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1
Ademovic, Zahida, Snjezana Hodzic, Zarka Halilic-Zahirovic, Darja Husejnagic, Jasna Dzananovic, Broza Saric-Kundalic, and Jasmin Suljagic. "Phenolic compounds, antioxidant and antimicrobial properties of the wild cherry (Prunus avium L.) stem." Acta Periodica Technologica, no. 48 (2017): 1–13. http://dx.doi.org/10.2298/apt1748001a.
Анотація:
The aim of this study was to determine the total phenolic content, evaluate antioxidant propertie and antimicrobial potential, and identify phenolic compounds in alcoholic and aqueous extracts of the wild cherry (Prunus avium L.) stems collected in Bosnia and Herzegovina. Alcoholic extracts had higher contents of phenolic and flavonoid components, as well as the antioxidant and ferric reducing antioxidant capacity in comparison to aqueous extracts. All extracts were characterized by HPLC analysis. Furthermore, for the first time, the antimicrobial properties of wild cherry stem extracts were evaluated. Quercetin and (+)-catechin were the main compounds identified in the alcoholic extract, followed by chlorogenic acid and rutin. Quercetin was also the major component detected in aqueous extracts. Besides, alcoholic extract showed better antibacterial properties against Staphylococcus aureus as a representative gram-positive bacteria than infusion, whereas none of the samples showed antibacterial activity against Escherichia coli and fungus Candida albicans.
2
Benhelima, Abdelkader, Olivier Vidal, Zohra Kaid-Omar, Rabea Sahki, and Jean-Marie Lacroix. "Antibacterial, Antibiofilm and Antioxidant Activities of some Medicinal Plants from Pharmacopoeia of Tassili N’ajjer." Journal of Pure and Applied Microbiology 14, no. 3 (August 24, 2020): 1835–44. http://dx.doi.org/10.22207/jpam.14.3.22.
Анотація:
Three plants adopted by nomads at Tassili n’ajjer (south Algeria) in traditional medicine namely, Cymbopogon schoenanthus, Anabasis articulata and Salvia chudaei, were analysed for theirs antibacterial, antibiofilm and antioxidant properties. Total flavonoid and phenolic contents were measured with 2% AlCl3 and Folin-Ciocalteu’s reagent method, respectively. The antibacterial propertie was investigated by measurement of MIC of plants extract inhibing bacterial proliferation. The antibiofilm propertie was calculated by fluorescent quantization of the DAPI labeled bacterial biomass fixed on the surface and by COMSTAT analysis of confocal scanning laser microscopy (CSLM) images. DPPH radical scavenging and β-carotene/linoleate bleaching methods were used to determine the antioxidant activities of the plants. Total phenolic content was ranged from 21.98 to 2.51 (gallic acid equivalents mg/g methanolic extracts) and the total flavonoid content ranged from 19.27 to 1.65 (catechin equivalent mg/g methanolic extracts). Antibacterial activity against four Gram positive bacteria was shown with plants extracts. The biofilm inhibition concentration of extracts decreasing 50% of biofilm cell density (BIC50) for Salvia chudaei and Cymbopogon schoenanthus extracts ranges from 1 to 10 µg/mL. CSLM images analysis revealed that both surface covering by germ and three dimensional development of the biofilm were reduced with plants extracts. For antioxidant activities, the methanol extracts of the plants evaluated showed low antioxidant activity, with a IC50 between 1.94 and 6.16 mg/ml. Thus, Our systematic research showed that this three common plants of Sahara desert has diversified phytochemicals possessing satisfying extent of antimicrobial, antibiofilm and antioxidant activities.
3
Leitão, Jorge, Silvia Sousa, Silvestre Leite, and Maria Carvalho. "Silver Camphor Imine Complexes: Novel Antibacterial Compounds from Old Medicines." Antibiotics 7, no. 3 (July 26, 2018): 65. http://dx.doi.org/10.3390/antibiotics7030065.
Анотація:
The emergence of bacterial resistance to available antimicrobials has prompted the search for novel antibacterial compounds to overcome this public health problem. Metal-based complexes have been much less explored than organic compounds as antimicrobials, leading to investigations of the antimicrobial properties of selected complexes in which silver may occupy the frontline due to its use as medicine since ancient times. Like silver, camphor has also long been used for medicinal purposes. However, in both cases, limited information exists concerning the mechanisms of their antimicrobial action. This work reviews the present knowledge of the antimicrobial properties of camphor-derived silver complexes, focusing on recent research on the synthesis and antimicrobial properties of complexes based on silver and camphor imines. Selected examples of the structure and antimicrobial activity relationships of ligands studied so far are presented, showing the potential of silver camphorimine complexes as novel antimicrobials.
4
Otero, María Carolina, Juan A. Fuentes, Cristian Atala, Sara Cuadros-Orellana, Camila Fuentes, and Felipe Gordillo-Fuenzalida. "Antimicrobial Properties of Chilean Native Plants: Future Aspects in Their Application in the Food Industry." Foods 11, no. 12 (June 15, 2022): 1763. http://dx.doi.org/10.3390/foods11121763.
Анотація:
Food contamination with microorganisms is responsible for food spoilage, deterioration and change of organoleptic properties of foods. Besides, the growth of pathogenic microorganisms can provoke serious health problems if food is consumed. Innovative packaging, such as active packaging, is increasing rapidly in the food industry, especially in applying antimicrobials into delivery systems, such as sachets. Chile is a relevant hotspot for biodiversity conservation and a source of unique bio-resources with antimicrobial potential. In this review, fifteen native plants with antimicrobial properties are described. Their antimicrobial effects include an effect against human pathogens. Considering the emergence of antimicrobial resistance, searching for new antimicrobials to design new strategies for food pathogen control is necessary. Chilean flora is a promising source of antimicrobials to be used in active packaging. However, further studies are required to advance from laboratory tests of their antimicrobial effects to their possible effects and uses in active films.
5
TUTAR, Uğur, and Cem ÇELİK. "Antibiofilm and Antimicrobial Properties of 1-allyl-3-(2-diisopropylaminoethyl) Benzimidazolium Chloride and its Silver(I)-NHC Complex." Cumhuriyet Science Journal 43, no. 3 (September 30, 2022): 432–36. http://dx.doi.org/10.17776/csj.1121787.
Анотація:
Today, the number of antimicrobials used in treatment has decreased, especially due to drug resistance. We need new antimicrobials. Biofilms are an important cause of antimicrobial resistance. In this study, the antimicrobial and antibiofilm properties of the salt and silver complex of benzimidazolium-based NHC compound, which were previously synthesized and characterized, were evaluated. The antimicrobial properties were tested using the broth microdilution method, while their antibiofilm potential was determined by microtiter plate assay. Salt of the NHC compound (1a) showed antimicrobial activity on microorganisms at concentrations between 31.25-125 µg/mL. The silver complex (2a) of the NHC compound showed higher antimicrobial and antibiofilm activity than the salt compound. This activity was highest on Candida albicans yeast (MIC 3.9 µg/mL). Compound 2a reduced the biofilm structure of C. albicans yeast by 86.1% compared to the control. In addition, compound 2a showed 76.4-80.6% antibiofilm activity on gram-negative bacteria. NHC compounds are seen as a promising resource for the development of new generation antimicrobials. The NHC compound evaluated in this study was found to have significant antimicrobial and antibiofilm activity. These compounds could be an important resource for the discovery of future biofilm-acting antimicrobials.
6
Šmidrkal, J., T. Karlová, V. Filip, M. Zárubová, and I. Hrádková. "Antimicrobial properties of 11-cyclohexylundecanoic acid." Czech Journal of Food Sciences 27, No. 6 (December 23, 2009): 463–69. http://dx.doi.org/10.17221/181/2009-cjfs.
Анотація:
The fact that milk fat contains many minor fatty acids is mostly neglected. It is known that 11-cyclohexylundecanoic acid is contained in cow’s milk fat in the amount of 0.1–0.2%. It is also contained in human milk. 11-Cyclohexylundecanoic acid was synthesised, purified to 99.5% (GC) and its antimicrobial properties were investigated. It was found that 11-cyclohexylundecanoic acid has inhibitory effects on <i>Bacillus cereus</i>, <i>Escherichia coli</i>, and <i>Fusarium culmorum</i> from the concentration of 0.05 mmol/l, however, no antimicrobial effect on Saccharomyces cerevisiae has been determined. 11-Cyclohexylundecanoic acid was found also in goat and cow milk fat on the level of 0.1–0.2%. It is convenient to hydrogenate the sample of fat before the determination of 11-cyclohexylundecanoic acid by GC method. Keywords:
7
Pereira da Silva Junior, João Portilho, Janaina Da Costa Nogueira, Waldireny Rocha Gomes, and Adriana Dantas Gonzaga de Freitas. "Avaliação In Vitro do Potencial Antimicrobiano de Extratos do Urucum (Bixa orellana L.)." UNICIÊNCIAS 27, no. 2 (December 13, 2023): 130–33. http://dx.doi.org/10.17921/1415-5141.2023v27n2p130-133.
