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Готові списки джерел за темами / Antiproliferative activities / Статті в журналах

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Статті в журналах з теми "Antiproliferative activities"

Автор: Grafiati

Опубліковано: 22 листопада 2023

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1

Zhou, Lin, Xiaohui Lin, Arshad Mehmood Abbasi, and Bisheng Zheng. "Phytochemical Contents and Antioxidant and Antiproliferative Activities of Selected Black and White Sesame Seeds." BioMed Research International 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/8495630.

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Анотація:

Sesame (Sesamum indicumL.) seeds are popular nutritional food but with limited knowledge about their antioxidant and antiproliferative activities of various varieties. Phytochemical profiles and antioxidant and antiproliferative activities of six varieties of sesame (Sesamum indicumL.) seeds were studied.Fenheizhi3(black) cultivar exhibited the maximum contents of total phenolics and lignans and values of total oxygen radical absorbance capacity (ORAC) and antiproliferative activity (EC50) against HepG2 cells. Bound ORAC values showed strong associations with bound phenolics contents (r=0.976,p<0.01); in bound phenolic extracts, EC50values showed strong negative associations with phenolic contents (r=-0.869,p<0.05) and ORAC values (r=-0.918,p<0.01). Moreover, the contents of free phenolics were higher than that of the bound phenolics, and the three black sesame seeds generally depicted higher total phenolics compared to the three white varieties. The antioxidant (ORAC values) and antiproliferation activities of six sesame seeds were both associated with contents of bound phenolics (r>0.8,p<0.05). Interestingly, nonlignan components in bound phenolics contributed to the antioxidant and antiproliferative activities. This study suggested thatFenheizhi3variety is superior to the other five varieties as antioxidant supplements.

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2

Liu, Ming, Xin Qi Li, Courtney Weber, Chang Yong Lee, Janice Brown, and Rui Hai Liu. "Antioxidant and Antiproliferative Activities of Raspberries." Journal of Agricultural and Food Chemistry 50, no. 10 (May 2002): 2926–30. http://dx.doi.org/10.1021/jf0111209.

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3

Xu, XiXi, Tristan Rawling, Ariane Roseblade, Roger Bishop, and Alison T. Ung. "Antiproliferative activities of alkaloid-like compounds." MedChemComm 8, no. 11 (2017): 2105–14. http://dx.doi.org/10.1039/c7md00435d.

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4

Meyers, Katherine J., Christopher B. Watkins, Marvin P. Pritts, and Rui Hai Liu. "Antioxidant and Antiproliferative Activities of Strawberries." Journal of Agricultural and Food Chemistry 51, no. 23 (November 2003): 6887–92. http://dx.doi.org/10.1021/jf034506n.

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5

Huang, Hung-Tse, Chia-Ching Liaw, Yu-Chi Lin, Geng-You Liao, Chih-Hua Chao, Chun-Tang Chiou, Yao-Haur Kuo, and Kung-Ta Lee. "New Diterpenoids from Mesona procumbens with Antiproliferative Activities Modulate Cell Cycle Arrest and Apoptosis in Human Leukemia Cancer Cells." Pharmaceuticals 14, no. 11 (October 29, 2021): 1108. http://dx.doi.org/10.3390/ph14111108.

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Mesona procumbens is a popular material used in foods and herbal medicines in Asia for clearing heat and resolving toxins. However, phytochemical research on this plant is very rare. In this study, eleven new diterpenoids, mesonols A-K (1–11), comprising seven ent-kauranes, three ent-atisanes, and one sarcopetalane, were isolated from its methanolic extract. Structural elucidation of compounds 1–11 was performed by spectroscopic methods, especially 2D NMR, HRESIMS, and X-ray crystallographic analysis. All isolates were assessed for their antiproliferative activity, and compounds 1–4 showed potential antiproliferative activities against A549, Hep-3B, PC-3, HT29, and U937 cancer cells, with IC50 values ranging from 1.97 to 19.86 µM. The most active compounds, 1 and 2, were selected for further investigation of their effects on cell cycle progression, apoptosis, and ROS generation in U937 human leukemia cancer cells. Interestingly, it was found that compounds 1 and 2 induced antiproliferative effects in U937 cells through different mechanisms. Compound 1 caused cell cycle arrest at the G2/M phase and subsequent cell death in a dose- and time-dependent manner. However, 2-mediated antiproliferation of U937 cells triggered ROS-mediated mitochondrial-dependent apoptosis. These results provide insight into the molecular mechanism involved in the antiproliferative activities of compounds 1 and 2 in U937 cells. Altogether, the study showed that new diterpenoid compounds 1 and 2 from M. procumbens are potent and promising anticancer agents.

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6

Zhou, Mingming, Pei Chen, Yuan Lin, Shengzuo Fang, and Xulan Shang. "A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves." Forests 10, no. 8 (July 26, 2019): 625. http://dx.doi.org/10.3390/f10080625.

