Дисертації з теми "Antidepressants Mechanisms of action"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 дисертацій для дослідження на тему "Antidepressants Mechanisms of action".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Mann, Catherine. "Mechanisms of action of antidepressant drugs: Presynaptic and postreceptor mechanisms." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/10600.
Повний текст джерелаTabaka, John. "Mechanisms of action of antidepressants and their combination for major depressive disorder treatment: a theoretical and clinical approach." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121186.
Повний текст джерелаContexte: Chaque année, on estime que 8.2% des Canadiens âgés de 18 ans ou plus sont touchés par un trouble dépressif majeur (TDM). Près de la moitié des personnes souffrant de TDM ne parviendra pas à atteindre la rémission tout en ayant une réponse inadéquate au premier traitement antidépresseur pris seul durant 6 semaines continues. Ce défaut de rémission ou de répondre à la monothérapie, appelée dépression résistante au traitement (DRT), affecte plus de 30% des personnes souffrant de TDM. L'ajout d'un second antidépresseur pour améliorer les effets du médicament ou atténuer les effets secondaires de l'antidépresseur a montré à maintes reprises d'encourageants avantages thérapeutiques. Malheureusement, l'utilisation de la thérapie de combinaison dans les milieux cliniques reste relativement faible. Objectif: L'objectif principal de ce travail de recherche était de revisiter la littérature scientifique, à partir des études précliniques menées sur les antidépresseurs chez l'unité de Psychiatrie Neurobiologique à l'université McGill et des études cliniques à partir de PubMed/OvidSP, afin de comprendre le mécanisme d'action des antidépresseurs et les combinaisons possibles les plus efficaces. Ces données de la littérature ont été ensuite comparées avec une banque de données cliniques du programme de troubles de l'humeur du centre universitaire de santé McGill (CUSM), qui est un centre de soins tertiaires psychiatriques, avec le but d'établir la pertinence clinique de l'utilisation des combinaisons d'antidépresseurs. Méthodes: Une revue des études publiés dans la littérature a été effectuée pour discerner les antidépresseurs les plus prescrits et les combinaisons d'antidépresseurs les plus efficaces. Par la suite, nous avons analysé la banque de données du CUSM; 133 patients en consultation externe ayant un diagnostic du DSM-IV de TDM âgés de 18 ans ou plus ont été inclus dans cette étude. Les renseignements sociodémographiques et cliniques de chaque patient ont été obtenus au cours de sa première évaluation diagnostique par une équipe pluridisciplinaire et examen des dossiers. Les patients ont également été invités à remplir un questionnaire d'auto-évaluation de BDI-II afin d'évaluer la sévérité des symptômes dépressifs. Des analyses statistiques entre les combinaisons d'antidépresseurs prescrits et la sévérité des symptômes ont été effectuées. Une comparaison critique de ces résultats de la littérature avec les données cliniques de la banque du CUSM a été réalisée. Résultats: Beaucoup plus de femmes que d'hommes ont été diagnostiqués avec TDM. Dans les six mois suivant leur diagnostic initial, 87.2% des patients avaient été prescrit un antidépresseur. L'antidépresseur le plus prescrit est un ISRS, suivi par un IRSNa et le bupropion. Conformément à la documentation, les traitements combinés d'antidépresseurs les plus fréquents étaient i) ISRS + bupropion, ii) IRSNa + bupropion, et iii) IRSNa + mirtazapine. Aucune différence significative n'a été observée entre les traitements de combinaisons d'antidépresseurs et la moyenne totale des résultats du BDI-II. Conclusions: Les résultats cliniques étaient généralement conformes aux études passées. Les études sont favorables à l'utilisation de combinaisons d'antidépresseurs pour le traitement efficace et plus rapide de TDM, en particulier au début du traitement, mais les psychiatres semblaient encore hésitants sur l'utilisation de cette approche. Les combinaisons de bupropion avec un ISRS ou IRSNa se sont révélées être les combinaisons les plus efficaces, bénéficiant d'un soutien fréquent dans les études passées et dans cette étude. Limitations:Le faible taux d'achèvement du questionnaire BDI-II ont abouti à des pouvoirs de tests effectués à être plus faible que les pouvoirs voulus, réduisant ainsi la probabilité de détecter une différence qui peut avoir réellement existé. Une cohorte plus importante de patients pourrait permettre d'observer des différences cliniquement significatives.
