Дисертації з теми "AIPW"
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Costello, Robert. "Adaptive intelligent personalised learning (AIPL) environment." Thesis, University of Hull, 2012. http://hydra.hull.ac.uk/resources/hull:6251.
Повний текст джерелаLiang, Zhao. "Sistema multimídia para grafos de decisão no AIPC." Instituto Tecnológico de Aeronáutica, 1996. http://www.bd.bibl.ita.br/tde_busca/arquivo.php?codArquivo=1619.
Повний текст джерелаSuperti, Guilherme Bicaleto. "Nanocompósitos polímero-aluminofosfatos (silicatos) lamelares = preparação, caracterização e propriedades." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250418.
Повний текст джерелаTese (doutorado) - Universidade Estadual de Campinas, Instituto de Química
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Resumo: Este trabalho descreve a síntese de dois materiais lamelares, um silicato, a magadiita, e um aluminofosfato, a AlPO-kanemita. No primeiro caso foi feita a substituição isomórfica com alumínio e no segundo com ferro ou vanádio e também se variou os tipos de alquilaminas no espaço interlamelar, alternandose cadeias longas e curtas. A magadiita foi convertida em sua forma ácida por dois métodos diferentes: um pela troca iônica com NH4+ e outro pela troca iônica com HCl. Estudos de DRX em temperaturas crescentes demonstraram que a estabilidade térmica da magadiita não se altera após a introdução de alumínio. A acidez dos materiais foi avaliada pelo monitoramento por FTIR do CO adsorvido e verificou-se que a introdução de alumínio produz sítios de alta acidez, comparável aos zeólitos. A comparação dos dois materiais ácidos diferentes indicou que os sítios produzidos por desamoniação são mais acessíveis ao CO do que os produzidos pela troca com HCl. A AlPO-kanemita foi utilizada na preparação de compósitos poliméricos por dois métodos diferentes, por mistura no estado fundido e polimerização in situ. No primeiro caso os polímeros usados, PP e EVA, não conseguem acessar o espaço interlamelar, enquanto que no segundo caso o PS e a PA6 tem acesso, mas este depende das aminas presentes no espaço interlamelar. As massas moleculares do PS não são afetadas pela presença da AlPO-kan, mas as da PA6 são drasticamente reduzidas. A introdução dos metais de transição tem efeito na decomposição térmica dos polímeros, produzindo uma maior quantidade de um material carbonáceo quando comparada aos análogos sem metal, o que diminui a inflamabilidade do material.
Abstract: This work describes the synthesis of two layered materials, magadiite and AlPOkanemite. The first is a silicate analogous to the natural hydrated layered silicate where isomorphous substitution with aluminum was performed. AlPO-kanemite is an aluminophosphate with the same structure as the hydrated layered silicate kanemite, from the same family as magadiita. It also passed by isomorphous substitution and was also synthesized with different alkylamines at its interlayer space, alternating short and long chains. Magadiite was converted in its acid form by two different methods: ion exchange with NH4+ and themolysis or by ion exchange with HCl. The diffractograms collected in crescent temperatures show that thermal stability of magadiite does not change after introduction of aluminum. The acidity of materials was measured by monitoring the CO adsorption with FTIR and the results shows that the acidity is high, comparable to zeolites. The comparison between the two different acid materials shows that the one produced by desamoniation has acid sites more accessible to probe molecules in respect to the one produced by exchange with HCl. AlPO-kanemite was used to produce polymeric composites by two methods: melt intercalation and in situ polymerization. In the first case the polymers (PP and EVA) were not able to access the interlayer space while at the second one the PS and PA6 were found in theinterlayer space, but their concentration depends on the quantities of the amines present at the material. The molecular mass of PS was not altered by the presence of the AlPO-kan but the PA6 is drastically reduced. The introduction of the metals has effect at thermal decomposition of the polymers, producing a larger quantity of a carbonaceous material when compared to its analogous, but without metals, that diminishes the flammability of the polymer.
Doutorado
Quimica Inorganica
Doutor em Ciências
Chovítek, Jakub. "Analýza procesů ve společnosti AiP Safe s.r.o." Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-85165.
Повний текст джерелаBentama, Jilali. "Cristallogénèse et propriétés de la berlinite (AIPO) élaborée en milieu chlorhydrique." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37602899z.
Повний текст джерелаOuammou, Mohamed. "Synthèse hydrothermale de AIPO en milieux acides mixtes HCl-HSO-HPO /." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb376170368.
Повний текст джерелаToledo, Rodrigo de Almeida. "Análise do gene AIP na acromegalia familial isolada." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-25052010-174002/.
Повний текст джерелаAcromegaly is a rare disfigurating and insidious disease characterized by enlargement of hands, feet and skull bones due to excess of growth hormone (GH) secreted by a pituitary tumor (somatotropinoma). The majority of the cases with acromegaly is sporadic, however it may occur in association with inherited disorders as Multiple Endocrine Neoplasia type 1 (MEN1), Carney complex (CNC) and Isolated Familial Somatotropinoma (IFS). The genes associated with MEN1 syndrome (MEN1) and CNC (PRKAR1A) have been described more than a decade ago, however until very recently the molecular etiology of IFS remained unknown. Using a combined strategy of single nucleotide polymorphism (SNP) analysis and gene expression analysis, Vierimaa et al. (2006) described mutations in the AIP gene occurring in families with acromegaly not associated with MEN1 and CNC. In the current study, we investigated three Brazilian families with IFS and were able to describe two germline mutations in the AIP gene, confirming the role of this new gene in the predisposition to familial somatotropinoma. We revised the literature of genetic studies of isolated pituitary adenoma syndromes, which indicated a genetic heterogeneity as well as possible multigenic inheritance for these diseases. Thus, we investigated the role of several genes/loci (SSTR2, SSTR5, CDKN1B, AHR, PRKAR1A, PTTG, PROP1, MEG3, RB1 and 2p16) selected as potentially acting as phenotypic modulators in IFS. Our data indicate that AIP-mutated patients are prone to pituitary disease, however it is necessary the co-segregation of markers located at oncogenic regions to the development of the pituitary tumors and manifestation of the disease. Herein, we also present the first somatic analysis of non-pituitary tumors of AIP-mutated patients. A potential role of AIP, which is implicated in the cAMP pathway, could not be excluded in the development of an adrenocortical carcinoma.
Martins, Gesley Alex Veloso 1980. "Transformações na interface : SAPO-44." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250397.
Повний текст джерелаDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica
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Mestrado
Quimica Inorganica
Mestre em Química
Geiger, Michael [Verfasser]. "Mutational analysis of the P. falciparum ARO protein, functional analysis of its predicted binding partner AIP and identification of AIP interacting proteins / Michael Geiger." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1227582420/34.
Повний текст джерелаLeontiou, Chrysanthia. "Pituitary tumorigenesis : studies on the role of AIP and AMPK." Thesis, Queen Mary, University of London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515252.
Повний текст джерелаWilson, Amy Sue. "A saga of power, money, and sex in women's athletics: a presidents' history of the Association for Intercollegiate Athletics for Women (AIAW)." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/2661.