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Cyclocarya paliurus (Batal.) Iljinskaja is an indigenous and multifunction tree species in China, but it is mainly used in pharmaceutical and nutraceutical ingredients. To make a comprehensive evaluation on its bioactive metabolites, antioxidant and antitumor potentials of C. paliurus leaves, the leaf samples were collected from 15 geographic locations (natural populations) throughout its distribution areas. High-performance liquid chromatography (HPLC) and colorimetric methods were used to detect the contents of bioactive metabolites. The antioxidant activity was evaluated by 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and reducing power assays. The antiproliferative activity on different cancer cell types was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Contents of bioactive metabolites, and antioxidant and antiproliferative activities in the extracts were significantly affected by solvent and population. In most cases, the contents of flavonoids and triterpenoids, and the antioxidant and antiproliferative activities in the ethanol extracts were higher than the water extracts. The best scavenging capacity of DPPH (IC50 = 0.34 mg/mL) and ABTS (IC50 = 0.50 mg/mL) radical occurred in the ethanol extracts of S15 and S7 population respectively, while the strongest reducing power (EC50 = 0.71 mg/mL) was achieved in the ethanol extracts of S14 population. The antiproliferation effects of C. paliurus extracts on cancer cells varied with different cell types. The HeLa cell was the most sensitive to C. paliurus extracts, and their IC50 values of the ethanol extracts varied from 0.13 to 0.42 mg/mL among C. paliurus populations. Redundancy analysis showed that total polyphenol had the greatest contribution to the antioxidant activity, but total flavonoid was mostly responsible for the antiproliferation effects. These results would provide important scientific evidences not only for developing C. paliurus as a potent antioxidant and antitumor reagent, but also for obtaining the higher yield of bioactive compounds in the C. paliurus plantation.

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7

Chang, Tien-Ning, Guan-Jhong Huang, Yu-Lin Ho, Shyh-Shyun Huang, Heng-Yuan Chang, and Yuan-Shiun Chang. "Antioxidant and Antiproliferative Activities of Crossostephium chinensis (L.) Makino." American Journal of Chinese Medicine 37, no. 04 (January 2009): 797–814. http://dx.doi.org/10.1142/s0192415x09007259.

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Crossostephium chinensis (L.) (CC) Makino is a common traditional Chinese medicinal plant used to dehumidify and cure rheumatism and arthralgia. The water and methanol extracts of C. chinensis (CCW and CCM) were evaluated for their antioxidant and antiproliferative activities. The antioxidant activities of CC were evaluated by using ABTS radical scavenging, DPPH radical scavenging, nitric oxide scavenging and superoxide scavenging methods. Iron chelating activity, lipid peroxidation, total polyphenol contents, total flavonoid contents and total flavonol contents were also detected. In all the tested models, both CCW and CCM showed their ability to scavenge the free radicals in a does-dependent manner. CCW had higher antioxidant and antiproliferative activities than CCM. In LC-MS-MS analysis, the chromatograms of CCW with good antioxidant activities were established. Rutin might be an important bioactive compound in CCW. The antiproliferative activities of CCW and CCM were also studied in vitro by using human hepatoma HepG2 cells. CCW exhibited good antiproliferative activity. These results indicated that CCW might be used as a potential source of natural antioxidants and as an anti-tumor agent.

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8

Vollár, Martin, András Gyovai, Péter Szűcs, István Zupkó, Marianna Marschall, Boglárka Csupor-Löffler, Péter Bérdi, et al. "Antiproliferative and Antimicrobial Activities of Selected Bryophytes." Molecules 23, no. 7 (June 23, 2018): 1520. http://dx.doi.org/10.3390/molecules23071520.

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9

Negi, Arvind Singh, Suaib Luqman, Suchita Srivastava, Vinay Krishna, Namita Gupta, and Mahendra Pandurang Darokar. "Antiproliferative and antioxidant activities ofJuglans regiafruit extracts." Pharmaceutical Biology 49, no. 6 (May 9, 2011): 669–73. http://dx.doi.org/10.3109/13880209.2010.537666.

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10

B. Ng, T., and J. H. Wong. "Fungal Proteins with Antiproliferative and Anticancer Activities." Protein & Peptide Letters 20, no. 4 (February 1, 2013): 433–38. http://dx.doi.org/10.2174/092986613805290363.

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11

B. Ng, T., and J. H. Wong. "Fungal Proteins with Antiproliferative and Anticancer Activities." Protein & Peptide Letters 20, no. 4 (February 18, 2013): 433–38. http://dx.doi.org/10.2174/0929866511320040007.

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12

Matousek, Josef. "Ribonucleases, Nucleases and Antiangiogenins in Antiproliferative Activities." Current Signal Transduction Therapy 6, no. 3 (September 1, 2011): 363–82. http://dx.doi.org/10.2174/157436211797483921.

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13

Chu, Yi-Fang, Jie Sun, Xianzhong Wu, and Rui Hai Liu. "Antioxidant and Antiproliferative Activities of Common Vegetables." Journal of Agricultural and Food Chemistry 50, no. 23 (November 2002): 6910–16. http://dx.doi.org/10.1021/jf020665f.

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14

Sun, Jie, Yi-Fang Chu, Xianzhong Wu, and Rui Hai Liu. "Antioxidant and Antiproliferative Activities of Common Fruits." Journal of Agricultural and Food Chemistry 50, no. 25 (December 2002): 7449–54. http://dx.doi.org/10.1021/jf0207530.

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15

Loizzo, Monica Rosa, Morteza Abouali, Peyman Salehi, Ali Sonboli, Mohammad Kanani, Francesco Menichini, and Rosa Tundis. "In vitroantioxidant and antiproliferative activities of nineSalviaspecies." Natural Product Research 28, no. 24 (July 21, 2014): 2278–85. http://dx.doi.org/10.1080/14786419.2014.939086.

