Дисертації з теми "Adhesion resistance"
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Lougheed, Caroline. "Targeting focal adhesion signaling in cancer and acquired resistance to focal adhesion kinase inhibitors." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=94996.
Dans la progression du cancer, le développement de métastases est caractéristique de la phase terminale et rend le traitement difficile. Afin que des métastases se dévelopment, les cellules cancéreuses doivent acquérir de la motilité ainsi qu'un phénotype invasif. Considéré come l'une des plus importantes protéines participant dans la motilité cellulaire, la prot éine Focal Adhesion Kinase (FAK) a émergé comme une bonne cible thérapeutique pour l'inhibition de métastases par la création de drogues ciblées et de petites molécules inhibitrices. Par conséquent, une molécule inhibitrice de l'activation de FAK et sa signalisation a été récemment développée. Cependant, J'ai demontré que la résistance est commune parmis ces drogues. Le dévelopement et la classification des clones de cellules résistantes ont permi d'élucider un mécanisme impiquant en partie une amplification de l'activité FAK; ce mécanisme permetter a de découvrir des analogues de deuxième génération pour surmonter ou éviter la résistance. L'ensemble de données présentées ci-dessous supportet le rôle de FAK comme une cible importante dans la prévention de métastases et exposent les futur directions pour contourner la résistance aux inhibiteurs de FAK.
Ahlberg, Jesper, and Esbjörn Blomquist. "Online Identification of Running Resistance and Available Adhesion of Trains." Thesis, Linköpings universitet, Fordonssystem, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71301.
Två viktiga fysikaliska aspekter som bestämmer prestandan för ett tåg i drift är det totala gångmotståndet som verkar på hela tåget, samt den tillgängliga adhesionen (användbara hjul-räl-friktionen) för framdrivning och bromsning. Från de tillgängliga signalerna önskas identifiering, samt prediktering, av dessa två storheter, under drift. Med målet att förbättra precisionen av dessa skattningar undersöker detta examensarbete potentialen av skattning och prediktering av gångmotstånd och adhesion med hjälp av Extended KalmanFiltering. Slutsatsen är att problem med observerbarhet och känslighet uppstår, vilket resulterar i ett behov av sofistikerade metoder att numeriskt beräkna acceleration från en hastighetssignal. Metoden smoothing spline approximation visar sig ge de bästa resultaten för denna numeriska derivering. Känsligheten och dess medförda krav på hög precision, speciellt på accelerationssignalen, resulterar i ett behov av högre samplingsfrekvens. Ett behov av andra adekvata metoder att tillföra ytterligare information, eller att förbättra modellerna, ger upphov till möjliga framtida utredningar inom området.
Munch, Sabine M. G. "Influence of interfacial adhesion on the fracture resistance of polymer multilayers." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445160.
St, Croix Bradley D. "Impact of intercellular adhesion on cell cycle and resistance to anticancer agents." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ35331.pdf.
Ebert, Daniel Ray. "Superhydrophobic, Biomimetic Surfaces with High and Low Adhesion, Optical Transmittance, and Nanoscale Mechanical Wear Resistance." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1475516443008829.
Nejmeh, Kassem. "Enhancing adhesion and Water Resistance in Clayey adhesives Mixtures : Strategies for Vertical and Horizontal Applications." Electronic Thesis or Diss., Université Gustave Eiffel, 2024. http://www.theses.fr/2024UEFL2012.
Earthen material has long been favored in building construction for its eco-friendly characteristics. Fine clay particles play a crucial role in enhancing the cohesion of such materials. This research focuses on exploring clay-based mixtures as potential substitutes for traditional tile adhesives used on concrete slabs. The objective is to develop a material that exhibits strong adhesion resistance and maintains its integrity even when submerged in water. Considering the porous nature of the clay mixture, adherence to specific drying conditions and immersion periods becomes crucial.The initial stage of the investigation involves conducting a mechanical test to measure the adhesive stress of the material before and after water immersion. A reference soil sample serves as the baseline for evaluating this stress. To influence the mechanical properties, we introduce a proportional amount of polymers or fibers into the reference soil, aiming to alter its cohesive attributes. The selection of polymers or fibers is strategic, intended to induce changes in the material's mechanical properties and its resistance to water.In the subsequent phase, the study focuses on understanding the drying process and imbibition kinetics following the addition of polymers. Additionally, we provide evidence that the choice of polymer significantly affects the kinetics of immersion and the degree of water absorption.The research approach unfolds in three distinctive scenarios: firstly, we enhance the strength of the mortar by incorporating diverse polymers and fibers; secondly, we aim to impede water absorption into the adhesive; and finally, we endeavor to develop a reversible adhesive capable of reclaiming its mechanical strength after experiencing loss due to immersion, solely through a drying process. Moreover, we devise strategies specific to different application methods, addressing both vertical and horizontal applications
Sun, Xiaowen. "An integrin-based mechanism for sensitizing melanomas to therapies." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/6506.
Tan, Jiahong Brash John L. "Polyethylene oxide-containing block copolymers as surface modification additives in polyurethanes for protein and cell resistance /." *McMaster only, 2004.
Klittich, Mena R. "Surface Interactions with Hierarchical Nanostructures: From Gecko Adhesion to Thermal Behavior." University of Akron / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=akron1499440265902425.
Nakanishi, Takao. "The synergistic role of ATP-dependent drug efflux pump and focal adhesion signaling pathways in vinorelbine resistance in lung cancer." Kyoto University, 2019. http://hdl.handle.net/2433/236608.
Di, Martino Patrick. "Caracterisation de facteurs impliques dans l'adhesion aux cellules epitheliales intestinales de souches de klebsiella pneumoniae responsables d'infections nosocomiales." Clermont-Ferrand 1, 1996. http://www.theses.fr/1996CLF1MM04.
Wang, Xisheng. "Mechanisms of IFN-gamma-mediated Resistance against Development of Toxoplasmic Encephalitis." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/30268.
