Статті в журналах: "Antimicrobial biomaterials for wound healing"

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Antezana, Pablo Edmundo, Sofia Municoy, Claudio Javier Pérez, and Martin Federico Desimone. "Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil." Antibiotics 10, no. 11 (November 20, 2021): 1420. http://dx.doi.org/10.3390/antibiotics10111420.

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Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver nanoparticles and Cannabis sativa oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. Cannabis sativa oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing.

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Râpă, M., M. D. Berechet, C. Gaidău, R. R. Constantinescu, and A. Moșuțiu. "ANTIMICROBIAL PROPERTIES OF RABBIT COLLAGEN GLUE-CHITOSAN BIOMATERIAL LOADED WITH CYMBOPOGON FLEXUOSUS ESSENTIAL OIL." TEXTEH Proceedings 2021 (October 22, 2021): 385–90. http://dx.doi.org/10.35530/tt.2021.46.

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One approach to develop innovative antimicrobial wound dressing materials is to use natural polymers loaded with antimicrobial agents. The valorisation of animal proteins as biomaterials with antimicrobial properties is a new concern for development of wound healing. Plant esssential oils (EO) also indicate a potential approach for new wound dressing materials able to replace the synthetic antymicrobial agents. In this paper, plant-polymeric film was prepared by casting film-forming emulsion based on lemongrass (Cymbopogon flexuosus) essential oil/Tween 80 dispersed into rabbit collagen glue hydrolysate– chitosan biomaterial. The effect of biomaterial film composition on Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 10536 standard bacteria, and Candida albicans ATCC 10231 pathogenic fungus was studied according to European Pharmacopoeia 10/2020 as compared with biomaterial film without essential oil. The in vitro antibacterial tests against three bacterial strains showed that the rabbit collagen glue hydrolysate–chitosan biomaterial inhibited all the three microorganisms. The rabbit collagen hydrolysate glue-chitosan film loaded with lemongrass essential oil exhibits antimicrobial activity towards tested microorganisms but lower as compared with control. The explanation could be due to the short time of investigation, or maybe some active compounds constituents of EO, which favour the cellular proliferation. Preparation of rabbit collagen glue hydrolysate-chitosan biomaterial loaded with lemongrass essential oil is an environmentally friendly solution, which may contribute to the development of wound healing materials as an alternative to topical antimicrobial agents.

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Della Sala, Francesca, Gennaro Longobardo, Antonio Fabozzi, Mario di Gennaro, and Assunta Borzacchiello. "Hyaluronic Acid-Based Wound Dressing with Antimicrobial Properties for Wound Healing Application." Applied Sciences 12, no. 6 (March 17, 2022): 3091. http://dx.doi.org/10.3390/app12063091.

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Wound healing is a naturally occurring process that can be aided by a wound dressing properly designed to assure an efficient healing process. An infection caused by several microorganisms could interfere with this process, delaying or even impairing wound healing. Hyaluronic acid (HA), a main constituent of the extracellular matrix (ECM) of a vertebrate’s connective tissue, represents a promising biomaterial for wound dressing thanks to its intrinsic biocompatibility, hydrophilicity and bacteriostatic properties. In this review, different and recent types of HA-based wound dressings endowed with intrinsic antimicrobial properties or co-adjuvated by antimicrobial natural or synthetic agents are highlighted.

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Kim, Jwa-Young, and Hyun Seok. "Role of 4-Hexylresorcinol in the Field of Tissue Engineering." Applied Sciences 10, no. 10 (May 14, 2020): 3385. http://dx.doi.org/10.3390/app10103385.

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4-hexylresorcinol (4-HR), as a derivative of phenolic lipids, has biological and pharmacological properties that are beneficial when used with a biomaterial. It has antimicrobial and antiseptic activity and can thus prevent contamination and infection of biomaterials. 4-HR suppresses the nuclear factor kappa B (NF-κB) signaling pathway related to osteoclast differentiation. The suppression of NF-κB increases the bone formation marker and contributes to new bone formation. The tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine produced by macrophages and suppressed by 4-HR. Suppression of TNF-α decreases osteoclast activity and promotes wound healing. 4-HR increases the vascular endothelial growth factor and has an anti-thrombotic effect. When incorporated into silk vascular patches, it promotes endothelium wound healing. Recently, 4-HR has exhibited biological properties and has been successfully incorporated into various biomaterials. Consequently, it is a useful pharmacological chemical that can be used with biomaterials in the field of tissue engineering.

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Akhmetova, Alma, Georg-Marten Lanno, Karin Kogermann, Martin Malmsten, Thomas Rades, and Andrea Heinz. "Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing." Pharmaceutics 12, no. 5 (May 18, 2020): 458. http://dx.doi.org/10.3390/pharmaceutics12050458.

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The development of biomaterials for wound healing applications requires providing a number of properties, such as antimicrobial action, facilitation of cell proliferation, biocompatibility and biodegradability. The aim of the present study was to investigate morphological and mechanical properties of zein-based microfibers, ultimately aimed at creating an environment suitable for wound healing. This was achieved through co-axial electrospinning of core–shell microfibers, with zein protein in the core and polyethylene oxide (PEO) in the shell. Small amounts of PEO or stearic acid were additionally incorporated into the fiber core to modify the morphology and mechanical properties of zein fibers. The presence of PEO in the core was found to be essential for the formation of tubular fibers, whereas PEO in the shell enhanced the stability of the microfibers in water and ensured high elasticity of the microfiber mats. Tetracycline hydrochloride was present in an amorphous form within the fibers, and displayed a burst release as a result of pore-formation in the fibers. The developed systems exhibited antimicrobial activity against Staphylococcus aureus and Escherichia coli, and showed no cytotoxic effect on fibroblasts. Biocompatibility, antimicrobial activity and favorable morphological and mechanical properties make the developed zein-based microfibers a potential biomaterial for wound healing purposes.

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Rossi, Martina, and Pasquale Marrazzo. "The Potential of Honeybee Products for Biomaterial Applications." Biomimetics 6, no. 1 (January 15, 2021): 6. http://dx.doi.org/10.3390/biomimetics6010006.

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The development of biomaterials required continuous improvements in their properties for new tissue engineering applications. Implants based on biocompatible materials and biomaterial-based dressings are susceptible to infection threat; moreover, target tissues can suffer injuring inflammation. The inclusion of nature-derived bioactive compounds usually offers a suitable strategy to expand or increase the functional properties of biomaterial scaffolds and can even promote tissue healing. Honey is traditionally known for its healing property and is a mixture of phytochemicals that have a proven reputation as antimicrobial, anti-inflammatory, and antioxidant agents. This review discusses on the potential of honey and other honeybee products for biomaterial improvements. Our study illustrates the available and most recent literature reporting the use of these natural products combined with different polymeric scaffolds, to provide original insights in wound healing and other tissue regenerative approaches.

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Varela, Patrícia, Susanna Sartori, Richard Viebahn, Jochen Salber, and Gianluca Ciardelli. "Macrophage immunomodulation: An indispensable tool to evaluate the performance of wound dressing biomaterials." Journal of Applied Biomaterials & Functional Materials 17, no. 1 (January 2019): 228080001983035. http://dx.doi.org/10.1177/2280800019830355.

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A major burden of the healthcare system resides in providing proper medical treatment for all types of chronic wounds, which are usually treated with dressings to induce a faster regeneration. Hence, to reduce healing time and improve the patient’s quality of life, it is extremely important to select the most appropriate constituent material for a specific wound dressing. A wide range of wound dressings exist but their mechanisms of action are poorly explored, especially concerning the immunomodulatory effects that occur from the interactions between immune cells and the biomaterial. Tissue-resident and monocyte-derived recruited macrophages are key regulators of wound repair. These phagocytic immune cells exert specific functions during the different stages of wound healing. The recognition of the substantial role of macrophages in the outcome of the wound healing process requires specific understanding of the immunomodulatory effects of commercially available or newly developed wound dressings. For a precise intervention, it is necessary to obtain more knowledge on macrophage polarization in different phases of wound healing in the presence of the dressings. The main purpose of this review is to collect clinical cases in which macrophage immunomodulation was taken into consideration as an indicator of the performances of novel or mainstream wound dressing materials, including those provided with antimicrobial properties.

