Дисертації з теми "Antigen-antibody complexes"
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Mustafa, Awder. "Circulating immune complexes in atherosclerotic vascular disease /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-018-0/.
Повний текст джерелаHanke, Tomas. "Development of solid matrix-antibody-antigen (SMAA) complexes as multivalent subunit vaccines." Thesis, University of St Andrews, 1994. http://hdl.handle.net/10023/13989.
Повний текст джерелаGreen, Elizabeth Allison. "The development and use of antigen-antibody-LTB (Ag-MAb-LTB) complexes as immunogens." Thesis, University of St Andrews, 1995. http://hdl.handle.net/10023/13984.
Повний текст джерелаBarbar, Elisar Jamil. "Nuclear Magnetic Resonance Study of Antigen-Antibody Complexes, Including Sequence Specific Assignments and Structural Analysis of Neurophysin as an Antigen Model." PDXScholar, 1993. https://pdxscholar.library.pdx.edu/open_access_etds/1167.
Повний текст джерелаNatale, Sara. "Utilising antigen-antibody complexes for the immunomagnetic enrichment of spermatozoa from sexual assault intimate swabs." Thesis, Natale, Sara (2021) Utilising antigen-antibody complexes for the immunomagnetic enrichment of spermatozoa from sexual assault intimate swabs. Masters by Research thesis, Murdoch University, 2021. https://researchrepository.murdoch.edu.au/id/eprint/64502/.
Повний текст джерелаHutchinson, Sean. "Utilising antigen-antibody complexes to capture and enrich for sperm cells fractions in a mixed substrate." Thesis, Hutchinson, Sean (2017) Utilising antigen-antibody complexes to capture and enrich for sperm cells fractions in a mixed substrate. Masters by Coursework thesis, Murdoch University, 2017. https://researchrepository.murdoch.edu.au/id/eprint/38406/.
Повний текст джерелаSchiele, Felix [Verfasser], Michael [Akademischer Betreuer] Groll, and Thomas [Akademischer Betreuer] Kiefhaber. "Structural And Biophysical Characterization of Antibody-Antigen Complexes of Therapeutic Relevance / Felix Schiele. Gutachter: Michael Groll ; Thomas Kiefhaber. Betreuer: Michael Groll." München : Universitätsbibliothek der TU München, 2013. http://d-nb.info/1034952064/34.
Повний текст джерелаSprenger, Kenneth John. "Circulating immune complexes in acute rheumatic carditis." Doctoral thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/27055.
Повний текст джерелаCarvalho, Camila Aparecida de. "Estudo da presença e influência de antígenos parasitários na sorologia da Leishmaniose visceral." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/99/99131/tde-21022014-112702/.
Повний текст джерелаVisceral leishmaniasis, caused by Leishmania (Leishmania) chagasi, is a chronic parasitic disease of humans and dogs. Confirmation of the protozoal agent in bone marrow, lymph node or spleen aspirate is diagnostic, while specific-IgG serology is used mainly for epidemiology despite the general presence of high levels of serum immunoglobulins. Anecdotal reports of false-negative serology in active disease cases are known and are ascribed to the formation of immune complexes. Because dissociation of immune complexes can be accomplished by acid treatment, we devised a simple, routine enzyme immunoassay (ELISA) for the dissociation of immune complexes in serum samples using acid treatment and neutralization in wells adsorbed with Leishmania antigen (dELISA). Confirmatory acid DOT-ELISA was also developed for antigen detection by anti-Leishmania rabbit antiserum. In experimental L. (L.) chagasi hamster models, immune complexes interfered with ELISA mostly in the early stages of infection, according to both dELISA and antigen DOT-ELISA results. In larger samples from endemic areas, dELISA increased seropositivity by 10% in negative dog samples (7/70) and 3.5% in negative human samples (3/85), showing that dELISA could be used in the serodiagnosis of visceral leishmaniasis. Moreover, dELISA could be used as an alternative approach to screening asymptomatic visceral leishmaniasis patients, instead of invasive confirmatory testing.
Mahmoud, Tamer I. "The significance of heavy chain CDR3 diversity in the antibody response to polysaccharides." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/mahmoud.pdf.
Повний текст джерелаHolm, Patrik. "Functional mapping and in vivo metabolism of the monoclonal antibody TS1 and its single-chain fragment : Its interaction with the antigen and the anti-idiotype." Doctoral thesis, Karlstad University, Faculty of Technology and Science, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-727.
