Дисертації з теми "Anévrisme de l'aorte abdominale (AAA)"
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-40 дисертацій для дослідження на тему "Anévrisme de l'aorte abdominale (AAA)".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте дисертації для різних дисциплін та оформлюйте правильно вашу бібліографію.
Toungara, Mamadou. "Contribution à la prédiction de la rupture des Anévrismes de l'Aorte Abdominale (AAA)." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00623979.
Повний текст джерелаBartoli, Michel. "Eléments de physiopathologie et validation d'une technique de mesure par IRM des anévrysmes de l'aorte abdominale dans un modèle expérimental murin." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5011/document.
Повний текст джерелаAbdominal aortic aneurysms occur in 5-9% of the population over the age of 65, and rupture of these aneurysms cause every year at least 15,000 deaths. Although most AAAs are small and asymptomatic, their diameter typically increases over time and about 60% eventually require surgical repair. To date, no therapy can slow or stop the growth of small aneurysms. The aneurysmal wall is characterized by chronic inflammation and tissue remodeling involving synthesis and destruction that leads to the loss of elastin. All these elements are present in the elastase model of aneurysm in mice. While many data have been accumulated on the involvement of metalloproteinases in the degradation of the extracellular matrix, the role of serine proteases has received much less interest. Using this model in mice cathepsin S and cathepsin C knockout, we have shown that their presence was essential for aneurysmal development. We also showed that it was possible to block the model using E64, an inhibitor of cathepsins. Taken together these data suggest that cathepsins play a role in the initiation of the inflammatory reaction and that cathepsins are a potential way of research for the development of medication which could slow down the AAAs growth. In order to block by pharmacological means the model, we developed the possibility to infuse doxycyline directly on the aneurysm. These studies showed that it was possible to block the model with an infusion of local doxycycline without blood levels of doxycycline. This experimental work opens the way for the development of drug-eluting stent graft, i.e. a stent graft able to infuse an active product which can stabilize the wall of the aneurysm
Mellak, Safa. "Trafic monocytaire dans l'anévrisme de l'aorte abdominale." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05S013/document.
Повний текст джерелаCardiovascular diseases are the first cause of mortality around the industrialized world with a continuous increase in their incidence along with the expansion of the major risk factors such as aging, obesity and diabetes. In abdominal aortic aneurysm (AAA), the presence of inflammatory infiltrates, and particularly monocytes/macrophages, has underscored the contribution and importance of immuno-inflammatory responses in aneurysmal degeneration. It is one of the most common diseases of the abdominal aorta and presents a major health problem. The importance of macrophages has recently been highlighted by a number of evidence, which are the main population observed within the site of aneurysm, are believed to derive from circulating monocytes although no direct evidence has been provided to date. Recent evidence has shown that their accumulation is particularly enhanced in the early onset of AAA in mice, and that the inhibition of CCR2/ MCP1 signaling as well as the early depletion of circulating monocytes, are protective. Hence, it seems crucial to understand the mechanisms of monocyte recruitment in the initiation and progression of AAA. In this PhD project with a particular interest in abdominal aortic aneurysm, we were particularly interested in understanding the trafficking behavior of monocyte subsets in AAA and their role in disease pathogenesis. Using a mouse model of aneurysm induction in ApoE-/- mice, we showed that Ang II triggered the mobilization of Ly-6Chigh, and to a lesser extent Ly-6Clow monocytes, from the spleen and their consequent recruitment in the aorta. Spleen removal or B lymphocyte deficiency in Apoe-/- mice similarly impaired early monocyte mobilization in response to Ang II and protected against AAA development, independently of blood pressure. Reconstitution of Apoe-/- Rag-/- mice with total splenocytes but not with B-Cell depleted splenocytes restored monocyte mobilization in response to Ang II and enhanced susceptibility to AAA. Taken together, this study provides novel mechanistic insights on the early events involved in AngII-induced AAA formation. It highlights the role of the splenic monocyte reservoir in this process and identifies an intriguing role for B lymphocytes in mediating AngII-induced early and transient mobilization of splenic monocytes. Nevertheless, further understanding of the molecular mechanisms that underlie such interactions is likely to lead to the identification of effective therapeutic targets
Steinmetz, Eric. "Anévrysmes expérimentaux de l'aorte abdominale : mécanismes et relation avec les dyslipoprotéinémies." Dijon, 2006. http://www.theses.fr/2006DIJOMU06.
Повний текст джерелаMa, Qixiang. "Deep learning based segmentation and detection of aorta structures in CT images involving fully and weakly supervised learning." Electronic Thesis or Diss., Université de Rennes (2023-....), 2024. http://www.theses.fr/2024URENS029.
Повний текст джерелаEndovascular aneurysm repair (EVAR) and transcatheter aortic valve implantation (TAVI) are endovascular interventions where preoperative CT image analysis is a prerequisite for planning and navigation guidance. In the case of EVAR procedures, the focus is specifically on the challenging issue of aortic segmentation in non-contrast-enhanced CT (NCCT) imaging, which remains unresolved. For TAVI procedures, attention is directed toward detecting anatomical landmarks to predict the risk of complications and select the bioprosthesis. To address these challenges, we propose automatic methods based on deep learning (DL). Firstly, a fully-supervised model based on 2D-3D features fusion is proposed for vascular segmentation in NCCTs. Subsequently, a weakly-supervised framework based on Gaussian pseudo labels is considered to reduce and facilitate manual annotation during the training phase. Finally, hybrid weakly- and fully-supervised methods are proposed to extend segmentation to more complex vascular structures beyond the abdominal aorta. When it comes to aortic valve in cardiac CT scans, a two-stage fully-supervised DL method is proposed for landmarks detection. The results contribute to enhancing preoperative imaging and the patient's digital model for computer-assisted endovascular interventions
Mayade, Frédéric. "Les anévrysmes de l'aorte abdominale sous-rénale : épidémiologie, clinique, traitement chirurgical et résultats : à propos de 132 cas." Bordeaux 2, 1990. http://www.theses.fr/1990BOR23046.
Повний текст джерелаGaillard, Emmanuel. "Etude expérimentale et numérique des écoulements dans les anévrismes de l'aorte abdominale." Aix-Marseille 2, 2006. http://theses.univ-amu.fr.lama.univ-amu.fr/2006AIX22030.pdf.