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Liang, Yongping, Baojun Chen, Meng Li, Jiahui He, Zhanhai Yin, and Baolin Guo. "Injectable Antimicrobial Conductive Hydrogels for Wound Disinfection and Infectious Wound Healing." Biomacromolecules 21, no. 5 (May 11, 2020): 1841–52. http://dx.doi.org/10.1021/acs.biomac.9b01732.

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9

Yudaev, Pavel, Yaroslav Mezhuev, and Evgeniy Chistyakov. "Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects." Gels 8, no. 6 (May 24, 2022): 329. http://dx.doi.org/10.3390/gels8060329.

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The dressings containing nanoparticles of metals and metal oxides are promising types of materials for wound repair. In such dressings, biocompatible and nontoxic hydrophilic polymers are used as a matrix. In the present review, we take a look at the anti-microbial effect of the nanoparticle-modified wound dressings against various microorganisms and evaluate their healing action. A detailed analysis of 31 sources published in 2021 and 2022 was performed. Furthermore, a trend for development of modern antibacterial wound-healing nanomaterials was shown as exemplified in publications starting from 2018. The review may be helpful for researchers working in the areas of biotechnology, medicine, epidemiology, material science and other fields aimed at the improvement of the quality of life.

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Zhang, Ziyan, Shicheng Zhou, Yanzhe Zhang, Dankai Wu, and Xiaoyu Yang. "The dual delivery of growth factors and antimicrobial peptide by PLGA/GO composite biofilms to promote skin-wound healing." New Journal of Chemistry 44, no. 4 (2020): 1463–76. http://dx.doi.org/10.1039/c9nj05389a.

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Al-Arjan, Wafa Shamsan, Muhammad Umar Aslam Khan, Hayfa Habes Almutairi, Shadia Mohammed Alharbi, and Saiful Izwan Abd Razak. "pH-Responsive PVA/BC-f-GO Dressing Materials for Burn and Chronic Wound Healing with Curcumin Release Kinetics." Polymers 14, no. 10 (May 11, 2022): 1949. http://dx.doi.org/10.3390/polym14101949.

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Polymeric materials have been essential biomaterials to develop hydrogels as wound dressings for sustained drug delivery and chronic wound healing. The microenvironment for wound healing is created by biocompatibility, bioactivity, and physicochemical behavior. Moreover, a bacterial infection often causes the healing process. The bacterial cellulose (BC) was functionalized using graphene oxide (GO) by hydrothermal method to have bacterial cellulose-functionalized-Graphene oxide (BC-f-GO). A simple blending method was used to crosslink BC-f-GO with polyvinyl alcohol (PVA) by tetraethyl orthosilicate (TEOS) as a crosslinker. The structural, morphological, wetting, and mechanical tests were conducted using Fourier-transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), water contact angle, and a Universal testing machine (UTM). The release of Silver-sulphadiazine and drug release kinetics were studied at various pH levels and using different mathematical models (zero-order, first-order, Higuchi, Hixson, Korsmeyer–Peppas, and Baker–Lonsdale). The antibacterial properties were conducted against Gram-positive and Gram-negative severe infection-causing pathogens. These composite hydrogels presented potential anticancer activities against the U87 cell line by an increased GO amount. The result findings show that these composite hydrogels have physical-mechanical and inherent antimicrobial properties and controlled drug release, making them an ideal approach for skin wound healing. As a result, these hydrogels were discovered to be an ideal biomaterial for skin wound healing.

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Anisiei, Alexandru, Irina Rosca, Andreea-Isabela Sandu, Adrian Bele, Xinjian Cheng, and Luminita Marin. "Imination of Microporous Chitosan Fibers—A Route to Biomaterials with “On Demand” Antimicrobial Activity and Biodegradation for Wound Dressings." Pharmaceutics 14, no. 1 (January 4, 2022): 117. http://dx.doi.org/10.3390/pharmaceutics14010117.

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Microporous chitosan nanofibers functionalized with different amounts of an antimicrobial agent via imine linkage were prepared by a three-step procedure including the electrospinning of a chitosan/PEO blend, PEO removal and acid condensation reaction in a heterogeneous system with 2-formylphenylboronic acid. The fibers’ characterization was undertaken keeping in mind their application to wound healing. Thus, by FTIR and 1H-NMR spectroscopy, it was confirmed the successful imination of the fibers and the conversion degree of the amine groups of chitosan into imine units. The fiber morphology in terms of fiber diameter, crystallinity, inter- and intra-fiber porosity and strength of intermolecular forces was investigated using scanning electron microscopy, polarized light microscopy, water vapor sorption and thermogravimetric analysis. The swelling ability was estimated in water and phosphate buffer by calculating the mass equilibrium swelling. The fiber biodegradation was explored in five media of different pH, corresponding to different stages of wound healing and the antimicrobial activity against the opportunistic pathogens inflicting wound infection was investigated according to standard tests. The biocompatibility and bioadhesivity were studied on normal human dermal fibroblast cells by direct contact procedure. The dynamic character of the imine linkage of the functionalized fibers was monitored by UV-vis spectroscopy. The results showed that the functionalization of the chitosan microporous nanofibers with antimicrobial agents via imine linkage is a great route towards bio-absorbable wound dressings with “on demand” antimicrobial properties and biodegradation rate matching the healing stages.

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Neamtu, Bogdan, Andreea Barbu, Mihai Octavian Negrea, Cristian Ștefan Berghea-Neamțu, Dragoș Popescu, Marius Zăhan, and Vioara Mireșan. "Carrageenan-Based Compounds as Wound Healing Materials." International Journal of Molecular Sciences 23, no. 16 (August 14, 2022): 9117. http://dx.doi.org/10.3390/ijms23169117.

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The following review is focused on carrageenan, a heteroglycan-based substance that is a very significant wound healing biomaterial. Every biomaterial has advantages and weaknesses of its own, but these drawbacks are typically outweighed by combining the material in various ways with other substances. Carrageenans’ key benefits include their water solubility, which enables them to keep the wound and periwound damp and absorb the wound exudate. They have low cytotoxicity, antimicrobial and antioxidant qualities, do not stick to the wound bed, and hence do not cause pain when removed from the wounded region. When combined with other materials, they can aid in hemostasis. This review emphasizes the advantages of using carrageenan for wound healing, including the use of several mixes that improve its properties.

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Pollini, Mauro, and Federica Paladini. "Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin." Materials 13, no. 15 (July 29, 2020): 3361. http://dx.doi.org/10.3390/ma13153361.

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Nature is an incredible source of inspiration for scientific research due to the multiple examples of sophisticated structures and architectures which have evolved for billions of years in different environments. Numerous biomaterials have evolved toward high level functions and performances, which can be exploited for designing novel biomedical devices. Naturally derived biopolymers, in particular, offer a wide range of chances to design appropriate substrates for tissue regeneration and wound healing applications. Wound management still represents a challenging field which requires continuous efforts in scientific research for definition of novel approaches to facilitate and promote wound healing and tissue regeneration, particularly where the conventional therapies fail. Moreover, big concerns associated to the risk of wound infections and antibiotic resistance have stimulated the scientific research toward the definition of products with simultaneous regenerative and antimicrobial properties. Among the bioinspired materials for wound healing, this review focuses attention on a protein derived from the silkworm cocoon, namely silk fibroin, which is characterized by incredible biological features and wound healing capability. As demonstrated by the increasing number of publications, today fibroin has received great attention for providing valuable options for fabrication of biomedical devices and products for tissue engineering. In combination with antimicrobial agents, particularly with silver nanoparticles, fibroin also allows the development of products with improved wound healing and antibacterial properties. This review aims at providing the reader with a comprehensive analysis of the most recent findings on silk fibroin, presenting studies and results demonstrating its effective role in wound healing and its great potential for wound healing applications.

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Dart, Alexander, Mrinal Bhave, and Peter Kingshott. "Antimicrobial Peptide‐Based Electrospun Fibers for Wound Healing Applications." Macromolecular Bioscience 19, no. 9 (July 24, 2019): 1800488. http://dx.doi.org/10.1002/mabi.201800488.

