Готові списки джерел за темами / Alpha-enhanced

Добірка наукової літератури з теми "Alpha-enhanced"

Автор: Grafiati
Опубліковано: 14 березня 2023

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Статті в журналах з теми "Alpha-enhanced"

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Druliner, J. D., F. W. Hobbs, and W. C. Seide. "Concerning enhanced reactivities of .alpha.-keto hydroperoxides." Journal of Organic Chemistry 53, no. 3 (February 1988): 700–702. http://dx.doi.org/10.1021/jo00238a044.

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2

Addleman, R. S., M. J. O'Hara, J. W. Grate, and O. B. Egorov. "Chemically enhanced alpha-energy spectroscopy in liquids." Journal of Radioanalytical and Nuclear Chemistry 263, no. 2 (January 2005): 291–94. http://dx.doi.org/10.1007/s10967-005-0051-z.

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3

Oettinger, C. W., L. A. Bland, J. C. Oliver, M. J. Arduino, S. K. McAllister, and M. S. Favero. "The effect of uremia on tumor necrosis factor-alpha release after an in vitro whole-blood endotoxin challenge." Journal of the American Society of Nephrology 4, no. 11 (May 1994): 1890–95. http://dx.doi.org/10.1681/asn.v4111890.

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Uremia has been associated with immunologic aberrations, including anergy, increased susceptibility to infections, and reduced phagocytic activity of polymorphonuclear leukocytes. In this study, cytokine release in uremic and nonuremic blood after in vitro endotoxin stimulation was studied. Blood from nonuremic controls, chronic renal failure patients not on dialysis, and chronic hemodialysis patients predialysis and postdialysis was spiked with 10 ng/mL of Escherichia coli endotoxin and incubated for 2 and 26 h. Plasma tumor necrosis factor-alpha (TNF alpha) concentrations were determined by ELISA after each incubation period. To further study which uremic blood component may be responsible for enhanced release of TNF alpha, plasma and cellular components of chronic renal failure patients and controls were switched and then given an in vitro endotoxin stimulation (1 ng/mL). It was found that (1) TNF alpha release is enhanced by uremia and is exacerbated with progressive declines in renal function, (2) enhanced TNF alpha release is related to a blood cellular phenomenon induced by uremia, and (3) enhanced TNF alpha release in hemodialysis patients is associated with a prolonged stimulation and/or reduced plasma elimination of TNF alpha.
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4

Lajat, S., Z. Tanfin, G. Guillon, and S. Harbon. "Modulation of phospholipase C pathway and level of Gq alpha/G11 alpha in rat myometrium during gestation." American Journal of Physiology-Cell Physiology 271, no. 3 (September 1, 1996): C895—C904. http://dx.doi.org/10.1152/ajpcell.1996.271.3.c895.

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The regulation of the receptor-G protein-phospholipase C (PLC) cascade was investigated in rat myometrium at midgestation (day 12) and at term (day 21) comparatively to the estrogen-treated tissue (day 0). Carbachol-mediated generation of [3H]inositol phosphates was insensitive to pertussis toxin and was enhanced at days 12 and 21 two- and threefold, respectively, with no alteration of muscarinic sites (M3 subtype). A similar increase could be detected in the production of inositol 1,4,5-trisphosphate, indicating the stimulation of a PLC degrading phosphatidylinositol 4,5-bisphosphate. AlF4- also enhanced PLC activation during gestation, suggesting pregnancy-related regulations that bypass receptor activation. Immunoreactive G proteins, Gq alpha and G11 alpha, and PLC-beta 3 were detected in all myometrial preparations. The amount of PLC-beta 3 was similar in day 0 and day 21 myometrium, although decreasing by 75% at midgestation. Of significance was the increased amount of Gq alpha in day 12 and day 21 myometrium (3- and 2-fold, respectively) which coincided with the enhanced phosphoinositide breakdown. The upregulation of Gq alpha may contribute to the enhanced PLC activity during pregnancy and at term.
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5

White, R. E., and G. O. Carrier. "Enhanced vascular alpha-adrenergic neuroeffector system in diabetes: importance of calcium." American Journal of Physiology-Heart and Circulatory Physiology 255, no. 5 (November 1, 1988): H1036—H1042. http://dx.doi.org/10.1152/ajpheart.1988.255.5.h1036.

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Mesenteric arteries from streptozotocin (STZ)-diabetic rats developed greater contractile force in response to norepinephrine and related alpha-agonists than arteries from age-matched controls. Subsequent experiments attempted to define the mechanisms underlying these findings. Transmural nerve stimulation of mesenteric arteries from both groups of animals revealed a similar optimal frequency and voltage of stimulation; however, arteries from STZ-diabetic rats developed greater contractile force than controls. Second, determination of selective alpha-adrenergic antagonist affinities (pA2 values) revealed qualitatively similar postjunctional alpha 1-adrenoceptors in both groups of arteries. Third, disruption of the endothelium did not abolish the enhanced responsiveness of arteries from STZ-diabetic rats. In contrast, the increased vascular responsiveness in STZ-diabetes was associated with a greater dependency on extracellular calcium, with no change in the response to alpha-agonist-induced release of calcium from cellular stores. Thus the enhanced responsiveness of mesenteric arteries from STZ-diabetic rats to alpha-adrenergic agonists cannot be attributed to neuronal deterioration, altered postjunctional alpha-adrenoceptor subtypes, endothelium degeneration, or enhanced release of intracellular calcium but is associated with a greater dependency on extracellular calcium.
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John, R., R. Henley, and D. Shankland. "Evaluation of an enhanced luminescence assay for alpha-fetoprotein." Clinical Chemistry 32, no. 11 (November 1, 1986): 2066–69. http://dx.doi.org/10.1093/clinchem/32.11.2066.

