Дисертації з теми "Alveolar bone regeneration"
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Alssum, Lamees. "Blood Perfusion and Wound Healing Following Alveolar Bone Regeneration Procedures." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1466587477.
Повний текст джерелаSahlin-Platt, Annika. "Bone tissue regeneration indento-alveolar surgery : clinical and experimental studies on biomaterials and bone graft substitutes." Doctoral thesis, Umeå universitet, Institutionen för odontologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-47418.
Повний текст джерелаHariri, Firdaus. "Alveolar distraction osteogenesis for dental implant rehabilitation inreconstructed jaws." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44661514.
Повний текст джерелаZamparini, Fausto <1988>. "Peri-Implant And Periapical Oral Bone Defects: Clinical Strategies To Achieve Alveolar Bone Stability And Experimental Bone Regeneration Procedures." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/9102/1/Tesi%20Zamparini%20revised%206.11.19.pdf.
Повний текст джерелаLozano-Carrascal, Naroa. "Topical Application of Bisphosphonates to Enhance Alveolar New Bone Formation." Doctoral thesis, Universitat Internacional de Catalunya, 2017. http://hdl.handle.net/10803/456485.
Повний текст джерелаChambrone, Daniela. "Estudo clínico randomizada, duplo cego, do efeito do tratamento de defeitos infra-ósseos com a proteína da matriz do esmalte.Resultados após dois anos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/23/23146/tde-11042008-113921/.
Повний текст джерелаThe aim of the present clinical trial was to compare the periodontal clinical parameters after the treatment of intrabony defects with open flap debridement (OFD) with or without enamel matrix derivative (EMD). Ten subjects with good health, chronic periodontite and one or more pair of the intrabony defects (PPD >= 6 mm), totalizing 38 defects. All the patients received instructions of buccal hygiene, scaling and root planning, previous surgery. They were divided into two groups: group PME received open flap debridement associated to the enamel matrix protein; and the group OFD just received open flap debridement. All the patients passed by control sessions and buccal maintenance every 3 months, until the experiment end. After 24 months, a mean reduction of PPD was 4,21 mm (EMD) and 3,28 mm (OFD), beginning at the end of the experiment, significant result for both groups (p < 0,001), however, EMD showed PPD reduction statistically superior to OFD, at 24 months (p = 0,030). For the relative attachment level (RAL) the mean gain was 5,69 mm (EMD) and 5,24 mm (OFD), being these significant for both groups (p < 0,001) compared the beginning at the end of the experiment, however, there was not significant difference when compared to the means between both groups, at the end of the work (p = 0,59). With regard to PI, it was detected a significant reduction in the two groups along the treatment (p=0,022 to EMD; P=0,005 to OFD), 60% to the group EMD and 80% to the group OFD, without however a statistically significant difference between groups be observed (p=0,46). When observed GI, so much in the EMD as in OFP, it was detected a significant reduction along the experiment (p<0,001), however, there was not significant difference between groups in no experiment moment (p=0,34). RG was larger for EMD than for OFP (p<0,001), for EMD increased 1,02 mm, although of this result, the mean values of GR were not different statistically when compared between groups (p=0,68). There was not significant alteration in the keratinized tissue quantity in EMD (p = 0,23), while in the OFD there was a significant reduction in the keratinized tissue band along time of 0,78 mm (p=0,010), without differentiating significant statistics between groups. The dental mobility did not suffer changes along time in both group (p=0,90). In conclusion, the intra-bony periodontal defects treatment through the enamel matrix protein association with the open flap debridement results in more reduction to the probing clinical depth when compared to the open flap debridement, after 24 months.
Ramirez, German Omar. "The role of prostaglandin E₂ on the alveolar bone turnover in the rat mandible /." [St. Lucia, Qld.], 2006. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19132.pdf.
Повний текст джерелаColli, Vilma Clemi [UNESP]. "Análise da ação da ocitocina sobre a remodelação óssea alveolar em ratas wistar de 12, 18 e 24 meses." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/100955.
Повний текст джерелаA ação da ocitocina (OT) como regulador direto da massa óssea foi reportada em roedores jovens e este efeito anabólico foi atribuído à ação periférica deste hormônio. O objetivo deste estudo foi investigar a ação periférica de OT no processo de reparo alveolar de ratas Wistar de 12, 18 e 24 meses. Ratas de 12 meses com ciclo estral normal e ratas de 18 e 24 meses em diestro permanente receberam duas injeções intra-peritoniais (12 horas de intervalo) de salina (NaCl 0,15M – grupos controle) ou OT (134g/Kg – grupos tratados). Sete dias após, o incisivo direito foi extraído e as análises foram realizadas com 28 dias de reparo alveolar (35 dias após administração de salina ou OT). Os resultados plasmáticos de cálcio e fósforo não diferiram entre os grupos. Os marcadores bioquímicos sistêmicos de formação óssea, fosfatase alcalina (FAL) e osteocalcina (OC), não revelaram diferença significativa de valores na comparação entre grupos controle e tratado de 12 meses, porém esta diferença foi significativa para os dois marcadores quando os animais tratados de 18 e 24 meses foram comparados com os respectivos controles. A análise histomorfométrica e a reação de imunohistoquímica contra OC confirmaram estes resultados mostrando que o tratamento com OT, promoveu maior formação óssea nos animais de 18 e 24 meses. O marcador sistêmico de reabsorção óssea, fosfatase ácida resistente ao tartarato (TRAP) não foi estatisticamente diferente entre animais dos grupos controle e tratado de 12 e 18 meses, porém nos de 24 meses este valor foi significativamente menor nos animais tratados indicando diminuição de reabsorção por ação de OT nos animais desta idade. A imunomarcação para TRAP realizada nos cortes alveolares confirmou os...
The action of oxytocin (OT) as a direct regulator of bone mass has been reported in young rodents and this anabolic effect was attributed to the peripheral action of this hormone. The aim of this study was to investigate the peripheral action of OT in the process of alveolar repair of Wistar rats with 12, 18 and 24 months. Rats of 12 months with normal estrous cycle and rats with 18 and 24 months in permanent diestrus received two intra-peritoneal injections (12 hours apart) of saline (NaCl 0.15 M - control group) or OT (134 g / kg - treated groups). Seven days later, the right incisor was extracted and the analyzes were performed with 28 days of alveolar repair (35 days after administration of saline or OT). The plasma results of calcium and phosphorus did not differ between groups. The systemic biochemical bone formation markers, alkaline phosphatase (ALP) and osteocalcin (OC), revealed no significant difference of values in animals of 12 months, but this difference was significant for both markers when treated animals of 18 and 24 months were compared to controls. The histomorphometric analysis and immunohistochemical reaction against osteocalcin confirmed these results showing that treatment with OT, promoted greater bone formation in animals with 18 and 24 months. The systemic marker of bone resorption, tartrate-resistant acid phosphatase (TRAP) was not statistically different between animals of the control and treated groups of 12 and 18 months, but in 24 months the values were significantly lower in treated animals indicating decreased resorption action of OT in animals of this age. The immunostaining for TRAP performed on alveolar cuts confirmed the results of the results of systemic markers in groups of 12 and 24 months... (Complete abstract click electronic access below)
Colli, Vilma Clemi. "Análise da ação da ocitocina sobre a remodelação óssea alveolar em ratas wistar de 12, 18 e 24 meses /." Araçatuba, 2012. http://hdl.handle.net/11449/100955.
Повний текст джерелаCoorientador: Poli Mara Spritzer
Banca: João Cesar Bedran de Castro
Banca: Roberta Okamoto
Banca: Keico Okino Nonaka
Banca: Marcelo Alves da Silva Mori
Resumo: A ação da ocitocina (OT) como regulador direto da massa óssea foi reportada em roedores jovens e este efeito anabólico foi atribuído à ação periférica deste hormônio. O objetivo deste estudo foi investigar a ação periférica de OT no processo de reparo alveolar de ratas Wistar de 12, 18 e 24 meses. Ratas de 12 meses com ciclo estral normal e ratas de 18 e 24 meses em diestro permanente receberam duas injeções intra-peritoniais (12 horas de intervalo) de salina (NaCl 0,15M - grupos controle) ou OT (134g/Kg - grupos tratados). Sete dias após, o incisivo direito foi extraído e as análises foram realizadas com 28 dias de reparo alveolar (35 dias após administração de salina ou OT). Os resultados plasmáticos de cálcio e fósforo não diferiram entre os grupos. Os marcadores bioquímicos sistêmicos de formação óssea, fosfatase alcalina (FAL) e osteocalcina (OC), não revelaram diferença significativa de valores na comparação entre grupos controle e tratado de 12 meses, porém esta diferença foi significativa para os dois marcadores quando os animais tratados de 18 e 24 meses foram comparados com os respectivos controles. A análise histomorfométrica e a reação de imunohistoquímica contra OC confirmaram estes resultados mostrando que o tratamento com OT, promoveu maior formação óssea nos animais de 18 e 24 meses. O marcador sistêmico de reabsorção óssea, fosfatase ácida resistente ao tartarato (TRAP) não foi estatisticamente diferente entre animais dos grupos controle e tratado de 12 e 18 meses, porém nos de 24 meses este valor foi significativamente menor nos animais tratados indicando diminuição de reabsorção por ação de OT nos animais desta idade. A imunomarcação para TRAP realizada nos cortes alveolares confirmou os... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The action of oxytocin (OT) as a direct regulator of bone mass has been reported in young rodents and this anabolic effect was attributed to the peripheral action of this hormone. The aim of this study was to investigate the peripheral action of OT in the process of alveolar repair of Wistar rats with 12, 18 and 24 months. Rats of 12 months with normal estrous cycle and rats with 18 and 24 months in permanent diestrus received two intra-peritoneal injections (12 hours apart) of saline (NaCl 0.15 M - control group) or OT (134 g / kg - treated groups). Seven days later, the right incisor was extracted and the analyzes were performed with 28 days of alveolar repair (35 days after administration of saline or OT). The plasma results of calcium and phosphorus did not differ between groups. The systemic biochemical bone formation markers, alkaline phosphatase (ALP) and osteocalcin (OC), revealed no significant difference of values in animals of 12 months, but this difference was significant for both markers when treated animals of 18 and 24 months were compared to controls. The histomorphometric analysis and immunohistochemical reaction against osteocalcin confirmed these results showing that treatment with OT, promoted greater bone formation in animals with 18 and 24 months. The systemic marker of bone resorption, tartrate-resistant acid phosphatase (TRAP) was not statistically different between animals of the control and treated groups of 12 and 18 months, but in 24 months the values were significantly lower in treated animals indicating decreased resorption action of OT in animals of this age. The immunostaining for TRAP performed on alveolar cuts confirmed the results of the results of systemic markers in groups of 12 and 24 months... (Complete abstract click electronic access below)
Doutor
Glazier, Thomas F., Thomas C. Waldrop, John C. Gunsolley, and Robert Sabatini. "The Role of Leukocyte-Platelet Rich Fibrin in Human Alveolar Ridge Preservation: A Randomized Clinical Trial." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3735.
Повний текст джерелаPatterson, Jennifer. "Regenerative matrices for oriented bone growth in craniofacial and dental repair /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8018.
Повний текст джерелаToledo, Henrique José Baldo de [UNESP]. "Reparação óssea após osteotomia com brocas de alta e baixa rotação e refrigeração líquida: estudo histológico comparativo entre tecido ósseo alveolar e extra-alveolar em suínos." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/102337.
