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Статті в журналах з теми "Antonio de Curtis":

1

Curtis, Christina. "Abstract ED7-4: Beyond the lab: Clinical implications." Cancer Research 83, no. 5_Supplement (March 1, 2023): ED7–4—ED7–4. http://dx.doi.org/10.1158/1538-7445.sabcs22-ed7-4.

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Abstract During this talk, I will review the ever expanding repertoire of single cell and spatially resolved profiling techniques which enable the interrogation breast cancer pathlogy, immuno-biology and treatment response at unprecedented resolution. I will outline considerations for throughput, plex and resolution across different methods before providing several case studies in their application. As one example, I will outline the use of multi-omic single cell profiling and spatial proteomic profiling to characterize changes throughout the course of neoadjuvant Her2-targeted therapy and leading to the identification of candidate predictive biomarkers. I will go on to discuss translational and potential clinical applications of these techniques. Citation Format: Christina Curtis. Beyond the lab: Clinical implications [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr ED7-4.
2

Poole, Gordon. "Totò’s talking body." Gesture 7, no. 2 (June 19, 2007): 241–53. http://dx.doi.org/10.1075/gest.7.2.06poo.

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The full-bodied, multi-faceted use of gesture by Italy’s beloved vaudeville and cinema comedian Antonio De Curtis, in art Totò, is rooted in the rich gesture language of Naples. Totò’s humble origins, the experience of poverty and deprivation, conditioned his art, as did his immersion as a mere child into the rough-and-tumble world of Neapolitan street theater. The teeming neighborhoods of Naples, a Baroque city, have made it into somewhat of a theatrum mundi, producing many fine actors and playwrights. The essay, illustrated by photograms from a few of Totò’s films, suggests that Neapolitan gesture, whose purpose is communication, is stylized by Totò and transformed into artistry of a high order.
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Merino Gómez, Elena, Fernando Moral Andrés, and Alexandra Delgado Jiménez. "conversando con...RCR arquitectes. Parte I: De los límites del dibujo. Nostalgia de la ingravidez." EGA Revista de expresión gráfica arquitectónica 23, no. 34 (November 27, 2018): 24. http://dx.doi.org/10.4995/ega.2018.10934.

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<p>RCR arquitectes comparten sistemas de representación con otras oficinas de igual entidad. La homogenización que la digitalización tiende a imponer nos conduce a localizar un importante repertorio de representaciones gráficas similares a lo largo y ancho de Occidente. Toda la normativa que condiciona el conjunto de los proyectos que salen de los despachos también acentúa esta lectura uniforme. En cualquier caso es posible localizar alteraciones específicas de cada despacho que nos presentan realidades diferentes y enriquecedoras para el panorama gráfico arquitectónico. Probablemente en estas anomalías es donde se revela el espíritu más singular que anida en cada oficina, también en la de Rafael, Carme y Ramón.</p><p>No existe una gran literatura que ayude a descifrar la importancia, capital, que tienen sus dibujos en el conjunto de su trayectoria. Indudablemente, sus aguadas configuran el torrente necesario del que se nutren sus obras. Es una técnica que ha caracterizado su identidad como estudio a lo largo de estos años de trabajo. Como apuntan, es un instrumento con un recorrido casi automático entre el pensamiento y el brazo. Un camino ágil que les conduce a presentar sus ideas de forma vigorosa y abstracta. Esas manchas de agua tintada permiten una lejanía prudencial con respecto a la forma última que adoptará la propuesta y facilitan el debate conceptual, la esencia genuina de sus aportaciones. Esos dibujos, de diferentes formatos, pueden ser más o menos precisos (o difusos) contaminados, generalmente, con trazos y apuntes de gruesa lapicera que buscan fijar matices y preceptos que articulan el proyecto venidero. Este material trasluce el compromiso máximo entre los arquitectos y su trabajo. RCR no opera desde una inercia superficial, todas sus obras concentran una rica cantidad de variantes que certifican ese extenuante trabajo intelectual. William J. R. Curtis apunta que sus creaciones, gráficas y constructivas, se desarrollan durante un proceso largo pero armonioso, evidencia esa ligación, necesaria, que existe entre ambas facetas de su quehacer profesional (Curtis, 2017, p.6).</p><p>En 2007 el catedrático Juan Antonio Cortés evidenciaba, bajo el epígrafe de “Naturaleza, pintura, arquitectura” ciertas reflexiones que ligaban a la arquitectura de RCR con cuestiones rítmicas trabajadas por el pintor Pierre Soulages y también con la aseveración de la existencia de un estilo propio de la oficina cimentado a través de diferentes variaciones ancladas a una concepción específica (personal) del hecho arquitectónico (Cortés, 2007, p.22). Sus dibujos son claves para llegar a comprender esta realidad intelectual, singular como pocas, y en continua búsqueda de esencias que sustancien nuevas intervenciones nacidas desde un trazo grueso. En este punto se hace necesario señalar cómo la arquitectura de su oficina es un referente internacional de primera magnitud pero el camino que apuntan sus dibujos, en sí mismos, nos hace atisbar una “vis artística” de poderosa constitución. Sin duda alguna, el futuro confirmará esta eclosión pictórica dentro del universo creativo de RCR.</p>
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Houlahan, Kathleen, Aziz Khan, Noah Greenwald, Robert West, Michael Angelo, and Christina Curtis. "Abstract GS03-11: Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity." Cancer Research 84, no. 9_Supplement (May 2, 2024): GS03–11—GS03–11. http://dx.doi.org/10.1158/1538-7445.sabcs23-gs03-11.

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Abstract Background: Somatic genomic aberrations are acquired within the context of germline genomes which differ across individuals at millions of polymorphic sites. However, the role of germline variation in somatic evolution remains poorly understood. The most compelling example is is that deleterious germline variants in BRCA1 and, to a lesser extent, BRCA2 are preferentially associated with the development of triple-negative breast cancer (BC). The variable frequency of BC subtypes across ancestral populations further suggests a role for germline contributions. On the other hand, various lines of evidence indicate that avoidance of the adaptive immune system is a strong determinant of which somatic mutations persist within a tumor. Whether and how germline differences influence immunoediting has not been studied. Building on these observations, we sought to investigate whether germline variation mediates somatic evolution through immunoediting. Specifically, we hypothesize inherited variation in oncogenes would be subject to varied immunoediting pressures during malignant transformation and progression. A high burden of germline-derived epitopes in recurrently amplified oncogenes is predicted to select against amplification of the cognate gene during malignant transformation because this would increase epitope availability, the likelihood of epitope presentation, and immune-mediated cell death. Instead, immune pressures may select for amplification of an alternate driver gene with a lower germline-mediated epitope burden. We evaluated this hypothesis in a collection of 3,855 BC, spanning ductal carcinoma in situ (DCIS) to invasive BC, and metastatic lesions. Methods: We analyzed paired tumor and normal sequencing data from 1,087 primary and 702 metastatic breast cancer patients as well as somatic genomic profiles from 341 patients with DCIS using a novel algorithm to estimate germline-derived epitope burden (GEB) based on an individual’s genotype and class 1 HLA alleles. The relationship between GEB and subtype commitment, defined by the acquisition of focal oncogenic amplifications in five prognostic subgroups of BC: HER2+ disease and four high-risk of relapse ER+/HER2 integrative subgroups/clusters (ICs) which we previously described (IC1: 17q23, IC2: 11q13, IC6: 8p12, and IC9: 8q24) was evaluated. Specifically, we evaluated the association between the GEB per gene and whether an individual developed the corresponding subtype via logistic regression, correcting for the first six genetic principal components and somatic mutation burden. Outcome associations were evaluated via Cox Proportional Hazards Models. Results: Interrogating 3,855 breast cancer lesions, we demonstrate that germline-derived epitopes in recurrently amplified genes influence somatic evolution by mediating immunoediting. Individuals with a high GEB in ERBB2/HER2 are significantly less likely to develop HER2-positive breast cancer compared to other subtypes. The same holds true for recurrent amplicons that define four aggressive, high-risk of relapse, ER-positive integrative subgroups. Thus, GEB selects against cognate oncogene amplification. Tumors that overcome such immune-mediated negative selection are more aggressive and exhibited microenvironments depleted of lymphocytes, consistent with “immune cold” tumors. Conclusions: We demonstrate that inherited variation sculpts breast cancer subtypes, aggressivity, and immune landscapes by mediating anti-tumor immune responses. The implications of these findings are severalfold. First, GEB is prognostic, complementing other molecular measurements. Second, immunoediting pressures differ across the disease course, with implications for the timing of therapeutic interventions. Third, these data illuminate a broad source of currently under-appreciated immunogenic antigens. Citation Format: Kathleen Houlahan, Aziz Khan, Noah Greenwald, Robert West, Michael Angelo, Christina Curtis. Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr GS03-11.
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Cole, Kimberly, Melissa Tjota, Jeremy Segal, Peng Wang, and Susanne Crespo-Ramos. "Abstract PO5-24-06: Genomic findings in metastatic breast cancer." Cancer Research 84, no. 9_Supplement (May 2, 2024): PO5–24–06—PO5–24–06. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-24-06.