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16

Li, Fang, Sha Li, Hua-Bin Li, Gui-Fang Deng, Wen-Hua Ling, and Xiang-Rong Xu. "Antiproliferative activities of tea and herbal infusions." Food & Function 4, no. 4 (2013): 530. http://dx.doi.org/10.1039/c2fo30252g.

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17

Wu, Li-chen, Hsiu-Wen Hsu, Yun-Chen Chen, Chih-Chung Chiu, Yu-In Lin, and Ja-an Annie Ho. "Antioxidant and antiproliferative activities of red pitaya." Food Chemistry 95, no. 2 (March 2006): 319–27. http://dx.doi.org/10.1016/j.foodchem.2005.01.002.

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18

Marques, Beatriz C., Mariana B. Santos, Daiane B. Anselmo, Diego A. Monteiro, Eleni Gomes, Marilia F. C. Saiki, Paula Rahal, Pedro L. Rosalen, Janaina C. O. Sardi, and Luis O. Regasini. "Methoxychalcones: Effect of Methoxyl Group on the Antifungal, Antibacterial and Antiproliferative Activities." Medicinal Chemistry 16, no. 7 (November 6, 2020): 881–91. http://dx.doi.org/10.2174/1573406415666190724145158.

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Background: Chalcones substituted by methoxyl groups have presented a broad spectrum of bioactivities, including antifungal, antibacterial and antiproliferative effects. However, a clear and unambiguous investigation about the relevance of this substituent on the chalcone framework has not been described. Objective: The purpose of this work is to assess the antibacterial, antifungal and antiproliferative activities of the two series of seventeen synthesized regioisomeric methoxychalcones. Series I and II were constituted by chalcones substituted by methoxyl groups on rings A (5–12) and B (13–21), respectively. In addition, the library of methoxychalcones was submitted to in silico drug-likeness and pharmacokinetics properties predictions. Methods: Methoxychalcones were synthesized and their structures were confirmed by NMR spectral data analyses. Evaluations of antimicrobial activity were performed against five species of Candida, two Gram-negative and five Gram-positive species. For antiproliferative activity, methoxychalcones were evaluated against four human tumorigenic cell lines, as well as human non-tumorigenic keratinocytes. Drug-likeness and pharmacokinetics properties were predicted using Molinspiration and PreADMET toolkits. Results: In general, chalcones of series I are the most potent antifungal, antibacterial and antiproliferative agents. 3’, 4’, 5’-Trimethoxychalcone (12) demonstrated potent antifungal activity against Candida krusei (MIC = 3.9 μg/mL), eight times more potent than fluconazole (reference antifungal drug). 3’-Methoxychalcone (6) displayed anti-Pseudomonas activity (MIC = 7.8 μg/mL). 2’,5’-Dimethoxychalcone (9) displayed potent antiproliferative effect against C-33A (cervix), A-431 (skin) and MCF-7 (breast), with IC50 values ranging from 7.7 to 9.2 μM. Its potency was superior to curcumin (reference antiproliferative compound), which exhibited IC50 values ranging from 10.4 to 19.0 μM. Conclusion: Our studies corroborated the relevance of methoxychalcones as antifungal, antibacterial and antiproliferative agents. In addition, we elucidated influence of the position and number of methoxyl groups toward bioactivity. In silico predictions indicated good drug-likeness and pharmacokinetics properties to the library of methoxychalcones.

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19

Isnaini, Isnaini, Rosinta Dewi Achmadiyah, Gelvia Awaeh, Husnul Khatimah, and Alfi Yasmina. "Antioxidant and Antiproliferative Activities of Methanol Extract from Melaleuca cajuputi subsp. Cumingiana [Turcz.] Fruit." Jurnal Berkala Ilmiah Sains dan Terapan Kimia 17, no. 1 (February 14, 2023): 21. http://dx.doi.org/10.20527/jstk.v17i1.13055.

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Melaleuca cajuputi subsp. Cumingiana [Turcz.] Barlow (M. cajuputi) is a plant that is easily found in Banjarmasin. M. cajuputi contains phytochemical compounds in the form of polyphenols including flavonoids, quinons, saponins, and alkaloids that are thought to have antioxidant and antiproliferation activities. The aim of this research was to find out analyze antioxidant and antiproliferation activity of M. cajuputi fruit methanol extract. The antioxidant activity was tested using the DPPH method. The activities were observed in IC50 and were measured using the UV-VIS spectrophotometer at a wavelength of 517 nm. To test the antiproliferation, true experimental with post-test was applied in this research. Animal used in this study were 30 mature zebras (length > 2.5 cm) which were grouped into 4, namely the negative control group (DMSO 0.05%), the methanol extract group of M. cajuputi with concentrations of 18.5 ppm, 37 ppm and 74 ppm. The bound variable in this study was antiproliferation activity in the tail of an amputated fish. Data analysis was measured by one-way ANOVA and Post-Hoc Tukey HSD tests. Phytochemical results obtained the presence of phenol compounds, cuinons, flavonoids, alkaloids, saponins, tannins, steroids and terpenoids. Methanol extract of Melaleuca cajuputi subsp Cumingiana [Turcz.] Barlow fruit was at IC50 of 15.50 ppm (95% CI 8.31- 32.72). The antiproliferation activity of zebrafish tails increased in the administration of fruit extract Melaleuca cajuputi subsp. Cumingiana [Turcz.] Barlow in consentration of 74 ppm (p<0.05), both on day 4 and day 8 of measurement when compared to negative controls. It can be concluded that methanol extract of Melaleuca cajuputi subsp Cumingiana [Turcz.] Barlow fruit has antiproliferative activity against the growth of amputated zebrafish tails.

