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Добірка наукової літератури з теми "Adipose-derived mesenchymal stem cell"

Автор: Grafiati

Опубліковано: 11 березня 2023

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Статті в журналах з теми "Adipose-derived mesenchymal stem cell"

Zahran F, Zahran F., El-Deen IM El-Deen IM, Hamed S. Hamed S, and EL-Shenawy A. EL-Shenawy A. "Characterization of Adipogenic Differentiation of Mesenchymal Stem Cell Derived from Mice Adipose Tissue." Indian Journal of Applied Research 3, no. 7 (October 1, 2011): 18–22. http://dx.doi.org/10.15373/2249555x/july2013/7.

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Kawata, Yumiko, Eiji Ikami, Junya Nojima, Shoichiro Kokabu, Tetsuya Yoda, and Tsuyoshi Sato. "Effect of Adipose Tissue-Derived Mesenchymal Stem Cells on Irradiated Bone Marrow-Derived Mesenchymal Stem Cells." Journal of Bone Biology and Osteoporosis 4, no. 1 (November 15, 2018): 94–98. http://dx.doi.org/10.18314/jbo.v4i1.1230.

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Adipose-derived Mesenchymal stem cells have emerged as an attractive alternative source of cell therapy. While radiation therapy is an important application for head and neck cancer, the effect of adipose-derived mesenchymal stem cells on irradiated bone marrow-derived Mesenchymal stem cells is still unclear. Herein, we explored how clinical total radiation dose affect gene expression related with differentiation on murine bone marrow-derived mesenchymal stem cells and how murine adipose-derived mesenchymal stem cells affect irradiated murine bone marrow-derived mesenchymal stem cells. The clinical total radiation dose upregulates osterix mRNA expression. Moreover, adiposederived mesenchymal stem cells dramatically promoted the upregulation of osterix mRNA expression whereas inhibited NFATc1 mRNA expression. Taken as a whole, irradiated bone marrow-derived mesenchymal stem cells co-cultured with adipose-derived mesenchymal stem cells may exhibit osteogenic property.

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An, JH, KB Kim, SC Kwon, HJ Kim, MO Ryu, YI Oh, JO Ahn, and HY Youn. "Canine adipose tissue-derived mesenchymal stem cell therapy in a dog with renal Fanconi syndrome." Veterinární Medicína 67, No. 4 (February 16, 2022): 206–11. http://dx.doi.org/10.17221/213/2020-vetmed.

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Renal Fanconi syndrome (RFS) affects the proximal tubular resorption in the nephrons. This causes excessive loss of key solutes through the urine. In a canine patient, we successfully managed the renal tubular acidosis and proteinuria caused by RFS via transplantation of canine adipose tissue-derived mesenchymal stem cells (cAT-MSCs). cAT-MSCs were administered ten times at intervals of 2–4 weeks. The post-therapy check-up revealed that the cAT-MSC treatment improved the renal tubular acidosis and proteinuria. Hence, a cAT-MSC transplant may be considered as an adjuvant therapy in veterinary medicine to initiate and maintain relief of RFS-induced acidosis and proteinuria.

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Gerth, David J., and Seth R. Thaller. "Adipose-Derived Mesenchymal Stem Cells." Journal of Craniofacial Surgery 30, no. 3 (May 2019): 636–38. http://dx.doi.org/10.1097/scs.0000000000005336.

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Bunnell, Bruce A. "Adipose Tissue-Derived Mesenchymal Stem Cells." Cells 10, no. 12 (December 6, 2021): 3433. http://dx.doi.org/10.3390/cells10123433.

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Анотація:

The long-held belief about adipose tissue was that it was relatively inert in terms of biological activity. It was believed that its primary role was energy storage; however, that was shattered with the discovery of adipokines. Scientists interested in regenerative medicine then reported that adipose tissue is rich in adult stromal/stem cells. Following these initial reports, adipose stem cells (ASCs) rapidly garnered interest for use as potential cellular therapies. The primary advantages of ASCs compared to other mesenchymal stem cells (MSCs) include the abundance of the tissue source for isolation, the ease of methodologies for tissue collection and cell isolation, and their therapeutic potential. Studies conducted both in vitro and in vivo have demonstrated that ASCs are multipotent, possessing the ability to differentiate into cells of mesodermal origins, including adipocytes, chondrocytes, osteoblast and others. Moreover, ASCs produce a broad array of cytokines, growth factors, nucleic acids (miRNAs), and other macromolecules into the surrounding milieu by secretion or in the context of microvesicles. The secretome of ASCs has been shown to alter tissue biology, stimulate tissue-resident stem cells, change immune cell activity, and mediate therapeutic outcomes. The quality of ASCs is subject to donor-to-donor variation driven by age, body mass index, disease status and possibly gender and ethnicity. This review discusses adipose stromal/stem cell action mechanisms and their potential utility as cellular therapeutics.

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Franco, GG, BW Minto, LP Coelho, PF Malard, ER Carvalho, FYK Kawamoto, BM Alcantara, and LGGG Dias. "Autologous adipose-derived mesenchymal stem cells and hydroxyapatite for bone defect in rabbits." Veterinární Medicína 67, No. 1 (November 29, 2021): 38–45. http://dx.doi.org/10.17221/85/2020-vetmed.