Повний текст джерелаCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Considerando-se que o processo de reparo ósseo em suínos mostra maior proximidade nos quadros histológicos entre as variáveis estudadas, quando comparado com outros modelos biológicos, teve-se como propósito no presente estudo comparar histologicamente o processo de reparo ósseo em suínos após osteotomias realizadas em osso alveolar e extra-alveolar, empregando-se instrumentos giratórios com refrigeração liquida, de baixa e ultravelocidade. Foram utilizados dezoito suínos da raça Large White com peso corporal entre 20 e 25 Kg, divididos em 3 grupos de seis animais cada, sendo cada grupo constituído por três animais para avaliação do reparo de osteotomias realizadas em osso alveolar e outros três em osso extra-alveolar, nos tempos pós-operatórios de 7, 14 e 28 dias. Foi observado que para o osso alveolar nos tempos pós-operatórios de 14 e 28 dias, os melhores resultados de reparo ósseo ocorreram nas osteotomias realizadas com brocas de baixa velocidade, ao passo que no tempo pós-operatório de sete dias, os resultados do reparo ósseo de osteotomias realizadas com brocas de ultravelocidade foram discretamente melhores, tanto nas áreas alveolares como extra-alveolares. Pela metodologia empregada, não se identificaram diferenças significativas no processo de reparo ósseo alveolar e extra-alveolar nos tempos pós-operatórios estudados
The aim of this study was to compare histologically the process of bony repair in swine after osteotomy accomplished in alveolar and extra-alveolar bone using rotative instruments of drop and ultra speed and liquid refrigeration. Eighteen swine of the race Large White between 20 and 25 Kg were divided in 3 groups of six animals, being each group constituted by three animals for evaluation of the osteotomy repair accomplished in alveolar and other bone three in extra-alveolar bone. The postoperative evaluation happened in the times of 7, 14 and 28 days. It was observed that for the alveolar bone in the final postoperative times, of fourteen and twenty-eight days, the best results of bony repair were observed in osteotomy accomplished with drills of low rotation, while in the postoperative time of seven days, the results of the bony repair of osteotomy accomplished with drills of high rotation they were better. The authors consider that the process of bony repair in swine display larger proximity in the histoloogical pictures among the studied variables, when compared with other biological models. As most of the works told in the literature refers the use of dogs, the authors consider that the present work guarantees your importance in the sense of looking for a closer model of the man, so much in the alveolar as extra-alveolar areas. For the used methodology, they didn't identify significant differences in the process of alveolar and extraalveolar bony repair in the studied postoperative times
Lemke, Matthew Jon. "Polylactic acid (PLA) Membrane as a Sole TreatmentFor Alveolar Ridge Preservation." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1402664234.
Повний текст джерелаToledo, Henrique José Baldo de. "Reparação óssea após osteotomia com brocas de alta e baixa rotação e refrigeração líquida : estudo histológico comparativo entre tecido ósseo alveolar e extra-alveolar em suínos /." Araçatuba : [s.n.], 2011. http://hdl.handle.net/11449/102337.
Повний текст джерелаBanca: Iracy Costa
Banca: Cleverson Luciano Trento
Banca: Gilberto Aparecido Coclete
Banca: Elerson Gaetti Jardim Junior
Resumo: Considerando-se que o processo de reparo ósseo em suínos mostra maior proximidade nos quadros histológicos entre as variáveis estudadas, quando comparado com outros modelos biológicos, teve-se como propósito no presente estudo comparar histologicamente o processo de reparo ósseo em suínos após osteotomias realizadas em osso alveolar e extra-alveolar, empregando-se instrumentos giratórios com refrigeração liquida, de baixa e ultravelocidade. Foram utilizados dezoito suínos da raça Large White com peso corporal entre 20 e 25 Kg, divididos em 3 grupos de seis animais cada, sendo cada grupo constituído por três animais para avaliação do reparo de osteotomias realizadas em osso alveolar e outros três em osso extra-alveolar, nos tempos pós-operatórios de 7, 14 e 28 dias. Foi observado que para o osso alveolar nos tempos pós-operatórios de 14 e 28 dias, os melhores resultados de reparo ósseo ocorreram nas osteotomias realizadas com brocas de baixa velocidade, ao passo que no tempo pós-operatório de sete dias, os resultados do reparo ósseo de osteotomias realizadas com brocas de ultravelocidade foram discretamente melhores, tanto nas áreas alveolares como extra-alveolares. Pela metodologia empregada, não se identificaram diferenças significativas no processo de reparo ósseo alveolar e extra-alveolar nos tempos pós-operatórios estudados
Abstract: The aim of this study was to compare histologically the process of bony repair in swine after osteotomy accomplished in alveolar and extra-alveolar bone using rotative instruments of drop and ultra speed and liquid refrigeration. Eighteen swine of the race Large White between 20 and 25 Kg were divided in 3 groups of six animals, being each group constituted by three animals for evaluation of the osteotomy repair accomplished in alveolar and other bone three in extra-alveolar bone. The postoperative evaluation happened in the times of 7, 14 and 28 days. It was observed that for the alveolar bone in the final postoperative times, of fourteen and twenty-eight days, the best results of bony repair were observed in osteotomy accomplished with drills of low rotation, while in the postoperative time of seven days, the results of the bony repair of osteotomy accomplished with drills of high rotation they were better. The authors consider that the process of bony repair in swine display larger proximity in the histoloogical pictures among the studied variables, when compared with other biological models. As most of the works told in the literature refers the use of dogs, the authors consider that the present work guarantees your importance in the sense of looking for a closer model of the man, so much in the alveolar as extra-alveolar areas. For the used methodology, they didn't identify significant differences in the process of alveolar and extraalveolar bony repair in the studied postoperative times
Doutor
Souza, Camila Furtado de. "Preservação alveolar com pôntico ovóide provisório: um estudo clínico-tomográfico controlado e randomizado." Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/5911.
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A remodelação tecidual ocorre em todos os alvéolos dentais após a extração do elemento dentário, comprometendo a reabilitação funcional e estética do paciente. O objetivo do presente estudo foi avaliar as alterações dimensionais alveolares ocorridas com a técnica da preservação alveolar com pôntico ovóide provisório, comparando-a com outras duas técnicas já estabelecidas. Trinta pacientes foram selecionados e divididos em três grupos de acordo com a técnica de preservação alveolar utilizada: Grupo 1: fechamento com deslize de retalho palatino; Grupo 2: associação de substituto ósseo sintético de fosfato de cálcio bifásico e fechamento com deslize de retalho palatino; e Grupo 3: vedamento das margens do alvéolo com pôntico ovóide provisório. Modelos de gesso e exames de tomografia computadorizada de feixe cônico (TCFC) realizados antes das cirurgias e no pós-operatório imediato respectivamente, e repetidos após quatro meses, foram utilizados para comparar a remodelação alveolar. Os resultados encontrados demonstraram que houve remodelação óssea horizontal em todos os grupos com resultados semelhantes entre as três técnicas. Entretanto, todas as técnicas avaliadas foram capazes de manter as dimensões verticais do rebordo alveolar durante o período de quatro meses sem diferença estatisticamente significativa entre elas. Conclui-se que a técnica proposta do pôntico ovóide provisório é eficaz na preservação alveolar, visto que apresentou resultados semelhantes a técnicas já estabelecidas, além de gerar menor morbidade, menor custo e ser facilmente reproduzível.
Tissue remodeling occurs in sockets after tooth extraction, compromising the functional and aesthetic rehabilitation of the patient. The aim of this study was to evaluate the efficacy of the sealing technique with provisional pontic ovoid for ridge preservation compared with two other standard techniques. Thirty patients were selected and divided into three groups according to the used ridge preservation technique: Group 1: closure with palatal pedicle flap; Group 2: association of synthetic bone substitute and closure with palatal pedicle flap; Group 3: sealing the margins of the socket with a provisional ovoid pontic. Plaster casts and cone-beam computed tomography (CBCT) exams performed before the surgeries and at immediate postoperatively, respectively, and repeated after four months, were used to compare socket remodeling. The results demonstrated horizontal bone remodeling in all groups with similar results noted among all groups. However, the three techniques were able to maintain the vertical dimensions of the ridge over the four-month period without significant statistical diferences among them. It is concluded that the proposed technique involving provisional ovoid pontic is effective in ridge preservation, once it presented similar results to previously established techniques, besides generating lower morbidity, lower cost and being easily reproducible.
Llanos, Alexandre Hugo. "Comparação das alterações dimensionais do rebordo alveolar pós-exodontia entre a técnica de preservação alveolar com a utilização de substituto ósseo xenógeno e a cicatrização espontânea: ensaio clínico aleatório." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/23/23146/tde-04042018-112542/.
Повний текст джерелаThe healing process of post-extraction sockets is bone resorption. After tooth extraction, spontaneous healing will lead to loss of volume and shape of the original ridge. Alveolar ridge preservation involves any procedure that limits the effects of post-extraction resorption. The objective of this study was to evaluate the use of the xenogenic bone substitute in the post-extraction alveolar preservation compared to spontaneous healing in anterior maxilla teeth with vestibular wall defects greater than 50%. Thirteen patients with anterior maxillary tooth extraction with a > 50% buccal wall loss were treated. All the surgeries were made flapless. Patients were randomly assigned to a test group: alveolar preservation with bone substitute (7 participants); and control group: spontaneous healing (6 participants). The primary outcome was the dimensional alteration of the alveolar ridge calculated between the tomographic images at the beginning (post-extraction) and after 4 months of the intervention, at the thickness 1mm below the coronal portion of the crest (HW-1). Secondary outcomes were measures buccal and palatine, and HW-3 and HW-5 cross-sections. The HW-1 measure reduced 51.21% in the test group and 82.80% in the control group, with a statistically significant intergroup difference of 31.59%. For the other horizontal measurements, there was a statistically significant reduction for both HW-3 and HW-5 between the two groups. In sockets with buccal wall loss greater than 50%, the use of the bone substitute provided a 30% lower horizontal loss.
Gutta, Rajesh. "Barrier membranes for ridge augmentation is there an optimal pore size? /." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. http://www.mhsl.uab.edu/dt/2007m/gutta.pdf.
Повний текст джерелаDias, Sheila Mônica Damásio. "Ação do estrógeno na expressão de proteínas relacionadas ao metabolismo ósseo durante regeneração alveolar em ratas /." Araçatuba : [s.n.], 2007. http://hdl.handle.net/11449/93593.
Повний текст джерелаAbstract: Objective: To evaluate the role of E2 during alveolar bone regeneration, using OPG, RANK and RANKL protein expression as cellular indicators of predisposition to resorption or bone tissue formation. Methods: Eight days after either SHAM surgery or ovariectomy (OVX), the OVX rats (200g) received subcutaneous implants with corn oil (OVX/oil group) or E2 (400μg) (OVX/E2 group). Extraction of the maxillary right incisors were performed during the course of the treatment and was scheduled in such a way that at the end of a 60-day period it would possible to retrieve anatomic pieces referring to 14, 28 and 42 days of alveolar bone healing. The pieces were submitted to immunohistochemical processing. Results: In the animals with regular estrous cycle (SHAM group), it was observed low expression at 14 days, medium/high expression at 28 days and no OPG and RANKL expression at 42 days. RANK expression started high and decreased continuously up to the last analyzed period. In the OVX/oil group, RANKL expression increased up to the completion of the analysis at 42 days, whereas RANK expression decreased within the studied period. OPG expression was observed in the beginning and the end of the analyzed period. The animals OVX/E2 showed similar labeling for OPG, RANK and RANKL at 14 days. RANKL expression was observed up to the end of the experiment. However, no OPG and RANK expression was detected at 28 and 42 days. Conclusion: These results demonstrate the role of E2 modulating the alveolar bone remodeling cycle.
