Добірка наукової літератури з теми "AP-4 Complex"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "AP-4 Complex".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Статті в журналах з теми "AP-4 Complex"
Hirst, Jennifer, Nicholas A. Bright, Brian Rous, and Margaret S. Robinson. "Characterization of a Fourth Adaptor-related Protein Complex." Molecular Biology of the Cell 10, no. 8 (August 1999): 2787–802. http://dx.doi.org/10.1091/mbc.10.8.2787.
Повний текст джерелаSalazar, G., B. Craige, M. L. Styers, K. A. Newell-Litwa, M. M. Doucette, B. H. Wainer, J. M. Falcon-Perez, et al. "BLOC-1 Complex Deficiency Alters the Targeting of Adaptor Protein Complex-3 Cargoes." Molecular Biology of the Cell 17, no. 9 (September 2006): 4014–26. http://dx.doi.org/10.1091/mbc.e06-02-0103.
Повний текст джерелаDell’Angelica, Esteban C., Chris Mullins, and Juan S. Bonifacino. "AP-4, a Novel Protein Complex Related to Clathrin Adaptors." Journal of Biological Chemistry 274, no. 11 (March 12, 1999): 7278–85. http://dx.doi.org/10.1074/jbc.274.11.7278.
Повний текст джерелаPonsankarar, Lalitha, A. Sinthiya, and V. Rashmi. "Hydrogen-bonding interaction of 4-AP metal complex with proteins." Acta Crystallographica Section A Foundations and Advances 73, a2 (December 1, 2017): C402. http://dx.doi.org/10.1107/s2053273317091719.
Повний текст джерелаBehne, Robert, Julian Teinert, Miriam Wimmer, Angelica D’Amore, Alexandra K. Davies, Joseph M. Scarrott, Kathrin Eberhardt, et al. "Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking." Human Molecular Genetics 29, no. 2 (January 9, 2020): 320–34. http://dx.doi.org/10.1093/hmg/ddz310.
Повний текст джерелаBAROIS, Nicolas, and Oddmund BAKKE. "The adaptor protein AP-4 as a component of the clathrin coat machinery: a morphological study." Biochemical Journal 385, no. 2 (January 7, 2005): 503–10. http://dx.doi.org/10.1042/bj20041010.
Повний текст джерелаMattera, Rafael, Chad D. Williamson, Xuefeng Ren, and Juan S. Bonifacino. "The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A." Molecular Biology of the Cell 31, no. 9 (April 15, 2020): 963–79. http://dx.doi.org/10.1091/mbc.e19-11-0658.
Повний текст джерелаSchneider, Helga, Margarita Martin, Fernando A. Agarraberes, Li Yin, Iris Rapoport, Tomas Kirchhausen та Christopher E. Rudd. "Cytolytic T Lymphocyte-Associated Antigen-4 and the TCRζ/CD3 Complex, But Not CD28, Interact with Clathrin Adaptor Complexes AP-1 and AP-2". Journal of Immunology 163, № 4 (15 серпня 1999): 1868–79. http://dx.doi.org/10.4049/jimmunol.163.4.1868.
Повний текст джерелаMattera, Rafael, Sang Yoon Park, Raffaella De Pace, Carlos M. Guardia, and Juan S. Bonifacino. "AP-4 mediates export of ATG9A from the trans-Golgi network to promote autophagosome formation." Proceedings of the National Academy of Sciences 114, no. 50 (November 27, 2017): E10697—E10706. http://dx.doi.org/10.1073/pnas.1717327114.
Повний текст джерелаSzurmak, Blanka, Aleksandra Wysłouch-Cieszyńska, Małgorzata Wszelaka-Rylik, Wojciech Bal, and Marta Dobrzańska. "A diadenosine 5',5''-P1P4 tetraphosphate (Ap4A) hydrolase from Arabidopsis thaliana that is activated preferentially by Mn2+ ions." Acta Biochimica Polonica 55, no. 1 (March 13, 2008): 151–60. http://dx.doi.org/10.18388/abp.2008_3173.
Повний текст джерелаДисертації з теми "AP-4 Complex"
Davies, Alexandra Katherine. "An investigation of the function of adaptor protein complex 4 (AP-4)." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289777.