Повний текст джерелаRonda, Bargalló Joan Carles. "Estudio de la polimerización del fenilglicidileter con el sistema aip/znc12." Doctoral thesis, Universitat Rovira i Virgili, 1993. http://hdl.handle.net/10803/8980.
Повний текст джерелаLa microestructura dels polímers obtinguts s'ha analitzat mitjançant tècniques de RMN de 1H i 13C, determinant-ne el seu grau de tacticitat i el contingut de unions irregulars. En el cas de les fraccions solubles s'han pogut identificar i quantificar els diferents grups finals de cadena mitjançant tècniques de derivatització "in situ" i anàlisis per RMN de 19F. La naturalesa del extrems de cadena s'ha pogut relacionar amb el mecanisme de polimerització.
També s'han preparat polímers entrecreuats per copolimerització del fenilglicidiléter i diferents diglicidiléters aromàtics utilitzant l'iniciador i les condicions estudiades anteriorment. S'ha pogut determinar que el percentatge d'incorporació del comonomer a la xarxa depèn de la seva estructura. La caracterització dels materials per RMN de 13C i DSC ha permès determinar que es tracta de cadenes altament regular amb un percentatge de isotacticitat molt elevat (80%) lo que es tradueix en una elevada cristalllinitat de les mostres.
Hampson, Robert W. "Bacterial crowd control : AIP-based analogues and solonamides modulate staphylococcal virulence." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33344/.
Повний текст джерелаPatel, Gajendra. "Implementing and Evaluating MQLAIP: A Metabolism Query Language." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1289591644.
Повний текст джерелаBiasi, Vanessa. "PRODUÇÃO DE SALAME TIPO ITALIANO ATRAVÉS DE CURA NATURAL COM EXTRATOS DE AIPO E ACELGA." Universidade Federal de Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/5693.
Повний текст джерелаA indústria cárnea está sempre atenta às exigências dos consumidores, e na busca por produtos saudáveis, uma vez que consumidores estão mudando seus hábitos alimentares. O nitrito de sódio é usualmente utilizado como conservante químico e está relacionado com doenças como o câncer, por isso, produtos elaborados sem a adição desse agente de cura, ou naturalmente curados, estão tendo uma ampla atenção. A partir de extratos vegetais e uma cultura starter nitrato-redutora, podem-se obter produtos cárneos similares aos curados convencionalmente. O objetivo deste trabalho foi desenvolver e avaliar a qualidade de salames tipo Italiano produzidos por cura natural, utilizando extratos de aipo e acelga como fontes de nitrato, adicionados ou não de culturas starters nitrato-redutoras. Avaliaram-se seis tratamentos (T1 - 0,8% de extrato de aipo e cultura starter pré-incubada; T2 - 0,8% de extrato de aipo sem incubação da cultura starter; T3 - 1,2% de extrato de aipo e cultura starter pré-incubada; T4 - 0,3% de extrato de aipo; T5 - 0,3% de extrato de aipo e cultura starter pré-incubada e T6 - 0,3% de extrato de acelga e cultura starter pré-incubada) e um controle (nitrato de sódio e eritorbato de sódio). Realizaram-se análises físico-químicas (pH, composição centesimal, atividade de água, nitrito e nitrato de sódio, cor e TBA (teste do ácido tiobarbitúrico), análises microbiológicas (coliformes a 45ºC, Staphylococcus coagulase positiva, Salmonella sp., clostrídios sulfito-redutores e bactérias lácticas) e análise sensorial. Após 30, 60 e 90 dias de armazenamento, foram avaliadas a estabilidade à oxidação lipídica (TBA) e os parâmetros de cor dos salames. Todos os tratamentos apresentaram desenvolvimento de cor típica de produto curado e os resultados físico-químicos e microbiológicos atenderam aos padrões da Legislação Brasileira. Sensorialmente todos os tratamentos foram considerados inferiores ao controle, porém, aceitáveis para os tratamentos T4, T5 e T6. O atributo mais prejudicado foi o sabor, seguido do odor. Durante o período de armazenamento, a cor dos tratamentos manteve-se de maneira semelhante à do controle, porém, avaliando os valores de a*, não apresentou estabilidade nos tratamentos com as menores concentrações de extratos, e estes valores foram superiores nos tratamentos onde houve pré-incubação da cultura starter. Entretanto, para a formação da mesma, não é necessário o tempo de pré-incubação da cultura starter. No final do armazenamento, o tratamento controle apresentou maiores valores de TBA, mostrando a eficiência dos extratos vegetais como antioxidantes.
Lecoq, Anne-Lise. "Implication d'AIP (Aryl hydrocarbon receptor Interacting Protein) dans la tumorigenèse des adénomes hypophysaires." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS028.
Повний текст джерелаIn this work, we investigated the effects of AIP deficiency in vivo on somatotroph cells, both at the secretory and proliferative levels and explored in vitro the signaling pathways potentially involved in AIP-dependent pituitary tumorigenesis. Phenotype analyzes of Aip+/- mice, especially of GH pulsatility, show that, unlike humans, mutant mice do not develop gigantism nor GH hypersecretion and present with a much lower penetrance of pituitary adenomas than initially described. In vitro studies in fibroblasts of AIP-mutation positive patients with pituitary adenomas and in somatolactotroph GH3 cells demonstrate that AIP mutations alter AhR (Aryl hydrocarbon Receptor) transcriptional activity and modify the cAMP pathway. Finally, GPR101 mutations, recently reported in patients with sporadic acromegaly, have also been identified in a small portion of patients with sporadic non-somatotroph pituitary adenomas, without any association with AIP mutations. This research work defines the consequences of AIP mutations on somatotroph cell function and AhR transcriptional activity. The role of cAMP signaling in AIP-related pituitary tumorigenesis will be further evaluated in a new transgenic mouse model
Rowles, Matthew Ryan. "The structural nature of aluminosilicate inorganic polymers: a macro to nanoscale study." Thesis, Curtin University, 2004. http://hdl.handle.net/20.500.11937/1641.
Повний текст джерелаChai, Nan. "Micro-raman study of iodine nanowires confined inside the channels of AIPO[subscript 4]-11 single crystals /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?PHYS%202008%20CHAI.
Повний текст джерелаScudder, Christopher John. "AIP- and organohalogenated-chemical-associated acromegaly : a little help from a feline friend?" Thesis, Royal Veterinary College (University of London), 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766327.
Повний текст джерелаRabe, Angela C. "Effectiveness of a Serpentine Inlet Duct Flow Control Scheme at Design and Off-Design Simulated Flight Conditions." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/28653.
Повний текст джерелаPh. D.
Haouas, Mohamed. "Etude rmn de la synthese hydrothermale des aluminophosphates microporeux oxyfluores : aipo#4 cj2, ulm-3 et ulm-4." Université Louis Pasteur (Strasbourg) (1971-2008), 1999. http://www.theses.fr/1999STR13015.
