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Piccolo, Federica <1990>. "Il carteggio apocrifo tra Seneca e San Paolo: rapporti con l'epistolario di Simmaco oratore." Master's Degree Thesis, Università Ca' Foscari Venezia, 2014. http://hdl.handle.net/10579/5492.
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Mullard, Graham. "Metabolomic investigations into human apocrine sweat secretions." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/14452/.
Повний текст джерелаАнотація:
Human axillary odour is formed by the action of Corynebacteria or Stephyloccui bacteria on odourless axilla sections. Several groups have identified axillary odorants, including 3-methyl-2-hexanoic acid (3M2H) and 3-hydroxy-3-methyl-hexenoic acid (HMHA), and how they are pre-formed and bound to amino acid conjugates. However, there is currently a lack of LC-MS methodologies and no reported NMR methods, that are required to further identify the non-volatile constituents, which would provide further information to allow understanding of the underlying physiological biochemistry of malodour. This work has incorporated a three-pronged approach. Firstly, a global strategy, through the use of NMR and LC-MS, provided a complementary unbiased overview of the metabolite composition. Metabolites were identified based on acquired standards, accurate mass and through the use of in-house or online databases. Furthermore, spectra of biological samples are inherently complex, thus, requiring a multivariate data analysis (MVDA) approach to extract the latent chemical information in the data. Secondly, semi-targeted LC-MS/MS methodologies has been used to identify metabolites with a common structural core (i.e. odour precursors) and provide structural information for the reliable identification of known and unknown metabolites. Finally, a targeted LC-MSIMS method provided an increase in specificity and sensitivity to accurately quantify known metabolites of interest (odour precursors). Initially, all methodologies were developed through the use of either an artificial sweat matrix (global strategy) or through the use of synthetic standards (semi-targeted or targeted strategy). The sample complexity was then increased by applying the methodologies to an ASG5 apocrine cell line, in order to provide further knowledge into apocrine cell metabolism and to identify whether there could be any potential male or female differences due to differences in circulating hormones. Changes in the cell metabolism were identified, and both the NMR and LC-MS data could differentiate between control, tamoxifen- and β-estradiol-treated. However, it is difficult to attribute these changes to specific pathways, as these hormones or the vehicle used (ethanol) are likely to produce a ripple effect across the cell's metabolism. Nonetheless, NMR spectroscopy quantified 25 metabolites with lactate being the most abundant at 19.1 mM, while HILIC-MS could detect a range of lipids, nucleotides, amino acids, fatty acids and vitamins. The methodologies were then applied to human apocrine sweat collected from six volunteers across five days. NMR spectroscopy was able to identify 25 and quantify 19 metabolites, with lactate being the most abundant at 13.2 mM. LC-MS/MS readily identified 12 amino acid conjugates with HMHA being the most abundant. Furthermore, a possible 20 unidentified conjugates were detected (LC-MSIMS semi-targeted methodologies) as well as putatively identifying 473 metabolites (LC-MS global methodologies). MVDA techniques such as principal component analysis (PCA) illustrated that intra-individual variation was greater than inter-individual variation, as well as secretions from both the left and right arm being consistent with one another. Moreover, MVDA illustrated the complementary nature of both NMR and MS, as the data acquired with the two types of instrumentation showed the same trends, even though these trends were based on different subsets of metabolites. The work presented herein, has successfully used a number of analytical technologies to investigate metabolite content of human apocrine sweat. It has been shown that a number of complementary techniques and multivariate analysis can provide a valuable insight into the underlying physiology of malodour.
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Višnevskij, Vladislav. "Smaugtapilviai plėvesparniai (Hymenoptera: Apocrita) iš geltonųjų (Moericke) gaudyklių." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20090908_193906-36802.
Повний текст джерелаАнотація:
Šio darbo tikslas – įvertinti smaugtapilvių plėviasparnių įvairovę Dzūkijos Nacionalinio parko buveinėse. Atlikus skaičiavimus buvo gauti tokie rezultatai: 1. Daugiausiai teigiamų koreliacijų tarp plėviasparnių ir buveinių buvo atrasta su spygliuočių ir mišriu mišku. Daugiausiai neigiamų – aukštapelke. Su augalų gyvenimo formomis ir plėviasparnių grupėmis daugiausiai teigiamų koreliacijų yra su žolėm. Plėviasparnių gausumo ryšys yra ne stiprus, todėl manoma, kad augalų gyvenimo formos ir buveinių tipai nėra pagrindinis veiksnys, lemiantis plėviasparnių pasiskyrstymą. 2. Didžiausia smaugtapilvių plėviasparnių grupių įvairovė nustatyta 2005 m. pievoje (aptikta 16 grupių, N1= 5,43, N2= 3,9). 3. Didžiausia įvairovė visoms buveinėms nustatyta birželio ir rugpjūčio mėnesiais. Žemapelkėje ir aukštapelkėje yra pastebimas antras įvairovės pikas – rugpjūtį. . Mišriame, spygliuočių miške ir pievoje įvairovė vėl pakyla nuo liepos vidurio iki rugsėjo. Smaugtapilvių plėviasparnių įvairovės kitimas sezone skirtingais metais yra dėsningas. 4. Pagal turimus duomenys įvairovė žėmapelkėje, spygliuočių ir mišriame miške 2003 – 2004 m. mažėja..The aim of the study was to mesuare ivairovė of hymenoptera in National park of Dzūkija. Observations were carried out in various habitants of National park of Dzūkija in 1998, 2003, 2004, 2005 yers. For this purpose Moericke traps were used. In 2005 3020 individuals were cought. Most of them (1116 individuals ) belong to subfamily Ichneumoninae. According to calculations, in most habitants diversity is decreasing. In 2005 yer bigest diversity was in fen (N1 = 5,43, N2 = 3,9). In difrent years diversity change is similar. Bigest diversity in all habitants was noticed in june. In forest and in fen diversty is also high from mid july till september, in swamp – in august. Correlation results with vegetation and habitants were very weak, what can mean, that these are not the mane factors for Hymenoptera distribution.
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Sharanowski, Barbara J. "HYMENOPTERAN MOLECULAR PHYLOGENETICS: FROM APOCRITA TO BRACONIDAE (ICHNEUMONOIDEA)." Lexington, Ky. : [University of Kentucky Libraries], 2009. http://hdl.handle.net/10225/1013.
Повний текст джерелаАнотація:
Thesis (Ph. D.)--University of Kentucky, 2009.Title from document title page (viewed on July 28, 2009). Document formatted into pages; contains: viii, 113 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 101-111).
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El-Ayat, Ghada Mohamed Atef. "Molecular abnormalities in apocrine metaplasia of the female breast." Thesis, Queen Mary, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431765.