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This study aims to evaluate the effect of autologous adipose-derived mesenchymal stem cells (AAD-MSC), with and without synthetic absorbable hydroxyapatite (HAP-91), on the bone regeneration in rabbits. Thirty-four female white New Zealand rabbits were submitted to a 10 mm distal diaphyseal radius ostectomy, divided into 3 experimental groups according to the treatment established. The bone gap was filled with 0.15 ml of a 0.9% saline solution containing two million AAD-MSC (G1), or AAD-MSC associated with HAP-91 (G2). The control group (CG) received only 0.15 ml of the 0.9% saline solution. Radiographs were made post-operatively, and after 15, 30, 45 and 90 days. Fifty percent of the samples were submitted to a histological examination at 45 days and the remaining ones at 90 days post-operatively. Radiographically, the periosteal reaction, bone callus volume and bone bridge quality were superior in G2 (P < 0.05). Histologically, the bone repair was faster and more efficient in G1 at 45 days (P < 0.05). In conclusion, AAD-MSC improved the regeneration on the experimentally induced bone defects in rabbits; however, the use of hydroxyapatite requires caution given the granulomatous reaction produced in the species.

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Alió del Barrio, Jorge L., Ana De la Mata, María P. De Miguel, Francisco Arnalich-Montiel, Teresa Nieto-Miguel, Mona El Zarif, Marta Cadenas-Martín, et al. "Corneal Regeneration Using Adipose-Derived Mesenchymal Stem Cells." Cells 11, no. 16 (August 16, 2022): 2549. http://dx.doi.org/10.3390/cells11162549.

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Adipose-derived stem cells are a subtype of mesenchymal stem cell that offers the important advantage of being easily obtained (in an autologous manner) from low invasive procedures, rendering a high number of multipotent stem cells with the potential to differentiate into several cellular lineages, to show immunomodulatory properties, and to promote tissue regeneration by a paracrine action through the secretion of extracellular vesicles containing trophic factors. This secretome is currently being investigated as a potential source for a cell-free based regenerative therapy for human tissues, which would significantly reduce the involved costs, risks and law regulations, allowing for a broader application in real clinical practice. In the current article, we will review the existing preclinical and human clinical evidence regarding the use of such adipose-derived mesenchymal stem cells for the regeneration of the three main layers of the human cornea: the epithelium (derived from the surface ectoderm), the stroma (derived from the neural crest mesenchyme), and the endothelium (derived from the neural crest cells).

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Ko, M., TH Kim, Y. Kim, D. Kim, JO Ahn, BJ Kang, S. Choi, I. Park, JH Choi, and JY Chung. "Improvement of systemic lupus erythematosus in dogs with canine adipose-derived stem cells." Veterinární Medicína 64, No. 10 (October 26, 2019): 462–66. http://dx.doi.org/10.17221/46/2019-vetmed.

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A 6-year-old, intact female, Maltese presented with limited movement of the hind limbs and intermittent pruritus for three months. The patient was diagnosed with systemic lupus erythematosus. Conventional immunosuppressive therapy was attempted for 70 days; however, the patient still suffered from life-threatening pancreatitis and hepatopathy. Therefore, we tried canine adipose-derived mesenchymal stem cells for immunomodulation and liver protection. After 6-months of the stem cell therapy, the patient’s walking and hepatopathy improved. These findings indicate that stem cell therapy may be another option for systemic lupus erythematosus in dogs.

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Lee, Rebecca, Nicoletta Del Papa, Martin Introna, Charles F. Reese, Marina Zemskova, Michael Bonner, Gustavo Carmen-Lopez, Kristi Helke, Stanley Hoffman, and Elena Tourkina. "Adipose-derived mesenchymal stromal/stem cells in systemic sclerosis: Alterations in function and beneficial effect on lung fibrosis are regulated by caveolin-1." Journal of Scleroderma and Related Disorders 4, no. 2 (January 25, 2019): 127–36. http://dx.doi.org/10.1177/2397198318821510.

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The potential value of mesenchymal stromal/stem cell therapy in treating skin fibrosis in scleroderma (systemic sclerosis) and of the caveolin-1 scaffolding domain peptide in treating lung, skin, and heart fibrosis is known. To understand how these observations may relate to differences between mesenchymal stromal/stem cells from healthy subjects and subjects with fibrosis, we have characterized the fibrogenic and adipogenic potential of adipose-derived mesenchymal stromal/stem cells from systemic sclerosis patients, from mice with fibrotic lung and skin disease induced by systemic bleomycin treatment, and from healthy controls. Early passage systemic sclerosis adipose-derived mesenchymal stromal/stem cells have a profibrotic/anti-adipogenic phenotype compared to healthy adipose-derived mesenchymal stromal/stem cells (low caveolin-1, high α-smooth muscle actin, high HSP47, low pAKT, low capacity for adipogenic differentiation). This phenotype is mimicked by treating healthy adipose-derived mesenchymal stromal/stem cells with transforming growth factor beta or caveolin-1 small interfering RNA and is reversed in systemic sclerosis adipose-derived mesenchymal stromal/stem cells by treatment with caveolin-1 scaffolding domain peptide, but not scrambled caveolin-1 scaffolding domain peptide. Similar results were obtained with adipose-derived mesenchymal stromal/stem cells from systemic sclerosis patients and from bleomycin-treated mice, indicating the central role of caveolin-1 in mesenchymal stromal/stem cell differentiation in fibrotic disease.

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Hodgkinson, Tom, Francis Wignall, Judith A. Hoyland, and Stephen M. Richardson. "High BMPR2 expression leads to enhanced SMAD1/5/8 signalling and GDF6 responsiveness in human adipose-derived stem cells: implications for stem cell therapies for intervertebral disc degeneration." Journal of Tissue Engineering 11 (January 2020): 204173142091933. http://dx.doi.org/10.1177/2041731420919334.