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20

Liu, Chia-Yu, Ying-Chih Lin, Jeng-Shyan Deng, Jung-Chun Liao, Wen-Huang Peng, and Guan-Jhong Huang. "Antioxidant, Anti-inflammatory, and Antiproliferative Activities of Taxillus sutchuenensis." American Journal of Chinese Medicine 40, no. 02 (January 2012): 335–48. http://dx.doi.org/10.1142/s0192415x12500267.

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Inflammation is related to several chronic diseases, including cancer and atherosclerosis. Taxillus sutchuenensis (Lecomte) Danser is a special folk medicinal plant in Taiwan. The aim of this study was to evaluate the antioxidant, anti-inflammatory, and antiproliferative activities of the aqueouse-thanol extract from T. sutchuenensis (AETS) and its fractions. TEAC, DPPH radicals, total phenolic compounds, total flavonoid content, inhibition of NO production in LPS-induced RAW264.7 cells, and inhibition of cancer cell proliferation were tested. Among all fractions, the ethyl-acetate (EA) fraction showed the highest TEAC and DPPH radical scavenging activities. The EA fraction also had the highest polyphenol and flavonoid content. The EA fractions also decreased LPS-induced NO production and the expression of iNOS and COX-2 in RAW264.7 cells. The antiproliferative activities of the aqueous/ethanol extract and fractions were studied in vitro using A549 cells, and the results were consistent with their antioxidant capacities. EA fractions had the highest antiproliferative activity with an IC50 of 454.38 ± 1.48 μg/ml. Quercetin also had antioxidant, anti-inflammatory, and antiproliferative activities. Quercetin might be an important bioactive compound in T. sutchuenensis. The experimental data indicated that T. sutchuenensis is a potent antioxidant medicinal plant, and such efficacy may be mainly attributed to its polyphenolic compounds.

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21

Ran, Li-qiong, Xue-li Li, Man-hui Liu, and Qiu-an Wang. "Synthesis and antiproliferative activities of polymethoxyflavones aminoalkyl and amino acid derivatives." Heterocyclic Communications 26, no. 1 (April 28, 2020): 68–75. http://dx.doi.org/10.1515/hc-2020-0010.

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AbstractTwelve novel aminoalkyl derivatives 3a-3f, 4a-4f and four novel amino acid derivatives 5a, 5b, 6a and 6b of polymethoxyflavones 1 and 2 were synthesized through regioselective demethylation, etherification, amination, EDCl-mediated amide condensation and alkaline hydrolysis, using tangeretin and nobiletin as starting materials. Their antiproliferative activities against four different human cancer cell lines (Aspc-1, SUN5, HepG-2 and HCT116) were evaluated by in vitro CCK-8 assay. The results show that the majority of the synthetic compounds exhibited moderate to good antiproliferative activity. In particular, the antiproliferative activity of compound 5b against HepG-2 cells (IC50 0.057 μM) was equal to the positive control drug Staurosporine (IC50 0.0575 μM).

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22

Pakalapati, Swarnalatha, Ganesh babu Devara, and Anitha Mamillapalli. "Antioxidant, antiproliferative and antimicrobial activities study of Zingiber roseum rosc., an endangered medicinal plant." International Journal of Scientific Research 2, no. 7 (June 1, 2012): 25–30. http://dx.doi.org/10.15373/22778179/july2013/10.

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23

Hu, Xu, Dahong Li, Chun Chu, Xu Li, Xianhua Wang, Ying Jia, Huiming Hua, and Fanxing Xu. "Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives." International Journal of Molecular Sciences 19, no. 11 (October 30, 2018): 3403. http://dx.doi.org/10.3390/ijms19113403.

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Alkaloids, a category of natural products with ring structures and nitrogen atoms, include most U.S. Food and Drug Administration approved plant derived anti-cancer agents. Evodiamine is an alkaloid with attractive multitargeting antiproliferative activity. Its high content in the natural source ensures its adequate supply on the market and guarantees further medicinal study. To the best of our knowledge, there is no systematic review about the antiproliferative effects of evodiamine derivatives. Therefore, in this article the review of the antiproliferative activities of evodiamine will be updated. More importantly, the antiproliferative activities of structurally modified new analogues of evodiamine will be summarized for the first time.

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24

Hao, Yanpeng, Zuchen Wei, Zhi Wang, Guiying Li, Yang Yao, and Baoqing Dun. "Biotransformation of Flavonoids Improves Antimicrobial and Anti-Breast Cancer Activities In Vitro." Foods 10, no. 10 (October 5, 2021): 2367. http://dx.doi.org/10.3390/foods10102367.