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Paraizo, Júnior Elias Santos do. "O Pedro ulterior." reponame:Repositório Institucional da UFSC, 2014. https://repositorio.ufsc.br/xmlui/handle/123456789/135977.
Повний текст джерелаАнотація:
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da Tradução, Florianópolis; Belo Horizonte, 2014.Made available in DSpace on 2015-11-03T03:04:43Z (GMT). No. of bitstreams: 1 335700.pdf: 10074295 bytes, checksum: 5b653807bba2610d9cc9a43baea099d9 (MD5) Previous issue date: 2014
Esta tese tem por objetivo apresentar a tradução anotada e comentada do livro ?apócrifo? ? Atos de Pedro, obra que nos restou fragmentada nas línguas: copta, latim e grego. Para realizar tal intento procurou-se enfocar diferentes aspectos do conceito de tradução para textos sagrados, assim como as suas implicações exegéticas e tradutórias. Serviram de guia para esta tese os pressupostos teóricos de: Friedrich Daniel Ernst Schleiermacher, Eugene Albert Nida, Antoine Berman, Lawrence Venuti, e Ernst-August Gutt. A tradução é oferecida em dupla coluna: primeiramente, os textos fragmentários copto-greco-latino, comparados os fac-símiles dos manuscritos com as edições críticas de Léon Vouaux (1922), Carl Schmidt (1903); Donatien de Bruyne (1908), com respectivos aparatos críticos; na segunda coluna, a tradução em português acompanhada de comentários. Esta tese, também analisa questões como, e.g.: tradução e exegese bíblica, tradução de escritos apócrifos do ambiente cristão primitivo e literatura cristã na Antiguidade, e dentre estes, com proeminência ao valor do elemento ?gnoses? na leitura e, consequente tradução, desses textos advindos do cristianismo nascente. No labor tradutório deu-se preferência ao alcance do contexto histórico assentado à luz da crítica ? foi usado o método exegético histórico-crítico.
Abstract : This thesis has as proposal: the annotated translation with commentary of the ?apocryphal? text ? Acts of Peter, a work left to us in fragmented language: Coptic, Latin and Greek. To accomplish this purpose we sought to focus on different aspects of the concepts of translation of sacred texts, as well as their exegetical and translational implications. This served as a guide for this thesis the theoretical assumptions of: Schleiermacher (F.), Nida (E.), Berman (A.), Venuti (A.) and Gutt (E-A.). The translation presented in this dual column: firstly, the fragmentary texts Coptic-Greek-Latin compared the facsimiles of manuscripts to the critical editions of Vouaux (L.; 1922), Schmidt (C.; 1903); Bruyne (D.; 1908), with their critical apparatus; in the second column, the Portuguese translation accompanied by comments. However, this thesis also examines issues such as, for example: biblical translation and exegesis, translation of apocryphal texts environment arising from the early Christian and Christian literature in Antiquity, and one of these, with prominence to the value of the element 'gnosis' in reading and, consequently, translation of these texts from early Christianity. In translational work gave preference to the scope of historical context along by the light of criticism - we used the historical-critical Exegetical method.
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Dell'Olio, Noemi <1993>. "Analisi di una rassegna teatrale: "Mille di queste notti 2018" della Bottega degli Apocrifi." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/14413.
Повний текст джерелаАнотація:
La mia tesi di laurea tratta l’analisi di un evento culturale, nello specifico della rassegna teatrale estiva “Mille di queste notti: Shakespeare ai contadini”, realizzata dalla compagnia teatrale Bottega degli Apocrifi,in collaborazione con la cooperativa Terra Terra, animata dal team Vàzapp.
Analizzando in primis tutte le attività teatrali della compagnia, dalla programmazione annuale, ai laboratori teatrali e musicali, alle produzioni principali degli ultimi anni, mi occupo, in secundis, di approfondire quest’evento che si svolge nei 3 mesi estivi in ambientazioni open space e storiche: cascina Savino e le antiche mura delle città, rispettivamente di Foggia e Manfredonia. Le rappresentazioni portate in scena trattano principalmente temi socialmente impegnati e letteratura Shakesperiana, il tutto arricchito da musica dal vivo e da degustazione gastronomica.
Shakespeare ai contadini è un progetto che si prospetta di portare cultura e relazioni nelle periferie, attraverso l’esperienza culturale a 360 gradi, che unisce patrimonio storico, enogastronomico ed architettonico del territorio pugliese.
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Roy, Alain 1968 May 11. "Phylogenetic study of Apocrita (Hymenoptera) with emphasis on wing venation." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23422.
Повний текст джерелаАнотація:
A phylogenetic character analysis of the wing venation within Apocrita (Hymenoptera) was conducted in order to examine the phylogenetic significance of wing characters. The venational data were then combined with published studies of other character suites to produce a hypothesis of phylogenetic relationships among apocritan superfamilies and families. Whereas the cladograms obtained from the collection of papers on character suites provide strong support for the sister group relationship between Orussidae and Apocrita, the ones derived from wing venation did not establish such a relationship, although they provided more support for relationships within Apocrita. A ground plan is proposed for the wing venation of each taxon examined; for Apocrita, it is close to the groundplan established for Aculeata. The variability of wing venation is higher between and within apocritan taxa than in Symphyta. This research confirms that groupings such as the Symphyta, Siricoidea, Evanioidea and possibly the Proctorupoidea are artificial.
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Freeman, Klaire E. "The Effects of Urban Land Use on Wasps (Hymenoptera: Apocrita)." Cleveland State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=csu1363613906.
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Jacks, Duncan. "Apocrine secretion in the mouse epididymis and rat and human vas deferens." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33783.
Повний текст джерелаАнотація:
Over the years, epithelial cells of the male reproductive tract have been suggested to be involved in apocrine secretion. However, this method of secretion has not been fully accepted, nor is it well understood. In the present study, apocrine secretion was examined in the mouse epididymis and rat and human vas deferens. Throughout these regions of the duct, the apex of the epithelial principal cells often shows protrusions extending towards the lumen of the duct, referred to as apical blebs (ABs). Of different shapes and sizes, ABs appear to form at the apex of principal cells, and morphological and immunocytochemical evidence suggests that ABs detach from the cell surface whereupon they eventually undergo fragmentation in the lumen. ABs contain selective organelles suggesting a segregation of their contents. Numerous polysomes suggest the synthesis of nonglycosylated proteins which upon the fragmentation of ABs in the lumen could act directly or indirectly on sperm. The presence of spherical vesicles of various sizes (20--200mn) within ABs as well as within the lumen of the duct supports AB fragmentation in the lumen and may play a role in modifying the sperm surface. Taken together the data provide strong evidence for apocrine secretion that could play important roles in relation to sperm maturation, viability and protection.
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Bundred, Nigel James. "The objective identification of apocrine change in benign and malignant breast disease." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241376.