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Stem cell–based regenerative strategies are promising for intervertebral disc degeneration. Stimulation of bone-marrow- and adipose-derived multipotent stem cells with recombinant human growth differentiation factor 6 (rhGDF6) promotes anabolic nucleus pulposus like phenotypes. In comparison to mesenchymal stem cells, adipose-derived multipotent stem cells exhibit greater NP-marker gene expression and proteoglycan-rich matrix production. To understand these response differences, we investigated bone morphogenetic protein receptor profiles in donor-matched human mesenchymal stem cells and adipose-derived multipotent stem cells, determined differences in rhGDF6 signalling and their importance in NP-like differentiation between cell populations. Bone morphogenetic protein receptor expression in mesenchymal stem cells and adipose-derived multipotent stem cells revealed elevated and less variable expression of BMPR2 in adipose-derived multipotent stem cells, which corresponded with increased downstream pathway activation (SMAD1/5/8, ERK1/2). Inhibitor studies demonstrated SMAD1/5/8 signalling was required for rhGDF6-induced nucleus-pulposus-like adipose-derived multipotent stem cell differentiation, while ERK1/2 contributed significantly to critical nucleus pulposus gene expression, aggrecan and type II collagen production. These data inform cell regenerative therapeutic choices for intervertebral disc degeneration regeneration and identify further potential optimisation targets.

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Більше джерел

Дисертації з теми "Adipose-derived mesenchymal stem cell"

ANGHILERI, Elena. "Adipose-derived mesenchymal stem cells: neuronal differentiation potential and neuroprotective action." Doctoral thesis, Università degli Studi di Verona, 2010. http://hdl.handle.net/11562/343866.

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Le cellule mesenchimali staminali adulte derivate dal tessuto adipose (Adipose Stem Cell, ASC) rappresentano, nell’ambito della terapia cellulare, un’alternativa valida agli altri tipi di cellule staminali (Stem Cell, SC) poichè si possono ottenere in ampia quantità dal tessuto adipose, possono esser facilmente coltivate in laboratorio ed espanse. Abbiamo investigato in vitro il potenziale differenziativo delle ASC in senso neuronale usando due tipi di approcci: un trattamento chimico ed un protocollo prolungato in 2 fasi, che include la formazione di sfere e il sequenziale trattamento BDNF (brain-derived neurotrophic factor) e acido retinoico (retinoic acid, RA). Dopo 30 giorni, circa il 57% di ASC mostra caratteristiche morfologiche, fenotipiche ed elettrofisiologiche suggestive di una precoce differenziazione neuronale. Infatti, le ASC assumono una forma allungata, con 2-3 processi citoplasmatici, esprimono selettivamente nestina e le molecule neuronali, fra cui il recettore di GABA-A e tirosina idrossilasi, in assenza di markers gliali. Le cellule differenziate esibiscono un potenziale di membrana negativo (−60 mV), correnti di potassio rettificanti ritardate e correnti TTX sensibili, elementi tipici della cellula neuronale; tuttavia non son in grado di generare un potenziale d’azione. Considerando la bassa efficienza del trattamento e la incompleta differenziazione neuronale, abbiamo quindi valutato se le ASC esercitino una funzione neuro-protettiva. Usando il modello di neuroblastoma esposto a H2O2 in vitro, dimostriamo che le ASC aumentano la vitalità cellulare (confrontate con i fibroblasti) e proteggono dall’apoptosi. Un possibile meccanismo coinvolto potrebbe esser la secrezione di BDNF, come riportato per le SC mesenchimali (Mesenchymal SC, MSC) derivate da midollo osseo; infatti il medium condizionato di ASC contiene alti livelli di BDNF. Oltre a esibire neuro-protezione, fattori solubili secreti da ASC promuovono la crescita del neurite, un meccanismo aggiuntivo che può favorire la neurorigenerazione. Alla luce di questi dati e dell’azione immunosoppressiva delle ASC recentemente da noi dimostrato (Constantin et al, 2009), le ASC possono essere una utile sorgente di MSC per il trattamento delle malattie neurodegenerative.
Adult mesenchymal stem cells derived from adipose tissue (ASC) offer significant practical advantages over other types of stem cells (SC) for potential clinical applications, since they can be obtained from adult adipose tissue in large amounts, can be easily cultured and expanded with a very low risk for development of malignancies. We investigated in vitro the neuronal differentiation potential of human ASC with a chemical protocol and a prolonged two-step protocol, which included sphere formation and sequential culture in brain-derived neurotrophic factor (BDNF) and retinoic acid (RA). After 30 days, about 57% ASC show morphological, immunocytochemical and electrophysiological evidence of initial neuronal differentiation. In fact, ASC display elongated shape with protrusion of two or three cellular processes, selectively express nestin and neuronal molecules (including GABA-A receptor and tyroxine hydroxilase) in the absence of glial phenotypic markers. Differentiated cells show negative membrane potential (−60 mV), delayed rectifier potassium currents and TTX-sensitive sodium currents, but they are unable to generate action potential. Considering the low efficacy and the not-fully mature neuronal differentiation, we evaluated if ASC display a neuroprotective effect. Using the H2O2-stressed neuroblastoma model in vitro, we show that ASC increase cell availability (compared to fibroblasts) and protect against apoptosis. A possible mechanism involved could be the secretion of BDNF, as reported for human BM-MSC: in this regard, we indeed find high levels of BDNF in ASCcondition medium. In addition to exert neuroprotection, soluble factors secreted by ASC promote neurite outgrowth, an additional mechanism that may favor neuroregeneration. In view of these results and their immunosuppressive action (Constantin et al, 2009), ASC may be a ready source of adult MSC to treat neurodegenerative diseases.