Анотація:
A espécie Bixa orellana L., popularmente conhecida como urucum, é utilizada como corante. Embora estudos descrevam propriedades medicinais da Bixa orellana L., ainda há poucos relatos sobre suas propriedades anti-inflamatórias e antimicrobianas, abrindo assim maiores possibilidades de estudos envolvendo essa planta. A investigação da atividade antimicrobiana, em espécies vegetais, se apresenta como uma alternativa a um problema emergente de saúde pública, a resistência microbiana, que vem aumentando, de forma alarmante, por conta do uso indiscriminado de antibióticos pela população. Esta pesquisa teve como objetivo avaliar o potencial antimicrobiano dos extratos de folhas, cascas e sementes do urucum, a partir de processos de extração de compostos ativos por ultrassom e soxhlet. Os extratos obtidos foram analisados frente a quatro micro-organismos patogênicos Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa e Klebsiella pneumoniae. A avaliação da atividade antimicrobiana ocorreu através do método de difusão em disco em meio Miller Hinton, os discos contendo os extratos vegetais foram depositados sobre as culturas bacterianas previamente inoculadas, o teste foi realizado em triplicata. O principal resultado observado foi o halo de inibição com extratos de folhas para Pseudomonas aeruginosa e Klebsiella pneumoniae, enquanto para os testes com extratos da casca apresentou halo inibitório contra Staphylococcus aureus. Novos testes devem ser realizados para comprovar a atividade antimicrobiana desta espécie. Palavras-chave: Bixa orellana L. Urucum. Potencial Antimicrobiano. Extratos. Abstract The species Bixa orellana L. popularly known as annatto, is used as a natural coloring and food coloring. Although studies describe medicinal properties of Bixa orellana, there are still few reports on its anti-inflammatory and antimicrobial properties, thus opening up greater possibilities for studies involving this plant. The investigation of antimicrobial activity in plant species with medicinal potential is an alternative to an emerging public health problem, microbial resistance, which has been increasing alarmingly due to the indiscriminate use of antibiotics by the population. Research in the area of microbiology is necessary in the search for new active compounds, especially those from natural sources that can act to combat these new strains. This research aimed to evaluate the antimicrobial potential of extracts of annatto leaves, bark and seeds based on active compound extraction processes using ultrasound and soxhlet. The extracts obtained were analyzed against four pathogenic microorganisms Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. The evaluation of antimicrobial activity was carried out using the disk diffusion method in Miller Hinton medium, the disks containing the plant extracts were deposited on the previously inoculated bacterial cultures, the test was carried out in triplicate. The main results observed were the inhibition halo with leaf extracts for Pseudomonas aeruginosa and Klebsiella pneumoniae, while tests with bark extracts showed an inhibitory halo against Staphylococcus aureus. New tests must be developed to prove the antimicrobial activity of this species. Keywords: Bixa orellana L. Annatto. Antimicrobial Potential. Extracts.
8
MacDermott-Opeskin, Hugo I., Vrinda Gupta, and Megan L. O’Mara. "Lipid-mediated antimicrobial resistance: a phantom menace or a new hope?" Biophysical Reviews 14, no. 1 (February 2022): 145–62. http://dx.doi.org/10.1007/s12551-021-00912-8.
Анотація:
Abstract The proposition of a post-antimicrobial era is all the more realistic with the continued rise of antimicrobial resistance. The development of new antimicrobials is failing to counter the ever-increasing rates of bacterial antimicrobial resistance. This necessitates novel antimicrobials and drug targets. The bacterial cell membrane is an essential and highly conserved cellular component in bacteria and acts as the primary barrier for entry of antimicrobials into the cell. Although previously under-exploited as an antimicrobial target, the bacterial cell membrane is attractive for the development of novel antimicrobials due to its importance in pathogen viability. Bacterial cell membranes are diverse assemblies of macromolecules built around a central lipid bilayer core. This lipid bilayer governs the overall membrane biophysical properties and function of its membrane-embedded proteins. This mini-review will outline the mechanisms by which the bacterial membrane causes and controls resistance, with a focus on alterations in the membrane lipid composition, chemical modification of constituent lipids, and the efflux of antimicrobials by membrane-embedded efflux systems. Thorough insight into the interplay between membrane-active antimicrobials and lipid-mediated resistance is needed to enable the rational development of new antimicrobials. In particular, the union of computational approaches and experimental techniques for the development of innovative and efficacious membrane-active antimicrobials is explored.
9
Permatananda, Pande Ayu Naya Kasih, I Gde Suranaya Pandit, Putu Nita Cahyawati, and Anak Agung Sri Agung Aryastuti. "Antimicrobial Properties of Eco Enzyme: A Literature Review." Bioscientia Medicina : Journal of Biomedicine and Translational Research 7, no. 6 (July 21, 2023): 3370–76. http://dx.doi.org/10.37275/bsm.v7i6.831.
Анотація:
Background: In surgical medicine, the use of antimicrobials is very important. The use of antimicrobials or antibiotics is used at the time before surgery as prophylaxis, intraoperative, and postoperative. The prevention of some bacterial infections is imperative. The latest research is constantly evolving toward the use of antibiotics, which follows an increasingly resistant antibiotic trend. One of the advancements in the use of antimicrobials is eco enzymes.
Methods: The literatures reviewed in our study was gathered from PubMed and Google Scholar. The advanced search was conducted on PubMed with the keywords used ("Eco enzyme" AND "antimicrobial" AND "activity" OR "Antibiotics"; "Mechanism" OR "Nature"). The advanced search was also conducted on Google Scholar with all of the words "antimicrobial activity of eco enzyme". We reviewed the articles cited within the literature to broaden the search results.
Results: Some materials used as eco enzymes in this literature review include Carica papaya L., Annona muricata L., Azadirachta indica Cymbopogon winterianus, Ananas comosus, citrus aurantium, etc. Bioactive substances that play a role in microbacterial activity are flavonoids, tannins, saponins, pH, and lactic acids through mechanisms inhibiting nucleic acid synthesis, inhibit cell membrane function, inhibiting energy metabolism of bacteria, and cross-bacterial cell membranes because of the pH gradient, leading to the disruption of cellular metabolic activities of bacterias.
Conclusion: Eco enzymes have been shown to have antimicrobial abilities.
10
Svizhak, V. K., S. E. Dejneka, V. A. Chornous, O. I. Azarov, and V. J. Svizhak. "Antimicrobial Properties of New Derivatives of Imidazole." Mikrobiolohichnyi Zhurnal 79, no. 5 (September 30, 2017): 46–56. http://dx.doi.org/10.15407/microbiolj79.05.046.
11
Bartošová, E., R. Červenková, Z. Špičková, J. Šmidrkal, V. Filip, and M. Plocková. "Monoacylglycerols as food additives with antimicrobial properties." Czech Journal of Food Sciences 22, SI - Chem. Reactions in Foods V (January 1, 2004): S238—S241. http://dx.doi.org/10.17221/10670-cjfs.
Анотація:
The antimicrobial activities of monoacylglycerols (MAGs) with different lengths of hydrophobic hydrocarbon chains (1-decanoylglycerol, 1-undecanoylglycerol, 1-dodecanoylglycerol, 1-tridecanoylglycerol, 1-tetradecanoylglycerol) were investigated. Food undesirable bacterial strain Bacillus subtilis DMF 2006 and mould strains Aspergillus niger DMF 0501 and Fusarium culmorum DMF 0103 were used as indicator strains in order to determine antimicrobial properties of monoacylglycerols. The strongest antibacterial effect was caused by 1-undecanoylglycerol, 1-dodecanoylglycerol, 1-tridecanoylglycerol. These substances inhibited growth of Bacillus subtilis DMF 2006 for more then 10 days of incubation at the concentration of 0.05 mg/ml. Concentrations of 0.05 and 0.07 mg/ml of 1-decanoylglycerol, 1-undecanoylglycerol, 1-dodecanoylglycerol reduced the mycelium formation of Fusarium culmorum and Aspergillus niger. Higher concentrations (0.1 and 0.5 mg/ml) of these three substances inhibited spore germination. Knowledge of these properties brings new approach in food preservation where the substitute of chemical substances, such as sorbic and benzoic acids and their salts is in demand.
12
Feldeková, Eva, Michaela Kosová, Markéta Berčíková, Miroslav Dragoun, Iveta Klojdová, Iveta Hrádková, and Jan Šmidrkal. "Antimicrobial properties of phenolic acid alkyl esters." Czech Journal of Food Sciences 40, No. 6 (December 21, 2022): 438–44. http://dx.doi.org/10.17221/135/2022-cjfs.
Анотація:
The series of phenolic acid (2-, 3-, 4-monohydroxy- and 2,4-, 2,5-dihydroxy) alkyl esters (methyl, ethyl, propyl, and butyl) were prepared, and their antimicrobial activities were determined. The antimicrobial activity against the tested microorganisms Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans and Aspergillus brasiliensis was investigated and expressed by minimum inhibitory concentration (MIC) in the range of 1.2–20 mM. The inhibitory activity of higher esters of phenolic acids was found to be higher than that of methyl esters and acids. The minimum inhibitory concentration (MIC) of tested compounds was compared with that of 4-hydroxybenzoic acid and its esters (parabens).
13
Paraska, Olga, Hrystyna Kovtun, Lubos Hes, and Serhiy Horiashchenko. "STUDY OF THE INFLUENCE OF ANTIMICROBIAL AGENTS ON THE OPERATIONAL AND HYGIENIC PROPERTIES OF CELLULOSE MATERIALS." Fibres and Textiles 29, no. 2 (August 2022): 74–79. http://dx.doi.org/10.15240/tul/008/2022-2-008.
