential drug targets. Transcriptomic analysis is a powerful approach for studying mechanisms, but the commonly used methods have limitations such as a vulnerability to outliers. Machine learning (ML) a
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32

Haskett, Darren. "Progressive Alterations in Microstructural Organization and Biomechanical Response in the ApoE Mouse Model of Aneurysm and the Underlying Changes in Biochemistry." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/581126.

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Abdominal Aortic Aneurysm (AAA) is a complex disease that leads to a localized dilation of the infrarenal aorta that develops over years. Longitudinal information in humans has been difficult to obtain for this disease, therefore mouse models have become increasingly used to study the development of AAAs. The objective of this study was to determine any changes that occur in the biomechanical response and fiber microstructure in the apolipoprotein E difficient (ApoE-/-) angiotensin II (AngII) infused mouse model of aneurysm during disease progression, as well as determine some of the underlyin
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33

CAMPOREZ, D. "BIOMARCADORES de Diagnóstico Complementar na Doença de Alzheimer: Enfoque em Genes Que Participam da Formação da Placa Beta-amiloide,via do Folato e Geração de Estresse Oxidativo." Universidade Federal do Espírito Santo, 2018. http://repositorio.ufes.br/handle/10/7147.

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Made available in DSpace on 2018-08-01T21:35:22Z (GMT). No. of bitstreams: 1 tese_12342_Tese - Daniela Camporez.pdf: 1833396 bytes, checksum: 82e9b25850d00808ee295c7a2313f773 (MD5) Previous issue date: 2018-06-06<br>A doença de Alzheimer (DA), é o tipo mais comum de demência relacionada a idade. É uma doença neurodegenerativa crônica, grave, progressiva, associada à perda de memória e cognição, que pode levar à morte. O maior fator de risco para o desenvolvimento da doença é a idade avançada, com uma complexa interação de fatores ambientais e genéticos que juntos podem aumentar a incidência
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34

Li, Xiaojing. "Relating Brain Signal Complexity, Cognitive Performance and APOE Polymorphism – the Case of Young Healthy Adults." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21383.

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Das menschliche Gehirn ist ein komplexes System, dessen Komplexität von großer funktioneller Bedeutung. Das APOE ɛ4 Allel ist ein gut untersuchter genetischer Risiko-Faktor für die Ausbildung der Alzheimer’schen Demenz. Das wesentliche Ziel dieser Dissertation ist die Untersuchung der Verbindungen zwischen der Komplexität von Hirn-Signalen, APOE-Genotyp und kognitiver Leistung bei jungen gesunden Erwachsenen unter dem Gesichtspunkt individueller Unterschiede. Nachdem ich in der ersten Studie die Reliabilität der Residual Iteration Decomposition (RIDE), einer Methode zur Analyse von Gehirnsigna
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35

Harris, Julian David. "Development of recombinant adeno-associated virus and second generation adenovirus vectors for the gene transfer of human apolipoprotein E (ApoE) in the APOE deficient mouse." Thesis, Royal Holloway, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420867.

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36

Filho, Sebastião Barreto de Brito. "Efeito da ingestão crônica de vinho sobre a homeostase glicêmica, lipídica e ponderal em camundongos ApoE Knockout." Universidade do Estado do Rio de Janeiro, 2013. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6770.

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Os benefícios à saúde relacionados ao consumo moderado de vinho incluem diferentes mecanismos, nos quais estão envolvidos tanto etanol quanto compostos fenólicos que são constituintes do mesmo. Com o objetivo de avaliar variações glicêmicas, ponderais e o depósito de triglicérides, colesterol e glicogênio hepáticos com uso regular de vinho tinto em camundongo ApoE Knockout, foram utilizados 60 camundongos machos adultos ApoE Knockout de peso médio de 30 gramas, distribuídos em três grupos de 20 animais: grupo vinho, grupo etanol e grupo água, os quais receberam 50 mL de vinho e 50 mL água, 6mL
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37

Wadas, Theresa M. "Relationships among APOE Genotypes, Inflammatory Markers, and Risk Factors among African Americans with Ischemic Stroke." Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/556235.

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African Americans experience a disproportionate mortality, morbidity, and disability associated with ischemic stroke. Traditional risk factors offer some explanation for this finding, but novel risk factors have not been explored. APOE4 genotype, which is more prevalent in African Americans demonstrate a pro-inflammatory phenotype that may result in an exaggerated inflammatory response associated with ischemic stroke, resulting in worse outcomes. The purpose of this study was to examine relationships among APOE genotypes, inflammatory markers (CD11β, platelet leukocyte aggregates, IL-1β, IL-6,
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38

Obregon, Tito Alexandra de. "APOE haplotypes in health, lessons from an Oklahoman African American population." Oklahoma City : [s.n.], 2010.

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39

Naumann, Sandy. "Gen-Umweltinteraktion bei alkoholabhängigen Patienten am Beispiel von ApoE und Homocystein." kostenfrei, 2009. http://d-nb.info/999863649/34.

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40

Young, Elizabeth. "HDL-apoE content regulates the cell surface displacement of hepatic lipase." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28247.

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Human hepatic lipase (HL) is an interfacial enzyme that must be liberated from cell surface proteoglycans to hydrolyze lipoprotein triglyceride. HDL and apolipoprotein (apo)A-1 can displace HL from cell surface proteoglycans, much like heparin. HL displacement is inhibited by HDL-apoE content. Postprandial HDL is &sim;2-fold better at displacing HL than fasting HDL, but only has about half the apoE content. Enriching native HDL with triglyceride decreases HDL-apoE content and increases HL displacement. In contrast, enriching synthetic HDL with apoE significantly inhibits HL displacement. HDL f
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41

Jiang, Qingguang. "The role of ApoE and liver X receptors in Alzheimer's disease." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1212161307.