Ph. D.
Chu, Calvin. "MCP-1 Induces Rapid Formation of Tethered VLA-4 Bonds with Increased Resistance to Applied Forcein THP-1 Cells." Scholarly Repository, 2011. http://scholarlyrepository.miami.edu/oa_dissertations/592.
Opp, Daniel. "Transendothelial Migration of Metastatic Cancer Under the Influence of Cigarette Smoke Condensate." Scholar Commons, 2007. http://scholarcommons.usf.edu/etd/3808.
Boban, Greg. "Tribological Comparison of Traditional and Advanced Firearm Coatings." DigitalCommons@CalPoly, 2010. https://digitalcommons.calpoly.edu/theses/361.
Forestier, Jean-Paul. "Caracterisation de l'interface composite de collage / attaches orthodontiques." Paris 7, 1997. http://www.theses.fr/1997PA07GA03.
Adsero, Matthew E. "Impact of Jet Grouting on the Lateral Strength of Soil Surrounding Driven Pile Foundations." BYU ScholarsArchive, 2008. https://scholarsarchive.byu.edu/etd/1378.
Avril, Florence. "Développement de nouvelles formulations polymères thermoplastiques pour l’élaboration de multi-matériaux sandwich acier / polymère / acier." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10324.
The aim of this work is to develop multimaterials such as steel/polymer/steel composites for weight savings in automotive industry. To fully take advantage of properties of both steel and polymer materials, adhesion steel-polymer must be well controlled. Moreover, the composite must be compatible with processing on the industrial line and last not least, the structure must be flow resistant during the cataphoresis step (Painting process at 200°C for 30 minutes). This last condition is essential and our work will focuse on the development of compatibilized polymers blend made of polyamide 11 and polyolefin grafted maleic anhydride with yield stress properties. We successfully optimize the formulation via morphological control in order to develop a yield stress fluid with good adhesive properties
Gomand, Faustine. "Bacterial abilities to adhere to food components : extent, characterisation, and sensitivity to shear stress." Thesis, Université de Lorraine, 2019. http://www.theses.fr/2019LORR0123.
In the last decade, there has been an increasing interest in the potential health effects associated with consumption of Lactic Acid Bacteria (LAB) in foods. Adhesive interactions between bacteria and food components are likely to play a key role on bacterial probiotic action by modulating both bacterial protection and distribution within food matrices. Research presented in this thesis aims a better understanding of these interactions to help optimizing functional food design. Indeed, the adhesive behavior of most LAB, as well as the impact of adhesive interactions on food structuration, remain mostly unknown. Furthermore, some food manufacturing steps, such as spray-drying, may induce stress on bacteria, which can cause partial loss of bacterial adhesive capacities. In case of bacteria integrated within an adhesive matrix, the effect of adhesive interactions on bacterial protection from stress can also be questioned. A high-throughput screening method was first designed to screen quickly a hundred of strains for their adhesive affinities towards a given range of biomolecules of interest. This method was then applied to a 73-LAB strains collection which allowed identifying common characteristics amongst adhesive strains, especially in terms of adhesion specificity. Two studies (experimental and theoretical) were performed in parallel to determine the impact of shear stress on bacterial functionality and bacterial chains integrity. These studies suggest that the stress-induced breaking-down process of bacterial chains can be thought of as a functionality protective process. The proposed model predicts regioselectivity of damages inflicted to bacterial cells within a chain, which intensity would vary with chain length. When applied to bacteria-spherical component adhesive interactions within a food matrix submitted to shearing, the model suggests an unfavorable impact of adhesion on bacterial cell damages, which would be all the more important than spheres are big. This multidisciplinary research project points out several key findings that may help with designing more efficient food matrices for optimized LAB delivery
Neto, Jadir Rodrigues Fagundes. "Acompanhamento clínico-laboratorial da utilização de Enfuvirtida em pacientes HIV soropositivos multiexperimentados atendidos nos ambulatórios do Hospital Universitário Pedro Ernesto." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=5973.
Enfuvirtide (ENF) is the only fusion inhibitor available. It is an interesting option for patients with HIV infection when used in combination with other antiretroviral drugs, especially in the treatment of multi-experienced patients with virological failure and few therapeutic options. Its effectiveness confirmed in clinical trials finds the barriers in its parenteral administration. Using these data, we evaluated, for 48 weeks, the virological response, evolution of CD4 T cells, the possible primary resistance to ENF and the impact to the subcutaneous use of the drug in ten patients undergoing outpatient monitoring at Hospital Universitário Pedro Ernesto with a history of more than ten years of HIV infection and use of ENF in their therapy, as suggested by resistance testing. All patients have successfully completed the therapy by the end of follow-up with an undetected viral load and a significant average increase of CD4 T lymphocytes. As for a possible primary resistance, neither the genotyping nor the glycoprotein 41 revealed natural mutations that could diminish the effect of ENF. Concerning the management, preparation and application of the drug, we found that a multidisciplinary support is essential to avoid that the drug be discontinued
Danoumbé, Bonaventure. "Étude de couches minces de cuivre sur substrat YIG en vue de réaliser des composants magnétiques passifs planaires pour un fonctionnement à haute température." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSES022/document.
The objective of the works carried out during this thesis concerns the study and realization of planar passive components with magnetic layers (YIG) operating at high temperature (200 ° C). For this, studies were carried out in two phases: a first part on the mechanics of stacking thin films and a second part on the electrical characterization of thin films and planar components realized (planar inductances). The first phase made it possible to demonstrate the mechanical integrity of the structure, that is to say a good adhesion of the thin copper layers on the magnetic substrate (YIG) up to a temperature of 200 ° C. The second phase on the electrical part of the thin layers and the planar components made it possible to demonstrate that no modification has been made to the structure of the component and shows that the component retains these same electrical properties after cycling Thermal (25 ° C - 200 ° C - 25 ° C)
Aleksandar, Miletić. "Razvoj nanoslojnih i nanokompozitnih metal-nitridnih prevlaka." Phd thesis, Univerzitet u Novom Sadu, Fakultet tehničkih nauka u Novom Sadu, 2015. http://www.cris.uns.ac.rs/record.jsf?recordId=95438&source=NDLTD&language=en.