Анотація:
At the present stage of development of society, in pandemic conditions, people are experiencing the growing influence of man-made factors (energy flows of internal and external origin, ionizing radiation, etc.), some drugs, pathogenic microflora (fungi, viruses, bacteria, intracellular parasites). The origination of a critical mass of parasitogens can be prevented by using, in addition to traditional methods of prevention and treatment, textile materials with certain additional properties obtained by antimicrobial treatment. The aim is to study the change in the operational and hygienic properties of cellulosic materials after treatment with antimicrobials. To assess the effect of antimicrobials (biguanide derivatives and quaternary ammonium salts) on the operational and hygienic properties of cellulosic materials (cotton fabric) the following indicators were taken into account: strength, stiffness, wrinkle recovery, capillarity of materials, structural and morphological characteristics. The results of research have confirmed the possibility of using solutions of antimicrobial agents for effective processing of wares, without destructive effects on the structure of cellulosic materials; allowed to introduce a research methodology to provide antimicrobial properties of cellulosic materials of different assortment.
14
Olatunde, Oladipupo Odunayo, Soottawat Benjakul, and Ahmet Faruk Yesilsu. "Antimicrobial Compounds from Crustaceans and Their Applications for Extending Shelf-Life of Marine-Based Foods." Turkish Journal of Fisheries and Aquatic Sciences 20, no. 8 (2020): 629–46. http://dx.doi.org/10.4194/1303-2712-v20_8_06.
Анотація:
Antimicrobial-resistant microorganisms have become a major challenge for public health and food industries because of their fast adaptability and slow response to synthetic antimicrobials. Bioactive compounds from marine sources exert various biological roles including antioxidant, antimicrobial, anti-inflammatory, antihypertensive, and anticancer properties. Their advantage as an antimicrobial compound is gradually be exploited, particularly in marine-based foods (MBFs), which are highly perishable since they are abundant in proteins, lipids, and other nutrients. Also, the growing demand for fresh products with prolonged shelf-life is making the MBFs industry to urgently seek the effective methods for preservation of fresh or refrigerated MBFs. Crustaceans, which are invertebrates, are valuable source of essential nutrient based on their richness in protein, carbohydrate, minerals, lipids, and vitamins. Additionally, the by-product from the processing of crustaceans could be used as an alternative source of antimicrobials, which can be employed in MBFs as natural preservatives. This review therefore revisited the recovery of antimicrobials compounds such as antimicrobial peptides, carotenoids, and chitosan derivatives from crustaceans. The uses of these crustacean antimicrobials in extending the shelf-life of MBFs are also discussed.
15
Kamaruzzaman, Nor Fadhilah, Li Peng Tan, Ruhil Hayati Hamdan, Siew Shean Choong, Weng Kin Wong, Amanda Jane Gibson, Alexandru Chivu, and Maria de Fatima Pina. "Antimicrobial Polymers: The Potential Replacement of Existing Antibiotics?" International Journal of Molecular Sciences 20, no. 11 (June 4, 2019): 2747. http://dx.doi.org/10.3390/ijms20112747.
Анотація:
Antimicrobial resistance is now considered a major global challenge; compromising medical advancements and our ability to treat infectious disease. Increased antimicrobial resistance has resulted in increased morbidity and mortality due to infectious diseases worldwide. The lack of discovery of novel compounds from natural products or new classes of antimicrobials, encouraged us to recycle discontinued antimicrobials that were previously removed from routine use due to their toxicity, e.g., colistin. Since the discovery of new classes of compounds is extremely expensive and has very little success, one strategy to overcome this issue could be the application of synthetic compounds that possess antimicrobial activities. Polymers with innate antimicrobial properties or that have the ability to be conjugated with other antimicrobial compounds create the possibility for replacement of antimicrobials either for the direct application as medicine or implanted on medical devices to control infection. Here, we provide the latest update on research related to antimicrobial polymers in the context of ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) pathogens. We summarise polymer subgroups: compounds containing natural peptides, halogens, phosphor and sulfo derivatives and phenol and benzoic derivatives, organometalic polymers, metal nanoparticles incorporated into polymeric carriers, dendrimers and polymer-based guanidine. We intend to enhance understanding in the field and promote further work on the development of polymer based antimicrobial compounds.
16
Nevin Cankaya, Nevin Cankaya. "Grafting of Chitosan: Structural, Thermal and Antimicrobial Properties." Journal of the chemical society of pakistan 41, no. 2 (2019): 240. http://dx.doi.org/10.52568/000735/jcsp/41.02.2019.
Анотація:
In this study, some new chitosan materials were synthesized by the grafting of chitosan with the monomers such as 1-vinylimidazole (VIM), methacrylamide (MAm) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS). First of all, chitosan methacrylate was prepared by esterification of primary -OH group with methacryloyl chloride a 25.13% yield by mole. The monomers were grafted into chitosan methacrylate via free radical polymerization using 2,2and#39;-Azobisisobutyronitrile as an initiator in N,N-dimethylformamide. The graft copolymers were characterized by FT-IR spectra and elemental analysis. Thermal stabilities of the graft copolymers were determined by TGA (thermo gravimetric analysis) method. The synthesized chitosan methacrylate and its graft copolymers were tested for their antimicrobial activity against bacteria and yeast.
17
Ben-Fadhel, Yosra, Behnoush Maherani, Melinda Aragones, and Monique Lacroix. "Antimicrobial Properties of Encapsulated Antimicrobial Natural Plant Products for Ready-to-Eat Carrots." Foods 8, no. 11 (November 1, 2019): 535. http://dx.doi.org/10.3390/foods8110535.
Анотація:
The antimicrobial activity of natural antimicrobials (fruit extracts, essential oils and derivates), was assessed against six bacteria species (E. coli O157:H7, L. monocytogenes, S. Typhimurium, B. subtilis, E. faecium and S. aureus), two molds (A. flavus and P. chrysogenum) and a yeast (C. albicans) using disk diffusion method. Then, the antimicrobial compounds having high inhibitory capacity were evaluated for the determination of their minimum inhibitory, bactericidal and fungicidal concentration (MIC, MBC and MFC respectively). Total phenols and flavonoids content, radical scavenging activity and ferric reducing antioxidant power of selected compounds were also evaluated. Based on in vitro assays, five antimicrobial compounds were selected for their lowest effective concentration. Results showed that, most of these antimicrobial compounds had a high concentration of total phenols and flavonoids and a good anti-oxidant and anti-radical activity. In situ study showed that natural antimicrobials mix, applied on the carrot surface, reduced significantly the count of the initial mesophilic total flora (TMF), molds and yeasts and allowed an extension of the shelf-life of carrots by two days as compared to the control. However, the chemical treatment (mix of peroxyacetic acid and hydrogen peroxide) showed antifungal activity and a slight reduction of TMF.
18
Rao, Jiajia, Bingcan Chen, and David Julian McClements. "Improving the Efficacy of Essential Oils as Antimicrobials in Foods: Mechanisms of Action." Annual Review of Food Science and Technology 10, no. 1 (March 25, 2019): 365–87. http://dx.doi.org/10.1146/annurev-food-032818-121727.
Анотація:
The consumer preference for clean-label products is requiring the food industry to reformulate their products by replacing artificial additives with natural alternatives. Essential oils are natural antimicrobials isolated from plant sources that have the potential to combat many foodborne pathogens and spoilage organisms. This review begins by discussing the antimicrobial properties of essential oils, the relationships between their chemical structure and antimicrobial efficacy, and their potential limitations for commercial applications (such as strong flavor, volatility, and chemical instability). We then review the commonly used methods for screening the antimicrobial efficacy of essential oils and elucidating their mechanisms of action. Finally, potential applications of essential oils as antimicrobials in foods are reviewed and the major types of food-grade delivery systems available for improving their efficacy are discussed.
19
Yang, Yuheng, and Tong Zhang. "Antimicrobial Activities of Tea Polyphenol on Phytopathogens: A Review." Molecules 24, no. 4 (February 25, 2019): 816. http://dx.doi.org/10.3390/molecules24040816.
Анотація:
The use of natural antimicrobial compounds in crop production has gained much attention from consumers and the agricultural industry. Consequently, interest in more natural, non-synthetic antimicrobials as potential alternatives to conventional chemical pesticides to combat phytopathogens has heightened. Tea polyphenol (TP), a unique and highly important functional component of tea plants, has been reported to possess antimicrobial properties against a wide spectrum of plant pathogens. The aim of this review is to discuss the emerging findings on the mechanisms of antimicrobial action, and the antimicrobial properties of TP, including their major components, effectiveness, and synergistic effects. More studies, particularly field studies, are still necessary to establish conclusive evidence for the effectiveness of TP against phytopathogens. However, the basic conclusion from existing studies suggests that TP is a potential antimicrobial agent for pesticide reduction in agricultural systems.
20
Becerril, Raquel, Cristina Nerín, and Filomena Silva. "Encapsulation Systems for Antimicrobial Food Packaging Components: An Update." Molecules 25, no. 5 (March 3, 2020): 1134. http://dx.doi.org/10.3390/molecules25051134.
Анотація:
Antimicrobial active packaging has emerged as an effective technology to reduce microbial growth in food products increasing both their shelf-life and microbial safety for the consumer while maintaining their quality and sensorial properties. In the last years, a great effort has been made to develop more efficient, long-lasting and eco-friendly antimicrobial materials by improving the performance of the incorporated antimicrobial substances. With this purpose, more effective antimicrobial compounds of natural origin such as bacteriocins, bacteriophages and essential oils have been preferred over synthetic ones and new encapsulation strategies such as emulsions, core-shell nanofibres, cyclodextrins and liposomes among others, have been applied in order to protect these antimicrobials from degradation or volatilization while trying to enable a more controlled release and sustained antimicrobial action. On that account, this article provides an overview of the types of antimicrobials agents used and the most recent trends on the strategies used to encapsulate the antimicrobial agents for their stable inclusion in the packaging materials. Moreover, a thorough discussion regarding the benefits of each encapsulation technology as well as their application in food products is presented.
