Добірка наукової літератури з теми "Anchor Concrete Machinery Co"

At the outbreak of the First World War, George Russell (Æ) published a series of editorials in the Irish Homestead calling for Ireland to secure food reserves against the demands he predicted Britain would make upon Irish agricultural sectors to fuel the war effort. Irish agriculture, Russell writes, is part of a peculiar market shaped by empire: ‘Ireland is a food producing nation’; and yet ‘a machinery of export […] automatically deducts’ Irish cattle, pork, butter, milk, poultry, and eggs, ‘week by week’, while ‘week by week’ bacon, meat, flour, and other goods are imported. The machinery of war, it is implied, could easily disrupt these trade channels and trigger a scarcity crisis. Such an event would not be caused by an actual food shortage but by the unpredictable pressures of wartime markets, in which what Russell calls ‘famine prices’ would deplete food reserves. By analyzing Russell's strategic deployment of the language of colonial economics, this article argues that Russell recirculates the cultural memory of Ireland's Great Famine within Revivalist discourse in order to protest the conscription of Ireland's food reserves, rallying support for co-operatives as a matter of national defense. Co-operation dispels perceptions of Ireland as a quaint backwater of sleepy farms and reveals a competing vision of rural modernity that contrasts sharply with the terrifying military technologies and sense of a traumatic break with the past that typically anchor understandings of modernity in the era. For Russell, securing food sovereignty through self-sufficient, decentralized cooperatives could secure political sovereignty for the modern Irish nation, providing a blueprint for a new social order as geopolitical categories were re-constellated by global conflict.

The endoplasmic reticulum represents the gateway to the secretory pathway. Here, proteins destined for secretion, as well as soluble and membrane proteins that reside in the endomembrane system and plasma membrane, are triaged from proteins that will remain in the cytosol or be targeted to other cellular organelles. This process requires the faithful recognition of specific targeting signals and subsequent delivery mechanisms to then target them to the translocases present at the ER membrane, which can either translocate them into the ER lumen or insert them into the lipid bilayer. This review focuses on the current understanding of the first step in this process representing the targeting phase. Targeting is typically mediated by cleavable N-terminal hydrophobic signal sequences or internal membrane anchor sequences; these can either be captured co-translationally at the ribosome or recognised post-translationally and then delivered to the ER translocases. Location and features of the targeting sequence dictate which of several overlapping targeting pathway substrates will be used. Mutations in the targeting machinery or targeting signals can be linked to diseases.

Abstract In peroxisomal matrix protein import two processes directly depend on the binding and hydrolysis of ATP, both taking place at the late steps of the peroxisomal import cycle. First, ATP hydrolysis is required to initiate a ubiquitin-transfer cascade to modify the import (co-)receptors. These receptors display a dual localization in the cytosol and at the peroxisomal membrane, whereas only the membrane bound fraction receives the ubiquitin modification. The second ATP-dependent process of the import cycle is carried out by the two AAA+-proteins Pex1p and Pex6p. These ATPases form a heterohexameric complex, which is recruited to the peroxisomal import machinery by the membrane anchor protein Pex15p. The Pex1p/Pex6p complex recognizes the ubiquitinated import receptors, pulls them out of the membrane and releases them into the cytosol. There the deubiquitinated receptors are provided for further rounds of import. ATP binding and hydrolysis are required for Pex1p/Pex6p complex formation and receptor export. In this review, we summarize the current knowledge on the peroxisomal import cascade. In particular, we will focus on the ATP-dependent processes, which are so far best understood in the model organism Saccharomyces cerevisiae.

Thanks to the awareness created by the concrete effects of global warming and climatic irregularities, concepts such as carbon emissions, polluting gases, internal combustion engines, energy efficiency are gaining more and more importance in our lives globally. In this context, the maritime sector, which provides the transfer of 90% of global trade, has become the center of attention with its ships boasting huge machinery and has also been a subject of exhaust emission studies. The fact that approximately 70% of ship emissions occur in coastal areas requires more scrutiny of ships operating in these areas. Providing docking and departing services for ports, having small hull sizes compared to other ships but featuring big machinery in terms of power output (kW), port tugboats are a serious source of emissions. As a first in this literature, the present study aimed to make a 3-month emission inventory of port tugs in Izmit Bay, where Turkey’s largest shipping activities take place, and to compare it with emission studies for other ships. In the study period, port tugs’ emissions of CO2, NOX, SOX, VOC, PM, CO were calculated to be 7,398.88 tonnes, 121.09 tonnes, 66.43 tonnes, 2.13 tonnes, 4.27 tonnes, and 5.77 tonnes, respectively. This suggests that port tugs have a significant place among ship types in terms of producing exhaust emissions.