Mustafa, M. R. "Involvement of noradrenergic mechanisms in the antidepressant action of rolipram." Thesis, Cardiff University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378451.
Повний текст джерелаCoull, Moyra Ann. "Signal transduction mechanisms in affective disorders and antidepressant drug action." Thesis, St George's, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393163.
Повний текст джерелаPetermann, Markus. "Identifying the mechanisms of antidepressant drug action in mice lacking brain serotonin." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/23035.
Повний текст джерелаSerotonin, the "molecule of happiness" is an important target for antidepressants. The mainly prescribed drugs in major depression are selective serotonin re-uptake inhibitors (SSRI); but recently, SSR-enhancer (SSRE) have also attracted clinical attention. However, only a quarter of patients responds to treatment. It needs to be determined, whether SSRI/E act solely via manipulating serotonin levels or whether other pathways are involved, e.g. neurotrophic signaling (brain-derived neurotrophic factor, BDNF) or the hypothalamus-pituitary-adrenal (HPA)-axis. Furthermore, in major depression, dysregulation of central serotonin signaling is accompanied with a decline in hippocampal neurogenesis, as has been observed in rodent models. At the center of this thesis is a mouse model deficient in the central serotonin-synthesizing enzyme, tryptophan hydroxylase 2 (Tph2-/- mice). I have investigated physiological responses to antidepressant treatment in the absence of brain serotonin, and the possible role of alternative pathways. I observed the typical increase in neurogenesis upon SSRI treatment in WT mice, while it had no effect in Tph2-/- mice. In contrast, BDNF levels were significantly decreased in Tph2-/- mice after treatment with no effect in WT control mice. Furthermore, my results show a critical role of brain serotonin in the neurobiological effects of electroconvulsive seizure. Surprisingly, in animals lacking central serotonin, increased neurogenesis was observed independently of the treatment. The gathered data indicated an altered stress response; therefore, parameters of the HPA-axis have been studied, indicating a downregulated HPA system in Tph2-/-animals in baseline state, but showed no difference in treatment or feedback control. This thesis gives insight into the mechanisms of antidepressant action and reveals ideas for novel pathways involved in the process that could be used as targets in therapeutic approaches and further research in major depression.
Petermann, Markus [Verfasser]. "Identifying the mechanisms of antidepressant drug action in mice lacking brain serotonin / Markus Petermann." Berlin : Humboldt-Universität zu Berlin, 2021. http://d-nb.info/1237268524/34.
Повний текст джерелаPariante, Carmine Maria. "The in vitro effects of antidepressants on the glucocorticoid receptor and the potential relevance for the mechanism of action of this class of drugs." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406497.
Повний текст джерелаAbdel-Razaq, Wesam. "Molecular mechanisms of monoamine neurotransmitter modulatory antidepressant actions." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435767.
Повний текст джерелаNeves, António Luís Alexandre. "Tratamento farmacológico da depressão." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5309.