With the aim to develop hard coatings characterized by both, high hardnessand high resistance to cracking, synergy between nanolayered andnanocomposite design was made and nanolayered TiAlN/TiSiN andCrAlN/TiSiN coatings were produced. Monolayer TiAlN, nanocompositeTiSiN and multilayer TiAlN/TiSiN were also studied in order to find therelation between the coating design and their properties. All coatings weredeposited with 1-fold, 2-fold and 3-fold rotation. It is shown that coatingdesign and type of rotation have great influence on coating microstructureand texture, and in this way on their mechanical properties, resistance tocracking, adhesion between coating and substrate, surface topography andtribological behavior. Nanolayered and nanocomposite coatings arecharacterized by compact nanocrystalline microstructure, while monolayerTiAlN coatings have columnar structure with larger crystalline grains. Byincreasing the number of rotational degrees from 1-fold to 3-fold size ofcrystalline grains decreases and microstructure becomes more dense.Therefore, nanolayered and nanocomposite coatings deposited with 2-foldand 3-fold rotation are characterized by the highest hardness, highestresistance to cracking, highest wear resistance and the smoothest surfacetopography.
Korenberg, Capucine Florence. "The durability of adhesive joints." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272387.
Palmer, S. "The mannose-resistant adhesion antigens of uropathogenic Escherichia coli." Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380217.
Saffiedine, Brahim. "Contribution à l'étude du système BAC "Biofilm Associated Cluster" chez Pseudomanas aeruginosa." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR018/document.
Pseudomonas aeruginosa (PA) is a Gram-negative bacterium, opportunistic pathogen, involved in a large number of nosocomial infections. This microorganism is also the main infectious agent involved in bronchopulmonary infections in cystic fibrosis patients. This pre-eminence is partly due to the ability of PA to form biofilms, which confers to the bacterial cells an increased resistance to antibiotics. In our laboratory, a differential proteomic analysis allowed to demonstrate in 2004, the existence of a specific proteome when the bacterium grows in the biofilm mode. This study allowed identifying about 40 proteins, specifically accumulated when bacteria adhere to a surface. Among these proteins, the hypothetical protein PA3731 has been particularly investigated. This protein is involved in the biofilm formation, the rhamnolipids production, the resistance to tobramycin and the swarming mobility. Bioinformatic research showed that the pA3731 gene belongs to a cluster of 4 genes ranging from pA3729 to pA3732 (BAC system), which could be involved in the development and / or regulation of the same protein system. This hypothesis was the starting point of this thesis work. The present study confirmed the involvement of the BAC system in the biofilm formation, the antibiotic resistance and the rhamnolipid production in PA. Proteomic studies highlighted the implication of this system in the expression of the MexEF-OprN pump and that of the OprD porin, and in the regulation of Quorum Sensing. Interactomic investigations, conducted in parallel, showed a strong interaction between PA3731 and PA3732 proteins. These studies have also pointed out a strong interaction between these proteins and rhamnolipids. All these results suggest that the BAC system could play a major role in the transfer of rhamnolipids to the extracellular environment
Pourrahimi, Amir Masoud. "The synthesis, surface modification and use of metal-oxide nanoparticles in polyethylene for ultra-low transmission-loss HVDC cable insulation materials." Doctoral thesis, KTH, Polymera material, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-190808.
Polyetenkompositer med mycket låga halter av ZnO och MgO metalloxid nanopartiklar är en växande kategori material för användning som isolering av extruderade kablar avsedda för likriktad högspänning. En utmaning i utvecklingen av dessa material kan relateras till den praktiska kompositframställningen, vilken innefattar framställning av högrena metalloxid nanopartiklar som ytmodifieras med hydrofoba molekylstrukturer för att möjliggöra blandning med den hydrofoba polyetenplasten. Denna avhandling behandlar olika metoder för att framställa denna generation av isoleringsmaterial. Vid syntesen av de rena nanopartiklarna krävdes optimering av ett antal olika reaktionsparametrar för att uppnå tillfredställande slutresultat i form av partikelstorlekar och partikelmorfologier. Dessa inkluderade val av zinksalt, zinksaltkoncentration vid utfällning, samt reaktionstemperatur vid framställningen. Experimenten avslöjade att olika partikelstorlekar och partikelmorfologier kunde framställas som endast korrelerat mot källan av zinkjonerna, och berodde av vilka motjoner som zinkatomerna haft i zinksaltet (acetat, nitrat, klorid eller sulfat). Optimering av reaktionstemperaturen visade att ca 60 °C utgjorde en lämplig start för utvärdering av synteserna, som resulterade i olika partikelmorfologier i form av pyramidformade nanopartiklar till blomformationer. Utöver de specifika reaktionsparametrarna utvecklades även en ny ultrasonikeringsmetod för att rena ytorna hos partiklarna från motjoner relaterade till de valda specifika salterna. Metodiken som visade sig avsevärt mer effektiv än sedvanlig rening att utfällda nanopartiklar via repetitivt vattenutbyte, och skapade förutsättningar etablering av kolloidal stabilitet och fragmentering av aggregat i vattensuspensionerna. Efter ultrasonikeringsreningen beräknades de kvarvarande zinkhydroxidsalterna (ZHS) utgöra endast ett atomlager ZHS utifrån termogravimetriska data kompletterade med infraröd spektroskopi. En metod att eliminera de kvarvarande ZHS-komplexen från ytan av partiklarna tillämpades/utvecklades, inkluderade ytbeläggning av partiklarna med silan, följt av värmebehandling samt etsning av den resulterande kiseloxidytan, för att uppnå en ren hydroxylyta på partiklarna. Ytkemin hos dessa partiklar modifierades från att bestå av hydroxylgrupper till att utgöras av hydrofoba alkylgrupper med olika längder relaterade metyltrimetoxysilan (C1), oktyltrietoxysilan (C8), eller oktadekyltrimetoxysilan (C18). Även MgO nanopartiklar framställdes via vattenutfällning av Mg(OH)2 partiklar, vilka omvandlades till MgO nanopartiklar via en lågtemperatur värmebehandling vid 400°C. Ytan av dessa partiklar omvandlades