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Brown, Alice Clare. "Generating hair follicle inductive dermal papillae cells from adipose derived mesenchymal stem cells." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29596.

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Current management options for cutaneous burn wounds, including split thickness skin grafts and cultured epithelial autografts, generate an epithelial barrier which lacks a dermal layer and skin adnexae including hair follicles and sebaceous glands. This results in a loss of pliability and contractures that cause functional and cosmetic impairment. Embryological hair follicle morphogenesis results from a complex series of mesenchymal-epithelial interactions and to date a method of generating de novo folliculogenesis from human cells has yet to be accomplished. Existing models rely on combining 'inductive’ dermal and 'receptive’ epithelial components and placing them within a suitable model. Epithelial cells are easily obtainable from skin biopsies therefore obtaining sufficient quantities of 'trichogenic’ dermal cells remains the most significant challenge of this approach. The main aim of this project is to contribute to the achievement of de novo folliculogenesis by generating dermal papillae (DP) like-spheroids using adipose derived mesenchymal stem cells (ASCs) that, when combined with responsive epithelial cells, would be capable of inducing hair follicle formation. ASCs were directed towards a hair follicle DP-like fate by culture using the hanging drop method and exposure to Wnt, mimicking signalling and mesenchymal condensation in embryological hair follicle induction. Gene expression analysis using RT-PCR showed that the DP-cell marker Versican is expressed at high levels in ASCs under routine culture conditions and the exposure of ASCs to Wnt results in a more than threefold increase in this expression. These results suggest that Wnt/β-catenin signalling may regulate DP cell aggregative growth through modifying versican expression possibly through binding of β-catenin to the TCF transcription factor complex. Culture of ASCs using the hanging drop method produces spheroids similar in size to human hair follicle DP. Histology of these spheroids demonstrates viable cells that flatten around the outside. The spheroids grow out when replated onto Matrigel in a 3D culture model and exhibit a morphology similar to that of primary hair follicle DP cells. Analysis of mRNA expression demonstrates that Versican expression is significantly upregulated in DP-like spheroids in the absence or presence of Wnt demonstrating that Versican may be responsible for both induction and maintenance of mesenchymal cell condensates. Alpha smooth muscle actin is expressed in low levels in ASC spheroids compared to ASCs in a monolayer and this may reflect a 'migratory’ myofibroblast like phenotype of ASCs in a monolayer similar to cells with the hair follicle dermal sheath. The addition of Wnt to ASC spheroids has no additional effect on Versican expression possibly reflecting a negative feedback loop resulting from high local concentrations of endogenous Wnt expression from ASCs. The results of this study show that spheroid cell culture and exposure to Wnt of ASCs results in cell clusters with similar morphology and gene expression to hair follicle DP cells. The novel method of DP-like cell generation described in this study makes use of cells that are readily obtainable from patients and require minimal time and manipulation in culture and therefore could potentially be rapidly translatable to clinical trials.

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Banani, M. A., M. Rahmatullah, N. Farhan, Zoe Hancox, Safiyya Yousaf, Z. Arabpour, Moghaddam Z. Salehi, M. Mozafari, and Farshid Sefat. "Adipose tissue-derived mesenchymal stem cells for breast tissue regeneration." Future Medicine, 2021. http://hdl.handle.net/10454/18391.

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Yes
With an escalating incidence of breast cancer cases all over the world and the deleterious psychological impact that mastectomy has on patients along with several limitations of the currently applied modalities, it's plausible to seek unconventional approaches to encounter such a burgeoning issue. Breast tissue engineering may allow that chance via providing more personalized solutions which are able to regenerate, mimicking natural tissues also facing the witnessed limitations. This review is dedicated to explore the utilization of adipose tissue-derived mesenchymal stem cells for breast tissue regeneration among postmastectomy cases focusing on biomaterials and cellular aspects in terms of harvesting, isolation, differentiation and new tissue formation as well as scaffolds types, properties, material–host interaction and an in vitro breast tissue modeling.

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Edbom, Katarina. "Characterization of adipose derived mesenchymal stem cells received via automated extraction." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-48506.

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MacKay, Maria-Danielle L. "Characterization of Medullary and Human Mesenchymal Stem Cell-Derived Adipocytes." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1232775772.

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Prasad, Ankur. "The role of aortic carboxypeptidase-like protein in adipose-derived mesenchymal stem cell adipogenesis and fibrosis." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12193.