21
Pinto, Loris, Melvin R. Tapia-Rodríguez, Federico Baruzzi, and Jesús Fernando Ayala-Zavala. "Plant Antimicrobials for Food Quality and Safety: Recent Views and Future Challenges." Foods 12, no. 12 (June 8, 2023): 2315. http://dx.doi.org/10.3390/foods12122315.
Анотація:
The increasing demand for natural, safe, and sustainable food preservation methods drove research towards the use of plant antimicrobials as an alternative to synthetic preservatives. This review article comprehensively discussed the potential applications of plant extracts, essential oils, and their compounds as antimicrobial agents in the food industry. The antimicrobial properties of several plant-derived substances against foodborne pathogens and spoilage microorganisms, along with their modes of action, factors affecting their efficacy, and potential negative sensory impacts, were presented. The review highlighted the synergistic or additive effects displayed by combinations of plant antimicrobials, as well as the successful integration of plant extracts with food technologies ensuring an improved hurdle effect, which can enhance food safety and shelf life. The review likewise emphasized the need for further research in fields such as mode of action, optimized formulations, sensory properties, safety assessment, regulatory aspects, eco-friendly production methods, and consumer education. By addressing these gaps, plant antimicrobials can pave the way for more effective, safe, and sustainable food preservation strategies in the future.
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Merkl, R., I. Hrádková, V. Filip, and J. Šmidrkal. "Antimicrobial and antioxidant properties of phenolic acids alkyl esters." Czech Journal of Food Sciences 28, No. 4 (September 6, 2010): 275–79. http://dx.doi.org/10.17221/132/2010-cjfs.
Анотація:
Some phenolic acids alkyl esters (methyl, ethyl, propyl, butyl and hexyl) and determine their antioxidant and antimicrobial activities were prepared. The antimicrobial activity against the tested microorganisms Escherichia coli DMF 7503, Bacillus cereus DMF 2001, Listeria monocytogenes DMF 5776, Fusarium culmorum DMF 0103, and Saccharomyces cerevisiae DMF 1017 was investigated and expressed by minimum inhibitory concentration (MIC) in the range of 1.2–20mM. The inhibitory activity of phenolic acids butyl esters was found to be higher than that of methyl esters (MIC below 1.25mM). The antioxidant activity of the selected phenolic acids alkyl esters was investigated by Rancimat method. The esters of 3,4-dihydroxyphenolic acids (protocatechuic and caffeic acids) exhibited higher antioxidant activities in comparison with the respective phenolic acids. The highest antioxidant activity was found in the case of caffeic alkyl esters.
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Rani, Sushma, and Vivek Singh. "Antimicrobial Property of Peach Leaves Against Washing." Journal of National Development 31, no. 1 (July 1, 2018): 70–74. http://dx.doi.org/10.29070/31/57438.
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Alotaibi, Areej M., Nasser B. Alsaleh, Alanoud T. Aljasham, Essam A. Tawfik, Mohammed M. Almutairi, Mohammed A. Assiri, Musaed Alkholief, and Mashal M. Almutairi. "Silver Nanoparticle-Based Combinations with Antimicrobial Agents against Antimicrobial-Resistant Clinical Isolates." Antibiotics 11, no. 9 (September 8, 2022): 1219. http://dx.doi.org/10.3390/antibiotics11091219.
Анотація:
The increasing prevalence of antimicrobial-resistant (AMR) bacteria along with the limited development of antimicrobials warrant investigating novel antimicrobial modalities. Emerging inorganic engineered nanomaterials (ENMs), most notably silver nanoparticles (AgNPs), have demonstrated superior antimicrobial properties. However, AgNPs, particularly those of small size, could exert overt toxicity to mammalian cells. This study investigated whether combining AgNPs and conventional antimicrobials would produce a synergistic response and determined the optimal and safe minimum inhibitory concentration (MIC) range against several wild-type Gram-positive and -negative strains and three different clinical isolates of AMR Klebsiella pneumoniae. Furthermore, the cytotoxicity of the synergistic combinations was assessed in a human hepatocyte model. The results showed that the AgNPs (15–25 nm) were effective against Gram-negative bacteria (MIC of 16–128 µg/mL) but not Gram-positive strains (MIC of 256 µg/mL). Both wild-type and AMR K. pneumoniae had similar MIC values following exposure to AgNPs. Importantly, co-exposure to combinations of AgNPs and antimicrobial agents, including kanamycin, colistin, rifampicin, and vancomycin, displayed synergy against both wild-type and AMR K. pneumoniae isolates (except for vancomycin against AMR strain I). Notably, the tested combinations demonstrated no to minimal toxicity against hepatocytes. Altogether, this study indicates the potential of combining AgNPs with conventional antimicrobials to overcome AMR bacteria.
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Abedini, Ehsan, Ehsaneh Khodadadi, Elham Zeinalzadeh, Seyyed Reza Moaddab, Mohammad Asgharzadeh, Bahareh Mehramouz, Sounkalo Dao, and Hossein Samadi Kafil. "A Comprehensive Study on the Antimicrobial Properties of Resveratrol as an Alternative Therapy." Evidence-Based Complementary and Alternative Medicine 2021 (March 16, 2021): 1–15. http://dx.doi.org/10.1155/2021/8866311.
Анотація:
Resveratrol is a polyphenolic antioxidant whose possible health benefits include anticarcinogenic, antiaging, and antimicrobial properties that have gained significant attention. The compound is well accepted by individuals and has been commonly used as a nutraceutical in recent decades. Its widespread usage makes it essential to study as a single agent as well as in combination with traditional prescription antibiotics as regards to antimicrobial properties. Resveratrol demonstrates the action of antimicrobials against a remarkable bacterial diversity, viruses, and fungus. This report explains resveratrol as an all-natural antimicrobial representative. It may modify the bacterial virulence qualities resulting in decreased toxic substance production, biofilm inhibition, motility reduction, and quorum sensing disturbance. Moreover, in conjunction with standard antibiotics, resveratrol improves aminoglycoside efficacy versus Staphylococcus aureus, while it antagonizes the deadly function of fluoroquinolones against S. aureus and also Escherichia coli. The present study aimed to thoroughly review and study the antimicrobial potency of resveratrol, expected to help researchers pave the way for solving antimicrobial resistance.
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Subakaeva, Evgenia, Pavel Zelenikhin, Evgenia Sokolova, Arina Pergat, Yulia Aleksandrova, Dmitriy Shurpik, and Ivan Stoikov. "The Synthesis and Antibacterial Properties of Pillar[5]arene with Streptocide Fragments." Pharmaceutics 15, no. 12 (November 23, 2023): 2660. http://dx.doi.org/10.3390/pharmaceutics15122660.
Анотація:
The growing problem of bacterial resistance to antimicrobials actualizes the development of new approaches to solve this challenge. Supramolecular chemistry tools can overcome the limited bacterial resistance and side effects of classical sulfonamides that hinder their use in therapy. Here, we synthesized a number of pillar[5]arenes functionalized with different substituents, determined their ability to self-association using DLS, and characterized antimicrobial properties against S. typhimurium, K. pneumoniae, P. aeruginosa, S. epidermidis, S. aureus via a resazurin test. Biofilm prevention concentration was calculated for an agent with established antimicrobial activity by the crystal–violet staining method. We evaluated the mutagenicity of the macrocycle using the Ames test and its ability to affect the viability of A549 and LEK cells in the MTT-test. It was shown that macrocycle functionalized with sulfonamide residues exhibited antimicrobial activity an order higher than pure streptocide and also revealed the ability to prevent biofilm formation of S. aureus and P. aeruginosa. The compound did not show mutagenic activity and exhibited low toxicity to eukaryotic cells. The obtained results allow considering modification of the macrocyclic platforms with classic antimicrobials as an opportunity to give them a “second life” and return to practice with improved properties.
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Prado, Júlio César Sousa, Guilherme Mendes Prado, Francisca Lidiane Linhares Aguiar, Andrea Maria Neves, Joice Farias do Nascimento, Flávia Oliveira Monteiro da Silva Abreu, and Raquel Oliveira dos Santos Fontenelle. "Nanoemulsions of plant-based bioactive compounds with antimicrobial applications: a review." Ciência e Natura 46 (April 10, 2024): e74325. http://dx.doi.org/10.5902/2179460x74325.
Анотація:
The search for alternative antimicrobial agents is attracting increasing scientific interest. Natural products of plant origin are sources of several substances with proven biological activities, including antimicrobial activity. The encapsulation of these products in the form of a nanoemulsion seeks to overcome problems inherent to these products, such as instability and degradation. Based on these considerations, we carried out a bibliographical survey of nanoemulsions produced from plant-derived substances, such as essential oils and extracts, with antimicrobial potential, focusing on antibacterial, antifungal and antiviral activities. Articles and documents published in scientifically relevant journals, as well as keywords classified from Health Sciences Descriptors, were used. All documents relevant to this search reported that nanoemulsions loaded with essential oils and plant extracts from different botanical species had in vitro antimicrobial activity against different microorganisms of medical importance, in addition to enhancing the antimicrobial effects of these bioproducts. Therefore, nanostructured antimicrobials with essential oils and plant extracts can be considered treatment options for microbial diseases: due to their physicochemical properties, they act as better delivery vehicles for natural products with good bioavailability, by reducing toxicity and prolonging the useful life of these natural antimicrobials, thus enhancing treatment for infectious human diseases.