dock till hydroxid i fuktig miljö. En ny metod att bibehålla den stora ytarean av MgO nanopartiklarna med anmärkningsvärd motståndskraft mot att omvandlas till hydroxid utvecklades således. Metoden består av (a) en låg temperatur omvandling av Mg(OH)2, (b) en kiseloxidytbehandling av nanopartiklarna för att undvika partikelsintring vid högre temperaturer och (c) en hög temperaturbehandling vid 1000 °C. De framställda partiklarna uppvisade ingen anmärkningsvärd känslighet mot luftfuktighet och bibehöll MgO sammansättningen efter exponering mot fukt. De modifierade metalloxid nanopartiklarna visade mycket liten adsorption av fenoliska antioxidanter, vilket medförde en långtidsstabilitet hos polyeten nanokompositerna. De ytmodifierade metalloxidpartiklarna visade även förbättrade möjligheter för dispergering och yt-kompatibilitet med/i polyetenmatrisen i jämförelse med omodifierade metalloxidpartiklar, utifrån mätningar baserade på dragprovning och svepelektronmikroskopi. Slutligen, de utvecklade ytorna på de modifierade nanopartiklarna skapade ett polymer/nanopartikel gränssnitt som kunder fungera som laddningsansamlingsområden i nanokompositerna, vilket resulterade i en storleksordning minskad ledningsförmåga hos kompositerna jämfört med den rena polyetenen.
QC 20160829
Renza, Jaroslav. "Jízdní dynamika traktoru." Master's thesis, Vysoké učení technické v Brně. Ústav soudního inženýrství, 2016. http://www.nusl.cz/ntk/nusl-241322.
Gomand, Faustine. "Bacterial abilities to adhere to food components : extent, characterisation, and sensitivity to shear stress." Electronic Thesis or Diss., Université de Lorraine, 2019. http://www.theses.fr/2019LORR0123.
In the last decade, there has been an increasing interest in the potential health effects associated with consumption of Lactic Acid Bacteria (LAB) in foods. Adhesive interactions between bacteria and food components are likely to play a key role on bacterial probiotic action by modulating both bacterial protection and distribution within food matrices. Research presented in this thesis aims a better understanding of these interactions to help optimizing functional food design. Indeed, the adhesive behavior of most LAB, as well as the impact of adhesive interactions on food structuration, remain mostly unknown. Furthermore, some food manufacturing steps, such as spray-drying, may induce stress on bacteria, which can cause partial loss of bacterial adhesive capacities. In case of bacteria integrated within an adhesive matrix, the effect of adhesive interactions on bacterial protection from stress can also be questioned. A high-throughput screening method was first designed to screen quickly a hundred of strains for their adhesive affinities towards a given range of biomolecules of interest. This method was then applied to a 73-LAB strains collection which allowed identifying common characteristics amongst adhesive strains, especially in terms of adhesion specificity. Two studies (experimental and theoretical) were performed in parallel to determine the impact of shear stress on bacterial functionality and bacterial chains integrity. These studies suggest that the stress-induced breaking-down process of bacterial chains can be thought of as a functionality protective process. The proposed model predicts regioselectivity of damages inflicted to bacterial cells within a chain, which intensity would vary with chain length. When applied to bacteria-spherical component adhesive interactions within a food matrix submitted to shearing, the model suggests an unfavorable impact of adhesion on bacterial cell damages, which would be all the more important than spheres are big. This multidisciplinary research project points out several key findings that may help with designing more efficient food matrices for optimized LAB delivery
Stodolovská, Šárka. "Vývoj nového chemicky odolného nátěrového systému s obsahem druhotných surovin." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2021. http://www.nusl.cz/ntk/nusl-432472.
Seják, František. "Vývoj speciálních ochranných hmot pro hygienicky čisté provozy." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2017. http://www.nusl.cz/ntk/nusl-265641.
Li, Weihong. "Adhesive Applied Roofing System Resistance Evaluation and its Quantification." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28711.
GONCALVES, ROBERTA AMORIM DE MAGALHAES MONTEIRO. "FRACTURE RESISTANCE EVALUATION OF ADHESIVE INTERFACES IN DENTAL RESTORATIONS." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2013. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=23159@1.
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
O sistema adesivo desempenha um papel importante na restauração dental, uma vez que é o responsável por promover a adesão entre o dente e resina. Apesar do avanço deste material, ele ainda pode apresentar problemas quando atua no tratamento restaurador. Sob ação das cargas de mastigação, os possíveis defeitos presentes na interface adesiva podem atuar como concentradores de tensão. Na presença destas descontinuidades, a interface pode comportar-se de maneira frágil, fraturando abruptamente e comprometer a restauração. Quando essa interface não tem muita resistência à fratura, é caracterizada por baixos valores de tenacidade à fratura, KIc. Portanto, o objetivo do presente estudo foi avaliar, por um método alternativo de testes, a tenacidade à fratura da interface dente / restauração utilizando diferentes sistemas adesivos e resinas compostas. Os terceiros molares foram cortados e restaurados com um entalhe pré-existente. De acordo com o material de restauração (adesivos convencional ou autocondicionante; e resinas compostas híbrida ou nanohíbrida), foram divididos em três grupos. A resistência à fratura foi avaliada por meio de testes de KIc, usando corpos de prova nos quais a zona de processo (região da trinca) é similar à interface de restauração. Após o teste, as superfícies de fratura foram analisadas por microscopia óptica (lupa) e microscopia eletrônica de varredura (MEV) para observar os planos de propagação das trincas nesses ensaios de tenacidade. Análise dos testes mostrou que todos os grupos comportaram-se de maneira semelhante (ruptura frágil), o que foi confirmado pelas análises de superfície. A análise estatística dos valores de KIc para cada grupo indicou haver diferença entre os grupos comparados. Juntamente com a análise qualitativa da média e do desvio padrão, é possível concluir que o material utilizado no Grupo 3 teve um desempenho superior aos outros.