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Abstract Introduction: Although metastatic breast cancer is the second leading cause of cancer death in women, the genomic findings in metastatic breast cancer are not as well characterized as those of primary breast cancers. Metastatic tumors are genetically heterogenous, enriched for resistance mutations, and often lack targetable alterations. Improved understanding of the molecular mechanisms that drive metastatic disease of all receptor subtypes is required to identify possible molecular targets and to develop new targeted therapies in an effort to reduce the mortality. Methods: A cohort of 50 metastatic breast cancer cases (n=33 ER+/PR+, n=3 ER+/HER2+, n=3 ER-/HER2+ n=11 TNBC) sequenced at our medical center between 2018-2023 was evaluated, and the molecular findings of the major subtypes were analyzed. Genomic data included mutations, copy number alterations, tumor mutation burden and microsatellite instability. Results: The most frequent somatic alteration were PIK3CA mutations, involving 17/33 of ER+/PR+/HER- tumors, 5/11 TNBC tumors and 5/6 HER+ cases. TP53 mutations (frameshift and missense) were more frequently identified in TNBC and HER2+ cases (p&lt; 0.05). Recurrent CCND1, FGFR1 and MYC copy number amplifications were seen almost exclusively in hormone receptor positive/HER2- tumors (p &gt;0.05). ESR1 mutations involved 15% of the ER positive cancers and were frequently associated with co-occurring CCND1 and FGFR1 copy number gains. Significant genomic losses that drive tumorigenesis were also detected. Both CDKN2a and PTEN deletions were found in ER/PR positive disease, as well as triple negative tumors. Genomic deletions associated with worse outcomes such as TP53 and DICER1 were also detected. ERBB2 amplification was 100% concordant with our immunohistochemical and FISH results for the 6 HER2 positive cases. All 50 cases demonstrated a low tumor mutation burden and were microsatellite stable. Conclusion: We detected driver alterations that involve multiple pathways including estrogen receptor signaling, PI3K/AKT/MTOR, the cell cycle, and receptor tyrosine kinases. The genomic alterations are enriched for resistance mechanisms, like ESR1 mutations and FGFR1 gains that mediate resistance to endocrine treatment, as well as PIK3CA, also implicated in both endocrine and HER2-targeting therapy resistance. Of particular interest, were the amplifications detected in the ER+/PR+ tumors, such as CCND1 on chromosome 11q, FGFR1 on 8p and MYC on 8q, which were detected in almost half (45%) of our hormone receptor positive cohort. Some of the identified driver amplifications also define a subset of the Integrated Molecular Subtypes (Curtis et al., Nature; 486(7403): 346–352), i.e., Clusters 2, 6 and 9 that are typically hormone receptor positive but associated with either a very poor prognosis (Cluster 2) or an intermediate prognosis (Clusters 6 and 9), unlike the copy neutral ER positive tumors or those with the classic 1p and 16q alterations. Therefore, copy number profiling of advanced-stage breast cancers may be a useful tool for determining prognosis, identifying possible targetable driver pathways and selecting appropriate patients for molecularly guided clinical trials. Citation Format: Kimberly Cole, Melissa Tjota, Jeremy Segal, Peng Wang, Susanne Crespo-Ramos. Genomic findings in metastatic breast cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-24-06.
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Strand, Siri H., Belén Rivero-Gutiérrez, Kathleen E. Houlahan, Jose A. Seoane, Lorraine M. King, Tyler Risom, Lunden Simpson, et al. "Abstract GS4-07: The Breast PreCancer Atlas DCIS genomic signatures define biology and correlate with clinical outcomes: An analysis of TBCRC 038 and RAHBT cohorts." Cancer Research 82, no. 4_Supplement (February 15, 2022): GS4–07—GS4–07. http://dx.doi.org/10.1158/1538-7445.sabcs21-gs4-07.

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Abstract Background. DCIS consists of a molecularly heterogeneous group of premalignant lesions, with variable risk of invasive progression. Understanding biomarkers for invasive progression could help individualize treatment recommendations based upon tumor biology. As part of the NCI Human Tumor Atlas Network (HTAN), we conducted comprehensive genomic analyses on two large DCIS case-control cohorts. Methods. We performed smart3-seq and low-pass whole genome sequencing on two independent, retrospective, longitudinally sampled DCIS case-control cohorts. TBCRC 038 was a multicenter cohort diagnosed with DCIS between 1998 and 2016 at one of the Translational Breast Cancer Research sites; the RAHBT (Resource of Archival Human Breast Tissue) cohort included women identified through the St. Louis Breast Tissue Repository, and the Women’s Health Repository diagnosed between 1997 and 2001. We studied the spectrum of molecular changes present and sought genomic predictors of subsequent ipsilateral breast events (iBEs: DCIS recurrence or invasive progression) in both DCIS epithelium and stroma in formalin fixed paraffin embedded tissue. We generated de novo tumor and stroma-centric subtypes for DCIS that represents fundamental transcriptomic organization. Copy number analysis was performed using low-pass DNA sequencing. Non-negative matrix factorization (NMF) was applied to the RNA expression of all coding genes to identify clusters. A negative-binomial regression model was used to identify differentially expressed genes. Results. We analyzed 677 DCIS samples from 481 patients with 7.1 years median follow-up. In TBCRC samples, we identified three clusters via NMF in TBCRC referred to as ER low, quiescent, and ER high. The ER-low cluster had significantly higher levels of ERBB2 and lower levels of ESR1 compared to quiescent and ER-high clusters. Quiescent cluster lesions were less proliferative and less metabolically active than ER high and ER low subtypes. These findings were replicated in the RAHBT cohort. Focusing on the stromal component of DCIS from laser capture microdissection in RAHBT samples, we identified four distinct DCIS-associated stromal clusters. A “normal-like” stromal cluster with ECM organization and PI3K-AKT signaling; a “collagen-rich” stromal cluster; a “desmoplastic” stromal cluster with high fibroblast and total myeloid abundance, mostly associated with macrophages and myeloid dendritic cells (mDC); and an “immune-dense” stromal cluster. Further, we compared differentially expressed genes in patients with or without subsequent iBEs within 5 years of diagnosis. Hypothesizing that the resulting 812 DE genes (DESeq2) represent multiple routes to subsequent iBEs, we leveraged NMF to identify paths to progression. In both TBCRC and RAHBT cohorts, poor outcome groups exhibited increased ER, MYC signaling, and oxidative phosphorylation, supporting that these pathways are important for DCIS recurrence and progression. Conclusion. Comprehensive genomic profiling in two independent DCIS cohorts with longitudinal outcomes shows distinct DCIS stromal expression patterns and immune cell composition. RNA expression profiles reveal underlying tumor biology that is associated with later iBEs in both cohorts. These studies provide new insight into DCIS biology and will guide the design of diagnostic strategies to prevent invasive progression. Citation Format: Siri H Strand, Belén Rivero-Gutiérrez, Kathleen E Houlahan, Jose A Seoane, Lorraine M King, Tyler Risom, Lunden Simpson, Sujay Vennam, Aziz Khan, Timothy Hardman, Bryan E Harmon, Fergus J Couch, Kristalyn Gallagher, Mark Kilgore, Shi Wei, Angela DeMichele, Tari King, Priscilla F McAuliffe, Julie Nangia, Joanna Lee, Jennifer Tseng, Anna Maria Storniolo, Alastair Thompson, Gaorav Gupta, Robyn Burns, Deborah J Veis, Katherine DeSchryver, Chunfang Zhu, Magdalena Matusiak, Jason Wang, Shirley X Zhu, Jen Tappenden, Daisy Yi Ding, Dadong Zhang, Jingqin Luo, Shu Jiang, Sushama Varma, Cody Straub, Sucheta Srivastava, Christina Curtis, Rob Tibshirani, Robert Michael Angelo, Allison Hall, Kouros Owzar, Kornelia Polyak, Carlo Maley, Jeffrey R Marks, Graham A Colditz, E Shelley Hwang, Robert B West. The Breast PreCancer Atlas DCIS genomic signatures define biology and correlate with clinical outcomes: An analysis of TBCRC 038 and RAHBT cohorts [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr GS4-07.
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Mattick, Lindsey, Hongying Sun, Karen Mustian, Luke Peppone, AnnaLynn Williams, Po-Ju Lin, Evelyn Arana, et al. "Abstract PO4-12-09: National Physical Activity Guidelines and It’s Association with Fatigue in Patients with Breast Cancer Pre- and Post-Chemotherapy in a Prospective, Nationwide Study." Cancer Research 84, no. 9_Supplement (May 2, 2024): PO4–12–09—PO4–12–09. http://dx.doi.org/10.1158/1538-7445.sabcs23-po4-12-09.