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Abstract We evaluated a two-site enhanced luminescence immunoenzymometric assay (Amerlite; Amersham International) for alpha-fetoprotein (AFP) in maternal serum and amniotic fluid. The assay is rapid, involving two incubations totalling 4 h. The working range of the assay for serum AFP is 5.5 to 750 kilo-int. units/L (CV less than 10%), with a sensitivity of detection of 0.2 kilo-int. unit/L. The regression equation for the Amerlite assay (y) and our in-house RIA procedure (x) was y = 0.816x + 2.9 (n = 142, r = 0.96). Analytical recovery of added AFP (code 72/227) at three concentrations was 86.7%. Serum AFP concentrations were measured at 15 to 18 weeks of gestation in subjects with normal pregnancies and in subjects whose pregnancies resulted in open neural tube defects; all of the latter had serum AFP concentrations greater than 2.5 multiples of the median. We find the Amerlite system to be an efficient, reliable system for screening for open neural tube defects without use of hazardous radioactive labels.
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7

Shu, San-Ging. "Alpha-gamma equalization-enhanced hand radiographic image segmentation scheme." Optical Engineering 48, no. 10 (October 1, 2009): 107001. http://dx.doi.org/10.1117/1.3242852.

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Worley, Christopher G., Richard W. Linton, and Edward T. Samulski. "Electric-Field-Enhanced Self-Assembly of .alpha.-helical polypeptides." Langmuir 11, no. 10 (October 1995): 3805–10. http://dx.doi.org/10.1021/la00010a034.

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Dubois, Aurelie, Catherine François, Veronique Descamps, Carole Fournier, Czeslaw Wychowski, Jean Dubuisson, Sandrine Castelain, and Gilles Duverlie. "Enhanced anti-HCV activity of interferon alpha 17 subtype." Virology Journal 6, no. 1 (2009): 70. http://dx.doi.org/10.1186/1743-422x-6-70.

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Luo, Y., X. Chen, W. C. DeWolf, and M. A. OʼDonnell. "BCG EXPRESSING HUMAN INTERFERON-ALPHA 2B DEMONSTRATES ENHANCED IMMUNOGENICITY." Journla of Immunotherapy 22, no. 5 (September 1999): 463. http://dx.doi.org/10.1097/00002371-199909000-00046.

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Дисертації з теми "Alpha-enhanced"

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Murfin, Alice M. "Thermally enhanced colloidal processing of #alpha#-alumina." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283403.

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Quimper, Megan. "Enhanced apoptosis in melanoma cells following treatment with bortezomib (Velcade ®, PS-341) and interferon alpha (IFN-[alpha])." Connect to resource, 2007. http://hdl.handle.net/1811/28402.

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Анотація:
Thesis (Honors)--Ohio State University, 2007.
Title from first page of PDF file. Document formatted into pages: contains 25 p.; also includes graphics. Includes bibliographical references (p. 16-17). Available online via Ohio State University's Knowledge Bank.
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3

Modén, Olof. "Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity." Doctoral thesis, Uppsala universitet, Biokemi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167332.

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Glutathione transferase (GST) A2-2 is the human enzyme most efficient in catalyzing azathioprine activation. Structure-function relationships were sought explaining the higher catalytic efficiency compared to other alpha class GSTs. By screening a DNA shuffling library, five recombined segments were identified that were conserved among the most active mutants. Mutational analysis confirmed the importance of these short segments as their insertion into low-active GSTs introduced higher azathioprine activity. Besides, H-site mutagenesis led to decreased azathioprine activity when the targeted positions belonged to these conserved segments and mainly enhanced activity when other positions were targeted. Hydrophobic residues were preferred in positions 208 and 213. The prodrug azathioprine is today primarily used for maintaining remission in inflammatory bowel disease. Therapy leads to adverse effects for 30 % of the patients and genotyping of the metabolic genes involved can explain some of these incidences. Five genotypes of human A2-2 were characterized and variant A2*E had 3–4-fold higher catalytic efficiency with azathioprine, due to a proline mutated close to the H-site. Faster activation might lead to different metabolite distributions and possibly more adverse effects. Genotyping of GSTs is recommended for further studies. Molecular docking of azathioprine into a modeled structure of A2*E suggested three positions for mutagenesis. The most active mutants had small or polar residues in the mutated positions. Mutant L107G/L108D/F222H displayed a 70-fold improved catalytic efficiency with azathioprine. Determination of its structure by X-ray crystallography showed a widened H-site, suggesting that the transition state could be accommodated in a mode better suited for catalysis. The mutational analysis increased our understanding of the azathioprine activation in alpha class GSTs and highlighted A2*E as one factor possibly behind the adverse drug-effects. A successfully redesigned GST, with 200-fold enhanced catalytic efficiency towards azathioprine compared to the starting point A2*C, might find use in targeted enzyme-prodrug therapies.
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4

Robinson, Susan Clare. "Enhanced production of a recombinant, thermostable alpha-amylase in Streptomyces lividans : effects of plasmid construction and culture conditions." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393582.