The adhesive system plays an important role in dental restoration, since it is responsible for promoting adhesion between the tooth and the composite resin. Despite the advance of this material, it can still present problems when acting in restorative treatment. Under masticatory loads, the possible flaws present in the adhesive interface can act as stress raisers. In the presence of these discontinuities, the interface can behave fragile, fracturing abruptly and compromising the restoration. When this interface has not much resistance to fracture, is characterized by low values of fracture toughness, KIc. Therefore, the aim of the present study was to evaluate, by an alternative method of testing, the fracture toughness of tooth / restoration interface with different adhesive systems and composite resins. Third molars were cut and restored with a pre-existing crack. According to the restorative material (conventional adhesive or self-etching adhesive, and hybrid or nanohybrid composites), they were divided into three groups. The fracture toughness was measured by KIc testing, using specimens in which the process zone (crack region) is similar to restoration‟s interface. After testing, the fracture surfaces were analyzed by optical microscopy (magnifying glass) and scanning electron microscopy (SEM) to observe the propagation of cracks plans. Analysis of the tests showed that all groups behaved similarly (brittle fracture), which was confirmed by surface analyzes. Statistical analysis of the KIc values for each group indicated difference between the compared groups. With the statistical evaluation and a qualitative analysis of the means and standard deviation was possible to conclude the material used in Group 3 had a better performance than the other groups.
Roche, Soline. "Propriétés viscoélastiques et plastiques par nano-indentation de couches minces polymères solides : étude en température et en pression." Ecully, Ecole centrale de Lyon, 2004. http://www.theses.fr/2004ECDL0013.
The topic of this study was to mechanically characterize in nanoindentation and nanoscratch thin polymers layers. The goal is to improve the understanding of thin polymer layer elastic behavior laid on hard substrate. Tests in nanoindentation and nanoscratch were done on thin polymer films laid on different substrates. A rheologic model was used in order to extract the film elastic properties from the measured value linked to {film+substrate}. A specific behavior of thin polymer film has been identified: the anvil effect. In indentation, it is observed in two different ways : increase of the conservation film modulus with the hardness, linked to the film hardening, and decrease of the loss tangent with the hardness, which is explained by increasing the vitreous transition temperature. In scratch test, this effect is related to the increase of the film mechanical properties. Nanoindentation tests have highlighted residual stresses, mainly thermal driven. A new methodology to characterize those residual stresses for a thin polymer film was presented. An interpretation of the anvil effect is proposed. This effect is linked to thin layer pressurized, confined between diamond indenter and hard substrate. Its mechanical properties grow with hydrostatic pressure. This phenomenon is greater for thin layers (< 50μm) with lower mechanical properties than those of the substrate. A logarithmic type evolution law is proposed. A temperature study show isothermal curves of the conservation modulus with the pressure are shifted. The anvil effect can be described by a unic curve, applying additive constants determined at a given reference temperature. It is the same for the film loss tangent. Moreover, the consequences of the anvil effect on the use properties of polymer coating are analyzed: scratch resistance and the adhesion to substrate. A fundamental application of thin film was studied multilayer coatings. It seems that anvil effect is a phenomenon to consider for improvement of mono or multilayer coating scratch resistance. The results obtained on thin layers allow to choose two mix of basecoat and topcoat in order to have an improved bilayer. We have demonstrated that a basecoat between the topcoat and the hard substrate allow an improved scratch resistance of the final coating
Benyahia, Lazhar. "Relations entre les propriétés rhéologiques et physico-chimiques des polymères et leurs propriétés adhésives : application à la peau." Université Joseph Fourier (Grenoble ; 1971-2015), 1996. http://www.theses.fr/1996GRE10061.
Fisher, Gary Anthony. "The optimisation of bondcoat oxides for improved thermal barrier coating adhesion." Thesis, Cranfield University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245488.
Perrinet, Olivier. "Analyse de l'endurance de contacts électriques Sn, Au et Ag soumis à des sollicitations complexes de fretting usure." Thesis, Ecully, Ecole centrale de Lyon, 2014. http://www.theses.fr/2014ECDL0009.
In automotive applications and in other areas (energy, aviation, etc.), the number of electronic devices has increased significantly in recent last decades. Systems and people securities are based on the quality of electrical connectors. However, submitted to vibrations (car engine, environment) micro-displacements are induced at the interface. The problem of electrical contact is mainly due to the impairment of low current conduction (5mA) in interfaces subjected to repetitive sliding displacement generating a well-known fretting wear phenomenon. Fretting wear solicitation appears as a process of very detrimental degradation. Besides surface deterioration, this process leads an increase of the electrical contact resistance and a possible loss of the electrical signal. This is particularly the case of the low level connectors which are very sensitive to electrical contact fluctuations. To remedy, connections actors develop new deposits to limit the use of noble ones such as gold. The objectives of this thesis are to establish a "table of use" coatings based on specific solicitations and define a methodology for the selection of deposits to optimize the lifetime connectors. The study covers different aspects such as the mechanical loading conditions influence, the thickness deposits influence, the type of deposit (noble, non-noble, doped), the displacement amplitude (microdisplacement and large displacement) and the electrical endurance formalization (energetic approach and power law)
Juřička, Viktor. "Vývoj polymerních správkových hmot s využitím druhotných surovin." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2018. http://www.nusl.cz/ntk/nusl-372189.