Orientador: Idelmo Rangel Garcia Júnior
Coorientador: Rita Cássia Menegati Dornelles
Banca: Ana Maria Pires Soubhia
Banca: Teresa Lucia Lamano Carvalho
Mestre
Vieira, Andreia Espíndola. "Caracterização morfométrica e molecular do papel de citocinas pró e anti-inflamatórias no processo de reparo ósseo alveolar em condições homeostáticas e infecciosas." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/25/25149/tde-22112013-113101/.
Повний текст джерелаBone metabolism is influenced by endocrine, genetic and growth factors, RANK/RANKL/OPG system, besides a variety of regulatory molecules, such as cytokines. Cytokines have been implicated in pathogenesis of bone diseases, however, little is known about the mechanisms involved in the interaction between skeletal and immune system in the bone repair process. The objective of this study was characterized the role of TNF-α and IL-10 in alveolar bone repair under homeostatic (control [C]) and infectious (experimental alveolitis [A]) conditions in C57Bl/6 (WT), TNFp55KO and IL-10KO mice. After surgery, in infectious groups was induced by ischemia alveolitis the well and a suspension of pus. The maxillas were collected at 0h, 7, 14 and 21 days after extraction of the maxillary incisor for histologic, histomorphometric and molecular (RealTimePCR). In histomorphometric analysis parameters were measured clot, inflammatory cells, fibers, fibroblasts, blood vessels, bone matrix, osteoblast, osteoclast, and other space - the interstitial fluid and bone mar row. Molecular analysis (RealTimePCR) were quantified the expression of growth factors, bone markers and extracellular matrix, cytokines and chemokines involved in the process. The data were submitted to the OneWay ANOVA test followed by Tukey\'s multiple comparison test. The results showed that in WT-C initial clot formation (0 hours) with early expression of BMP2, BMP4, BMP7, and TGFb1 VEGFa who had gradual increase peaking in 7 days. The expression of TNF-α and IL10 also peaked at 7 days in parallel with leukocyte count, associated with CCL2, CCL5 and CXCL1. In late periods there were decrease of inflammation and markers osteoblastic / osteogenic increased. Induction of experimental alveolitis in WT resulted in a marked increase in expression of TNF-α accompanied by increased expression of CXCL1 and CCL5, increased leukocyte count and decreased of IL10 expression that peaked at 14d, besides prominent leukocyte infiltration and granulation tissue, as well as histological evidence of delayed bone repair. Negative impact of alveolitis was attenuated in TNFp55KO mice, characterized by appropriate repair rate, decreased of the number of leukocytes and osteoclasts that WT-A. On the other hand, a lessened repair was observed in IL10KO animals, evidenced by lower density of the density of osteoblasts and bone matrix than respective control. In conclusion, the results show that both cytokines interferes in alveolar bone repair through mechanisms that involve the control of inflammatory cell migration and modulation of chemokines and osteogenic markers expression, since that the absence of IL-10 is associated with higher inflammatory activity and bone resorption concomitant with lower bone formation, while the deficiency of TNF-αa affect the recruitment of leukocytes and the kinetics of alveolar bone healing both in homeostatic and infectious conditions.
Asa'Ad, F. "ALVEOLAR BONE AUGMENTATION PRIOR TO DENTAL IMPLANT PLACEMENT: VOLUME ANALYSIS & APPLICATIONS OF PRE-AUGMENTATION SOFT TISSUE EXPANSION (STE) AND REGENERATION WITH 3D PRINTED SCAFFOLDS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/534216.
Повний текст джерела1.1. ABSTRACT OBJECTIVES: The aim of this review was to explore the development of soft tissue expanders, their different types and their potential applications prior to bone augmentation and implant placement. MATERIALS & METHODS: A review of pertinent literature was performed using PubMed to comprehend the dynamics of soft tissue expanders and determine the current position of their pre- augmentation applications. RESULTS: There is promising, albeit preliminary information regarding the benefits of pre- augmentation soft tissue expansion (STE). Findings cannot be generalized due to relatively small sample size of the scarce clinical studies available in literature. CONCLUSIONS: Further clinical trials with larger sample sizes and long-term follow-up are needed before soft tissue expanders can be confidently applied in everyday clinical practice. 2.1. ABSTRACT OBJECTIVES: To investigate the clinical outcomes, complications and volume gain of pre-augmentation soft tissue expansion (STE). MATERIALS & METHODS: Tissue expanders were implanted in seven patients requiring vertical and/or horizontal bone augmentation. Guided bone regeneration (GBR) was carried out either after 20, 40 or 60 days of STE. Vertical and horizontal bone gains were analyzed with cone beam computed tomography (CBCT) scans. Optic scanning and superimposition of cast models fabricated from pre- and post- augmentation alginate impressions were used for volumetric analysis. RESULTS: Seven sites in seven patients were treated with STE. Perforation occurred in two sites; early failure due to the tightness of the prepared pouch, and late failure due to minor cracks of the silicon shell covering the expander as a result of handling of the expander body with a dental tweezer. Post-expansion, primary wound closure was easily achieved at augmentation without any subsequent graft expositions. Six months post-augmentation, CBCT analysis revealed high vertical bone gain (mean = 7.3 ± 1.2 mm). Mean of horizontal bone gain was 5.5 ± 2.9 mm. Volumetric analysis of three successful expansion cases revealed a mean volume increase of 483.8 ± 251.7 mm3. Soft tissue volume increase corresponded only to the 0.24 ml cylinder expander (volume increase = 259.4 mm3), while this increase was almost half of the final expander volume for the 0.7 and 1.3 ml cylinder expanders (436.1 mm3 & 755.9 mm3 respectively). Volumetric analysis of the late expansion failure reflected soft tissue shrinkage, which might suggest that STE affects tissues by tension and does not cause real volume gain. All dental implants were osseointegrated in the patients that underwent subsequent dental implant therapy. CONCLUSIONS: High vertical bone gain and minimal post-surgical complications were associated with bone augmentation procedures preceded by soft tissue expansion (STE). 3.1. ABSTRACT To ensure a successful dental implant therapy, presence of adequate vertical and horizontal alveolar bone is fundamental. However, an insufficient amount of alveolar ridge in both dimensions is often encountered in dental practice due to the consequences of oral diseases and tooth loss. Although post-extraction socket preservation has been adopted to lessen the need for such invasive approaches, it utilizes bone-grafting materials, which have limitations that could negatively affect the quality of bone formation. To overcome the drawbacks of routinely employed grafting materials, bone-graft substitutes such as 3D-scaffolds have been recently investigated in the dental field. In this review, we highlight different biomaterials suitable for 3D-scaffold fabrication, with a focus on “3D-printed” ones as bone graft substitutes that might be convenient for various applications related to implant therapy. We also briefly discuss their possible adoption for periodontal regeneration. 4.1. ABSTRACT OBJECTIVES: To analyze bone resorption patterns in the posterior mandibles and their corresponding digitally designed bone grafts to understand if they come in distinct clusters. MATERIALS & METHODS: In this retrospective analysis, 120 CBCT scans were analyzed to evaluate the frequency of Cawood & Howell classification, in right and left posterior mandibles. Results were compared between gender and age. The most frequent atrophic class that needs bone augmentation was virtually regenerated in the mandibular segments using specific software. Height, width and length of the obtained grafts were analyzed to conclude if these grafts come in distinct clusters. RESULTS: Class V was the most frequent atrophic class in comparison to class IV & VI in the left and right posterior mandibles (16%, 20.8% respectively). Severe atrophic stages were more frequent in females (p= 0.029 for the left side, p= 0.007 for the right side) and in older age groups (p= 0.008 for the right side) After virtual regeneration of class V defects, three clusters were evident, differing only in length, based on the number of missing teeth (p= 0.0001). Height and width of the virtual grafts were comparable for the three clusters (p > 0.05). Mean virtual graft volume was 2,184 mm3 (four missing teeth), 1,819 mm3 (three missing teeth) & 1,476 mm3 (two missing teeth). CONCLUSIONS: Stage V atrophy was the most frequent resorption pattern in comparison to classes IV & V, in posterior mandibles. Virtual regeneration procedure revealed three clusters of virtual grafts, differing only in the length based on the number of missing teeth. Future studies are recommended to determine the adaptation ratio between virtual and actual grafts to bone surface.
Romão, Marcia Maria Altavista. "Efeito da laserfototerapia na reparação de osso alveolar humano: análise microtomográfica e histomorfométrica." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-16042015-102045/.
Повний текст джерелаThe immediate dental implant placement in the molars region is critical, because of the high amount of bone loss and the discrepancy between the alveolar crest thickness and the dental implant platform. Laserphototherapy (LPT) improves bone repair thus could accelerate the implant placement. Twenty patients were selected for the study. Ten patients were submitted to LPT with GaAlAs diode laser (808nm) during molar extraction, immediately after, 24h, 48h, 72h, 96h, 7 and 15 days. The irradiations were applied in continuous wave, in contact and punctual mode (100mW, 0.04cm2, 075,0J/cm2, 30s per point, 3J per point, in 5 points). The control group (n=10) received the same treatment; however with the power of the laser off. Forty days later samples of the tissue formed inside the sockets were obtained for further microtomography (microCT) and histomorphometry analyses. Data of both groups were compared by the Student t test, whereas those from the different microCT parameters were compared by the Pearson correlation test (p<0.05). The relative bone volume, as well as the relative area were significantly higher (p<0.001) in the lased than the control group. In the control group there were negative correlations between number and thickness, and between number and separation of trabecula (p<0.01); between thickness and separation of trabecula the correlation was positive (p<0.01). The laser group showed significant negative correlation between the number and the thickness of trabecula (p<0.01). Laserphototherapy accelerated bone repair. By the Pearson correlation test it was possible to infer that the lased group presented a more homogeneous trabecula configuration, with thin and numerous trabecula, which would facilite the reduction of time for the installation of the implant.
Melo, Alexandre de. "Estudo da reparação do alvéolo dental de ratos wistar preenchido com osso autógeno particulado após exodontia." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-03012008-151813/.
Повний текст джерелаAfter tooth extraction a continuous bone resorption of the alveolar process is observed in the maxilla and in the mandible. The unfavorable anatomy of the reabsorbed bone ridge limits the rehabilitation of the edentulous area with prostheses over dental implants. Filling the dental alveolus after the exodontia with bone grafts and/or biomaterials is a procedure that tries to delay the physiologic resorption of the alveolar process and stimulates bone formation. The aim of this study is to investigate the influence of the particulated autogenous bone graft in the alveolar socket healing following tooth extraction in Rattus Norvegicus Albinus lineage Wistar. Sixty-seven male rats were used, each weighing 190 to 250 g. The animals were divided in a control and an experimental group. The upper right incisor was extracted in the rats of both groups. Following the tooth extraction, in the animals of the experimental group, the socket was grafted with particulated autogenous bone. The bone graft was obtained from the iliac bone of the same grafted animal. At 7, 14 and 21 days of postoperative, some rats received subcutaneous applications of the ossification marker calcein dissolved in a sodium bicarbonate 2% solution. The euthanasia of the animals was accomplished in the 5th, 15th, 21st and 28th days of postoperative. After the euthanasia the bone parts that contain the dental socket of each right maxilla were removed and reduced to small samples. All the samples were then fixed and processed for histological analysis. The total area of bone was quantified in the socket by a differential point-counting method and by use of an image analyzing program. The data were analyzed statistically and showed that there was a progressive increase of the bone total area during the postoperative periods. However, the morphometric analysis of the total area of bone in the control and experimental groups, did not show a significant statistical difference in none of the postoperative periods. The results reveal that the autogenous bone graft did not promote a significant increase of the bone new formation in the dental socket following tooth extraction.
Dias, Sheila Mônica Damásio [UNESP]. "Ação do estrógeno na expressão de proteínas relacionadas ao metabolismo ósseo durante regeneração alveolar em ratas." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/93593.