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5

Rodriguez, Raul D., Evgeniya Sheremet, Tanja Deckert-Gaudig, Corinne Chaneac, Michael Hietschold, Volker Deckert, and Dietrich R. T. Zahn. "Surface- and tip-enhanced Raman spectroscopy reveals spin-waves in iron oxide nanoparticles." Universitätsbibliothek Chemnitz, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-168045.

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Nanomaterials have the remarkable characteristic of displaying physical properties different from their bulk counterparts. An additional degree of complexity and functionality arises when oxide nanoparticles interact with metallic nanostructures. In this context the Raman spectra due to plasmonic enhancement of iron oxide nanocrystals are here reported showing the activation of spin-waves. Iron oxide nanoparticles on gold and silver tips are found to display a band around 1584 cm−1 attributed to a spin-wave magnon mode. This magnon mode is not observed for nanoparticles deposited on silicon (111) or on glass substrates. Metal–nanoparticle interaction and the strongly localized electromagnetic field contribute to the appearance of this mode. The localized excitation that generates this mode is confirmed by tip-enhanced Raman spectroscopy (TERS). The appearance of the spin-waves only when the TERS tip is in close proximity to a nanocrystal edge suggests that the coupling of a localized plasmon with spin-waves arises due to broken symmetry at the nanoparticle border and the additional electric field confinement. Beyond phonon confinement effects previously reported in similar systems, this work offers significant insights on the plasmon-assisted generation and detection of spin-waves optically induced
Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
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6

Chakraborti, Amrita. "Alpha-Poly-L-Lysine As A Potential Biosorbent For Removal Of Hexavalent Chromium From Industrial Waste Water." Digital WPI, 2009. https://digitalcommons.wpi.edu/etd-theses/601.

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Remediation of heavy metals from industrial effluents and ground water sources poses a significant challenge. Hexavalent chromium is one such heavy metal, prevalent in industrial wastewaters, which has been proven to be toxic to humans and other living organisms. Most of the conventional methods available for dealing with chromium are either cost prohibitive or generate secondary effluents which are difficult to deal with. The idea of bioremediation has gained much momentum over the last few decades because of its potential low cost and minimum impact on the environment. This study explored the potential for hexavalent chromium bioremediation using a synthetic cationic biopolymer alpha-poly-l-lysine (alpha-PLL) as a biosorbent. In the present research work, equilibrium batch studies were performed in a specially designed dialysis apparatus to obtain preliminary information about the adsorption capacity of the polymer. Metal uptake by the polymer was found to be maximum when the pH of chromium solution (pH 4.6) and that of poly-lysine (pH 5.7) was not changed at the beginning of the experiment. Applying the Langmuir adsorption isotherm model showed that alpha-PLL has a maximum uptake capacity of 42.2 microgram Cr/mg alpha-PLL, and a binding constant of 1.2 microgram/mL +/- 10%. The metal uptake performance of the polymer was also evaluated in a Polymer Enhanced Diafiltration (PEDF) system. The polymer-metal complex was retained and concentrated by the PEDF set up using a tangential flow filtration membrane, while the clean filtrate flowed through. When 3.4 L of 10 mg/L chromium solution in the Cr2O72- form was processed using 300 mL of 2 gm/L PLL, the concentration of chromium in the permeate reached a maximum of 0.79 mg/L. When 30 mg/L chromium solution was used, 2 L could be processed using 300 mL of 2gm/L PLL, and 7.8 mg/L chromium could be detected in the permeate in the end.
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7

Hiavacova, Alexandra. "Enhanced adrenergic sensitivity of mesenteric veins comparied to arteries and its relation to calcium utilization and handling." Diss., Connect to online resource - MSU authorized users, 2008.

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Thesis (Ph.D.)--Michigan State University. Dept. of Pharmacology and Toxicology, 2008.
Title from PDF t.p. (viewed on July 10, 2009) Includes bibliographical references (p. 226-256). Also issued in print.
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8

Joshi, Jyotsna. "Engineering the Micro-Environment Niche of Human Bone Marrow-Derived Mesenchymal Stem Cells for Enhanced Cardiac Tissue Regeneration." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1543925924170549.

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9

LOCATELLI, LUIGI. "Expression of aVB6 integrin by Pkhd1-defective cholangiocytes links enhanced ductal secretion of Macrophage chemokines to progressive portal fibrosis in Congenital Hepatic Fibrosis." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41733.