Повний текст джерелаThe goal of this study is to determine complementary criterions to existing morphological criterions justifying the surgical operation to treat abdominal aortic aneurysms (A. A. A. ), that are not reliable. The realization of this goal goes through the characterization of fluids dynamics inside A. A. A. . Long et al. (2004) showed that beyond a diameter of 5 cm, the A. A. A. Wall became compliant again. To study influence of this compliance, first of all, we set up an experimental study, in which we compared two models of A. A. A. , one rigid and one soft. Afterwards, we realized numerical simulations in order to get to parietal haemodynamic parameters. These two studies showed the influence of the wall compliance, as well as the influence of haemodynamic conditions on dynamics inside A. A. A. . The compliance of the aneurysmal wall might become another criterion to justify surgical intervention
Meynier, Isabelle. "Ruptures cloisonnées des anévrysmes de l'aorte abdominale sous-rénale, à propos de 2 observations." Bordeaux 2, 1996. http://www.theses.fr/1996BOR2M133.
Повний текст джерелаGonzalez, Michèle. "A propos d'un cas de rupture spontanée d'un anévrysme de l'aorte abdominale dans le jéjunum ( avec revue de la littérature)." Bordeaux 2, 1991. http://www.theses.fr/1991BOR2M095.
Повний текст джерелаAcosta, Martin Adelina Elena. "Recherche de biomarqueurs de l'anévrysme de l'aorte abdominale." Phd thesis, Université du Droit et de la Santé - Lille II, 2009. http://tel.archives-ouvertes.fr/tel-00447240.
Повний текст джерелаLareyre, Fabien. "Création d’un nouveau modèle murin d’anévrisme de l’aorte abdominale." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://theses.univ-cotedazur.fr/2018AZUR4073.
Повний текст джерелаAbdominal aortic aneurysm (AAA) is associated with extremely high morbidity and mortality rates. The only curative treatment relies on surgery as no drug has proven yet its efficacy to cure the disease. A better understanding of pathophysiological mechanisms involved in AAA development would help to identify new therapeutic targets. Even though current experimental animal models are useful to address this question, none of them perfectly mimics human disease. The aim of this study was: 1/ Create and characterize a new murine model of AAA based on topic application of elastase associated with systemic TGFβ neutralization. 2/ Study the effect of IL-1β in this model. We report that TGFβ neutralization in C57Bl6j male mice increased aneurysmal aortic dilatation induced by elastase and favored aortic rupture. This was associated with major vascular remodeling including the degradation of extracellular matrix, the infiltration of inflammatory cells in the aortic wall, the formation of an intraluminal thrombus and the increase of neoangiogenesis. Synchrotron-based ultrahigh ex-vivo resolution imaging revealed a wall disruption with no medial dissection culminating in fatal transmural aortic wall rupture. The gene expression of several cytokine including IL-1β was increased in the aortic wall. The effect of IL-1β was investigated using IL-1β-/- mice or using systemic injection of monoclonal anti-IL-1β antibody. IL-1β-/- mice were protected against aortic dilatation and aortic rupture after application of elastase associated with TGFβ neutralization. However, the injection of anti-IL-1β antibody did not limit the aortic dilatation and neither prevented the aortic rupture. In this study, we created a new murine model of AAA which reproduces the main pathophysiological human features. The genetic invalidation of IL-1β, but not its blockade after disease initiation prevented AAA dilatation and rupture, suggesting the role of this cytokine in the early stages of AAA development
Raffort, Juliette. "Étude du rôle des monocytes / macrophages et des micro-ARNs dans les anévrismes de l’aorte abdominale." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://theses.univ-cotedazur.fr/2018AZUR4082.
Повний текст джерелаAbdominal aortic aneurysm (AAA) is a major public health concern and is associated with extremely high rates of mortality in case of aortic rupture. AAA is most often associated with atherosclerosis and cardiovascular risk factors, except diabetes that may rather play a protective role in the disease. Even though several studies have highlighted an infiltration of macrophages and changes of the expression of micro-RNAs in the aneurysmal wall, their role in AAA is still not fully understood. While experimental animal models are very useful to address this question, none of them perfectly mimics human pathophysiology. We recently created a new murine model of AAA based on topic application of elastase on the aorta associated with systemic TGFβ neutralization which reproduces the main human features of AAA and leads to fatal aortic rupture. The aims of this study were: -1/ Characterize the phenotype of monocytes/ macrophages in this murine model of AAA. -2/ Study the expression of micro-RNAs in this model. -3/ As the mechanisms involved in the negative association between diabetes and AAA are still poorly known, the third goal was to mount a clinical study to compare the expression of micro-RNAs between diabetic and non-diabetic patients with AAA. Topic application of elastase associated with systemic TGFβ neutralization in C57/Bl6j male mice led to a significant increase of macrophage infiltration in the aneurysmal tissue. This was associated with changes of the gene expression of the markers of the pro-inflammatory macrophages, called “M1” and of the macrophages involved in wound healing, called “M2”. To investigate the role of macrophages in this model, we used liposomes containing clodronate injections to deplete these cells. This led to significant decrease of the aortic dilatation and prevented rupture. This was associated with a better preservation of the extracellular matrix and significant changes in the gene expression of the markers of macrophages including arginase-1 (ARG1), a molecule involved in would healing. The proportion of macrophages expressing ARG1 increased with the severity of the AAA. At last, TGFβ neutralization led to a significant decrease of a population of macrophages involved in fibrosis, called “Sat-Mono”. This study highlighted the role and the phenotypic changes of macrophages during AAA development. We then analyzed the expression of 752 micro-RNAs in the aneurysmal aortic tissue which allowed identifying the micro-RNAs whose expression varied in the murine model. At last, the expression of micro-RNAs was investigated in patients with AAA. We compared the expression of micro-RNAs between diabetic and non-diabetic patients with AAA. This pilot study led to the identification of micro-RNAs that could potentially represent new targets involved in the negative association between diabetes and AAA
Wang, Yufei. "Modélisation de la compliance de l'aorte dans le cas de pathologies de type anévrisme." Thesis, Dijon, 2015. http://www.theses.fr/2015DIJOS038/document.