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Wang, Yi, Zhenhua Yang, Hua Zhu, Honggen Qiu, Shengjie Li, Kaifeng Yang, and Jun Xu. "Antibacterial self-fused supramolecular polymer hydrogel for infected wound healing." Materials Research Express 9, no. 3 (March 1, 2022): 035401. http://dx.doi.org/10.1088/2053-1591/ac5953.

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Abstract Wound treatment is a huge challenge for healthcare systems, especially when the wound suffered infection. Therefore, it is essential to develop materials with antibacterial properties for wound repair. Herein, we integrated antimicrobial peptides with self-healing hydrogel for infectious wound treatment. The synthetic hydrogel was made by polymerizing N-acryloyl glycinamide (NAGA) monomers and doped with antimicrobial peptide Polymyxin E. Additionally, because of the bisamide structure of the side chains of the NAGA monomers, the hydrogen bond was formed and caused the supramolecular structure. The resulted hydrogel showed excellent self-healing property, biocompatibility, and antimicrobial property, which allowed it to be used as hydrogel dressing. In vivo experiment demonstrated that the hydrogel had the significant capability in promoting infectious wound healing. Therefore, this type of antibacterial self-healing supramolecular hydrogel is expected to serve as infectious wound dressing for medical healthcare applications.

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Rani Raju, Nithya, Ekaterina Silina, Victor Stupin, Natalia Manturova, Saravana Babu Chidambaram, and Raghu Ram Achar. "Multifunctional and Smart Wound Dressings—A Review on Recent Research Advancements in Skin Regenerative Medicine." Pharmaceutics 14, no. 8 (July 28, 2022): 1574. http://dx.doi.org/10.3390/pharmaceutics14081574.

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The healing of wounds is a dynamic function that necessitates coordination among multiple cell types and an optimal extracellular milieu. Much of the research focused on finding new techniques to improve and manage dermal injuries, chronic injuries, burn injuries, and sepsis, which are frequent medical concerns. A new research strategy involves developing multifunctional dressings to aid innate healing and combat numerous issues that trouble incompletely healed injuries, such as extreme inflammation, ischemic damage, scarring, and wound infection. Natural origin-based compounds offer distinct characteristics, such as excellent biocompatibility, cost-effectiveness, and low toxicity. Researchers have developed biopolymer-based wound dressings with drugs, biomacromolecules, and cells that are cytocompatible, hemostatic, initiate skin rejuvenation and rapid healing, and possess anti-inflammatory and antimicrobial activity. The main goal would be to mimic characteristics of fetal tissue regeneration in the adult healing phase, including complete hair and glandular restoration without delay or scarring. Emerging treatments based on biomaterials, nanoparticles, and biomimetic proteases have the keys to improving wound care and will be a vital addition to the therapeutic toolkit for slow-healing wounds. This study focuses on recent discoveries of several dressings that have undergone extensive pre-clinical development or are now undergoing fundamental research.

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Amer, Somaya, Noha Attia, Samir Nouh, Mahmoud El-Kammar, Ahmed Korittum, and Howaida Abu-Ahmed. "Fabrication of sliver nanoparticles/polyvinyl alcohol/gelatin ternary nanofiber mats for wound healing application." Journal of Biomaterials Applications 35, no. 2 (May 22, 2020): 287–98. http://dx.doi.org/10.1177/0885328220927317.

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Purpose In this study, we aimed to determine the regenerative and antimicrobial impact of the electrospun nanofiber mats, with/without silver nanoparticles (AgNPs), on full-thickness skin wounds in rabbits. Methods Polyvinyl alcohol was combined with gelatin to provide biocompatible electrospun binary nanofiber mats. AgNPs were added to the polyvinyl alcohol/gelatin mixture to obtain ternary nanofiber-AgNPs mats. Binary and ternary nanofiber mats were characterized by scanning electron microscopy before being applied as wound dressings in vivo. Subsequently, wound healing was evaluated. Results Both nanofiber/nanofiber-AgNPs mats improved the microscopic quality of the healed skin, albeit without obvious acceleration of the healing rate. As well, both types of nanofiber mats were able to combat microbial invasion into the wound bed. Conclusions Both binary polyvinyl alcohol/gelatin and ternary polyvinyl alcohol/gelatin/AgNPs nanofiber mats developed in the present study depicted similar regenerative and antimicrobial potential when applied as full-thickness wound dressing. However, in comparison to the binary nanofiber mats, no obvious synergistic effect was observed after loading nanofibers with AgNPs.

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Konop, Marek, Joanna Czuwara, Ewa Kłodzińska, Anna K. Laskowska, Urszula Zielenkiewicz, Iwona Brzozowska, Seyed M. Nabavi, and Lidia Rudnicka. "Development of a novel keratin dressing which accelerates full-thickness skin wound healing in diabetic mice: In vitro and in vivo studies." Journal of Biomaterials Applications 33, no. 4 (September 18, 2018): 527–40. http://dx.doi.org/10.1177/0885328218801114.

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Impaired wound healing is a major medical problem in diabetes. The objective of this study was to determine the possible application of an insoluble fraction of fur-derived keratin biomaterial as a wound dressing in a full thickness surgical skin wound model in mice ( n = 20) with iatrogenically induced diabetes. The obtained keratin dressing was examined in vitro and in vivo. In vitro study showed the keratin dressing is tissue biocompatible and non-toxic for murine fibroblasts. Antimicrobial examination revealed the keratin dressing inhibited the growth of S. aureus and E. coli. In vivo studies showed the obtained dressing significantly ( p < 0.05) accelerated healing during the first week after surgery compared to control wounds. Keratin dressings were incorporated naturally into granulation and regenerating tissue without any visible signs of inflammatory response, which was confirmed by clinical and histopathological analysis. It is one of the first studies to show application of insoluble keratin proteins and its properties as a wound dressing. The obtained keratin dressing accelerated wound healing in mice with iatrogenically induced diabetes. Therefore, it can be considered as a safe and efficient wound dressing. Although future studies are needed to explain the molecular mechanism behind fur-derived keratin effect during the multilayer wound healing process, our findings may open the way for a new class of insoluble fur keratin dressings in chronic difficult to heal wounds treatment.

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Abdel-Samad, Mohammad RK, and Fatma A. Taher. "Wound healing and antibacterial activities of water-soluble chitosan nanoparticles and excretion/secretion as a natural combination from medicinal maggots, Lucilia cuprina." Journal of Bioactive and Compatible Polymers 36, no. 6 (October 19, 2021): 510–19. http://dx.doi.org/10.1177/08839115211053921.

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Wounds management takes a high interest in the medical field and the addition of antimicrobial agents in an assortment of wound dressings leads to delay the wound healing. This study aimed at preparing natural combination between excretion/secretion (ES) and water-soluble chitosan nanoparticles (from Lucilia cuprina maggots) and investigating its antibacterial and wound healing activities. ES of maggots was collected, and the water-soluble chitosan nanoparticles (WSCNPs) were prepared and characterized. Antibacterial activities of combinations were evaluated against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Proteus vulgaris. ES-WSC-2 combination that contains 50% ES and 1% WSCNPs showed highest antibacterial activity against all tested bacteria compared to the other combinations. In vitro, the ES-WSC-2 combination was used to study the wound healing activity by scratch assay. The synergism between ES and WSCNPs (in ES-WSC-2 combination) accelerated the wound healing rate which suggests the use of this combination as an effective natural antibacterial and wound healing agent.

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Yupanqui Mieles, Joel, Cian Vyas, Enes Aslan, Gavin Humphreys, Carl Diver, and Paulo Bartolo. "Honey: An Advanced Antimicrobial and Wound Healing Biomaterial for Tissue Engineering Applications." Pharmaceutics 14, no. 8 (August 10, 2022): 1663. http://dx.doi.org/10.3390/pharmaceutics14081663.