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BACKGROUND AND AIMS: Congenital Hepatic Fibrosis (CHF) is caused by mutations in PKHD1, a gene encoding for fibrocystin, a protein of unknown function, expressed in cholangiocyte cilia and centromers. In CHF, biliary dysgenesis is accompanied by severe progressive portal fibrosis and portal hypertension. The mechanisms responsible for portal fibrosis in CHF are unclear. The αvβ6 integrin mediates local activation of TGFβ1 and is expressed by reactive cholangiocytes during cholestasis. To understand the mechanisms of fibrosis in CHF we studied the expression of αvβ6 integrin and its regulation in Pkhd1del4/del4 mice. METHODS: In Pkhd1del4/del4 mice we studied, at different ages (1-12 months): a) portal fibrosis (Sirius Red) and portal hypertension (spleen weight/body weight); b) αvβ6 mRNA and protein expression (RT-PCR, IHC); c) α-SMA and TGFβ1 mRNA expression (RT-PCR); d) portal inflammatory infiltrate (IHC for CD45 and FACS analysis of whole liver infiltrate); f) cytokines secretion from cultured monolayers of primary cholangiocytes (Luminex assay); g) cytokine effects on monocyte/macrophage proliferation (MTS assay) and migration (Boyden chamber); h) TGFβ1 and TNFα effects on β6 integrin mRNA expression by cultured cholangiocytes before and after inhibition of the TGFβ receptor type II (TGFβRII); i) TGFβ1 effects on collagen type I (COLL1) mRNA expression by cultured cholangiocytes. RESULTS: Pkhd1del4/del4 mice showed a progressive increase in αvβ6 integrin expression on biliary cyst epithelia. Expression of αvβ6 correlated with portal fibrosis (r=0.94, p<0.02) and with enrichment of a CD45+ve cell infiltrate in the portal space (r=0.97, p<0.01). Gene expression of TGFβ1 showed a similar age-dependent increase. FACS analysis showed that 50-75% of the CD45+ve cells were macrophages (CD45/CD11b/F4/80+ve). Cultured polarized Pkhd1del4/del4 cholangiocytes secreted from the basolateral side significantly increased amounts of CXCL1 and CXCL10 (p<0.05). Both cytokines were able to stimulate macrophage migration (p<0.05). Basal expression of β6 mRNA by cultured Pkhd1del4/del4 cholangiocytes (0.015±0.002 2^-dCt) was potently stimulated by the macrophage-derived cytokines TGFβ1 (0.017±0.002 2^-dCt, p<0.05) and TNFα (0.018±0.003 2^-dCt, p<0.05). Inhibition of TGFβRII completely blunted TGFβ1 (0.014±0.003 2^-dCt, p<0.05) but not TNFα effects (0.017±0.001 2^-dCt, p=ns) on β6 mRNA. COLL1 mRNA expression by cultured Pkhd1del4/del4 cholangiocytes (0.0009±0.0003 2^-dCt) was further and significantly increased after TGFβ1 stimulation (0.002±0.0005 2^-dCt, p<0.05). CONCLUSIONS: Pkhd1del4/del4 cholangiocytes possess increased basolateral secretory functions of chemokines (CXCL1, CXCL10) able to orchestrate macrophage homing to the peribiliary microenvironment. In turn, by releasing TGFβ1 and TNFα, macrophages up-regulate αvβ6 integrin in Pkhd1del4/del4 cholangiocytes. αvβ6 integrin activates latent TGFβ1, further increasing the fibrogenic properties of cholangiocytes.
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Hsu, Yu-hsiang, and 徐裕翔. "Enhanced Index Fund Performance Analysis under Multi-Factor Alpha Model." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/90225021371520196464.

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Анотація:
碩士
國立中山大學
財務管理學系研究所
98
The objective of this study is to build a complete process of quantitative stockselection model construction that combines a Multi-Factor Model and informationanalysis. Based on the quantitative stock selection model, we construct anenhanced index fund that uses the Taiwan 50 index as its benchmark. Stock prices change for a multitude of reasons, and these reasons may changeover time. In this study, we use a Multi-Factor Model and information analysis to find the relationship between stock price behavior and a factor‟s condition. Wecan use this relationship as a basis for stock selection. Moreover, the purpose of this study is to construct an enhanced index fund,hence we need to control the tracking error. We use an intuitive portfolio construction method, the original weight retention rate of the benchmark, to control tracking error. In addition, the turnover rate of a portfolio is also a significant problem as it may cause the profit of a portfolio to decreasesignificantly. In this study, we use the smoothing alpha score method to control the turnover rate of our portfolio.
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Книги з теми "Alpha-enhanced"

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K, Bhat M., and Langley Research Center, eds. Subsonic investigations of vortex interaction control for enhanced high-alpha aerodynamics of a chine forebody/delta wing configuration. Hampton, Va: National Aeronautics and Space Administration, Langley Research Center, 1992.

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Частини книг з теми "Alpha-enhanced"

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Just, M., R. Berger, D. Stürchler, H. Etlinger, M. Fernex, D. Gillessen, H. Matile, R. Pink, F. Sinigaglia, and B. Takacs. "Antibody Response to Malaria Sporozoite Vaccine Enhanced by Simultaneous Administration of Alpha-Interferon." In Travel Medicine, 262–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73772-5_49.

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2

Parashar, Aayush, Aayush Kumar Jha, and Manoj Kumar. "Analyzing a Chess Engine Based on Alpha–Beta Pruning, Enhanced with Iterative Deepening." In Expert Clouds and Applications, 691–700. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2500-9_51.

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3

Fang, Jun, Qunfang Tang, Long Liu, and Jianghua Li. "Enhanced Solvent-Stable Alpha Glycosidase Production by Bacillus licheniformis JXC-1 by Optimization of Feeding Strategies." In Lecture Notes in Electrical Engineering, 313–23. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46318-5_34.

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Kunikiyo, T., K. Sonoda, T. Yamashita, K. Ishikawa, and T. Nishimura. "3D-Simulation of an Enhanced Field-Funneling Effect on the Collection of Alpha-Particle-Generated Carriers in P− on P+ Epitaxial Substrates." In Simulation of Semiconductor Processes and Devices 1998, 400–403. Vienna: Springer Vienna, 1998. http://dx.doi.org/10.1007/978-3-7091-6827-1_99.

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J., Shanthalakshmi Revathy, Uma Maheswari N., and Sasikala S. "Enhanced BiLSTM Model for EEG Emotional Data Analysis." In Principles and Applications of Socio-Cognitive and Affective Computing, 51–63. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-6684-3843-5.ch005.