28
Wickramanayake, M. V. K. S., P. M. Kumarage, Sana Majeed, and G. J. Heo. "An overview of the antimicrobial activity of some essential oils against fish pathogenic bacteria." Veterinary Integrative Sciences 21, no. 1 (November 7, 2022): 99–119. http://dx.doi.org/10.12982/vis.2023.009.
Анотація:
Plant-derived essential oils as an alternative treatment method for antimicrobial-resistant bacteria have gained interest over the past few decades, particularly in the food and aquaculture industry. Essential oil is considered as a natural, cost-effective compound with a minimum impact on the environment. Studies have suggested the use of essential oils in the treatment and/or prevention of infectious diseases in fish may be a cost-effective alternative to synthetic antimicrobials. In addition to that,hundreds of different chemical profiles have been identified in essential oils. Particularly, in the same essential oil. In contrast to the synthetic antimicrobials that have unique chemical compositions between every product belonging to the same drug, the same essential oil may not perform unique antimicrobial activity every time. Therefore, more studies and concluded data are required for the effective usage of essential oils as an alternative to antimicrobial agents. In this review, we have summarized the studies about the several active essential oils that are known and tested against fish pathogenic bacteria because of their antimicrobial properties
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Orchard, Ané, and Sandy van Vuuren. "Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–92. http://dx.doi.org/10.1155/2017/4517971.
Анотація:
Essential oils are one of the most notorious natural products used for medical purposes. Combined with their popular use in dermatology, their availability, and the development of antimicrobial resistance, commercial essential oils are often an option for therapy. At least 90 essential oils can be identified as being recommended for dermatological use, with at least 1500 combinations. This review explores the fundamental knowledge available on the antimicrobial properties against pathogens responsible for dermatological infections and compares the scientific evidence to what is recommended for use in common layman’s literature. Also included is a review of combinations with other essential oils and antimicrobials. The minimum inhibitory concentration dilution method is the preferred means of determining antimicrobial activity. While dermatological skin pathogens such asStaphylococcus aureushave been well studied, other pathogens such asStreptococcus pyogenes,Propionibacterium acnes,Haemophilus influenzae, andBrevibacteriumspecies have been sorely neglected. Combination studies incorporating oil blends, as well as interactions with conventional antimicrobials, have shown that mostly synergy is reported. Very few viral studies of relevance to the skin have been made. Encouragement is made for further research into essential oil combinations with other essential oils, antimicrobials, and carrier oils.
30
Vanoye Eligi, Maximiliano, Blanca del Rosario Martín Canché, José Carlos Pech Ferrer, José Alfredo García Vela, and Katiuska Alejandra Torres Sauri. "Capacidad Antimicrobiana de Cinco Aceites Esenciales de Plantas Aromáticas en Escárcega, Campeche, México." European Scientific Journal, ESJ 18, no. 17 (May 31, 2022): 197. http://dx.doi.org/10.19044/esj.2022.v18n17p197.
Анотація:
Los aceites esenciales son mejor conocidos como fracciones líquidas volátiles generalmente destilables por arrastre con vapor de agua, estos son utilizados como alternativa de conservación de los alimentos debido a sus propiedades antimicrobianas que inhiben el crecimiento de cualquier agente contaminante. Por ello, el objetivo del trabajo fue evaluar la capacidad antimicrobiana de cinco aceites esenciales de especies aromáticas para la conservación de las frutas y verduras expuestas a condiciones ambientales propicias para la propagación de microorganismos. Para el logro de este trabajo de investigación se seleccionaron cinco especies de plantas aromáticas; pimienta (Piper nigrum L. 1753), ruda (Ruta graveolens L. 1753), zacate limón (Cymbopogon citratus (DC.) Stapf. 1906), zorrilla (Cestrum racemosum Ruiz and Pav. 1799) y albahaca (Ocimum basilicum L. 1753), en el municipio de Escárcega, Campeche, México. La extracción de aceites esenciales se realizó a partir de las hojas valorando su capacidad antimicrobiana (desvío microbiano). Los resultados demostraron que cuatro de las cinco especies presentan actividad antimicrobiana principalmente; los aceites de albahaca y zorrilla en concentraciones de 1:5 y 1:10, inhibieron el crecimiento de microorganismos presentando un comportamiento antimicrobiano frente a las coliformes totales. Para el caso del zacate limón y la albahaca, ambos presentaron actividad fungicida, debido a la nula presencia de hongos y levaduras tras su aplicación. A diferencia de la ruda que en concentraciones menores no se recomienda para conservación de los alimentos, debido a que presentó crecimiento de microorganismos, siendo recomendada sólo para uso fungicida. Por tal motivo, las diluciones aplicadas con función antimicrobiana utilizadas para el recubrimiento de los alimentos son efectivas en altas concentraciones, según el análisis visual de la capacidad antimicrobiana en frutas y verduras, para el control de propagación microbiana. Por lo anterior se sugiere el uso de estos aceites esenciales en el control del crecimiento de los microorganismos expuestos a condiciones ambientales, propiciando la vida en anaquel de estos alimentos.
Essential oils are better known as volatile liquid fractions, generally distillable by steam distillation, these are used as an alternative for food preservation due to their antimicrobial properties that inhibit the growth of any contaminating agent. Therefore, the objective of the work was to evaluate the antimicrobial capacity of five essential oils of aromatic species for the conservation of fruits and vegetables exposed to environmental conditions conducive to the propagation of microorganisms. For the achievement of this research work, five species of aromatic plants were selected; pepper (Piper nigrum L. 1753), rue (Ruta graveolens L. 1753), lemongrass (Cymbopogon citratus (DC.) Stapf. 1906), skunk (Cestrum racemosum Ruiz and Pav. 1799) and basil (Ocimum basilicum L. 1753), in the municipality of Escarcega, Campeche, Mexico. The extraction of essential oils was carried out from the leaves, assessing their antimicrobial capacity (microbial diversion). The results showed that four of the five species present mainly antimicrobial activity; basil and zorrilla oils at concentrations of 1:5 and 1:10, inhibited the growth of microorganisms, presenting antimicrobial behavior against total coliforms. In the case of lemongrass and basil, both presented fungicidal activity, due to the null presence of fungi and yeasts after their application. For this reason, the applied dilutions with antimicrobial function used for the coating of foods are effective in high concentrations, according to the visual analysis of the antimicrobial capacity in fruits and vegetables, for the control of microbial propagation. Therefore, the use of these essential oils is suggested to control the growth of microorganisms exposed to environmental conditions, favoring the shelf life of these foods.
31
He, Zengguo, Duygu Kisla, Liwen Zhang, Chunhua Yuan, Kari B. Green-Church, and Ahmed E. Yousef. "Isolation and Identification of a Paenibacillus polymyxa Strain That Coproduces a Novel Lantibiotic and Polymyxin." Applied and Environmental Microbiology 73, no. 1 (October 27, 2006): 168–78. http://dx.doi.org/10.1128/aem.02023-06.
Анотація:
ABSTRACT A new bacterial strain, displaying potent antimicrobial properties against gram-negative and gram-positive pathogenic bacteria, was isolated from food. Based on its phenotypical and biochemical properties as well as its 16S rRNA gene sequence, the bacterium was identified as Paenibacillus polymyxa and it was designated as strain OSY-DF. The antimicrobials produced by this strain were isolated from the fermentation broth and subsequently analyzed by liquid chromatography-mass spectrometry. Two antimicrobials were found: a known antibiotic, polymyxin E1, which is active against gram-negative bacteria, and an unknown 2,983-Da compound showing activity against gram-positive bacteria. The latter was purified to homogeneity, and its antimicrobial potency and proteinaceous nature were confirmed. The antimicrobial peptide, designated paenibacillin, is active against a broad range of food-borne pathogenic and spoilage bacteria, including Bacillus spp., Clostridium sporogenes, Lactobacillus spp., Lactococcus lactis, Leuconostoc mesenteroides, Listeria spp., Pediococcus cerevisiae, Staphylococcus aureus, and Streptococcus agalactiae. Furthermore, it possesses the physico-chemical properties of an ideal antimicrobial agent in terms of water solubility, thermal resistance, and stability against acid/alkali (pH 2.0 to 9.0) treatment. Edman degradation, mass spectroscopy, and nuclear magnetic resonance were used to sequence native and chemically modified paenibacillin. While details of the tentative sequence need to be elucidated in future work, the peptide was unequivocally characterized as a novel lantibiotic, with a high degree of posttranslational modifications. The coproduction of polymyxin E1 and a lantibiotic is a finding that has not been reported earlier. The new strain and associated peptide are potentially useful in food and medical applications.
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Cesaro, Angela, Rosa Gaglione, Marco Chino, Maria De Luca, Rocco Di Girolamo, Angelina Lombardi, Rosanna Filosa, and Angela Arciello. "Novel Retro-Inverso Peptide Antibiotic Efficiently Released by a Responsive Hydrogel-Based System." Biomedicines 10, no. 6 (June 2, 2022): 1301. http://dx.doi.org/10.3390/biomedicines10061301.