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Coarse cereals are rich in flavonoids, which are bioactive substances with a wide range of functions. Biotransformation is considered an emerging approach to methylate flavonoids, displaying prominent regio- and stereoselectivity. In the current study, liquiritigenin, naringenin, and hesperidin flavonoids were biotransformed using O-methyltransferases that were heterologously expressed in Saccharomyces cerevisiae BJ5464-NpgA. Nuclear magnetic resonance (NMR) spectroscopy was used together with high-resolution mass spectroscopy analysis to determine the structures of the resulting methylated transformants, and their antimicrobial and antiproliferation activities were also characterized. Among the five methylated flavonoids obtained, 7-methoxy-liquiritigenin had the strongest inhibitory effect on Candida albicans SC5314 (C. albicans SC5314), Staphylococcus aureus ATCC6538 (S. aureus ATCC6538), and Escherichia coli ATCC25922 (E. coli ATCC25922), which increased 7.65-, 1.49-, and 0.54-fold in comparison to the values of their unmethylated counterparts at 200, 250, and 400 μM, respectively. The results suggest that 3′-methoxyhesperetin showed the best antiproliferative activity against MCF-7 cells with IC50 values of 10.45 ± 0.45 µM, which was an increase of more than 14.35-fold compared to that of hesperetin. These results indicate that methylation enhances the antimicrobial activities and antiproliferative effects of flavonoids. The current study provides an experimental basis for further research on flavonoids as well as flavonoid-containing crops in the development of antimicrobial and anti-breast cancer drugs in addition to supplementary and health foods. The biotransformation method is ideal, as it represents a means for the sustainable production of bioactive flavonoids.

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25

El-Sayed, Amira A., Mahmoud F. Ismail, Abd El-Galil E. Amr, and Ahmed M. Naglah. "Synthesis, Antiproliferative, and Antioxidant Evaluation of 2-Pentylquinazolin-4(3H)-one(thione) Derivatives with DFT Study." Molecules 24, no. 20 (October 21, 2019): 3787. http://dx.doi.org/10.3390/molecules24203787.

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Анотація:

The current study was chiefly designed to examine the antiproliferative and antioxidant activities of some novel quinazolinone(thione) derivatives 6–14. The present work focused on two main points; firstly, comparing between quinazolinone and quinazolinthione derivatives. Whereas, antiproliferative (against two cell lines namely, HepG2 and MCF-7) and antioxidant (by two methods; ABTS and DPPH) activities of the investigated compounds, the best quinazolinthione derivatives were 6 and 14, which exhibited excellent potencies comparable to quinazolinone derivatives 5 and 9, respectively. Secondly, we compared the activity of four series of Schiff bases which included the quinazolinone moiety (11a–d). In addition, the antiproliferative and antioxidant activities of the compounds with various aryl aldehyde hydrazone derivatives (11a–d) analogs were studied. The compounds exhibited potency that increased with increasing electron donating group in p-position (OH > OMe > Cl) due to extended conjugated systems. Noteworthy, most of antiproliferative and antioxidant activities results for the tested compounds are consistent with the DFT calculations.

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26

Hong, Ji-Young, Su-Hyun Song, Hyen-Joo Park, Yong-Jin Cho, Jae-Ho Pyee, and Sang-Kook Lee. "Antioxidant, Antiinflamatory, and Antiproliferative Activities of Strawberry Extracts." Biomolecules and Therapeutics 16, no. 3 (September 30, 2008): 286–92. http://dx.doi.org/10.4062/biomolther.2008.16.3.286.

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27

Steinmeyer, Andreas, Gerald Kirsch, Gunter Neef, and Katica Schwarz. "New Synthetic Vitamin D Analogs with Antiproliferative Activities." Current Pharmaceutical Design 6, no. 7 (May 1, 2000): 767–89. http://dx.doi.org/10.2174/1381612003400470.

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28

Castillo, Quírico A., Jorge Triana, José L. Eiroa, José M. Padrón, Gabriela B. Plata, Ernesto V. Abel-Santos, Luis A. Báez, Diana C. Rodríguez, Marco A. Jiménez, and María F. Pérez-Pujols. "Flavonoids from Eupatorium illitum and Their Antiproliferative Activities." Pharmacognosy Journal 7, no. 3 (March 17, 2015): 178–81. http://dx.doi.org/10.5530/pj.2015.3.6.

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29

Zhang, Yaling, Shasha Ma, Xiabing Li, Qiaoli Hou, Mengjiao Lü, Yunxia Hao, Wei Wang, and Baolin Li. "Synthesis and Antiproliferative Activities of Novel Pyrrolotriazine Derivatives." Chinese Journal of Organic Chemistry 38, no. 12 (2018): 3270. http://dx.doi.org/10.6023/cjoc201805005.

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Rascón Valenzuela, Luisa Alondra, Manuel Jiménez Estrada, Carlos Arturo Velázquez Contreras, Adriana Garibay Escobar, Luis Angel Medina Juárez, Nohemi Gámez Meza, and Ramón Enrique Robles Zepeda. "Antiproliferative and apoptotic activities of extracts ofAsclepias subulata." Pharmaceutical Biology 53, no. 12 (May 5, 2015): 1741–51. http://dx.doi.org/10.3109/13880209.2015.1005752.

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Chang, Tsai-Yuan, Yun-Peng Tu, Win-Yin Wei, Hsiang Yu Chen, Chih-Shang Chen, Ying-Shuan E. Lee, Jiann-Jyh Huang, and Chin-Kang Sha. "Synthesis and Antiproliferative Activities of Ottelione A Analogues." ACS Medicinal Chemistry Letters 3, no. 12 (November 5, 2012): 1075–80. http://dx.doi.org/10.1021/ml300283f.

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32

Zhao, Ling, Jianping Chen, Jianyu Su, Lin Li, Songqing Hu, Bing Li, Xia Zhang, Zhenbo Xu, and Tianfeng Chen. "In VitroAntioxidant and Antiproliferative Activities of 5-Hydroxymethylfurfural." Journal of Agricultural and Food Chemistry 61, no. 44 (October 22, 2013): 10604–11. http://dx.doi.org/10.1021/jf403098y.