Jain, Shiwani. "Isotropically conductive adhesive filled with silver metalised polymer spheres." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/20297.
Cayssials, Franck. "Prise en compte des propriétés viscoélastiques de colles structurales pour l'optimisation de joints adhésifs vis-à-vis de leur résistance au choc." Paris, ENSAM, 1995. http://www.theses.fr/1995ENAM0043.
Liptak, Stephen C. "Modification, curing and flame retardation of epoxy resin networks." Diss., This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-11082006-133628/.
Graiff, Lorenzo. "Dispositivi protesici in Odontoiatria Digitale: dall'impronta digitale intraorale alla produzione con tecnologie Cad-Cam. Caratterizzazione in vitro della precisione di accoppiamento e delle proprietà meccaniche." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424453.
L’obiettivo di questo lavoro è studiare alcuni aspetti della moderna filiera produttiva digitale di manufatti protesici in campo dentale: dalla realizzazione dell’impronta ottica, direttamente nel cavo orale, alla finalizzazione del dispositivo protesico individualizzato per il paziente. La motivazione di questo studio risiede nell’esigenza sempre più sentita da parte di tutto il mondo dentale di ottimizzare e modernizzare i flussi di lavoro che sono ancora essenzialmente artigianali. Sfruttando le moderne tecnologie digitali, che si stanno rapidamente diffondendo in campo dentale, è possibile ottenere prodotti finiti di più alto standard qualitativo a fronte di costi di realizzazione più contenuti a condizione di diffondere ai clinici ed agli odontotecnici le conoscenze e le competenze necessarie all’utilizzo ottimale. In particolare sono stati presi in considerazione i seguenti temi di particolare rilevanza clinica: - la tecnologia di scansione ottica intraorale: sono state indagate le specificità operative e le prestazioni tecniche in particolare riferimento all’impiego per edentulie totali riabilitate mediante impianti, - i materiali ceramici innovativi, lavorabili mediante tecnologia Cad-Cam ed impiegati per realizzare protesi a ponte su denti naturali di tipo multilayer metalfree. E’ stato inoltre indagato un innovativo materiale in resina composita, anch’esso utilizzabile con tecnologia Cad-Cam ed impiegato per la realizzazione di corone singole su impianti. La revisione della letteratura tecnico scientifica, ha suggerito gli obbiettivi e gli aspetti metrologici del programma di ricerca sperimentale da condurre. Le indagini hanno riguardato aspetti di precisione ed accuratezza della lettura ottica della posizione degli impianti, di precisione geometrica di accoppiamento di protesi multilayer metal free, di resistenza meccanica di diversi tipologie di materiali e di adesione tra un recente composito a matrice resinosa, denominato Resin Nano-Ceramic (RNC) e zirconia; hanno previsto l’introduzione di strumenti e metodi consolidati in campo tecnico-scientifico, adatti a caratterizzare i processi di fabbricazione utilizzati, i materiali impiegati e i dispositivi realizzati. Più in dettaglio, l’attività ha riguardato: 1. lo studio, in termini di prestazioni metrologiche, del processo di acquisizione effettuato mediante il sistema di scansione True Definition Scanner su un campione clinico riproducente un'arcata completamente edentula riabilitata con 6 impianti; 2. la verifica della precisione geometrica di accoppiamento delle componenti, sotto e sovrastruttura, di protesi metalfree multilayer realizzate con materiali ceramici diversi (zirconia-disilicato di litio) prodotte mediante tecnologia Cad-Cam, e assemblate da due operatori diversi; l’assemblaggio/unione delle componenti, dei singoli ponti, viene invece realizzato manualmente dall’odontotecnico con tecnica totalmente artigianale; 3. l’analisi del comportamento meccanico, statico, delle protesi metalfree multilayer, citate al punto 2, confrontate con un altro tipo di protesi multilayer (provenienti dagli stessi progetti Cad) ma costituite da zirconia e ceramica feldspatica (RLT), 4. l’analisi mediante prova meccanica, statica e a fatica, della resistenza di un innovativo materiale in resina composita fornito in blocchetti per lavorazione Cad-Cam: Lava Ultimate. Questo nuovo materiale composito presenta, rispetto ad altri materiali estetici quanto a proprietà meccaniche dichiarate, (modulo di Young), un comportamento più simili al dente naturale. In quest’ottica, è stato utilizzato per realizzare corone singole su impianti, confrontando due modalità diverse di impiego: cementando una corona realizzata con questo composito e prodotta con tecnologia Cad-Cam direttamente su un pilastro standard in titanio fornito dall’industria, o realizzando con lavorazione Cad-Cam una sottostruttura in zirconia individualizzata e cementando su quest’ultima la corona in composito; 5. la verifica delle capacità adesive tra zirconia e Lava Ultimate, utilizzando due diversi cementi resinosi mediante test di taglio. Sulla base dei risultati delle campagne sperimentali condotte in questo studio è possibile affermare che: 1 le tecnologie di impronta ottica digitale intraorale sono in grado di rispondere ai requisiti clinici di precisione anche nel caso di arcate complete riabilitate su impianti, 2. le protesi multilayer metalfree, realizzate con tecnologia Cad-Cam secondo i requisiti di precisione propri dal workflow digitale, risentono dell’intervento di assemblaggio finale che esegue l’odontotecnico, con conseguente riduzione delle qualità di precisione stabilite in fase progettuale, 3. i ponti multilayer metalfreee presentano valori di resistenza alla frattura superiori o uguali ai valori minimi riportatati dalla letteratura scientifica 4. le corone su impianti realizzate con l’innovativo materiale composito, sottoposto a prove di resistenza statica e a fatica, quando cementate su un moncone individualizzato in zirconia, hanno caratteristiche meccaniche superiori alla soluzione più economica, che prevede la cementazione della corona direttamente ad un pilastro standardizzato in titanio. 5. l’utilizzo di cementi adesivi per cementare Lava Ultimate su zirconia, ha permesso di evidenziare comportamenti opposti per quanto riguarda le forze di adesione misurate con il test di taglio.