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Honey was used in traditional medicine to treat wounds until the advent of modern medicine. The rising global antibiotic resistance has forced the development of novel therapies as alternatives to combat infections. Consequently, honey is experiencing a resurgence in evaluation for antimicrobial and wound healing applications. A range of both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains and biofilms, are inhibited by honey. Furthermore, susceptibility to antibiotics can be restored when used synergistically with honey. Honey’s antimicrobial activity also includes antifungal and antiviral properties, and in most varieties of honey, its activity is attributed to the enzymatic generation of hydrogen peroxide, a reactive oxygen species. Non-peroxide factors include low water activity, acidity, phenolic content, defensin-1, and methylglyoxal (Leptospermum honeys). Honey has also been widely explored as a tissue-regenerative agent. It can contribute to all stages of wound healing, and thus has been used in direct application and in dressings. The difficulty of the sustained delivery of honey’s active ingredients to the wound site has driven the development of tissue engineering approaches (e.g., electrospinning and hydrogels). This review presents the most in-depth and up-to-date comprehensive overview of honey’s antimicrobial and wound healing properties, commercial and medical uses, and its growing experimental use in tissue-engineered scaffolds.

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Dai, Zhaobo, Yuanhao Zhang, Chao Chen, Fan Yu, Jia Tian, Haibo Cai, Xiaoze Jiang, Liangshun Zhang, and Weian Zhang. "An Antifouling and Antimicrobial Zwitterionic Nanocomposite Hydrogel Dressing for Enhanced Wound Healing." ACS Biomaterials Science & Engineering 7, no. 4 (March 26, 2021): 1621–30. http://dx.doi.org/10.1021/acsbiomaterials.1c00039.

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Afrin, Samia, Md Shahruzzaman, Papia Haque, Md Sazedul Islam, Shafiul Hossain, Taslim Ur Rashid, Tanvir Ahmed, Makoto Takafuji, and Mohammed Mizanur Rahman. "Advanced CNC/PEG/PDMAA Semi-IPN Hydrogel for Drug Delivery Management in Wound Healing." Gels 8, no. 6 (May 30, 2022): 340. http://dx.doi.org/10.3390/gels8060340.

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A Semi Interpenetrating Polymer Network (semi-IPN) hydrogel was prepared and loaded with an antibiotic drug, gentamicin, to investigate the wound healing activity of this system. The semi-IPN hydrogel was synthesized by combining natural polymer cellulose nanocrystal (CNC) and synthetic polymer polyethylene glycol (PEG) and poly (N,N′-dimethyl acrylamide) (PDMAA), which was initially added as a monomer dimethyl acrylamide (DMAA). CNC was prepared from locally obtained jute fibers, dispersed in a PEG-NaOH solvent system and then mixed with monomer DMAA, where polymerization was initiated by an initiator potassium persulphate (KPS) and cross-linked by N,N′-methylenebisacrylamide (NMBA). The size, morphology, biocompatibility, antimicrobial activity, thermal and swelling properties of the hydrogel were investigated by different characterization techniques. The biocompatibility of the hydrogel was confirmed by cytotoxicity analysis, which showed >95% survival of the BHK-21, Vero cell line. The drug loaded hydrogel showed antimicrobial property by forming 25 and 23 mm zone of inhibition against Staphylococcus aureus (gram-positive) and Escherichia coli (gram-negative) bacteria, respectively, in antimicrobial analysis. At pH 5.5, 76% of the drug was released from the hydrogel within 72 h, as observed in an in vitro drug release profile. In an in vivo test, the healing efficiency of the drug loaded hydrogel was examined on a mice model with dorsal wounds. Complete healing of the wound without any scar formation was achieved in 12 days, which revealed excellent wound healing properties of the prepared drug loaded semi-IPN hydrogel. These results showed the relevance of such a system in the rapid healing of acute wounds.

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Soubhagya, A. S., K. Balagangadharan, N. Selvamurugan, D. Sathya Seeli, and M. Prabaharan. "Preparation and characterization of chitosan/carboxymethyl pullulan/bioglass composite films for wound healing." Journal of Biomaterials Applications 36, no. 7 (October 24, 2021): 1151–63. http://dx.doi.org/10.1177/08853282211050161.

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Wound dressings play a vital role in the wound healing process. Although a variety of wound dressings have been developed so far, most of them still have many drawbacks such as rigidity, non-porosity, low mechanical strength, an affinity to stick onto the injury surface and less antimicrobial activity. To overcome these issues, a novel type of porous three-dimensional (3D) film was fabricated using chitosan/carboxymethyl pullulan polyelectrolyte complex (PEC) loaded with 45S5 bioglass (CCMPBG) by the freeze-drying method for wound healing application. The developed films were analysed by FTIR, XRD, EDS and SEM to confirm their chemical nature, microstructure and surface morphologies. The CCMPBG films exhibited rough surface morphology and well-interconnected micropores with an average size range of 101–74 μm. Compared to the control chitosan/carboxymethyl pullulan (CCMP) film, the CCMPBG films showed an enhanced mechanical strength and controlled rate of swelling and biodegradation behaviours due to the interaction of polymer matrix and 45S5 bioglass (BG). Furthermore, CCMPBG films presented the improved biocompatibility, antimicrobial activity and wound closure ability because of the synergistic effects of chitosan, carboxymethyl pullulan (CMP) and BG. The results demonstrated that CCMPBG films can be an effective dressing material for wound therapy.

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Rodrigues, Michael, and Thilagavati Govindharajan. "Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing." Journal of Applied Biomaterials & Functional Materials 19 (January 2021): 228080002110549. http://dx.doi.org/10.1177/22808000211054930.

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A hydrocellular functional material as a wound dressing is developed and it is found to be superior in its efficacy as compared to some of the comparator controls in diabetic wound healing studies. A study on wound contraction and Histopathological analysis is done in rats. The efficacy of the dressing is comparable to the established wound dressings like Carboxymethyl cellulose alginate dressings and autolytic enzyme based hydrogel. It is found to be superior to Polyhexamethylene biguanide dressing used as reference controls in this study. The reason for good wound healing performance of the dressing can be attributed to a combined property of effective exudates management and broad spectrum antimicrobial effect. The concept of functional hydro cellular material has shown good results due to the excellent balance of exudates pickup and drying it out. This ensures moist wound healing conditions on the wound. Because of its porous nature it allows good air flow and gaseous exchange in the structure. The cationic sites created on the surface of the dressing ensure a good antimicrobial action on the exudates in the dressing. It reduces the infection load on the wound. The nonleaching property of the dressing also helps in preventing the generation of more resistant and mutant strains of the microbes. The developed dressing can be used as a relatively durable long lasting dressing for wound management in diabetic wounds. The need of repetitive wound dressing changes can be brought down with this concept of dressing. It is not only cost effective in terms of its material cost but also is a cost effective solution when entire wound management cost is considered. Such novel wound dressing material can change the quality of life of diabetic wound patients especially in developing world, where access to functional advanced wound care dressings is limited.

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Jaldin-Crespo, Limberg, Nataly Silva, and Jessica Martínez. "Nanomaterials Based on Honey and Propolis for Wound Healing—A Mini-Review." Nanomaterials 12, no. 24 (December 10, 2022): 4409. http://dx.doi.org/10.3390/nano12244409.

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Анотація:

Wound healing is a public health concern worldwide, particularly in chronic wounds due to delayed healing and susceptibility to bacterial infection. Nanomaterials are widely used in wound healing treatments due to their unique properties associated with their size and very large surface-area-to-volume ratio compared to the same material in bulk. The properties of nanomaterials can be expanded and improved upon with the addition of honey and propolis, due to the presence of bioactive molecules such as polyphenols, flavonoids, peptides, and enzymes. These bionanomaterials can act at different stages of wound healing and through different mechanisms, including anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulation, cell proliferation, and angiogenic effects. Biomaterials, at the nanoscale, show new alternatives for wound therapy, allowing for targeted and continuous delivery of beekeeping products at the injection site, thus avoiding possible systemic adverse effects. Here, we summarize the most recent therapies for wound healing based on bionanomaterials assisted by honey and propolis, with a focus on in vitro and in vivo studies. We highlight the type, composition (honey, propolis, and polymeric scaffolds), biological, physicochemical/mechanical properties, potential applications and patents related of the last eight years. Furthermore, we discuss the challenges, advantages, disadvantages and stability of different bionanomaterials related to their clinical translation and insight into the investigation and development of new treatments for wound healing.

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Li, Shuqi, Yansheng Zhang, Xiaozhen Ma, Shihui Qiu, Jing Chen, Guangming Lu, Zhen Jia, et al. "Antimicrobial Lignin-Based Polyurethane/Ag Composite Foams for Improving Wound Healing." Biomacromolecules 23, no. 4 (February 1, 2022): 1622–32. http://dx.doi.org/10.1021/acs.biomac.1c01465.