Повний текст джерелаJensen, Rasmus O. "Functional analysis of the group specific interactions between AIP and AgrC in Staphylococcus aureus." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/10686/.
Повний текст джерелаFoltran, Renata Kikuchi. "Estudo molecular dos genes GNAS, PTTG, AIP, CDKN1B e MEG3 em adenomas hipofisários esporádicos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-02052016-142707/.
Повний текст джерелаBACKGROUND: Pituitary adenomas are benign tumors that account for about 15% of intracranial tumors. Mostly occurs sporadically. Molecular studies of these adenomas identified genetic abnormalities that may have a role in tumorigenesis. Some of these genes have been described as the oncogenes GNAS and PTTG and tumor suppressor genes AIP, CDKN1B and MEG3. OBJECTIVE: perform a molecular study of genes related in tumorigenesis to evaluate presence of mutations in GNAS, AIP and CDKN1B genes and gene expression analysis of CDKN1B, PTTG and MEG3 genes in apparently sporadic adenomas, correlating with the clinical and laboratory data from patients treated at the Endocrinology service of HCFMUSP.SUBJECTS AND METHODS: 96 apparently sporadic adenomas was included: 41 somatotropinomas, 27 corticotropinomas, 21 clinically nonfunctioning pituitary adenomas (NFPA) and seven prolactinomas. Retrospective evaluation of clinical and laboratory data from diagnosis. After histological analysis by hematoxylin-eosin staining, it was performed immunohistochemical analysis of Ki -67 and p53 proteins and molecular analysis of genomic DNA and RNA extracted from tumor tissue. Mutational analysis of coding regions of AIP and CDKN1B and hotspots exons 8 and 9 of GNAS was performed by PCR and automatic sequencing. Relative quantification of mRNA CDKN1B, MEG3 and PTTG was evaluated by 2-??Ct method using Real Time PCR. RESULTS: Presence of somatic mutations on GNAS gene (gsp+) in 14,5% of pituitary adenomas. There were no clinical and laboratorial differences between gsp+ and gsp- somatotropinomas. Variants with pathogenic potencial were not identified in AIP and CDKN1B genes. Imunohistochemical analysis showed mean of 1,32% (0,9-4,5) for Ki-67 and mean of 1,04% (1,0-1,8) for p53. Gene expression of CDKN1B presented a mean of 1,12 ± 0,74 (0,1-3,1) with lower expression in corticotropinomas. Gene expression of PTTG presented a mean of 2,49 ± 3,10 (0,2-19,0) with higher expression in corticotropinomas. Gene expression of MEG3 presented a mean of 0,95 ± 1,38 (0,0-8,8) with lower expression in NFPA. Three cluster patterns in the levels of mRNA expression of genes CDKN1B, PTTG and MEG3 were identified: cluster A = CDKN1B >= 1,85/ PTTG >= 1,25/ MEG3 >= 0,65 observed in 100% of corticotropinomas; cluster B= CDKN1B >= 0,95/ PTTG >= 2,25/ MEG3 >= 0,65 observed only in somatotropinomas (32%) and cluster C= CDKN1B >= 0,95/ PTTG >= 1,25/ MEG3 >= 0,05 observed in most of NFPA (73%). CONCLUSIONS: Most of the adenomas showed Ki -67 index lower than 3%. In accordance with this finding, immunohistochemistry for p53 was not statistically significant. The activating mutation in the Gs? protein (gsp+) was the most common mutation in sporadic pituitary adenomas, particularly in somatotropinomas. Variants with pathogenic potential have not been identified in the AIP and CDKN1B gene therefore seems to be a rare event in sporadic adenomas. Increased gene expression of PTTG was primarily identified in corticotropinomas. However, it was not predictive of adenoma subtype. The gene expression of CDKN1B was decreased in most corticotropinomas and normal in most somatotropinomas and NFPA. The gene expression of MEG3 was decreased in most of NFPA and corticotropinomas, and normal in most somatotropinomas. In hierarchical cluster analysis was identified three patterns of gene expression that correlated with pituitary adenoma subtype
Ribeiro, Mariana Wilson. "A importância das Agências de Internacionalização para as PME : o caso da AIP - CCI." Master's thesis, Instituto Superior de Economia e Gestão, 2012. http://hdl.handle.net/10400.5/5908.
Повний текст джерелаAs agências de internacionalização desempenham cada vez mais um papel muito importante no percurso das pequenas e médias empresas. Estas agências contribuem para a vantagem competitiva das pequenas e médias empresas formando-as e preparando-as para a sua entrada em mercados internacionais. Este trabalho pretende demonstrar a importância das agências de internacionalização através do exemplo prático de uma agência, a Associação Industrial Portuguesa – Câmara de Comércio e Indústria, das conclusões de autores especializados na temática da internacionalização de empresas e de estudos que caracterizam o perfil exportador das pequenas e médias empresas em Portugal. Após a análise do caso de estudo, artigos e dados estatísticos apresentados, este trabalho permite perceber de que forma as agências de internacionalização podem ter um contributo importante junto de pequenas e médias empresas que determinem internacionalizarem-se através destas agências, bem como as mais valias inerentes à tomada deste passo por parte de uma empresa.
The internationalization support agencies play an increasingly important role in the path of small and medium enterprises. These agencies contribute to the competitive advantage of small and medium enterprises teaching and preparing them to entry into new international markets. This paper discusses the importance of internationalization support agencies through the practical example of an agency, the Portuguese Industrial Association - Chamber of Commerce and Industry. Through bibliographies by authors specialized in the issue of the internationalization of firms and statistics that characterize the profile of exporting small and medium enterprises in Portugal. After analyzing the case study, articles and statistical data presented, this work allows us to see how the internationalization support agencies may have an important contribution throughout the small and medium enterprises that determined to internationalize themselves through these, as well as the gains inherent by taking this step.
Fernandes, Mário Marques. "Validação do instrumento de Análise da Impressão e do Impacto do Prejuízo Estético (AIPE) para uso em Odontologia Legal." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/23/23153/tde-25022016-165121/.
Повний текст джерелаIn the last decades, the elevated number of victims of traffic accidents, urban violence, sports-related trauma, occupational injuries, and professional-related errors increased the concern with the expert aspect, whether in the criminal or civil context, because of the sequelae associated with these injuries and trauma, also to the maxillofacial region. In this sense, this study aimed to translate into Brazilian Portuguese and culturally adapt for use in Brazil the Spanish instrument called Analysis of Aesthetic Damage Impression and Impact (AIPE) proposed by Cobo Plana (2010), and to validate the instrument among dentists working in forensic dentistry. After translation and cultural adaptation, fake scars (moulage) were placed on the maxillofacial region of two models, a male and a female. Dentists specializing in forensic dentistry were selected to make the assessments. These students used the instrument, which consists of four tables, on a sequence of ten randomized images, showing models with and without facial scars. The intraclass correlation coefficient measured observer reliability to verify instrument validity. In general the method was satisfactory for one scar and excellent for two scars of the three repeated scars. Regarding intertester error, descriptive analysis of the results showed a variation coefficient of the scores of 40.12% when all the coefficients were considered, demonstrating that the scores were relatively homogeneous. The four tables translated into Brazilian Portuguese and culturally adapted for Brazil have the potential to increase the objectivity of aesthetic damage assessment.