Belov, D. S., A. O. Volkhonsky, Blinkov I. V, E. A. Skryleva, and J. Michalski. "Multilayer Nanostructured Wear-Resistant Coatings with Increased Thermal Stability, Adapted to Varying Friction Conditions." Thesis, Sumy State University, 2013. http://essuir.sumdu.edu.ua/handle/123456789/35318.
Tong, Tianjian. "Co-effects of calcium carbonate and sodium bisulfite modification on improving water resistance of soy protein adhesives." Thesis, Kansas State University, 2012. http://hdl.handle.net/2097/14196.
Department of Grain Science & Industry
Xiuzhi Susan Sun
Bio-based protein adhesives derived from renewable resources, especially soy protein are becoming more significant due to the concerns about environment and health related issues and the limit of petroleum recourses. However, the relatively poor water resistance of soy-based protein adhesives limits its wide applications. The goal of this study was to improve the water resistance performance of soy-based protein adhesives by chemical modification. The specific objectives are 1) to modify soy protein with calcium carbonate (CaCO[subscript]3) and sodium bisulfite (NaHSO[subscript]3) as the denaturing agents; 2) to investigate the effects of calcium carbonate (CaCO[subscript]3) concentrations, curing time and curing temperatures on adhesion performance of the modified soy-based protein adhesives. In this study, the co-effects of NaHSO[subscript]3 and CaCO[subscript]3 on adhesion properties of soy protein adhesives were investigated. NaHSO[subscript]3 was added to soy flour slurry at constant concentration 6g/L, while concentration of CaCO[subscript]3 was chosen in the range of 0 to 23g/L. Soy protein adhesives modified with 4g/L and 16g/L CaCO[subscript]3 were selected to characterize the adhesion performance on 3 ply yellow pine plywood using the Response Surface Method (RSM). The effects of curing temperature and curing time on the adhesion properties were also studied. The major findings are 1) 4g/L CaCO[subscript]3, 6g/L NaHSO[subscript]3 modified soy protein adhesives (MSPA) had better adhesion performance (both dry and wet) than 16g/L CaCO[subscript]3, 6g/L NaHSO[subscript]3 MSPA; 2) Higher temperature (170°C) resulted in higher wet shear adhesion strengths; 3) Longer hot press time had positive impact on wet adhesion shear strength; and 4) 4g/L CaCO[subscript]3, 6g/L NaHSO[subscript]3 MSPA showed better adhesion shear strength after 2 weeks storage than 16g/L CaCO[subscript]3, 6g/L NaHSO[subscript]3 MSPA. In general, 4g/L CaCO[subscript]3, 6g/L NaHSO[subscript]3 MSPA, under longer hot press time and higher temperature would lead to a better adhesion performance.
Worschech, Claudia Cia. "Resistencia a fratura de pre-molares com preparos cavitarios extensos restaurados atraves de sistemas adesivos e não adesivos." [s.n.], 2000. http://repositorio.unicamp.br/jspui/handle/REPOSIP/289725.
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
Made available in DSpace on 2018-07-28T01:38:07Z (GMT). No. of bitstreams: 1 Worschech_ClaudiaCia_M.pdf: 487323 bytes, checksum: 63eea6a7fe297dfbe424400140e629bb (MD5) Previous issue date: 2000
Resumo: O propósito deste estudo foi avaliar a resistência à fratura de pré-molares superiores com extensos preparos cavitários e restaurados com sistemas adesivos e não adesivos. Trinta pré-molares superiores extraídos e livres de cáries ou fendas foram aleatoriamente divididos em 6 grupos com 5 dentes cada. Os dentes do grupo 1 não receberam preparos cavitários mésio-oclusais (controle positivo). No grupo 2, os dentes receberam preparos cavitários, mas não receberam restaurações (controle negativo). Os grupos 3, 4, 5 e 6 receberam os preparos cavitários e foram restaurados de acordo com os respectivos grupos experimentais: G3: Single Bond + Solitaire; G4: Single Bond + Z250; G5: Amálgama (Dispersalloy); G6: Amálgama (Dispersalloy) + Panavia. Todos os grupos foram submetidos ao teste de resistência à fratura numa Máquina de Ensaio Universal (Instron). O carregamento foi aplicado verticalmente através de uma esfera metálica de 4,7 mm de diâmetro, posicionada sobre as vertentes das cúspides dos pré-molares, numa velocidade de 0,5 mm/ min. As médias de carregamento necessárias para fraturar as amostras em cada grupo foram (em kgf), G6 = 168,46 (A) ; G5 = 155,19 (A) ; G1 = 153,54 (A) ; G4 = 148,86 (A); G3 = 80,08 (B) ; G2 = 20,51 (C). Os resultados do teste de TUKEY revelaram diferenças entre os grupos mostrados acima com letras diferentes. Assim, pôde-se concluir que os pré-molares restaurados através dos materiais citados foram capazes de resistir à fratura tanto quanto um dente íntegro, exceto aqueles restaurados com resina composta Solitaire
Abstract: The aim of this study was to evaluate the fracture resistance of maxillary premolars with large cavities preparations. Thirty extracted maxillary premolars, sound and free from cracks were randomly assigned to six groups of five teeth each. The teeth from group 1 did not receive cavity preparations (positive control). In group 2, the teeth received preparations but did not receive restorations (negative control). From groups 3 to 6, the teeth received MO preparations and were restored according to the following techniques: G3: single Bond + Solitaire; G4: Single Bond + Z250; G5: Amalgam; G6: Amalgam + Panavia. All groups were submitted to fracture resistance test in a Universal Test Machine (Instron). The load was applied vertically through a metallic sphere of 4,7 mm diameter, touching only the cusps and never the restorations or cavity margins. The average load necessary to fracture the samples in each group was (in Kgf), G6= 168,46 (A); G5 = 155,19 (A) ; G1=153,54 (A) ; G4= 148,86 (A); G3= 80,08 (B) ; G2= 20,51 (C). The data were submitted to Tukey¿s test that revealed differences among some groups showed above with different letters. These results show that all materials tested can recover the fracture resistance of maxillary premolars as much as a sound tooth, except Solitaire resin
Mestrado
Dentística
Mestre em Clínica Odontológica
Sauveur, Juliette. "Development and characterization of models of resistance to T-DM1." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1266/document.