Повний текст джерелаAs organizações mundias de saúde consideram a depressão uma desordem de humor apresentando muitas facetas e uma variedade de possíveis etiologias que provoca forte impacto na qualidade de vida do doente e dos seus familiares. A depressão é um problema de saúde pública, tendo em vista o aumento no número de casos e as suas consequências sociais. Uma elevada percentagem dos doentes com depressão desenvolvem a tendências para o suicídio e podem evoluir para tentativa do mesmo. A doença ocorre em todas as faixas etárias, desde os jovens até aos idosos. A prevalência média da depressão na população geral é mais comum nas mulheres com idade compreendida entre os 15 e os 29 anos e menos prevalente nos indivíduos com 50 ou mais anos. A depressão é um problema médico, passível de tratamento e, nas últimas cinco décadas, a psicofarmacologia da depressão evoluiu muito e rapidamente aumentando o número de fármacos disponíveis no mercado. Assim, atualmente o mercado dispõe de diversos antidepressivos com eficácia para o tratamento da depressão. Apesar das diferenças estruturais e do mecanismo de ação, os antidepressivos apresentam, de um modo geral, a mesma eficácia entre as diferentes classes. No entanto, a farmacocinética das substâncias podem alterar a biodisponibilidade e os efeitos adversos das mesmas, tornando-se um fator preponderante para a não adesão à terapia. A escolha do antidepressivo deverá ser baseada em vários fatores tais como: o tipo de sintomatologia, a idade, o uso concomitantes com outras terapias e a história clínica do doente. Este trabalho procura fazer uma revisão bibliográfica no âmbito do tratamento farmacológico da depressão, bem como do mecanismo de ação, da farmacocinética, dos efeitos laterais e das interações farmacológicas das diferentes classes de antidepressivos.
The mundial health organizations consider depression a mood disorder presenting many facets and a variety of possible etiologies that causes strong impact on quality of life of patients and their families. Depression is a public health problem, given the increase in the number of cases and its social consequences. A high percentage of patients with depression develop tendencies towards suicide and may progress to attempt the same. The disease occurs in all age groups, from the young to the elderly. The average prevalence of depression in the general population is more common among women aged 15 to 29 years and less prevalent in individuals with 50 or more years. The depression is a medical condition, treatable and in the last five decades the psychopharmacology of depression has evolved very quickly and increasing the number of drugs available in the market. Currently, the market offers many antidepressants effectively for the treatment of depression. Despite the structural differences and their mechanism of action, the antidepressants generally have the same efficacy between different classes. However, the pharmacokinetics of substances can alter the bioavailability and adverse effects of the same, becoming an important factor for non-adherence to therapy. The choice of the antidepressant should be based on various factors such as the type of symptoms, age, concomitant use with other therapies, and patient history. This paper seeks to make a literature review about the pharmacology of antidepressants particularly the pharmacological treatment of depression and the mechanism of action, pharmacokinetics, side effects and drug interactions thereof.
Schroeder, Frederick Albert. "A Role for Histone Modification in the Mechanism of Action of Antidepressant and Stimulant Drugs: a Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/370.
Повний текст джерелаHaddjeri, Nasser. "Auto- and heteromodulation of the rat brain 5-HT system : involvement in the mechanism of action of antidepressant drugs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ36978.pdf.
Повний текст джерелаPhillips, Marc Antony. "An investigation of monoaminergic mechanisms in the regulation of pupil size and the acoustic startle reflex in man." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324546.
Повний текст джерелаYon, Daniel. "Sensory prediction mechanisms in action." Thesis, Birkbeck (University of London), 2018. http://bbktheses.da.ulcc.ac.uk/362/.
Повний текст джерелаTyrrell, Toby. "Computational mechanisms for action selection." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/20257.
Повний текст джерелаPrabhu, G. "Neural mechanisms of object-oriented action." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1445241/.
Повний текст джерелаRicher, Maxime. "Characterization of the serotonergic and noradrenergic systems in mice lacking the 5-HTA receptor and its relevance to the mechanism of action of antidepressant drugs." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33831.
Повний текст джерелаPharmacological and electrophysiological studies have shown the essential role of the somatodendritic 5-HT1A autoreceptor in the control of dorsal raphe 5-HT neuronal firing frequency and release; these characteristics make this receptor an extremely interesting target for adjuvant drugs that potentiate or even accelerate the effect of actual antidepressants molecules. In fact, augmentation of synaptic levels of 5-HT, thought to be necessary for the beneficial action of antidepressants in mood, does not immediately occur subsequent to acute administration of those molecules but depends on the desensitization of 5-HT1A somatodendritic autoreceptors located in the dorsal raphe, a phenomenom temporally correlated with the onset of action of all antidepressant classes.
