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Статті в журналах з теми "Allergen microarrays"
Sokolov, Pavel, Irina Evsegneeva, Alexander Karaulov, Alyona Sukhanova, and Igor Nabiev. "Allergen Microarrays and New Physical Approaches to More Sensitive and Specific Detection of Allergen-Specific Antibodies." Biosensors 14, no. 7 (July 20, 2024): 353. http://dx.doi.org/10.3390/bios14070353.
Повний текст джерелаKlimek, L., D. Vetter, L. von Bernus, and C. Thorn. "Allergen-Microarrays für die molekulare Komponentendiagnostik von Typ-I-Allergien." HNO 59, no. 10 (December 22, 2010): 988–93. http://dx.doi.org/10.1007/s00106-010-2224-5.
Повний текст джерелаRomantowski, Jan, Aleksandra Górska, Grażyna Moszkowska, Julia Kulczycka, Karolina Minkowska, Agata Rolewicz, Marita Nittner-Marszalska, and Marek Niedoszytko. "Atopy and Multisensitizations in Specific IgE Microarrays and Their Impact on Severe Asthma." Life 12, no. 10 (September 29, 2022): 1520. http://dx.doi.org/10.3390/life12101520.
Повний текст джерелаCretich, Marina, Daniela Breda, Francesco Damin, Marta Borghi, Laura Sola, Selim M. Unlu, Samuele E. Burastero, and Marcella Chiari. "Allergen microarrays on high-sensitivity silicon slides." Analytical and Bioanalytical Chemistry 398, no. 4 (August 22, 2010): 1723–33. http://dx.doi.org/10.1007/s00216-010-4077-x.
Повний текст джерелаJeon, Hyunjin, Joo Hyun Jung, Yoonji Kim, B.S., Youngeun Kwon, and Seon Tae Kim. "Allergen Microarrays forIn VitroDiagnostics of Allergies: Comparison with ImmunoCAP and AdvanSure." Annals of Laboratory Medicine 38, no. 4 (July 28, 2018): 338–47. http://dx.doi.org/10.3343/alm.2018.38.4.338.
Повний текст джерелаSzameit, Sandra, Elisabeth Weber, and Christa Noehammer. "DNA microarrays provide new options for allergen testing." Expert Review of Molecular Diagnostics 9, no. 8 (November 2009): 843–50. http://dx.doi.org/10.1586/erm.09.63.
Повний текст джерелаBaumgart, Karl. "The whether, whither or wither of allergen microarrays." Pathology 56 (February 2024): S31. http://dx.doi.org/10.1016/j.pathol.2023.12.114.
Повний текст джерелаRomantowski, Jan, Aleksandra Górska, Marek Niedoszytko, Theo Gulen, Marta Gruchała-Niedoszytko, Bogusław Nedoszytko, Magdalena Lange, et al. "A Challenge for Allergologist: Application of Allergy Diagnostic Methods in Mast Cell Disorders." International Journal of Molecular Sciences 22, no. 3 (February 1, 2021): 1454. http://dx.doi.org/10.3390/ijms22031454.
Повний текст джерелаChinnasamy, Thiruppathiraja, Loes I. Segerink, Mats Nystrand, Jesper Gantelius, and Helene Andersson Svahn. "Point-of-Care Vertical Flow Allergen Microarray Assay: Proof of Concept." Clinical Chemistry 60, no. 9 (September 1, 2014): 1209–16. http://dx.doi.org/10.1373/clinchem.2014.223230.
Повний текст джерелаCretich, Marina, Gabriele Di Carlo, Cinzia Giudici, Sven Pokoj, Iris Lauer, Stephan Scheurer, and Marcella Chiari. "Detection of allergen specific immunoglobulins by microarrays coupled to microfluidics." PROTEOMICS 9, no. 8 (April 2009): 2098–107. http://dx.doi.org/10.1002/pmic.200800651.
Повний текст джерелаДисертації з теми "Allergen microarrays"
Martinroche, Guillaume. "Quantification et caractérisation des maladies auto-immunes et allergiques à l'aide de méthodes d'apprentissage profond." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0154.