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Thesis (M.A.)--Boston University
The prevalence of obesity and obesity related diseases are increasing worldwide. Obesity is characterized by the pathological expansion of white adipose tissue. Previous studies on white adipose tissue of obese individuals have detected inflammation and fibrosis. These conditions may cause dysregulation of the tissue, leading to negative outcomes, including type II diabetes and metabolic syndrome. Aortic carboxypeptidase-like protein (ACLP) is a secreted extracellular matrix protein that is upregulated in fibrotic lung tissue. Importantly ACLP knockout mice are protected from experimentally induced lung fibrosis. ACLP is expressed in adipose tissue and is downregulated as stem cells undergo adipogenesis. Its overexpression increases α smooth muscle actin expression and impairs adipogenesis in preadipocyte lines; however, its role in white adipose tissue fibrosis has not been fully explored. The studies presented in this thesis aimed to investigate the hypothesis that ACLP overexpression in fibrotic white adipose tissue would promote a fibroblast to myofibroblast transition and repress adipogenesis. To determine if ACLP promotes a fibroblast to myofibroblast transition, we tested the capacity of ACLP to induce α smooth muscle actin and collagen I protein expression and increase contractility of primary stromal vascular cells. To assess the effects of ACLP on adipogenesis, we tested the ability of 10T1/2 fibroblasts and stromal vascular cells to undergo adipogenesis in collagen I gels under ACLP treatment. Results presented herein demonstrate ACLP is a potent inhibitor of adipogenesis and induces an upward trend in myofibroblast proteins and RNA expression. Significantly, these studies used murine adipose-derived cells to show the effects of ACLP, suggesting these results might be reflected in adipose tissue. These experiments support a model where ACLP potentiates adipose tissue fibrosis by inhibiting adipogenesis, resulting in fewer developing adipocytes, and stimulating myofibroblast differentiation, resulting in further collagen deposition and tissue compaction. This contribution to adipose tissue dysfunction also gives ACLP a possible role in the development of obesity related diseases, including diabetes and metabolic syndrome, identifying it as a possible target for therapeutics.

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PITRONE, Maria. "ISOLATION AND CHARACTERIZATION OF VISCERAL- AND SUBCUTANEOUS ADIPOSE-DERIVED MESENCHYMAL STEM CELLS: PUTATIVE ROLE IN OBESITY AND METABOLIC SYNDROME." Doctoral thesis, Università degli Studi di Palermo, 2014. http://hdl.handle.net/10447/91235.

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Wong, Andrew P. "REGENERATIVE POTENTIAL OF MESENCHYMAL STEM CELL DERIVED EXOSOMES." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5856.

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Bone defects are a pervasive complication arising from many clinical conditions, both mechanical and pathological. Current treatments for large bony defects focus on applying bone grafts or synthetic materials to the defect area. Cell-based—and especially stem-cell—therapies have advanced greatly thanks to increasing attention focused on their ability to generate new tissues in situ with biomechanical properties approaching that of native tissue, but they suffer from their own shortcomings as well. Exosomes have been shown to play critical roles in cell-signaling and tissue regeneration and are therefore potentially ideal therapeutic vehicles for treating bone defects. Exosomes are small microvesicles counted amongst stem cells’ paracrine factors capable of delivering nucleic acid and enzymatic protein cargoes in a targeted 2 manner. Our previous studies have shown that hMSC-Exosomes are both proliferative and chemotactic, inhibit inflammatory cytokine production, and suppress osteoclast differentiation. Our long term goal is to develop hMSC-Exosome as a clinical therapy for bone regeneration. The objectives of this study were to determine the ability of hMSC-Exosome to enhance bone healing in a rat calvarial defect model, and to further investigate the integrity of the exosome under certain storage conditions. The specific aims of this study were: 1) To determine the osteogenic potential of hMSC-Exosomes in rat calvarial defects, and 2) To determine the impact of variable storage conditions on the integrity of exosomes. To investigate in vivo regenerative potential, rats with surgically-created craniotomy defects were treated with hMSC-Exosome suspension via a collagen gel matrix. After 4 weeks, the calvaria were harvested and analyzed via micro-CT. Volumetric micro-CT analysis showed that hMSC-Exosome could significantly enhance center healing, structural integrity, and growth uniformity in a calvarial defect model. Western blot and TEM showed thorough destruction of surface protein markers and decreased membrane integrity in lyophilized exosome fraction; moderate progressive surface protein marker loss and aggregation were observed with increasing freeze-thaw cycles. In summary, hMSC-Exosome is a promising therapeutic for treatment of bone defects.

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Lin, Wenyu. "Investigating the immunomodulatory properties of human embryonic stem cell-derived mesenchymal stem cells." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/7060.

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The immunosuppressive property of mesenchymal stem cells (MSC) has been utilised to ameliorate autoimmune reactions such as graft-versus-host disease. However, variation exists in primary MSC isolated due to differences in donor age and tissue of origin. Alternatively, human embryonic stem cells (hESC) can be differentiated to homogeneous populations of MSC (hESCMSC), thus providing an unlimited source of MSC for cell therapy. In this study, the immunomodulatory properties of two hESC-MSC lines, hESC-MSC1 and hESC-MSC2, were compared with adult bone marrow-derived MSC (BM-MSC) and neonatal foreskin fibroblast (Fb). hESC-MSC were able to suppress the proliferation of anti-CD3/CD28-stimulated CD4+ T cells in contact and transwell systems. The immunosuppression was demonstrated by both the carboxyfluorescein diacetate succinimidyl ester (CFSE) and [3H]- thymidine proliferation assays. However, hESC-MSC were less potent and twice the number of adherent hESC-MSC (as measured by IC50) compared to BM-MSC and Fb were required to suppress T cell proliferation by 50%. Supernatants collected from transwells of MSC or Fb with T cells were shown to suppress T cell proliferation, suggesting that suppressive factors were only produced in the presence of activated T cells. Among several candidates, endothelial monocyte-activating polypeptide-II (EMAP-II) was identified as a potential suppressive factor. T cells also induced indoleamine-2,3- dioxygenase (IDO) expression in MSC and Fb. IDO led to the depletion of tryptophan, an essential amino acid, and/or the production of tryptophan metabolites (kynurenines), thereby inhibiting T cell proliferation. Interestingly, blocking of IDO with 1-methyltrytophan reversed the suppressive effect, implicating IDO as a potential mediator in T cell suppression. Concomitantly, several candidate suppressive factors in the supernatants have also been identified using antibody arrays. However, their functions require validation. In conclusion, hESC-MSC share similar suppressive properties as BM-MSC and represent a potential cell source for clinical purposes.