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42

Karpe, Britta. "Effekt von Darbepoetin alfa auf die geschädigte Niere am ApoE(-/-)-Mausmodell." kostenfrei, 2008. http://www.opus.ub.uni-erlangen.de/opus/volltexte/2008/1003/.

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43

Dumanis, Sonya Benjamina E. "Using APOE genotypes to identify new biomarkers for Alzheimer's disease risk." Thesis, Georgetown University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3559756.

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<p> Alzheimer's disease (AD), unlike the other leading causes of death, does not have a cure or an effective intervention strategy. The largest genetic risk factor for AD is APOE, with the &epsiv;4 allele increasing and the &epsiv;2 allele decreasing one's risk for the disease. It remains unclear how ApoE isoforms contribute to various AD-related pathological changes (e.g. amyloid plaques, synaptic and neuron loss). Here, we characterize the differences between the at risk group for AD (the &epsiv;4 carriers) and the not-at risk group (non-&epsiv;4 carriers), to determine what underlies APOE-r
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44

Larramona, Arcas Raquel. "ApoE4 pathology in Alzheimer’s disease from the perspective of organelle dysfunction in astrocytes." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/666659.

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La enfermedad de Alzheimer es la forma mas común de demencia en edades avanzadas, la cual afecta a 40 millones de personas alrededor del mundo. Es una enfermedad compleja que afecta no solo a neuronas, sino también a astrocitos. La Apolipoproteína E4 (ApoE4) ha sido descrita como el factor de riesgo genético más importante de la forma esporádica de la enfermedad y además, los astrocitos son los principales secretores de esta. La investigación sobre los mecanismos patogénicos causados por esta apolipoproteína está centrada en su rol extracelular. Por el contrario, nosotros analizamos las desreg
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45

Mathias, Daniel. "Auswirkungen niedrig dosierter ionisierender Strahlung auf inflammatorische Marker des ApoE-/- -Mäuse-Herzens." Doctoral thesis, Universitätsbibliothek Leipzig, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-221195.

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Die Akutfolgen ionisierender Strahlung wurden in zahlreichen Studien gut untersucht, ein Zusammenhang zwischen Hochdosisbestrahlung und deterministischen Spätschäden wurde vielfach belegt. Über die Langzeitfolgen niedrig dosierter ionisierender Strahlung hingegen ist bislang weniger bekannt, obwohl epidemiologische Studien auf ein erhöhtes Risiko strahlenassoziierter Spätfolgen hinweisen, sogar bei sehr geringen Dosen. Ionisierende Strahlung bedingt dosis- und zeitabhängigen Veränderungen in zahlreichen Geweben. Mittlere bis hohe Strahlendosen führen unter anderem zur strahleninduzierten koron
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46

Dikotope, Sekgothe Abram. "Response of serum lipids to a fat meal in Black South African subjects with different apoe genotypes." Thesis, University of Limpopo (Turfloop Campus), 2013. http://hdl.handle.net/10386/1059.

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Thesis (M.Sc. (Chemical Pathology)) --University of Limpopo, 2013<br>Objectives The present study investigated how the serum lipids responded to a high-fat meal in black South African subjects with different APOE genotypes, a population that until recently was reported to be consuming a traditional diet of low fat and high carbohydrates. Methods Sixty students (males and females) of the University of Limpopo, Turfloop Campus were successfully genotyped using Restriction Fragment Length Polymorphism (RFLP) and grouped into four APOE genotype groups; ε2, ε2/ε4, ε3 and ε4. Only thirty-three
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47

Hammoud, Ahd. "Facteurs métaboliques de risque cardio-vasculaire : interaction entre les régimes alimentaires et les polymorphismes de gènes impliqués dans le métabolisme des lipides." Thesis, Aix-Marseille 2, 2010. http://www.theses.fr/2010AIX20702/document.

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Les marqueurs de risque cardio-vasculaire peuvent être améliorés par des recommandations nutritionnelles à l’échelle d’une population, mais la réponse à ces régimes varie entre les individus, variabilité partiellement due aux polymorphismes génétiques. Les objectifs de ce travail étaient d’étudier l’association entre la réponse à un régime suivi pendant 3 mois et certains polymorphismes des gènes de l’apolipoprotéine B (-516C/T) et de l’apolipoprotéine E (epsilon et -219G/T).Le régime alimentaire (diminution des lipides totaux et remplacement des acides gras saturés par des acides gras mono- e
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48

Filippini, Nicola. "Brain structure, function and connectivity associated with APOE genotype : what changes when?" Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.525306.

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49

Farsian, Farnas [Verfasser], and Jörg Heeren [Akademischer Betreuer]. "ApoE Regulates Corticospinal Neuronal Survival Through ApoER2 / Farnas Farsian. Betreuer: Jörg Heeren." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2013. http://d-nb.info/1045024538/34.

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50

McColl, Barry. "Pathophysiology of cerebral ischaemia : effects of APOE genotype on outcome and endocytosis." Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/4324/.

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Apolipoprotein E (apoE denotes protein: APOE denotes gene) is a lipid-transport protein abundantly expressed in the brain and strongly upregulated after acute brain injury. The APOE e4 allele is the major genetic risk factor for Alzheimer’s disease (AD) and has been associated with poorer outcome after various types of acute brain injury, including traumatic brain injury and subarachnoid haemorrhage. However, the role of APOE genotype in focal ischaemic stroke is less clear. The mechanism(s) by which APOE genotype may modulate outcome after acute brain injury are also unclear at present. Accor
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