T-DM1 is an antibody-drug conjugate composed of the monoclonal antibody trastuzumab linked to DM1, a potent tubulin binding agent. Despite its efficacy in the treatment of HER2-positive breast cancer patients, acquired resistance to T-DM1 was observed during clinical trials. In order to study resistance mechanisms to T-DM1, we developed resistance models using OE-19 (esophageal) and MDA-MB-361 (breast) cancer cell lines in the absence or presence of ciclosporin A (CsA), an inhibitor of MDR1 mediated efflux. Resistant cells selected with T-DM1 alone are named “TR” and cells selected in the presence of T-DM1 and CsA are called “TCR”. OE-19 TCR cells showed modifications in adhesion gene expression, migration and adhesion strength, combined with an increased sensitivity to a RHOA inhibitor. Also, OE-19 TR cells presented an overexpression of COX-2 associated with an increased amount of PGE2 in the supernatant. A deregulation of the genes involved in the prostaglandin pathways was found in OE-19 TR and TCR cells, associated with increased sensitivity to aspirin. In conclusion, we found two signaling pathways deregulated in cell lines resistant to T-DM1. These results need to be validated using samples from patients resistant to T-DM1. Targeting the adhesion or the prostaglandin pathway could be of benefit for patients with T-DM1 resistant cancers
Jeong, Seung Hee. "Soft Intelligence : Liquids Matter in Compliant Microsystems." Doctoral thesis, Uppsala universitet, Mikrosystemteknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281281.
David, Guy. "Traitements de surface et agents de couplage dentinaire : etude de la resistance mecanique du joint adhesif-dentine in vitro et in vivo." Paris 7, 1990. http://www.theses.fr/1990PA07GS01.
Augustin, Till [Verfasser], and Bodo [Akademischer Betreuer] Fiedler. "Structural health monitoring of carbon fiber reinforced polymers and carbon nanotube modified adhesive joints via electrical resistance measurement / Till Augustin ; Betreuer: Bodo Fiedler." Hamburg : Universitätsbibliothek der Technischen Universität Hamburg-Harburg, 2018. http://d-nb.info/1166754693/34.
Al-Mansouri, Omar. "Behavior of bonded anchors in concrete under fire." Thesis, Ecole nationale supérieure Mines-Télécom Lille Douai, 2020. http://www.theses.fr/2020MTLD0011.
The technique of bonded anchors consists of fastening a threaded rod in a drilled hole in hardened concrete by polymer adhesives. The main advantages of this technique are ease of installation and the high mechanical properties of the adhesive at ambient temperature. Due to the adherence of the adhesive resin, this type of anchors can be designed to ensure similar or even higher performances compared to other anchor systems (mechanical and cast-in). However, at high temperatures, e.g. fire situation, the adherence of the adhesive degrades rapidly. Fire decreases the adherence of the adhesive and leads to the inability of the anchor to support the fixed objects. This creates a risk on the lives and goods inside the building. Several accidents occurred like the collapse of the Big Dig Tunnel in the USA (2006) and the Sasago tunnel in Japan (2012) and highlighted the importance of having reliable evalutation methods of this type of anchors. The objective of this thesis is to establish an assessment and a design method to ensure the structural resistance of bonded anchors in fire situations. This project is structured into four main parts:i. Experimental protocols for fire tests on bonded anchors. Pull-out fire tests were conducted on bonded anchors (epoxy adhesive). Temperature profiles along the embedment depth of anchors were determined experimentally for different test configurations. Then, these temperature profiles were used as entry data to calculate the fire resistance of anchors using Pinoteau’s method (Resistance Integration Method). This study allowed to precise the experimental conditions to be adopted for fire evaluation of bonded anchors. ii. Proposition of a design model based on transient thermal calculations using finite element method in 3D. Temperature profiles were calculated using the thermophysical material properties of concrete and steel in the Eurocode. 3D modelling was compared to 2D modelling commonly used in the literature. Both approaches were compared to measurements during fire tests and coupled with Pinoteau’s method to assess their impact on the calculation of fire resistance of anchors. Following the validation of the 3D model, thermal investigations were conducted on other parameters that could influence fire tests of bonded anchors. This study allowed to validate the 3D modelling approach as the most representative of the problem of bonded anchors exposed to fire.iii. Validation of Pinoteau’s method for the design of bonded anchors under fire by using the previously proposed design model. Calculations of fire resistance of three different bonded anchor products were compared to pull-out tests. This study conducted on a wide range of anchor sizes lead to the validation of the Pinoteau’s Method for the design of bonded anchors.iv. Study of the behavior of bonded anchors in cracked concrete at high temperatures. An assessment method was developed to determine the reduction of bond strength due to cracked concrete, at high temperatures (electrical heating). Tests were conducted on bonded anchors (epoxy adhesive) in cracked and uncracked concrete, at ambient and high temperatures. The evolution of the reduction with temperature increase was investigated. This study ensured a good repeatability of test results due to the increased testing potential and the good control of the applied heating scenario
Hodul, Jakub. "Vývoj speciálních sanačních hmot na beton pro extrémní namáhání s využitím druhotných surovin." Doctoral thesis, Vysoké učení technické v Brně. Fakulta stavební, 2019. http://www.nusl.cz/ntk/nusl-401596.