Cox, Spencer L. "User Datagram Protocol with Congestion Control." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1250.pdf.
Повний текст джерелаRowles, Matthew Ryan. "The structural nature of aluminosilicate inorganic polymers: a macro to nanoscale study." Curtin University of Technology, Department of Applied Physics, 2004. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=16061.
Повний текст джерелаMicroscopy showed that the microstructure variations correlated with the compressive strength. In general, AIPs with low compressive strengths exhibited an inhomogeneous two-phase microstructure; grain and matrix. The grain phase consisted of undissolved metakaolinite, whilst the matrix was the fully formed inorganic polymer. AIPs with high compressive strengths exhibited a microstructure that was more homogeneous than the samples with low compressive strength. The compressive strength of the AIPs depended on both the chemical composition and the level of residual MK present in the microstructure. EDS microanalysis showed that the composition of the two phases was significantly different, and that the differences depended on the overall composition of the AIP. EDS results also demonstrated that the impurity elements present in the metakaolinite were affected by the polymerisation process. Soluble elements such as Ca and Mg were found primarily in the matrix, indicating that they had leached out of the metakaolinite grains, whereas insoluble elements such as Fe and Ti were found primarily in the grains. The nanoscale structure of the AIPs was examined by solid-state nuclear magnetic resonance (NMR) and x-ray scattering (XRS). The NMR measurements revealed that the average coordination of Si varied according to the composition of the AIP, whereas the coordination of Al was constant. Na is present in the network in both hydrated and non-hydrated forms. It is postulated that the variation in the Si coordination can be explained by the formation of Si-O-Na bonds with Na forming an ionic bond with 0 in the polymer network. Radial distribution function (RDF) analysis of the XRS patterns revealed little difference in the structure of the different AIPs beyond ~2.5 Å.
Unfortunately, the data were of insufficient resolution to allow for a full evaluation of the differences in the Si-O and Al-O bonds between different AIPs. However, the trends present in the shape and position of the RDF peak corresponding to the Si-O and Al-O bonds do follow the composition of the AIP. It has been shown that a variety of experimental techniques can be used in concert to obtain information on the structural nature of AIPs. To this end, it has been found that the compressive strength of AIPs can be optimised, and that the microstructure of the AIPs changes systematically with variations in the compressive strength. An improved model for the structure of AIPs has also been proposed.
Courbard, Jean-Rémy. "Régulation de la signalisation du récepteur à l'EGF [Epidermal Growth Factor] par les E3 ligases Cbl-c & AIP4/Itch." Aix-Marseille 2, 2004. http://www.theses.fr/2004AIX20658.
Повний текст джерелаIn order to stop the signal at the plasma membrane, TKR are internalised in clathrin vesicles. In the endosomes, they are internalised in endosomal vesicles, and then they are addressed to lysosome compartment to be degraded. These two negative regulation critical steps are controlled by the ubiquitin molecule which serves as recruitment signal for regulation proteins controlling the internalisation processes. Cbl E3 ligases, and notably c-Cbl, play a central role in EGFR downregulation inducting EGFR ubiquitination at the plasma membrane and in the endosomes. The third Cbl family member, Cbl-c was cloned in the laboratory. As the others Cbl members, Cbl-c is able to ubiquitinate EGFR. We identified a new Cbl-c partner: a HECT E3 ligase, AIP4/Itch. We showed that the association could contribute to the EGFR ubiquitination and downregulation. But we do not know yet how and when the association takes place
González, Fernando. "Analysis of QoS using IEEE 802.11e for WLANs." Thesis, Linköping University, Department of Electrical Engineering, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2114.
Повний текст джерелаIEEE 802.11 [1]is the standard that has emerged as a prevailing technology for the wireless local area networks. It can be considered the wireless version of Ethernet, which supports best-effortservice. IEEE is developing a new standard called 802.11e to be able to provide quality of service (QoS) in WLANs. Two possible methods have been proposed in [3]in order to improve the performance of service differentiation in the MAC layer. They are called PCWA (Practical Contention Window Adjustment) and AIPM (Adaptive Initiative Polling Machine). In this thesis, I will analyse both methods and propose new ideas to improve their performance, simulating the ideas concerning PCWA. Simulations show better general performance, especially for highest priorities flows, although the behaviour of the lowest priority one is reduced.
Pietra, Stefano. "Characterization of New Players in Planar Polarity Establishment in Arabidopsis." Doctoral thesis, Umeå universitet, Institutionen för fysiologisk botanik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-87838.
Повний текст джерелаSamordning av polaritet och differentiering av celler inom ett vävnadslager är avgörande för utvecklingen av multicellulära organismer. Rothår och bladhår hos Arabidopsis thaliana utgör modellsystem för att studera signalvägar som kontrollerar planpolaritet och specifikation av cellers öde hos växter. En koncentrationsgradient av växthormonet auxin ger en instruktiv signal som koordinerar polär hopsättning av signalkomplex vid plasmamembranet i rotepidermisceller; dock är kunskapen om ytterligare aktörer och hur cytoskelettets aktörer påverkar cellpolaritet innan rothår bildas begränsad. Vad gäller differentieringen av epidermala cellers öde kontrolleras dessa genom ett väl karakteriserat nätverk av transkriptionsfaktorer som överför positionssignaler och cell-till-cell kommunikation till vävnadsomfattande mönsterbildning. Fortfarande hittas dock nya komponenter som interagerar med signalvägarna för mönsterbildning, vilket ger nya insikter om dess förbindelser med diverse utvecklingsprocesser. Denna avhandling presenterar genen SABRE (SAB) som en ny aktör i etableringen av planpolaritet och mönsterbildning av rotepidermis. SAB är ett stort protein som har sekvenslikhet med proteiner som finns i alla eukaryoter och det påverkar planpolaritet, orientering av celldelning och kortikala mikrotubler. Genetisk interaktion med genen för det mikrotubuli-associerade proteinet CLASP stärker ytterligare inblandningen av SAB i organiserandet av mikrotubler och antyder att denna gen har en roll i organiserandet av cytoskelettet. Slående är att SAB även interagerar genetiskt med ACTIN7 (ACT7) och att både ACT7 och dess modulator ACTIN-INTERACTING PROTEIN1-2 (AIP1-2) bidrar till planpolaritet vid positionering av rothår. Cellfils-specifikt uttryck av AIP1-2 beror på den epidermala mönsterbildande genen WEREWOLF (WER), vilket påvisar ett samband mellan organisationen av aktin, planpolaritet och specifikationen av cellers öde. SAB fungerar även i mönsterbildning av rotens epidermis och stabiliserar förvärvet av cellöde uppströms av den centrala signalvägen för mönsterbildning. Dessa resultat visar på nya roller för SAB i planpolaritet och mönsterbildning av epidermis och indikerar att organiseringen av mikrotubler och aktin-cytoskelettet är viktiga både för etablerandet av planpolaritet och för specificeringen av cellers öde.