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33

Johnson, Jeffrey A., and J. David Gangemi. "Alpha Interferon Augments Cidofovir's Antiviral and Antiproliferative Activities." Antimicrobial Agents and Chemotherapy 47, no. 6 (June 2003): 2022–26. http://dx.doi.org/10.1128/aac.47.6.2022-2026.2003.

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ABSTRACT The antiviral and antiproliferative activities of alpha 2a interferon (IFN-α2a) and cidofovir in human papillomavirus type 16 (HPV-16)-transformed keratinocytes were evaluated. The compounds in combination were more effective than comparable levels of either drug alone. Evaluation of effective drug ratios revealed a synergistic cooperation between IFN-α2a and cidofovir in inhibiting the proliferation of HPV-infected cells.

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34

Li, Xue-Li, Yan-Hua Zhang, Cai-Fang Wang, and Qiu-An Wang. "Synthesis and antiproliferative activities of aminoalkylated polymethoxyflavonoid derivatives." Natural Product Research 33, no. 6 (December 11, 2017): 827–34. http://dx.doi.org/10.1080/14786419.2017.1413562.

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35

Liu, Yan-Ping, Qing Wen, Shi Hu, Yan-Lei Ma, Zhi-Hua Jiang, Jin-Ying Tang, Yan-Hui Fu, and Shen-Xiang Qiu. "Furanocoumarins with potential antiproliferative activities from Clausena lenis." Natural Product Research 33, no. 18 (April 18, 2018): 2631–37. http://dx.doi.org/10.1080/14786419.2018.1463530.

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36

Zhai, Xin, Ying He, Zhen Yang, and Ping Gong. "Syntheses and antiproliferative activities of novel diarylthiosemicarbazide derivatives." Chemical Research in Chinese Universities 29, no. 1 (January 16, 2013): 62–66. http://dx.doi.org/10.1007/s40242-013-2136-5.

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Leite-Legatti, Alice Vieira, Ângela Giovana Batista, Nathalia Romanelli Vicente Dragano, Anne Castro Marques, Luciana Gomes Malta, Maria Francesca Riccio, Marcos Nogueira Eberlin, et al. "Jaboticaba peel: Antioxidant compounds, antiproliferative and antimutagenic activities." Food Research International 49, no. 1 (November 2012): 596–603. http://dx.doi.org/10.1016/j.foodres.2012.07.044.

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Usia, Tepy, Arjun H. Banskota, Yasuhiro Tezuka, Kiyoshi Midorikawa, Katsumichi Matsushige, and Shigetoshi Kadota. "Constituents of Chinese Propolis and Their Antiproliferative Activities." Journal of Natural Products 65, no. 5 (May 2002): 673–76. http://dx.doi.org/10.1021/np010486c.

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39

Temburnikar, Kartik W., Sarah C. Zimmermann, Nathaniel T. Kim, Christina R. Ross, Christopher Gelbmann, Christine E. Salomon, Gerald M. Wilson, Jan Balzarini, and Katherine L. Seley-Radtke. "Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines." Bioorganic & Medicinal Chemistry 22, no. 7 (April 2014): 2113–22. http://dx.doi.org/10.1016/j.bmc.2014.02.033.

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40

Temburnikar, Kartik W., Christina R. Ross, Gerald M. Wilson, Jan Balzarini, Brian M. Cawrse, and Katherine L. Seley-Radtke. "Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines." Bioorganic & Medicinal Chemistry 23, no. 15 (August 2015): 4354–63. http://dx.doi.org/10.1016/j.bmc.2015.06.025.

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Ceylan, Şule, Yıldız Uygun Cebeci, Neslihan Demirbaş, Özge Özşen Batur, and Özlem Bingöl Özakpınar. "Antimicrobial, Antioxidant and Antiproliferative Activities of Novel Quinolones." ChemistrySelect 5, no. 36 (September 29, 2020): 11340–46. http://dx.doi.org/10.1002/slct.202002779.

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Machado, K. N., A. J. H. Tasco, M. J. Salvador, I. V. Rodrigues, C. Pessoa, I. J. O. Sousa, P. M. P. Ferreira, and A. M. do Nascimento. "Flavonoids, Antioxidant, and Antiproliferative Activities of Stevia urticifolia." Chemistry of Natural Compounds 53, no. 6 (November 2017): 1167–69. http://dx.doi.org/10.1007/s10600-017-2228-4.

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43

Kirmizibekmez, Hasan, Milena Masullo, Michela Festa, Anna Capasso, and Sonia Piacente. "Steroidal Glycosides with Antiproliferative Activities from Digitalis trojana." Phytotherapy Research 28, no. 4 (May 31, 2013): 534–38. http://dx.doi.org/10.1002/ptr.5012.

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Farhat, Zeinab, Tyler Scheving, Diana S. Aga, Pamela A. Hershberger, Jo L. Freudenheim, Rachael Hageman Blair, Manoj J. Mammen, and Lina Mu. "Antioxidant and Antiproliferative Activities of Several Garlic Forms." Nutrients 15, no. 19 (September 22, 2023): 4099. http://dx.doi.org/10.3390/nu15194099.