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Yi, Yu, Ting Huang, Yunxia Xu, Jianfeng Mei, Yanlu Zhang, Xudong Wang, Jianshu Chen, and Guoqing Ying. "Preparation and properties of N-glycosylated chitosan/polyvinyl alcohol hydrogels for use in wound dressings." Journal of Applied Biomaterials & Functional Materials 20 (January 2022): 228080002211018. http://dx.doi.org/10.1177/22808000221101809.

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Chitosan and its derivatives show potent biocompatibility, biodegradability, antimicrobial activity, hemostatic effects, and wound healing properties. Their application in wound dressings has garnered substantial research interest. In this work, we prepared a drug-loaded hydrogel by mixing N-glycosylated chitosan with polyvinyl alcohol (PVA), followed by loading of ofloxacin. A 2:1 volume ratio of chitosan to PVA was found to be optimal based on swelling and water evaporation rates. The slow-drug-release performance of the blended hydrogel was best when the ofloxacin loading was 5.0%. The ofloxacin-loaded hydrogel shows excellent antimicrobial properties in vitro and wound healing ability in an in vivo rabbit full-thickness excision wound model. The chitosan/PVA blended hydrogel has great potential for use in wound dressings and sustained drug release.

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Firlar, Ilayda, Mine Altunbek, Colleen McCarthy, Murugan Ramalingam, and Gulden Camci-Unal. "Functional Hydrogels for Treatment of Chronic Wounds." Gels 8, no. 2 (February 17, 2022): 127. http://dx.doi.org/10.3390/gels8020127.

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Chronic wounds severely affect 1–2% of the population in developed countries. It has been reported that nearly 6.5 million people in the United States suffer from at least one chronic wound in their lifetime. The treatment of chronic wounds is critical for maintaining the physical and mental well-being of patients and improving their quality of life. There are a host of methods for the treatment of chronic wounds, including debridement, hyperbaric oxygen therapy, ultrasound, and electromagnetic therapies, negative pressure wound therapy, skin grafts, and hydrogel dressings. Among these, hydrogel dressings represent a promising and viable choice because their tunable functional properties, such as biodegradability, adhesivity, and antimicrobial, anti-inflammatory, and pre-angiogenic bioactivities, can accelerate the healing of chronic wounds. This review summarizes the types of chronic wounds, phases of the healing process, and key therapeutic approaches. Hydrogel-based dressings are reviewed for their multifunctional properties and their advantages for the treatment of chronic wounds. Examples of commercially available hydrogel dressings are also provided to demonstrate their effectiveness over other types of wound dressings for chronic wound healing.

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Do, Thien Bui-Thuan, Tien Ngoc-Thuy Nguyen, Minh Hieu Ho, Nghi Thi-Phuong Nguyen, Thai Minh Do, Dai Tan Vo, Ha Thi-Ngoc Hua, et al. "The Efficacy of Silver-Based Electrospun Antimicrobial Dressing in Accelerating the Regeneration of Partial Thickness Burn Wounds Using A Porcine Model." Polymers 13, no. 18 (September 15, 2021): 3116. http://dx.doi.org/10.3390/polym13183116.

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(1) Background: Wounds with damages to the subcutaneous are difficult to regenerate because of the tissue damages and complications such as bacterial infection. (2) Methods: In this study, we created burn wounds on pigs and investigated the efficacy of three biomaterials: polycaprolactone-gelatin-silver membrane (PCLGelAg) and two commercial burn dressings, Aquacel® Ag and UrgoTulTM silver sulfadiazine. In vitro long-term antibacterial property and in vivo wound healing performance were investigated. Agar diffusion assays were employed to evaluate bacterial inhibition at different time intervals. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time-kill assays were used to compare antibacterial strength among samples. Second-degree burn wounds in the pig model were designed to evaluate the efficiency of all dressings in supporting the wound healing process. (3) Results: The results showed that PCLGelAg membrane was the most effective in killing both Gram-positive and Gram-negative bacteria bacteria with the lowest MBC value. All three dressings (PCLGelAg, Aquacel, and UrgoTul) exhibited bactericidal effect during the first 24 h, supported wound healing as well as prevented infection and inflammation. (4) Conclusions: The results suggest that the PCLGelAg membrane is a practical solution for the treatment of severe burn injury and other infection-related skin complications.

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Li, Linhua, Yanan Wang, Kunpeng Liu, Li Yang, Bo Zhang, Qingfeng Luo, Rifang Luo, and Yunbing Wang. "Nanoparticles-stacked superhydrophilic coating supported synergistic antimicrobial ability for enhanced wound healing." Materials Science and Engineering: C 132 (January 2022): 112535. http://dx.doi.org/10.1016/j.msec.2021.112535.

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Barud, Hernane da Silva, Adalberto Miguel de Araújo Júnior, Sybele Saska, Letícia Boldrin Mestieri, Juliana Alvares Duarte Bonini Campos, Rubens Moreno de Freitas, Nathália Ursoli Ferreira, et al. "Antimicrobial Brazilian Propolis (EPP-AF) Containing Biocellulose Membranes as Promising Biomaterial for Skin Wound Healing." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/703024.

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Among remarkable discoveries concerning propolis, such as antifungal, antiviral, and antioxidant activities, its anti-inflammatory, and mainly its antibacterial, properties deserve special attention when skin wound healing is concerned. Based on this and knowing the distinctive performance of bacterial (BC) membranes on wound healing, in this work it is proposed to demonstrate the potent antimicrobial activity and wound healing properties of a novel propolis containing biocellulose membrane. The obtained propolis/BC membrane was able to adsorb propolis not only on the surface, but also in its interstices demonstrated by scanning electron microscopy, X-ray diffraction, Fourier transform infrared (FT-IR) spectroscopy, and thermogravidimetric assays. Additionally, the polyphenolic compounds determination and the prominent antibacterial activity in the membrane are demonstrated to be dose dependent, supporting the possibility of obtaining propolis/BC membranes at the desired concentrations, taking into consideration its application and its skin residence time. Finally, it could be suggested that propolis/BC membrane may favor tissue repair in less time and more effectively in contaminated wounds.

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Lungu, Ramona, Maria-Alexandra Paun, Dragos Peptanariu, Daniela Ailincai, Luminita Marin, Mihai-Virgil Nichita, Vladimir-Alexandru Paun, and Viorel-Puiu Paun. "Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings." Gels 8, no. 2 (February 10, 2022): 107. http://dx.doi.org/10.3390/gels8020107.

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Supramolecular hydrogels based on chitosan and monoaldehydes are biomaterials with high potential for a multitude of bioapplications. This is due to the proper choice of the monoaldehyde that can tune the hydrogel properties for specific practices. In this conceptual framework, the present paper deals with the investigation of a hydrogel as bioabsorbable wound dressing. To this aim, chitosan was cross-linked with 2-formylphenylboronic acid to yield a hydrogel with antimicrobial activity. FTIR, NMR, and POM procedures have characterized the hydrogel from a structural and supramolecular point of view. At the same time, its biocompatibility and antimicrobial properties were also determined in vitro. Furthermore, in order to assess the bioabsorbable character, its biodegradation was investigated in vitro in the presence of lysosome in media of different pH, mimicking the wound exudate at different stages of healing. The biodegradation was monitored by gravimetrical measurements, SEM microscopy and fractal analyses of the images. The fractal dimension values and the lacunarity of SEM pictures were accurately calculated. All these successful investigations led to the conclusion that the tested materials are at the expected high standards.

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Shi, Linying, Fang Lin, Mou Zhou, Yanhui Li, Wendan Li, Guiqiu Shan, Yubing Xu, Jingjing Xu, and Jing Yang. "Preparation of biocompatible wound dressings with dual release of antibiotic and platelet-rich plasma for enhancing infected wound healing." Journal of Biomaterials Applications 36, no. 2 (April 14, 2021): 219–36. http://dx.doi.org/10.1177/0885328221996013.