Повний текст джерелаAngelica, D'Amore. "Next Generation Molecular Studies of Hereditary Spastic Paraplegias in Men and Zebrafish." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1105261.
Повний текст джерелаMüdsam, Christina [Verfasser], Norbert [Akademischer Betreuer] Sauer, and Norbert [Gutachter] Sauer. "Dissecting the role of adaptor protein complex 4 (AP-4) on development and protein sorting in Arabidopsis thaliana / Christina Müdsam ; Gutachter: Norbert Sauer ; Betreuer: Norbert Sauer." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2017. http://d-nb.info/1156780926/34.
Повний текст джерелаTavares, Lucas Alves. "O envolvimento da proteína adaptadora 1 (AP-1) no mecanismo de regulação negativa do receptor CD4 por Nef de HIV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/.
Повний текст джерелаThe Human Immunodeficiency Virus (HIV) is the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a disease which has a global distribution, and it is estimated that there are currently at least 36.9 million people infected with the virus. During the replication cycle, HIV promotes several changes in the physiology of the host cell to promote their survival and enhance replication. The fast progression of HIV-1 in humans and animal models is closely linked to the function of an accessory protein Nef. Among several actions of Nef, one is the most important is the down-regulation of proteins from the immune response, such as the CD4 receptor. It is known that this action causes CD4 degradation in lysosome, but the molecular mechanisms are still incompletely understood. Nef forms a tripartite complex with the cytosolic tail of the CD4 and adapter protein 2 (AP-2) in clathrin-coated vesicles, inducing CD4 internalization and lysosome degradation. Previous research has demonstrated that CD4 target to lysosomes by Nef involves targeting of this receptor to multivesicular bodies (MVBs) pathway by an atypical mechanism because, although not need charging ubiquitination, depends on the proteins from ESCRTs (Endosomal Sorting Complexes Required for Transport) machinery and the action of Alix, an accessory protein ESCRT machinery. It has been reported that Nef interacts with subunits of AP- 1, AP-2, AP-3 complexes and Nef does not appear to interact with AP-4 and AP-5 subunits. However, the role of Nef interaction with AP-1 or AP-3 in CD4 down-regulation is poorly understood. Furthermore, AP-1, AP-2 and AP-3 are potentially heterogeneous due to the existence of multiple subunits isoforms encoded by different genes. However, there are few studies to demonstrate if the different combinations of APs isoforms are form and if they have distinct functional properties. This study aim to identify and characterize cellular factors involved on CD4 down-modulation induced by Nef from HIV-1. More specifically, this study aimed to characterize the involvement of AP-1 complex in the down-regulation of CD4 by Nef HIV-1 through the functional study of the two isoforms of ?-adaptins, AP-1 subunits. By pull-down technique, we showed that Nef is able to interact with ?2. In addition, our data from immunoblots indicated that ?2- adaptin, not ?1-adaptin, is required in Nef-mediated targeting of CD4 to lysosomes and the ?2 participation in this process is conserved by Nef from different viral strains. Furthermore, by flow cytometry assay, ?2 depletion, but not ?1 depletion, compromises the reduction of surface CD4 levels induced by Nef. Immunofluorescence microscopy analysis also revealed that ?2 depletion impairs the redistribution of CD4 by Nef to juxtanuclear region, resulting in CD4 accumulation in primary endosomes. Knockdown of ?1A, another subunit of AP-1, resulted in decreased cellular levels of ?1 and ?2 and, compromising the efficient CD4 degradation by Nef. Moreover, upon artificially stabilizing ESCRT-I in early endosomes, via overexpression of HRS, internalized CD4 accumulates in enlarged HRS-GFP positive endosomes, where co-localize with ?2. Together, the results indicate that ?2-adaptin is a molecule that is essential for CD4 targeting by Nef to ESCRT/MVB pathway, being an important protein in the endo-lysosomal system. Furthermore, the results indicate that ?-adaptins isoforms not only have different functions, but also seem to compose AP-1 complex with distinct cell functions, and only the AP-1 variant comprising ?2, but not ?1, acts in the CD4 down-regulation induced by Nef. These studies contribute to a better understanding on the molecular mechanisms involved in Nef activities, which may also help to improve the understanding of the HIV pathogenesis and the related syndrome. In addition, this work contributes with the understanding of primordial process regulation on intracellular trafficking of transmembrane proteins.