Igreja, Susanna. "Novel genetic causes of sporadic and familial pituitary adenomas : Assessment of CDKN1B and AIP gene mutations." Thesis, Queen Mary, University of London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528977.
Повний текст джерелаThoendel, Matthew James. "Synthesis of the accessory gene regulator autoinducing peptide in Staphylococcus aureus." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/2999.
Повний текст джерелаPlyley, Dale E. "The AIAW vs. the NCAA, a struggle for power to govern women's athletics in American institutions of higher education, 1972-1982." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ28637.pdf.
Повний текст джерелаWei, Xin. "Analysis of Quality of Service of Wireless LAN for IEEE 802.11e." Thesis, Linköping University, Department of Electrical Engineering, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2154.
Повний текст джерелаNowadays Wireless LAN is playing a more and more important role in network systems. After 1999, in which the IEEE organization published its Wireless Local Network standard 802.11[1], many people saw the advantages of the standard but also the lack of support for multimedia streaming. A lot of research work has been done on the proposed IEEE 802.11e standard draft during the past 4 years. It is supposed to be able to fully support Quality of Service. The final version will be published early in 2004. In my thesis, I propose two possible methods to improve the performance of service differentiation in the MAC layer. The first one is calledPCWA (Practical Contention Window Adjustment). It is a method with which the station finds a best size of its contention window when running the EDCF (Enhanced Distributed Coordination Function) access method. It helps to improve the total system throughput, the jitter and the delay of traffics with different priorities. The second method is called AIPM (Adaptive Initiative Polling Machine). It uses the polling mechanism for differential service, intelligently arranging the polling time to reduce the delay as much as possible, achieving large improvement in performance. This method significantly increases the total system throughput, while the delay and jitter of the traffics are very much small in comparison to EDCF.
Silva, Daniele Pena da. "Interesses profissionais em jovens de ensino médio: um estudo comparativo entre a AIP e o BBT-Br." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/59/59137/tde-09022015-181020/.
Повний текст джерелаCareer Guidance and Career Processes aim to assist people in reflecting on their own life plans and decisions related to career. Applied in a dynamic and integrative perspective, psychological assessment instruments can contribute to clarify inclinations and dispositions to career choice for those who seek help for such undertaking. Among several psychological variables that can influence occupational choices, the professional interests stand out in this study, measured by two instruments: the Assessment of Professional Interests (AIP) and the Test of pictures of Occupations (Berufsbilder Test, BBT-Br). This research aims to describe the structures of professional interests of students in regular secondary and technical education schools by gender and school of origin. To assess the internal consistency (reliability) of the chosen instrument, the results have been correlated to the AIP BBT-Br. The research sample consisted of 231 participants, aged from 16 to 55 years; 75 (32.5%) male and 156 (67.5%) female patients; 121 (52.4%) and 110 (47.6%) from technical schools and regular high schools, respectively. Students in technical schools were distributed in courses on administration, secretarial, machine design, mechatronics, electrical engineering, and buildings. The results indicated significant differences in career choices depending on the sex of the participants. This agrees with similar studies already reported in the area, indicating the existence of patterns of differentiated choices between men and women. Also, for the school of origin, it was found significant differences between students from technical and regular schools only in the male sample group. Regarding to internal consistency of the AIP (Cronbach\'s alpha), values ranged from 0.529 to 0.746 , which can be considered reasonable rates; for the BBT -Br were found internal consistency values between 0.418 to 0.753, indicators also classified as reasonable levels of reliability. With respect to the analysis of correlation coefficients (Pearson correlation) between the AIP and the BBT, several significant correlations ( 0.30) were obtained in both female and male sample groups. Therefore, it is noted for the convergence of the results of both instruments; on the internal consistency of the AIP, it indicates the need for improving the instrument. Finally, we point out the importance of expanding studies to evaluate the characteristics of students from technical high schools
Melo, Flavia Marques de. "Avaliação de mutações nos genes supressores de tumor MEN1 e AIP em prolactinomas associados a síndromes familiais." Universidade Federal de Minas Gerais, 2012. http://hdl.handle.net/1843/BUOS-97CJFH.
Повний текст джерелаAdenomas de hipófise são neoplasias benignas que ocorrem a partir da expansão de células específicas da adenohipófise. Estes tumores compreendem 10 a 15% de todos os tumores intracranianos. Os mecanismos patogênicos destes podem ocorrer em função de alterações genéticas ou epigenéticas, que resultam na desregulação do ciclo celular, alteração da sinalização intracelular ou perda de fatores supressores de tumor. O prolactinoma é o adenoma hipofisário mais frequente e pode causar infertilidade. No entanto, casos familiais da doença são raros e pouco entendidos. Portanto, a proposta deste trabalho foi realizar caracterizações moleculares de duas famílias com histórico de prolactinoma: a família 1, identificada como prolactinoma familial isolado, e a família 2, um caso de neoplasia endócrina múltipla tipo 1 (MEN1). Para isso, foram pesquisadas mutações em dois genes supressores de tumor, AIP e MEN1. DNA genômico foi extraído de integrantes hígidos e afetados das duas fam ílias estudadas. O sequenciamento foi realizado para os 9 exons codificantes de MEN1, e os 6 exons de AIP. Nenhuma variante foi detectada no gene MEN1 nas amostras testadas de ambas as famílias. Também não foram detectadas mutações em AIP nos pacientes da família 1, mas o paciente portador de MEN1 apresentou a variante p.R16H. De acordo com os resultados desse trabalho, não há correlações entre mutações nos genes MEN1 e AIP e o desenvolvimento de prolactinoma na família 1. O papel da variante p.R16H na progressão de MEN1 no paciente da família 2 necessita de maiores investigações.
Valles, Jose Antonio. "Acute interstitial pneumonia in feedlot cattle." Thesis, Kansas State University, 2013. http://hdl.handle.net/2097/15619.
Повний текст джерелаDepartment of Clinical Sciences
Daniel U. Thomson
Acute Interstitial Pneumonia (AIP) is a costly issue that affects feedlot cattle, especially during hot and dry summers. Research has yet to elucidate the exact etiology of AIP; therefore this study was conducted to determine possible factors that contribute to AIP in feedlot cattle. During the summer of 2011 in a 55,000 head feedyard in southwest Kansas, animals exhibiting clinical signs of AIP were selected for ante-mortem examination and data collection. The animal population within the feedlot consisted of 75% heifers and 25% steers. Approximately 50% of the animal population was black hided animals. Ante-mortem data consisted of rumen gas cap measurement for NH3 and H2S, rumen pH, serum chemistry, rectal temperature, and body weight. Post-mortem cases with and without ante-mortem evaluations were also selected for an additional examination. Postmortem examination included similar data as ante-mortem examination with addition of visual and histological examination of lung tissue. There were 31 ante-mortem cases of clinical AIP with the following observations (mean ± SD): rectal temperature 105.3 ± 0.7 °F, weight 1098 ± 123 lbs., H2S 136 ± 133.3 ppm, and rumen pH 6.4 ± 0.5. Twenty-five healthy cohorts were selected from identical pens to serve as controls. Observations from control animals were: rectal temperature 103.7 ± 1.1 °F, weight 1113 ± 133.3lbs, H2S 269.8 ± 311.6 ppm and rumen pH 6.2 ± 0.6. A total of 61 post-mortem cases with a preliminary diagnosis of AIP were analyzed and displayed the following values: H2S 1279.7 ± 1569 ppm, and rumen pH 6.3 ± 0.36. Fifty-three of these postmortem cases had diffuse, focal and /or patchy AIP confirmed by histology.