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The ever-growing threats of bacterial infection and chronic wound healing have provoked an urgent need for novel antibacterial wound dressings. In this study, we developed a wound dressing for the treatment of infected wounds, which can reduce the inflammatory period (through the use of gentamycin sulfate (GS)) and enhance the granulation stage (through the addition of platelet-rich plasma (PRP)). Herein, the sustained antimicrobial CMC/GMs@GS/PRP wound dressings were developed by using gelatin microspheres (GMs) loading GS and PRP, covalent bonding to carboxymethyl chitosan (CMC). The prepared dressings exhibited high water uptake capability, appropriate porosity, excellent mechanical properties, sustain release of PRP and GS. Meanwhile, the wound dressing showed good biocompatibility and excellent antibacterial ability against Gram-negative and Gram-positive bacteria. Moreover, in vivo experiments further demonstrated that the prepared dressings could accelerate the healing process of E. coli and S. aureus-infected full-thickness wounds i n vivo, reepithelialization, collagen deposition and angiogenesis. In addition, the treatment of CMC/GMs@GS/PRP wound dressing could reduce bacterial count, inhibit pro-inflammatory factors (TNF-α, IL-1β and IL-6), and enhance anti-inflammatory factors (TGF-β1). The findings of this study suggested that biocompatible wound dressings with dual release of GS and PRP have great potential in the treatment of chronic and infected wounds.

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Oliveira, Renata Nunes, Maurício Cordeiro Mancini, Fernando Cabral Salles de Oliveira, Thayse Marques Passos, Brid Quilty, Rossana Mara da Silva Moreira Thiré, and Garrett Brian McGuinness. "FTIR analysis and quantification of phenols and flavonoids of five commercially available plants extracts used in wound healing." Matéria (Rio de Janeiro) 21, no. 3 (September 2016): 767–79. http://dx.doi.org/10.1590/s1517-707620160003.0072.

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ABSTRACT Natural products are used in wound healing in order to prevent infection. Propolis is a well known antimicrobial with phenolic compounds and flavonoid content which vary according to the propolis origin. Besides propolis (from both Brazilian and UK sources), pomegranate, dragon's blood and sage are possible antimicrobials to be used in biomaterials. The goal of this work was to analyze the amount of phenols and flavonoid compounds in these natural products, their antioxidant activities and the bonds present by FTIR. The FTIR analysis revealed the presence of active compounds in all drug samples. The phenols quantification showed that Brazilian propolis was rich in phenols compared to the other drugs, followed by pomegranate and UK propolis. UK propolis was the most rich in flavonoids, which is expected on account of its origin. Pomegranate, UK propolis and Dragon's blood presented the highest antioxidant activity. All samples presented antioxidant activity > 82%.

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Mishra, R. K., K. Ramasamy, S. M. Lim, M. F. Ismail, and A. B. A. Majeed. "Antimicrobial and in vitro wound healing properties of novel clay based bionanocomposite films." Journal of Materials Science: Materials in Medicine 25, no. 8 (May 16, 2014): 1925–39. http://dx.doi.org/10.1007/s10856-014-5228-y.

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Li, Tao, Mingchao Sun, and Shaohua Wu. "State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications." Nanomaterials 12, no. 5 (February 25, 2022): 784. http://dx.doi.org/10.3390/nano12050784.

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Electrospun nanofiber materials have been considered as advanced dressing candidates in the perspective of wound healing and skin regeneration, originated from their high porosity and permeability to air and moisture, effective barrier performance of external pathogens, and fantastic extracellular matrix (ECM) fibril mimicking property. Gelatin is one of the most important natural biomaterials for the design and construction of electrospun nanofiber-based dressings, due to its excellent biocompatibility and biodegradability, and great exudate-absorbing capacity. Various crosslinking approaches including physical, chemical, and biological methods have been introduced to improve the mechanical stability of electrospun gelatin-based nanofiber mats. Some innovative electrospinning strategies, including blend electrospinning, emulsion electrospinning, and coaxial electrospinning, have been explored to improve the mechanical, physicochemical, and biological properties of gelatin-based nanofiber mats. Moreover, numerous bioactive components and therapeutic agents have been utilized to impart the electrospun gelatin-based nanofiber dressing materials with multiple functions, such as antimicrobial, anti-inflammation, antioxidation, hemostatic, and vascularization, as well as other healing-promoting capacities. Noticeably, electrospun gelatin-based nanofiber mats integrated with specific functions have been fabricated to treat some hard-healing wound types containing burn and diabetic wounds. This work provides a detailed review of electrospun gelatin-based nanofiber dressing materials without or with therapeutic agents for wound healing and skin regeneration applications.

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Han, Qianqian, Xuan Wang, Lin Qiu, Xinpei Zhou, Zexuan Hui, Xinye Ni, Yang Xuan, Xiaoling Lei, and Jianhao Wang. "Gelatinase Responsive Nanogel for Antibacterial Phototherapy and Wound Healing." Gels 8, no. 7 (June 23, 2022): 397. http://dx.doi.org/10.3390/gels8070397.

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The unique bactericidal mechanism of metal nanoparticles (MNPs) is considered to be an effective strategy to deal with antibiotic resistance, but the oxidative stress damage caused by excessive accumulation of MNPs to normal cells cannot be ignored. Achieving on-demand release of nano-drugs in specific infection environments is highly attractive. Herein, we constructed a “core-shell” nanogel (G@CuS) based on a copper sulfide (CuS) antimicrobial agent and gelatin for targeted drug release and bacterial clearance in a gelatinase infected microenvironment. G@CuS produced heat and reactive oxygen species (ROS) under the irradiation of a laser, which together with the released Cu2+ cause irreversible and efficient physical damage to the bacteria. Moreover, the encapsulation of gelatin not only limits the biotoxicity of CuS nanodots (NDs), but also effectively promotes the proliferation of mammalian cells. Under the synergy of multiple mechanisms, G@CuS eradicated the colonized bacteria in the wound of mice infected with Staphylococcus aureus (S. aureus) and accelerated wound healing. The proposed application strategy of nanogel is expected to provide a new idea for clinical transformation.

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Costa-Pinto, Ana Rita, Ana Luísa Lemos, Freni Kekhasharú Tavaria, and Manuela Pintado. "Chitosan and Hydroxyapatite Based Biomaterials to Circumvent Periprosthetic Joint Infections." Materials 14, no. 4 (February 8, 2021): 804. http://dx.doi.org/10.3390/ma14040804.

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Every year, worldwide, millions of people suffering from joint pain undergo joint replacement. For most patients, joint arthroplasty reduces pain and improve function, though a small fraction will experience implant failure. One of the main reasons includes prosthetic joint infection (PJI), involving the prosthesis and adjacent tissues. Few microorganisms (MO) are required to inoculate the implant, resulting in the formation of a biofilm on its surface. Standard treatment includes not only removal of the infected prosthesis but also the elimination of necrotic bone fragments, local and/or systemic administration of antibiotics, and revision arthroplasty with a new prosthesis, immediately after the infection is cleared. Therefore, an alternative to the conventional therapeutics would be the incorporation of natural antimicrobial compounds into the prosthesis. Chitosan (Ch) is a potential valuable biomaterial presenting properties such as biocompatibility, biodegradability, low immunogenicity, wound healing ability, antimicrobial activity, and anti-inflammatory potential. Regarding its antimicrobial activity, Gram-negative and Gram-positive bacteria, as well as fungi are highly susceptible to chitosan. Calcium phosphate (CaP)-based materials are commonly utilized in orthopedic and dentistry for their excellent biocompatibility and bioactivity, particularly in the establishment of cohesive bone bonding that yields effective and rapid osteointegration. At present, the majority of CaP-based materials are synthetic, which conducts to the depletion of the natural resources of phosphorous in the future due to the extensive use of phosphate. CaP in the form of hydroxyapatite (HAp) may be extracted from natural sources as fish bones or scales, which are by-products of the fish food industry. Thus, this review aims to enlighten the fundamental characteristics of Ch and HAp biomaterials which makes them attractive to PJI prevention and bone regeneration, summarizing relevant studies with these biomaterials to the field.

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Thapa, Raj Kumar, Dzung B. Diep, and Hanne Hjorth Tønnesen. "Topical antimicrobial peptide formulations for wound healing: Current developments and future prospects." Acta Biomaterialia 103 (February 2020): 52–67. http://dx.doi.org/10.1016/j.actbio.2019.12.025.