Повний текст джерелаThe Abdominal Aorta Aneurysm (AAA) is a pathology that is defined by a localized and permanent dilation of the artery and which involves over 8.8% of the seniors. Currently, when a patient has a dilatation of the aorta leading to a surgery because of the rupture risk, the therapeutic decision is made depending on the diameter of the aneurysm. To determine this diameter, it is usually conducted an examination by medical imaging (ultrasound, CT, MRI...). However, it notes that the diagnosis can’t be satisfied with a single dimensional measurement face to induced risks: first of all, when the diameter exceed a certain growth, the risk of rupture can reach 50% but more than 5% of surgical procedures may cause the patient's death. Other metrics such as compliance of the artery can be used for the decision for surgery. Compliance corresponds to a precise definition by cardiologists: this is a quantity that characterizes the deformability, describing the ability of aorta to distend under the influence of blood pressure. From our point of view, this concept is insufficient because, generally, in the case of an aneurysm, rupture is highly localized because of the complexity of the shape. It is therefore necessary to extend its definition in a quantity not localized at a section or a specific location but to the whole wall. Diagnostics methods will be more reliable if they can determine localized compliance. From a mechanical standpoint, determining compliance is thus transformed into the measurement of localized parietal elasticity of aorta. The elasticity is not a directly measurable parameter. Therefore, the problem comes down to determining the local strain of the aortic wall in the hemodynamic condition. Solving this problem is complex. Indeed, the mechanical stresses are dependent on the flow of blood, the artery surrounding organs, the material properties of the artery and the geometry of the aneurysm which are specific to each patient. At present, many numerical and experimental works is done but few studies have well correlated medical imaging techniques for the diagnostic aid. It is in this context that are my thesis in collaboration both with the Dijon University Hospital where were performed all experiments using MRI and GMedTech laboratory GMIT (Galway- Mayo Institute of Technology) in Ireland who provided the replicas and their expertise in the cardiovascular area. This work, conducted on various form of phantoms in Vitro, are intended, first to build a metrological methodology to help doctors understand and validate MRI measurements using other devices measurement, on the other hand, to improve the methods of diagnosing the abdominal aortic aneurysm. The principle of this work is to develop experimental modeling in vitro in a metrology framework and correlate the results from different measurement techniques and numerical modeling throughout a cycle reproducing the hemodynamic conditions. To consider the problem as a whole, not only the evolution of deformation representing the elasticity of the aorta should be studied, but also the evolution of soliciting flow. Therefore, in this thesis, several devices such as stereovision, Particle image velocimetry (PIV), MRI kinetic sequence but also the flow 2D and 4D were employed. Various numerical models were established to not only correlate the results with those obtained experimentally, therefore, to improve the credibility of our study, but also to be part of the aid protocol to the diagnosis that we have proposed. In the end, all the results from different experimental and numerical models have led to propose a validated and feasible diagnosis protocol based on MRI sequences. The application of this protocol on a realistic AAA complex phantom showed its feasibility. We can therefore say that the feasibility of the proposed protocol is demonstrated and that based on MRI (…)
Haulon, Stéphan. "Endoprothéses couvertes de l'aorte abdominale : fuites de type II et traitements de surface." Lille 2, 2002. http://www.theses.fr/2002LIL2MT04.
Повний текст джерелаAmblard, Anne. "Contribution à l'étude du comportement d'une endoprothèse aortique abdominale : analyse des endofuites de type I." Lyon, INSA, 2006. http://theses.insa-lyon.fr/publication/2006ISAL0088/these.pdf.
Повний текст джерелаAbdominal aortic aneurysm disease is a degenerative process whose ultimate event is the rupture of the vessel wall. The endovascular approach suffers from problems such as endoleaks. We develop a non-invasive methodology to observe the contact between the endoprosthesis and the aorta wall. On the one hand, this study provides an evaluation of the stresses generated by the blood flow. As blood is a non-Newtonian fluid, we use the Phan-Thien and Tanner model, resulting from the polymer rheology. The application of this model gives the parietal shear stress and the first normal stress difference. On the other hand, we develop an axisymmetric finite-element model of the complete system. This model takes into account the viscoelastic behaviour of the aorta. Plast2, an explicit dynamic finite element code, is used to simulate the behavior of the system. The system is subject to hydrostatic pressure and to the stresses generated by the blood flow. A coupled fluid-structure interaction is achieved
Coscas, Raphaël. "Remodelage vasculaire dans les modèles expérimentaux d'anévrysme de l'aorte abdominale." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLV025/document.
Повний текст джерелаPathophysiology of abdominal aortic aneurysms (AAA) is complex. It mainly involves hemodynamics, matrix proteolysis, oxidative stress and an immune reaction. Several experimental models have been described to explore mechanisms involved in this disease. In the present work, we explore the role of experimental models in AAA vascular remodeling. First, a literature review regarding experimental models of AAA is performed. Second, we explore the origin and the role of calcifications observed in experimental models. Third, the decellularized xenograft model is used to study the role of adaptive immunity in triggering rupture. Our review identifies main AAA models. Their major limit is aortic healing, preventing evolution toward rupture. We find that AAA calcifications co-localized with free DNA and that free DNA could induce calcifications experimentally. However, AAA growth is decreased by calcifications. The decellularized xenograft model can evolve toward rupture when pre-sensitization against the extracellular matrix is performed. Structural glycoproteins and proteoglycans seems to be the main matrix component involved in these ruptures. Experimental AAA models are major tools to study mechanisms involved in vascular remodeling
Vidal, Vincent. "Bases expérimentales de l'embolisation : des agents solides, particulaires et liquides à une nouvelle base collagénique." Aix-Marseille 2, 2007. http://www.theses.fr/2007AIX20711.
Повний текст джерелаMolina, Julien. "Etude de l’intégration physiologique et environnementale d’un capteur de pression sans fil pour application vasculaire." Paris 6, 2013. http://www.theses.fr/2013PA066223.
Повний текст джерелаFor several years, new technologies have been overrunning the medical field. New materials, electronics, robotics are integrated. Abdominal aortic aneurysms affect 2 to 6% of the population. Their bursting is fatal in more than 80% of cases. One of their treatments is to place a stent-graft to exclude the damaged artery blood pressure. After surgery, endoleak detection is required, but these controls are expensive and can be harmful to patients. Therefore, the aim of this work is to develop a wireless monitoring system. For the realization of this medical device, constraints analysis and standards are essential. The geometrical, mechanical characteristics (pseudo-static and dynamic) and the coating were quantified by comparison to reference elements. Specification tests were implemented to comply with regulation standards. Using a traction / compression testing system and a dynamic bench test designed by us, we have established the expected specifications. Different coatings were investigated by culture with endothelial cells to assess their biocompatibility and nonadhesive characteristics. This work has identified the expected specifications and allowed us to choose the components. The final size will depend on the ability to miniaturize the electronics. This integration structure for biosensors can be placed in other anatomical sites or associated with other sensors for other indications
Lareyre, Fabien. "Création d’un nouveau modèle murin d’anévrisme de l’aorte abdominale." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4073/document.