Анотація:
Topical antimicrobial treatments are often ineffective on recalcitrant and resistant skin infections. This necessitates the design of antimicrobials that are less susceptible to resistance mechanisms, as well as the development of appropriate delivery systems. These two issues represent a great challenge for researchers in pharmaceutical and drug discovery fields. Here, we defined the therapeutic properties of a novel peptidomimetic inspired by an antimicrobial sequence encrypted in human apolipoprotein B. The peptidomimetic was found to exhibit antimicrobial and anti-biofilm properties at concentration values ranging from 2.5 to 20 µmol L−1, to be biocompatible toward human skin cell lines, and to protect human keratinocytes from bacterial infections being able to induce a reduction of bacterial units by two or even four orders of magnitude with respect to untreated samples. Based on these promising results, a hyaluronic-acid-based hydrogel was devised to encapsulate and to specifically deliver the selected antimicrobial agent to the site of infection. The developed hydrogel-based system represents a promising, effective therapeutic option by combining the mechanical properties of the hyaluronic acid polymer with the anti-infective activity of the antimicrobial peptidomimetic, thus opening novel perspectives in the treatment of skin infections.
33
Orsi, Mario, Massimo G. Noro, and Jonathan W. Essex. "Dual-resolution molecular dynamics simulation of antimicrobials in biomembranes." Journal of The Royal Society Interface 8, no. 59 (December 3, 2010): 826–41. http://dx.doi.org/10.1098/rsif.2010.0541.
Анотація:
Triclocarban and triclosan, two potent antibacterial molecules present in many consumer products, have been subject to growing debate on a number of issues, particularly in relation to their possible role in causing microbial resistance. In this computational study, we present molecular-level insights into the interaction between these antimicrobial agents and hydrated phospholipid bilayers (taken as a simple model for the cell membrane). Simulations are conducted by a novel ‘dual-resolution’ molecular dynamics approach which combines accuracy with efficiency: the antimicrobials, modelled atomistically, are mixed with simplified (coarse-grain) models of lipids and water. A first set of calculations is run to study the antimicrobials' transfer free energies and orientations as a function of depth inside the membrane. Both molecules are predicted to preferentially accumulate in the lipid headgroup–glycerol region; this finding, which reproduces corresponding experimental data, is also discussed in terms of a general relation between solute partitioning and the intramembrane distribution of pressure. A second set of runs involves membranes incorporated with different molar concentrations of antimicrobial molecules (up to one antimicrobial per two lipids). We study the effects induced on fundamental membrane properties, such as the electron density, lateral pressure and electrical potential profiles. In particular, the analysis of the spontaneous curvature indicates that increasing antimicrobial concentrations promote a ‘destabilizing’ tendency towards non-bilayer phases, as observed experimentally. The antimicrobials' influence on the self-assembly process is also investigated. The significance of our results in the context of current theories of antimicrobial action is discussed.
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Queiroga, Maria Cristina, Marta Laranjo, Nara Andrade, Mariana Marques, Ana Rodrigues Costa, and Célia Maria Antunes. "Antimicrobial, Antibiofilm and Toxicological Assessment of Propolis." Antibiotics 12, no. 2 (February 8, 2023): 347. http://dx.doi.org/10.3390/antibiotics12020347.
Анотація:
Antimicrobial resistance is a serious problem for the control of infections and infectious diseases. Propolis is a substance produced by honeybees with antimicrobial and antibiofilm properties. To consider propolis as an alternative to the use of antimicrobials for infection control, we assessed its antimicrobial and antibiofilm activities. To assess propolis for topical medical use, toxicological studies were also performed. A Portuguese 70% propolis ethanolic extract was chemically evaluated and studied for antimicrobial activity on staphylococcal field isolates (n = 137) and antibiofilm action (n = 45). Cell toxicological assessment was performed using keratinocytes and fibroblasts. Pinobanksin, chrysin, acacetin, apigenin, pinocembrin, and kaempferol-dimethyl-ether were detected. All 137 isolates were susceptible to 6.68 mg/mL or lower propolis concentration (80% isolates were susceptible to <1 mg/mL). The mean percentage of biofilm inhibition was 71%, and biofilm disruption was 88.5%. Propolis (<1 mg/mL) was well-tolerated by fibroblasts and moderately tolerated by keratinocytes. The combined antimicrobial and antibiofilm effect of propolis, together with its low toxicity to connective tissue and epithelial cells, suggests a good applicability for topical antibacterial treatment. Therefore, propolis seems to be a good alternative to antimicrobials for the treatment of infections with Staphylococcus spp. that deserves to be evaluated in vivo.
35
Backx, Bianca P., Mayara S. dos Santos, Otávio A. L. dos Santos, and Sérgio A. Filho. "The Role of Biosynthesized Silver Nanoparticles in Antimicrobial Mechanisms." Current Pharmaceutical Biotechnology 22, no. 6 (May 31, 2021): 762–72. http://dx.doi.org/10.2174/1389201022666210202143755.
Анотація:
Nanotechnology is an area of science in which new materials are developed. The correlation between nanotechnology and microbiology is essential for the development of new drugs and vaccines. The main advantage of combining these areas is to associate the latest technology in order to obtain new ways for solving problems related to microorganisms. This review seeks to investigate nanoparticle formation's antimicrobial properties, primarily when connected to the green synthesis of silver nanoparticles. The development of new sustainable methods for nanoparticle production has been instrumental in designing alternative, non-toxic, energy-friendly, and environmentally friendly routes. In this sense, it is necessary to study silver nanoparticles' green synthesis concerning their antimicrobial properties. Antimicrobial silver nanoparticles' mechanisms demonstrate efficiency to gram-positive bacteria, gram-negative bacteria, fungi, viruses, and parasites. However, attention is needed with the emergence of resistance to these antimicrobials. This article seeks to relate the parameters of green silver- based nanosystems with the efficiency of antimicrobial activity.
36
Celikel, N., and G. Kavas. "Antimicrobial properties of some essential oils against some pathogenic microorganisms." Czech Journal of Food Sciences 26, No. 3 (June 11, 2008): 174–81. http://dx.doi.org/10.17221/1603-cjfs.
Анотація:
Investigations were carried out to assess the efficiency of five plant essential oils: thyme, myrtle, laurel, sage, and orange oils as natural food preservatives. The effect of the plant essential oils against <i>Escherichia coli</i>, <i>Listeria monocytogenes</i>, <i>Staphylococcus aureus</i> and <i>Candida albicans</i> at concentrations of 5–20 µl/disk (diameter 6 mm) and 0.5–3% (v/v) was studied in agar diffusion test medium and milk medium. The essential oils of these extracts exhibited markedly antibacterial and bacteriostatic activity, with thyme showing the highest inhibition and orange the lowest. However, with thyme extract, high inhibitory activity was observed for all tested concentrations, <i>L. monocytogenes</i> showed less sensitivity towards essential oil extracts.
37
TINTINO, Saulo Relison, Abel Alves De Carvalho NETO, Irwin R. A. MENEZES, Cícera Datiane de M. OLIVEIRA, and Henrique D. M. COUTINHO. "ACTIVIDADE ANTIMICROBIANA E EFEITO COMBIANDO SOBRE DROGAS ANTIFÚNGICAS Y ANTIBACTERIANAS DO FRUTO DE Morinda citrifolia L." Acta Biológica Colombiana 20, no. 3 (July 24, 2015): 193–200. http://dx.doi.org/10.15446/abc.v20n3.45601.
Анотація:
<p>O aparecimento de micro-organismos resistentes e a toxicidade associada aos fármacos antimicrobianos aumentam a necessidade de pesquisas por novos princípios ativos. <em>Morinda citrifolia </em>L., uma planta frutífera utilizada popularmente como antibacteriano e com diversos outros usos farmacológicos. Possui diversos metabólitos primários e secundários, principalmente flavonóides, triterpenóides e alcalóides. O presente trabalho visou testar o potencial antimicrobiano e modulador dos extratos do seu fruto. Os extratos do fruto foram testados quanto ao seu efeito antimicrobiano e em combinação com antibacterianos e antifúngicos contra microrganismos patógenos pelo método de microdiluição em caldo. Observou-se que as associações entre antibióticos e extratos mostraram resultados com relevância clínica diante dos testes com bactérias <em>Pseudomonas aeruginosa</em> e <em>Escherichia coli</em>. </p><p><strong>Actividad antimicrobiana y efecto</strong> <strong>combinado sobre medicamentos antifúngicos y antibacterianos del fruto de <em>Morinda citrifolia</em> L.</strong></p><p>La aparición de microorganismos resistentes y la toxicidad asociada a los antimicrobianos aumenta la necesidad de investigar nuevos principios activos. <em>Morinda citrifolia</em> L., es una planta fructífera utilizada popularmente como antibacteriano y con otros diversos usos farmacológicos. Posee diversos metabolitos primarios y secundarios, principalmente flavonoides, triterpenoides y alcaloides. Este estudio tuvo como objetivo ensayar la potencial actividad antimicrobiana y moduladora de los extractos obtenidos de su fruta. Los extractos de las frutas fueron testados tanto para determinar el efecto antimicrobiano como también utilizándolo en combinación con agentes antibacterianos y antifúngicos contra microorganismos patógenos, por el método de microdilución en caldo. Se observó que la asociación entre antibióticos y extractos dió resultados clínicamente significativos en pruebas con bacterias <em>Pseudomonas aeruginosa </em>y <em>Escherichia coli</em>. </p><p><strong>Antimicrobial Activity and Combined Effects on Antifungal and Antibacterial Drugs the Fruit of <em>Morinda citrifolia </em>L.</strong></p><p>The rising of the drug resistant microrganisms and the toxicity related with the antimicrobial drugs enhances the necessity about the search of new bioactive compounds. <em>Morinda citrifolia </em>L. is a fruit tree traditionally used as antibacterial and with several other pharmacological properties. This plant presents several phytocompounds as flavonoids, alkaloids and triterpenes. The objective of this work was assay the antimicrobial and modulatory potential of the fruit extract. The extract was assayed alone and associated with antibiotics and antifungals against pathogenic microrganisms using the microdilution assay. The results demonstrated that the association between extract and antimicrobial drugs resulted in a potentiation of the drug activity clinically relevant against <em>Pseudomonas aeruginosa</em> and <em>Escherichia coli</em>.</p>
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Kamal, Nazia, and William M. Shafer. "Biologic Activities of the TolC-Like Protein of Neisseria meningitidis as Assessed by Functional Complementation in Escherichia coli." Antimicrobial Agents and Chemotherapy 54, no. 1 (November 2, 2009): 506–8. http://dx.doi.org/10.1128/aac.01168-09.