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Ceresa, Chiara, Letizia Fracchia, Alice Marchetti, Maurizio Rinaldi, and Michela Bosetti. "Injectable Scaffolds Enriched with Silver to Inhibit Bacterial Invasion in Tissue Regeneration." Materials 12, no. 12 (June 15, 2019): 1931. http://dx.doi.org/10.3390/ma12121931.

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Анотація:

During wound healing, bacterial infections may prolong skin regeneration and tissue repair, causing delayed or incomplete healing. The therapeutic strategies currently used include general therapeutic modes, growth factors, skin substitutes, matrices and/or cell therapy. Among recent technologies, wound dressing materials comprising silver nitrate or silver sulfadiazine as the antimicrobial agent are widespread, despite their known cytotoxicity. The aim of this work was to develop and evaluate the efficacy of gelatinous injectable biomaterials composed of collagen and alginates, enriched with silver against bacterial pathogens commonly involved in wound infections. To reduce cytotoxicity, silver was used as lactate and saccharinated salts. Results show that silver-enriched beads were effective against both Gram-positive and Gram-negative strains in a concentration-dependent manner. Silver addition was more active against Staphylococcus epidermidis than against Pseudomonas aeruginosa. The antibacterial activity was localized only in the area of contact with the beads at concentrations lower than 0.3 mM, whereas at higher concentrations a larger inhibition halo was observed. No cytotoxic effect on eukaryotic cells was seen both testing the materials’ extracts or the Ag-doped beads in contact tests. These results, although preliminary, suggest that these scaffolds are a promising approach for realizing injectable or spreadable functional biomaterials with antibacterial activity for applications in wound management.

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Luneva, Olga, Roman Olekhnovich, and Mayya Uspenskaya. "Bilayer Hydrogels for Wound Dressing and Tissue Engineering." Polymers 14, no. 15 (August 1, 2022): 3135. http://dx.doi.org/10.3390/polym14153135.

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Анотація:

A large number of different skin diseases such as hits, acute, and chronic wounds dictate the search for alternative and effective treatment options. The wound healing process requires a complex approach, the key step of which is the choice of a dressing with controlled properties. Hydrogel-based scaffolds can serve as a unique class of wound dressings. Presented on the commercial market, hydrogel wound dressings are not found among proposals for specific cases and have a number of disadvantages—toxicity, allergenicity, and mechanical instability. Bilayer dressings are attracting great attention, which can be combined with multifunctional properties, high criteria for an ideal wound dressing (antimicrobial properties, adhesion and hemostasis, anti-inflammatory and antioxidant effects), drug delivery, self-healing, stimulus manifestation, and conductivity, depending on the preparation and purpose. In addition, advances in stem cell biology and biomaterials have enabled the design of hydrogel materials for skin tissue engineering. To improve the heterogeneity of the cell environment, it is possible to use two-layer functional gradient hydrogels. This review summarizes the methods and application advantages of bilayer dressings in wound treatment and skin tissue regeneration. Bilayered hydrogels based on natural as well as synthetic polymers are presented. The results of the in vitro and in vivo experiments and drug release are also discussed.

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Andra, Swetha, Satheesh kumar Balu, Rajalakshmi Ramamoorthy, Murugesan Muthalagu, Devisri Sampath, Karthika Sivagnanam, and Gobalakrishnan Arumugam. "Synthesis, characterization, and antimicrobial properties of novel dual drug loaded electrospun mat for wound dressing applications." Journal of Bioactive and Compatible Polymers 36, no. 5 (September 2021): 431–43. http://dx.doi.org/10.1177/08839115211046413.

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Wound healing properties of some herbs have been known for decades. Recently, electrospun mats have been used as a wound dressing material due to the high surface area of fiber and ease of incorporation of drug into the fiber matrix. In this aspect, the incorporation of herbal extracts in electrospun matrix could provide synergistic effect for wound healing. In the present work, extracts from Cissus quadrangularis (CQ) and Galinsoga parviflora Cav (GP) were loaded into the PVA solution in different proportions. These solutions were used to produce nanofibrous mat in electrospinning and the characteristics of the mat were analyzed. The morphology of the fiber was analyzed using scanning electron microscope (SEM), the presence of functional groups was identified using Fourier transform infrared spectroscopy (FTIR). The result of drug release shows that the GP extract loaded PVA nanofibrous mat has sustained drug release of 28% after 8 h of incubation compared to CQ loaded PVA nanofibrous mat. This trend follows as the concentration of GP increases in the mixture. The antimicrobial efficiency of the prepared mat was evaluated against both Gram-negative bacteria E. coli and Gram-positive bacteria S. aureus. The prepared nanofibrous mat has shown excellent antibacterial activity, cell viability, hemocompatibility, and sufficient tensile properties which indicates that it could be a promising biomaterial for wound dressing application.

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Surowiecka, Agnieszka, Jerzy Strużyna, Aleksandra Winiarska, and Tomasz Korzeniowski. "Hydrogels in Burn Wound Management—A Review." Gels 8, no. 2 (February 15, 2022): 122. http://dx.doi.org/10.3390/gels8020122.

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Анотація:

Inert hydrogels are of a great importance in burn first aid. Hydrogel dressings may be an alternative to cooling burn wounds with streaming water, especially in cases of mass casualty events, lack of clean water, hypothermia, or large extent of burns. Hydrogels that contain mostly water evacuate the heat cumulating in the skin by evaporation. They not only cool the burn wound, but also reduce pain and protect the wound area from contamination and further injuries. Hydrogels are ideally used during the first hours after injury, but as they do not have antimicrobial properties per se, they might not prevent wound infection. The hydrogel matrix enables incorporating active substances into the dressing. The active forms may contain ammonium salts, nanocrystal silver, zinc, growth factor, cytokines, or cells, as well as natural agents, such as honey or herbs. Active dressings may have antimicrobial activity or stimulate wound healing. Numerous experiments on animal models proved their safety and efficiency. Hydrogels are a new dressing type that are still in development.

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Letha, Neethu, Josna Joseph, Gayathri Sundar, Arun Unnikrishna Pillai, Annie John, and Annie Abraham. "Incorporation of phytochemicals into electrospun scaffolds for wound-healing applications in vitro and in vivo." Journal of Bioactive and Compatible Polymers 35, no. 4-5 (July 2020): 451–66. http://dx.doi.org/10.1177/0883911520939989.

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Despite advances in wound treatment, wound-associated infections and delayed healing still remains an ‘unmet clinical need’. The present treatment modalities include topical application of ointments and perhaps it may better be substituted by phytochemical incorporated nanofibers which increases wound-healing efficiency and reduce risk of infections. Hence, the aim of this study was to synthesise Areca catechu–incorporated polycaprolactone scaffolds for wound-healing applications. In this study, the tender nut of Areca catechu plant was collected and extracted with ethanol using the maceration technique. The presence of various active phytochemical constituents of ethanolic fraction of Areca catechu like phenol, flavonoid, tannin and alkaloid were identified qualitatively and estimated quantitatively. Areca catechu incorporated 10%w/w polycaprolactone scaffolds were fabricated by electrospinning technique and characterised physico-chemically by Fourier-transform infrared spectroscopy and scanning electron microscope analysis. In vitro cytotoxicity analysis was evaluated with L929 fibroblasts and in vivo wound-healing studies using rat models for both polycaprolactone and Areca catechu–incorporated polycaprolactone scaffolds. Extract of Areca catechu exhibited antioxidant properties and antibacterial activity against Staphylococcus aureus and Psuedomonus aeru ginosa. Scanning electron microscope image revealed the nanofibrous structural morphology of Areca catechu–incorporated polycaprolactone and polycaprolactone with average diameter of 350 and 399 nm, respectively. The characteristic peak of Fourier-transform infrared spectroscopy depicted the presence of biomolecules and detection of functional groups confirming the incorporation of Areca catechu into the polycaprolactone scaffold. Furthermore, cells were cytocompatible with 85% viability over Areca catechu–incorporated polycaprolactone scaffolds, and wounds treated with Areca catechu–incorporated polycaprolactone healed faster with a significant difference in the wound area than polycaprolactone controls. The phytochemical-incorporated polycaprolactone scaffolds with antioxidant, antimicrobial, biocompatible and wound-healing properties is proposed to be an indigenous approach towards wound care management globally and seems to be better and cost-effective wound dressings.