Повний текст джерелаAbdominal aortic aneurysm (AAA) is associated with extremely high morbidity and mortality rates. The only curative treatment relies on surgery as no drug has proven yet its efficacy to cure the disease. A better understanding of pathophysiological mechanisms involved in AAA development would help to identify new therapeutic targets. Even though current experimental animal models are useful to address this question, none of them perfectly mimics human disease. The aim of this study was: 1/ Create and characterize a new murine model of AAA based on topic application of elastase associated with systemic TGFβ neutralization. 2/ Study the effect of IL-1β in this model. We report that TGFβ neutralization in C57Bl6j male mice increased aneurysmal aortic dilatation induced by elastase and favored aortic rupture. This was associated with major vascular remodeling including the degradation of extracellular matrix, the infiltration of inflammatory cells in the aortic wall, the formation of an intraluminal thrombus and the increase of neoangiogenesis. Synchrotron-based ultrahigh ex-vivo resolution imaging revealed a wall disruption with no medial dissection culminating in fatal transmural aortic wall rupture. The gene expression of several cytokine including IL-1β was increased in the aortic wall. The effect of IL-1β was investigated using IL-1β-/- mice or using systemic injection of monoclonal anti-IL-1β antibody. IL-1β-/- mice were protected against aortic dilatation and aortic rupture after application of elastase associated with TGFβ neutralization. However, the injection of anti-IL-1β antibody did not limit the aortic dilatation and neither prevented the aortic rupture. In this study, we created a new murine model of AAA which reproduces the main pathophysiological human features. The genetic invalidation of IL-1β, but not its blockade after disease initiation prevented AAA dilatation and rupture, suggesting the role of this cytokine in the early stages of AAA development
Raffort, Juliette. "Étude du rôle des monocytes / macrophages et des micro-ARNs dans les anévrismes de l’aorte abdominale." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4082/document.
Повний текст джерелаAbdominal aortic aneurysm (AAA) is a major public health concern and is associated with extremely high rates of mortality in case of aortic rupture. AAA is most often associated with atherosclerosis and cardiovascular risk factors, except diabetes that may rather play a protective role in the disease. Even though several studies have highlighted an infiltration of macrophages and changes of the expression of micro-RNAs in the aneurysmal wall, their role in AAA is still not fully understood. While experimental animal models are very useful to address this question, none of them perfectly mimics human pathophysiology. We recently created a new murine model of AAA based on topic application of elastase on the aorta associated with systemic TGFβ neutralization which reproduces the main human features of AAA and leads to fatal aortic rupture. The aims of this study were: -1/ Characterize the phenotype of monocytes/ macrophages in this murine model of AAA. -2/ Study the expression of micro-RNAs in this model. -3/ As the mechanisms involved in the negative association between diabetes and AAA are still poorly known, the third goal was to mount a clinical study to compare the expression of micro-RNAs between diabetic and non-diabetic patients with AAA. Topic application of elastase associated with systemic TGFβ neutralization in C57/Bl6j male mice led to a significant increase of macrophage infiltration in the aneurysmal tissue. This was associated with changes of the gene expression of the markers of the pro-inflammatory macrophages, called “M1” and of the macrophages involved in wound healing, called “M2”. To investigate the role of macrophages in this model, we used liposomes containing clodronate injections to deplete these cells. This led to significant decrease of the aortic dilatation and prevented rupture. This was associated with a better preservation of the extracellular matrix and significant changes in the gene expression of the markers of macrophages including arginase-1 (ARG1), a molecule involved in would healing. The proportion of macrophages expressing ARG1 increased with the severity of the AAA. At last, TGFβ neutralization led to a significant decrease of a population of macrophages involved in fibrosis, called “Sat-Mono”. This study highlighted the role and the phenotypic changes of macrophages during AAA development. We then analyzed the expression of 752 micro-RNAs in the aneurysmal aortic tissue which allowed identifying the micro-RNAs whose expression varied in the murine model. At last, the expression of micro-RNAs was investigated in patients with AAA. We compared the expression of micro-RNAs between diabetic and non-diabetic patients with AAA. This pilot study led to the identification of micro-RNAs that could potentially represent new targets involved in the negative association between diabetes and AAA
Saccaro, Ludovica. "Vers l'évaluation du risque des anévrismes de l'aorte abdominale par modélisation géométrique et simulations hémodynamiques d'ordre réduit." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0025.
Повний текст джерелаThis thesis focuses on a specific pathology affecting the abdominal section of the aorta, known as abdominal aortic aneurysm (AAA). An aneurysm involves a persistent and localized weakening of the vessel wall, leading to enlargements and bulges, causing recirculation and turbulence of blood flow.Our thesis outlines a methodology for geometric modeling of abdominal aneurysms. The process involves acquiring CT images, reconstructing the aorta 3D geometry, and isolating the aneurysm. The modeling phase begins by identifying and approximating the centerline of the aortic vessel using B-spline functions. The aortic wall is then partitioned and profiled using Fourier series.To evaluate its effectiveness, the developed technique is applied to a dataset of CT scans from patients. Reconstructions obtained from the scans are also presented as examples to detail each step of the procedure. In addition, a quantitative evaluation and rationale behind modeling parameters are explained. Then, as a first application, the modeling is integrated into a registration process for clinical diagnosis and follow-up.The geometrical modeling procedure developed is used in a pipeline for hemodynamic simulations and risk assessment, employing a reduced-order modeling approach to construct a reduced solution space. Simulations, utilizing parameterized geometries, are conducted under realistic conditions, and risk indicators are computed and linked to the geometrical representation using Radial Basis Functions interpolant. Finally, predictions on risk indicators are obtained for an unknown geometry. The results, despite being promising, can be further improved by appropriately augmenting the initial dataset.To address the aforementioned scarcity of clinical data, we devised an automated workflow for generating synthetic geometries. This approach allows for the identification of relevant geometry parameters and involves machine learning to generate a virtual patient population consistent with the original data. In addition to improving the predictive capability of reduced models, the method can also be applied prospectively for in-silico trials and studies involving virtual patient populations
M'Bengue, Marie-Stella. "Conception et évaluation d'une endoprothèse vasculaire par impression 3D pour le traitement des anévrismes complexes de l'aorte abdominale." Electronic Thesis or Diss., Université de Lille (2022-....), 2022. http://www.theses.fr/2022ULILS057.