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Abstract Background: Cancer-related fatigue (CRF) is one of the most pervasive side effects of cancer and its treatment, reported by nearly 90% of patients. Physical activity (PA) during treatment may prevent or lessen CRF burden. Current aerobic PA guidelines for cancer patients recommend at least 150 minutes of moderate PA or 75 minutes of vigorous PA or some equivalent combination of moderate and vigorous PA (MVPA). Many patients have difficulty meeting these guidelines during treatment, however, meeting these guidelines may not be necessary to alleviate CRF. This study evaluated patterns of PA below the recommended guidelines and their association with CRF in cancer patients during treatment. Methods: In a nationwide, prospective cohort study of patients with stage I-IIIC breast cancer (n=580) we assessed the relationship between self-reported PA (Aerobics Center Longitudinal Study PA) and CRF (Multidimensional Fatigue Symptom Inventory, MFSI) pre- and post-chemotherapy. Spearman correlations were utilized to evaluate the association of all PA (MET hr/wk) and MVPA (MET hr/wk) with overall CRF (total MFSI) and 5 CRF subdimensions (general, physical, emotional, mental CRF and vigor) at pre- and post-chemotherapy. ANCOVA estimated mean CRF score according to whether patients weekly MVPA (1) met 100% of the PA guidelines, (2) met 50%-99% of the PA guidelines (75-149 minutes), or (3) did not meet 50% of the PA guidelines (&lt; 75 minutes). Results: Pre-chemotherapy, only 34% of participants met the PA guidelines, post-chemotherapy, only 21% of patients met the PA guidelines. At both time points, we observed small to moderate inverse correlations of MVPA with overall CRF and several subdimensions of CRF (Table 1; r = -0.11, -0.19). Pre-chemotherapy, those who did not meet 50% of the PA guidelines report significantly higher total CRF compared to those who met the PA guidelines (12.5 ± 1.2 vs 5.3 ± 1.5; p&lt; 0.001). However, those who met only 50%-99% of the PA guidelines, had comparable total CRF to those who fully met the PA guidelines (7.2 ± 2.2; p=0.474). A similar pattern was observed for the subdimensions general, mental, and physical CRF. Those who met 50% of the guidelines also had significantly lower vigor compared to those who met the guidelines (11.9 ± 0.3 vs 13.8 ± 0.4; p&lt; 0.001), while those who met 50%-99% of the guidelines had comparable vigor to those who fully met guidelines (13.1 ± 0.6; p=0.278). Post-chemotherapy CRF was higher among all patient’s, again there was no significant difference in total, general, physical CRF and vigor between those who met the PA guidelines and those who met 50%-99% of the PA guidelines. Conclusions: All PA was consistently inversely associated with CRF pre- and post-chemotherapy for patients with breast cancer. Current minimum aerobic PA guidelines for patients with cancer are difficult to achieve during treatment. Lower doses of MVPA than the current PA guidelines suggest may provide equal benefit and represent a more achievable goal for patients with cancer. Table 1: Spearman correlations of CRF and physical activity in patients with breast cancer pre- and post-chemotherapy. Table 2: ANCOVA; Mean CRF score according to the PA guidelines. Citation Format: Lindsey Mattick, Hongying Sun, Karen Mustian, Luke Peppone, AnnaLynn Williams, Po-Ju Lin, Evelyn Arana, Jeremy McGuire, Amarinthia Curtis, Alison Conlin, Lora Weiselberg, Michelle Janelsins. National Physical Activity Guidelines and It’s Association with Fatigue in Patients with Breast Cancer Pre- and Post-Chemotherapy in a Prospective, Nationwide Study [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO4-12-09.
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Pisano, Etta, Constantine Gatsonis, Mitchell Schnall, Melissa Troester, Elodia Cole, Jean Cormack, Ilana Gareen, et al. "Abstract PO3-19-03: Addressing USPSTF 2023 Identified Key Gaps in Knowledge in Breast Cancer Screening through TMIST (ECOG-ACRIN EA1151) or its Ancillary Studies." Cancer Research 84, no. 9_Supplement (May 2, 2024): PO3–19–03—PO3–19–03. http://dx.doi.org/10.1158/1538-7445.sabcs23-po3-19-03.

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Abstract Background The United States Preventative Services Task Force in their 2023 recommendations identified areas where more research data is needed to inform future breast cancer screening recommendations. Research areas identified are: improve clinicians and patients understanding and evaluation of dense breast tissue on a screening mammogram, benefits and harms of supplemental screening using ultrasound or MRI for women with dense breasts, health outcomes such as rates of breast cancer diagnosis requiring treatment, rates of advanced breast cancers diagnosed across consecutive screening rounds, and breast cancer-associated morbidity and mortality, causes of increased risk of breast cancer mortality in black women across spectrum of stages and biomarker patterns, understand why black women are more likely to be diagnosed with breast cancers that have biomarker patterns that are indicative of poor health outcomes, assess benefits/harms differences between annual and biennial screening for breast cancer in women overall and if there are differences between black and white women, approaches to reduce the risk of overdiagnosis leading to overtreatment of breast lesions found at screening that may not cause morbidity and mortality, natural history of DCIS, and identify prognostic indicators of breast tumors that are unlikely to affect quality or length of life. Methods The ongoing TMIST study, currently with 88,801 asymptomatic women presenting for screening mammography ages 45-74 enrolled out of 128,905, could contribute to scientific evidence to support the above research areas through existing study aims and planned ancillary studies. Supplemental Screening with US and MRI: TMIST PreSCRIB will utilize Machine Learning applied to TMIST and All of Us data, including genetics, mammograms, social determinates of health and other data to recommend individualized screening strategies for women. DxMRI is a study where women will get AbMRI at time of Dx work-up. There are plans to use these examinations plus supplemental screening MRIs performed on TMIST subjects in an enriched reader study to evaluate the role of supplemental screening MRI in moderate risk women. Rates of breast cancer treatment, consecutive screening, morbidity, and mortality: TMIST’s primary outcome is the proportion of women experiencing an advanced breast cancer and needing treatment. TMIST is also collecting information on health care utilization following a cancer diagnosis, including types of treatment given, and costs data from the screening and diagnostic work-up visits, and mortality data for study participants. Increased risk of breast cancer mortality in black women: TMIST is performing PAM50 plus p53 status, immune profile, DNA repair phenotype, and 21-gene recurrence assay on all breast cancers and a subset of benign tissue. Blood and buccal smears might also help address this issue. Ongoing work, funded by the Susan B. Komen Foundation, focuses on improving Black participation in TMIST Biorepository (currently about 45% participation of the 21% of TMIST US black subjects). Surveys are planned on perceived racism and social determinates of health as part of DxMRI Study. Screening Frequency: We are developing a collaboration with the UK-based clinical trial PROSPECTS to compare rates of all cancers and advanced cancers for annual, biennial, and 3-year screening. Overdiagnosis, natural history of DCIS, prognostic indicators of breast tumors not impacting quality of life: PRoGram- will use radiomics, genomics and pathomics to develop a greater understanding of the variability of the non-advanced cancers diagnosed in the TMIST population, including DCIS. It is hoped that this model will provide greater understanding of the risk of poor outcomes for women diagnosed with lower risk cancers, including DCIS. Citation Format: Etta Pisano, Constantine Gatsonis, Mitchell Schnall, Melissa Troester, Elodia Cole, Jean Cormack, Ilana Gareen, Martin Yaffe, Laura Collins, Amarinthia Curtis, Ruth Carlos, Kathy Miller, Christopher Comstock. Addressing USPSTF 2023 Identified Key Gaps in Knowledge in Breast Cancer Screening through TMIST (ECOG-ACRIN EA1151) or its Ancillary Studies [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-19-03.
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Fogal, Alex Alves. "O MÉTODO CRÍTICO DE ANTONIO CANDIDO E A ANÁLISE DA FORMA POÉTICA." Via Atlântica, no. 35 (July 10, 2019): 13–25. http://dx.doi.org/10.11606/va.v0i35.154614.