Ku, Wei-Chi, and 辜韋智. "Complementary Quantitative Proteomics Reveals that Transcription Factor AP-4 Mediates E-Box-Dependent Complex Formation for Transcriptional Repression of HDM2." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/86812726367946597857.
Повний текст джерела國立清華大學
生物資訊與結構生物研究所
97
Transcription factor activating enhancer binding protein 4 (AP-4) is a basic helix-loop-helix protein that binds to E-box elements. AP-4 has received increasing attention for its regulatory role in cell growth and development, including transcriptional repression of the human homolog of murine double minute 2 (HDM2), an important oncoprotein controlling cell growth and survival, by an unknown mechanism. Here we demonstrate that AP-4 binds to an E-box located in the HDM2-P2 promoter in vitro and in vivo as demonstrated by electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP). Luciferase assay further revealed that AP-4 represses HDM2 transcription in a p53-independent manner. In addition, incremental truncations of AP-4 showed that the C-terminal glutamine/proline-rich domain is essential for transcriptional repression of HDM2. To further delineate the molecular mechanism(s) of AP-4 transcriptional control and its potential implications, we performed single-step DNA-affinity purification followed by complementary quantitative proteomics, cICAT and iTRAQ labeling methods, to identify a previously unknown E-box-bound AP-4 protein complex. The two labeling methods complementarily quantified 75 putative components in AP-4 protein complex, including the most significant recruitment of DNA damage–responsive proteins, followed by transcription factors, transcription repressors/corepressors, and histone-modifying proteins. Using AP-4 truncation mutants and DNA pull-down assay, specific interaction of AP-4 with CTCF, SP1, and histone deacetylase 1 (an AP-4 corepressor) was validated. Although AP-4 may repress HDM2 transcripion by recruiting HDAC, inclusion of HDAC specific inhibitor, trichostatin A, did not alleviate AP-4-mediated repression of HDM2 transcription. Taken together the data suggest a previously unidentified histone deacetylase-independent repression mechanism. Alternatively, the complementary quantitative proteomics study suggests that transcription repression occurs via coordination of AP-4 with other transcription factors, histone methyltransferases, and/or a nucleosome remodeling SWI/SNF complex. In addition to previously known functions of AP-4, our data suggest that AP-4 participates in a transcriptional regulating complex at the HDM2 promoter in response to DNA damage. In conclusion, we successfully demonstrate how AP-4 regulates HDM2 transcription via binding to the previously unknown AP-4 binding site. By taking the advantage of the complementary quantitative proteomics, we identify a DNA bound AP-4 protein complex from single-step DNA afftinity purification from crude nuclear extracts. By analyzing the components and functions of the AP-4 protein complex, we are able to deduce the possible repressive mechanisms on HDM2 transcription and the potential role of AP-4 in DNA damaging response. Our findling may shed a light in better understanding the physiological role of AP-4. Finally, we also develop a strategy combining single-step purification and complementary quantitative proteomics for target proteomics study, which provides an alternative MS-based way to study protein complex in the future.
Burgess, Jason. "The Clathrin Adaptor AP-1 and Type II Phosphatidylinositol 4-Kinase are Required for Glue Granule Biogenesis in Drosophila." Thesis, 2012. http://hdl.handle.net/1807/33847.
Повний текст джерелаЧастини книг з теми "AP-4 Complex"
Sergeevna Ageeva, Liliya, Nikolai Alekseevich Borsch, and Nikolay Vladimirovich Kuvardin. "2(4)-Aminopyridines as Ligands in the Coordination and Extraction Chemistry of Platinum Metals." In Exploring Chemistry with Pyridine Derivatives. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.106376.
Повний текст джерелаMakhlouf, Amel Meddeb, and Noureddine Boudriga. "Intrusion and Anomaly Detection in Wireless Networks." In Handbook of Research on Wireless Security, 78–94. IGI Global, 2008. http://dx.doi.org/10.4018/978-1-59904-899-4.ch006.