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Carvalho, Gabriela Karine Rocha de. "Alguns himenÃptera Apocrita do Membro Crato (Aptiano) da FormaÃÃo Santana, Bacia do Araripe." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16904.
Повний текст джерелаАнотація:
CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel SuperiorO presente trabalho descreve novos espÃcimes de himenÃpteros provenientes dos calcÃrios laminados do Membro Crato (Aptiano) da FormaÃÃo Santana, Bacia do Araripe, aflorantes no municÃpio de Nova Olinda, sul do Estado do CearÃ. TambÃm sumaria as diversas ocorrÃncias de himenÃpteros fÃsseis, destacando as eocretÃceas. O estudo de dez exemplares de Hymenoptera Apocrita aqui descritos revelou a ocorrÃncia de trÃs famÃlias: Sphecidae (Cretosphex magnus Darling 1990 e C. parvus Darling 1990), Sapygidae (Cretofedtschenkia santanensis Osten 2007) e Evaniidae, esta representada por um gÃnero e espÃcie novos. Na Bacia do Araripe, a subordem Symphyta à pouco comum, e os Apocrita sÃo mais diversificados, com os Parasitica reunindo formas de Ichneumonoidea, âEphialtitidae, Proctotrupidae, âMesoserphidae e Evaniidae, e os Aculeata com espÃcies de Sphecidae (os mais abundantes), Sapygidae, Rhopalosomatidae, Scoliidae, Tiphiidae, Vespidae e possivelmente Formicidae. Ao longo de sua histÃria geolÃgica, os himenÃpteros sÃo principalmente representados por vespas. A partir do JurÃssico sÃo insetos relativamente comuns, apresentando um longo perÃodo de grande diversificaÃÃo (do NeojurÃssico ao TerciÃrio), quando surgiram mais de 80% de todas as 107 famÃlias com registro fÃssil atualmente conhecidas. A extinÃÃo que afetou os organismos de modo geral ao final do CretÃceo parece tambÃm ter afetado os himenÃpteros, que mostram o maior nÃmero de famÃlias extintas por perÃodo geolÃgico de sua histÃria. Os himenÃpteros do Membro Crato estÃo preservados por substituiÃÃo mineral, articulados, com asas abertas e pernas extendidas, mostrando maior nÃmero de espÃcimes fÃmeos do que machos, sem larvas conhecidas. à uma fauna bastante distinta das principais himenopterofaunas eocretÃceas conhecidas (Espanha, MongÃlia, AustrÃlia e SibÃria), nÃo compartilhando nenhum gÃnero, mas tendo como caracterÃstica em comum a pequena participaÃÃo dos Symphyta. A histÃria da pesquisa dos himenÃpteros cretÃceos no Brasil mostra que a maioria e os mais significativos trabalhos tÃm sido efetuados por pesquisadores estrangeiros, de modo que a maior parte dos exemplares de Hymenoptera provenientes do Membro Crato da Bacia da Araripe encontra-se atualmente fora do Brasil, tornando-se necessÃrio que os paleontÃlogos brasileiros assumam o estudo desta ordem de insetos ocorrente na FormaÃÃo Santana, efetuando pesquisas que venham a contribuir efetivamente para o melhor entendimento da himenopterofauna da Bacia do Araripe e enriquecendo os acervos brasileiros com seus fÃsseis.
This thesis describes new specimens of Hymenoptera from the laminated limestone of Crato Member (Aptian), Santana Formation, Araripe Basin that outcrops at Nova Olinda district, south of the Cearà State, Brazil. It also summarizes the occurrences of fossil Hymenoptera, mainly the Early Cretaceous fauna. The study of ten specimens of Hymenoptera Apocrita described here revealed the occurrence of three families: Sphecidae (Cretosphex magnus Darling 1990 and C. parvus Darling 1990), Sapygidae (Cretofedtschenkia santanensis Osten 2007), and Evaniidae, this latter represented by a new genus and a new species. In the Araripe Basin, suborder Symphyta is unusual, and Apocrita are more diverse, with Parasitica forms (Ichneumonoidea, âEphialtitidae, Proctotrupidae, and âMesoserphidae), and Aculeata species of Sphecidae (the most abundant), Rhopalosomatidae, Sapygidae, Scoliidae, Tiphiidae, Vespidae, and possibly Formicidae. Throughout its geological history, Hymenoptera are mainly represented by wasps. They are relatively common at Jurassic time, showing a long period of great diversification (from Late Jurassic to Tertiary), when rose more than 80% of all 107 families with fossil records. The extinction that affected the organisms at the Cretaceous end seems to have also affected Hymenoptera, which show the largest number of families extinct in its history. Hymenoptera from the Crato Member are preserved by mineral substitution, articulated, with open wings, and extended legs, showing major number of female, without known larvae. It is a distinct fauna from the main known Early Cretaceous himenopterofaunas (Spain, Australia, Mongolia and Siberia), not sharing any genre, but having in common the small participation of Symphyta. The history of Cretaceous Hymenoptera research in Brazil shows that the greatest number and the most significant papers have been accomplished by foreign researchers, so the most of Hymenoptera specimens from the Crato Member of the Araripe Basin is out of Brazil. It is therefore necessary that the Brazilian researchers take the study of this order of insects that occur in the Santana Formation, performing studies which will effectively contribute to the better understanding of the himenopterofauna of the Araripe Basin and enriching the Brazilian collections with their fossils.
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Carbonari, Vander. "COMPOSIÇÃO FAUNÍSTICA DE VESPAS (HYMENOPTERA: APOCRITA) DO PARQUE NACIONAL DA SERRA DA BODOQUENA." UNIVERSIDADE FEDERAL DA GRANDE DOURADOS, 2009. http://tede.ufgd.edu.br:8080/tede/handle/tede/282.