Повний текст джерелаEndovascular repair (EVAR) of an abdominal aortic aneurysm (AAA) involves the placement into the aneurysm of a stent graft (SG) by minimally invasive surgery. This procedure prevents rupture of the damaged tissue involved in an AAA, defined as a localized diameter dilation of the aorta. When the upstream portion of the aneurysm includes the peripheral renal and/or visceral arteries, the AAA is qualified as complex. In this case, the deployed SG is said “fenestrated”, in other words, perforated at the site of junctions to the peripheral arteries. Management of a complex AAA becomes more limiting as the fenestrated SG will be custom designed to match the anatomy of the aneurysm and the position of the peripheral arteries of the patient. This implies a manufacturing delay of several weeks, limits the management to stable aneurysms and excludes emergency situations. In this context, 3D printing (3DP) is of considerable interest for the fabrication of custom-made SGs in a very short time frame. Thus, the objective of this thesis work is to design a SG prototype by 3D printing of a medical grade thermoplastic polyurethane (TPU) (thermoplastic elastomer). The present work will validate the manufacturing process and the functionality of our 3DP-SG for its final application as an implantable medical device.First, the impact of the manufacturing process on the chemical, physical and physicochemical properties of TPU was studied at each step, from the pellets to the gamma-ray sterilization of a graft manufactured by fused filament deposition (FDM). In vitro preliminary evaluation of the cytotoxicity and hemocompatibility of TPU was carried out after the 3D printing and sterilization step. Aging of TPU under extreme oxidizing conditions was performed to predict the evolution of its properties in the long term. Subsequently, a design strategy for an endovascular implantable prototype was developed. The properties of said prototype were characterized by different techniques (SEC, TGA, DSC, FTIR, SEM, goniometry, uniaxial traction, ...). Its biological properties were evaluated in vitro by tests of cytocompatibility, hemocompatibility and contact with macrophages for 24 hours (acute inflammation). Moreover, the evolution of its physicochemical and mechanical properties was evaluated by in vitro aging studies.The characterization of the chemical, physical and physicochemical properties of TPU enabled the validation of a FDM printing manufacturing route and gamma ray sterilization of a crimpable SG prototype. The in vitro biological evaluation showed the non-cytotoxicity of the SG prototype by the extraction method. Moreover, the prototype was found to be weakly hemolytic and the platelets adhered on its surface were not activated. The low secretion of cytokines (IL-6 and TNF-α) upon contact with inactivated macrophages showed that the SG prototype does not exhibit a pro-inflammatory characteristic. Finally, aging studies showed an impact on the mechanical and surface properties of our SG prototype without compromising its functionality. Subsequently, the design strategy could evolve towards a functionalization of the SG prototype in order to prevent infections and thrombosis responsible for 2% and 6% of postoperative complications respectively
Franck, Grégory. "Altération du développement endothélial dans les anévrysmes de l'aorte abdominale : physiopathologie et Cibles Thérapeutiques." Thesis, Paris Est, 2013. http://www.theses.fr/2013PEST0108.
Повний текст джерелаSummary not transmitted
Rouer, Martin. "Traitement pharmacologique des anévrismes de l'aorte abdominale sous rénale. Intérêt du développement de modèle murins d'exclusion endovasculaire. L'avenir est-il au développement d'endoprothèses actives ?" Thesis, Normandie, 2017. http://www.theses.fr/2017NORMR120/document.
Повний текст джерелаAbdominal aortic aneurysm (AAA) pathophysiology is multifactorial. From the athero-thrombotic plaque to a threatening aneurysm, hemodynamic, proteolysis, oxidation and inflammation play a complex but interdependent role. No pharmacological treatment has yet proved to be efficient. In this work, we study 2 potential pharmacological targets, and develop a murine model of endovascular abdominal aneurysm repair (EVAR). Rapamycine is used in oncology. Its anti-inflammatory, anti-proliferative and antiangiogenic properties stabilized aneurysm progression on an established AAA. AZD9668 is an elastase selective inhibitor. Secreted by neutrophils, this protease plays a key role in aneurysmal pathophysiology. Its therapeutic benefits have been study on a murine AAA model potentiated by Porphyromonas Gingivalis systemic injection, maintaining inflammatory reaction and wall proteolysis. Then, we developed a murine endovascular aneurysm exclusion model. EVAR raised new concern, underlining the crucial role of the thrombus biological activity. Endovascular AAA exclusion on big animals is complex and expensive. We hence described the technic on a rat AAA well known model. Pharmacological AAAs treatment has proved to be efficient on murine models, but is hard to transpose to humans because of systemic side effects. An endoluminal treatment carrying active drugs, and delivered in-situ, could durably stabilize AAAs
Alric, Pierre. "Chirurgie aortique et fonction rénale." Montpellier 1, 2002. http://www.theses.fr/2002MON1T018.
Повний текст джерелаOtt, Franck. "Développement et optimisation d'endoprothèses vasculaires." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAI019.