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O objetivo desse artigo é refletir sobre método crítico de Antonio Candido especificamente no que diz respeito aos textos poéticos. Para isso, serão analisados dois textos pouco estudados do autor: Na sala de Aula e O estudo analítico do poema. O foco é tentar demonstrar que esses dois livros, apesar de curtos, demonstram a mesma força crítica que Antonio Candido apresenta em suas obras mais conhecidas. Neles, o crítico ressalta a importância do apego à matéria textual na análise dos poemas, apresentando um modelo de análise que deve sempre ter o concreto como ponto de partida. Junto a isso, coloca em evidência uma noção de forma poética fundamentada por uma reflexão dialética, oposta à ideia de que poesia é somente um jogo de linguagem ou um malabarismo técnico.
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Goddu, André. "Ludwik Antoni Birkenmajer and Curtis Wilson on the Origin of Nicholas Copernicus’s Heliocentrism." Isis 107, no. 2 (June 2016): 225–53. http://dx.doi.org/10.1086/687031.

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Дисертації з теми "Antonio de Curtis":

1

Hachet, Elodie. "Totò. Des origines à l’original : La figure d’Antonio de Curtis dit « Totò » dans le cadre de la dramaturgie comique." Electronic Thesis or Diss., Paris 8, 2022. http://www.theses.fr/2022PA080005.

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Antonio de Curtis dit « Totò » est considéré comme l’un des plus grands acteurs du XXe siècle, ayant suscité l’admiration des cinéastes majeurs de son temps comme du public. Figure comique, burlesque, grotesque, parfois provocatrice, mais aussi légère et sublime, l’art singulier de Totò a pu s’exprimer aussi bien au cinéma qu’au théâtre. Cette thèse d’études cinématographiques s’appuie sur des éléments anthropologiques et historiques afin d’analyser le phénomène Totò dans toutes ces dimensions. L’étude des racines napolitaines de l’acteur permet d’apprécier toute la richesse de son jeu et de sa gestuelle, ne serait-ce que dans le premier sketch de "L'Or de Naples" où il interprète un pazzariello. Cet élément carnavalesque est nourri des analyses sur des rôles spécifiquement liés à la culture napolitaine, et, dans cette culture, l’usage du rire, de l’ironie et de la dérision. En effet, ces clés de lecture et d’interprétation rendent possible la compréhension du succès jamais démenti de Totò auprès d'un public qui en perçoit, même inconsciemment, toute la subtilité
Antonio de Curtis, known as “Totò”, is considered one of the greatest actors of the 20th century, having aroused the admiration of major filmmakers of his time and of the public. A comic, burlesque, grotesque, sometimes provocative figure, but also light and sublime, the singular art of Totò was able to express itself both in cinema and in theater. This thesis of cinematographic studies is based on anthropological and historical elements in order to analyze the Totò phenomenon in all these dimensions. The study of the Neapolitan roots of the actor makes it possible to appreciate all the richness of Totò’s acting and gestures, exemplified in the first sketch of "L'Or de Naples" where he performs a pazzariello. This carnival theme is filled with analyzes of roles specifically linked to Neapolitan culture and, in this culture, of laughter, irony and derision. Indeed, these keys of reading and interpretation open up an understanding of the undoubted success of Totò with an audience that perceives all its subtlety
2

Krause, Miller Stanley. "PROSE RHYTHM IN THE ORATIONS AND EPISTLES OF MARCUS ANTONIUS MURETUS." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_theses/599.

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Marcus Antonius Muretus, the sixteenth century French and Italian Humanist orator and professor, employed, in his orations and, to a lesser degree, in his epistles, a system of metrical prose rhythm (numerus) consistent with Ciceronian practice. Muretus did not, however, seek to employ accentual prose rhythms (cursus) characteristic of medieval prose; nevertheless, such rhythms arose naturally in his work as a byproduct of metrical prose rhythm. These findings, confirmed by statistical analysis, are congruent with the assumption that Humanist authors preferred Ciceronian stylistics to those associated with the “middle ages,” in accord with the tripartite Humanist narrative of history, in which the Humanists usher in a Renaissance of learning and elegance lost by preceding centuries.
3

Kornmeier, Uta. "Taken from life." Doctoral thesis, Humboldt-Universität zu Berlin, Philosophische Fakultät III, 2006. http://dx.doi.org/10.18452/15547.

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Wachsfigurenkabinette waren nicht immer die billigen Sensationsmaschinen, als die sie heute verstanden werden. Vor der Erfindung und Verbreitung von Photographie und illustrierten Zeitschriften waren sie Bildmedien, die der Vermittlung von visuellen Informationen dienten. Kein anderes Medium konnte die Protagonisten der Weltgeschichte so unmittelbar darstellen wie die Sammlungen lebensgroßer Wachsfiguren. Das Material Wachs trug wesentlich zu ihrem Erfolg bei, denn es ermöglichte die täuschend echten und bis dahin realistischsten Darstellungen von bekannten Persönlichkeiten. Die Operationsweise dieses Mediums wird am Beispiel von Madame Tussauds Wachsfigurenkabinett genauer untersucht. Dazu wurde, soweit möglich, die Reiseroute, der Aufbau und die “Besetzung” der Ausstellung rekonstruiert, sowie die soziale Herkunft der Besucher in der ersten Hälfte des 19. Jh.s ermittelt. Es wird deutlich, daß Marie Tussaud eine talentierte Portraitkünstlerin und ambitionierte Schaustellerin war, deren sorgfältig gestaltete Ausstellung vor allem Besucher der aufstrebenden Mittelschicht mit Interesse an Menschenkenntnis anzog. Das Wachsfigurenkabinett fiel damit in die Kategorie der “nützliche Unterhaltung”, die der Wissens- und Charakterbildung diente. Madame Tussaud ist vielleicht die bekannteste Betreiberin eines Wachsfigurenkabinetts – keinesfalls aber die erste. Die Geschichte der kommerziellen Ausstellung lebensgroßer Wachsfiguren reicht ins beginnende 17. Jh. zurück, wobei sich das Konzept der Kabinette im Laufe der Jahrhunderte stark gewandelt hat. In dieser Arbeit werden drei Ausstellungsformen unterschieden: a) das barocke Figurengruppen-Kabinett, das programmatische oder allegorische Geschichten erzählt, b) die aufklärerische Portraitgalerie (wie z.B. Madame Tussauds), in der Persönlichkeiten als charakteristische Individuen vorgestellt werden, c) das moderne Tableau-Kabinett, wo alltägliche oder außergewöhnliche Ereignisse auf bis dahin unübertroffen realistische Weise wiedergegeben werden. Als Nachrichtenkanal und als Medium für realistische Wirklichkeitswiedergabe sind Wachsfigurenkabinette seit den 1920er Jahren überholt. Als Spiel mit der menschlichen Sinneswahrnehmung bleiben sie jedoch vorerst aktuell.
Waxworks were not always the cheap sensation spinners as which we perceive them today. Before the invention and wide-spread use of photography and illustrated magazines they were an important medium for distributing visual information. No other form of communication could offer such immediate representations the protagonists of world history. Perhaps the greatest part in their success took the material wax which allowed the creation of deceptively lifelike and hitherto most realistic depictions of celebrated individuals. In this thesis, Madame Tussaud’s serves as a prime example for examining the mode of operation of a waxwork exhibition. As far as the sources allow, the itinerary, the ‘cast’ and display of the exhibition is reconstructed, as well as the number and the social background of its visitors during the first half of the 19th century. It emerges that Marie Tussaud was a talented portrait artist and a show woman of ambition whose carefully constructed exhibition attracted mainly middle-class visitors with an interest in human classification. Thus, the waxworks was a ‘rational entertainment’ that was thought to further the development of knowledge and character in its visitors. While Madame Tussaud’s was perhaps the most famous waxworks, it was not the first one. The history of commercial exhibition of life-sized wax figures goes back to the 17th century. Their concept, however, changed significantly over the centuries. Three forms of waxworks are differentiated here: a) the baroque waxworks of groups of figures narrating programmatic and allegorical stories, b) the enlightened portrait gallery – such as Madame Tussaud’s – where celebrities are presented as individual characters, c) the modern tableau waxworks, that represents extraordinary as well as everyday events in a realistic way that was hitherto unprecedented. As a channel for the distribution of news and as a medium for representing reality waxworks have become outdated. As a tickle for the senses, however, they will yet remain effective.
4

FEDERICO, LUCA. "L'apprendistato letterario di Raffaele La Capria." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/1005664.