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Previous issue date: 2009-05-26This work aims at performing the inventory of predator and parasitic wasps fauna in different forest formations of Bodoquena Range Mountain National Park (PNSB). The collections were made in the municipalities of Bodoquena, Bonito, Jardim and Porto Murtinho, covering the two parts (North and South) of PNSB, within a discontinuous period of 35 days of collecting, between february/2007 to december/2008. Seven expeditions were undertaken in the field, seven days each, in areas with predominance of deciduous and semideciduous seasonal forest. The data collection techniques employed in faunal inventory were active collection with entomological net, Malaise traps, yellow pads and mini-Winkler extractors. Three-hundred fifty one specimens Aculeata group, represented by 105 species in 57 genera, distributed in the following families: Vespidae, Pompilidae, Mutillidae; Tiphiidae; Scoliidae. The total number of individuals of the Hymenoptera Parasitica series in Bodoquena Mountain Range was 1243, following the percentage: Ichneumonoidea: Ichneumonidae (16%); Braconidae (9%); Platygastroidea: Scelionidae (18%), Platygastridae (1%); Proctotrupoidea: Diapriidae (11%), Chrysidoidea: Bethylidae (14%), Dryinidae (2%), Chrysididae (1%); Ceraphronoidea:Ceraphronidae (4%), Megaspilidae (1%); Evanioidea: Evaniidae (2%); Trigonalioidea: Trigonalidae (1%); and the superfamilies Chalcidoidea (19%) and Cynipoidea (1%). It was not possible to identify the families yet, for these two superfamilies, and all families of Parasitica were not possible to identify at the genera level. Some groups were sampled by one of the techniques employed, showing that the use of various techniques is essential to surveying wasps. The results of this study contribute to the knowledge of the richness of the wasps fauna and their geographical distribution and provide subsidies for insects fauna conservation in these forests
Este trabalho tem como objetivo inventariar a fauna de vespas predadoras e parasíticas nas diferentes formações florestais do Parque Nacional da Serra da Bodoquena (PNSB). As coletas foram realizadas nos municípios de Bodoquena, Bonito, Jardim e Porto Murtinho, cobrindo as duas porções (Norte e Sul) do PNSB, em um período descontínuo de 35 dias de amostragens, entre fevereiro/2007 a dezembro/2008. Foram realizadas sete expedições de campo, de sete dias cada, em áreas com predomínio de Floresta Estacional Decidual e Semidecidual. As técnicas de coleta empregadas no inventário faunístico foram: coleta ativa com rede entomológica, armadilhas de Malaise, bandejas amarelas e extratores de mini-Winkler. Foram capturados 351 exemplares do grupo Aculeata representados por 105 espécies em 57 gêneros, distribuídos nas seguintes famílias: Vespidae, Pompilidae, Mutillidae; Tiphiidae; Scoliidae. O número total de exemplares de Hymenoptera da série Parasitica na Serra da Bodoquena foi 1.243, sendo a porcentagem: Ichneumonoidea:Ichneumonidae (16%), Braconidae (9%); Platygastroidea: Scelionidae (18%), Platygastridae (1%); Proctotrupoidea: Diapriidae (11%); Chrysidoidea: Bethylidae (14%), Dryinidae (2%), Chrysididae (1%); Ceraphronoidea; Ceraphronidae (4%), Megaspilidae (1%); Evanioidea: Evaniidae (2%) Trigonalioidea: Trigonalidae (1%); e as superfamílias Chalcidoidea (19%) e Cynipoidea (1%), para estas duas superfamílias ainda não foi possível a identificação das famílias, e para todas as famílias de parasítica não foi possível a identificação dos gêneros. Alguns grupos foram amostrados por apenas uma das técnicas empregadas, mostrando que a utilização de técnicas variadas é fundamental para se fazer inventários faunísticos de vespas. Os resultados obtidos neste estudo contribuem para o conhecimento da riqueza da fauna de vespas e sua distribuição geográfica e fornece subsídios para a conservação da entomofauna dessas florestas
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Carvalho, Gabriela Karine Rocha de. "Alguns himenóptera Apocrita do Membro Crato (Aptiano) da Formação Santana, Bacia do Araripe." reponame:Repositório Institucional da UFC, 2012. http://www.repositorio.ufc.br/handle/riufc/22852.
Повний текст джерелаАнотація:
CARVALHO, Gabriela Karine Rocha de. Alguns himenóptera Apocrita do Membro Crato (Aptiano) da Formação Santana, Bacia do Araripe. 2012. 73 f. Dissertação (Mestrado em Geologia)-Universidade Federal do Ceará, Fortaleza, 2012.Submitted by Jairo Viana (jairo@ufc.br) on 2017-05-24T21:00:28Z No. of bitstreams: 1 2012_dis_gkrcarvalho.pdf: 4582791 bytes, checksum: 34159a1f2e9a3591c61a972431f84653 (MD5)
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This thesis describes new specimens of Hymenoptera from the laminated limestone of Crato Member (Aptian), Santana Formation, Araripe Basin that outcrops at Nova Olinda district, south of the Ceará State, Brazil. It also summarizes the occurrences of fossil Hymenoptera, mainly the Early Cretaceous fauna. The study of ten specimens of Hymenoptera Apocrita described here revealed the occurrence of three families: Sphecidae (Cretosphex magnus Darling 1990 and C. parvus Darling 1990), Sapygidae (Cretofedtschenkia santanensis Osten 2007), and Evaniidae, this latter represented by a new genus and a new species. In the Araripe Basin, suborder Symphyta is unusual, and Apocrita are more diverse, with Parasitica forms (Ichneumonoidea, †Ephialtitidae, Proctotrupidae, and †Mesoserphidae), and Aculeata species of Sphecidae (the most abundant), Rhopalosomatidae, Sapygidae, Scoliidae, Tiphiidae, Vespidae, and possibly Formicidae. Throughout its geological history, Hymenoptera are mainly represented by wasps. They are relatively common at Jurassic time, showing a long period of great diversification (from Late Jurassic to Tertiary), when rose more than 80% of all 107 families with fossil records. The extinction that affected the organisms at the Cretaceous end seems to have also affected Hymenoptera, which show the largest number of families extinct in its history. Hymenoptera from the Crato Member are preserved by mineral substitution, articulated, with open wings, and extended legs, showing major number of female, without known larvae. It is a distinct fauna from the main known Early Cretaceous himenopterofaunas (Spain, Australia, Mongolia and Siberia), not sharing any genre, but having in common the small participation of Symphyta. The history of Cretaceous Hymenoptera research in Brazil shows that the greatest number and the most significant papers have been accomplished by foreign researchers, so the most of Hymenoptera specimens from the Crato Member of the Araripe Basin is out of Brazil. It is therefore necessary that the Brazilian researchers take the study of this order of insects that occur in the Santana Formation, performing studies which will effectively contribute to the better understanding of the himenopterofauna of the Araripe Basin and enriching the Brazilian collections with their fossils.