Повний текст джерелаAbdominal aortic aneurysm (AAA) is a pathology that must be repaired by a surgical procedure to avoid a rupture, lethal in most of the cases. Endovascular aneurysm repair (EVAR) is a non-invasive procedure, allowing the deployment of a stent-graft inside the aneurysmal sac. Nevertheless, clinical feedback currently available for stent-grafts show that many complications after surgery – migrations, thrombosis, endoleaks, rupture – are closely linked to the mechanical behaviour of the stent-grafts, which is heterogeneous and very far from the one of the aorta. This behaviour is induced by the design of current stent-grafts, made by assembling a textile body with an exoskeleton sutured on the latter. These post-operative problems frequently lead to a second operation of the patient, which drastically reduces the benefits of endovascular surgery.In-vivo, stent-grafts are submitted to various loadings: inflation induced by the blood pressure, compression due to surrounding organs, but also bending due to the patient motion or the aorta tortuosity, etc. As far as possible, the mechanical behaviour of stent-grafts must also be as closed as possible to the original aorta, to avoid mechanical discontinuities that may be responsible for intimal hyperplasia.In this context, the principal purpose of this thesis is to contribute to the development and the optimization of vascular endoprostheses, resulting from an innovative manufacturing technology whose target is to insert a helical metallic wire in NiTi within a knitted PET textile body. This technology allows to build homogeneous textile tubes without any exo-skeleton. In order to optimize these structures, various experimental tests coupled with 2D or 3D imaging techniques – Synchrotron and laboratory X-ray micro-tomography – have been developed to characterize the mechanical behavior as well as permeability of these tubes. The results of these different tests are compared to experimental or numerical results of the literature regarding the native aortic tissue, as well as data concerning market products. The ultimate goal of this work is to provide new stent-grafts whose behavior is close to the native abdominal aorta, and which limit current post-operative problems
Gopalakrishnan, Shyam Sunder. "Dynamics and Stability of Flow through Abdominal Aortic Aneurysms." Doctoral thesis, Université de Lyon 1, Ecole Centrale de Lyon, Lyon, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/245358.
Повний текст джерелаSpear, Rafaëlle. "Analyse transcriptomique des cellules vasculaires isolées du tissu anévrysmal de l'aorte abdominale sous-rénale chez l'homme." Thesis, Lille 2, 2014. http://www.theses.fr/2014LIL2S050/document.
Повний текст джерелаAbdominal aortic aneurysm (AAA) is a public health problem, which mainly affects men older than 65 year. AAA are usually asymptomatic with a natural evolution towards rupture associated with a high mortality rate. Among non coding ribonucleic acids (RNAs), microRNAs are stable in tissue and biofluids and are interesting candidates for the search of biomarkers. Inflammation, extracellular matrix (ECM) degradation and media rarefaction are involved in AAA. Many inflammatory cells are involved in AAA. Anoikis is an apoptosis secondary to a cell detachment from ECM and is responsible for rarefaction of smooth muscle cells (SMC). Differential proteomic analysis of cultured SMC from AAA patients was performed in the laboratory and highlighted the overexpression of a disintegrin and metalloproteinase with thrombospondin motif of type 5 (ADAMTS 5) in SMC of AAA patients. Isolation of cells with laser microdissection allows to keep their phenotype and to find potential markers that may be masked by global tissue analysis.The aim of my PhD work was to perform a global miRNA screening of cells isolated from human aneurysmal wall and an analysis targeted on ADAMTS 5, a metalloprotease with an enzymatic activity on ECM proteins. The main objectives were a better understanding of AAA and the identification of new biomarkers.The distribution of cells in the aneurysmal wall was studied by immunohistochemistry in human aneurysmal and healthy aortic samples. Once located, the cells were isolated by laser microdissection and screened for miRNAs by microarrays. Differential expression of selected miRNAs was quantified by PCR in the cells isolated by laser microdissection and in whole aortas. They were then compared in plasma of AAA patients and atherosclerotic patients without AAA by quantitative PCR to identify potential biomarkers.In AAA, the M1 proinflammatory macrophages were located in the adventitia and the M2 antiinflammatory macrophages in the intraluminal thrombus; the type B lymphocytes were organized in tertiary lymphoid organs (ATLOs) in 11/20 of analysed samples. SMC were rare and restricted to the media. Among the 850 miRNAs tested on microarray, 205 miRNAs were detected in isolated cells. MiR-29b and let-7f were upregulated in plasma of AAA patients, and thus are potential biomarkers.The expression of ADAMTS 5 in aneurysmal SMC was evaluated by immunohistochemistry of healthy and aneurysmal aortic wall and quantified by Western blot in isolated SMC from healthy and aneurysmal wall.Two aneurysmal SMC morphotypes were identified: a rounded morphotype positive for caspase 3, an apoptotic marker, and a spindle-shaped morphotype similar to the healthy aortic SMC. The expression profile of ADAMTS 5 subunits was different in rounded SMC compared to aneurysmal and healthy spindle-shaped SMC. In vitro induction of apoptosis of SMC was established in order to study the mechanisms involved in ADAMTS 5 expression in AAA and their consequences on enzymatic actions.The global transcriptomic screening of aneurysmal cells isolated by laser microdissection has identified potential markers of AAA, miR-29b and let-7f. The targeted analysis suggested that ADAMTS 5 is involved in the evolution profile of SMC towards anoikis in AAA. Further investigations will allow a better understanding of AAA pathophysiology
Gindre, Juliette. "Simulation spécifique patient de la réponse mécanique de la structure vasculaire à l'insertion d'outils lors d'une chirurgie EVAR." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSEI052/document.
Повний текст джерелаEndovascular Aneurysm Repair (EVAR) is a mini-invasive technique that is commonly used to treat Abdominal Aortic Aneurysms (AAA). It relies on the exclusion of the aneurysm sac by introducing one or more stent-grafts through the femoral arteries and deploying them inside the aneurysm. During the procedure, several tools of varying stiffness are introduced to enable the delivery of the stent graft to its deployment site. During this process, the vascular structure undergoes major deformations. Usually, these have no consequence on the smooth progress of the procedure. However, in some instances, particularly when the patient presents an unfavorable anatomical profile (major tortuousness or angulation, deep calcification, long length of the common and external iliac arteries), the deformation caused by the insertion of stiff guidewires can have major consequences. Today, their prediction relies mainly on the surgeon’s experience. Numerical simulation appears to be an appropriate tool to give the practitioner more objective and more useful indicators when planning the procedure: guiding the surgical act and making it safer using such an approach would potentially reduce the risks of intraoperative and postoperative complications. In the first step of the work, we developed a mechanical model of the aorto-iliac vascular structure and a simulation methodology to answer the mechanical problem. This patient-specific model has been parametrized based on available preoperative data. Then the second step of the work consisted in the validation of this model by confronting the simulation results to real intraoperative 3D data that were collected on 28 cases of patients operated at the University Hospital of Rennes. All the methods that were developed during this PhD were integrated in demonstration module of EndoSize® software (Therenva, France)
Salsac, Anne-Virginie. "Evolution des contraintes hémodynamiques lors de la croissance des anévrismes aortiques abdominaux." Palaiseau, Ecole polytechnique, 2005. http://www.theses.fr/2005EPXX0006.
