Дисертації з теми "Antiviraux – Conception"
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Note, Reine. "Conception, synthèse et évaluation d'inhibiteurs mixtes de la transcriptase inverse du VIH." Paris 5, 2000. http://www.theses.fr/2000PA05P606.
Повний текст джерелаBarral, Karine. "Conception, modélisation, synthèse et évaluation des propriétés antivirales de nouveaux analogues de nucléosides." Aix-Marseille 2, 2003. http://www.theses.fr/2003AIX22075.
Повний текст джерелаLefebvre, Isabelle. "Essai de rationalisation dans la conception de pronucléotides à visée anti-VIH." Montpellier 2, 1994. http://www.theses.fr/1994MON20252.
Повний текст джерелаGaleotti, Nathalie. "Conception et synthèse de mimes peptidiques analogues de substrats de la protéase du VIH." Montpellier 2, 1993. http://www.theses.fr/1993MON20002.
Повний текст джерелаMalnuit, Vincent. "Conception, synthèse et étude de nouveaux analogues de nucléosides : application dans le domaine des antiviraux et antitumoraux." Nice, 2011. http://www.theses.fr/2011NICE4001.
Повний текст джерелаDespite significant progress made in recent years, the fight against viral infections and cancer remains a global health problem. This brief summary underlines the need for new compounds in order to overcome the limits of the drugs currently available. Therefore, there is a significant need to develop new methodologies for the synthesis of new bioactive molecules, and new analytical tools for the study of the involved drug/biological target interactions. To this end, the main objective of this thesis is to address these issues following the investigation of three major themes. We first developed a strategy for the synthesis of 1,2,3-triazolyl-nucleosides substituted at positions 4 and 5, using a tandem click/electrophilic addition reaction. Biological tests showed strong anticancer activity against CML for these compounds. We then developed a strategy for post-synthetic modification of oligonucleotides by click chemistry. This reaction allows post-synthetic transformation of oligonucleotides bearing an azide group in a site-specific manner. Therefore, this strategy has a great potential in various applications such as specific labelling of nucleic acids. Finally, we designed a new family of HIV-1 TAR RNA ligands that selectively bind to secondary structures such as stem-loop or stem-bulge, through a cooperative action of several recognition patterns. Among them, we used a modified nucleobase that can specifically recognize an AU base pair. Meanwhile, a new method of screening for this type of base triplets by mass spectrometry is being investigated
Druillennec-Rodière, Sabine. "Démonstration d'une interaction directe entre la protéine de nucléocapside NCp7 et la transcriptase inverse de VIH-1 : caractérisation et inhibition. Conception de nucléo- et peptidomimétiques susceptibles d'inhiber les activités de la NCp7." Paris 5, 1999. http://www.theses.fr/1999PA05P606.
Повний текст джерелаToulouze, Bénédicte. "Sida : revue des obstacles à la mise au point d'un vaccin anti-VIH." Bordeaux 2, 1996. http://www.theses.fr/1996BOR2P060.
Повний текст джерелаCallendret, Benoît. "Conception et évaluation de différentes approches vaccinales contre le coronavirus associé au syndrome respiratoire aigu sévère." Paris 7, 2006. http://www.theses.fr/2006PA077222.