O presente trabalho descreve novos espécimes de himenópteros provenientes dos calcários laminados do Membro Crato (Aptiano) da Formação Santana, Bacia do Araripe, aflorantes no município de Nova Olinda, sul do Estado do Ceará. Também sumaria as diversas ocorrências de himenópteros fósseis, destacando as eocretáceas. O estudo de dez exemplares de Hymenoptera Apocrita aqui descritos revelou a ocorrência de três famílias: Sphecidae (Cretosphex magnus Darling 1990 e C. parvus Darling 1990), Sapygidae (Cretofedtschenkia santanensis Osten 2007) e Evaniidae, esta representada por um gênero e espécie novos. Na Bacia do Araripe, a subordem Symphyta é pouco comum, e os Apocrita são mais diversificados, com os Parasitica reunindo formas de Ichneumonoidea, †Ephialtitidae, Proctotrupidae, †Mesoserphidae e Evaniidae, e os Aculeata com espécies de Sphecidae (os mais abundantes), Sapygidae, Rhopalosomatidae, Scoliidae, Tiphiidae, Vespidae e possivelmente Formicidae. Ao longo de sua história geológica, os himenópteros são principalmente representados por vespas. A partir do Jurássico são insetos relativamente comuns, apresentando um longo período de grande diversificação (do Neojurássico ao Terciário), quando surgiram mais de 80% de todas as 107 famílias com registro fóssil atualmente conhecidas. A extinção que afetou os organismos de modo geral ao final do Cretáceo parece também ter afetado os himenópteros, que mostram o maior número de famílias extintas por período geológico de sua história. Os himenópteros do Membro Crato estão preservados por substituição mineral, articulados, com asas abertas e pernas extendidas, mostrando maior número de espécimes fêmeos do que machos, sem larvas conhecidas. É uma fauna bastante distinta das principais himenopterofaunas eocretáceas conhecidas (Espanha, Mongólia, Austrália e Sibéria), não compartilhando nenhum gênero, mas tendo como característica em comum a pequena participação dos Symphyta. A história da pesquisa dos himenópteros cretáceos no Brasil mostra que a maioria e os mais significativos trabalhos têm sido efetuados por pesquisadores estrangeiros, de modo que a maior parte dos exemplares de Hymenoptera provenientes do Membro Crato da Bacia da Araripe encontra-se atualmente fora do Brasil, tornando-se necessário que os paleontólogos brasileiros assumam o estudo desta ordem de insetos ocorrente na Formação Santana, efetuando pesquisas que venham a contribuir efetivamente para o melhor entendimento da himenopterofauna da Bacia do Araripe e enriquecendo os acervos brasileiros com seus fósseis.
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LANES, G. O. "Atlas anatômico de Bethylidae (Hymenopetera, Chrysidoidea): Diversidade de estruturas e termos dos caracteres fenotípicos." Universidade Federal do Espírito Santo, 2013. http://repositorio.ufes.br/handle/10/4358.
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Previous issue date: 2013-02-27O exoesqueleto e a musculatura da família de vespas parasitóides Bethylidae é revisado. Termos utilizados para outros grupos de Hymenoptera são revisados, e uma terminologia consensual é proposta. Caracteres externos são redescritos e correlacionados aos apódemas e músculos correspondentes; sua importância filogenética é discutida. 456 estruturas esqueléticas foram denominadas e definidas, das quais 133 são propostas ou redefinidas. 69 músculos são examinados e foram propostas homologias com aqueles presentes em outras famílias de Hymenoptera.
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Krogmann, Lars. "Molekulargenetische und morphologische Untersuchungen zur systematischen Stellung der Pteromalidae innerhalb der Chalcidoidea (Hymenoptera: Apocrita)." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=97676945X.
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Barritault, Marc. "Etude du rôle du récepteur des androgènes dans le cancer du sein apocrine moléculaire." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC300/document.
Повний текст джерелаАнотація:
Les cancers du sein hormono-indépendants et HER2 non amplifiés, dites triples négatives (TN), représentent 30 % des tumeurs du sein. Elles sont de mauvais pronostic et ne bénéficient pas actuellement de thérapeutiques ciblées.Les tumeurs du sein apocrine moléculaire (AM) sont des tumeurs qui se caractérisent par l’absence de récepteurs hormonaux et la présence du récepteur aux androgènes (RA) dont la voie de signalisation est activée. Dans 50 % des cas elles sont HER2 négatives, et entrent alors dans la catégorie des TN.Le rôle de cette signalisation androgénique est mal connu. Cependant elle apparait comme une cible thérapeutique intéressante dans ce groupe de tumeur ne bénéficiant pas des thérapies ciblées. De plus peu de modèles précliniques représentatifs des tumeurs AM ont été publiés.Dans ce projet nous avons exploré le RA et sa signalisation à partir de modèles de lignées cellulaires.Nous avons d’abord caractérisé ces modèles sur le plan mutationnel en séquençant le RA et en recherchant des altérations moléculaires dans les voies de signalisation des récepteurs hormonaux et des facteurs de croissance puis sur le plan transcritpomique en vérifiant la présence d’une signature AM moléculaire et en recherchant des variants d’épissage du RA.Nous avons ensuite pu mettre en évidence une régulation de la prolifération et de la clonogénicité de ces lignées après blocage du RA et de sa voie de signalisation par invalidation de son expression par siRNA.Nous avons finalement pu vérifier dans plusieurs de ces modèles qu’un traitement par différents agonistes et antagonistes ciblant le RA permettait de moduler la prolifération et l’expression des gènes cibles du RAHormone-independent and non-amplified HER2 breast cancers, or triple negative (TN), represent 30% of breast tumors. They have a poor prognosis and do not currently benefit from targeted therapies.Molecular apocrine (MA) breast cancers are characterized by the absence of hormone receptors and the presence of the androgen receptor (AR) which signaling pathway is activated. In 50% of cases they are HER2 negative, and then fall into the category of TN.The role of the androgen signaling is poorly understood. However the AR appears as an attractive therapeutic target in this group of tumors without targeted therapies. Moreover few preclinical models of MA have been published.In this project we explored the AR and its signaling in cell lines models.We first characterized these models on the mutational level by sequencing the AR and seeking molecular alterations in the signaling pathways of hormone receptors and growth factors. Then on the transcritpomique level by checking the presence of a molecular MA signature and seeking the AR splice variants.We then could highlight a regulation of cell proliferation and clonogenicity in these cell lines by blocking the AR and its signaling pathway with siRNAs.We were finally able to check in several of these models that treatment with different agonists and antagonists targeting the AR allowed to modulate cell proliferation and the expression of AR target genes
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Selim, Abdel-Ghani Abdel-Zaher El-Sayed. "Receptor status and genetic changes in apocrine metaplasia and their possible role in breast oncogenesis." Thesis, Queen Mary, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313026.
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Flórez, Andrés Fabián Herrera. "Considerações taxonômicas sobre os Banchinae e revisão das espécies brasileiras de Glyptini (Hymenoptera: Ichneumonidae)." Universidade Federal de São Carlos, 2010. https://repositorio.ufscar.br/handle/ufscar/2000.