We have investigated the role of glycosylphosphatidylinositol (GPI) anchors in forward secretory trafficking using African trypanosomes as a model system. Soluble GPI-minus forms of variant surface glycoprotein (VSG), in which the C-terminal GPI-addition peptide signal is deleted, are secreted from transformed procyclic trypanosomes with 5-fold reduced kinetics, relative to matched GPI-anchored constructs. Cell fractionation and immunofluorescence localization studies indicate that the GPI-minus VSG reporters accumulate in the endoplasmic reticulum (ER). This transport defect is specific, since overexpression of GPI-minus VSG has no effect on the rate of transport of a second soluble secretory reporter (BiPN) when co-expressed in the same cells. Two results suggest that delayed forward transport cannot be accounted for by failure to fold/assemble in the absence of a GPI anchor, thereby leading to prolonged association with ER quality-control machinery. First, no evidence was found for elevated association of GPI-minus VSG with the ER molecular chaperone, BiP. Secondly, newly synthesized GPI-minus VSG is dimerized efficiently, as judged by velocity-sedimentation analysis. GPI-dependent transport is not confined to the VSG reporters, because a similar dependence is found with another trypanosomal GPI-anchored protein, trans-sialidase. These findings suggest that GPI structures act in a positive manner to mediate efficient forward transport of some, and perhaps all, GPI-anchored proteins in the early secretory pathway of trypanosomes. Possible mechanisms for GPI-dependent transport are discussed with respect to current models of vesicular trafficking.

In view of actual situation of serious resources waste and less than 30% of face recovery ratio to shallow seams with existing features of harder roof at the process of room and pillar mining in northern Shaanxi province in China, reasonable support strength has been studied in both cases of normal mining and force caving for improved longwall mechanized mining face, and obtained reasonable working support resistance at the condition of force caving which was better than normal mining. Based on this condition, Shandong Xin Mei machinery Co, Ltd. has developed hydraulic support with hanging chain and splicing beam which was suitable to existing features of shallow seams. The support had advantages with flexible connection between supports to ensure that all pillars reached rated setting load, sub-size top beam to resolve "protection" and "cutting" dilemma for the roof, adjusting and locking support, etc. The company also has given concrete support parameters. By the field industrial test verification, the developed new support fully adapted strata behavior at the process of force caving with existing features of shallow depth and harder roof. The research has provided a useful reference for other coal mines with similar geological features.

Chromatin remodelers such as the SWI/SNF complex coordinate metazoan development through broad regulation of chromatin accessibility and transcription, ensuring normal cell cycle control and cellular differentiation in a lineage-specific and temporally restricted manner. Mutations in genes encoding the structural subunits of chromatin, such as histone subunits, and chromatin regulating factors are associated with a variety of disease mechanisms including cancer metastasis, in which cancer co-opts cellular invasion programs functioning in healthy cells during development. Here we utilize Caenorhabditis elegans anchor cell (AC) invasion as an in vivo model to identify the suite of chromatin agents and chromatin regulating factors that promote cellular invasiveness. We demonstrate that the SWI/SNF ATP-dependent chromatin remodeling complex is a critical regulator of AC invasion, with pleiotropic effects on both G0 cell cycle arrest and activation of invasive machinery. Using targeted protein degradation and enhanced RNA interference (RNAi) vectors, we show that SWI/SNF contributes to AC invasion in a dose-dependent fashion, with lower levels of activity in the AC corresponding to aberrant cell cycle entry and increased loss of invasion. Our data specifically implicate the SWI/SNF BAF assembly in the regulation of the G0 cell cycle arrest in the AC, whereas the SWI/SNF PBAF assembly promotes AC invasion via cell cycle-independent mechanisms, including attachment to the basement membrane (BM) and activation of the pro-invasive fos-1/FOS gene. Together these findings demonstrate that the SWI/SNF complex is necessary for two essential components of AC invasion: arresting cell cycle progression and remodeling the BM. The work here provides valuable single-cell mechanistic insight into how the SWI/SNF assemblies differentially contribute to cellular invasion and how SWI/SNF subunit-specific disruptions may contribute to tumorigeneses and cancer metastasis.

A subset of guanine-rich nucleic acid sequences has the potential to fold into G-quadruplex (G4) secondary structures, which are functionally important for several biological processes, including genome stability and regulation of gene expression. Putative quadruplex sequences (PQSs) G3+N1–7G3+N1–7G3+N1–7G3+ are widely found in eukaryotic and prokaryotic genomes, but the base composition of the N1-7 loops is biased across species. Since the viruses partially hijack their hosts’ cellular machinery for proliferation, we examined the PQS motif size, loop length, and nucleotide compositions of 7370 viral genome assemblies and compared viral and host PQS motifs. We studied seven viral taxa infecting five distant eukaryotic hosts and created a resource providing a comprehensive view of the viral quadruplex motifs. Overall, short-looped PQSs are predominant and with a similar composition across viral taxonomic groups, albeit subtle trends emerge upon classification by hosts. Specifically, there is a higher frequency of pyrimidine loops in viruses infecting animals irrespective of the viruses’ genome type. This observation is confirmed by an in-depth analysis of the Herpesviridae family of viruses, which showed a distinctive accumulation of thermally stable C-looped quadruplexes in viruses infecting high-order vertebrates. The occurrence of viral C-looped G4s, which carry binding sites for host transcription factors, as well as the high prevalence of viral TTA-looped G4s, which are identical to vertebrate telomeric motifs, provide concrete examples of how PQSs may help viruses impinge upon, and benefit from, host functions. More generally, these observations suggest a co-evolution of virus and host PQSs, thus underscoring the potential functional significance of G4s.