Ainsworth, Kerri. "Neuropharmacological studies of antidepressant action on brain dopamine systems." Thesis, University of Oxford, 1998. http://ora.ox.ac.uk/objects/uuid:15c300a8-1395-4a8c-be8e-474c42c5a5b5.
Повний текст джерелаBarkhem, Tomas. "Molecular mechanisms of estrogen and antiestrogen action /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-359-7/.
Повний текст джерелаFox, Stephanie. "Measles and Vitamin A : mechanisms of action." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32992.
Повний текст джерелаCraven, Robert Anthony. "Execution mechanisms for the action language C+." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445886.
Повний текст джерелаChivers, Joanna Elizabeth. "Mechanisms of glucocortical action in epithelial cells." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415076.
Повний текст джерелаHarrison, Julian Earle. "Mechanisms of action of transdermal penetration enhancement." Thesis, Cardiff University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321746.
Повний текст джерелаHassan, Lobna Mohammed Saber Abdel. "Intracellular mechanisms of action of cardioprotective agents." Thesis, University of Sunderland, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338350.
Повний текст джерелаKwok, Rebecca Martha. "Visual mechanisms subserving perceptual judgement and action." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408703.
Повний текст джерелаDi, Daniel Elena. "Mechanisms of action of mood-stabilizing drugs." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445413/.
Повний текст джерелаDuan, Xuchen. "Physiological and biological mechanisms of bisphosphonate action." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:36b0439d-2f89-4c1e-8bb3-941b4e6ee847.
Повний текст джерелаQuested, Digby John. "Serotonin receptor mechanisms in anti-depressant action." Master's thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/12577.
Повний текст джерелаSerotonin neurones have been implicated in the pathophysiology and treatment of clinical depression to a greater degree than any other neurotransmitter. Additionally, serotonin pathways may playa role in the pathophysiology and treatment of eating disorders, anxiety states and schizophrenia. Molecular biological studies have confirmed pharmacological evidence suggesting the existence of multiple serotonin receptor subtypes and the genes for these receptors, as well as that of the serotonin transporter, have common polymorphic variants. To investigate the effect of repeated treatment with selective serotonin fe-uptake inhibitors (SSRI's) on the function of central 5-HT2C receptors. To assess the effect of polymorphic variation in the 5-HT2c receptor and serotonin transporter on functional responses to selective pharmacological challenge. To determine whether polymorphic variation in the 5-HT receptor and serotonin transporter influence the clinical response of patients with major depression to treatment with serotonergic antidepressants. To assess the effect of repeated treatment with selective serotonin re-uptake inhibitors (SSRI's) on the function of central 5-HT2c receptors I used the 5-HT2C receptor agonist, m-chlorophenylpiperazine (m-CPP) as a 5-HT2c probe in a neuroendocrine challenge paradigm. I used the same approach to assess whether polymorphic variation in the 5-HT2c receptor (serine vs cysteine substitution) was associated with differences in functional response to 5-HT2C receptor challenge. I then studied whether polymorphic variation in the serotonin transporter promotor region (long versus short form) was associated with differing functional responses to acute challenge with clomipramine, a tricyclic antidepressant with a high affinity for the serotonin transporter. Finally, I studied whether either of these polymorphic variants influenced the clinical response of patients with major depression to treatment with SSRI's and clomipramine. SSRI treatment significantly lowered the sensitivity of 5-HT2c receptors as predicted from animal experimental studies. However polymorphic variation in the 5-HTzc receptor did not significantly influence functional responses to m-CPP challenge. In contrast polymorphic variation in the serotonin transporter was associated with differing neuroendocrine responses to acute clomipramine challenge with greater prolactin release being seen in subjects with the long polymorphic variant. Neither the 5-HTzc nor the transporter polymorphisms correlated with clinical response to SSRI and clomipramine treatment in patients with major depression. The ability of SSRI's to produce a functional down-regulation of 5-HTzc receptors may be relevant to certain of their therapeutic effects. Polymorphic variation in the 5-HT2c receptor (serine vs cysteine) seems unlikely to explain functional differences in responses to 5-HTzc receptor challenge or antidepressant responses to SSRI treatment. In contrast variation in the serotonin transporter promotor is associated with differing functional responses to acute serotonin re-uptake blockade. However, this did not correlate with clinical response to longer-term SSRI treatment.