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Previous issue date: 2010-06-07Universidade Federal de Sao Carlos
The Banchinae is a cosmopolitan group of Ichneumonidae comprising three tribes: Atrophini, Banchini and Glyptini; it includes about 50 genera and 1500 described species. The Banchinae generally have long, apically notched ovipositor, a propodeum without or with only a few carinae, and frequently, a tergite I with spiracles located around or before the centre, and the anterior part of the submetapleural carina expanded into a broad lobe. This work is a taxonomic revision of the subfamily Banchinae with emphasis in the tribe Glyptini from Brazil. This tribe is characterized by the possession of oblique grooves on tergites II-IV. This study is based on the main entomological collections of South and Southeastern Brazil; in total more than 3.000 specimens of the subfamily have been examined, not including all of genera already registered to Brazil. Material from 17 of the 27 States of Brazil has been reviewed, although most of the specimens (70.3%) were collected in São Paulo State. The subfamily Banchinae has been registered so far in four kind of Brazilian biomes: Atlantic Forest, Brazilian Savanna, Amazonia and agroecosystems, between 2 and 2.039 m of altitude. The study has revealed the presence in Brazil of 17 genera of Banchinae, one of them is a new genus; 18 new species of the tribe Glyptini are described. Illustrated keys are given to enable the identification of the tribes and the genera of the subfamily Banchinae and the species of the tribe Glyptini from Brazil.
Banchinae é uma subfamília cosmopolita de Ichneumonidae composta por três tribos: Atrophini, Banchini e Glyptini, inclui cerca de 50 gêneros e cerca de 1500 espécies descritas. Os Banchinae geralmente possuem ovipositor longo entalhado no ápice, propodeo sem ou com poucas carenas e freqüentemente, tergito I com espiráculos localizados próximos ao centro ou antes do mesmo, e parte anterior da carena submetapleural dilatada num lobo largo. Este trabalho é uma revisão taxonômica da subfamília Banchinae com ênfase nas espécies brasileiras da tribo Glyptini. Esta tribo é caracterizada pela presença de ranhuras oblíquas sobre os tergitos II-IV. Este estudo baseia-se nas principais coleções entomológicas do Sul e Sudeste do Brasil. No total mais de 3.000 exemplares da subfamília foram examinados, não incluindo todos os gêneros já registrados para o Brasil. Material de 17 dos 27 estados do Brasil foi revisado, embora a maioria dos espécimes (70,3%) tenha sido coletada no Estado de São Paulo. A subfamília Banchinae foi registrada até o momento em quatro tipos de biomas brasileiros: Mata Atlântica, Cerrado, Amazônia e agroecossistemas, entre os dois e 2.039 m de altitude. O estudo revelou a presença no Brasil de 17 gêneros de Banchinae, um deles um novo para a ciência; 18 novas espécies da tribo Glyptini são descritas. Chaves ilustradas são apresentadas para permitir a identificação das tribos e gêneros da subfamília Banchinae e as espécies da tribo Glyptini do Brasil.
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Feijter, Anja de. "Apocrief, de analphabetische naam : het historisch debuut van Lucebert in het licht van de intertekst van Joodse mystiek en Hölderlin /." Amsterdam : Uitg. de Bezige bij, 1994. http://catalogue.bnf.fr/ark:/12148/cb37471606f.
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Bruxelles, Marie-Christine. "La maladie de Paget extra-mammaire : à propos de dix observations cliniques." Bordeaux 2, 1992. http://www.theses.fr/1992BOR2M191.
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Brito, Pedro Vale de Azevedo 1982. "Morfologia dos espermatozoides de Melittobia hawaiiensis, Perkins, M. australica, Girault (Chalcidoidea: Eulophidae) e Neochrysis lecointei, Ducke (Chrysidoidea: Chrysididea), com considerações filogeneticas em apocrita (Hymenoptera)." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317859.
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Orientadores: Mary Anne Heidi Dolder, Jose Lino NetoDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: Hymenoptera é uma das maiores ordens de inseto no mundo e nenhum outro grupo possui tantas espécies benéficas para o homem quanto esse. A morfologia dos espermatozóides tem provado ser capaz de fornecer dados úteis para estudos filogenéticos em diversos grupos de insetos, inclusive os Hymenoptera. Porém, os estudos existentes até o momento descrevendo a morfologia dos espermatozóides nessa ordem ainda não são suficientes para permitir inferências filogenéticas mais abrangentes. Neste trabalho descrevemos a morfologia dos espermatozóides de Melittobia hawaiiensis e M. australica (Chalcidoidea) e de Neochrysis lecointei (Chrysidoidea) resultando em dois manuscritos que estão em fase de submissão. Comparando os dados desse estudo com os disponíveis na literatura observamos que algumas características como a presença de estruturas espiraladas nos espermatozóides, presença de material extracelular associado ao ápice dos espermatozóides e a ordem de desorganização dos microtúbulos do axonema no final do flagelo, parecem fornecer informações possíveis de serem utilizadas na filogenia das superfamílias de Hymenoptera. Outras características, como a morfologia do adjunto do centríolo e dos derivados mitocôndrias, parecem ser capazes de fornecer informações que indicam as relações de parentesco entre táxons inferiores, inclusive gêneros (ou tribos) da mesma família
Abstract: Hymenoptera is one of the largest insect orders in the world and no other group presents so many benefic species for humanity. In spite of these insects¿ importance, there are still many uncertainties about this group¿s phylogeny. Spermatozoa morphology has proved useful in resolving phylogenetic questions in many insects¿ orders, including Hymenoptera, although the available studies describing sperm morphology in this order do not include enough taxa to allow detailed phylogenetic studies. This study describes the sperm morphology of Melittobia hawaiiensis and M. australica (Chalcidoidea) and of Neochrysis lecointei (Chrysidoidea), which resulted in two manuscripts to be submitted for publication. Comparing data obtained in this study with those available in the literature there are some characteristics such as the presence of spiraling structures in spermatozoa, the extracellular material coating spermatozoa apex and the order of disorganization of the axoneme microtubules at the flagellum end that could be used to provide information about the Hymenoptera superfamilies¿ phylogeny. Other characteristics, such as the centriolar adjunct and mitochondrial derivatives¿ morphology, provide information about the relationships among inferior taxons, including those of the same genera, or tribes of the same family
Mestrado
Biologia Celular
Mestre em Biologia Celular e Estrutural
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Urie, Birdget K. "Evaluation of Expression and Function of VEGFR2, PDGFRα, PDGFRβ, KIT, and RET in Canine Apocrine Gland of the Anal Sac Adenocarcinoma and Thyroid Carcinoma". The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337702663.
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Fischer, Torkel. "Boplatsval hos solitära getingar, bin och rovsteklar." Thesis, Mälardalen University, Mälardalen University, Mälardalen University, Mälardalen University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-5433.
Повний текст джерелаАнотація:
Denna undersökning gjordes för att studera solitära steklars boplatsval speciellt med avseende på spatiala mönster. Aggregat av lämpliga bohål (bibatterier) tillverkades och gjordes tillgängliga förfrilevande steklar. Resultatet visade att steklar tenderar att anlägga bon i närheten av andra stekelbon. Ingen tendens fanns att anlägga bon i centralt belägna positioner. Steklarna verkar också föredra att anlägga bon till vänster om en tänkt mittllinje på bibatterierna. Aggregation kan vara ett sätt att undgå parasitering och predation vid boplatsen. Om detta orsakade aggregationstendensen var det dock något oväntat att inte också en central tendens kunde påvisas. Att steklarna föredrog bohål i bibatteriernas vänstra del är svårt att förklara.