Повний текст джерелаObjetivo:Avaliar a atuação do E2 durante a regeneração alveolar, utilizando a expressão das proteínas OPG, RANK e RANKL como indicadores celulares de predisposição à reabsorção ou formação de tecido ósseo. Material e métodos: Após 8 dias da cirurgia SHAM ou ovariectomia (OVX), as ratas (200g) OVX receberam implantes subcutâneos contendo óleo de milho (grupo OVX/óleo) ou E2 (400μg) (grupo OVX/E2). As exodontias dos incisivos superiores direitos foram realizadas no decorrer do tratamento e agendadas para que ao término de 60 dias fosse possível obter as peças referentes a 14, 28 e 42 dias de regeneração óssea alveolar. As peças foram submetidas a processamento imunoistoquímico. Resultados: Nos animais com ciclo estral regular (grupo SHAM), foi observada expressão baixa aos 14, média/alta aos 28 e a não expressão de OPG e RANKL aos 42 dias. A expressão de RANK iniciou alta e foi diminuindo até o último período analisado. No grupo OVX/Óleo a expressão de RANKL foi crescente até o término da análise aos 42 dias, enquanto que a expressão de RANK diminuiu ao longo do período estudado. Foi observada expressão de OPG no início e ao final do período analisado. Os animais OVX/E2 apresentaram marcação semelhante para OPG, RANK e RANKL aos 14 dias. A expressão de RANKL foi observada até o final do experimento, entretanto não foi detectada expressão de OPG e RANK aos 28 e 42 dias. Conclusão: Estes resultados evidenciam a participação do E2 modulando o ciclo de remodelação óssea alveolar.
Objective: To evaluate the role of E2 during alveolar bone regeneration, using OPG, RANK and RANKL protein expression as cellular indicators of predisposition to resorption or bone tissue formation. Methods: Eight days after either SHAM surgery or ovariectomy (OVX), the OVX rats (200g) received subcutaneous implants with corn oil (OVX/oil group) or E2 (400μg) (OVX/E2 group). Extraction of the maxillary right incisors were performed during the course of the treatment and was scheduled in such a way that at the end of a 60-day period it would possible to retrieve anatomic pieces referring to 14, 28 and 42 days of alveolar bone healing. The pieces were submitted to immunohistochemical processing. Results: In the animals with regular estrous cycle (SHAM group), it was observed low expression at 14 days, medium/high expression at 28 days and no OPG and RANKL expression at 42 days. RANK expression started high and decreased continuously up to the last analyzed period. In the OVX/oil group, RANKL expression increased up to the completion of the analysis at 42 days, whereas RANK expression decreased within the studied period. OPG expression was observed in the beginning and the end of the analyzed period. The animals OVX/E2 showed similar labeling for OPG, RANK and RANKL at 14 days. RANKL expression was observed up to the end of the experiment. However, no OPG and RANK expression was detected at 28 and 42 days. Conclusion: These results demonstrate the role of E2 modulating the alveolar bone remodeling cycle.
TOMMASATO, GRAZIA. "THE REGENERATION OF EDENTULOUS ATROPHIC RIDGES: PROS, CONS, AND EFFECTIVENESS OF THREE DIFFERENT SURGICAL OPTIONS." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/804105.
Повний текст джерелаFontes, Erica Batista. "Hidroxiapatita sintética associada ou não à fração total de células mononucleares na regeneração de osso alveolar de cães." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/10040.
Повний текст джерелаVários fatores, dentre eles a doença periodontal, podem levar à reabsorção do osso alveolar. O presente trabalho teve como objetivo avaliar a fração total de células mononucleares (FTCM) proveniente da medula óssea (MO) na regeneração alveolar da mandíbula de cães, quando associadas à hidroxiapatita sintética (HA). Para isso, foram utilizados 18 cães divididos em 2 grupos (GI e GII). No GI o defeito foi preenchido somente com o biomaterial. O GII foi tratado com HA associado à FTCM. Defeitos de 4,3 mm de diâmetro foram criados entre as raízes do quarto pré-molar direito no osso alveolar. Esses foram preenchidos com o implante correspondente a cada grupo. A MO foi coletada dos quatro membros do animal. O acesso para a coleta no membro pélvico foi o trocanter maior do fêmur, já o acesso no membro torácico consistiu no côndilo maior do úmero. Da MO coletada, foi extraída a camada mononuclear por meio de centrifugação em gradiente de Histopaque® 1.077. As células mononucleares foram transplantadas logo após separação. Com a finalidade de investigar e comparar a eficiência da regeneração óssea foi realizado avaliações clínicas diárias durante uma semana; avaliações radiográficas no pós-operatório imediato, aos 14, 45 e 60 dias; e exames histológicos aos 14, 45 e 60 dias. A cicatrização da ferida ocorreu de forma satisfatória e semelhante para ambos os grupos. O exame radiográfico revelou evolução semelhante para os dois grupos. No pós-operatório imediato, esse exame, permitiu avaliar o adequado preenchimento do defeito no GI e GII. Nos dois grupos, aos 14 dias, observou-se uma diminuição da radiopacidade,em relação ao pós-operatório imediato, seguida por um aumento na mesma aos 45 dias em relação aos 14 dias. Essa evolução é esperada em um processo de reparação ósseo onde é usado como a HA. A radiopacidade aos 60 dias foi superior daquela observada aos 45 dias, mas o defeito ainda era perceptível. Os exames histológicos indicaram um processo de formação ósseo progressivo nos dois grupos. Aos 14 dias, havia presença de trabéculas ósseas no GII, não sendo observadas no GI nessa data. De fato, o GII apresentou um processo de regeneração óssea mais acelerada em relação ao GI até os 45 dias, sendo comprovado estatisticamente pela presença em maior quantidade de matriz óssea no GII aos 45 dias, ao nível de significância de 5%. Ainda era perceptível a presença da HA em algumas amostras aos 60 dias indicando que essa não foi completamente reabsorvida. Nenhuma reação do tipo corpo estranho foi observada, portanto, comprovando a biocompatibilidade do material. Coletivamente, os resultados obtidos neste trabalho mostraram que a associação da FTCM provenientes da medula óssea de cães à HA favoreceu a regeneração óssea em defeitos realizados no osso alveolar da mandíbula de cães. Quando comparada ao uso somente da hidroxiapatita sintética, esse processo de regeneração ocorreu de forma mais rápida em defeitos preenchidos com o biomaterial associado à FTCM.
Rosa, Jucely Aparecida da [UNESP]. "Estudo da reparação óssea em fêmures de ratas sob a ação local do residronato de sódio." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/95865.
Повний текст джерелаCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Esta pesquisa avaliou o efeito do uso local do residronato de sódio, em diferentes concentrações molares, no processo de reparação de defeitos ósseos em fêmures de ratas. Foi confeccionado no fêmur de 60 ratas um defeito ósseo medindo 2,5 mm de diâmetro. Estes animais foram divididos em grupos: controle (C), amido (Am), residronato 0,25 mol (Res 0,25), residronato 0,5 mol (Res 0,50), residronato 0,75 mol (Res 0,75) e residronato 1 mol (Res 1), de acordo com o material de preenchimento utilizado. Nos animais do grupo controle o defeito ficou preenchido apenas pelo coágulo. Os animais foram eutanasiados aos sete e 21 dias, e o fêmur foi removido, fixado e descalcificado, para a confecção de lâminas histológicas. Foram realizadas análises histológica e histomorfométrica, e os dados obtidos foram submetidos à análise estatística ANOVA. Histologicamente, as principais diferenças ocorreram após 21 dias. Os grupos C e Am apresentaram fechamento em extensão do defeito ósseo em todos os espécimes e a maioria dos animais dos grupos tratados com residronato em diferentes concentrações molares não exibiu neoformação óssea na região central do defeito, permanecendo este preenchido por tecido conjuntivo. Nos períodos de sete e 21 dias não houve diferença estatística significante entre os grupos C e Am em relação a neoformação óssea. Estatisticamente, não houve diferença entre os grupos Res 0,25; Res 0,50; Res 0,75 e Res 1 no período de sete dias. Já no período de 21 dias o grupo Res 0,25 apresentou a maior média, mas não diferiu estatisticamente do grupo Res 0,75. Concluiu-se que o residronato de sódio em todas as concentrações molares, prejudicou a reparação óssea nesse modelo experimental. No entanto, foi observada uma neoformação óssea extra-cortical subperiosteal nos grupos que receberam residronato.
This work evaluated the action of sodium residronate, in different molars concentrations, in the repair of bone defects in femurs of rats. A bone defect measuring 2,5 mm in diameter was made in the femur of 60 rats. These animals were divided in groups: control (C), starch (Am), residronate 0,25 mol (Res 0,25), residronate 0,50 mol (Res 0,50), residronate 0,75 mol (Res 0,75), residronate 1 mol (Res 1), in accordance with the material of fill used. In the animals of the control group, the defect was just filled by the clot originating from the defect. The animals were euthanized at seven and 21 days, when the femur was removed, fixed and decalcified, to make histologicals laminae. Histological and histomorphometric analyses were performed and the results obtained were submitted to statistical analysis ANOVA. Histologically, the principal differences occurred after 21 days. The groups C and Am, showed an extension closure of bone defect in every specimen and most animals in groups treated with residronate in different molar concentrations did not show bone neoformation in the central region of the bone defects, which remained filled with connective tissue. After seven and 21 days, there was no significant statistical difference among groups C and Am in relation to bone neoformation. Statistically, there were no differences among the groups Res 0,25; Res 0,50; Res 0,75 e Res 1 in the period of seven days. In the period of 21 days, the group Res 0,25 had the highest average, but did not differ statistically from the Res 0,75. It was concluded that the sodium residronate in all the molar concentrations, harmed the bone repair in this experimental model. However, there was an extracortical subperiosteal bone neoformation in groups receiving residronate.
Moraes, Júnior Edgard Franco. "Enxerto autógeno para aumento em espessura e ou altura do processo ósseo alveolar, transtornos de técnica cirúrgica, complicações e sobrevivência dos implantes /." Araçatuba, 2002. http://hdl.handle.net/11449/101075.