The strategic goal of economic and social policy in the countryside should be to ensure an integrated multifunctional development of communities, which would increase their role not only in the development of agricultural production, but also in other types of labor activities, and also, which is very important, to ensure a favorable environment for their living. Thus, the strategic foundation of this solution is the development of the productive forces of each rural community. Therefore, the orientation of the rural communities, especially the united ones, to its own resources and opportunities is the strategic basis for the revival of the Ukrainian peasantry, and given the amount of unemployed population living in rural areas today, it has a rational content. In this context, state aid could take part in the development of a Comprehensive rural development program and the revival of the peasantry, with regard to possibilities of each community, based on the new economic policy, the basis and strategic base of which should be mass co-operative movement. Due to the association of small rural producers, their contribution to the production of gross agricultural products will be significantly appreciable, so effective assistance to power structures of all levels, especially legal ones, could actually, in a short period of time, affect the increase in the profitability of their management, the creation of acceptable social conditions, improving their social protection, adapting and raising awareness of the latest technological solutions to increase their own production of cheap and quality products, as well as what is extremely important today is the improvement of the well-being of the peasants. A comprehensive, consolidated combination of the concrete efforts of the state and the resources that the rural population still possesses, in the name of its new territorial communities, under certain conditions, could become a major driving force in ensuring the systematic development and revival of the Ukrainian peasantry, which is one of the most important foundations of its existence. The modern village really needs development, and this development – financial, organizational, systemic and other forms of support. That is, there is a need for a coherent and systemic village development policy, or, as they call it European researchers, rural development policy, in our today's sense, as well as united territorial communities. Against the backdrop of a sharp rise in energy prices, agricultural machinery, fertilizers, feed, services, etc., low purchase prices, the lack of stable and reliable sales channels makes its production extremely ineffective. Solving similar issues in Ukraine is possible only with the state support for the development of agricultural servicing cooperatives as an important factor, increasing the competitiveness of private farms and individuals who are engaged in agricultural production, improving their socio-economic status and expanding their employment. The development of cooperation is a logical stage in the development of a market economy system in agriculture and one of the ways of integrated development of rural united communities. In particular, the success of rural cooperatives in Galicia in the first half of the 20th century showed a high level of adaptability of local economic traditions to European culture of agricultural production and successful agricultural business. This, extremely important for today's conditions, the experience of the survival of the Galician village until 1939, as well as the Ukrainian community abroad, showed that only uniting all the patriotic forces of the Ukrainian community and channeling their efforts to revive a solid, highly organized under the state guardianship and protection of the cooperative movement, will enable in the coming years to ensure sustainable development of rural communities and to solve problems of food security of the state.

This writing presents results of simulating oscillatory and combined steady and oscillatory flows past gravity anchors astride subsea pipelines. It can be considered a companion to a previous numerical study on steady currents past gravity anchors. The gravity anchor system comprises large arch-shaped concrete blocks positioned at intervals astride offshore pipelines, and it is engineered to provide innovative and cost-effective secondary stabilisation for high-capacity gas-transporting pipelines serving in severe metocean conditions, e.g. cyclone-prone offshore areas. A free-settling marine object bottom-seated on the seabed, however, the gravity anchor may subside into scour pits around its base due to locally disturbed flow regimes, imposing integrity risks on the pipe. Also, the effect of gravity anchors on hydrodynamic loading on nearby pipeline lengths is of interest. The present study employed a Petrov-Galerkin finite element method to solve the three-dimensional Navier-Stokes equations in direct numerical simulation. Firstly sinusoidal flow oscillating perpendicularly to the pipe beneath gravity anchors on an immobile bed was simulated at a Keulegan-Carpenter number of 10 and a pipe Reynolds number of 1000. Then, a steady current co-directionally superimposed on the aforementioned oscillatory flow was modelled at a ratio of steady current velocity to oscillatory flow velocity amplitude of 1. With sediment transport capacity related to bed shear stresses, the time-averaged bed shear stress amplification around gravity anchors in oscillatory flow was revealed first, and found to be consistent with laboratory observations of scour patterns. The effect of superimposing steady flow onto oscillatory flow on bed shear stress amplification was then explored. Lastly, hydrodynamic forces on pipelines in the vicinity of gravity anchors were gauged. The present work intends to shed light on the initial seabed responses with regard to the scour process around gravity anchors immersed in the oceanic wave boundary layer, as well as the effect of gravity anchors on hydrodynamic loadings on pipelines.