Повний текст джерелаDiagnostic tools based on artificial intelligence (AI) and capable of integrating several types of data, will be crucial in the next coming years in helping practitioners provide more personalized, precision medicine for patients. Autoimmune and allergic diseases are perfect examples of complex, multi-parametric diagnostics that could benefit from such tools. Antinuclear antibodies (ANA) on human epithelial cells (HEp-2) are important biomarkers for the screening and diagnosis of autoimmune diseases. For harmonization of biological practices and clinical management, automatic reading and classification of ANA immunofluorescence patterns for HEp-2 images according to the nomenclature recommended by the International Consensus on Antinuclear Antibody Patterns (ICAP) seems to be a growing requirement. In our study, an automatic classification system for Indirect Immunofluorescence (IIF) patterns of HEp-2 cells images was developed using a supervised learning methodology, based on a complete collection of HEp-2 cell images from Bordeaux University Hospital labelled accordingly to ICAP recommendations and local practices. The system consists of a classifier for nucleus patterns only (16 patterns and allowing recognition of up to two aspects per image) and a second classifier for cytoplasm aspects only. With this contribution to the automation of ANA in medical biology laboratories, it will enable reflex quantitative tests targeted on a few autoantibodies, ultimately facilitating efficient and accurate diagnosis of autoimmune diseases. Allergen microarrays, enable the simultaneous detection of up to 300 specific IgE antibodies and are part of a bottom-up diagnostic approach in which, on the basis of the broadest possible analysis, we then seek to determine which allergen(s) is (are) likely to explain the patient's symptoms. However, the mass of data produced by this single analysis is beyond the analytical capacity of the average user and the large number of results obtained simultaneously can mask those that are truly clinically relevant. A database of 4271 patients (Société Française d'Allergologie) was created, including allergen microarrays data and twenty-five demographic and clinical data. This database allowed the development of the first models capable of predicting patients' allergic profiles thanks to an international data challenge. The best F1-scores were around 80%. A more comprehensive tool adapted to daily practice is currently under development. Based essentially on microarrays data and a very few clinical and demographic data, it will be able to provide clinicians with a probability of molecular allergy by protein family, thus limiting diagnostic delays and the need for oral provocation tests. Diagnostic tools using so-called AI technologies are helping to improve the efficiency of current techniques, leveraging locks for repetitive, low-value-added tasks. These tools are generally poorly perceived by practitioners, who feel that they are losing their expertise, and even that they are being replaced by algorithms. This impression is particularly strong in Medical Biology, where this improvement directly affects the function of the Medical Biologist. In an attempt to better understand this, we took a closer look at the relationship of trust, if there can be one, between the practitioner and the diagnostic tool. The concepts of reliability and veracity were discussed. Thanks to a survey of medical biologists working on the analysis of aspects of HEp-2 cells, a certain reticence can be highlighted, with reasons linked to performance scores and unfamiliarity with the systems. The deployment and commitment to similar strategies in the field of biological hematology shows real interest once performance has been established. The development of two diagnostic tools for autoimmune and allergic diseases is laying the foundations for improved results and lasting integration into a more personalized, precision medicine
Ardizzoni, Andrea. "Allergome microarray for the detection of total repertoire of allergen-specific IgE human serum." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427750.
Повний текст джерелаHamed, Aljali. "Development of IgE microarray assays for classification of allergic individuals." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/37431/.
Повний текст джерелаErkers, Julia. "Towards automatic smartphone analysis for point-of-care microarray assays." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280663.
Повний текст джерелаBosco, Anthony. "Identification of novel genes associated with allergen-driven T cell activation in human atopics." University of Western Australia. School of Paediatrics and Child Health, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0023.
Повний текст джерелаWang, Xiaowei. "Development of a detection system towards a basophil-microarray for the diagnosis of allergies." Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/14187/.
Повний текст джерелаMallmann, Stefanie [Verfasser], and Ralf S. [Akademischer Betreuer] Müller. "Untersuchung der Testreaktionen in Allergen-Microarray und Intradermaltest von Hunden mit atopischer Dermatitis unter Berücksichtigung der allergisch bedingten Juckreizsymptomatik / Stefanie Mallmann ; Betreuer: Ralf S. Müller." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1216827230/34.