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Emotion recognition based on biological signals from the brain necessitates sophisticated signal processing and feature extraction techniques. The major purpose of this research is to use the enhanced BiLSTM (E-BiLSTM) approach to improve the effectiveness of emotion identification utilizing brain signals. The approach detects brain activity that has distinct characteristics that vary from person to person. This experiment uses an emotional EEG dataset that is publicly available on Kaggle. The data was collected using an EEG headband with four sensors (AF7, AF8, TP9, TP10), and three possible states were identified, including neutral, positive, and negative, based on cognitive behavioral studies. A big dataset is generated using statistical brainwave extraction of alpha, beta, theta, delta, and gamma, which is then scaled down to smaller datasets using the PCA feature selection technique. Overall accuracy was around 98.12%, which is higher than the present state of the art.
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"Vitamin E (D-Alpha-Tocopheryl-co-Poly(Ethylene Glycol) 1000 Succinate) Micelles-Superparamagnetic Iron Oxide Nanoparticles for Enhanced Thermotherapy and MRI." In Chemotherapeutic Engineering, 882–903. Jenny Stanford Publishing, 2014. http://dx.doi.org/10.1201/b15645-52.

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7

Motyka, Maciej, Krzysztof Kubiak, Jan Sieniawski, and Waldemar Ziaj. "Hot Plasticity of Alpha Beta Alloys." In Titanium Alloys - Towards Achieving Enhanced Properties for Diversified Applications. InTech, 2012. http://dx.doi.org/10.5772/34806.

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Stevens, Bruce R. "The Role of Glycine-Arginine-Alpha-Ketoisocaproic Acid in Sports Nutrition." In Nutrition and Enhanced Sports Performance, 637–44. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-813922-6.00054-0.

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Stevens, Bruce R. "An Overview of Glycine-Arginine-Alpha-Ketoisocaproic Acid (GAKIC) in Sports Nutrition." In Nutrition and Enhanced Sports Performance, 433–38. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-396454-0.00044-8.

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Sung, Si-Young, Beom-Suck Han, and Young-Jig Kim. "Formation of Alpha Case Mechanism on Titanium Investment Cast Parts." In Titanium Alloys - Towards Achieving Enhanced Properties for Diversified Applications. InTech, 2012. http://dx.doi.org/10.5772/35496.

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Тези доповідей конференцій з теми "Alpha-enhanced"

1

Sarangi, Saumendra, and Ashok Kumar Pradhan. "Enhanced alpha plane line protection." In 2016 19th National Power Systems Conference (NPSC). IEEE, 2016. http://dx.doi.org/10.1109/npsc.2016.7858961.

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Ito, Makoto, M. Tomita, M. Iwasaki, and R. Otani. "Sign Of Enhanced Three Alpha Matter Radius In Alpha + 12C Inelastic Scattering." In The 26th International Nuclear Physics Conference. Trieste, Italy: Sissa Medialab, 2017. http://dx.doi.org/10.22323/1.281.0210.

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Lemke, Tatjana, and Simon J. Godsill. "Enhanced Poisson sum representation for alpha-stable processes." In ICASSP 2011 - 2011 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP). IEEE, 2011. http://dx.doi.org/10.1109/icassp.2011.5947254.

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Ali, Syed Saad Azhar, Yasir Hafeez, Tajol Ashraf Bin Tajol Ariffin, Syed Hasan Adil, Hafeez Ullah Amin, and Tang Tong Boon. "Effect of Enhanced Neurofeedback Stimulus Content on Frontal Alpha Asymmetry." In 2022 IEEE 5th International Symposium in Robotics and Manufacturing Automation (ROMA). IEEE, 2022. http://dx.doi.org/10.1109/roma55875.2022.9915701.

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Georgiou, P. G., P. Tsakalides, and C. Kyriakakis. "Alpha-stable robust modeling of background noise for enhanced sound source localization." In 1999 IEEE International Conference on Acoustics, Speech, and Signal Processing. Proceedings. ICASSP99 (Cat. No.99CH36258). IEEE, 1999. http://dx.doi.org/10.1109/icassp.1999.757493.

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Whitney, Chad, Scott Pellegrin, and Chester G. Wilson. "A charge conversion nanoparticle enhanced microGeiger for alpha, beta, gamma, and neutron detection." In 2008 IEEE 21st International Conference on Micro Electro Mechanical Systems. IEEE, 2008. http://dx.doi.org/10.1109/memsys.2008.4443815.

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Lu, Y., J. Lee, C. Moneypenny, N. Mohammad, A. Aranyos, and M. L. Brantly. "Enhanced mTOR Activity in CRISPR/Cas9 Gene-Edited PIZ Alpha-1 Antitrypsin Hepatocytes." In American Thoracic Society 2022 International Conference, May 13-18, 2022 - San Francisco, CA. American Thoracic Society, 2022. http://dx.doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a4665.

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Hecht, A. A. "Search For Enhanced Alpha Preformation in the N=Z+1 Nuclei 113Ba, 109Xe, 105Te." In CAPTURE GAMMA-RAY SPECTROSCOPY AND RELATED TOPICS: 12th International Symposium. AIP, 2006. http://dx.doi.org/10.1063/1.2187884.

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Leverant, Gerald R., David L. Littlefield, R. Craig McClung, Harry R. Millwater, and Justin Y. Wu. "A Probabilistic Approach to Aircraft Turbine Rotor Material Design." In ASME 1997 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/97-gt-022.