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Superati «novant’anni d’impazienza» e dopo un lungo periodo votato all’autocommento e all’esplorazione delle proprie intenzioni, Raffaele La Capria ha raccolto le sue opere in due Meridiani curati da Silvio Perrella. La Capria ne ha celebrato l’uscita nella prolusione inaugurale di Salerno Letteratura, poi confluita nel breve autoritratto narrativo "Introduzione a me stesso" (2014). In questa sede, l’autore è tornato su alcuni punti essenziali della sua riflessione sulla scrittura, come la relazione, reciproca e ineludibile, fra tradizione e contemporaneità. All’epilogo del «romanzo involontario» di una vita, La Capria guarda retrospettivamente alla propria esperienza come ad un’autentica educazione intellettuale. Perciò, muovendo da un’intervista inedita del 2015, riportata integralmente in appendice, la tesi ha l’obiettivo di ricostruire l’apprendistato letterario di La Capria dai primi anni Trenta, quando l’autore ancora frequentava il ginnasio, fino all’inizio dei Sessanta, quando ottenne il premio che ne avrebbe assicurato il successo. Il percorso, che riesamina l’intera bibliografia lacapriana nella sua varietà e nella sua stratificazione, si articola in una serie di fasi interdipendenti: la partecipazione indiretta alle iniziative dei GUF (intorno alle riviste «IX maggio» e «Pattuglia»); l’incursione nel giornalismo e l’impegno culturale nell’immediato dopoguerra (sulle pagine di «Latitudine» e di «SUD»); l’attività di traduttore dal francese e dall’inglese (da André Gide a T.S. Eliot); l’impiego alla RAI come autore e conduttore radiofonico (con trasmissioni dedicate a Orwell, Stevenson, Saroyan e Faulkner); la collaborazione con «Il Gatto Selvatico», la rivista dell’ENI voluta da Enrico Mattei e diretta da Attilio Bertolucci; e le vicende editoriali dei suoi primi due romanzi, “Un giorno d’impazienza” (1952) e “Ferito a morte” (1961), fino alla conquista dello Strega. La rilettura dell’opera di uno scrittore semi-autobiografico come La Capria, attraverso il costante riscontro di fonti giornalistiche, testimonianze epistolari e documenti d’archivio che avvalorano e occasionalmente smentiscono la sua versione dei fatti, diventa allora un’occasione per immergersi nella sua mitografia personale e avventurarsi in territori finora poco esplorati: come la ricostruzione del suo profilo culturale, a partire dal milieu in cui La Capria vive e opera, o l’incidenza delle letture e delle esperienze giovanili sulla sua prassi letteraria.

Книги з теми "Antonio de Curtis":

1

Ambrosino, Gianni, and Aldo De Francesco. Totò sbanca: Conoscere e amare il principe Antonio de Curtis. Napoli: Iuppiter edizioni, 2016.

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2

Totò. Siamo uomini o caporali?: Diario semiserio di Antonio de Curtis. Roma: Newton Compton, 1993.

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3

Melissa Lepre, Rita, Cristiane Paiva Alves, Patrícia Unger Raphael Bataglia, and Antonio Carlos Jesus Zanni de Arruda. Desenvolvimento moral e educação em valores: estudos e pesquisas. Gradus Editora, 2021. http://dx.doi.org/10.46848/978118.

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O livro “Desenvolvimento moral e educação em valores: estudos e pesquisas” constitui-se em um exemplo da produção científica gerada em grupos de estudos e de pesquisa, associados a Programas de Pós-graduação, de duas unidades da Universidade Estadual Paulista (Unesp), quais sejam: a Faculdade de Ciências, câmpus de Bauru, e a Faculdade de Filosofia e Ciências, câmpus de Marília. Esses professores formaram-se em cursos de graduação voltados para o cuidar e para o educar: as professoras Rita Melissa e Patrícia, em Psicologia; a professora Cristiane, em Terapia Ocupacional; e o professor Antonio Carlos, em Filosofia e em Pedagogia. Na formação em pós-graduação, as professoras Rita Melissa e Cristiane, assim como o professor Antonio Carlos, são doutores em Educação, já a professora Patrícia, em Psicologia. Em comum, esses professores/pesquisadores têm a preocupação com a educação sociomoral das pessoas, especialmente crianças e adolescentes que estão na Educação Básica, da Educação Infantil ao Ensino Médio, e a formação de educadores nas licenciaturas, assim como a continuidade dos estudos desses profissionais, quando em serviço.
4

Alcántara Moral, Antonio. Los cantes de laboreo de Torredelcampo. 2021st ed. Editorial Universidad de Sevilla, 2019. http://dx.doi.org/10.12795/9788447222155.

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La obra rescata estos cantes tan significativos y los dignifica como se hizo antaño con algunos palos del flamenco y otras vertientes folclóricas. Unos estilos que Antonio Alcántara ha recuperado y los presenta a la sociedad, para que no se pierdan jamás y pervivan en la memoria colectiva porque un pueblo que da la espalda a su cultura popular corre el riesgo de sumergirse en la ignorancia. El autor bucea en las raíces sociales, penetra en la identidad del pueblo torrecampeño, surca la memoria colectiva para que no se seque esa gran semilla de los cantes de laboreo y se pueda seguir nutriendo la savia de este manojo de estilos venustos y vetustos que aportan muchos frutos a la cultura andaluza. Un patrimonio que se debe seguir labrando con esmero, cultivando con el mismo tesón con el que abrían los surcos esos agricultores curtidos, que regaban con su sudor las gavillas de trigo, unos héroes anónimos a los que Antonio Alcántara rinde un sentido homenaje y merecido reconocimiento con su ímproba labor de restitución histórica y cultural. El DVD incluye 11 cantes de laboreo de Francisco Escudero el Perrete, ganador del XXII Concurso Nacional de Arte Flamenco de Córdoba 2019, así como 20 grabaciones inéditas de agricultores torrecampeños como Francisco Valderrama, uno de los hermanos mayores del gran maestro Juanito Valderrama. Además, contiene un vídeo documental sobre los cantes de laboreo y las tareas agrícolas en los que se desarrollaban.
5

Payne, Michael. Olympic Turnaround. Greenwood Publishing Group. Inc., 2006. http://dx.doi.org/10.5040/9798400692949.

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Higher, faster, stronger… The Olympic motto conjures images of heroes whose achievements transcended their athletic prowess, but also of tragedy and disgrace. By 1980, the modern Olympic movement was gasping for breath, bankrupt financially, politically, and culturally. But under the leadership of Juan Antonio Samaranch, and, subsequently, Jacques Rogge, the Olympics began a journey back from the brink. Michael Payne, who served as the International Olympic Committee’s top marketer for over twenty years, offers unprecedented access to the people and negotiations behind one of the most dramatic turnarounds in business or sports history. Through a multi-pronged strategy, the IOC managed to secure lucrative broadcasting commitments, entice well-heeled corporate sponsors, and parlay the symbolism of the Olympics into a brand for which cities around the world are willing to invest billions of dollars. Packed with previously untold stories from the high-octane world where business, sports, politics, and media meet, Olympic Turnaround is a remarkable tale of organizational renewal and a fascinating glimpse behind the curtain of the world’s most iconic brand. The 2008 Games in Beijing, for example, are expected to involve over 10,000 athletes from 200 countries, draw 20,000 media representatives, and generate over $4 billion in sponsorships and broadcasting rights. Packed with previously untold stories from the high-octane world where business, sports, politics, and media meet, Olympic Turnaround is a remarkable tale of organizational renewal and a fascinating glimpse behind the curtain of the world’s most iconic brand.
6

Pinto, Álvaro Parra. Romances Curtos Em Espanhol Fácil para Iniciantes Com + de 60 Exercícios and Vocabulário de 200 Palavras: O Principezinho de Antoine de Saint-Exupery. Independently Published, 2019.