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It is hypothesized that garlic, Allium sativum, might protect against oxidative stress that causes damage to cells and tissues leading to the development of various health conditions including cancer. However, it is not known whether garlic’s potential anticancer benefits differ by form of garlic consumed. This study aimed to quantify and compare the in vitro antioxidant and antiproliferative activity of several garlic forms in water and alcohol extracts including fresh garlic, fresh garlic set aside, heated garlic, heated garlic set aside, garlic powder, black garlic, two commercially available garlic supplements. Antioxidant activity of different garlic forms were measured using three assays: DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) assay, superoxide assay, and hydroxyl assay. In vitro effects of garlic extracts were investigated against the most common lung cancer subtypes: H520, H1975, and A549 cell lines using the sulforhodamine B (SRB) assay. Among free radical scavenging assays, Garlicin®, a commercially available supplement, displayed high antioxidant activity in water and alcohol extracts (DPPH assay: 2.02 mg AAE (mg ascorbic acid equivalent)/g garlic and 3.53 mg AAE/g garlic, respectively; superoxide assay: 6.73 mg AAE/g garlic and 7.13 mg AAE/g garlic, respectively). In the hydroxyl assay, water extract of fresh garlic crushed and set aside for 10 min showed the highest antioxidant activity. Garlicin® alcohol extract and fresh garlic water extracts strongly inhibited the proliferation of H1975, A549 and H520 cells. Other forms of garlic including garlic powder and black garlic exhibited low antioxidant and antiproliferative activity. Our results demonstrate that the preparation and processing methods of garlic may lead to different antioxidant benefits.

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Salawu, K. M., A. A. Oyerinde, and R. H. Bello. "Antiproliferative and Antimicrobial Activities of Citrus limon (L.) Burm. f. Stem Bark Extract." Nigerian Journal of Basic and Applied Sciences 29, no. 1 (February 8, 2022): 49–54. http://dx.doi.org/10.4314/njbas.v29i1.6.

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Citrus limon is traditionally use for the treatment of several ailments including infectious diseases. This study was designed to evaluate antiproliferative and antimicrobial activities of Citrus limon stem bark extract. The plant material was collected, authenticated, air-dried and pulverized. Two hundred grams of powdered plant material was extracted into distilled methanol by cold maceration and the extract was concentration in a vacuo. The extract was subjected to in vitro phytochemical screening and bioassays including; antiproliferative assay (Sorghum bicolor radicle and Allium cepa root growth inhibitory assays) and antimicrobial susceptibility against Escherichia coli, Staphylococcus aureus, Citrobacter ferundii and Candida albicans. Phytochemical evaluation detected the presence of alkaloids, flavonoids and cardiac glycoside in the extract. The extract displayed concentration-dependent antiproliferative activity with an IC50 of 1.10±0.07 and 0.62±0.04 mg/mL compared to cyclophosphamide (IC50 of 0.17±0.02 and 0.83±0.08 mg/mL) for Sorghum bicolor radical growth and Allium cepa root growth inhibitory assays, respectively. The extract displayed antimicrobial activity with the highest activity against Escherichia coli and Citrobacter ferundii with activity indices of 0.68 and 0.59, respectively compared to gentamicin. Citrus limon stem bark extract displayed antiproliferative and antimicrobial activities.

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Volobuff, Carla R. F., Pedro C. O. Junior, Sidney M. dos Santos, Zefa V. Pereira, Diego C. Ferreira, Claudia A. L. Cardoso, Ana L. T. G. Ruiz, Mary A. Foglio, João E. de Carvalho, and Anelise S. N. Formagio. "Antitumoral and Anticholinesterasic Activities of the Seven Species from Rubiaceae." Current Pharmaceutical Biotechnology 20, no. 4 (May 28, 2019): 302–8. http://dx.doi.org/10.2174/1389201020666190211154550.

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Background: The genus Psychotria and Palicourea are reported as a source of alkaloids and iridoids, which exhibit biological activities. This study aimed to evaluate antiproliferative and anticholinesterase activities and quantification of the alkaloids of seven species among the genus found in Mato Grosso do Sul region in Brazil. Methods: Concentrations of alkaloids were measured spectrophotometrically. The extracts were submitted to antiproliferative activity against ten cell lines. The anticholinesterase activity of the extracts was developed using brain structures of male Wistar rats: cerebral cortex, hippocampus, hypothalamus and striatum by the Ellman method. Results: Alkaloids from Psychotria and Palicourea species were quantified which showed values of 47.6 to 21.9 µg/g. Regarding the antiproliferative potential, Palicourea crocea demonstrated selectivity against the 786-0 cell line (GI50: 22.87 µg/mL). Psychotria leiocarpa inhibited cell growth against OVCAR-3 (GI50: 3.28 µg/mL), K-562 (GI50: 5.26 µg/mL), HaCaT (GI50: 27.20 µg/mL), PC-3 (GI50: 34.92 µg/mL), MCF-7 (GI50: 35.80 µg/mL) and P. capillacea showed activity against OVCAR-3 (GI50: 2.33 µg/ml) and U251 (GI50: 16.66 µg/ml). The effect of acetylcholinesterase inhibition was more effective in the hippocampus, demonstrating inhibition for Paliourea crocea, Psychotria deflexa, P. brachybotrya and P. leiocarpa of 70%, 57%, 50% and 40%, respectively, followed by P. poeppigiana and P. capillacea, inhibiting 21%, compared to the control. Conclusion: Herein, the present work showed for the first time, anticholinesterasic and antiproliferative activities of extracts of Palicourea and Psychotria seem to be mainly associated with the levels of alkaloids in the leaves of these species.

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Manosroi, Aranya, Hiroyuki Akazawa, Worapong Kitdamrongtham, Toshihiro Akihisa, Worapaka Manosroi, and Jiradej Manosroi. "Potent Antiproliferative Effect on Liver Cancer of Medicinal Plants Selected from the Thai/Lanna Medicinal Plant Recipe Database “MANOSROI III”." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/397181.