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Chircov, Cristina, Iuliana Teodora Bejenaru, Adrian Ionuț Nicoară, Alexandra Cătălina Bîrcă, Ovidiu Cristian Oprea, and Bianca Tihăuan. "Chitosan-Dextran-Glycerol Hydrogels Loaded with Iron Oxide Nanoparticles for Wound Dressing Applications." Pharmaceutics 14, no. 12 (November 28, 2022): 2620. http://dx.doi.org/10.3390/pharmaceutics14122620.

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Анотація:

Natural polymers have shown tremendous potential towards the development of hydrogels with tissue regeneration properties. Among them, chitosan and dextran are polysaccharides widely applied in the wound dressing area owing to their mucoadhesiveness, biodegradability, hemostatic potential, and intrinsic antibacterial activity, while glycerol is a well-known biocompatible solvent extensively used in the manufacture of cosmetic, pharmaceutical, medical, and personal care products. In order to enhance the properties of natural polymer-based hydrogels, the focus has currently shifted towards the addition of nanomaterials with antibacterial and regenerative potential, i.e., iron oxide nanoparticles. Thus, the aim of the present study was to develop a series of chitosan-dextran-glycerol hydrogels loaded with iron oxide nanoparticles, either readily added or formed in situ. The physicochemical properties of the so obtained hydrogels demonstrated an improved dispersibility of the in situ formed magnetite nanoparticles, which further decreases the porosity and swelling ratio of the hydrogels but increases the antimicrobial properties. Additionally, the presence of glycerol enhances the cell viability but reduces the antimicrobial potential. In this context, the results proved promising biological and antimicrobial properties, thus confirming their potential as biomaterials for wound healing and regeneration.

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47

Anjum, Sadiya, Amlan Gupta, Deepika Sharma, Shanti Kumari, Plabita Sahariah, Jutishna Bora, Surya Bhan, and Bhuvanesh Gupta. "Antimicrobial nature and healing behavior of plasma functionalized polyester sutures." Journal of Bioactive and Compatible Polymers 32, no. 3 (October 24, 2016): 263–79. http://dx.doi.org/10.1177/0883911516668665.

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This study deals with the development of bioactive poly(ethylene terephthalate) surgical suture by adopting the immobilization route with bioactive nanogels and chlorhexidine. Carbon dioxide plasma was used for the generation of carboxyl functionality on poly(ethylene terephthalate) surface for the immobilization of the bioactive components. The nanosilver nanogel was prepared using polyethylene glycol which helps in the reduction of silver ions into nanosilver as well as the stabilization of nanoparticles. The particle size of the nanogels, as evaluated by high-resolution transmission electron microscopy, was observed to be in the range of 10–50 nm. Surface functionalization of poly(ethylene terephthalate) filament was observed by attenuated total reflectance measurements and mechanical studies were investigated by Instron. Elemental analysis and surface topography were carried out by energy dispersive X-ray and atomic force microscopy. The cumulative release of silver from the dressing was found to be 68% of the total loading after 72 h. Coated sutures have excellent antimicrobial activity against both Escherichia coli and Staphylococcus aureus. In vivo wound healing and histopathology studies were carried out over a period of 72 h for skin wounds created on Swiss albino mice. Fast healing was observed in nanogel-treated wounds without any inflammatory effects on the newly generated skin. These sutures offer improved healing along with excellent antimicrobial properties and appear to be promising material against surgical infection.

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48

von Thadden, Carlota, Esra Altun, Mehmet Aydogdu, Mohan Edirisinghe, and Jubair Ahmed. "Antimicrobial Fibrous Bandage-like Scaffolds Using Clove Bud Oil." Journal of Functional Biomaterials 13, no. 3 (August 30, 2022): 136. http://dx.doi.org/10.3390/jfb13030136.

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Wounds are characterised by an anatomical disruption of the skin; this leaves the body exposed to opportunistic pathogens which contribute to infections. Current wound healing bandages do little to protect against this and when they do, they can often utilise harmful additions. Historically, plant-based constituents have been extensively used for wound treatment and are proven beneficial in such environments. In this work, the essential oil of clove bud (Syzygium aromaticum) was incorporated in a polycaprolactone (PCL) solution, and 44.4% (v/v) oil-containing fibres were produced through pressurised gyration. The antimicrobial activity of these bandage-like fibres was analysed using in vitro disk diffusion and the physical fibre properties were also assessed. The work showed that advantageous fibre morphologies were achieved with diameters of 10.90 ± 4.99 μm. The clove bud oil fibres demonstrated good antimicrobial properties. They exhibited inhibition zone diameters of 30, 18, 11, and 20 mm against microbial colonies of C. albicans, E. coli, S. aureus, and S. pyogenes, respectively. These microbial species are commonly problematic in environments where the skin barrier is compromised. The outcomes of this study are thus very promising and suggest that clove bud oil is highly suitable to be applied as a natural sustainable alternative to modern medicine.

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Păunica-Panea, Georgeta, Anton Ficai, Minodora Maria Marin, Ștefania Marin, Mădălina Georgiana Albu, Vlad Denis Constantin, Cristina Dinu-Pîrvu, Zina Vuluga, Mihai Cosmin Corobea, and Mihaela Violeta Ghica. "New Collagen-Dextran-Zinc Oxide Composites for Wound Dressing." Journal of Nanomaterials 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/5805034.

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The goal of this paper was the design, development, and characterization of some new composites, based on collagen and dextran as natural polymers and zinc oxide as antimicrobial, to be used in wound healing. Collagen hydrogels with various concentrations of dextran and zinc oxide were investigated in terms of rheological analysis. The spongious composites, obtained by freeze-drying of hydrogels, were evaluated by morphology (SEM), water uptake, and biological (enzymatic biodegradation) analysis. All the results were strongly influenced by the nature and concentration of composite components. Based on the performances of the hydrogels, stationary rheometry, porous structure, morphology, and biological behavior, the antimicrobial spongious composite based on collagen and dextran with 50% ZnO were the most promising for future applications in wound dressing and a biomaterial with high potential in skin regeneration.

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50

Elangwe, Collins N., Svetlana N. Morozkina, Roman O. Olekhnovich, Victoria O. Polyakova, Alexander Krasichkov, Piotr K. Yablonskiy, and Mayya V. Uspenskaya. "Pullulan-Based Hydrogels in Wound Healing and Skin Tissue Engineering Applications: A Review." International Journal of Molecular Sciences 24, no. 5 (March 4, 2023): 4962. http://dx.doi.org/10.3390/ijms24054962.

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Wound healing is a complex process of overlapping phases with the primary aim of the creation of new tissues and restoring their anatomical functions. Wound dressings are fabricated to protect the wound and accelerate the healing process. Biomaterials used to design dressing of wounds could be natural or synthetic as well as the combination of both materials. Polysaccharide polymers have been used to fabricate wound dressings. The applications of biopolymers, such as chitin, gelatin, pullulan, and chitosan, have greatly expanded in the biomedical field due to their non-toxic, antibacterial, biocompatible, hemostatic, and nonimmunogenic properties. Most of these polymers have been used in the form of foams, films, sponges, and fibers in drug carrier devices, skin tissue scaffolds, and wound dressings. Currently, special focus has been directed towards the fabrication of wound dressings based on synthesized hydrogels using natural polymers. The high-water retention capacity of hydrogels makes them potent candidates for wound dressings as they provide a moist environment in the wound and remove excess wound fluid, thereby accelerating wound healing. The incorporation of pullulan with different, naturally occurring polymers, such as chitosan, in wound dressings is currently attracting much attention due to the antimicrobial, antioxidant and nonimmunogenic properties. Despite the valuable properties of pullulan, it also has some limitations, such as poor mechanical properties and high cost. However, these properties are improved by blending it with different polymers. Additionally, more investigations are required to obtain pullulan derivatives with suitable properties in high quality wound dressings and tissue engineering applications. This review summarizes the properties and wound dressing applications of naturally occurring pullulan, then examines it in combination with other biocompatible polymers, such chitosan and gelatin, and discusses the facile approaches for oxidative modification of pullulan.

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