Повний текст джерелаGiraud, Andréas. "Développement d’une approche de thérapie cellulaire de l’anévrisme de l’aorte abdominale utilisant les fibroblastes gingivaux chez la souris." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB029/document.
Повний текст джерелаAbdominal aortic aneurysm (AAA), frequently diagnosed in old patients, is characterized by chronic inflammation, vascular cell apoptosis and metalloproteinases-mediated extracellular matrix destruction. Depiste improvement in the understanding of the pathophysiology of the aortic aneurysm disease, no pharmacological treatment is available to limit dilatation and/or rupture. In the study reported here, we tested whether periadventitial allograft of GF prevented abdominal aortic aneurysmal growth and rupture in mice and investigated the mechanisms of vascular protection. In vitro, mouse GF proliferated and produced large amounts of anti-inflammatory cytokines and Timp-1, an inhibitor of metalloproteinases. When layed down in the periadventitial abdominal aorta, we documented that GF survived in vivo, proliferated and organized as a thick layer. Furthermore, GF locally produced Il-10, TGF-β and Timp-1. In an elastase-induced AAA, GF prevented both macrophage and lymphocyte infiltration, elastin degradation and aneurysm growth. Specific invalidation of Timp-1 in GF abolished the beneficial effect of cell therapy. In an Angiotensin II/anti-TGF-β model of AAA, GF cell therapy limited AAA development and prevented abdominal rupture. Gingival fibroblast is a promising cell therapy approach to inhibit aneurysmal progression and rupture through the local production of Timp-1
Lapos, Cécile. "Dissection aortique de l'adolescent d'allure idiopathique : à propos d'un cas." Bordeaux 2, 2000. http://www.theses.fr/2000BOR2M062.
Повний текст джерелаEl, Kalioubie Ahmed. "Adipokines et pathologies vasculaires humaines : anévrysmale et athéroscléreuse." Thesis, Lille 2, 2011. http://www.theses.fr/2011LIL2S018.
Повний текст джерелаObesity is associated with a higher risk of atherosclerotic cardiovascular pathologies and accordingly entails a great deal of morbidity and mortality. Central to obesity is the accumulation of large amounts of white adipose tissue, which inappropriately secretes bioactive molecules involved in a state of local and systemic low grade inflammation as well as metabolic anomalies. These molecules are the adipokines including leptin, resistin and adiponectin. An abdominal aortic aneurysm (AAA) is a localized and permanent aortic dilation, exceeding 50% of the adjacent normal aortic wall diameter. AAA has long been considered an atherosclerotic complication, a theory which has recently been challenged. Only a few studies have evaluated the prevalence and risk factors of AAA in coronary artery disease (CAD) patients. In the first part of our work, we dealt with 217 patients undergoing coronary artery bypass grafting for severe CAD. In men aged less than 75 years with a smoking history, AAA prevalence reached 24% if they had concomitant peripheral artery disease or carotid artery stenosis, vs 4.4% in the absence of either condition. AAA screening is only recommended in men, aged 65 to 75 years, with a history of smoking. Na data are available on the need for AAA screening among CAD patients. The second part of our work is a review on the prevalence and risk factors of AAA in CAD patients. Despite a limited number of studies, AAA seems to be more prevalent among CAD patients compared to the global population. Only some traditional atherosclerosis risk factors remain significantly associated with AAA (smoking, age, atherosclerosis of other vascular beds). Accordingly, AAA may not be pressed into a simple scheme as just an atherosclerotic complication. The benefit of AAA screening in this specific sub-population needs to be further assessed. Both AAA and atherosclerosis share chronic arterial wall inflammation. Hence, in the 3rd part of the current work, we measured circulating levels of the 3 main adipokines (leptin, resistin and adiponectin) and assessed their relationship with the presence of AAA among our precited severe CAD male patients. Only serum resistin levels were independently associated with AAA, and correlated with infra renal aortic diameter. This correlation disappeared in the AAA range. Eventually, resistin could be associated with AAA pathogenesis, independently of its implication in atherosclerosis – related inflammation. The fourth and final part of our work has acknowledged the role of leptin in the development of atherosclerotic carotid artery stenosis. We included 146 patients scheduled for carotid endarterectomy for asymptomatic versus symptomatic carotid artery stenosis. We reported, for the first time, that serum and intra–plaque leptin levels were significantly lower in symptomatic patients compared to asymptomatic patients. This result was confirmed by multivariate analysis. Circulating and intra plaque levels were positively correlated to a stable plaque phenotype (high collagen/macrophage ratio). In vitro, leptin induced an initial migratory response on vascular smooth muscle cells (VSMC) at the concentration range of 0 to 20 ng/mL, followed by a proliferative response (20 to 75 ng/mL). At higher concentrations (100 ng/mL), leptin brought about VSMC apoptosis. Leptin could thus play an active role in carotid plaque stabilization, via its effects on VSMC. Several conclusions can be drawn. AAA is not a mere atherosclerotic complication. On one side, resistin could actively influence the development and progression of AAA. On the opposite side, leptin could promote atherosclerotic plaque stabilization, via its effects on VSMC migration and proliferation
Mohand, Kaci Faïza. "Bioingénierie des cellules souches mésenchymateuses médullaires cultivées en 3D : application au traitement de l’anévrysme de l’aorte abdominale." Thesis, Paris Est, 2012. http://www.theses.fr/2012PEST0079.
Повний текст джерелаAbdominal aortic aneurysm (AAA) is a degenarative disease of the arterial wall, which is usually treated with a conventional surgery or an andovascular stent. Due to its high morbidity and mortality, the AAA constitutes a major public health concern. The aim of this thesis is to evaluate the imapct of OD culture of mesenchymal stem cells (MSC), in particular on their phenotype, their multipotency, their ability to repair aneurysms in vivo and to acquire a phenotype suitable to the nechanical stress they support in vitro. Optmal culture conditions in a 3D hydrogel of hyaluronic acid preserving the multipotency of MSC in vitro have been established. Under mechanical effects, reproducing those supported by the aortic wall in vivo, 2D and 3D CSM seem to preserve their multipotency. However, under such dynamic conditions, the viability of 3D CSM increases unlike that of 2D CSM. By using a rat xenograft model, the results also show that injection of 2D or 3D CSM, stabilizes the AAA and improves the mechanical strenght of the aneurysmal vessel wall. The study in rat was supplemented by an evaluation of a therapeutic cell-based approach using 3D CSM in the case of chronic false aneurysms of the isthlus in pigs. This step allowed the characterization of 3D CSM and the development of an experimental model in pigs, which allows to consider cell therapy in this model. More genrally, this work contributes to a better understanding of CSM biology and to an improvement of the approaches used in cell therapy and regenerative medicine
Lemercier, Audrey. "Développement de nouveaux textiles biomimétiques pour des prothèses vasculaires." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAI097.