Анотація:
ABSTRACT Neisseria meningitidis can produce a TolC-like protein needed for secretion of FrpC but not efflux of antimicrobials. We now report that expression of the meningococcal tolC gene in a TolC-deficient strain of Escherichia coli can restore properties of α-hemolysis and antimicrobial resistance known to involve efflux pumps.
39
Oliveira, Gabriel da Silva, Concepta McManus, Heloisa Alves de Figueiredo Sousa, Pedro Henrique Gomes de Sá Santos, and Vinícius Machado dos Santos. "A Mini-Review of the Main Effects of Essential Oils from Citrus aurantifolia, Ocimum basilicum, and Allium sativum as Safe Antimicrobial Activity in Poultry." Animals 14, no. 3 (January 25, 2024): 382. http://dx.doi.org/10.3390/ani14030382.
Анотація:
Poultry production is accompanied by the use of antimicrobial agents because no production step is free of microorganisms. In the absence of antimicrobial treatments with synthetic drugs, essential oils are among the most cited natural alternatives used to prevent and treat microbial contamination in poultry. Although there are several studies on the antimicrobial properties of essential oils, there is still no review that simultaneously compiles information on the leading antimicrobial role of essential oils from Citrus aurantifolia (CAEO), Ocimum basilicum (OBEO), and Allium sativum (ASEO) in poultry. Awareness of the antimicrobial role of these substances opens the door to encouraging their use in natural antimicrobial protocols and discouraging harmful synthetics in poultry. This review aimed to compile information on applying CAEO, OBEO, and ASEO as antimicrobials in poultry farming. The available literature suggests that these essential oils can proportionately align with the poultry industry’s demands for microbiologically safe food products.
40
Haj Bloukh, Samir, Zehra Edis, Hamid Abu Sara, and Mustafa Ameen Alhamaidah. "Antimicrobial Properties of Lepidium sativum L. Facilitated Silver Nanoparticles." Pharmaceutics 13, no. 9 (August 27, 2021): 1352. http://dx.doi.org/10.3390/pharmaceutics13091352.
Анотація:
Antibiotic resistance toward commonly used medicinal drugs is a dangerously growing threat to our existence. Plants are naturally equipped with a spectrum of biomolecules and metabolites with important biological activities. These natural compounds constitute a treasure in the fight against multidrug-resistant microorganisms. The development of plant-based antimicrobials through green synthesis may deliver alternatives to common drugs. Lepidium sativum L. (LS) is widely available throughout the world as a fast-growing herb known as garden cress. LS seed oil is interesting due to its antimicrobial, antioxidant, and anti-inflammatory activities. Nanotechnology offers a plethora of applications in the health sector. Silver nanoparticles (AgNP) are used due to their antimicrobial properties. We combined LS and AgNP to prevent microbial resistance through plant-based synergistic mechanisms within the nanomaterial. AgNP were prepared by a facile one-pot synthesis through plant-biomolecules-induced reduction of silver nitrate via a green method. The phytochemicals in the aqueous LS extract act as reducing, capping, and stabilizing agents of AgNP. The composition of the LS-AgNP biohybrids was confirmed by analytical methods. Antimicrobial testing against 10 reference strains of pathogens exhibited excellent to intermediate antimicrobial activity. The bio-nanohybrid LS-AgNP has potential uses as a broad-spectrum microbicide, disinfectant, and wound care product.
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Silva, Osmar N., Marcelo D. T. Torres, Jicong Cao, Elaine S. F. Alves, Leticia V. Rodrigues, Jarbas M. Resende, Luciano M. Lião, et al. "Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties." Proceedings of the National Academy of Sciences 117, no. 43 (October 12, 2020): 26936–45. http://dx.doi.org/10.1073/pnas.2012379117.
Анотація:
Novel antibiotics are urgently needed to combat multidrug-resistant pathogens. Venoms represent previously untapped sources of novel drugs. Here we repurposed mastoparan-L, the toxic active principle derived from the venom of the wasp Vespula lewisii, into synthetic antimicrobials. We engineered within its N terminus a motif conserved among natural peptides with potent immunomodulatory and antimicrobial activities. The resulting peptide, mast-MO, adopted an α-helical structure as determined by NMR, exhibited increased antibacterial properties comparable to standard-of-care antibiotics both in vitro and in vivo, and potentiated the activity of different classes of antibiotics. Mechanism-of-action studies revealed that mast-MO targets bacteria by rapidly permeabilizing their outer membrane. In animal models, the peptide displayed direct antimicrobial activity, led to enhanced ability to attract leukocytes to the infection site, and was able to control inflammation. Permutation studies depleted the remaining toxicity of mast-MO toward human cells, yielding derivatives with antiinfective activity in animals. We demonstrate a rational design strategy for repurposing venoms into promising antimicrobials.
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Antone, Unigunde, Inga Ciprovica, Maksims Zolovs, Rita Scerbaka, and Janis Liepins. "Propionic Acid Fermentation—Study of Substrates, Strains, and Antimicrobial Properties." Fermentation 9, no. 1 (December 28, 2022): 26. http://dx.doi.org/10.3390/fermentation9010026.
Анотація:
Since milk whey is an abundant dairy by-product and a significant threat to the environment, its utilization is of great interest. The study compares valorization of lactose and lactates—the main carbon sources of whey—by fermentation—an environmentally friendly process. Antimicrobials released during fermentation by food-grade bacteria can help increase the microbiological safety of food. Propionic acid—a strong antimicrobial—is obtained mainly by the petrochemical route, yet there is increasing interest in its synthesis in biotechnological pathway. Five strains of propionic acid bacteria (Acidipropionibacterium acidipropionici, Propionibacterium cyclohexanicum, Propionibacterium freudenreichii, Acidipropionibacterium jensenii and Acidipropionibacterium thoenii) were investigated for their ability to produce organic acids and biomass using Na lactate or lactose as carbon sources. Selected fermentates were investigated for their antimicrobial efficacy during in vitro studies with foodborne pathogens: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. Results confirm that the production of acids and biomass is considerably influenced by the added carbon source. The tested fermentates have strong and specific antimicrobial activity against Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. In addition, inhibition of Staphylococcus aureus and Klebsiella pneumonia depends on the activity of produced bacteriocins. The article also discusses the possibility of increasing the antimicrobial activity of fermentates by acidification.
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Kozłowski, Grzegorz, and Jean P. Métraux. "Antifungal properties of Norway spruce (Picea abies (L.) Karst.) seedling homogenates." Acta Societatis Botanicorum Poloniae 68, no. 3 (2014): 191–95. http://dx.doi.org/10.5586/asbp.1999.025.
Анотація:
The presence of antimicrobials in root, hypocotyl and cotyledon homogenates of Norway spruce was studied using in vitro assays with soil-borne pathogens. For the studies presented here Norway spruce (<em>Picea abies</em> (L.) Karst.) as a typical host and forest tree and <em>Pythium</em> as a typical soil-bome pathogen were used. The highly virulent species <em>Pythium ultimum</em> and the less virulent species <em>Pythium irregulare</em> were chosen for all experiments. They are both the causal agents of damping-off disease, which can affect plants at a very early stage. The strongest antimicrobial effect was observed using medium prepared from older seedlings and containing extracts from cotyledons. The influence of various treatments on antimicrobials accumulation in spruce extracts was also tested. Seed coat shedding was observed to affect mortality of <em>Picea abies</em> seedlings infected by <em>Pythium</em>. Seedlings which had shed their seed coats were more resistant to <em>Pythium</em> attack. This phenomenon could be correlated with antimicrobial production in well developed cotyledons.
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Xin, Bingyue, Jinshui Zheng, Ziya Xu, Congzhi Li, Lifang Ruan, Donghai Peng, and Ming Sun. "Three Novel Lantibiotics, Ticins A1, A3, and A4, Have Extremely Stable Properties and Are Promising Food Biopreservatives." Applied and Environmental Microbiology 81, no. 20 (July 31, 2015): 6964–72. http://dx.doi.org/10.1128/aem.01851-15.