Повний текст джерелаResumo: Foi realizado um estudo retrospectivo para avaliar os resultados da reconstrução do processo alveolar intensamente reabsorvido com diferentes tipos de enxerto ósseo autógeno associados à instalação de implantes simultâneos e mediatos (após 4 meses da instalação do enxerto) realizados no período de 4 anos e 6 meses. Foram selecionados para este estudo 84 pacientes, submetidos à reconstrução de defeitos ósseos dos maxilares, com enxertos ósseos do mento, linha oblíqua da mandíbula, crista ilíaca anterior e calota craniana, com um total de 346 implantes instalados, sendo que, 257 destes implantes encontravam-se, com as próteses implantossuportadas instaladas, e distribuídos em 40 implantes simultâneos e 217 mediatos. Desta forma, foram avaliadas os transtornos de técnica cirúrgica e as complicações relacionadas com as áreas receptoras, bem como a taxa de sobrevivência dos implantes. De acordo com os resultados obtidos, dentre alguns dos transtornos de técnica cirúrgica e complicações estavam a redução da quantidade de mucosa ceratinizada na cortical vestibular e conseqüente perda da profundidade de sulco, assim como, exposição parcial do enxerto, contaminação do enxerto, entre outras complicações verificadas. A taxa de sobrevivência, obtida para os implantes simultâneos e mediatos instalados, foi de 94,55%. Quando a taxa de sobrevivência foi avaliada individualmente para cada grupo, no caso dos implantes simultâneos foi encontrado um resultado de 97,50%, enquanto que para os implantes mediatos obteve-se um resultado de 94,10%%. Portanto com este estudo, conclui-se que dos transtornos de técnica cirúrgica com maior ocorrência estava a redução da quantidade de mucosa ceratinizada sobre a crista do rebordo, complicações como exposição parcial do enxerto entre outras, que as áreas doadoras intrabucais oferecem vantagem...(Resumo completo, clicar acesso eletrônico abaixo)
Abstract: A retrospective study was carried out in order to evaluate the outcomes of the reconstruction of the severely resorbed alveolar ridge through different types of autogenous bone grafts associated to the placement of simultaneous and delayed implants (4 months after the bone graft procedure) accomplished during a period of 4 years and 6 months. A total of 84 patients were selected for the present study, which were submitted to reconstruction of the bone defects of the jaws by means of bone grafts from the chin, external oblique ridge, anterior iliac crest, cranial vault, adding up to 346 implants, from which 257 (40 simultaneous and 217 delayed implants), with the installed implant-supported prostheses. The evaluation concerned of the overturn of surgical technique and complications related to the receptor sites, as well as the survival rate of the implants. The results indicated occurrence of the overturn of surgical technique and complications such as reduction in the amount of keratinized mucosa over the buccal cortical plate with consequent decrease in vestibular depth, as well as partial exposure of the graft, contamination of the graft, and others. The survival rate for both simultaneous and delayed implants was 94.55%. Regarding the individual evaluation of each group, the simultaneous implants demonstrated a survival rate of 97.50% in relation to 94.10% for the delayed implants. The most frequent of the overturn of surgical technique were reduction in the amount of keratinized mucosa over the alveolar ridge, complications as partial exhibition of the graft among others, better performance of the intraoral donor sites in relation to the extraoral sites, positive association between implant failures and iliac crest grafts, besides significantly worse outcomes for the female subjects in relation to the males. Better results were observed for the simultaneous implants, what is in disagreement with previous studies.
Doutor
POLI, PIER PAOLO. "COMPUTER-GUIDED IMPLANT PLACEMENT ASSOCIATED WITH COMPUTER-AIDED BONE REGENERATION IN THE TREATMENT OF ATROPHIED PARTIALLY EDENTULOUS ALVEOLAR RIDGES: A PROSPECTIVE PROOF-OF-CONCEPT STUDY." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/604498.
Повний текст джерелаSantos, Felipe Anderson Sousa dos. "Avaliação do uso de substituto ósseo sintético associado a membrana de colágeno absorvível na preservação da crista óssea alveolar após extração dentária. Estudo clínico e tomográfico em humanos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/58/58132/tde-20032015-111906/.
Повний текст джерелаObjective: The aim of this randomized controlled clinical trial was to evaluate the use of a synthetic bone substitute associated with an absorbable collagen membrane in preserving the alveolar crest after tooth extraction, through clinical and tomography analysis in humans. Methods: Fourteen patients were selected, each featuring at least two front teeth jaws indicated for extraction: in Test Group (TG), the post-extraction sockets were filled by the synthetic bone substitute ReproBone, and the control group (CG) was filling the alveoli only by clot. In both groups, the wells were covered with a resorbable collagen membrane (BioMend), which in turn was covered with a mucoperiosteal flap closed occlusally. CT Cone Beam type were performed in the immediate postoperative period and after 6 months of surgery, and the horizontal and vertical dimensional changes of the bone crests were quantified. For intra-group statistical analysis used the paired t test; to intergupo reviews, unpaired t test. In all comparisons was adopted a 5% significance level. Results: Vestibular Vertical Measure reabsorbed 1.5 mm (or 21.3%) of the original measure in the test group (p <0.05) and 1.8 mm (or 25.8%) in the control group (p <0 , 05). The Measured Vertical Palatine 0.3 mm decreased in both groups (p> 0.05). The Maximum Height reduced 0.5 mm or 7.9% for the ReproBone and BioMend compared to baseline (p> 0.05), and 1.1 mm or 14.8% for the BioMend only (p <0.05 ), statistically significant intergroup difference (p <0.05). Measure the horizontal apical decreased by 0.2 mm WG, equivalent to 2.9% (p> 0.05), whereas the CG 0.5 mm or decreased by 7.3% (p <0.05), not statistically significant difference between groups. The Horizontal Cervical Measure (MHC) lost 0.5 mm or 7.2% in GT and 1.4 mm or 15.1% of CG: the intra-group analysis showed statistical difference between the initial data and after 6 months for this parameter (p <0.05) in both groups, and was also a statistically significant difference between groups in the evaluation for the MHC. Conclusion: The results showed that the use of ReproBone associated with BioMend presented benefits and better results in vertical and horizontal maintenance of alveolar ridge compared to using only the collagen membrane.
Ferreira, Sabrina [UNESP]. "Reconstrução alveolar por aumento do assoalho do seio maxilar com beta-tricálcio fosfato ou osso autógeno para reabilitação com prótese implantossuportada." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152077.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
A altura insuficiente do osso alveolar é um fator limitante para a reabilitação oral com próteses implantossuportadas. Taxas de sucesso clínico com uso de biomateriais à base de beta-tricálcio fosfato (b-TCP) para elevação do assoalho do seio maxilar (EASM) mostraram que são excelentes alternativas ao osso autógeno (OA). Portanto, objetivo foi avaliar a formação óssea do enxerto de b-TCP em bloco, seis meses após EASM, comparada ao OA por meio de análises tomográfica, microtomográfica e histomorfométrica. Para isso, Oito seios maxilares foram enxertados com b-TCF e sete OA. Após 6 meses, foram obtidas biópsias durante à instalação de implantes dentários. Não houve diferença significante (ANOVA) entre a contração do volume dos seios maxilares preenchidos por OA e b-TCP (p=0,113), bem como para todos os parâmetros microtomográfico (ANOVA) BV/TV (p=0.089), Tb.Th (p=1.000), Tb.Sp (p=0,989) e Tb.N (p=0.917). Na histomorfometria quando comparada a porcentagem ósseo em OA e b-TCP também não foi encontrada diferença estatística (ANOVA, p=0,794). Em conclusão, os resultados deste estudo indicam que ambos OA e b-TCP são adequados para o uso com segurança para o procedimento de EASM pela técnica da janela lateral. O material sintético apresenta boa estabilidade volumétrica com formação óssea semelhante ao OA suportada pelos parâmetros em análises 2D e 3D que se complementam. No entanto, a metodologia da análise volumétrica utilizada neste estudo parece representar a estabilidade volumétrica geral do procedimento, não somente do biomaterial, quando na técnica for utilizado o enxerto em bloco e não particulado.
The insufficient height of the alveolar bone is a limiting factor for oral rehabilitation with implants. Clinical success rates using beta-tricalcium phosphate (b-TCP) biomaterials for maxillary sinus floor elevation (MSFE) have been shown to be excellent alternatives to autogenous bone (AB). Therefore, the objective was to evaluate bone formation of the b-TCP graft in a block, six months after MSFE, compared to AB by means of tomographic, microtomographic and histomorphometric analyzes. For this, eight maxillary sinuses were grafted with b-TCF and seven AB. After 6 months, biopsies were obtained during the installation of dental implants. There was no significant difference (ANOVA) between the volume contraction of the maxillary sinus filled by AB and b-TCP (p = 0.113), as well as for all microtomographic parameters (ANOVA) BV/TV (p = 0.089), Tb.Th (p = 1.000), Tb.Sp (p = 0.989) and Tb.N (p = 0.917). In histomorphometry, when comparing bone percentage in AB and b-TCP, no statistical difference was found (ANOVA , p = 0.794). In conclusion, the results of this study indicate that both AB and b-TCP are suitable for safe use for the MSFE procedure by the side window technique. The synthetic material presents good volumetric stability with bone formation similar to AB supported by the parameters in 2D and 3D analyzes that complement each other. However, the volumetric analysis methodology used in this study seems to represent the general volumetric stability of the procedure, not only of the biomaterial, when in graft and non-particulate graft technique.
Rosa, Jucely Aparecida da. "Estudo da reparação óssea em fêmures de ratas sob a ação local do residronato de sódio /." São Jose dos Campos : [s.n.], 2011. http://hdl.handle.net/11449/95865.
Повний текст джерелаBanca: Vanessa Ávila Sarmento Silveira
Banca: Luiz Eduardo Blumer Rosa
Resumo: Esta pesquisa avaliou o efeito do uso local do residronato de sódio, em diferentes concentrações molares, no processo de reparação de defeitos ósseos em fêmures de ratas. Foi confeccionado no fêmur de 60 ratas um defeito ósseo medindo 2,5 mm de diâmetro. Estes animais foram divididos em grupos: controle (C), amido (Am), residronato 0,25 mol (Res 0,25), residronato 0,5 mol (Res 0,50), residronato 0,75 mol (Res 0,75) e residronato 1 mol (Res 1), de acordo com o material de preenchimento utilizado. Nos animais do grupo controle o defeito ficou preenchido apenas pelo coágulo. Os animais foram eutanasiados aos sete e 21 dias, e o fêmur foi removido, fixado e descalcificado, para a confecção de lâminas histológicas. Foram realizadas análises histológica e histomorfométrica, e os dados obtidos foram submetidos à análise estatística ANOVA. Histologicamente, as principais diferenças ocorreram após 21 dias. Os grupos C e Am apresentaram fechamento em extensão do defeito ósseo em todos os espécimes e a maioria dos animais dos grupos tratados com residronato em diferentes concentrações molares não exibiu neoformação óssea na região central do defeito, permanecendo este preenchido por tecido conjuntivo. Nos períodos de sete e 21 dias não houve diferença estatística significante entre os grupos C e Am em relação a neoformação óssea. Estatisticamente, não houve diferença entre os grupos Res 0,25; Res 0,50; Res 0,75 e Res 1 no período de sete dias. Já no período de 21 dias o grupo Res 0,25 apresentou a maior média, mas não diferiu estatisticamente do grupo Res 0,75. Concluiu-se que o residronato de sódio em todas as concentrações molares, prejudicou a reparação óssea nesse modelo experimental. No entanto, foi observada uma neoformação óssea extra-cortical subperiosteal nos grupos que receberam residronato.
Abstract: This work evaluated the action of sodium residronate, in different molars concentrations, in the repair of bone defects in femurs of rats. A bone defect measuring 2,5 mm in diameter was made in the femur of 60 rats. These animals were divided in groups: control (C), starch (Am), residronate 0,25 mol (Res 0,25), residronate 0,50 mol (Res 0,50), residronate 0,75 mol (Res 0,75), residronate 1 mol (Res 1), in accordance with the material of fill used. In the animals of the control group, the defect was just filled by the clot originating from the defect. The animals were euthanized at seven and 21 days, when the femur was removed, fixed and decalcified, to make histologicals laminae. Histological and histomorphometric analyses were performed and the results obtained were submitted to statistical analysis ANOVA. Histologically, the principal differences occurred after 21 days. The groups C and Am, showed an extension closure of bone defect in every specimen and most animals in groups treated with residronate in different molar concentrations did not show bone neoformation in the central region of the bone defects, which remained filled with connective tissue. After seven and 21 days, there was no significant statistical difference among groups C and Am in relation to bone neoformation. Statistically, there were no differences among the groups Res 0,25; Res 0,50; Res 0,75 e Res 1 in the period of seven days. In the period of 21 days, the group Res 0,25 had the highest average, but did not differ statistically from the Res 0,75. It was concluded that the sodium residronate in all the molar concentrations, harmed the bone repair in this experimental model. However, there was an extracortical subperiosteal bone neoformation in groups receiving residronate.
Mestre
Fernandes, Patricia Garani. "Utilização da matriz dérmica acelular e matriz óssea inorgânica/P-15 na preservação das deformidades da crista óssea alveolar após extração dentária em humanos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/58/58132/tde-12082010-164131/.
