Добірка наукової літератури з теми "Antiarthritic agents; Organogold compounds – Synthesis"

Background: Cancer is a major cause of death all over the globe. Controlling cell division byinhibition of mitosis is the most successful clinical strategy for cancer treatment. The developmentof novel anticancer agents is the most important area in medicinal chemistry and drug discoveryresearch. Thiazolidine is the multifunctional nucleus which shows a number of pharmacologicalactivities like anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, antidiabetic,antihyperlipidemic and antiarthritic. Methods: In a present study series of 2-substituted-3-(1H-benzimidazole-2-yl)-thiazolidin-4-ones were designed, synthesized by the microwave-assisted system, and characterized bymelting point, IR, 1H NMR, and mass spectroscopy. All the newly synthesized compoundswere examined for their in vitro anticancer activity against breast cancer cell line MCF-7 bySulforhodamine B (SRB) assay. Results: The compounds AB-12 (GI50: 28.5 μg/ml) and AB-6 (GI50: 50.7 μg/ml) exhibitedsignificant cell growth inhibitory activity. Conclusion: These results indicate that compound AB-12 and AB-6 as related polo-like kinase1inhibitors compounds could be lead compounds for further development of anticanceragents.

Background: A plant is a reservoir of potentially useful active chemical entities which act as drugs as well as intermediates for the discovery of newer molecules and provide newer leads for modern drug synthesis. The demand for new compounds in the field of medicine and biotechnology is centuries old and with a rise in chronic diseases and resistance to existing drugs in the field of anti-infective agents, the chemicals obtained from plant sources have been an area of attraction. The whole plant has possessed multiple pharmacological activities. This is scientifically established by in-vivo and in-vitro studies. Methods: Various electronic databases such as PubMed, Science Direct, Scopus and Google were searched to collect the data of the present review. All the collected information is categorized into different sections as per the aim of the paper. Results: Fifty-six research and review papers have been studied and were included in this review article. After a detailed study, we provide a significant description of various phytochemicals present in Nyctanthes arbor-tristis Linn., which is responsible for various pharmacological activities. Twenty of studied articles gives a general introduction and ethnobotanical information about the plant, two papers contained microscopic detail of leaf and fruit. Twenty papers contained information about the phytoconstituents present in different parts of Nyctanthes arbor-tristis plant and fourteen articles reported pharmacological activities like antioxidant, anti-inflammatory, antiarthritic, antimicrobial and immunobiotic activity. Conclusion: This review explores the published research work comprising the ethnobotanical description of the subjected plant, distribution, phytochemical profile, and arthritis-related pharmacological activities.

Aims to synthesize a range of novel triorganophosphinegold(I) 6-mercaptopurinate complexes and to evaluate their potential anti-arthritic activity
Thesis (M.Sc.) -- University of Adelaide, Dept. of Chemistry, 1994

Includes addendum attached to front cover.
Includes bibliographical references.
x, 1 v. (various pagings) : ill. (some col.) ; 30 cm.
Title page, contents and abstract only. The complete thesis in print form is available from the University Library.
Reports the preparation of mononuclear triorganphosphinegold(I) mercaptobenzoic acids, where x = 2,3 or 4, R = alkyl or aryl, and Y is a bridging alkyl or ferrocene group. Demonstrates that the solid state chemistry of phosphinegold(I) thiolates remains difficult to predict when competing intra- and inter-molecular forces are present.
Thesis (Ph.D.)--Adelaide University, Dept. of Chemistry, 2001

Includes addendum attached to front cover.
Includes bibliographical references.
x, 1 v. (various pagings) : ill. (some col.) ; 30 cm.
Reports the preparation of mononuclear triorganphosphinegold(I) mercaptobenzoic acids, where x = 2,3 or 4, R = alkyl or aryl, and Y is a bridging alkyl or ferrocene group. Demonstrates that the solid state chemistry of phosphinegold(I) thiolates remains difficult to predict when competing intra- and inter-molecular forces are present.
Thesis (Ph.D.)--Adelaide University, Dept. of Chemistry, 2001