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Fagan, Erin A. "Identification of the presence and activity of the JAK-STAT pathway in canine solid tumors." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/100859.
Повний текст джерелаАнотація:
Background: The JAK-STAT pathway is a cellular signaling pathway, which acts normally in humans and animals in the control of multiple important functions. Dysregulation of this pathway has been identified in human cancers, as well as a limited number of veterinary cancers.
Objectives: The aims of this study were to identify the presence and tentative activity of components of the JAK-STAT pathway in selected canine tumors.
Methods: Formalin-fixed, paraffin-embedded samples from mast cell tumors (MCT), hemangiosarcomas (HSA), thyroid carcinomas, and apocrine gland anal sac adenocarcinomas (AGASACA) were obtained from the Diagnostic Histopathology Laboratory at the Virginia Maryland College of Veterinary Medicine. Immunohistochemistry was performed to evaluate protein levels of JAK1, phospho-JAK1, JAK2, phospho-JAK2, STAT3, and phospho-STAT3. Signalment, treatment information, and survival information was obtained from the medical record for each case.
Results: Tumor samples were scored for percent positive neoplastic cells. Positive staining was seen for all antibodies in all tumor types, with expression of JAK1, STAT3, and pSTAT3 being highest overall for all tumor types. Significant associations were seen between JAK1 and survival time in MCT (p = 0.03), pJAK1 and survival time in HSA (p = 0.009) and MCT (p = 0.04), and pSTAT3 and metastasis in MCT (p = 0.0008).
Conclusions: The finding of positive staining for the components of the JAK-STAT pathway in the tumor samples evaluated indicates presence and tentative activity of this pathway in the studied cancers. Further study of JAK1, pJAK1, and pSTAT3 should be pursued to evaluate their potential as therapeutic targets.MS
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Coussy, Florence. "Identification de nouvelles thérapeutiques ciblées dans le cancer du sein à l’aide d’un large panel de tumeurs humaines xénogreffées." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS560.
Повний текст джерелаАнотація:
Le cancer du sein triple négatif (CSTN) représente 10-15% des cancers du sein. Son pronostic est sombre en particulier face à la rareté des thérapies ciblées adaptées à ce sous type. Sa complexité de prise en charge est directement liée à sa grande hétérogénéité tant au niveau moléculaire que morphologique.Dans ce contexte, nous avons développés des modèles de Patient Derived Xenograft (PDX) issus de CSTN. Ce modèle, robuste, a la particularité de retenir les caractéristiques (histologiques, génotypiques mais aussi phénotypiques) des tumeurs observées chez les patients.Dans notre cohorte de 61 PDX de CSTN, nous avons confirmé l’hétérogénéité anatomopathologique et génomique de ce sous type. Les différentes anomalies moléculaires mises en évidence sont de faible fréquence (<10%) mais 88% de nos modèles ont une altération potentiellement ciblables et plus de la moitié ont au moins 2 altérations ciblables. Nous nous sommes particulièrement intéressés à 2 sous types de CSTN : (i) le sous -type LAR (Luminal Androgen Receptor) dont nous avons décrit les premiers modèles de PDX : ces modèles présentent des altérations fréquentes de la voie PI3K ainsi que des réponses majeures aux inhibiteurs de cette voie ; (ii) le sous type métaplasique, dont 4 de nos 9 modèles présentent une double altération genomique dans les voies PI3K et RTK-MAPK ainsi que des réponses complètes et durables à la combinaison d’inhibiteurs de PI3K et de MAPK.Dans les autres sous-types de CSTN, nous avons également mis en évidence des taux de réponse importants aux inhibiteurs de la voie PI3K et MAPK. Les biomarqueurs de réponse à ces différentes thérapies ciblées testées sont en cours d’étude en particulier par intégration des données génomique et protéique de nos modèlesTriple negative breast cancer (TNBC) accounts for 10-15% of breast cancers. Its prognosis is worse, particularly due to the rarity of targeted therapies adapted to this subtype. Its complexity of management is directly related to its high heterogeneity, both at the morphological and genomical levels.In this context, we developed Patient Derived Xenograft (PDX) models from TNBC. This robust model has the specificity of retaining the characteristics (histological, genotypic but also phenotypic) of the tumors observed in patients.In our cohort of 61 PDXs of TNBC, we confirmed the anatomopathological and genomical heterogeneity of this subtype. Majority of targeted alterations are of low frequency (<10%) but 88% of our models harbour a potential targetable alteration and more than half have at least 2 targetable alterations. We were particularly interested in 2 subtypes of TNBC: (i) the LAR subtype for which we have described the first PDX models: these models present frequent alterations of the PI3K pathway as well as major responses to PI3K inhibitors; (ii) the metaplastic subtype, of which 4 of our 9 models show double alterations in the PI3K and RTK-MAPK pathways and complete and durable responses to the combination of PI3K-MAPK inhibitors.In the other CSTN subtypes, we have also demonstrated significant response rates to PI3K and MAPK inhibitors. Biomarkers of response to these various targeted therapies tested are being studied, in particular by integrating the genomic and protein data from a higher number of PDX models
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Isidoro, Joana Margarida Beirão. "Diagnóstico laboratorial em animais de companhia." Master's thesis, Universidade de Évora, 2018. http://hdl.handle.net/10174/23814.
Повний текст джерелаАнотація:
O presente relatório visa a descrição das atividades desenvolvidas ao longo do estágio curricular no âmbito do diagnóstico laboratorial em animais de companhia, realizado no Hospital Veterinário de Portimão. O mesmo encontra-se dividido em três partes principais: a primeira expõe a casuística observada durante o estágio, sendo apresentada uma descrição estatística dos procedimentos acompanhados e realizados pela autora. A segunda parte abrange uma revisão bibliográfica subordinada ao tema exame citológico no diagnóstico de neoplasias: aplicação em dermatologia oncológica. A terceira parte, apresenta o relato e discussão de um estudo de caso sobre cistoadenoma das glândulas apócrinas observado num paciente canino durante o período de estágio. A análise citológica em Medicina Veterinária tem mostrado ser um dos mais preciosos auxiliares de diagnóstico oncológico na prática clínica de animais de companhia. Porém, o recurso a outras técnicas coadjuvantes, frequentemente, revela-se crucial para a obtenção de um diagnóstico definitivo; Abstract: Laboratory diagnosis in companion animals
This report aims to describe the activities carried out during the traineeship in the scope of laboratory diagnosis in companion animals which took place at Hospital Veterinário de Portimão. The report is divided in three main parts: the first one adresses the casuistry observed during the traineeship, presenting a statistical description of the procedures followed and performed by the author. The second part concerns a bibliographical review subordinated to the theme cytological exam in the diagnosis of neoplasias: application in oncological dermatology. The third part is the report and discussion of a case study on apocrine gland cystadenoma, observed in a canine patient during the internship period.