Повний текст джерелаBackground: Preventing ridge collapse with the extraction of maxillary anterior teeth is vital to an esthetic restorative result. Several techniques are available to regenerative procedures and are used for socket preservation. The aim of this study was to analyze by clinical parameters the use of acellular dermal matrix (ADM) and anorganic bovine bone matrix (ABM) with a synthetic cell-binding peptide P-15 to preserve alveolar bone after tooth extraction. Methods: Eighteen patients in need of extraction of maxillary anterior teeth were selected and they were randomly assigned to the test (ADM plus ABM/P-15) or control (ADM only). Clinical measurements were recorded at initial and 6 months after ridge preservation procedures. Results: In the clinical measurements - External Vertical Palatal, External Vertical Buccal and Alveolar Horizontal (EVPM, EVBM and AHM) -, the statistical analysis showed no difference between test and control groups in the initial and at six months. The intragroup analysis, after six months, showed a statistically significant reduction in the measurements for both groups. In the comparison between the groups, the differences (mm), in the test group, were: EVLM=0.83±1.53, EVBM=1.20±2.02, AHM=2.53±1.81 and in the control were: EVLM=0.87±1.13, EVBM=1.50±1.15, AHM=3.40±1.39. The differences in EVLM and EVBM measurements were no statistically significant; however, in horizontal measurement (AHM), there was statistically difference (p<0.05). Conclusion: The results of this study show that ADM, with or without ABM/P-15, can be successfully when it is used as a membrane for preservation of alveolar ridge after tooth extraction of maxillary teeth earlier.
Rodrigues, Rui Alexandre Cardoso. "Regeneração óssea vertical na reabilitação com implantes: resultados a longo prazo." Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5280.
Повний текст джерелаOs procedimentos de Regeneração Óssea Guiada (ROG) visam fornecer ao paciente melhoras, a nível estético e funcional, aumentando o volume e disponibilidade óssea. Actualmente realizam-se procedimentos para aumento do rebordo ósseo com o intuito de possibilitar a colocação de implantes dentários e melhorar a sua estética. Será descrita nesta revisão bibliográfica a Regeneração Óssea Guiada (ROG) para aumento vertical do rebordo alveolar e posterior colocação de implantes, bem como a previsibilidade da técnica e as suas taxas de sucesso. Existem vários materiais disponíveis para a técnica de ROG vertical, porém as membranas de politetrafluoroetileno expandido não-reabsorvível (PTFE-e) com reforço de titânio em associação com enxerto (1:1) autógeno e mineral de osso bovino desproteinizado (DBBM) constituem, actualmente, a primeira escolha quando se pretende o aumento ósseo vertical. A ROG para aumento vertical, apresenta boas taxas de sucesso e previsibilidade, contudo necessita de um operador com experiencia pois é uma técnica de muita exigência. Esta técnica pode ser realizada prévia ou em simultâneo com a colocação dos implantes.
Guided Bone Regeneration (GBR) procedures aim to provide the patient with aesthetical and functional improvements, increasing the bone volume and availability. Currently, procedures to increase the bone ridge are undertaken with the objective of allowing the placement of dental implants and improve their aesthetical appeal. Guided Bone Regeneration (GBR) for the vertical augmentation of the alveolar ridge and consequent implant placement will be described in this bibliographical review, as well as the predictability of the technique and its success rates. There are several materials available for the vertical GBR technique, however the membranes of expanded non-resorbable polytetrafluoroethylene (PTFE-e) with titanium reinforcement in association with autogenous graft (1:1) and deproteinized bovine bone mineral (DBBM) currently represent the first choice when a vertical bone augmentation is intended. The GBR for vertical augmentation features good success rates and predictability, however it requires an experienced operator, as it is a demanding technique. This can be performed previously or simultaneously with the placement of implants.
IVIGLIA, GIORGIO. "DESIGN, DEVELOPMENT AND CHARACTERIZATION OF NOVEL BIOMATERIALS FOR PERIODONTAL TISSUE ENGINEERING." Doctoral thesis, Politecnico di Torino, 2016. http://hdl.handle.net/11583/2643569.
Повний текст джерелаHattingh, André Christiaan. "A protocol to study tissue regeneration in alveolar bony defects /." Access to E-Thesis, 1999. http://upetd.up.ac.za/thesis/available/etd-01052007-135643/.
Повний текст джерелаTsiomis, Alexandre Couto. "Biovidro particulado no processo alveolar da mandíbula de cães. Avaliações clínico-cirúrgica, radiográfica e histológica." Universidade Federal de Viçosa, 2004. http://locus.ufv.br/handle/123456789/4993.
Повний текст джерелаThe use of dental implants is a common practice in human patients, and the demand for this service in small animals has increased in the last years. For the placement of dental implants it is necessary the existence of an alveolar bone bed of good quality and in enough quantity. Several factors such as periodontal disease and dental loss can cause reabsorption of the alveolar bone, thus enabling the placement of these implants. The objective of this work was to evaluate, through clinical, radiographic and histological analyses, the bioglass as a bone substitute in the regeneration of the alveolar process of the jaw of dogs. For such, 28 healthy adult mongrel dogs, males and female, weighing between 10 and 15 Kg, randomly divided in two groups, were observed during 120 days. Defects of approximately 6 x 5 x 5 mm were created in the vestibular surface of the alveolar process between the roots of the right fourth premolar tooth. In a group, the defect was immediately filled with bioglass, while in the other it did not receive any treatment, being used as control. Clinical evaluations were accomplished daily during one week. Radiographies were taken soon after the surgery and at 8, 14, 21, 42, 60, 90 and 120 days of the postoperative. Most of the animals of both groups did not present inflammation signs and the healing of the surgical wound happened in a similar way. The radiographic exams revealed gradual increase of the radiopacity in the area of the defect in the control group. In the treated group, it was initially observed superior radiopacity compared to the neighbor bone, which decreased on the 21st day of postoperative. Then the radiopacity began to gradually increase until 120 days after the surgery, when the defect became imperceptible. For the histologic analysis samples of the bone defect area of 2 animals of each group were collected after 8, 14, 21, 42, 60, 90 and 120 days of the surgery. In the control group it was observed that the bone deposition process began on the day 14th, developing progressively until the day 120th, when there was not limit between the margins of the defect and the neoformed bone. In the treated group it was observed at 8 days of postoperative the presence of loose connective tissue highly vascularizated around the bioglass particles. At 14 days, it was observed the bone formation process starting from the borders of the defect. On the 60th day of postoperative the bioglass had been totally reabsorbed and the defect was completely filled by trabecular bone. At 120 days, it was not possible to differentiate the neighbor bone of the defect area. Therefore, it can be concluded that the bioglass presents desirable characteristics to a bone substitute such as antibacterial and hemostatic effect, biocompatibility and osteoconductive property, being a valuable alternative for the alveolar bone regeneration.
A utilização de implantes dentários é prática comum em humanos, e a demanda por este serviço em animais de estimação tem aumentado nos últimos anos. Para o emprego de implantes dentários é necessário a existência de um leito de osso alveolar de boa qualidade e em quantidade suficiente. Vários fatores tais como a doença periodontal e a perda dentária podem levar à reabsorção do osso alveolar, impedindo a colocação destes implantes. O objetivo deste trabalho foi avaliar, por meio de análises clínico-cirúrgica, radiográfica e histológica, o biovidro como substituto ósseo na regeneração do processo alveolar da mandíbula de cães. Para tal, foram utilizados 28 cães adultos clinicamente saudáveis, machos e fêmeas, pesando entre 10 e 15 kg, divididos aleatoriamente em dois grupos iguais e observados durante 120 dias. Foram criados defeitos de aproximadamente 6 x 5 x 5 mm na superfície vestibular do processo alveolar entre as raízes do dente quarto pré-molar direito. Em um grupo, o defeito foi imediatamente preenchido com biovidro, enquanto no outro este permaneceu sem preenchimento, sendo utilizado como controle. Foram realizadas avaliações clínicas diariamente durante uma semana, assim como radiografias logo após a cirurgia e aos 8, 14, 21, 42, 60, 90 e 120 dias do pós-peratório. A maioria dos animais dos dois grupos não apresentou sinais de inflamação e a cicatrização da ferida cirúrgica ocorreu de forma semelhante. O exame radiográfico revelou aumento gradual da radiopacidade na região do defeito no grupo controle. No grupo tratado, observou-se inicialmente radiopacidade superior à do osso vizinho, com diminuição desta até os 21 dias de pós-operatório, voltando a aumentar gradativamente até os 120 dias do pós-cirúrgico, quando a falha tornou-se imperceptível. Aos 8, 14, 21, 42, 60, 90 e 120 dias do pós-operatório também foram coletadas amostras da região da falha óssea de 2 animais de cada grupo para a análise histológica. Observou-se que no grupo controle o processo de deposição óssea iniciou-se aos 14 dias, evoluindo progressivamente até que aos 120 dias não havia mais limite entre as margens do defeito e o osso neoformado. Já no grupo tratado observou-se logo aos 8 dias de pós-operatório a presença de tecido conjuntivo frouxo altamente vascularizado ao redor das partículas de biovidro. Aos 14 dias iniciou-se o processo de formação óssea a partir das bordas da falha, até que aos 60 dias o biovidro havia sido totalmente reabsorvido e o defeito apresentava-se completamente preenchido por osso trabecular. Aos 120 dias, não foi mais possível diferenciar o osso vizinho da região da falha. Portanto, pode-se concluir que o biovidro apresenta características desejáveis a um substituto ósseo tais como efeito antibacteriano e hemostático, biocompatibilidade e propriedade osteocondutora, sendo uma alternativa viável quando objetiva-se a diminuição do tempo de reparação do osso alveolar.
Fófano, Gisele. "Matriz óssea bovina mineralizada na reparação alveolar da mandíbula de cães e sua associação com membrana de colágeno. Estudo experimental." Universidade Federal de Viçosa, 2004. http://locus.ufv.br/handle/123456789/4989.
Повний текст джерелаThe periodontal therapies have as objectives not only to stop the progression of the disease, by the interruption of the inflammatory action of the bacterial plate, but also to make possible the restoration of the lost structures, especially as for the maintenance of the architecture and the functional state of those. Thus, the obtained treatments as regenerative or reconstrutivos present as a purpose the formation of new insertion tissues (cement, periodontal linking and alveolar bone) in the involved area by the periodontopaty. Examples of regenerative periodontal therapies include bone grafts and guided tissue regeneration (GTR). The objective of this work was to evaluate the mineralized bovine bone matrix as a substitute bone in the alveolar repairing of the jaw of dogs and its association with a collagen membrane a following the technique of the guided tissue regeneration (GTR). For such, 48 dogs were used, divided in three groups. Defects of approximately 6 x 5 x 5 mm were created among the roots of the fourth right premolar in the vestibular surface of the alveolar bone. In a group, those defects were totally filled out with the xenograft, and in another group, the defect was totally filled out with the xenograft and covered by the membrane, while in the last group, they stayed without treatment, being used as control. Daily clinical evaluations were accomplished for one week, as well as radiographic soon after the surgery and to the 7, 14, 21, 30, 42, 60, 90 and 120 days. The cicatrization of the surgical wound happened in a satisfactory and similar way among the dogs of the three groups. The radiographic exam revealed a slower repairing in the control group, where to the 120 days the defect was still visualized, in comparison with the group treated with the mineralized bovine bone matrix, than to the 60 days was not observed anymore and in comparison with the group treated with the mineralized bovine bone matrix and collagen membrane, than to the 90 days the failure was not visualized anymore. Therefore, it can be concluded that the used materials presented desirable characteristics as biocompatibility and property osteoconductor, being viable alternatives in the aid of the alveolar bone repairing. It was collected, from two animals of each group, material for biopsy of the operated ranch at the 7, 14, 21, 30, 42, 60, 90 and 120 days and histological evaluations were accomplished. In the control group, the bone formation process began at the 14th day and it developed progressively until the 120th day, when the limit between the periphery of the flaw and the new formed bone was not more distinguishable. In the group treated only with the mineralized bovine bone matrix, right at seventh it was observed abundant cellularity around the material and the beginning of the repairing process, that it had already filled out the whole produced defect at the 60 th day. Besides, no reaction of the strange body type was observed and, therefore, it can be concluded that the used material presents desirable characteristics to a substitute bone as biocompatibility and property osteoconductor, being an alternative for the aid of the alveolar bone repairing. In the group treated with the mineralized bovine bone matrix and collagen membrane, a more advanced repairing process was observed in relation to the control group until the 42 th day. Then, a chronic inflammatory process was observed, until the 120 th day, taking it to a repairing bone stagnation. In spite of that, no reaction of the strange body type was observed and, therefore, it can be concluded that the used materials present biocompatibility, desirable characteristic to substitute bone and that the membrane, starting from the 42 th day, provokes undesirable reaction.