Повний текст джерелаPascal, i. Capdevila Mariona. "Allergenic protein and epitope recognition in food allergy: a new perspective for the molecular and clinical characterization of shellfish and lipid transfer protein allergy / Reconeixement de proteïnes i epítops al•lergènics en al•lèrgia alimentaria: una nova perspectiva per a la caracterització clínica i molecular de l’al•lèrgia al marisc i a les proteïnes de transferència de lípids." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/84070.
Повний текст джерелаActualment els mètodes diagnòstics de l'al•lèrgia alimentària no són capaços de predir la reactivitat clínica dels pacients sensibilitzats (els que tenen IgE específica davant un determinat al•lergen). Tradicionalment les proves diagnòstiques de l'al•lèrgia han utilitzat extractes complets de fonts al•lergèniques que contenen múltiples molècules, algunes al•lergèniques i altres no. Això limita enormement la precisió en el diagnòstic i la possibilitat d'identificar reaccions al•lèrgiques a diferents aliments per l'existència de reactivitats creuades. Gràcies a la caracterització dels al•lèrgens a nivell molecular, s'ha desenvolupat el concepte del Diagnòstic Basat en Components que es basa en el raonament de detectar la presència d'IgE específica per a la proteïna realment responsable de la resposta al•lèrgica i no per una mescla de molècules. Addicionalment, l'estudi del reconeixement IgE i IgG4 a nivell d'epítops amb microarrays de pèptids sintètics pot ser una eina útil per al diagnòstic, pronòstic i desenvolupament d'una teràpia per l'al•lèrgia alimentària. La hipòtesi d'aquesta tesi és que aquestes noves metodologies poden millorar el diagnòstic de l'al•lèrgia al marisc i a les proteïnes de transferència de lípids (LTP), presents en múltiples aliments vegetals. L'objectiu és doncs caracteritzar clínicament i a nivell molecular aquests dos tipus d'al lèrgies alimentàries, utilitzant aquestes noves metodologies. Respecte a l'al•lèrgia al marisc, els al lèrgens tropomiosina, proteïna sarcoplàsmica d'unió de calci i la cadena lleugera de miosina s'associen amb la reactivitat clínica a la gamba. D'altra banda, els al•lèrgens arginina quinasa i hemocianina estarien més implicats en fenòmens de reactivitat creuada amb altres artròpodes. Addicionalment, amb el microarray de pèptids sintètics s'ha pogut identificar un reconeixement diferencial d'epítops IgE i IgG4 entre pacients al•lèrgics i tolerants. Respecte a l'al•lèrgia a les LTP, els pacients pateixen reaccions amb un ampli ventall d'aliments vegetals, sent el préssec el més freqüent, amb una gran diversitat de símptomes clínics, que poden atribuir-se a al•lèrgens de diferents famílies. El diagnòstic basat en components en el format d'un microarray que inclou proteïnes al•lergèniques de diferents famílies és útil per al diagnòstic d'aquests pacients, ja que permet identificar que les úniques proteïnes responsables els símptomes clínics són les LTP, encara que els símptomes siguin molt variats i en algunes ocasions s'assemblin més als provocats per altres al•lèrgens com les profilines o els homòlegs de Bet v 1. En aquests pacients són freqüents els casos d'anafilàxia en què està involucrat un cofactor, com els antiinflamatoris no esteroïdals. La presència del fàrmac amb l'al•lergen alimentari desencadena reaccions al•lèrgiques que sense el fàrmac no es donarien o serien de menor severitat. Hem desenvolupat un model preliminar in vitro basat en el test d'activació de basòfils que ens ha permès observar in vitro l'efecte observat in vivo. En conclusió, el diagnòstic basat en components i el mapatge d'epítops són eines útils per a la caracterització de l'al•lèrgia alimentària al marisc i a les proteïnes LTP, i s'han de considerar per millorar l'eficiència del diagnòstic d'aquests dos tipus d'al•lèrgies alimentàries.
ARASI, STEFANIA. "Reliable mite-specific microarray for testing IgE antibodies in nasal secretions." Doctoral thesis, 2017. http://hdl.handle.net/11570/3121575.