Renaud, Denis. "Caractérisation du propulseur PEGASES : diagnostics du filtre magnétique et du faisceau : optimisation de la géométrie." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2018/document.
Повний текст джерелаThe PEGASES ion thruster differs from standard electric propulsion technologies through its use of electronegative gases, such as SF₆, as a propellant. Its operation relies on the trapping of electrons using a magnetic field and the creation of a plasma dominated by positive and negative ions. These ions are alternately accelerated to produce thrust, and later undergo a recombination to ensure beam neutrality. This thruster eliminates the need for an electron-producing neutralizer, which is a standard feature in other sources such as the Hall thruster. This thesis is divided into three parts. The first describes the development and implementation of a new EXB probe for the study of the ion beam properties, the identification of the beam chemical composition and the verification of the presence of negative and positive ion species. The second part concerns the design and application of a new laser photodetachment diagnostic for the measurement of the negative ion fraction. Lastly, a new ion-ion thruster with a circular geometry, known as AIPE, has been designed, constructed and successfully tested. This prototype eliminates the plasma asymmetry present in PEGASES and reveals the importance of the magnetic filter to source operation
Kohanowich, Kurt M. "Logistics support for Commercial Items and Non-Developmental Items case study : the P-3C Anti-Surface Warfare Improvement Program (AIP)." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1998. http://handle.dtic.mil/100.2/ADA356611.
Повний текст джерела"September 1998." Thesis advisor(s): David F. Matthews, Jane Feitler. Includes bibliographical references (p. 67-70). Also available online.
Moraes, Michelle Buscarilli de. "Análise do status somático dos genes MEN1, AIP e p27Kip1 em tumores de pacientes com neoplasia endócrina múltipla tipo 1." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-11072012-112431/.
Повний текст джерелаApproximately 80% of cases with multiple endocrine neoplasia type 1 (MEN1) harbor a germline mutation in the tumor suppressor gene MEN1, which predisposes these patients to tumors comprehending the parathyroid and pituitary glands, endocrine pancreas and others non-endocrine tumors. The tumorigenesis of the more than 20 different types of tumors already described in the MEN1 syndrome occurs due to a MEN1 germline mutation associated with a second mutational event in the cells of these tissues, leading to loss of heterozygosity (LOH) of the MEN1 gene locus (11q13) and therefore inactivation of tumor suppressor protein encoded by this gene, MENIN protein. Recently, germline mutations in other genes have been described in cases with MEN1 without any detectable mutations in the MEN1 gene. These novel genes (CDKN1A, CDKN1B, CDNK2B and CDKN2C) encode proteins involved in the control of the cell cycle (p21, p27, p15 and p18), called cyclin dependent kinases inhibitors. Another gene, called AIP, which encodes a chaperon protein with the same name, was recently described associated with MEN1 phenotypes. These data described a role for these novel genes in the germline level, however whether they are inactivated in tumors of patients with MEN1 mutation is so far not clarified. The present study investigated for the first time, the somatic status of p27KIP1 gene mutation in patients with MEN1 and identified four possible loss of heterozygosity (LOH) in tumors of the parathyroid and pancreas, suggesting that in addition 11q13-LOH, MEN1 tumors may suffer rare loss additional tumor suppressor gene p27KIP1. These are the first evidence in the literature of a process of tumorigenesis in MEN1 multi-step, involving three genetic events: 1-MEN1germlinemutation; 2-11q13LOH; 3-Loss of somatic tumor suppressor gene p27Kip1/CDKN1B
Caimari, Palou Francisca. "Pituitary disease in the context of unusual situations." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/669456.
Повний текст джерелаCushing’s syndrome (CS) and familial isolated pituitary adenomas (FIPA) are rare diseases, present in less than 1-9 cases/100.000 of the general population. Pregnancy in women with a diagnosis of CS is an extremely rare event and its diagnosis and treatment are a real medical challenge. The difficulties in diagnosis are related to the resemblance of symptoms of CS and those of pregnancy, and to the complex interpretation of the screening tests. Importantly, the etiology of CS in pregnancy differs from non-pregnant status as the adrenal origin is the most frequent in up to 60% of the cases. There is no consensus as to the most effective treatment in these circumstances in terms of improving maternal and fetal outcomes, as there are no studies comparing the different modalities of treatment for CS in pregnancy. On the other hand, clinically relevant pituitary tumors during childhood are also a rare medical condition. These cases can be related to germline mutations predisposing to pituitary tumorigenesis, often in a familial setting, including classical tumor predisposition syndromes such as multiple endocrine neoplasia type 1 or 4 syndromes, as well as FIPA, a heterogeneous condition of patients with unknown genetic cause, patients with mutation in AIP and X-linked acrogigantism, often leading to pituitary gigantism. This thesis is composed of two studies. The first study aimed to investigate whether the etiology of CS in pregnancy determined a different impact on the fetal/newborn and maternal outcomes. A systematic review of cases published in the literature was performed from January 1952 to April 2015 including the words “Cushing AND pregnancy”. Two-hundred and sixty-three pregnancies with active CS during pregnancy and with a history of CS, but treated and cured hypercortisolism at the time of gestation, were included in the study. Adrenal adenoma was the main cause of active CS during pregnancy (44.1%). Women with active CS had more pregnancy-related complications like gestational diabetes mellitus, gestational hypertension and preeclampsia, than those with cured disease. The proportion of fetal loss in active CS was higher than in cured CS (23.7 vs 8.5%, p=0.021), as well as global fetal morbidity (33.6 vs 4.9%, p<0.001). Patients with active CS, especially in pregnancy-induced CS, experienced more problems in pregnancy and had the worst fetal prognosis in comparison to other causes. Diagnosis of CS during pregnancy was also associated with worse overall fetal morbimortality. Finally, both medical treatment and surgery during pregnancy appeared to be protective in avoiding fetal loss. The second study aimed to develop and validate a reliable risk category system for AIP mutations in patients with pituitary adenomas (PA). An international cohort of 2227 subjects were consecutively recruited between 2007 and 2016, including patients with PAs (familial and sporadic) and their relatives. 1405 patients had a pituitary tumor, of which 43% had a positive family history, 55.5% had somatotropinomas and 81.5% presented with macroadenoma. Overall, 134 patients had an AIP mutation (9.5%). Four independent predictors for the presence of an AIP mutation were identified and used to develop the risk category system: age of onset, family history, growth hormone excess tumor type and large tumor size. The risk category system classified patients into low-risk (<5% risk of AIP mutation), moderate- (5-19%) and high-risk (>20% risk). Excellent discrimination (c-statistic=0.87) and internal validation were achieved, indicating it can reliably estimate the individual risk of carrying an AIP mutation for a given patient.