Анотація:
ABSTRACTLantibiotics are antimicrobial peptides with potential applications as the next generation of antimicrobials in the food industry and/or the pharmaceutical industry. Nisin has successfully been used as a food preservative for over 40 years, but its major drawback is its limited stability under neutral and alkaline pH conditions. To identify alternatives with better biochemical properties, we screened more than 100 strains of theBacillus cereusgroup. Three novel lantibiotics, ticins A1 (4,062.98 Da), A3 (4,048.96 Da), and A4 (4,063.02 Da), which were highly thermostable (121°C for 30 min) and extremely pH tolerant (pH 2.0 to 9.0), were identified inBacillus thuringiensisBMB3201. They all showed potent antimicrobial activities against all tested Gram-positive bacteria and greater activities than those of nisin A againstBacillus cereusandListeria monocytogenes, two important foodborne pathogens. These three novel lantibiotics, with their extremely stable properties and potent antimicrobial activities, have the potential for use as biopreservatives.
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Paquette, Sarah-Jo, and Tim Reuter. "Escherichia coli: Physiological Clues Which Turn On the Synthesis of Antimicrobial Molecules." Veterinary Sciences 7, no. 4 (November 21, 2020): 184. http://dx.doi.org/10.3390/vetsci7040184.
Анотація:
Zoonotic pathogens, like Shiga toxin-producing Escherichia coli (STEC) are a food safety and health risk. To battle the increasing emergence of virulent microbes, novel mitigation strategies are needed. One strategy being considered to combat pathogens is antimicrobial compounds produced by microbes, coined microcins. However, effectors for microcin production are poorly understood, particularly in the context of complex physiological responses along the gastro-intestinal tract (GIT). Previously, we identified an E. coli competitor capable of producing a strong diffusible antimicrobial with microcin-associated characteristics. Our objective was to examine how molecule production of this competitor is affected by physiological properties associated with the GIT, namely the effects of carbon source, bile salt concentration and growth phase. Using previously described liquid- and agar-based assays determined that carbon sources do not affect antimicrobial production of E. coli O103F. However, bile salt concentrations affected production significantly, suggesting that E. coli O103F uses cues along the GIT to modulate the expression of antimicrobial production. Furthermore, E. coli O103F produces the molecule during the exponential phase, contrary to most microcins identified to date. The results underscored the importance of experimental design to identify producers of antimicrobials. To detect antimicrobials, conventional microbiological methods can be a starting point, but not the gold standard.
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Cabral, Eduarda M., Márcia Oliveira, Julie R. M. Mondala, James Curtin, Brijesh K. Tiwari, and Marco Garcia-Vaquero. "Antimicrobials from Seaweeds for Food Applications." Marine Drugs 19, no. 4 (April 11, 2021): 211. http://dx.doi.org/10.3390/md19040211.
Анотація:
The exponential growth of emerging multidrug-resistant microorganisms, including foodborne pathogens affecting the shelf-life and quality of foods, has recently increased the needs of the food industry to search for novel, natural and eco-friendly antimicrobial agents. Macroalgae are a bio-diverse group distributed worldwide, known to produce multiple compounds of diverse chemical nature, different to those produced by terrestrial plants. These novel compounds have shown promising health benefits when incorporated into foods, including antimicrobial properties. This review aims to provide an overview of the general methods and novel compounds with antimicrobial properties recently isolated and characterized from macroalgae, emphasizing the molecular pathways of their antimicrobial mechanisms of action. The current scientific evidence on the use of macroalgae or macroalgal extracts to increase the shelf-life of foods and prevent the development of foodborne pathogens in real food products and their influence on the sensory attributes of multiple foods (i.e., meat, dairy, beverages, fish and bakery products) will also be discussed, together with the main challenges and future trends of the use of marine natural products as antimicrobials.
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Hong, HeeJue, Lucy Sloan, Deepak Saxena, and David A. Scott. "The Antimicrobial Properties of Cannabis and Cannabis-Derived Compounds and Relevance to CB2-Targeted Neurodegenerative Therapeutics." Biomedicines 10, no. 8 (August 12, 2022): 1959. http://dx.doi.org/10.3390/biomedicines10081959.
Анотація:
Cannabinoid receptor 2 (CB2) is of interest as a much-needed target for the treatment or prevention of several neurogenerative diseases. However, CB2 agonists, particularly phytocannabinoids, have been ascribed antimicrobial properties and are associated with the induction of microbiome compositional fluxes. When developing novel CB2 therapeutics, CB2 engagement and antimicrobial functions should both be considered. This review summarizes those cannabinoids and cannabis-informed molecules and preparations (CIMPs) that show promise as microbicidal agents, with a particular focus on the most recent developments. CIMP–microbe interactions and anti-microbial mechanisms are discussed, while the major knowledge gaps and barriers to translation are presented. Further research into CIMPs may proffer novel direct or adjunctive strategies to augment the currently available antimicrobial armory. The clinical promise of CIMPs as antimicrobials, however, remains unrealized. Nevertheless, the microbicidal effects ascribed to several CB2 receptor-agonists should be considered when designing therapeutic approaches for neurocognitive and other disorders, particularly in cases where such regimens are to be long-term. To this end, the potential development of CB2 agonists lacking antimicrobial properties is also discussed.
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Boparai, Jaspreet Kaur, and Pushpender Kumar Sharma. "Mini Review on Antimicrobial Peptides, Sources, Mechanism and Recent Applications." Protein & Peptide Letters 27, no. 1 (December 10, 2019): 4–16. http://dx.doi.org/10.2174/0929866526666190822165812.
Анотація:
Antimicrobial peptides in recent years have gained increased interest among scientists, health professionals and the pharmaceutical companies owing to their therapeutic potential. These are low molecular weight proteins with broad range antimicrobial and immuno modulatory activities against infectious bacteria (Gram positive and Gram negative), viruses and fungi. Inability of micro-organisms to develop resistance against most of the antimicrobial peptide has made them as an efficient product which can greatly impact the new era of antimicrobials. In addition to this these peptides also demonstrates increased efficacy, high specificity, decreased drug interaction, low toxicity, biological diversity and direct attacking properties. Pharmaceutical industries are therefore conducting appropriate clinical trials to develop these peptides as potential therapeutic drugs. More than 60 peptide drugs have already reached the market and several hundreds of novel therapeutic peptides are in preclinical and clinical development. Rational designing can be used further to modify the chemical and physical properties of existing peptides. This mini review will discuss the sources, mechanism and recent therapeutic applications of antimicrobial peptides in treatment of infectious diseases.
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S. Sangameswaran, K. G. Parthiban, P. Muniraj, C. Nandhakumar, and M. Naveen Kumar. "Antimicrobial activity of traditional formulation." World Journal of Advanced Research and Reviews 17, no. 2 (February 28, 2023): 512–16. http://dx.doi.org/10.30574/wjarr.2023.17.2.0259.
Анотація:
This study was undertaken to investigate the antimicrobial activity of traditional formulation using phyla nodiflora, Hibiscus rosa sinesis, Phyllanthus emblica, and piper nigrum plant against pathogens. cold press oil and refined oil extracts of the above plants were prepared and their antimicrobial properties were evaluated by measuring the zone of inhibition using the disk diffusion method. Various fractions showed antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, staphylococcus aureus, and antifungal activity against Aspergillus niger and Aspergillus flavus. The results indicated that all of the extracts show antimicrobial properties. The highest potential was observed in formulation 4 (phyla nodiflora leaves & cold press oil) 18 mm zone of inhibition. The cold press oil extract shows maximum inhibition against bacteria as compared to fungi. The experiment confirmed the using phyla nodiflora, Hibiscus rosa sinesis, Phyllanthus emblica, and piper nigrum oil extracts as natural antimicrobials and suggested the possibility of scalp infectious diseases caused by the test organism. The current investigation shows leaves of Phyla nodiflora have potent antimicrobial activity further study is needed to explore its full potential.
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Borgonovo, Fabio, Massimiliano Quici, Antonio Gidaro, Davide Giustivi, Dario Cattaneo, Cristina Gervasoni, Maria Calloni, et al. "Physicochemical Characteristics of Antimicrobials and Practical Recommendations for Intravenous Administration: A Systematic Review." Antibiotics 12, no. 8 (August 19, 2023): 1338. http://dx.doi.org/10.3390/antibiotics12081338.
Анотація:
Most antimicrobial drugs need an intravenous (IV) administration to achieve maximum efficacy against target pathogens. IV administration is related to complications, such as tissue infiltration and thrombo-phlebitis. This systematic review aims to provide practical recommendations about diluent, pH, osmolarity, dosage, infusion rate, vesicant properties, and phlebitis rate of the most commonly used antimicrobial drugs evaluated in randomized controlled studies (RCT) till 31 March 2023. The authors searched for available IV antimicrobial drugs in RCT in PUBMED EMBASE®, EBSCO® CINAHL®, and the Cochrane Controlled Clinical trials. Drugs’ chemical features were searched online, in drug data sheets, and in scientific papers, establishing that the drugs with a pH of <5 or >9, osmolarity >600 mOsm/L, high incidence of phlebitis reported in the literature, and vesicant drugs need the adoption of utmost caution during administration. We evaluated 931 papers; 232 studies were included. A total of 82 antimicrobials were identified. Regarding antibiotics, 37 reach the “caution” criterion, as well as seven antivirals, 10 antifungals, and three antiprotozoals. In this subgroup of antimicrobials, the correct vascular access device (VAD) selection is essential to avoid complications due to the administration through a peripheral vein. Knowing the physicochemical characteristics of antimicrobials is crucial to improve the patient’s safety significantly, thus avoiding administration errors and local side effects.