Повний текст джерелаThis thesis aims at developing new biomimetic textiles to design vascular prostheses with a mechanical behavior close to the one of the host aorta, in order to reduce current post-operative problems. To define the ideal target properties, a AA mechanical model was chosen, based on a multi-layered model from the literature. The model parameters were adjusted on biaxial tensile data reported in the literature, performed on excised AA samples for three different age groups. Then, this model was implemented in a finite element code in order to simulate the mechanical behavior of the healthy aorta submitted to various mechanical loadings, both at the material's scale (uni- and biaxial tensile tests, bending) and at the structure's scale (inflation with prestretch, bending, diametric compression). Secondly, several commercial prostheses were characterized using dedicated experimental devices combined with image recordings. The prostheses were tested under the same boundary and loading conditions as the ones used in the numerical simulations. These tests showed that the actual prostheses are not fully mechanically compatible with the host aorta. In order to solve this problem, the last part of this work was dedicated to the design of new biomimetic textiles, i.e. mimicking the healthy aorta's mechanical behavior and main histologic properties (“wavy fibres” and “preferred fiber orientations”), which can be produced industrially using “warp knitting” technology. Firstly, the mechanical behavior of several PET yarns made of different titers, filament numbers and textures were characterized after several treatments (thermal, etc.). This step enabled to identify one specific yarn to produce the biomimetic textiles. Then, a first optimization of the manufacturing parameters (weave, gauge, density, etc.) was made step by step by means of several textile production and planar tests (uni- and biaxial tensile tests). Finally, several trials were conducted to design tubular structures from the optimized textiles. Two shaping methods were developed: sewed tubes / weaved tubes. The continuously “weaved tubes” production is an innovative and promising technology as far as we know. The mechanical behavior of the new tubes was characterized using inflation tests for a first assessment. More specifically, the effect of the treatments usually applied on medical textiles (cleaning, thermal treatment, coating) was tested on weaved tubes and planar textiles samples. By adjusting the parameters of the several processes - and mostly those of thermal treatments – it was possible to adjust the textiles' mechanical behavior in order to make it the closest to the AA's one
Gehin, Rahma. "Les faux anévrysmes anastomotiques (F. A. A. ) du scarpa : essai d'évaluation du rôle de l'épiplooplastie associée à la section de l'arcade fémorale dans la prévention." Bordeaux 2, 1997. http://www.theses.fr/1997BOR2M068.
Повний текст джерелаLi, Li. "Evaluation d’un effet anti-apoptotique du fibroblaste gingival et étude des mécanismes impliqués : contribution au développement d’une thérapie cellulaire de l’anévrisme de l’aorte abdominale." Paris 5, 2011. http://www.theses.fr/2011PA05T023.
Повний текст джерелаThe abdominal aortic aneurysm is a vascular disease characterized by a degradation of the extracellular matrix. It is accompanied by a decrease of smooth muscle cells (SMCs). Previous work performed in the laboratory showed that the gingival fibroblast (GF) inhibits the degradation of elastic fibers in an ex vivo artery culture model. This effect is linked to the stimulation of the synthesis of TIMP-1 by SMCs of the aortic wall by gingival fibroblast (Gogly, 2007). In order to contribute to the development of a cell therapy with GFs, it is important to know whether GFs also have a protective effect on the arterial wall cells. We first showed that the presence of GFs in co-culture with fragments of aorta, lead to a decrease of the number of apoptotic cells in the aortic wall. The treatment of aorta segments with GFs conditioned medium gave similar results. To study the mechanisms of this anti-apoptotic effect, we used cells in monolayer (a line of human fibroblast Wi26 and HUVEC). The GFs inhibit the activity of caspases 3 and 9. The inhibition of the caspase 9 activity showed that GFs modulate the mitochondrial pathway of apoptosis. This is confirmed by studies of mitochondrial membrane potential (Δψm) and the release of cytochrome c. The analysis of pro- (Bax) and anti-apoptotic (Bcl-2, Bcl-xl, Hsp27) protein expression also showed an increase of the expression of Bcl-2 and an inhibition of Bax. Next, we showed that overexpression of Bcl-2 by the GFs conditioned medium go through the FAK/Pi3K signaling pathway and the induction of phosphorylation of MAP kinase Erk1 / 2. Finally, among the various factors secreted by the GFs, we analysed the effects of TIMP-1 and TGF-beta1 using blocking antibodies. The results showed an inhibition of the expression of Bcl-2 by anti-TIMP-1 and an inhibition of the expression of Bcl-2 accompanied by a decrease of the phosphorylation of Erk1 / 2 by the antibody anti-TGF-beta1. Therefore the TIMP-1 and the TGF-beta1 contribute, at least partially, to the anti-apoptotic effects of GFs. Thus, this research permits to have a better understanding of the mechanisms of these anti-apoptotic effects of GFs and contributes to the development of a new cell therapy strategy based on GFs
Joly, Florian. "Numerical Insights for AAA Growth Understanding and Predicting: Morphological and Hemodynamic Risk Assessment Features and Transient Coherent Structures Uncovering." Thèse, 2019. http://hdl.handle.net/1866/22597.
Повний текст джерелаMajor, Annie. "Analyse des mécanismes d'échec des endoprothèses couvertes et stimulation de la formation néointimale in vitro : vers un meilleur traitement des anévrismes de l'aorte abdominale." Thèse, 2006. http://hdl.handle.net/1866/15725.
Повний текст джерелаBonneviot, Marie-Christine. "Désendothélialisation des anévrismes lors du traitement endovasculaire : une nouvelle approche pour prévenir les endofuites." Thèse, 2008. http://hdl.handle.net/1866/8086.
Повний текст джерела