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AL, HAJ GHINA. "EFFECTS OF LIPID MIXTURE AND A SELECTIVE PPARG MODULATOR ON THE DIFFERENTIATION CAPABILITIES OF HUMAN DERIVED MESENCHYMAL STEM CELLS(HADSCS) DERIVED FROM HEALTHY AN D BREAST CANCER PATIENTS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/784157.

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La sindrome metabolica è associata a molte complicanze che portano in particolare a malattie potenzialmente letali come l'obesità e il cancro. Per essere in grado di identificare soluzioni e trattamenti efficaci, dobbiamo indagare le cause alla base di questa sindrome. La nutrizione è un fattore importante da considerare nella prevenzione e nel trattamento della sindrome metabolica. La nutrizione ha effetto su quasi tutti i meccanismi del metabolismo del corpo umano, anche sull’adipogenesi Negli ultimi anni, è stato posto un enorme interesse sulo studio dell'adipogenesi in relazione soprattutto all'obesità. Diversi fattori influenzano l'adipogenesi primi fra tutti i nutrienti presenti nella dieta. Tra i nutrienti con effetto di contrasto all’obesità, i composti dietetici naturali godono di particolare interesse per aiutare a diminuire l'adiposità, quindi il rischio di sviluppare l'obesità e successivamente malattie correlate all'obesità come le malattie cardiovascolari e il diabete ma anche il cancro al seno. Per poter studiare questa correlazione in vitro, è possibile utilizzare un'ampia scelta di modelli cellulari. Le cellule mesenchimali isolate dal tessuto adiposo (hADSCs) sono una dei modelli sperimentali in vitro più usate per studiare l'adipogenesi superando i limiti che altri modelli cellulari hanno nella loro traslabilità all'uomo. In questo studio, lo scopo è stato di studiare l'adipogenesi utilizzando hADSCs anche in presenza di composti dietetici come lipidi e GMG-43AC un modulatore del recettore g (PPAR g) recettore gamma attivato dai proliferatori dei perossisomi. che ha mostrato un effetto positivo sull'inibizione dell'adipogenesi in cellule murine 3T3-L1. Inoltre, abbiamo indagato ulteriormente la sua applicazione su modelli di cellule umane per capire il suo meccanismo d’azione specifico che porta all’ inibizione di questo fenomeno. La parte sperimentale è stata impostata utilizzando la linea cellulare THP-1 differenziate a macrofagi in co-cultura con le hADSCs. Abbiamo notato che trattando le hADSCs con un cocktail di miscela lipidica, VI si verifica la diminuzione dell’espressione delle citochine pro-infiammatorie IL-6 e IL- 1b, valutata mediante real-time RT_PCR. Abbiamo anche notato un aumento dosedipendente dell’espressione di FABP-4. Inoltre, abbiamo anche dimostrato che le capacità differenziative di hADSCs isolate da tessuto adiposo peri-tumorale in casi di tumore della mammella, sono alterate. In questi casi le hADSCs hanno scarse capacità differenziative, valutate mediante saggi istologici ed espressione dell’mRNA di PPARγ e FABP-4. Al contrario, la presenza nel terreno di coltura delle hADSCs di una miscela lipidica (Composizione: acidi grassi non animali; 2 μg / ml arachidonico; 10 μg / ml di acido linoleico; 10 μg / ml di acido linolenico; 10 μg / ml di acido miristico;10 μg / ml di acido oleico; 10 μg / ml di acido palmitico; 10 μg / ml di acido stearico; 0,22 mg / ml di colesterolo dalla lana di pecora della Nuova Zelanda; 2,2 mg / ml di Tween-80; 70 μg / ml di tocoferolo acetato) ripristina l’espressione di PPARγ e l'accumulo di lipidi. In secondo luogo, GMG-43AC in entrambe le concentrazioni (0,5 mM e 2 mM) ha inibito l'accumulo di lipidi e ha mostrato una significativa diminuzione nell'espressione di geni specifici degli adipociti, come PPARγ, FABP-4 anche dopo la completa differenziazione di hADSC derivati da lipoaspirati . Ciò suggerisce che i composti dietetici sono fattori importanti nel differenziamento adipocitario e la dieta ha una grande influenza nella progressione e nella prevenzione di molte malattie metaboliche, tra cui l'obesità e il cancro.
Metabolic syndrome is associated with many complications especially leading to life threatening disorders such as obesity and cancer. To be able to identify solutions and natural treatments, we need to investigate the underlying causes of this syndrome. Nutrition is one important factor to consider in the prevention and treatment of the metabolic syndrome. Nutrition effects almost all metabolism mechanisms in the human body. One provident effect of nutrition is adiposity. Over the recent years, an interest was noted to studying adipogenesis in relation to obesity. Different factors affect adipogenesis including natural dietary compounds to help decrease adiposity, therefore the risk of developing obesity and later on obesity related diseases such as breast cancer. To be able to study this correlation in-vitro, a wide choice of cell models can be used. Human adipose derived mesenchymal cells (hADSCs) are one of the top choices used to study adipogenesis overcoming the limitations that other cell models have in their applicability to humans regarding the prevailing difference in their metabolism and physiology. In this study, the aim was to study adipogenesis using hADSCs in presence of dietary compounds such as lipids and GMG-43AC, a natural selective peroxisome proliferator-activated receptor g (PPAR g) modulator, that seems to have a positive effect on inhibiting adipogenesis in murine 3T3-L1 cells. We wanted to investigate further on its application on human cell models and try to understand its mechanism in inhibiting this phenomenon. The protocols were set up using the THP-1 cell line, which we noticed upon using a Lipid mixture cocktail (Composition: Non-animal fatty acids; 2 μg/ml arachidonic; 10 μg/ml linoleic acid; 10 μg/ml linolenic acid: 10 μg/ml myristic acid; 10 μg/ml oleic acid; 10 μg/ml palmitic acid; 10 μg/ml stearic acid; 0.22 mg/ml cholesterol from New Zealand sheep′s wool; 2.2 mg/ml Tween-80; 70 μg/ml tocopherol acetate), a decrease in pro-inflammatory cytokines IL-6 and IL-1b. We also noticed a doseIV dependent increase of FABP-4. Our findings regarding hADSCs, that PPARγ expression and lipid accumulation was restored upon the presence of lipid mixture in breast cancer hADSCs that were derived from breast tissue. Secondly, GMG-43AC in both concentrations (0.5mM and 2mM) inhibited lipid accumulation and showed a significant decrease in the expression of adipocyte-specific genes, such as PPARγ and FABP-4 even after the full differentiation of hADSCs that were derived from lipoaspirates. This suggests that dietary compounds are important factors in adipose differentiation and diet has a big influence in the progression and prevention in many metabolic diseases, such as obesity and cancer.