As terapias periodontais têm como objetivos não apenas estacionar a progressão da doença, pela interrupção da ação inflamatória da placa bacteriana, mas também possibilitar a restauração das estruturas perdidas, especialmente quanto à manutenção da arquitetura e estado funcional dessas. Assim, os tratamentos tidos como regenerativos ou reconstrutivos apresentam como finalidade a formação de novos tecidos de inserção (cemento, ligamento periodontal e osso alveolar) na área envolvida pela periodontopatia. Exemplos de terapias periodontais regenerativas incluem enxertos ósseos e regeneração tecidual guiada (RTG). O objetivo deste trabalho foi avaliar a matriz óssea bovina mineralizada como substituto ósseo na reparação alveolar da mandíbula de cães e sua associação com uma membrana de colágeno seguindo a técnica da regeneração tecidual guiada (RTG). Para tal, foram utilizados 48 cães, divididos em três grupos. Defeitos de aproximadamente 6 x 5 x 5 mm foram criados entre as raízes do quarto pré-molar direito na superfície vestibular do osso alveolar. Em um grupo, esses defeitos foram totalmente preenchidos com o xenoenxerto, em outro grupo, o defeito foi totalmente preenchido com o xenoenxerto e coberto pela membrana, enquanto no último grupo, permaneceram sem tratamento, sendo utilizados como controle. Foram realizadas avaliações clínicas diárias por uma semana, assim como radiográficas logo após a cirurgia e aos 7, 14, 21, 30, 42, 60, 90 e 120 dias. A cicatrização da ferida cirúrgica ocorreu de forma satisfatória e semelhante entre os cães dos três grupos. O exame radiográfico revelou uma reparação mais lenta no grupo controle, onde aos 120 dias o defeito ainda foi visualizado, em comparação ao grupo tratado com a matriz óssea bovina mineralizada, que aos 60 dias não foi mais observado e em comparação ao grupo tratado com a associação matriz óssea bovina mineralizada e membrana de colágeno, que aos 90 dias a falha não foi mais visualizada. Portanto, pode-se concluir que os materiais utilizados apresentam características desejáveis como biocompatibilidade e propriedade osteocondutora, sendo alternativas viáveis no auxílio da reparação óssea alveolar. Foi coletado, de dois animais de cada grupo, material para biópsia do sítio operado aos 7, 14, 21, 30, 42, 60, 90 e 120 dias e foram realizadas avaliações histológicas. No grupo controle, o processo de formação óssea se iniciou aos 14 dias e evoluiu progressivamente até os 120 dias, quando não foi mais distinguível o limite entre a periferia da falha e o novo osso formado. No grupo tratado somente com a matriz óssea bovina mineralizada, logo ao sétimo dia observou-se abundante celularidade ao redor do material e o início do processo de reparação, que aos 60 dias já havia preenchido todo o defeito produzido. Além disso, nenhuma reação do tipo corpo estranho foi observada e, portanto, pode-se concluir que o material utilizado apresenta características desejáveis a um substituto ósseo como biocompatibilidade e propriedade osteocondutora, sendo uma alternativa para o auxílio da reparação óssea alveolar. No grupo tratado com a associação matriz óssea bovina mineralizada e membrana de colágeno, observou-se o processo de reparação mais avançado em relação ao grupo controle até os 42 dias. Depois, observou-se um processo inflamatório crônico, até os 120 dias, levando a uma estagnação dessa reparação óssea. Apesar disso, nenhuma reação do tipo corpo estranho foi observada e, portanto, pode-se concluir que os materiais utilizados apresentam biocompatibilidade, característica desejável a substitutos ósseos e que a membrana, a partir dos 42 dias, provoca reação indesejável.
Nart, Molina José. "Estudio Prospectivo Comparativo de la Eficacia en el Aumento Horizontal de Crestas Alveolares Atróficas con Regeneración Ósea Guiada y Expansores Motorizados de Cresta." Doctoral thesis, Universitat Internacional de Catalunya, 2010. http://hdl.handle.net/10803/9340.
Повний текст джерелаEl propósito de esta investigación clínica prospectiva y aleatoria es comparar el aumento horizontal de la cresta alveolar obtenido con el uso de los expansores motorizados de cresta (EMC) y con regeneración ósea guiada (ROG). Fueron selecccionados ocho pacientes con deformidades horizontales del reborde alveolar bilaterales que iban a recibir implantes dentales. Una técnica de regeneración se utilizó en el lado derecho y la otra en el lado izquierdo, para un total de 23 muestras, 13 en el lado experimental (EMC) y 10 en el lado control (ROG). Los implantes fueron colocados seis meses después de los procedimientos de aumento óseo, y se obtuvo una muestra de hueso para estudio histológico. Todas las mediciones clínicas se registraron a los 2 y 5 mm de la parte más coronal de la cresta. El aumento logrado con ambas técnicas fue estadísticamente significativo, de 1,2 mm en la ROG y 1,5 mm con los EMC a 2 mm de la cresta; y 1,5 mm y 1,6 mm, respectivamente, a 5mm de la cresta. Las diferencias entre las dos técnicas no fueron estadísticamente significativas. La cantidad de expansión lograda en el sitio de los EMC parece tener una correlación negativa (p <0,05) con el grosor del hueso esponjoso, y no se ve afectada por el grosor de la cortical. Histológicamente se observó osteoconductividad del injerto óseo y más partículas residuales del mismo en el lado experimental. La técnica de los EMC parece ser tan eficaz como la técnica de ROG en el aumento de la anchura de las crestas atróficas. Los defectos tratados con los EMC mostraron una menor contracción del injerto óseo durante los 6 meses de cicatrización.
El propòsit d'aquesta recerca clínica prospectiva i aleatòria és comparar l'augment horitzontal de la cresta alveolar obtingut amb l'ús dels expansors motoritzats de cresta (EMC) i amb regeneració òssia
guiada (ROG). Es van selecccionar vuit pacients amb deformitats horitzontals bilaterals de la cresta alveolar on es col.locaren implants dentals. Una tècnica de regeneració es va emprar en el costat dret i l'altra a la banda esquerra, per a un total de 23 mostres, 13 al costat experimental (EMC) i 10 en el costat control (ROG). Els implants van ser col.locats sis mesos després dels procediments d'augment ossi, i es va obtenir una mostra d'os per estudi histològic.Totes les mesures clíniques es van registrar als 2 i 5 mm de la part més coronal de la cresta. L'augment aconseguit amb ambdues tècniques va ser estadísticament significatiu, de 1,2 mm a la ROG i 1,5 mm amb els EMC a 2 mm de la carena, i 1,5 mm i 1,6 mm, respectivament, a 5mm de la cresta. Les diferències entre les dues
tècniques no van ser estadísticament significatives. La quantitat d'expansió aconseguida en el lloc dels EMC sembla tenir una correlació negativa (p<0,05) amb el gruix de l'os esponjós, i no es veu afectada per el gruix de la cortical. Histològicament es observar osteoconductividad l'empelt ossi i més partícules residuals d'aquest en el costat experimental. La tècnica dels EMC sembla ser tan eficaç com la tècnica de ROG en l'augment de l'amplada de les crestes atròfiques. Els defectes tractats amb els EMC mostrar una menor contracció de l'empelt ossi durant els 6 mesos de cicatrització.
Kirkland, Virginia M. "Guided bone regeneration of alveolar ridge defects utilizing a Guidor resorbable membrane and bone graft." 1998. http://catalog.hathitrust.org/api/volumes/oclc/48209119.html.
Повний текст джерелаWeng, Shiang-Ting, and 翁湘婷. "Preparing Bone-like Tissues in the Self-designed Bioreactor System for Alveolar Bone Regeneration." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/mx9j7p.
Повний текст джерела國立臺北科技大學
化學工程與生物科技系生化與生醫工程碩士班
105
According to statistics compiled by the Ministry of Health and Welfare of Taiwan, Taiwan has the highest population ratio of periodontal disease in Asia. If people have not a good health habits of oral and regular inspection will lead to bacterial plaque formation; further invade to the cementum, periodontal ligaments and alveolar bone, will eventually lead to loose teeth and fall off. When patients with severe alveolar bone damage can not be prosthetic rehabilitation, autologous bone graft is widely considered as the gold standard for the treatment of the bone reconstruction, it can avoid immune response, but the risk of second surgery may cause morbidity in the donor site. The most important, the limited source of tissue that can be obtained. Therefore, in vitro reconstruction and regeneration of alveolar bone tissue research is an urgent issue, but the development of suitable for clinical use and functional organization is still quite difficult challenges. In this study, we establish a strategy, which combines Ca-Alginate scaffolds and rat bone marrow stem cells (bm-MSCs), for bone-like tissues formation. We had developed the self-designed bioreactor system previously, in vitro to three-dimensional dynamic culture of bone-like tissue to carry out autologous alveolar bone graft. This technology mainly uses the Ca-Alginate scaffolds to provide three-dimensional growth environment, porous structure helps nutrient permeability, bone-like tissue formation, without any enzyme treatment can be collected, bioreactor simulation of the human circulatory system , closed reflux system not only help cell proliferation and differentiation, but also to cell secretion of growth factors and cytokines can be fed back to the cells in culture, and reduce the incidence of human pollution. The self-designed bioreactor system is cost-effective and able to reduce the risk of contamination. We can get enough bone-like tissues cultivated in vitro under high-throughput process in the closed-loop system. In the future, we hope this technology can provide another choice for patients and clinical doctors.
Fang, Yen-Hsin, and 方妍心. "Collagenase/Hyaluronic acid/Hydroxyapatite and Gypsum as Scaffold for Alveolar Bone Regeneration." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/12448002445438001541.