Повний текст джерелаPereira, Cátia Liliana Morais. "Characterization of allergens from several tree nuts and their role in plant food allergy." Master's thesis, 2013. http://hdl.handle.net/10451/11516.
Повний текст джерелаFood allergies are a common issue in western countries. In the last decade, these diseases has increased significantly, and nowadays it is estimated that affects 2-8% of the population. Within the food allergies, plant food is the most frequent in adult population and the most part of the plant food allergens belong to protein families with defense or storage functions. Among plant food allergies there is a special interest in tree nut allergy. In the course of history, nuts have been part of the diet around the world. Tree nuts have a high nutritional value and they are very important in the human diet. However, in the developed world, the allergic reactions caused by tree nuts represent one of the first causes of food allergies in children and the first in adults. Understanding the mechanism by which a harmless protein to the organism is capable of inducing an allergic response is the basis to prevent and treat this type of disease. Until now, in food allergy, the only possible treatment is avoiding the consumption of the culprit food. Although, the existence of cross-reactivity between allergens and the specific sensitization profiles of each patient, makes it difficult to know which foods are related and which ones the patient should avoid. In order to develop safe and effective immunotherapy, it is necessary to characterize the allergens involved both at molecular and immunological level. The major allergens described in tree nuts are 7S vicilins, 11S legumins, 2S albumins, lipid transfer proteins (LTPs) and thaumatin-like proteins (TLPs). In this thesis, the allergenic molecular basis of these proteins was studied in order to try to understand the possible mechanisms that are mediating sensitization and cross-reactivity and the prevalence of these proteins in a Spanish population, with the use of protein microarrays.
As alergias alimentares são um problema comum nos países ocidentais. Na última década, estas doenças têm aumentado significativamente e actualmente é estimado que afectem 2-8% da população. Nas alergias alimentares, a alergia a alimentos vegetais é a mais frequente na população adulta e a maioria dos alergenos de alimentos vegetais pertencem a famílias de proteínas com funções de defesa e armazenamento. Entre as alergias a alimentos vegetais, há um interesse especial na alergia a frutos secos. No decurso da história, os frutos secos têm feito parte da dieta em todo o mundo. Os frutos secos têm um elevado valor nutricional e são muito importantes na dieta humana. Contudo, no mundo desenvolvido, as reacções alérgicas causadas pelos frutos secos, representam uma das primeiras causas de alergia alimentar em crianças e a primeira em adultos. Conhecer o mecanismo pelo qual uma proteína inofensiva ao organismo é capaz de induzir uma resposta alérgica, é a base para prevenir e tratar este tipo de doença. Até agora, na alergia alimentar, o único tratamento possível é evitar o consumo do alimento culpado pela alergia. Todavia, a existência de reactividade-cruzada entre alergenos e os perfis especifícos de sensibilização dos patientes, torna difícil saber que alimentos estão relacionados e quais os alimentos que o paciente deve evitar. De modo a desenvolver imunoterapia segura e eficaz é necessário caracterizar os alergenos envolvidos, tanto a nível molecular como a nível imunológico. Os alergenos maioritários descritos nos frutos secos são vicilinas 7S, leguminas 11S, albuminas 2S, proteínas de transferência de lípidos (LTPs) e proteínas similares a taumatinas (TLPs). Nesta tese, a base molecular alergénica destas proteínas foi estudada de modo a perceber os possíveis mecanismos que medeiam a sensibilização e a reactividade-cruzada e a prevalência destas proteínas numa população Espanhola, com a utilização de microarrays de proteínas
Книги з теми "Allergen microarrays"
DNA microarrays for biomedical research: Methods and protocols. New York: Humana Press, 2009.
Знайти повний текст джерелаJin, Saihong. Specific IgE profiling of 52 allergens in sensitized individuals using a new protein microarray technology. 2005.
Знайти повний текст джерелаЧастини книг з теми "Allergen microarrays"
Bacarese-Hamilton, Tito, Julian Gray, Andrea Ardizzoni, and Andrea Crisanti. "Allergen Microarrays." In Microarrays in Clinical Diagnostics, 195–207. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-923-0:195.