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Thai/Lanna medicinal plant recipes have been used for the treatment of several diseases including liver cancer. In this study, methanolic extracts (MEs) of 23 plants were tested for antiproliferative activity on human hepatoma cell line (Hep G2) by the sulforhodamine B (SRB) assay. Nine MEs with potent antiproliferative activity (IC50< 100 µg/mL) were obtained and further semipurified by liquid/liquid partition extraction. The semipurified fractions were tested for the antiproliferative and antioxidative activities. ME ofStemona collinsaeand the semipurified extract and methanol-water fraction (MF) ofGloriosa superbagave the highest antiproliferative activity on HepG2 which were 4.79- and 50.07-fold cisplatin, respectively. The semipurified fractions showed an increased antiproliferative activity. MF ofCaesalpinia sappanand HF ofSenna alatashowed the highest free radical scavenging and metal chelating activities, respectively. The compound inn-hexane fraction (HF) ofVentilago denticulatawhich showed an increase in antiproliferative activity comparing to its ME was isolated and identified as emodin. This study has demonstrated the potential of the ME fromS. collinsae, MF fromG. superba, and emodin isolated fromV. denticulata, for further development as an antiliver cancer agent.

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Lai, Zhen-Rung, Yu-Ling Ho, Shun-Chieh Huang, Tai-Hung Huang, Shang-Chih Lai, Jen-Chieh Tsai, Ching-Ying Wang, Guan-Jhong Huang, and Yuan-Shiun Chang. "Antioxidant, Anti-inflammatory and Antiproliferative Activities of Kalanchoe gracilis (L.) DC Stem." American Journal of Chinese Medicine 39, no. 06 (January 2011): 1275–90. http://dx.doi.org/10.1142/s0192415x1100955x.

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Oxidative stress and inflammation are related to several chronic diseases including cancer and atherosclerosis. Kalanchoe gracilis (L.) DC is a special folk medicinal plant in Taiwan. The aim of this study was to evaluate the antioxidant, anti-inflammatory and antiproliferative activities of the methanolic extract and fractions of the stem of K. gracilis. TEAC, total phenolic compound content, total flavonoid content, DPPH radical scavenging activity, reducing power, inhibition of NO production in LPS-induced RAW264.7 cells, and inhibition of cancer cell proliferation were analyzed. Among all fractions, the chloroform fraction showed the highest TEAC and DPPH radical scavenging activities. The chloroform fraction also had the highest content of polyphenols and flavonoids. Chloroform fractions also decreased LPS-induced NO production and expressions of iNOS and COX-2 in RAW264.7 cells. The antiproliferative activities of the methanolic extract and fractions were studied in vitro using HepG2 cells, and the results were consistent with their antioxidant capacities. Chloroform fractions had the highest antiproliferative activity with an IC50 of 136.85 ± 2.32 μg/ml. Eupafolin also had good pharmacological activity in the antioxidant, anti-inflammation and antiproliferative. Eupafolin might be an important bioactive compound in the stem of K. gracilis. The above experimental data indicated that the stem of K. gracilis is a potent antioxidant medicinal plant, and such efficacy may be mainly attributed to its polyphenolic compounds.

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Tsitsa, Ifigenia, Alketa Tarushi, Panagiota Doukoume, Franc Perdih, Andreia de Almeida, Athanasios Papadopoulos, Stavros Kalogiannis, Angela Casini, Iztok Turel, and George Psomas. "Structure and biological activities of metal complexes of flumequine." RSC Advances 6, no. 23 (2016): 19555–70. http://dx.doi.org/10.1039/c5ra25776j.

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Janicsák, Gábor, István Zupkó, Milena T. Nikolova, Peter Forgo, Andrea Vasas, Imre Máthé, Gerald Blunden, and Judit Hohmann. "Bioactivity-guided Study of Antiproliferative Activities of Salvia Extracts." Natural Product Communications 6, no. 5 (May 2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600501.

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The cytotoxic activities of the n-hexane, chloroform and aqueous methanolic fractions prepared from the methanolic extract of the leaves of 23 Salvia taxa were studied for their cell growth-inhibitory activity against human cervix adenocarcinoma (HeLa), skin carcinoma (A431) and breast adenocarcinoma (MCF7) cells using the MTT assay. The n-hexane fractions of six Salvia taxa (S. hispanica, S. nemorosa, S. nemorosa l. albiflora, S. pratensis, S. recognita and S. ringens) and the chloroform fraction of S. officinalis l. albiflora produced over 50% growth inhibition of the skin carcinoma cell line. None of the tested extracts showed substantial (above 50%) antiproliferative effects against HeLa and MCF7 cells. S. ringens was the most powerful among the studied Salvia species with a 61.8% cell growth inhibitory activity on A431 cells. In the case of S. ringens, other plant parts were also tested for antiproliferative effect, and the highest activities were recorded for the root extract. This was subjected to bioactivity-guided fractionation, which yielded four abietane diterpenes (royleanone, horminone, 7- O-methyl-horminone and 7-acetyl-horminone), one triterpene (erythrodiol-3-acetate) and β-sitosterol. Horminone, 7-acetyl-horminone and erythrodiol-3-acetate displayed marked concentration-dependent antiproliferative effects, while royleanone and 7 -O-methyl-horminone produced weaker activities.

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