Cytological analysis in Veterinary Medicine has shown to be one of the most valuable oncological diagnosis aids in the clinical practice of companion animals. However, the use of other coadjuvant techniques often proves to be crucial for a definitive diagnosis.
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Grellety, Thomas. "Contribution à l’étude des mécanismes de sensibilité aux traitements antiandrogènes dans les cancers du sein moléculaires apocrines." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0088/document.
Повний текст джерелаАнотація:
Les cancers moléculaires apocrines sont un sous-groupe de cancer du sein caractérisé par l'expression du récepteur aux androgènes (RA), l'absence du récepteur aux oestrogènes (RE) et l'expression paradoxale de nombreux gènes typiquement exprimés dans les tumeurs RE positives. Une proportion significative de ces patientes va récidiver sous forme de métastases dont la prise en charge repose sur des traitements non spécifiques (chimiothérapies). En préclinique, la lignée cellulaire MDA-MB-453 a été identifiée comme ayant un profil transcriptomique similaire à ce sous-groupe tumoral. En clinique, les essais réalisés dans ce sousgroupe tumoral avec différents anti-androgènes, dont l’abiratérone (inhibiteur de la synthèse des androgènes), retrouvent un bénéfice clinique chez environ 25% des patientes. L’objectif de cette thèse est d’améliorer les connaissances et les prises en charge thérapeutiques spécifiques de ces tumeurs. Nos données précliniques comparatives montrent que l'ODM-201, nouvel antiandrogène, ne présente pas une efficacité supérieure par rapport aux antiandrogènes déjà étudiés. Afin de contourner les limites des lignées cellulaires identifiées dans ce premier projet, nous avons démontré la nécessité de développer de nouveaux modèles : les Patient-Derived-Xenograft orthotopiques. Notre deuxième projet est en faveur d’une meilleure sélection des patientes à traiter par abiratérone notamment basé sur des caractéristiques immunohistochimiques apocrines. Chez les patientes ne présentant pas ces caractéristiques, nous avons isolé CHEK1 comme une cible d’intérêt en combinaison thérapeutique pour majorer les taux de réponse de l’abiratérone en monothérapieMolecular apocrine cancers are a subgroup of breast cancer characterized by the expression of the androgen receptor (AR), the absence of the estrogen receptor (ER) and the paradoxical expression of many genes typically expressed in ER positive tumors. A significant proportion of these patients will recur in the form of metastases whose management is based on non-specific treatments (chemotherapy). In preclinical study, the MDA-MB-453 cell line was identified as having a transcriptomic profile similar to this tumor subgroup. Clinical trials in this tumor subgroup testing different antiandrogens, including abiraterone (inhibitor of androgen synthesis), found a clinical benefit in about 25% of patients. The aim of this thesis is to improve the knowledge and the specific therapeutic management of these tumors. Our comparative preclinical data show that ODM-201, a new anti-androgen, does not show superior efficacy compared to previously studied anti-androgens. In order to circumvent the limits of cell lines provided by this first project, we have shown the need to develop new models: orthotopic Patient-Derived-Xenograft. Our second project favors a better selection of patients to be treated with abiraterone, especially based on apocrine immunohistochemical characteristics. In patients without these characteristics, we isolated CHEK1 as a target of interest in combination therapy to increase response rates of abiraterone monotherapy
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Krogmann, Lars [Verfasser]. "Molekulargenetische und morphologische Untersuchungen zur systematischen Stellung der Pteromalidae innerhalb der Chalcidoidea (Hymenoptera: Apocrita) / vorgelegt von Lars Krogmann." 2005. http://d-nb.info/97676945X/34.
Повний текст джерела
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Freire, Madalena Nogueira Dias. "Adenocarcinoma das glândulas apócrinas dos sacos anais em cães." Master's thesis, 2018. http://hdl.handle.net/10437/8768.
Повний текст джерелаАнотація:
Orientação: Joana de
Oliveira ; co-orientação: Ana Rita SerrasO adenocarcinoma das glândulas apócrinas dos sacos anais em cães é uma neoplasia de carácter maligno, com taxas de metastização de 36 até 96%. O objectivo deste estudo foi comparar os métodos de condução de casos de adenocarcinoma das glândulas apócrinas dos sacos anais num hospital de referência, em cirurgia de tecidos moles, no Reino Unido, com a metodologia descrita na literatura de evidência médica atual. O presente estudo incluiu a documentação de 4 casos de cães presentes à consulta de especialidade cirúrgica com queixa compatível com adenocarcinoma das glândulas apócrinas dos sacos anais no hospital veterinário Rosemary Lodge. Dois dos pacientes eram da raça Labrador Retriever, que pode ter sido devido à popularidade da raça em Inglaterra. A maioria dos sinais clínicos não eram específicos nem sistémicos, no entanto todos os pacientes apresentaram hipercalcémia nas análises clínicas, o que está descrito como um síndrome paraneoplásico neste tipo de tumor. Neste estudo constatou-se que os casos de AGASA foram conduzidos apenas com uma abordagem cirúrgica, não tendo sido submetidos a tratamento adjuvante segundo as guidelines recomendadas pelos especialistas em Oncologia. Conclui-se que é necessário consciencializar a comunidade veterinária, de forma a que os casos oncológicos sejam uniformemente referenciados para tratamentos adjuvantes ou coadjuvantes como descritos na literatura médica.
Apocrine gland anal sac adenocarcinoma (AGASAC) in dogs is a malignant neoplasm with metastatic rates described from 36 to 96%. The goal of this study was to compare the approach on cases of apocrine glands of the anal sac adenocarcinoma from a Soft Tissue Referral hospital, in the United Kingdom, with the approach described in the evidence-based literature. The present study consisted on the description of 4 canine clinical cases that were presented to a Soft Tissue Surgery referral consultation at the Veterinary Hospital Rosemary Lodge with a complaint compatible with apocrine glands anal sac adenocarcinoma. Two pacients were of the Labrador Retriever breed, which may have been due to the breed popularity in United Kingdom. Clinical signs were often nonspecific nor systemic, although all the pacients presented hypercalcemia in the blood work, which has been described as a paraneoplasic syndrome in this type of tumour. In this study, it was found that the cases of AGASAC were conducted on a surgical approach only, and didn´t receive adjuvant treatment following the current oncology guidelines. Is has been sugested that it is necessary to increase awareness, so that oncology cases should be referred for adjuvant treatments as described in medical literature.