Повний текст джерела"Language and Communication Skills A child's competence withlanguage is highly likely to affect the extent and quality of her/his social relationships. As significant conversational ability develops at approximately 2Vi years, social interaction increases simultaneously (Holmberg, Note 2). Children whose language and comprehension skills are limited may be hampered in their ability to communicate and interact with •their peers. Certainly, the relationship between language com-petence and competence in other areas has been documented (Ap-pleton, Clifton, & Goldberg, 1975). Social play requires at least some level of adequate communi-cation skills (Asher, Oden, & Gottman, 1977), e.g., the ability to share a theme of an activity and develop it (Garvey, 1976). Little is known yet about the relative importance of deficits in specific com-munication skills, and further, few effects have been noted as a function of training. It is probable that children with less verbal ability, e.g., younger or handicapped, are less likely to profit from skills training involving verbal instruction or complex language per-formance. And. whereas language skills may not be related to social competence among prelingual toddlers, as the child develops, lan-guage may play a more crucial role. Preliminary analyses of our data show a significant but low correlation between measures of listener vocabulary and knowledge of basic concepts in preschool children and both teacher ratings of social behavior and peer popularity. It appears, then, that language has some role to play in a child's social competence, and the practitioner would be wise to consider the socially withdrawn child's language capabilities before at-tempting remediations which otherwise may prove ineffective. Motor Skills A series of studies of elementary school children from 4th through 7th grades found consistent and significant relationships between their performance on physical measures and social status as measured by socio-metrics (Broekhoff, 1976, 1977, in press). Com-parisons of high and low status contrast groups indicated that signifi-cant differences were maintained over the three years on physical fitness and indices of muscular strength. Thus, it seems logical to." In Social Skills Training for Children and Youth, 45–50. Routledge, 2014. http://dx.doi.org/10.4324/9781315059167-4.
Повний текст джерелаТези доповідей конференцій з теми "AP-4 Complex"
Alecu, Julian E., Marvin Ziegler, Barbara Brechmann, Kathrin Eberhardt, Hellen Jumo, Angelica D’Amore, Afshin Saffari, et al. "High-Throughput Imaging of ATG9A Distribution as a Diagnostic Functional Assay for Adaptor Protein Complex 4: Associated Hereditary Spastic Paraplegia (AP-4-HSP)." In Abstracts of the 46th Annual Meeting of the Society for Neuropediatrics. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1739686.
Повний текст джерелаHolmes, W. E., H. R. Lijnen та D. Collen. "CHARACTERIZATION OFα2-ANTIPLASMIN.REACTIVE SITE VARIANTS PRODUCED BY SITE-DIRECTED MUTAGENESIS". У XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644766.
Повний текст джерелаMysliwiec, M., D. Alderson, L. Poller, and P. Ackrill. "PROTEIN C AND OTHER CLOTTING STUDIES IN MEMBRANOUS AND NON-MEMBRANOUS GLOMERULONEPHRITIS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644310.
Повний текст джерелаRiccardi, Fabio, Federico DelGrande, Giuliano Prando, Valentina Giuliani, Matteo Pecoraro, and Andrea Ragazzi. "NGCTR-TD Tiltrotor Autorotation Numerical Investigation." In Vertical Flight Society 78th Annual Forum & Technology Display. The Vertical Flight Society, 2022. http://dx.doi.org/10.4050/f-0078-2022-17551.
Повний текст джерелаPereira, Berta Vaz Andrade de Faria, Júlia Raquel Silva do Ó, Deon Vinicius Moreira Pimentel, Daniela Textor, Fabiana Chaveiro Gomes, and Marina Araújo e. Rocha. "Acretismo placentário com invasão extensa de estruturas adjacentes: um relato de caso." In 45º Congresso da SGORJ XXIV Trocando Ideias. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/jbg-0368-1416-20211311107.
Повний текст джерела"THC COMO PRECIPITANTE DE PSICOSIS. A PROPÓSITO DE UN CASO." In 23° Congreso de la Sociedad Española de Patología Dual (SEPD) 2021. SEPD, 2021. http://dx.doi.org/10.17579/sepd2021p027v.
Повний текст джерела