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A probabilistic design code is being developed for high energy disks and rotors used in aircraft gas turbine engines. This code is intended to augment, not replace, the current safe-life approach to the design of these critical components. While the code will ultimately be applicable to a range of disk alloys, initial emphasis has been placed on titanium alloys containing hard alpha defects. The approach involves developing an enhanced defect distribution for hard alpha, obtaining crack initiation data for hard alpha and fatigue crack growth data for three titanium alloys, and integrating this information into a software code that is sufficiently efficient that it can be routinely used for design and life prediction.
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Hu, Chuyu, Liming Ding, Bohan Liu, Shiwei Ding, Jie Huang, Hengzhe Wang, Yuting Liu, and Mingxuan Tan. "Multi Unmanned Aerial Vehicle Area Coverage Control Based on Enhanced Alpha-Guided Grey Wolf Optimizer." In 2021 International Conference on Electronic Information Technology and Smart Agriculture (ICEITSA). IEEE, 2021. http://dx.doi.org/10.1109/iceitsa54226.2021.00084.

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Звіти організацій з теми "Alpha-enhanced"

1

Chejanovsky, Nor, Bruce D. Hammock, Eliahu Zlotkin, and Michael Gurevitz. Dually Functional Recombinant Baculovirus Expressing Both the Excitatory and Depressant Insect Selective Neurotoxins. United States Department of Agriculture, August 1993. http://dx.doi.org/10.32747/1993.7568101.bard.

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The present project is aimed to improve the insecticidal potency of baculoviruses, to American and Israeli lepidopterous pests of Spodoptera and Heliothis species, by engineering recombinant baculoviruses expressing anti-insect toxins derived from scorpion venom. Through this study were isolated recombinant Autographa california M Nucleopolyhedroviruses (AcNPVs) which expressed alpha (LqhaIT), excitatory (AaIT, LqhIT1 and LqhIT3) and depressant (LqhIT2) anti-insect neurotoxins. Bioassays on Heliothis species (Helicoverpa armigera and Heliothis virescens) were employed to assess the potency of the viruses. The recombinant viruses possessed an enhanced speed of kill compared to wild type AcNPV. Recombinant AcNPVs expressing the depressant toxins emerged as appealing improved baculoviruses. Applied combinations of alpha, excitatory and depressant toxins enhanced their insecticidal activity against blowfly and lepidopterous larvae. Moreover, combined application of recombinant AcNPVs expressing LqhaIT and AaIT possessed increased insecticidal activity compared to single applications of them. A reduced growth rate of H. virescens larvae was obtained by comparing the larvae infected with recombinant AcNPV expressing AaIT under the control of the AcNPV early ie1 to the very late p10 promoters. Through this project improved protocols and methods were developed to purify and bioassay the anti-insect toxins and their correspondent recombinant baculoviruses. A novel highly potent anti-insect toxin Aa IT5 was isolated and characterized. Finally, the impact of use of recombinant baculoviruses, expressing anti-insect scorpion neurotoxins to non-target insects, was evaluated.
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Chejanovsky, Nor, and Bruce D. Hammock. Enhancement of Baculoviruses' Insecticidal Potency by Expression of Synergistic Anti-Insect Scorpion Toxins. United States Department of Agriculture, January 1996. http://dx.doi.org/10.32747/1996.7573070.bard.

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The extensive use or non-specific, hazardous, chemical insecticides demands the development of "healthier" alternative means for pest control. Insect-specific, baculoviruses expressing anti-insect toxin genes (from mites or scorpions) demonstrated in laboratory assays and field trials enhanced insecticidal activity and provided some protection from lepidopterous larvae to agricultural plantations. To utilize recombinant baculoviruses as commercial biopesticides in row crop agriculture, further increase in their speed of kill should be achieved and the reduction in crop damage should be comparable to the levels obtained with organic insecticides (the problem). In this project we developed strategies to improve further the efficacy of recombinant baculoviruses which included: I) Synergism among baculoviruses expressing different anti-insect toxins: a) Synergism among two complementary anti-insect scorpion neurotoxins each expressed by a separate recombinant baculovirus, both regulated by the same or a different viral promoter. b) Synergism among two complementary anti-insect scorpion neurotoxins expressed by the same recombinant virus, both regulated by the same or a different viral promoter respectively. The above included two classes of pharmacologically complementary toxins: i) toxins with strictly anti-insect selectivity (excitatory and depressant); ii) toxins with preferential anti-insect activity (anti-insect alpha toxins). c) Synergism among wild type viruses, recombinant baculoviruses and chemicals (insecticides and phytochemicals) II) Identification of more potent toxins against lepidopterous pests for their expression by baculoviruses. Our approach was based on the synergistic effect displayed by the combined application of pairs of anti-insect toxins to blowfly and lepidopterous larvae that resulted in 5 fold increase in their insecticidal activity without apparent increase in their anti-mammal toxicity (toxins LqhIT2 and LqhaIT, LqhIT2 and AaIT, and LqhaIT and AaIT (1). Thus, we developed new concepts and produced a "second generation" of recombinant baculoviruses with enhanced potencies and speeds of kill comparable to classical insecticides. These achievements contribute to make these biopesticides a viable alternative to minimize the use of hazardous chemicals in pest control. Also, our project contributed new tools and model systems to advance the study of insect sodium channels.
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Gurevitz, Michael, Michael Adams, and Eliahu Zlotkin. Insect Specific Alpha Neurotoxins from Scorpion Venoms: Mode of Action and Structure-Function Relationships. United States Department of Agriculture, June 1996. http://dx.doi.org/10.32747/1996.7613029.bard.