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7

Melo, Francisco Dênis, and Edvanir Maia da Silveira. Nas trilhas do sertão: escritos de cultura e política do Ceará – volume 7. SertãoCult, 2022. http://dx.doi.org/10.35260/54210157-2022.

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Como será o lugar quando ninguém passa por ele? – pergunta o poeta. Será que “Existem coisas sem ser vistas?” E o mundo, mundo grande, como escreveu, pode existir “apenas pelo olhar que cria e lhe confere espacialidade?” O poeta parece querer nos dizer que “Aquilo que vemos vale – vive – apenas por aquilo que nos olha”, 1 que ver é experimentar ser visto, que ser visto é existir, e ainda que haja uma “cisão que separa dentro de nós o que vemos daquilo que nos olha”, 2 as coisas, os acontecimentos só têm existência na medida mesma de nossa presença, de nossa potência visual, de nosso corpo que toma e encorpa o espaço, o tempo e gera existência e resistência, presença e ausência, o antes e o depois, a perda e a insistência. Duas dimensões importantes de parte significativa da poética de Carlos Drummond de Andrade são a memória e a questão da finitude, que se manifestam em resíduos de memórias e de espaços familiares. A dimensão da finitude, em especial, faz com que o poeta some inúmeras questões em forma de perguntas à sua poética, como lemos na passagem do poema supracitado. Esse dado é importante porque denota a provisoriedade e a fragilidade das respostas possíveis elaboradas no corpo dos próprios poemas. O poeta não tem respostas para todas as perguntas que faz. Os historiadores também não têm respostas para todas as questões que levantam em suas pesquisas, em suas aulas, cursos, intervenções. Por isso, com relação a Drummond, parte de sua poesia é metapoesia. Nesse sentido, somos levados a nos perguntar se a escrita do Historiador não seria meta-história, ou seja, o “estudo referente à história enquanto historiografia; por exemplo, o estudo da linguagem, ou linguagens, da historiografia”? 3 Assim, dessa forma, elaboramos histórias que ajudam na construção de outras histórias? Cada um dos autores desta coletânea conhece o lugar por onde passam, porque sua prática é constituída por um demorar-se em suas temáticas, pela identificação e reflexão sobre problemas e questões, portanto, o desejo é que nada permaneça fora do alcance de sua vista, o que garante para cada um a criação e configuração de certa espacialidade e temporalidade fundamentais com relação às pesquisas abordadas. Evidentemente que demorar-se e conhecer-se, nas temáticas levantadas, não isenta todos, todas e cada um de certa estranheza e inquietação marcadas exatamente pelas respostas impossíveis de serem encontradas, assim é que a familiaridade com a temática não garante, e jamais garantirá, a tranquilidade de um “sentir-se em casa”, o que até certo ponto é bom, na medida em que nos coloca sempre em estado de alerta para o que até então não foi visto, alcançado, sentido como presença em variados tempos e espaços, e que esperam de nós inteligibilidade na busca, a um só tempo, pelo todo e as partes, como assevera Antoine Proust. Portanto, nada é suposto na existência, isso porque, como escreve o poeta, “Ou tudo vige planturosamente, à revelia/ de nossa judicial inquirição / e esta apenas existe consentida/ pelos elementos inquiridos?”, posto que o que vigora na existência, mesmo à revelia de nossa mais cuidadosa inquirição, o que garante as nossas questões, são as próprias questões, e não o que está fora, o que não faz parte das problemáticas levantadas, e é exatamente nessa “espantosa batalha/ entre o ser inventado/e o mundo inventor” que nos colocamos e nos demoramos. Somos “ficção rebelada/ contra a mente universa”, levantando a alvenaria de nosso lugar, de nosso estranho lugar, de nossa morada, lugar de uma certa permanência que nos ampara e nos sacode ao mesmo tempo. Assim, abrimos nossas trilhas em seu sétimo volume. Trilhas são caminhos ou estradas, existentes ou estabelecidos, com dimensões e formas, comprimento e largura diferentes, aptos a aproximar, juntar, estabelecer espaços de interação, indicar, duvidar, marcar, apontar direções, ligar, sinalizar, abrir passagens. Entre as inúmeras trilhas abertas sertões afora e cidades adentro, nós abrimos as nossas, dispomos nossos passos, medimos as dificuldades do terreno e nos lançamos nessa caminhada que já dura tantos anos, deixando fincados nas terras por onde passamos, marcos e marcas, impressões e signos, sinais e símbolos, partes de cada de um nós, como um olhar lançado, que confere e configura tempos e espacialidades. O presente volume divide-se em duas partes, respectivamente: “História, memória, autoritarismo e militância política no século XX” e “Experiências citadinas e sertanejas, oralidade e tradição nos sertões do Ceará nos séculos XIX e XX”. Na primeira parte do livro, abrimos nossos trabalhos com o capítulo de Jucelio Regis da Costa, “Da construção a celebração do golpe de 1964 no Ceará: usos políticos de elementos neomedievalizantes”, que faz uma análise de acontecimentos nacionais da década de 1960, com profundas repercussões no Ceará, como as Cruzadas do Rosário em Família, a Missa congratulatória às Forças Armadas e as Marchas da Vitória, com ampla mobilização política de grupos conservadores do estado, com a finalidade de combater o comunismo, servindo assim “na pavimentação do caminho ao golpe civil-militar de 1964”. O autor elege como objeto central de sua análise elementos neomedievalizantes, quando sentidos positivos foram atribuídos à Idade Média e os acontecimentos em questão foram medievalizados. Edvanir Maia da Silveira, em “Os partidos políticos e a experiência democrática na Zona Norte Cearense (1945-64)”, discute como as décadas de 1945 a 1964 consagraram-se na historiografia como tempo da experiência democrática, em que vigorava uma Constituição, partidos, eleições e participações sociais no debate político, sem, no entanto, descurar do fato de que muitas práticas autoritárias estavam presentes e ativas no cenário político, de modo que essas experiências e conflitos foram vivenciados e ressignificados pelas lideranças da Zona Norte do Ceará. O capítulo assinado por Viviane Prado Bezerra, “‘Quando a mulher sai do mundo da cozinha dela e começa a participar das coisas, então ela começa a ver o mundo diferente’: trabalho pastoral e atuação política das camponesas no Movimento do Dia do Senhor (1970-1990)”, aborda a militância religiosa e política de mulheres camponesas no Movimento do Dia do Senhor, uma iniciativa católica que tinha relação com as Comunidades Eclesiais de Base – CEBs e que teve intensa atuação entre as décadas de 1960 e 1990 alimentada pela dimensão da “fé e vida”, modificando “a visão de mundo e atuação dessas mulheres em suas comunidades”, tornando-as “protagonistas na luta pela libertação, posse da terra e pela igualdade de gênero”. No último capítulo da primeira parte, “Cem anos de comunismo no Brasil: onde Camocim entra nessa história?”, de Carlos Augusto Pereira dos Santos, o autor discute, dentro das comemorações dos cem anos do Partido Comunista do Brasil (PCdoB), agora em 2022, a participação da cidade de Camocim nessa longa história, utilizando como documento uma entrevista realizada com o “Sr. Nilo Cordeiro de Oliveira, comunista histórico em Camocim, filho de Pedro Teixeira de Oliveira (Pedro Rufino), um dos fundadores do Partido Comunista Brasileiro (PCB) em Camocim em 25 de março de 1928”. Voltando à trilha poética aberta por Carlos Drummond de Andrade, tomando o caminho dA suposta existência, pensamos se “A guerra sem mercê, indefinida, prossegue, feita de negação, armas de dúvida […]teima interrogante de saber/ se existe o inimigo, se existimos/ ou somos todos uma hipótese/ de luta/ ao sol do dia curto em que lutamos”, e se a nossa luta se faz e se refaz em cada página escrita, em cada aula debatida, em cada projeto realizado, uma vez que, se a pressa existe, é porque sabemos que um dia é muito curto para quem luta. Por isso a soma de todos nós, a multiplicação de nossas pesquisas, a publicização tão importante de nossas inquietações. Na segunda parte do livro, Francisco Dênis Melo, a partir do capítulo “Sobral e os seus altares: imaginária urbana e heróis civilizadores”, tem como objetivo “pensar a cidade de Sobral-CE a partir de alguns de seus habitantes de pedras, ou melhor, de sua imaginária urbana, no caso bustos, estátuas e monumentos destacados em variados espaços, notadamente em suas praças”, que funcionaram e ainda funcionam como anteparo para os campos políticos e religiosos na cidade, constituindo assim um poderoso mecanismo simbólico de construção do poder em Sobral. Thiago Braga Teles da Rocha, em “‘Sobral como cidade progressista’: entre planos, projetos e representações”, discute o processo de eletrificação em Sobral, estabelecendo uma relação com o conceito de progresso. O texto nos mostra que foi organizada uma “campanha em prol da eletrificação da cidade, realizada por setores da elite política da cidade, com destaque para a Igreja Católica a partir do jornal Correio da Semana”. Para isso, foi utilizado o “Projeto das Redes Primárias e Secundárias de Distribuição de Energia Elétrica da Cidade de Sobral”, documento resguardado no Núcleo de Documentação Histórica (NEDHIS), ligado ao curso de História da Universidade Estadual Vale do Acaraú. O capítulo assinado por Antônio Vitorino Farias Filho, “Imagens no espelho: mulher depravada e mulher ideal em Ipu-CE no início do século XX”, discute a questão da prostituição e sua relação tensa com a chamada Modernidade e com os valores do progresso, de modo que a prostituta no espaço público representou “uma imagem invertida da mulher ideal, buscada pelos grupos dominantes”. Chama atenção o autor para o importante fato de que “É somente no início do século XX, mais ainda na década de 1920, na cidade de Ipu, que a prostituta e a prostituição aparecem explicitamente nas fontes”. No capítulo “‘Isso é atestado de seu progresso. Sí Sobral, Camocim e outras cidades sertanejas têm o seu jornal, porque não poderíamos ter?’ a elite escritora e o ideário de controle e modernidade em Ipu-CE (1900-1920)”, Antonio Iramar Miranda Barros e Alexandre Almeida Barbalho discutem a questão da Modernização sob a ótica das lides jornalísticas, a partir das experiências e do “pensamento de três sujeitos, a partir dos grupos aos quais pertenciam: Abílio Martins, Herculano Rodrigues e Leonardo Mota”, entendendo que os jornais eram encarados como sinais claros de progresso, desenvolvimento e inovação. Raimundo Alves de Araújo e Emmanuel Teófilo Furtado Filho assinam o capítulo “O campo de concentração do Ipu no contexto da Revolução de 1930”. Os autores analisam a constituição do campo de concentração na cidade do Ipu no ano de 1932, no contexto de criação de outros campos, em cidades como Quixeramobim, Crato, Cariús, Senador Pompeu e Fortaleza. Os autores refletem que tal acontecimento não tem o reconhecimento e importância para os poderes locais, lamentando “que não haja um marco histórico identificando o local exato do campo de concentração do Ipu, nem um memorial preservando a memória e a história de tão trágico e lamentável acontecimento!” O campo de concentração da cidade do Ipu fazia parte de um projeto maior, que, entre outros objetivos, pretendia “fazer dele uma ‘parede de contenção’ para poupar a cidade de Sobral do assédio dos retirantes”. Nesse sentido, afirmam os autores que “Ignorar este passado horrível é o mesmo que ‘assassinar novamente’ aquelas vítimas”. Na sequência, Cid Morais Silveira, em “‘Os teus filhos, cidade encantada, escondidos no seu coração’: a vida e a morte do Centro Social Morrinhense (1952 – 1963)”, analisa a criação e o fim de uma instituição chamada Centro Social Morrinhense, em 1952, na cidade de Fortaleza, num contexto em que seus fundadores acreditavam que Morrinhos, “uma pequena vila encravada entre o litoral e o sertão, no interior cearense, composta de oito ruas, dois grandes quadriláteros que os moradores chamavam de ‘praça’ e com aproximadamente 1.097 habitantes”, estava “desamparada e abandonada pelo poder público”, objetivando “1º) proporcionar as melhores ocasiões de progresso àquela vila; 2º) levantar o nível social de seus habitantes; 3º) auxiliar os estudantes pobres do distrito; 4º) promover campanha sobre assuntos dos mais variados: educação, cultura, escolas, alfabetização de adultos, agricultura e outros problemas locais”. Joaquim dos Santos, no capítulo “‘Nas porteiras’ de outros mundos: a Pedra Branca na tradição oral”, encontrou uma pedra em seu caminho. Por isso reflete “sobre o lugar da Pedra Branca na tradição oral sobre os mortos na região do Cariri, dando destaque às memórias sobre a grande rocha e os significados que lhe são atribuídos pelos moradores das áreas próximas ao rochedo”. Aponta o autor que “a Pedra Branca está localizada no sítio Jatobá, na encosta da Chapada do Araripe, zona rural do município de Porteiras”. Ele enfatiza ainda que na “relação entre as pedras e as almas nos interiores do Brasil, é notório como seus laços são estreitos e porosos, tanto no que diz respeito às pedrinhas, quanto aos grandes rochedos”. Fechando a segunda parte e a obra, temos o capítulo de Reginaldo Alves de Araújo, “Vamos falar sobre um sertão? Do sertão dos párias incultos ao culto à pátria”, no qual o autor analisa “algumas variações de sentido da palavra sertão em diferentes momentos históricos”, atentando para o fato de que vai deixar “de lado a ideia de sertão como sinônimo de seca e de fome […] para nos concentrarmos em outras duas imagens: a de um espaço não civilizado no contexto colonial, ao sertão enquanto reservatório das raízes culturais da nacionalidade brasileira”. Entende o autor o sertão como um espaço plural e simbólico, material e sensível, sendo entendido também como um espaço de resistência renhida ao colonialismo. Voltando à trilha aberta por Carlos Drummond, no poema A suposta existência, nos diz o poeta: “[…] e tento construir-me de novo a cada instante, a cada cólica, na faina de traçar meu início […]”. O ser do poeta é parte remontada, refeita, ressignificada com a matéria da vida, com o espanto de todo dia. Ser reconstrução é sonhar ser outro a cada instante, apesar da cólica, do gemido. O que há, de fato, para se construir novo a cada instante, é uma multiplicidade de caminhos, de trilhas, de sendas abertas. O poeta nos mostra novos caminhos, assim como historiadores e historiadoras também apontam em seus trabalhos para o múltiplo das coisas, da vida, dos acontecimentos. E se uma das características da obra poética de Drummond é o “princípio-corrosão”, nas palavras de Luiz Costa Lima, nas obras dos historiadores temos, certamente, o “princípio-reflexão”, quem sabe, de forma mais ousada, o “princípio-coração”… Boa caminhada! Boa leitura! Francisco Dênis Melo