SHEELER, CAMERON Q. "MECHANISMS OF ACTION OF THE ESTROGEN RECEPTOR." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin982955523.
Повний текст джерелаNorman, Jane Elizabeth. "Menstrual induction : methods and mechanisms of action." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/20065.
Повний текст джерелаBakunina, Nataliia Sergeevna. "Modelling oxidative stress in human hippocampal progenitor cells : insight into the pathogenesis of depression and antidepressants action." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/modelling-oxidative-stress-in-human-hippocampal-progenitor-cells-insight-into-the-pathogenesis-of-depression-and-antidepressants-action(eeb5d246-5d69-4d5f-bb53-8e09ac5cab93).html.
Повний текст джерелаBrowning, Michael. "The mechanisms and effects of modifying attentional biases to threatening information." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:26959079-8f02-4347-b398-1b8347b64a92.
Повний текст джерелаOstrowski, Stephen M. "Pleiotropic mechanisms of statin action in Alzheimer's Disease." Cleveland, Ohio : Case Western Reserve University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1190669698.
Повний текст джерелаJohnston, H. P. "The mechanisms of action of thiopurine nucleotide prodrugs." Thesis, University of East Anglia, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356608.
Повний текст джерелаJenkinson, Stephen. "Molecular mechanisms of lithium action on phosphoinositide signalling." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/35263.
Повний текст джерелаOstrowski, Stephen M. "Pleiotropic Mechanisms of Statin Action in Alzheimer's Disease." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1190669698.
Повний текст джерелаSmyth, Christopher David. "Paracrine mechanisms of gonadotrophin action on the ovary." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/20805.
Повний текст джерелаDagli, Deniz. "Laboratory Investigations of Frost Action Mechanisms in Soils." Licentiate thesis, Luleå tekniska universitet, Geoteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-64184.
Повний текст джерелаDvorakova, Katerina. "Mechanisms of imexon action in human myeloma cells." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/289132.
Повний текст джерелаRuzvidzo, Oziniel. "Plant Natriuretic Peptides - Elucidation of the Mechanisms of Action." Thesis, University of the Western Cape, 2009. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_5854_1285860491.
Повний текст джерелаSeveral lines of cellular and physiological evidence have suggested the presence of a novel class of systemically mobile plant molecules that are recognized by antibodies generated against vertebrate atrial natriuretic peptides (ANPs). Functional characterization of these immunoanalogues, referred to as immunoreactive plant natriuretic peptides (irPNPs) or plant natriuretic peptides (PNPs), has shown that they play important roles in a number of cellular processes crucial for plant growth and maintenance of cellular homeostasis. Although the various biological roles of PNPs in plants are known, their exact mode of action remains elusive. To elucidate the mechanisms of action for these immunoanalogues, we have prepared a biologically active recombinant PNP from Arabidopsis thaliana (AtPNP-A) and the biological activity was demonstrated by showing its ability to induce water uptake into Arabidopsis thaliana protoplasts. In addition, the molecule was shown to downregulate photosynthesis while at the same time up-regulating respiration, transpiration as well as net water uptake and retention capacities in the sage Plectranthus ecklonii. Further analysis of the recombinant AtPNP-A indicated that the peptide can induce systemic response signalling though the phloem. A recombinant Arabidopsis wall associated kinase-like protein (AtWAKL10) that has a domain organization resembling that of vertebrate natriuretic peptide (NP) receptors was also partially characterized as a possible receptor for the recombinant AtPNP-A. Vertebrate NP receptors contain an extracellular ligand-binding domain and an intracellular guanylate cyclase (GC)/kinase domain and signal through the activity of their GC domain that is capable of generating intracellular cGMP from GTP. The structural resemblance of AtWAKL10 to vertebrate NP receptors could suggest a functional homology with receptor molecules and it is conceivable that such a receptor may recognize PNPs as ligands. The characterization of the recombinant AtWAKL10 showed that the molecule functions as both a GC and a kinase in vitro. This strengthened the suggestion that AtWAKL10 could be a possible AtPNP-A receptor especially considering the fact that AtPNP-A applications to plant cells also
trigger cGMP transients. Furthermore, a bioinformatic analysis of the functions of AtPNP-A and AtWAKL10 has inferred both molecules in plant pathogen responses and defense mechanisms, thus indirectly functionally linking the two proteins.