Повний текст джерелаSevere acute respiratory syndrome associated coronavirus (SARS-CoV) emerged in late 2002 and caused an epidemic of atypic pneumonia in humans. Here, we describe three vaccine candidates designed to induce neutralizing antibodies against the viral S glycoprotein, which are the main effectors of the protective immune response. We demonstrated that efficient expression of S gene in mammalian cell lines required the use of optimized vectors containing an intron and post-transcriptional regulatory elements such as WPRE and CTE. Upon immunization of mice with low doses of naked DNA, only intron and WPRE-containing vectors were able to provide protection against challenge with SARS-CoV. We also established stable cell lines constitutively secreting a soluble form of the S protein (Ssol). The immunogenicity of purified Ssol was studied in mouse and hamster models. Two injections of the Ssol polypeptide adjuvanted with Alum induced a strong and long-lasting Th2 immune response comprising high levels of SARS-CoV-neutralizing antibodies. Upon intranasal challenge with SARS-CoV, virus replication was strongly reduced in the lungs of immunized animals and hamsters were protected from the occurrence of lesions in the respiratory tract. Moreover, the use of two new adjuvants developed by GlaxoSmithKline Biologicals further increased the anti-S humoral response and the Thl component of the immune response. Concurrently, we developed HIV-based lentiviral vectors expressing the full-length S protein as an alternate SARS vaccine candidate. In the hamster model, a single injection of these vectors induced a neutralizing antibody response similar to that induced by two injections of Ssol
Abuduaini, Tuniyazi. "Génération de nouveaux acyclonucléosides phosphonates oléfiniques et 1-C-arylglycosides." Electronic Thesis or Diss., Orléans, 2021. http://www.theses.fr/2021ORLE3200.
Повний текст джерелаNucleosides and their analogues constitute the main family of antivirals and anticancer drugs. They provide an extremely powerful tool in effectively combating viral infections associated with many viruses such as HIV, HBV, HCV, CMV, VZV and HSV; they have been at the center of antiviral therapy for more than half a century with around 40 compounds approved by the FDA. Viral infections still represent a large public health problem due to the emergence of new viruses, the appearance of resistance to current antivirals and phenomena of viral mutations. This is why the design and synthesis of new antivirals are still relevant today. In the first part of this manuscript, in order to develop new, more active and safe antivirals, we firstly designed and synthesized two new families of olefinic acyclonucleosides phosphonates under prodrug form by modifying the nucleobase, the acyclic chain and the biolabile group. To do this, we used the cross-metathesis reaction as the key step. In the second part, the "scope" of Migita-Kosugi-Stille cross couplings was explored using stannylated iminoalditols and a small library of variously substituted aroyl chloride. More interestingly, the process of formation of the C‒C bond is stereoretentive. New analogs of C‒glycosylated N‒acetylglucosamine were then prepared by a reaction sequence of reduction, deprotection, mesylation and cyclization
Phelip, Capucine. "Conception, caractérisation et évaluation in vivo d'un vaccin nanoparticulaire anti-VIH et optimisation de sa biodisponibilité par un hydrogel thermosensible." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1280.
Повний текст джерелаCurrent knowledge indicates the need to induce a broad-spectrum immune response including multifunctional antibodies to protect against HIV infection. As traditional vaccine approaches are not capable of inducing potent broad-spectrum neutralizing antibodies (bNAbs) against HIV-1, alternative strategies are being investigated to induce these bnAbs. Major advances include the development of (i) optimized envelope glycoproteins as immunogens, (ii) efficiently carrying and immunogenic carriers, and (iii) the dosage form that would increase the durability of the protective response. In this context, the objective of this PhD is to evaluate the immune responses induced by biodegradable nanoparticles functionalized with HIV envelope glycoproteins and to optimize the in vivo sustained release of the immunogen.First, we compared several glycoproteins and selected an optimized primary isolate glycoprotein (SOSIP BG505) for its ability to be adsorbed to the surface of biodegradable nanoparticles, while exposing neutralization epitopes, and capable of inducing a systemic immune response in vivo. We then designed a thermosensitive, poloxamers-based hydrogel, capable of incorporating these nanoparticles while maintaining their colloidal stability and we have analyzed their biodistribution by whole-body imaging in mice. The subcutaneous injection of this hydrogel makes it possible to induce a strong, stable humoral immune response with high affinity IgGs. This new formulation, innovative and easy to implement, appears as a new vaccination strategy applicable to many viral diseases requiring the induction of high affinity neutralizing antibodies and broad spectrum
Robert, Alain. "Systèmes d'expression bactériens de protéines recombinantes appliqués à la production d'antigènes du virus respiratoire syncytial." Montpellier 2, 1992. http://www.theses.fr/1992MON20184.