Isulv, Alexandra, and Jonatan Lage. "Aeronautical Information - And the Process behind It." Thesis, Linköpings universitet, Kommunikations- och transportsystem, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104022.
Повний текст джерелаAlazmi, Huda Salem. "The Development of GIS Instructional Model to Facilitate Authentic Intellectual Work in Secondary Social Studies Classrooms in Kuwait." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/97906.
Повний текст джерелаDoctor of Philosophy
Geographical Information Systems (GIS) are software-based technologies which simplify the gathering, storing and manipulation of spatially-related data in ways which allow users to visually represent complex geographic phenomena more easily, bringing greater understanding for the world around us. As a result, the integration of GIS technology into social studies classroom practices has assisted student learning and achievement. However, despite the value which GIS possesses, few schools have integrated this technology so far. A significant reason for this limitation is the lack of clear guidelines or models which demonstrate how to employ this technology in the classroom. To help address the problem, this study developed a GIS Instructional Model for Kuwaiti social studies teachers to facilitate student authentic intellectual work, i.e. the student's demonstration of their deeper understanding for the knowledge and skills they are learning. The study employed a design and developmental research methodology, comprised of five major phases, (i) selection of model components and theoretical foundation, (ii) analysis and development, (iii) formative feedback, (iv) revision, and (v) usability evaluation. Phase one involved the selection of the study's theoretical foundation. In phase two, following a comprehensive review of relevant academic literature and, in combination with personal experience, the researcher developed a preliminary GIS Instructional Model. Two expert reviewers evaluated the model in phase three, delivering their opinions by completing an online survey and taking part in follow-up interviews. This feedback was analyzed in phase four, leading to revisions in the GIS Instructional Model to improve its quality for supporting student learning. In the final phase, six Kuwaiti expert reviewers assessed the newly-updated model to determine what barriers it might face regarding its implementation in the Kuwaiti educational system. They completed an online survey as part of this process and provided possible solutions to address these perceived obstacles. This step-by-step procedure helped to validate the model. The overall result was the development of a ready-to-implement teaching model, with all necessary educational materials and instructions, for employing GIS technology in Kuwaiti social studies classrooms to support student authentic intellectual work. In addition, recommendations were provided for Kuwaiti educational policymakers and stakeholders to help overcome perceived obstacles that may hinder model implementation; suggestions for future research are also included.
Sheng, Wei-An [Verfasser], Hansjörg [Akademischer Betreuer] Scherberger, Alexander [Gutachter] Gail, and Florentin [Gutachter] Wörgötter. "Representation of individual finger movements in macaque areas AIP, F5 and M1 / Wei-An Sheng ; Gutachter: Alexander Gail, Florentin Wörgötter ; Betreuer: Hansjörg Scherberger." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1186968273/34.
Повний текст джерелаSchaffelhofer, Stefan [Verfasser], Hansjörg [Akademischer Betreuer] Scherberger, and Stefan [Akademischer Betreuer] Treue. "From vision to action: Hand representations in macaque grasping areas AIP, F5, and M1 / Stefan Schaffelhofer. Gutachter: Hansjörg Scherberger ; Stefan Treue. Betreuer: Hansjörg Scherberger." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/106440409X/34.
Повний текст джерелаKalaki, Rafael Bordonal. "Implementação de planos estratégicos em associações de interesse privado do agronegócio: principais desafios e uma proposta de método." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/96/96132/tde-08022019-165302/.
Повний текст джерелаPrivate interest associations (PIAs) have great importance as agents of collective actions, and in agribusiness they have fundamental functions for the proper functioning of an agribusiness chain. With the changes in the competitive environment, PIAs also had to restructure. Understanding and anticipating the dynamics of the global agribusiness environment will be increasingly critical to the success of an organization, in this sense, strategic planning is an essential tool to face change and increase opportunities. As important as exercise of thinking and planning, it is to execute the plan; therefore, the successful implementation of a plan is critical. Organizations spend financial resources and time to build a strategic plan that aims to be effective and get returns to the organization, but not always the expected returns are achieved, largely by the discontinuation of the plans or by the wrong choice of implementation strategy. In the literature are found several tools and methods for building strategic plans, however, regarding the implementation process and plan management, little is found with depth, especially in relation to implementation in PIAs. In this context, the general objective of this thesis is to raise the main problems faced by PIAs on implementation of strategic plans and propose a method for strategic plan implementing the in agribusiness PIAs. In order to reach the desired results, the desk research, grounded theory and five case studies with agribusiness PIAs that practice strategic planning were used. As a result, this thesis has presented a survey of the main points of difficulties and failure factors that a PIA may face in strategic plan implementation, as well as a survey of success factors that can be adopted by the PIAs in the strategic plans implementation. The research also was proposed a method for strategic plans implementing in agribusiness AIPs. The proposed is a theoretical-empirical method, wich may be useful fot he business and academic community. The relevance of this study is in the unprecedented proposal to discuss in the academic sphere, the problems and success factors faced by agribusiness PIAs in strategic plans implementation, besides proposing a method that aims to assist the PIAs in this process. In addition to the academic contributions, this study intends to have managerial implications for improving the success of the strategic plan implementation in agribusiness PIAs, seeking to increase their competitiveness
村川, 正男. "寄生虫感染魚類に由来するアポトーシス誘導分子AIPの分子作用機構". 京都大学 (Kyoto University), 2001. http://hdl.handle.net/2433/150894.
Повний текст джерелаGarcia, Érica Correia. "Efeito da cabergolina no adenoma hipofisário clinicamente não funcionante e correlação dos polimorfismos do gene do receptor do glicocorticoide e da proteína AIP nos corticotropinomas." reponame:Repositório Institucional da UnB, 2017. http://repositorio.unb.br/handle/10482/24884.
Повний текст джерелаTexto parcialmente liberado pelo autor. Conteúdo restrito: Capítulos 3. Tumor Hipofisário Secretor de ACTH e 4. Conclusão.