Повний текст джерелаKalli, Marina, Marcos J. C. Alcocer, Andrew J. Blok, and Franco H. Falcone. "Use of Humanized Fluorescent Reporter Cell Line RBL NFAT-DsRed for the Detection of Allergen-Specific IgE in Patient Sera Using Allergen Microarrays." In Basophils and Mast Cells, 155–62. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0696-4_12.
Повний текст джерелаLin, Jing, Ludmilla Bardina, and Wayne G. Shreffler. "Microarrayed Allergen Molecules for Diagnostics of Allergy." In Epitope Mapping Protocols, 259–72. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-450-6_19.
Повний текст джерелаHarwanegg, Christian, Sabine Hutter, and Reinhard Hiller. "Allergen Microarrays for the Diagnosis of Specific IgE Against Components of Cow Milk and Hen Egg in a Multiplex Biochip-Based Immunoassay." In Methods in Molecular Biology, 145–57. Totowa, NJ: Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-426-1_11.
Повний текст джерелаDe Chan, Xin, and Chuping Mu. "Sensitisation Profiles of House Dust Mite-Allergic Subjects Using an Allergen Microarray Platform." In Proceedings of the 9th IRC Conference on Science, Engineering, and Technology, 292–302. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-8369-8_29.
Повний текст джерелаJambari, Nuzul N., XiaoWei Wang, and Marcos Alcocer. "Protein Microarray-Based IgE Immunoassay for Allergy Diagnosis." In Methods in Molecular Biology, 129–37. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6925-8_10.
Повний текст джерелаOsin, Nikolay S., and Vera G. Pomelova. "Microarray Immunophosphorescence Technology for the Detection of Infectious Pathogens." In National Institute of Allergy and Infectious Diseases, NIH, 233–40. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-569-5_25.
Повний текст джерелаMartínez-Botas, Javier, and Belén de la Hoz. "IgE and IgG4 Epitope Mapping of Food Allergens with a Peptide Microarray Immunoassay." In Methods in Molecular Biology, 235–49. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3037-1_18.
Повний текст джерелаMartínez-Botas, Javier, Carlos Fernández-Lozano, Aida Vaquero-Rey, and Belén de la Hoz. "IgE and IgG4 Epitope Mapping of Food Allergens with a Peptide Microarray Immunoassay." In Methods in Molecular Biology, 219–36. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2732-7_16.
Повний текст джерелаDe Knop, K. J., C. H. Bridts, M. M. Verweij, M. M. Hagendorens, L. S. De Clerck, W. J. Stevens, and D. G. Ebo. "Component-Resolved Allergy Diagnosis by Microarray." In Advances in Clinical Chemistry, 87–101. Elsevier, 2010. http://dx.doi.org/10.1016/s0065-2423(10)50005-2.
Повний текст джерелаТези доповідей конференцій з теми "Allergen microarrays"
Vikalo, Haris, and Babak Hassibi. "Limits of performance of real-time DNA microarrays." In 2009 47th Annual Allerton Conference on Communication, Control, and Computing (Allerton). IEEE, 2009. http://dx.doi.org/10.1109/allerton.2009.5394924.
Повний текст джерелаChou, Shan-Ying, Jia-Han Wu, Shang-Ta Chou, Chia-Hui Chen, Wen-Yen Huang, Chen-Yu Chen, and Gwo-Bin Lee. "An integrated microfluidic system for automating multiplex allergy microarrays." In 2017 IEEE 12th International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). IEEE, 2017. http://dx.doi.org/10.1109/nems.2017.8017059.
Повний текст джерелаJi, Xia, Weizhong Zhang, Shao-dan Jia, Haiyan Wang, Xiao-xia Wang, Jing Li, Zhixiu Xiao, Weiyi Zhang, and Zhenmin Bao. "A Microarray Gene Expression Profile in Peripheral Blood Mononuclear Cells for Allergic Asthma in Chinese." In Biomedical Engineering. Calgary,AB,Canada: ACTAPRESS, 2012. http://dx.doi.org/10.2316/p.2012.764-007.
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