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Книги з теми "Adipose-derived mesenchymal stem cell"

Adipose-derived stem cells: Methods and protocols. New York, NY: Humana Press, 2011.

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Mesenchymal Stem Cell Derived Exosomes. Elsevier, 2015. http://dx.doi.org/10.1016/c2013-0-15342-1.

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Tang, Yaoliang, and Buddhadeb Dawn. Mesenchymal Stem Cell Derived Exosomes: The Potential for Translational Nanomedicine. Elsevier Science & Technology Books, 2015.

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Tang, Yaoliang, and Buddhadeb Dawn. Mesenchymal Stem Cell Derived Exosomes: The Potential for Translational Nanomedicine. Elsevier Science & Technology Books, 2015.

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Al-Anazi, KA, WK Al-Anazi, and AM Al-Jasser. Update on COVID-19 Infections and the Promising Role of Mesenchymal Stem Cell Therapies in their Management. Heighten Science Publications Inc., 2020. http://dx.doi.org/10.29328/ebook1002.

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The pandemic of COVID-19 has adversely affected almost every aspect of our lives but the world health and economic sectors suffer most of the repercussions of this disease. The search for a cure for this rapidly spreading virus which is causing massive life losses around the globe requires clear understanding of the immunopathogenesis of this virus as well as the mechanisms of actions of the various therapeutic modalities that are employed in the treatment of this life-threatening viral infection. Mesenchymal stem cells have antimicrobials effects in addition to their anti-inflammatory and immunomodulatory properties. They have been utilized in the treatment of various infections and their complications both in animal models and in human clinical trials. Mesenchymal stem cells derived from certain sources and their secretory products are particularly effective in the treatment of pneumonia, sepsis, acute lung injury, and acute respiratory distress syndrome which are common complications of COVID-19 infections. The review will discuss the various aspects of COVID-19 and it will highlight the promising role of mesenchymal stem cells in treating the complications of COVID-19 infections.

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Bahadori, Mohammad Hadi. Cryopreservation of Rat Bone Marrow Derived Mesenchymal Stem Cells by Two Conventional and Open-Pulled Straw Vitrification Methods. INTECH Open Access Publisher, 2012.

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Liu, Hong Bin. Bone Marrow Derived Mesenchymal Stem Cells Are Recruited into Injured Pancreas and Contribute to Amelioration of the Chronic Pancreatitis in Rats. INTECH Open Access Publisher, 2012.

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Частини книг з теми "Adipose-derived mesenchymal stem cell"

Fraser, John K., Min Zhu, Isabella Wulur, and Zeni Alfonso. "Adipose-Derived Stem Cells." In Mesenchymal Stem Cells, 59–67. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-169-1_4.

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Weiss, Jeffrey N. "Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis." In Orthopedic Stem Cell Surgery, 41–48. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73299-8_10.

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Weiss, Jeffrey N. "Adipose-derived Mesenchymal Stem Cells in Osteoarthritis." In Orthopedic Stem Cell Surgery, 107–13. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73299-8_19.

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Vidal, Martin A., and Mandi J. Lopez. "Adipogenic Differentiation of Adult Equine Mesenchymal Stromal Cells." In Adipose-Derived Stem Cells, 61–75. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-61737-960-4_6.

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Assoni, Amanda Faria, Giuliana Castello Coatti, Juliana Plat Aguiar Gomes, Mayra Vitor Pelatti, and Mayana Zatz. "Adipose-Derived Mesenchymal Stromal Cells." In Working with Stem Cells, 37–55. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-30582-0_3.

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Kroeze, Robert Jan, Marlene Knippenberg, and Marco N. Helder. "Osteogenic Differentiation Strategies for Adipose-Derived Mesenchymal Stem Cells." In Adipose-Derived Stem Cells, 233–48. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-61737-960-4_17.

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Kim, Yeon Jeong, and Jin Sup Jung. "Methods for Analyzing MicroRNA Expression and Function During Osteogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stem Cells." In Adipose-Derived Stem Cells, 401–18. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-61737-960-4_29.

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Zachar, Vladimir, Jeppe Grøndahl Rasmussen, and Trine Fink. "Isolation and Growth of Adipose Tissue-Derived Stem Cells." In Mesenchymal Stem Cell Assays and Applications, 37–49. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-60761-999-4_4.