Ntanios, Fady Y. "Cholesterol lowering efficacy of plant sterols : mechanisms of action." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0018/NQ44534.pdf.
Повний текст джерелаRousseaux, Maxime. "Understanding Parkinson's Disease: Mechanisms of Action of DJ-1." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22904.
Повний текст джерелаFox, Mary Elizabeth. "Mechanisms of action of anticancer DNA topoisomerase II poisons." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239716.
Повний текст джерелаLloyd, Jeffrey Douglas. "The mechanisms of action of boron containing wood preservatives." Thesis, Imperial College London, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284132.
Повний текст джерелаRoelofs, Anke. "Anti-tumour mechanisms of action bisphosphonates and bisphosphonate analogues." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436994.
Повний текст джерелаMcClelland, David. "Mechanisms of action of pregabalin on cultured sensory neurones." Thesis, University of Aberdeen, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408955.
Повний текст джерелаMorrow, Dympna Mary Paula. "Tumour promotion : mechanisms of action and modes of prevention." Thesis, University of Ulster, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322414.
Повний текст джерелаPetroff, Brian Kelli. "Mechanisms of Hormone Action in the Porcine Corpus Luteum /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487934589976858.
Повний текст джерелаBerger, Olivier. "Synthesis of antimalarial agents with new mechanisms of action." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20034.
Повний текст джерелаThe objective of my PhD work was the synthesis of new antimalarial agents in order to develop a new chemotherapy to fight the emerging multi-drug resistant strains of Plasmodium falciparum malaria. Our choice has been the development of three new series of drugs: quinolones which inhibit the mitochondrial respiration process, benzamidines which inhibit hemozoin formation and alkylamidines which block phospholipid metabolism. Within the O'Neill group (Liverpool), the first part of my work has been focussed on the synthesis of 4-quinolone derivatives, varying the side chain (chapter II). The second part of my work has been the synthesis of dibenzamidine derivatives, varying the heterocyclic linker (chapter III). Within this work, the linker was modified in the following ways: alkoxy chain of pentamidine was replaced by the corresponding heterocycle to give four different series of compounds (thiazole, triazole, furane or aziridine). Three different parameters were studied for these derivatives: position of the amidine function on the aromatic ring, the angle between the two benzamidines and the position of the heterocyclic ring in the molecule. For these drugs, in vitro antimalarial activities have been measured. Within the Durand group (Montpellier), the first part of my work has been focussed on the synthesis of derivatives varying the linker of the bis-C-alkylamidines and introducing an aromatic ring in the polar head of the reversed amidines. The aim was to study the influence of the aromatic ring on the antimalarial activity of the drugs as well as the development of their prodrugs (chapter IV). For all these drugs and prodrugs, in vitro and in vivo antimalarial activities have been measured. The second part of my work has been based on the stability and bioconversion studies of different asymmetrical prodrugs (chapter V). The different conditions used for these studies have been optimised on the pentamidoxime
Simmons, Michele LeAnn. "Mechanisms of dynorphin release and action in the hippocampus /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/6306.
Повний текст джерелаVainio, Petri. "Molecular mechanisms of action and activation of lipoprotein lipase." Helsinki : Societas Scientiarum Fennica, 1985. http://catalog.hathitrust.org/api/volumes/oclc/23065316.html.
Повний текст джерела