Повний текст джерелаAntibodies are proteins capable of specific interactions to a wide range of molecules. These interactions are facilitated by the complementary determining regions (CDR).
Carcinomas are the most common of human cancers and they release significant amount of cytokeratins (CK) in the necrotic areas of the tumors. The CKs stay in the tumor, since they have low solubility. The antibody studied in this thesis, the anti-CK 8 antibody TS1, has shown to be effective in tumor targeting and is proposed to be useful in therapy.
Single-chain antibodies (scFv) are recombinant antibodies which are much smaller than the intact IgG. This is an advantage when used in tumor therapy, since they can penetrate the tumors more easily than the larger IgG. Moreover, they are expressed by one single gene which make them easy to modify, for example by site-directed mutagenesis.
The anti-idiotypic antibody αTS1 can be used to clear the TS1 form the circulation and thereby clear the body from non-tumor bound TS1 in therapy. To be able to modify the binding of an antibody to its antigen and or anti-idiotype, these interactions must be studied. In this study this is accomplished by chemical modifications of the IgGs TS1 and αTS1 and the antigen CK 8. Guided by these results, amino acid residues were mutated by using site-directed mutagenesis in the TS1-218 scFv and the effects were studied. From mutational study results, the functional epitope could be mapped and it was found that there are mainly tyrosines, but also charged residues, serine and a tryptophan that are important for both interactions. The binding of TS1-218 to both αTS1 and CK 8 could be improved by changing the negatively charged side-chains by mutations to their corresponding amide or alanine.
Both the IgG and scFv versions of TS1 were administered in vivo. The IgG αTS1 was used to clear the TS1 from the circulation by forming immune complexes. The immune complexes, consisting of four or more antibodies, were mainly metabolized by the liver. The scFv TS1-218 could localize to the tumor in a tumor xenograft mouse model, although a higher uptake would be desired in a therapeutic strategy. The scFv was cleared rapidly by the kidneys, but the clearance could be slowed by pre-formed immune complexes with anti-TS1 scFv in vitro, prior to administration in vivo.
Mathsson, Linda. "Immune Complex Regulated Cytokine Production in Rheumatic and Lymphoproliferative Diseases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7446.
Повний текст джерелаSantoro, Lyse. "Appretement et présentation d'un anticorps monoclonal murin par une lignée monocytaire ou lymphocytaire B humaine : influence de la liaison covalente entre anticorps et fragment C3b du complément." Grenoble 1, 1994. http://www.theses.fr/1994GRE10126.
Повний текст джерелаLin, Yu-Wen, and 林玉雯. "Photoinduce Antibody-Antigen Complexes to Dissociate." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/68329454260731283348.
Повний текст джерела國立清華大學
工程與系統科學系
94
This research proposes a photochemical method to dissociate immune complexes, decrease the hurt to protein of traditional acid washing by extremely shot operation time. We used the well-known characteristic of o-NBA molecules that can be photoinduced proton releasing by 365nm irradiation and make pH jump in the solution to dissociate immune complexes. In order to prove our proposal, we set up a flowing system, fixed antibody which has fluorescence and antigen modified with quencher which can quench the fluorescence in it. Because the effective distant of quencher quenches fluorescence is very shot (~10nm), only when antigens binds to antibodies, the distant is shot enough to quench the fluorescence. We judgment if antibody and antigen bind or not by fluorescence was quenched or not. The fluorescent dye we chose was quantum dots because of its fluorescence won’t be influenced by the pH value changes in the environment. Base on our results of experiments this method is workable, and it got similar recovery ratio to the solution pH=3.
Jhuang, Shu-Ting, and 莊淑婷. "Surface Confined Photo-induced Proton for Antibody-antigen Complexes Dissociation." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/93375424365457260072.
Повний текст джерелаVenkatesh, N. "Monoclonal Antibodies As Probes To Protein Structure And Function : Studies On Human Chorionic Gonadotropin." Thesis, 1997. http://etd.iisc.ernet.in/handle/2005/1786.
Повний текст джерелаPerdue, Samuel Scott. "Structural, functional and energetic analysis of antibodies in complex with staphylococcal nuclease /." 1997. http://wwwlib.umi.com/dissertations/fullcit/9724678.
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