Повний текст джерелаLabaille, Jennifer. "Conception d'un vaccin recombinant contre la maladie de Marek d'après l'étude de la dynamique des populations de variants du vaccin CV1988/RISPENS." Thesis, Tours, 2013. http://www.theses.fr/2013TOUR4014.
Повний текст джерелаGallid herpesvirus 2 (GaHV-2), responsible for T-cell lymphomas chicken, is controlled by the vaccine CVI988/Rispens. My work has shown that the vaccine contains, unlike virulent strain, a viral variants population mostly deleted from the promoter region and a variable portion of the 5' end of the gene LAT encoding microRNA and associated with viral latency. In a vaccine approach, a recombinant virus corresponding to a majority variant of the CVI988/Rispens vaccine was generated from a hypervirulent strain GaHV-2, cloned as bacmid. We showed that recombinant, with an almost total loss of pathogenicity, was able to significantly protect chickens against challenge with virulent strains GaHV-2. This work lays the basis for the development of new vaccines from emerging virulent strains
Herzog, Cédric. "Etude des malware évasifs : conception, protection et détection." Electronic Thesis or Diss., CentraleSupélec, 2022. http://www.theses.fr/2022CSUP0001.
Повний текст джерелаThere is a permanent confrontation between malware and antiviruses, leading both parties to evolve continuously. On the one hand, the antiviruses put in place solutions that are more and more advanced and propose complex detection techniques in addition to the classic signature detection. Once a new malware is detected, the antiviruses conduct deeper analysis to extract a signature and keep their database quickly updated. This complexification leads the antiviruses to leave traces of their presence on the machine they protect. On the other hand, malware authors willing to create long- lasting malware at a low cost can use simple techniques to avoid being deeply analyzed by these antiviruses. It is then possible for malware to search for the presence of traces or artifacts left by the antiviruses and then decide to execute or not their malicious payload. We define such software as being evasive malware. This thesis focuses on the study of evasive malware targeting the Windows operating system. A first contribution aims at evaluating the efficiency of evasion techniques against a panel of antiviruses. We then propose a countermeasure designed to stop the execution of the malware using this kind of technique by simulating the presence of the modifications made by the antiviruses within the operating system. These decoys are created by instrumenting the Windows API using Microsoft Detours. Finally, we evaluate this countermeasure on a few samples of malware collected in the wild. A second contribution aims at answering to the lack of a dataset of evasive malware. To do so, we label an existing dataset of Windows malware using two ways. First, with the help of an automatic detection that exploits the countermeasure we created, and second, thanks to collaborative labeling available on a public platform
Borello, Jean-Marie. "Étude du métamorphisme viral : modélisation, conception et détection." Phd thesis, Université Rennes 1, 2011. http://tel.archives-ouvertes.fr/tel-00660274.
Повний текст джерелаPriem, Ghislaine. "Conception, synthèse chimique, évaluation antivirale de nouveaux inhibiteurs du VIH de structure pseudo-peptidique : Etude du greffage sur la matrice k-carraghénane des lipogélosomes." Aix-Marseille 2, 2000. http://www.theses.fr/2000AIX22099.
Повний текст джерелаRocheblave, Luc. "Conception, synthèse et évaluation antivirale de nouveaux dérivés pseudopeptidiques, inhibiteurs de la protéase du VIH-1, contenant le motif (2-phenylsulfanyl-1-hydroxyethyl) sulfonamide." Aix-Marseille 2, 2000. http://www.theses.fr/2000AIX22079.
Повний текст джерелаCoussot, Gaëlle. "Etude de la biotransformation de pronucléotides à visée antivirale par couplage LC-MS et électrophorèse capillaire ; Conception d'une méthode d'extraction "on-line" appliquée à une drogue anticancéreuse : la 5-fluorouracile." Montpellier 2, 2003. http://www.theses.fr/2003MON20090.
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