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A abordagem das doenças hipotálamo-hipofisárias representa um desafio na endocrinologia. Em geral, as doenças que envolvem a hipófise possuem elevada morbidade, taxas de mortalidade acima do observado na população geral e propedêutica diagnóstica e terapêutica complexas. Uma melhor compreensão dos mecanismos envolvidos na patogênese dessas condições certamente é um caminho para o desenvolvimento de alternativas terapêuticas nesse contexto. No presente estudo, investigamos a eficácia de uma modalidade de tratamento medicamentoso para o adenoma clinicamente não funcionante (ACNF), e analisamos aspectos genéticos em correlação com a tumorigênese e fenótipo, em pacientes portadores de corticotropinomas - doença de Cushing (DC). Na investigação do ACNF, avaliamos a eficácia da cabergolina (2mg/semana) no tratamento desses tumores em um acompanhamento de curto prazo (6 meses). Dezenove pacientes (10 homens e 9 mulheres) foram submetidos ao tratamento no Hospital Universitário de Brasília (HUB). Onze desses tinham realizado cirurgia transesfenoidal previamente e 8 deles não tinham sido submetidos a nenhum procedimento. Mais da metade (57,89%) dos pacientes tiveram progressão tumoral no último ano antes do início da cabergolina. Após o uso dessa medicação por 6 meses, apenas 21% apresentaram aumento do volume tumoral. Houve redução do volume inicial do tumor em 78,5% dos pacientes (redução significativa, acima de 25%, em 31,5% e redução de pelo menos 10% em 47% dos pacientes). O estudo da doença de Cushing incluiu 53 pacientes acompanhados no HUB, que foram investigados para 2 genes (do receptor de glicocorticoide - GR e da proteína de ligação ao receptor do hidrocarboneto de arila - AIP). Há evidências de que polimorfismos no gene GR levam à alteração do funcionamento normal do eixo hipotálamo-hipófise-adrenal (HHA) e à vulnerabilidade para distúrbios psiquiátricos na população geral. Como a doença de Cushing é amplamente associada aos diversos transtornos psiquiátricos, e cursa essencialmente com hipersecreção crônica de glicocorticoides, uma melhor compreensão dos mecanismos genéticos envolvidos na expressão fenotípica dessa doença pode contribuir, no futuro, para uma melhor condução desses pacientes. Foram investigados os polimorfismos rs6190 (R23K) e rs41423247 (BclI). O polimorfismo R53K do gene GR não foi encontrado entre os 53 pacientes, entretanto o polimorfismo BclI foi encontrado em alta frequência nessa amostra. O grupo com distúrbio psiquiátrico apresentou BclI em homozigose significativamente maior que o grupo controle (45% e 8%, respectivamente). Mutações no gene AIP, por sua vez, foram demonstradas como causadoras do adenoma hipofisário familiar isolado (FIPA), e têm sido descritas em pacientes com tumores hipofisários esporádicos, principalmente nos tumores secretores de hormônio do crescimento ou de prolactina. Na doença de Cushing, a prevalência de mutações nesse gene é baixa. Avaliamos o genótipo do AIP em pacientes portadores de corticotropinomas. Em consonância com os dados da literatura, nenhuma mutação foi encontrada na nossa amostra. Entretanto, o que despertou interesse foi a alta prevalência do polimorfismo localizado no exon 1 desse gene (rs139459091, variante proteica R9Q) e a presença da variante K201*. Futuras investigações incluindo um número maior de pacientes, bem como a realização de estudos funcionais, são necessárias para a compreensão da real importância desses achados. A investigação do uso cabergolina nos ACNF foi animadora (redução tumoral com essa medicação), bem como o estudo da correlação dos aspectos genéticos na expressão fenotípica dos adenomas hipofisários (o polimorfismo do gene GR, BclI em homozigose, foi estatisticamente mais significativo na DC). Já em relação à pesquisa sobre a tumorigênese na DC, mais estudos são necessários para estabelecer sua relação com o gene da proteína AIP.
The approach of hypothalamic-pituitary diseases represents a challenge in endocrinology. In general, pathologies involving the pituitary have high morbidity, mortality rates above what is observed in the general population, and complex diagnostic and therapeutic. A better understanding of the mechanisms involved in the pathogenesis of these conditions is certainly a pathway for the development of therapeutic alternatives in this context. In the present study, we investigated the efficacy of a drug treatment modality for nonfunctioning pituitary adenoma (NFPA), and analyzed genetic aspects in correlation with tumorigenesis and phenotype in patients with corticotropinomas - Cushing's disease (CD). In the investigation of the NFPA, we evaluated the efficacy of cabergoline (2mg / week) in the treatment of these tumors in a short-term follow-up (6 months). Nineteen patients (10 men and 9 women) underwent treatment at the Hospital Universitário de Brasília (HUB). Eleven of these had undergone transsphenoidal surgery (TSS) previously and 8 of them had undergone no procedure. 57.89% of the patients had tumor progression in the last year before the onset of cabergoline. After the use of this medication for 6 months, only 21% presented increased tumor volume. There was a reduction of the initial tumor volume in 78.5% of patients (significant reduction, above 25%, in 31.5% and reduction of at least 10% in 47% of patients). The Cushing's disease study included 53 patients matched in HUB and 2 genes were investigated (the glucocorticoid receptor gene - GR and the aryl hydrocarbon receptor binding protein gene - AIP). There is evidence that polymorphisms in the GR gene lead to vulnerability to psychiatric disorders in the general population. As Cushing's disease is extensively associated with various psychiatric disorders, and its signs and symptoms are a consequence of the chronic hypersecretion of glucocorticoids, a better understanding of the genetic mechanisms involved in the phenotypic expression of this disease may contribute, in the future, to a better conduction of these patients. The polymorphisms rs6190 (R23K) and rs41423247 (BclI) were investigated. The R23K polymorphism of the GR gene was not found among the 53 patients, however the BclI polymorphism was found at high frequency in this sample. The group with psychiatric disorder presented BclI in homozygosis significantly higher than the control group (45% and 8%, respectively). Mutations in the AIP gene have been shown to cause familial isolated pituitary adenoma (FIPA), and have been described in patients with sporadic pituitary tumors, especially in growth hormone or prolactin secreting tumors. In Cushing's disease, the prevalence of mutations in this gene is low. We evaluated the AIP genotype in patients with corticotropinomas. In agreement with the literature data, no mutation was found in our sample. However, what aroused interest was the high prevalence of the polymorphism located in exon 1 of this gene (rs139459091, variant protein R9Q) and the presence of the variant K201 *. Future investigations including a larger number of patients, as well as conducting functional studies, are necessary to understand the real importance of these findings. The investigation of cabergoline use in ACNF was encouraging (tumor reduction with this medication), as well as the study of genetic aspects in the phenotypic expression of pituitary adenomas (BclI homozygous polymorphism of the GR gene was statistically more significant in DC). Regarding the research on tumorigenesis in DC, more studies are needed to establish its relationship with the AIP protein gene.
Veld, Rijk in 't [Verfasser], Hansjörg [Akademischer Betreuer] [Gutachter] Scherberger, and Alexander [Gutachter] Gail. "Neural coding of grasp force planning and control in macaque areas AIP, F5, and M1 / Rijk in 't Veld ; Gutachter: Hansjörg Scherberger, Alexander Gail ; Betreuer: Hansjörg Scherberger." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/1117219453/34.
Повний текст джерелаBa, Awa. "Les Fonctions reconnues à l'agriculture intra et périurbaine (AIPU) dans le contexte dakarois ; caractérisation, analyse et diagnostic de durabilité de cette agriculture en vue de son intégration dans le projet urbain de Dakar (Sénégal)." Phd thesis, AgroParisTech, 2007. http://pastel.archives-ouvertes.fr/pastel-00004646.
Повний текст джерела