Повний текст джерела國立臺灣大學
醫學工程學研究所
101
With the global prevalence of periodontitis which leads to irreversible bone loss, the regeneration of bone tissue poses a challenge to engineers and clinicians. The importance of alveolar bone cannot be overemphasized since it is one of the tooth-supporting structures. In the past few years, the research of growth factor for alveolar bone regeneration is blooming, but still remains controversial due to its instability and high cost. Instead of using growth factors, we hypothesized that cells could be recruited from extracellular matrix for bone repair by collagenase treatment without any autologous grafts. Hence, the purpose of this study is to evaluate the bone regenerative capacity after the implantation of hydroxyapatite and calcium sulfate (gypsum) with hyaluronic acid carrying collagenase in the rat model. In the study, the setting time, compressive strength, release characteristics and biocompatibility of Hyaluronic acid/Collagenase/Hydroxyapatite/Calcium sulfate were evaluated. The potential for reconstruction of destroyed alveolar bone by the implanted composite was also tested in rat model. The initial setting time of the composite was 21 minutes which is adequate for clinicians to handle. The compressive strength of composites after immersion in phosphate buffered saline solution in 7 days was 6.5MPa, and decreased after 2 weeks. The release profile shows 60 % of collagenase incorporated in the composite was released in 30 minutes that coincides with the time of collagenase digestion normally used in primary culture. The good biocompatibility of the composite was also confirmed by WST-1 test which indicates no significant difference between control group and experimental group. In animal study, the result of the composite HA/Collagenase/HAP/CS in 12-week after surgery was superior to other groups including commercial product Bio-OssR. Evidence of obvious regeneration in bone defects treated with HA/Collagenase /HAP/CS can be observed in micro-CT images histological results. Then we can conclude that it might be feasible for collagenase treatment to recruit more cells during healing process. In the future, the study can be applied to canines as an animal model for further confirmation.
Cenicante, João Pedro Alves Valadas de Lima. "The use of autogenous teeth for alveolar ridge preservation : a literature review." Master's thesis, 2021. http://hdl.handle.net/10400.26/38444.
Повний текст джерелаFollowing a tooth extraction, a cascade of biological events will lead inevitably to a decrease in the height and width of the alveolar ridge, mostly on the buccal side and horizontally. In this sense, given how often this procedure is performed in dental practice, it is pivotal that every clinician is acquainted with these dimensional changes and its possible impact on future oral rehabilitation. Consequently, several treatment modalities, commonly known as Alveolar Ridge Preservation (ARP) are described in the literature and include: socket grafting, with the use of a bone graft material, guided tissue regeneration (GTR), with the use of a barrier membrane and finally guided bone regeneration (GBR) with the use both a bone graft material and a barrier membrane. Currently, there are several options for bone graft materials available to the clinician, comprising autografts, allografts, xenografts and alloplasts, having each its advantages and drawbacks. The biological plausibility regarding the use of these biomaterials is that thanks to biological properties intrinsic to the grafts, the alveolar ridge resorption would decrease. In the past decade, the use of autogenous teeth as a bone graft material has been described with encouraging results, nevertheless, describing distinct preparation protocols prior to the ARP procedure. Therefore, this literature review aims to summarize all the evidence regarding the use of autogenous teeth as a bone graft material in ARP in post-extraction sockets, its several preparation protocols, efficacy and future perspectives.
Após qualquer exodontia, uma série de eventos biológicos conduzem inevitavelmente a uma redução ao nível da altura e largura do rebordo alveolar, principalmente na componente vestibular e horizontalmente. Desta forma, dada a frequência com que este procedimento é realizado na Medicina Dentária, é fulcral que qualquer clínico esteja informado destas alterações dimensionais e possível impacto numa futura reabilitação oral. Consequentemente, diversas opções de tratamento, vulgarmente conhecido como Preservação da Crista Alveolar (PCA) foram descritas incluindo: regeneração óssea, através do uso de um enxerto ósseo, regeneração tecidular guiada (RTG), através do uso de uma membrana barreira e ainda regeneração óssea guida (ROG) com o uso de um enxerto ósseo associado uma membrana barreira. Atualmente, existem diversas opções de enxertos ósseos disponíveis para o clínico, compreendendo autoenxertos, aloenxertos, xenoenxertos e aloplásticos, tendo cada um vantagens e limitações. A plausabilidade biológica destes biomateriais pode ser explicada devido a propriedades biológicas intrínsecas ao enxerto ajudando a minimizar a reabsorção óssea. Na última década, o uso de dente autólogo como substituto ósseo tem sido descrito com resultados encorajadores, contudo, descrevendo protocolos de preparação distintos antes de realizar a PCA. Desta forma, esta revisão de literatura procura resumir a evidência disponível relativamente ao uso de dente autólogo como substituto ósseo na PCA em alvéolos pós-extração, os diversos protocolos de preparação, eficácia e perspetivas futuras.
Montez, Rita Salgueiro. "Alterações de rebordo alveolar após extração dentária com o sistema Benex Extractor." Master's thesis, 2017. http://hdl.handle.net/10316/82511.
Повний текст джерелаIntrodução: A perda de osso alveolar e tecidos gengivais pode decorrer por extração dentária, doença periodontal, processos infeciosos, entre outros. Daí existir uma importância extrema nas inovações contínuas relativas a técnicas cirúrgicas e compreensão biológica das técnicas de regeneração óssea. A preservação alveolar define-se como qualquer tipo de procedimento que tem como objetivo minimizar as reabsorções ósseas e maximizar a formação de osso dentro do alvéolo. Existem procedimentos pré-operatórios, intraoperatórios (extração atraumática) e técnicas de reconstrução alveolar pós-operatórias, recorrendo à utilização de diversos materiais tanto de origem autógena, endógena (Bancos de osso) ou xenógena (materiais que proporcionam uma matriz em muito semelhante à matriz óssea).Objectivos: O objetivo deste trabalho é elaborar uma revisão sistemática sobre os biomateriais de regeneração e documentar um caso clínico de cirurgia de preservação alveolar com recursos a membranas de PRP.Materiais e Métodos: Elaborou-se a questão PICO e com recurso a base de dados PubMed/Medlina e b-on, procedeu-se à pesquisa para a revisão da literatura. A cirurgia de preservação foi dividida em duas fases. A primeira fase de colheita sanguínea e a segunda fase, fase cirúrgica propriamente dita, na qual se extraiu um dente 14 ao qual estava associado um defeito infraósseo e preencheu-se o alvéolo com recurso ao agregado PRP. Foram realizados controlos aos 5 dias, 8 dias, 4 semanas, 8 semanas e 3 meses.Resultados: Da pesquisa foram selecionados 20 referências bibliográficas. Todas as técnicas reportaram melhorias significativas, no entanto quando comparadas entre si, estas não mostraram diferenças estatisticamente significantes. Relativamente ao caso clínico, a paciente teve uma excelente recuperação com bom preenchimento do alvéolo 2 meses após a cirurgia. Conclusão: Apesar dos resultados satisfatórios, as bases para a seleção de um material em detrimento de outro não são claras nem estão devidamente definidas quanto à sua aplicação nas várias situações clínicas, sendo necessário mais estudos neste sentido. É de salientar os aspetos práticos do PRP, apesar de acrescentar mais passos durante a cirurgia, consiste num preparado proveniente do próprio paciente sendo o risco de transmissão de patogenes inexistente, constituindo uma alternativa de tratamento viável e segura.
Introduction: The loss of alveolar bone and gingival tissues may be due to, for exe,ple, tooth extraction and periodontal disease. So there’s na extreme importance in the continuous innovationsrelated to surgical techniques and biological understanding of the techniques for bone regeneration. Alveolar preservation is defined as a procedure that aims to minimize bone resorption and maximize the formation of bone within the socket. There are many procedures that can be perform before, during or after na extraction, like alveolar reconstrucion. For this, there are several materials available, like autografts, being the choice material with perfect compatibility, endogenous grafts, xenogafts and others materials.Objective: The aim of this work was to elaborate a Sistematic review on biomaterials for bone regeneration and document a curgical case of alveolar preservation with PRP membrans.Materials and methods: PICO question was elaborated and with de use of PubMed/MEDLINE e b-On database, the literature review was carried out. the surgery was divided into 2 phases, the first of blood collection and the second phase or surgical phase, the socket was filled with PRP agregate. Follow-ups were performed at 5 days, 8 days, 4 and 13 weeks.Results: 20 references weres selected for this study. All techniques reported significant improvements, however when compared with each other, they did not show significant diferences. Regarding the clinical case, the patient han na excelente recovery with good filling of the socket, 2 months after surgery.Conclusion: Despite the results, the protocol for the selection of one biomaterial over another is not properly defined in terms of its application in clinical situations, and further studies are necessary. PRP, despite adding more steps during the surgery, consist of a preparation form the patient’s blood, so the risk of transmission of psthogens doesn´t exist, constituting a safe and viable treatment.
Gründel, Marcel. "Experimentelle Untersuchung zur Alveolarkammaugmentation mit Poly-(D,L-)Laktid-Membranen." Doctoral thesis, 2015. http://hdl.handle.net/11858/00-1735-0000-0022-5DD9-F.
Повний текст джерелаMaazou, Samira Houria. "Aumento ósseo vertical." Master's thesis, 2017. http://hdl.handle.net/10284/6511.
Повний текст джерелаA few years ago, certain clinical acts aimed to restoring dental aesthetics, such as implants, were almost impossible without adequate bone height and thickness. Nowadays, through a process of bone regeneration we can restore sufficient conditions to recover or improve the configuration of the bone and thus be able to carry out the rehabilitation with implants. (Antoun, H. 2013, Karouni, M. 2013, Sojod B. 2013). There are several types of regeneration both horizontal and vertical, in this work we will study / we will focus on vertical regeneration. Objectives: First, let's take a brief look at the physiological basis of bone, more precisely the mechanisms of bone remodeling, then we will talk about vertical bone regeneration and explore the different techniques available for this purpose. Finally, we will highlight the indications, contraindications, advantages and disadvantages of each of them.
Hattingh, Andre Christiaan. "A protocol to study tissue regeneration in alveolar bony defects." Diss., 1999. http://hdl.handle.net/2263/26291.
Повний текст джерелаDissertation (MChD (Periodontics and Oral Medicine))--University of Pretoria, 2007.
Oral Pathology and Oral Biology
unrestricted
Laborie, Tiphaine Lisa. "Vantagens, desvantagens e aplicabilidade do enxerto ósseo autólogo em medicina dentária." Master's thesis, 2018. http://hdl.handle.net/10284/7181.
Повний текст джерелаA bone graft consists of carrying bone from an anatomical site (donor site) where it is abundant and where removal will only result in minimal consequences, to place it in another place where the bone volume is decreased (place of reception) and where it will improve esthetics and / or function. In the therapeutic arsenal of dental surgeries, a bone graft is indicated more frequently in one of the following situations: - Reconstructive and reconstructive facial surgery (post-traumatic sequelae, reconstruction of the jaws and contours of the facial bone). - Pre-implant surgery where the bone graft will restore sufficient bone volume to accommodate a dental implant. - Periodontal surgery where the bone graft will restore an abundant and normal supporting tissue around the tooth. There are several types of bone graft; The autograft is a bone graft taken from the person receiving the transplant. The bone is most often taken in the jaw, near the area to be grafted. For larger grafts, the bone may be removed, for example, from the iliac crest. There are external grafts of origin, the bone defect can then be filled by different materials of synthetic origin, human or animal. Alloplastic transplantation is a synthetic material, also known as alloplast, is a bone substitute produced in the laboratory. This material may or may not remain in the body; Some remain and become part of the new bone, while others dissolve, stimulating bone growth in the grafted area during its dissolution. The xenograft is an allograft, which means it does not come from the same person for whom the transplant is used. The bone material does not come from a human being, but from other species. The most commonly used is bovine xenograft. This means that the bone material is taken from a cow (treated, sterilized and naturally conditioned). Human allograft is a human bone taken from a person (treated, sterilized and packed) and used as a bone graft to be implanted in another person. The choice will be made according to the volume and position of the site to fill. None of the above materials is used systematically. The surgeon gives the indication according to the extent of the reconstruction, valuing the advantages and disadvantages of each of these materials.
CHEN, GUANG-XING, and 陳廣興. "The regeneration of the inferior alveolar nerve in bony canal model of the cat." Thesis, 1990. http://ndltd.ncl.edu.tw/handle/43123860613603367803.
Повний текст джерела