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This study was motivated by the need to develop new means and approaches to the design of future, environmentally-safe, insecticides. Utilization of anti-insect selective toxins from scorpion venoms and clarification of the molecular basis for their specificity, are a major focus in this project and may have an applicative value. Our study concentrated on the highly insecticidal toxin, LqhaIT, and was devoted to: (I) Characterization of the neuropharmacological and electrophysiological features of this toxin. (II) Establishment of a genetic system for studying structure/activity relationships of the toxin. (III) Analysis of the insecticidal efficacy of an entomopathogenic baculovirus engineered and expressing LqhaIT. The results obtained in this project suggest that: 1) The receptor binding site of LqhaIT on insect sodium channels differs most likely from its analogous receptor site 3 on vertebrate sodium channels. 2) The effects of LqhaIT are presynaptic. Hyperexcitation at the neuromuscular results from dramatic slowing of sodium channel inactivation and enhanced peak sodium currents causes by LqhaIT. 3) The putative toxic surface of LqhaIT involves aromatic and charged amino acid residues located around the C-terminal region and five-residue-turn of the toxin (unpublished). 4) The anti-insect/anti-mammalian toxicity ratio can be altered by site-directed mutagenesis (publication 8). This effect was partly shown at the level of sodium channel function. 5) The insecticidal efficacy of AcNPV baculovirus increased to a great extent when infection was accompanied by expression of LqhaIT (publication 5).
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Ostersetzer-Biran, Oren, and Jeffrey Mower. Novel strategies to induce male sterility and restore fertility in Brassicaceae crops. United States Department of Agriculture, January 2016. http://dx.doi.org/10.32747/2016.7604267.bard.

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Abstract Mitochondria are the site of respiration and numerous other metabolic processes required for plant growth and development. Increased demands for metabolic energy are observed during different stages in the plants life cycle, but are particularly ample during germination and reproductive organ development. These activities are dependent upon the tight regulation of the expression and accumulation of various organellar proteins. Plant mitochondria contain their own genomes (mtDNA), which encode for rRNAs, tRNAs and some mitochondrial proteins. Although all mitochondria have probably evolved from a common alpha-proteobacterial ancestor, notable genomic reorganizations have occurred in the mtDNAs of different eukaryotic lineages. Plant mtDNAs are notably larger and more variable in size (ranging from 70~11,000 kbp in size) than the mrDNAs in higher animals (16~19 kbp). Another unique feature of plant mitochondria includes the presence of both circular and linear DNA fragments, which undergo intra- and intermolecular recombination. DNA-seq data indicate that such recombination events result with diverged mitochondrial genome configurations, even within a single plant species. One common plant phenotype that emerges as a consequence of altered mtDNA configuration is cytoplasmic male sterility CMS (i.e. reduced production of functional pollen). The maternally-inherited male sterility phenotype is highly valuable agriculturally. CMS forces the production of F1 hybrids, particularly in predominantly self-pollinating crops, resulting in enhanced crop growth and productivity through heterosis (i.e. hybrid vigor or outbreeding enhancement). CMS lines have been implemented in some cereal and vegetables, but most crops still lack a CMS system. This work focuses on the analysis of the molecular basis of CMS. We also aim to induce nuclear or organellar induced male-sterility in plants, and to develop a novel approach for fertility restoration. Our work focuses on Brassicaceae, a large family of flowering plants that includes Arabidopsis thaliana, a key model organism in plant sciences, as well as many crops of major economic importance (e.g., broccoli, cauliflower, cabbage, and various seeds for oil production). In spite of the genomic rearrangements in the mtDNAs of plants, the number of genes and the coding sequences are conserved among different mtDNAs in angiosperms (i.e. ~60 genes encoding different tRNAs, rRNAs, ribosomal proteins and subunits of the respiratory system). Yet, in addition to the known genes, plant mtDNAs also harbor numerous ORFs, most of which are not conserved among species and are currently of unknown function. Remarkably, and relevant to our study, CMS in plants is primarily associated with the expression of novel chimericORFs, which likely derive from recombination events within the mtDNAs. Whereas the CMS loci are localized to the mtDNAs, the factors that restore fertility (Rfs) are identified as nuclear-encoded RNA-binding proteins. Interestingly, nearly all of the Rf’s are identified as pentatricopeptide repeat (PPR) proteins, a large family of modular RNA-binding proteins that mediate several aspects of gene expression primarily in plant organelles. In this project we proposed to develop a system to test the ability of mtORFs in plants, which are closely related to known CMS factors. We will induce male fertility in various species of Brassicaceae, and test whether a down-relation in the expression of the recombinantCMS-genes restores fertility, using synthetically designed PPR proteins.
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Schwartz, Bertha, Vaclav Vetvicka, Ofer Danai, and Yitzhak Hadar. Increasing the value of mushrooms as functional foods: induction of alpha and beta glucan content via novel cultivation methods. United States Department of Agriculture, January 2015. http://dx.doi.org/10.32747/2015.7600033.bard.