Частини книг з теми "Antonio de Curtis":

1

Badica, Gabriela. "Utopian Discourse and the 2008 Global Financial Crisis: Andrew Ross Sorkin’s and Curtis Hanson’s Too Big to Fail, and Antonio Muñoz Molina’s Todo lo que era sólido." In Performing Utopias in the Contemporary Americas, 193–217. New York: Palgrave Macmillan US, 2017. http://dx.doi.org/10.1057/978-1-137-56873-1_11.

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Gladfelter, Elizabeth Higgins. "Natural Sciences at the Beginning of the Twenty-first Century." In Agassiz’s Legacy, 409–24. Oxford University PressNew York, NY, 2002. http://dx.doi.org/10.1093/oso/9780195154412.003.0007.

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Abstract Are we currently producing the next generation of Agassiz’s heirs? In these pages, we had glimpses of the lives of some of the people who have discovered something new about our natural world, from before World War II to the present. While they have been fortunate to have inherited Agassiz’s legacy themselves, the world has changed in their lifetimes. Curtis Cate, in Antoine de Saint-Exupery: His Life and Times (New York: Putnam, 1970), pointed out, “For it is one of the great (and greatly overlooked) ironies of our age that while the last war [World War II] was fought by the western democracies in the name of liberty and the ‘dignity of the human individual,’ the values which are now everywhere in the ascendant are unindividual, quantitative, and collective” (571).
3

Laing, Sarah. "Short Story." In Katherine Mansfield and Elizabeth von Arnim, 147–58. Edinburgh University Press, 2019. http://dx.doi.org/10.3366/edinburgh/9781474454438.003.0011.