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Dubois, Severine G., Elizabeth Z. Floyd, Sanjin Zvonic, Gail Kilroy, Xiying Wu, Stacy Carling, Yuan Di C. Halvorsen, Eric Ravussin, and Jeffrey M. Gimble. "Isolation of Human Adipose-derived Stem Cells from Biopsies and Liposuction Specimens." In Mesenchymal Stem Cells, 69–79. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-169-1_5.

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Weiss, Jeffrey N. "Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells (GXCPC1) for Knee Osteoarthritis." In Orthopedic Stem Cell Surgery, 155–57. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73299-8_28.

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Тези доповідей конференцій з теми "Adipose-derived mesenchymal stem cell"

Katsube, Yoshihiro, Ousuke Hayashi, Motohiro Hirose, and Hajime Ohgushi. "Adipose Tissue-derived Mesenchymal Stem Cells have Lower Osteogenic Potential than Bone Marrow-derived Mesenchymal Stem Cells." In In Commemoration of the 1st Asian Biomaterials Congress. WORLD SCIENTIFIC, 2008. http://dx.doi.org/10.1142/9789812835758_0005.

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Guo, Bao-Feng, Ling Zhang, Wei-Tian Yin, Kun Ji, and Zhuang Wei. "Multipotential Capacity of Human Adipose-Derived Mesenchymal Stem Cells." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5517449.

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Levy, Debora, Suelen Silva, Thatiana Melo, Jorge Ruiz, Cesar Isaac, Maíra Fidelis, Alessandro Rodrigues, and Sergio Bydlowski. "Abstract A71: Effect of oxysterols in adipose tissue-derived mesenchymal stem cell." In Abstracts: AACR International Conference held in cooperation with the Latin American Cooperative Oncology Group (LACOG) on Translational Cancer Medicine; May 4-6, 2017; São Paulo, Brazil. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1557-3265.tcm17-a71.

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Ritter, A., A. Friemel, NN Kreis, SC Hoock, S. Roth, U. Kielland-Kaisen, D. Brüggmann, C. Solbach, F. Louwen, and J. Yuan. "Primary cilia are dysfunctional in obese adipose-derived mesenchymal stem cells." In 62. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe – DGGG'18. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1671441.

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Erdost, Hatice. "‘Comparison of Subcutan and Inguinal Adipose Tissue Derived Mesenchymal Stem Cells’." In 15th International Congress of Histochemistry and Cytochemistry. Istanbul: LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.pp-53.

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Sharaf, K., A. Kleinsasser, O. Gires, M. Canis, S. Schwenk-Zieger, and F. Haubner. "Molecular characterization of lipoaspirate-derived adipose mesenchymal stem cells in wound healing." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686895.

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Kuca-Warnawin, E., U. Skalska, M. Plebanczyk, I. Janicka, U. Musialowicz, K. Bonek, P. Głuszko, and E. Kontny. "P116 Basic characteristics of adipose-derived mesenchymal stem cells of ankylosing spondylitis patients." In 39th European Workshop for Rheumatology Research, 28 February–2 March 2019, Lyon, France. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2018-ewrr2019.104.

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Skalska, Urszula, Ewa Kuca-Warnawin, Tomasz Burakowski, Anna Kornatka, Iwona Janicka, Urszula Musiałowicz, and Ewa Kontny. "03.14 Comparison of immunosuppressive potential of rheumatoid adipose mesenchymal stem cells derived from articular and subcutaneous adipose tissues." In 37th European Workshop for Rheumatology Research 2–4 March 2017 Athens, Greece. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2016-211049.14.

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Kuca-Warnawin, E., U. Skalska, I. Janicka, K. Bonek, P. Głuszko, W. Maslinski, and E. Kontny. "P115/O19 Immunomodulatory activity of adipose-derived mesenchymal stem cells of ankylosing spondylitis patients." In 39th European Workshop for Rheumatology Research, 28 February–2 March 2019, Lyon, France. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2018-ewrr2019.103.

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Alihemmati, Zakieh, Bahman Vahidi, and Nooshin Haghighipour. "Mechanical modulation study of an adipose-derived mesenchymal stem cell under pressure loading: A numerical investigation on cell engineering." In 2014 21th Iranian Conference on Biomedical Engineering (ICBME). IEEE, 2014. http://dx.doi.org/10.1109/icbme.2014.7043893.

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Donohue, Henry J., Christopher Niyibizi, and Alayna Loiselle. Induced Pluripotent Stem Cell Derived Mesenchymal Stem Cells for Attenuating Age-Related Bone Loss. Fort Belvoir, VA: Defense Technical Information Center, September 2013. http://dx.doi.org/10.21236/ada606237.

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Donahue, Henry J. Induced Pluripotent Stem Cell Derived Mesenchymal Stem Cells for Attenuating Age-Related Bone Loss. Fort Belvoir, VA: Defense Technical Information Center, July 2012. http://dx.doi.org/10.21236/ada581680.

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Brennen, William N. Bone Marrow-derived Mesenchymal Stem Cells (MSCs) as a Selective Delivery Vehicle for a PSA-Activated Protoxin for Advanced Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, March 2013. http://dx.doi.org/10.21236/ada580995.

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Brennen, William. Bone Marrow-derived Mesenchymal Stem Cells (MSCs) as a Selective Delivery Vehicle for a PSA-Activated Protoxin for Advanced Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, April 2014. http://dx.doi.org/10.21236/ada602710.

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