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During the granting period, we performed the following projects: Firstly, we differentially measured glucan content in several pleurotus mushroom strains. Mushroom polysaccharides are edible polymers that have numerous reported biological functions; the most common effects are attributed to β-glucans. In recent years, it became apparent that the less abundant α-glucans also possess potent effects in various health conditions. In our first study, we explored several Pleurotus species for their total, β and α-glucan content. Pleurotuseryngii was found to have the highest total glucan concentrations and the highest α-glucans proportion. We also found that the stalks (stipe) of the fruit body contained higher glucan content then the caps (pileus). Since mushrooms respond markedly to changes in environmental and growth conditions, we developed cultivation methods aiming to increase the levels of α and β-glucans. Using olive mill solid waste (OMSW) from three-phase olive mills in the cultivation substrate. We were able to enrich the levels mainly of α-glucans. Maximal total glucan concentrations were enhanced up to twice when the growth substrate contained 80% of OMSW compared to no OMSW. Taking together this study demonstrate that Pleurotuseryngii can serve as a potential rich source of glucans for nutritional and medicinal applications and that glucan content in mushroom fruiting bodies can be further enriched by applying OMSW into the cultivation substrate. We then compared the immune-modulating activity of glucans extracted from P. ostreatus and P. eryngii on phagocytosis of peripheral blood neutrophils, and superoxide release from HL-60 cells. The results suggest that the anti-inflammatory properties of these glucans are partially mediated through modulation of neutrophileffector functions (P. eryngiiwas more effective). Additionally, both glucans dose-dependently competed for the anti-Dectin-1 and anti-CR3 antibody binding. We then tested the putative anti-inflammatory effects of the extracted glucans in inflammatory bowel disease (IBD) using the dextran sulfate sodium (DSS)–induced model in mice. The clinical symptoms of IBD were efficiently relieved by the treatment with two different doses of the glucan from both fungi. Glucan fractions, from either P. ostreatus or P. eryngii, markedly prevented TNF-α mediated inflammation in the DSS–induced inflamed intestine. These results suggest that there are variations in glucan preparations from different fungi in their anti-inflammatory ability. In our next study, we tested the effect of glucans on lipopolysaccharide (LPS)-induced production of TNF-α. We demonstrated that glucan extracts are more effective than mill mushroom preparations. Additionally, the effectiveness of stalk-derived glucans were slightly more pronounced than of caps. Cap and stalk glucans from mill or isolated glucan competed dose-dependently with anti-Dectin-and anti-CR-3 antibodies, indicating that they contain β-glucans recognized by these receptors. Using the dextran sulfate sodium (DSS)-inflammatory bowel disease mice model, intestinal inflammatory response to the mill preparations was measured and compared to extracted glucan fractions from caps and stalks. We found that mill and glucan extracts were very effective in downregulatingIFN-γ and MIP-2 levels and that stalk-derived preparations were more effective than from caps. The tested glucans were equally effective in regulating the number of CD14/CD16 monocytes and upregulating the levels of fecal-released IgA to almost normal levels. In conclusion, the most effective glucans in ameliorating some IBD-inflammatory associated symptoms induced by DSS treatment in mice were glucan extracts prepared from the stalk of P. eryngii. These spatial distinctions may be helpful in selecting more effective specific anti-inflammatory mushrooms-derived glucans. We additionally tested the effect of glucans on lipopolysaccharide-induced production of TNF-α, which demonstrated stalk-derived glucans were more effective than of caps-derived glucans. Isolated glucans competed with anti-Dectin-1 and anti-CR3 antibodies, indicating that they contain β-glucans recognized by these receptors. In conclusion, the most effective glucans in ameliorating IBD-associated symptoms induced by DSS treatment in mice were glucan extracts prepared from the stalk of P. eryngii grown at higher concentrations of OMSW. We conclude that these stress-induced growing conditions may be helpful in selecting more effective glucans derived from edible mushrooms. Based on the findings that we could enhance glucan content in Pleurotuseryngii following cultivation of the mushrooms on a substrate containing different concentrations of olive mill solid waste (OMSW) and that these changes are directly related to the content of OMSW in the growing substrate we tested the extracted glucans in several models. Using dextran sulfate sodium (DSS)–inflammatory bowel disease (IBD) mice model, we measured the colonic inflammatory response to the different glucan preparations. We found that the histology damaging score (HDS) resulting from DSS treatment reach a value of 11.8 ± 2.3 were efficiently downregulated by treatment with the fungal extracted glucans, glucans extracted from stalks cultivated at 20% OMSWdownregulated to a HDS value of 6.4 ± 0.5 and at 80% OMSW showed the strongest effects (5.5 ± 0.6). Similar downregulatory effects were obtained for expression of various intestinal cytokines. All tested glucans were equally effective in regulating the number of CD14/CD16 monocytes from 18.2 ± 2.7 % for DSS to 6.4 ± 2.0 for DSS +glucans extracted from stalks cultivated at 50% OMSW. We finally tested glucans extracted from Pleurotuseryngii grown on a substrate containing increasing concentrations of olive mill solid waste (OMSW) contain greater glucan concentrations as a function of OMSW content. Treatment of rat Intestinal epithelial cells (IEC-6) transiently transfected with Nf-κB fused to luciferase demonstrated that glucans extracted from P. eryngii stalks grown on 80% OMSWdownregulatedTNF-α activation. Glucans from mushrooms grown on 80% OMSW exerted the most significant reducing activity of nitric oxide production in lipopolysaccharide (LPS) treated J774A.1 murine macrophages. The isolated glucans were tested in vivo using the Dextran Sodium Sulfate (DSS) induced colitis in C57Bl/6 mice and found to reduce the histology damaging score resulting from DSS treatment. Expression of various intestinal cytokines were efficiently downregulated by treatment with the fungal extracted glucans. We conclude that the stress-induced growing conditions exerted by OMSW induces production of more effective anti-inflammatory glucans in P. eryngii stalks.
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