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Laura had been worried all day about crashing the car – the last time she’d driven Monica, she’d overtaken a cyclist on a blind rise and Monica had flinched, anticipating the crunch of a head-on collision that would ricochet the oncoming car against the Frida Kahlo mural on the concrete retaining wall. The mural was primitive, done by a midnight gang with no council mandate. Ian Curtis’s death date was up there too, and either someone continued to touch up the paint, or it had everlasting properties. Why were people in Wellington so fixated on Ian Curtis’s death? Other people had suicided subsequently. Kurt Cobain, Robin Williams, Antony Bourdain. There were no retaining walls near where she lived and the hill crumbled, cascaded, little slumps of ochre rock strewing the road. There was also a sign, warning drivers about low-flying kereru, but the last time she’d biked up the hill, she saw a wood pigeon on the road, its wings iridescent green and blue, scarlet blood starbursting its head. It was the first time she’d seen one with its eyes shut....
4

"The Discovery That Atoms “Fly to Bits”: Becquerel and the Curies (Paris and Warsaw)." In Traveling with the Atom A Scientific Guide to Europe and Beyond, 327–58. The Royal Society of Chemistry, 2019. http://dx.doi.org/10.1039/9781788015288-00327.

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Antoine Becquerel discovered his “rays” while searching for X-rays in fluorescent materials. His potassium uranyl sulfate emitted two types of rays, one being a small stream of particles identical to J. J. Thomson's electrons. We visit places near the Jardin des Plantes where Becquerel's work is celebrated. Next, we follow how the Warsaw-native Maria Salomea Sklodowska earned her way to the Sorbonne in Paris where she excelled, under extraordinarily impoverished conditions, in her study of physics and mathematics. After she married Pierre Curie, they worked together, again under bleak and dangerous conditions, to isolate two new elements, polonium and radium, and coin the term “radioactivity”. Soon afterwards, Pierre died in a tragic traffic accident, but Marie, now the mother of two young daughters, continued their work for twenty more years of both tragedy and triumph. She lived just long enough to see her daughter Iréne, with her husband Frédéric Joliot, discover artificial radioactivity. We visit myriad residences, workplaces, laboratories, hospitals, monuments, statues, museums, and graves all over Paris and Warsaw (and even Brittany) that honor and preserve the memory of the Curies. Three of these are four- or five-atom sites, among the best scientific-historic traveling sites in the world.
5

Villaverde, Cirilo. "X I." In Cecilia Valdés, 88–101. Oxford University PressNew York, NY, 2005. http://dx.doi.org/10.1093/oso/9780195143959.003.0011.

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Abstract When he leapt out of the volante onto the sidewalk, Leonardo thought he noticed that a military officer, in full uniform, who was walking at a fast gait toward the Plaza Vieja, had moved away from the second window of his house, and that at the very same time there had come away from a shutter of that same window the familiar face of one of his sisters. He stepped up his pace and in fact, through another opening in the grating of the zaguán, he saw his elder sister Antonia raising the curtain so as to enter the nearest room through the door that led to the drawing room. This unexpected discovery upset him more than we can imagine because by putting two and two together he convinced himself, beyond a doubt, that while he had been wooing the mulatto girl there in the barrio of El Angel, a Spanish army captain, in the clear light of an October morning, had been courting his sister here in the barrio of San Francisco.
6

Winkler, Kevin. "Double Feature." In Everything is Choreography, 53–70. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190090739.003.0004.

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A Day in Hollywood/A Night in the Ukraine was a tiny jewel box of a musical revue, with a cast of just eight versatile performers, that established Tommy Tune as a director-choreographer of the first rank when it opened in 1980. Its second act was an adaptation of Anton Chekhov’s one-act The Bear as it might have been performed by the Marx Brothers. The trio’s cheerfully anarchic spirit was conjured with balletic grace and timing in Tune’s staging. Tune expanded the show’s curtain raiser, a series of Hollywood songs, into a satiric cavalcade of music and comic musings on the movies circa 1939, set in the lobby of Hollywood’s legendary Grauman’s Chinese Theatre and performed by its ushers. Its highlight was an ingenious tap number set to the text of the 1930 Hollywood Production Code, with all its taboos duly noted in rhythm.

Тези доповідей конференцій з теми "Antonio de Curtis":

1

BOILLAT, GUY, and AUGUSTO MURACCHINI. "ISOCLINE CURVES AND VARIATIONAL SCALAR FIELD." In In Honor of the 65th Birthday of Antonio Greco. WORLD SCIENTIFIC, 2007. http://dx.doi.org/10.1142/9789812708908_0003.

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2

Msika, Rebecca, Magalie Robilliard, Alain Fourquet, Baptiste Porte, and Youlia Kirova. "Abstract P4-12-23: Institut Curie guidelines on breast target volume delineation for patients treated in lateral position." In Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.sabcs19-p4-12-23.

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3

Rivetti, Lara Cristina Casares. "A esfera social no trabalho da arte: relações entre forma e contexto político na obra de Antônio Dias." In Encontro da História da Arte. Universidade Estadual de Campinas, 2018. http://dx.doi.org/10.20396/eha.13.2018.4491.

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Existe um conjunto de trabalhos de Antonio Dias (1944 - 2018), produzido entre cerca de 1963 e 1966, que ocupa um lugar central na sua trajetória. Dias começou a produzir muito cedo, já no final da década de 1950, quando frequentou, como aluno especial, a Escola Nacional de Belas Artes (onde teve aulas com o gravurista Oswaldo Goeldi, do qual foi assistente) e os cursos ministrados por Ivan Serpa e Aluísio Carvão, na escola de artes do Museu de Arte Moderna do Rio de Janeiro / MAM-RJ. É verdade que esses trabalhos inaugurais são ainda incipientes, tateantes e pouco representativos de aspectos que viriam a se revelar como centrais em sua obra. Mas logo nos primeiros anos da década seguinte, surgiu uma produção que demonstrava fôlego para responder às questões colocadas para os artistas naquele momento, e na qual já se encontravam formuladas, com maior contundência, algumas das reflexões que, mais tarde, seriam tomadas como pontos centrais de toda a sua obra.
4

Hequet, Delphine, Louise Maumy, Celine Callens, David Gentien, Ivan Bieche, Paul Cottu, Jean-Marc Guinebretiere, Anne Vincent-Salomon, Florence Lerebours, and Roman Rouzier. "Abstract P2-08-21: Outcomes results of Prosigna® test in early breast cancer patients: Experience of Institut Curie, France." In Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.sabcs19-p2-08-21.

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Slembrouck, L., C. Laurent, LJ Delahaye, L. Mittempergher, I. Vanden Bempt, S. Vander Borght, L. Darrigues, et al. "Abstract P4-08-25: Decentralized beta testing of MammaPrint and BluePrint NGS kit at University Hospitals Leuven and Curie Institute Paris." In Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p4-08-25.

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6

Sebbagh, S., M. Cosquer, YM Kirova, and A. Livartowski. "Abstract P4-13-14: Lung cancer after treatment of breast cancer:retrospective study from Curie Institut." In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p4-13-14.

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Hamy-Petit, A.-S., A. Toussaint, C. Sautter, F. Coussy, A. Donnadieu, R. Rouzier, C. Saule, et al. "Abstract P6-16-02: Fertility preservation in young breast cancer patients: Real life data on 1390 patients treated in the Institut Curie." In Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p6-16-02.

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8

Cottu, PH, MJ Rodrigues, Y. Kirova, and A. Vincent-Salomon. "Treatment of infra-centimetric HER2-positive(+) invasive breast tumors. The Institut Curie experience." In CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.sabcs-3152.

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Vincent, Laura, Clémentine Jankowski, Marion Cortet, Laurent Arnould, Sylvain Ladoire, Bruno Coudert, Isabelle Desmoulins, et al. "Abstract P2-16-14: HER2-positive breast cancer: Combined18F-FDG PET and CGFL/Curie nomogram to predict pathologic complete response after preoperative chemotherapy with trastuzumab." In Abstracts: 2019 San Antonio Breast Cancer Symposium; December 10-14, 2019; San Antonio, Texas. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.sabcs19-p2-16-14.

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Kaczmarek, E., C. Saint-Martin, J.-Y. Pierga, E. Brain, R. Rouzier, C. Dubot, A. Savignoni, et al. "Abstract P5-21-14: Long-term survival in HER2-positive metastatic breast cancer treated with first-line trastuzumab: Real-life results from the Curie ESME database." In Abstracts: 2017 San Antonio Breast Cancer Symposium; December 5-9, 2017; San Antonio, Texas. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.sabcs17-p5-21-14.

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